SIMILAR PATTERNS OF AMINO ACIDS FOR 1TT6_A_DESA129_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP3)

(Cricket
paralysis virus) 		no annotation 4 LYS C 198
LEU C 205
LEU C 196
SER C 193
 None
 0.97A 1tt6A-1b35C:
0.6		 1tt6A-1b35C:
14.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
LEU A 110
SER A 117
 None
 0.48A 1tt6A-1gkeA:
21.0		 1tt6A-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		4 LYS A 409
LEU A 413
LEU A 398
SER A 397
 None
 1.49A 1tt6A-1hcuA:
0.0		 1tt6A-1hcuA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 LYS A 190
LEU A 308
LEU A 305
SER A 302
 None
 1.47A 1tt6A-1kwmA:
0.0		 1tt6A-1kwmA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		4 LYS A 241
LEU A 237
LEU A 213
SER A 212
 None
 1.24A 1tt6A-1p9pA:
undetectable		 1tt6A-1p9pA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sed HYPOTHETICAL PROTEIN
YHAI

(Bacillus
subtilis) 		PF08963
(DUF1878) 		4 LYS A  70
LEU A  74
LEU A  53
SER A  54
 MPD  A 714 ( 2.5A)
MPD  A 712 ( 4.9A)
None
None
 1.30A 1tt6A-1sedA:
undetectable		 1tt6A-1sedA:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
LEU A 110
SER A 117
 None
 0.94A 1tt6A-1tfpA:
19.1		 1tt6A-1tfpA:
73.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 LYS C 801
LEU C 752
LEU C 747
SER C 744
 None
 1.33A 1tt6A-1u6gC:
0.0		 1tt6A-1u6gC:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LYS A 400
LEU A 374
LEU A 321
SER A 446
 None
 1.47A 1tt6A-1w99A:
0.0		 1tt6A-1w99A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfr PHEROMONE-BINDING
PROTEIN

(Bombyx mori) 		PF01395
(PBP_GOBP) 		4 LYS A  20
LEU A  16
LEU A  55
SER A  56
 None
 1.46A 1tt6A-1xfrA:
undetectable		 1tt6A-1xfrA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		4 LYS A 190
LEU A 308
LEU A 305
SER A 302
 None
 1.37A 1tt6A-1zliA:
0.0		 1tt6A-1zliA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgh VINORINE SYNTHASE

(Rauvolfia
serpentina) 		PF02458
(Transferase) 		4 LYS A 225
LEU A 229
LEU A 247
SER A 243
 None
 1.30A 1tt6A-2bghA:
undetectable		 1tt6A-2bghA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0i DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LYS A  66
LEU A 308
LEU A 304
SER A  69
 None
 1.28A 1tt6A-2d0iA:
undetectable		 1tt6A-2d0iA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1

(Homo sapiens) 		no annotation 4 LYS A  81
LEU A  89
LEU A  70
SER A  69
 None
 1.08A 1tt6A-2d58A:
undetectable		 1tt6A-2d58A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 LYS A 332
LEU A 293
LEU A 297
SER A 302
 None
 1.38A 1tt6A-2iu3A:
undetectable		 1tt6A-2iu3A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LYS A 434
LEU A 431
LEU A 310
SER A 311
 None
 1.38A 1tt6A-2ivfA:
undetectable		 1tt6A-2ivfA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jre C60-1 PDZ DOMAIN
PEPTIDE

(-) 		PF00595
(PDZ) 		4 LYS A  68
LEU A  70
LEU A  99
SER A  15
 None
 0.88A 1tt6A-2jreA:
undetectable		 1tt6A-2jreA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol5 PAI 2 PROTEIN

(Geobacillus
stearothermophilus) 		PF04299
(FMN_bind_2) 		4 LYS A 199
LEU A 196
LEU A 166
SER A 167
 None
 1.41A 1tt6A-2ol5A:
undetectable		 1tt6A-2ol5A:
15.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
LEU A 110
SER A 117
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
 0.63A 1tt6A-3fc8A:
23.3		 1tt6A-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im9 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Staphylococcus
aureus) 		PF00698
(Acyl_transf_1) 		4 LYS A 152
LEU A 173
LEU A 147
SER A 146
 None
 1.13A 1tt6A-3im9A:
undetectable		 1tt6A-3im9A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvg T-CELL SURFACE
GLYCOPROTEIN CD1A1
ANTIGEN

(Gallus gallus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 LYS A  10
LEU A  12
LEU A  28
SER A  38
 None
 1.38A 1tt6A-3jvgA:
undetectable		 1tt6A-3jvgA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363

(Listeria
monocytogenes) 		PF03575
(Peptidase_S51) 		4 LYS A  27
LEU A  24
LEU A  55
SER A  54
 None
 1.46A 1tt6A-3l4eA:
undetectable		 1tt6A-3l4eA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		4 LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.41A 1tt6A-3m7dA:
undetectable		 1tt6A-3m7dA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 LYS A 211
LEU A 207
LEU A 246
SER A 244
 None
 1.36A 1tt6A-3ojyA:
undetectable		 1tt6A-3ojyA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozx RNASE L INHIBITOR

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		4 LYS A 192
LEU A 258
LEU A 227
SER A 226
 None
 1.30A 1tt6A-3ozxA:
undetectable		 1tt6A-3ozxA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sf5 UREASE ACCESSORY
PROTEIN UREF

(Helicobacter
pylori) 		PF01730
(UreF) 		4 LYS A 221
LEU A 225
LEU A  87
SER A  88
 None
 1.33A 1tt6A-3sf5A:
undetectable		 1tt6A-3sf5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxj NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE

(Vibrio cholerae) 		PF14489
(QueF)
PF14819
(QueF_N) 		4 LYS A  96
LEU A 100
LEU A  35
SER A  34
 NAP  A 291 (-3.1A)
None
None
None
 1.07A 1tt6A-3uxjA:
undetectable		 1tt6A-3uxjA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 LYS M   1
LEU M   4
LEU M   8
SER M  32
 None
 1.45A 1tt6A-4heaM:
undetectable		 1tt6A-4heaM:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inw PHEROMONE-BINDING
PROTEIN 1

(Amyelois
transitella) 		PF01395
(PBP_GOBP) 		4 LYS A  20
LEU A  16
LEU A  55
SER A  56
 None
None
None
1EY  A 201 (-3.5A)
 1.25A 1tt6A-4inwA:
undetectable		 1tt6A-4inwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnp LIPOPROTEIN

(Staphylococcus
aureus) 		PF01297
(ZnuA) 		4 LYS A 298
LEU A 184
LEU A 145
SER A 144
 None
 1.35A 1tt6A-4nnpA:
undetectable		 1tt6A-4nnpA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv1 FORMYLTRANSFERASE

(Francisella
tularensis) 		no annotation 4 LYS C  65
LEU C  62
LEU C  82
SER C  85
 None
 1.47A 1tt6A-4nv1C:
undetectable		 1tt6A-4nv1C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh0 BETA-LACTAMASE
OXA-58

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		4 LYS A 273
LEU A  47
LEU A 266
SER A 267
 None
 1.47A 1tt6A-4oh0A:
undetectable		 1tt6A-4oh0A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 LYS A 294
LEU A 290
LEU A 289
SER A 169
 None
 1.49A 1tt6A-4onoA:
undetectable		 1tt6A-4onoA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqr 3,5-EPIMERASE/4-REDU
CTASE

(Arabidopsis
thaliana) 		PF04321
(RmlD_sub_bind) 		4 LYS A  30
LEU A  27
LEU A 204
SER A 207
 None
 1.32A 1tt6A-4qqrA:
undetectable		 1tt6A-4qqrA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkx LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		4 LYS L 294
LEU L 245
LEU L 308
SER L 334
 None
 1.34A 1tt6A-4tkxL:
undetectable		 1tt6A-4tkxL:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		4 LYS A 108
LEU A 105
LEU A 134
SER A  22
 None
 1.47A 1tt6A-4yisA:
undetectable		 1tt6A-4yisA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 LYS A1236
LEU A1001
LEU A1241
SER A1250
 None
 1.48A 1tt6A-5amqA:
undetectable		 1tt6A-5amqA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		4 LYS A 322
LEU A 328
LEU A 329
SER A 333
 None
 1.49A 1tt6A-5aqaA:
undetectable		 1tt6A-5aqaA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.42A 1tt6A-5hm5A:
undetectable		 1tt6A-5hm5A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		4 LYS A  26
LEU A  31
LEU A  33
SER A  34
 None
 1.30A 1tt6A-5m10A:
undetectable		 1tt6A-5m10A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4c PROLYL
OLIGOPEPTIDASE

(Galerina
marginata) 		no annotation 4 LYS A 702
LEU A 696
LEU A 164
SER A 142
 None
 1.46A 1tt6A-5n4cA:
undetectable		 1tt6A-5n4cA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LYS A1775
LEU A1778
LEU A1825
SER A1824
 None
 1.37A 1tt6A-5nugA:
undetectable		 1tt6A-5nugA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00849
(PseudoU_synth_2) 		4 LYS A 167
LEU A 169
LEU A 145
SER A 115
 None
 1.12A 1tt6A-5vbbA:
undetectable		 1tt6A-5vbbA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica) 		no annotation 4 LYS M 114
LEU M 110
LEU M 136
SER M 135
 BR  M 501 (-3.6A)
None
None
None
 1.13A 1tt6A-5wc8M:
undetectable		 1tt6A-5wc8M:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF05214
(Baculo_p33) 		4 LYS A  88
LEU A  92
LEU A  94
SER A  96
 None
 1.10A 1tt6A-5xtoA:
undetectable		 1tt6A-5xtoA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anr COLIBACTIN
SELF-PROTECTION
PROTEIN CLBS

(Escherichia
coli) 		no annotation 4 LYS A 166
LEU A 164
LEU A 161
SER A 158
 None
 1.42A 1tt6A-6anrA:
undetectable		 1tt6A-6anrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Homo sapiens) 		no annotation 4 LYS A  75
LEU A  77
LEU A 126
SER A 118
 None
 1.42A 1tt6A-6c8aA:
undetectable		 1tt6A-6c8aA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 4 LYS A 213
LEU A 215
LEU A 258
SER A 253
 CJT  A 502 (-3.0A)
None
None
None
 1.14A 1tt6A-6f3dA:
undetectable		 1tt6A-6f3dA:
16.54