SIMILAR PATTERNS OF AMINO ACIDS FOR 1TSN_A_C2FA266_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1att | ANTITHROMBIN III (Bos taurus) |
PF00079(Serpin) | 5 | ILE A 391LEU A 171GLY A 94VAL A 356ALA A 357 | None | 1.13A | 1tsnA-1attA:0.0 | 1tsnA-1attA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cbf | COBALT-PRECORRIN-4TRANSMETHYLASE (Bacillusmegaterium) |
PF00590(TP_methylase) | 5 | ILE A 243LEU A 155LEU A 249GLY A 246ALA A 137 | None | 1.15A | 1tsnA-1cbfA:0.0 | 1tsnA-1cbfA:19.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ci7 | PROTEIN (THYMIDYLATESYNTHASE) (Pneumocystiscarinii) |
PF00303(Thymidylat_synt) | 7 | ILE A 86TRP A 87LEU A 170LEU A 205GLY A 206PHE A 209TYR A 242 | CB3 A 768 (-3.6A)NoneUMP A 767 (-4.7A)CB3 A 768 ( 4.4A)UMP A 767 (-3.7A)CB3 A 768 (-3.6A)CB3 A 768 ( 4.7A) | 0.94A | 1tsnA-1ci7A:37.5 | 1tsnA-1ci7A:45.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fnz | BARK AGGLUTININ I,POLYPEPTIDE A (Robiniapseudoacacia) |
PF00139(Lectin_legB) | 5 | ILE A 121LEU A 51LEU A 101GLY A 108PHE A 110 | None | 1.16A | 1tsnA-1fnzA:0.0 | 1tsnA-1fnzA:21.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvy | THYMIDYLATE SYNTHASE (Homo sapiens) |
PF00303(Thymidylat_synt) | 8 | ILE A 108TRP A 109LEU A 192LEU A 221GLY A 222PHE A 225TYR A 258ALA A 312 | D16 A 414 (-3.7A)D16 A 414 (-3.7A)NoneD16 A 414 (-4.0A)D16 A 414 (-3.3A)D16 A 414 (-3.6A)UMP A 314 ( 4.4A)D16 A 414 (-3.6A) | 0.86A | 1tsnA-1hvyA:39.3 | 1tsnA-1hvyA:51.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hxj | BETA-GLUCOSIDASE (Zea mays) |
PF00232(Glyco_hydro_1) | 5 | SER A 30ILE A 34LEU A 81GLY A 469VAL A 473 | None | 1.10A | 1tsnA-1hxjA:0.0 | 1tsnA-1hxjA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iw8 | ACID PHOSPHATASE (Shimwelliablattae) |
PF01569(PAP2) | 6 | HIS A 189SER A 148LEU A 179GLY A 176VAL A 75ALA A 76 | SO4 A1001 (-4.5A)SO4 A1001 (-3.6A)NoneNoneNoneNone | 1.38A | 1tsnA-1iw8A:undetectable | 1tsnA-1iw8A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lqk | PROBABLE FOSFOMYCINRESISTANCE PROTEIN (Pseudomonasaeruginosa) |
PF00903(Glyoxalase) | 5 | ILE A 19LEU A 47GLY A 37VAL A 12ALA A 11 | None | 1.15A | 1tsnA-1lqkA:0.0 | 1tsnA-1lqkA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qvz | YDR533C PROTEIN (Saccharomycescerevisiae) |
PF01965(DJ-1_PfpI) | 5 | LEU A 8GLY A 107PHE A 27VAL A 137ALA A 136 | NoneCSO A 138 ( 3.5A)NoneCSO A 138 ( 2.6A)None | 1.02A | 1tsnA-1qvzA:0.0 | 1tsnA-1qvzA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ry2 | ACETYL-COENZYME ASYNTHETASE 1 (Saccharomycescerevisiae) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 5 | ILE A 662LEU A 668LEU A 624VAL A 601ALA A 602 | None | 1.14A | 1tsnA-1ry2A:0.0 | 1tsnA-1ry2A:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sh2 | RNA POLYMERASE (Norwalk virus) |
PF00680(RdRP_1) | 5 | LEU A 367LEU A 298GLY A 297PHE A 70ALA A 312 | None | 1.16A | 1tsnA-1sh2A:undetectable | 1tsnA-1sh2A:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x25 | HYPOTHETICAL UPF0076PROTEIN ST0811 (Sulfurisphaeratokodaii) |
PF01042(Ribonuc_L-PSP) | 5 | ILE A 60LEU A 54GLY A 30VAL A 120ALA A 74 | None | 1.08A | 1tsnA-1x25A:undetectable | 1tsnA-1x25A:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xmb | IAA-AMINO ACIDHYDROLASE HOMOLOG 2 (Arabidopsisthaliana) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | HIS A 380SER A 382ILE A 196LEU A 109ALA A 150 | None | 1.13A | 1tsnA-1xmbA:undetectable | 1tsnA-1xmbA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a5v | CARBONIC ANHYDRASE(CARBONATEDEHYDRATASE)(CARBONICDEHYDRATASE) (Mycobacteriumtuberculosis) |
PF00484(Pro_CA) | 5 | ILE A 61GLY A 16PHE A 62VAL A 21ALA A 22 | None | 1.16A | 1tsnA-2a5vA:undetectable | 1tsnA-2a5vA:19.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2aaz | THYMIDYLATE SYNTHASE (Cryptococcusneoformans) |
PF00303(Thymidylat_synt) | 7 | ILE A 100TRP A 101LEU A 184LEU A 222GLY A 223PHE A 226TYR A 259 | CB3 A2351 (-3.6A)CB3 A2351 (-3.7A)NoneCB3 A2351 (-4.1A)CB3 A2351 ( 3.2A)CB3 A2351 (-3.8A)CB3 A2351 ( 4.3A) | 0.27A | 1tsnA-2aazA:undetectable | 1tsnA-2aazA:43.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ajr | SUGAR KINASE, PFKBFAMILY (Thermotogamaritima) |
PF00294(PfkB) | 5 | SER A 50ILE A 47LEU A 257GLY A 42ALA A 10 | NoneNoneNoneNoneACT A 321 ( 4.4A) | 1.09A | 1tsnA-2ajrA:undetectable | 1tsnA-2ajrA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bkw | ALANINE-GLYOXYLATEAMINOTRANSFERASE 1 (Saccharomycescerevisiae) |
PF00266(Aminotran_5) | 6 | HIS A 145SER A 179ILE A 180LEU A 267LEU A 196GLY A 68 | NoneNoneNoneNoneNonePLP A1201 (-3.6A) | 1.47A | 1tsnA-2bkwA:undetectable | 1tsnA-2bkwA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cn3 | BETA-1,4-XYLOGLUCANHYDROLASE (Ruminiclostridiumthermocellum) |
PF02012(BNR) | 5 | LEU A 474LEU A 463GLY A 506VAL A 462ALA A 747 | None | 1.13A | 1tsnA-2cn3A:undetectable | 1tsnA-2cn3A:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fno | AGR_PAT_752P (Agrobacteriumfabrum) |
no annotation | 5 | ILE A 167LEU A 157GLY A 82VAL A 102ALA A 99 | None | 1.08A | 1tsnA-2fnoA:undetectable | 1tsnA-2fnoA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h1c | TRAFFICKING PROTEINB (Neisseriagonorrhoeae) |
PF01850(PIN) | 5 | SER A 10ILE A 9LEU A 30LEU A 68ALA A 72 | None | 1.13A | 1tsnA-2h1cA:undetectable | 1tsnA-2h1cA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ILE A 316LEU A 429GLY A 430PHE A 433TYR A 466 | NoneNone DU A 611 (-3.5A)None DU A 611 (-4.6A) | 0.93A | 1tsnA-2h2qA:34.5 | 1tsnA-2h2qA:26.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 6 | ILE A 316TRP A 317LEU A 400GLY A 430PHE A 433TYR A 466 | NoneNoneNone DU A 611 (-3.5A)None DU A 611 (-4.6A) | 1.00A | 1tsnA-2h2qA:34.5 | 1tsnA-2h2qA:26.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hms | YUAA PROTEIN (Bacillussubtilis) |
PF02254(TrkA_N) | 6 | ILE A 37LEU A 66LEU A 14GLY A 13VAL A 42ALA A 52 | NAI A 601 (-3.8A)NoneNoneNAI A 601 (-3.3A)NoneNone | 1.35A | 1tsnA-2hmsA:undetectable | 1tsnA-2hmsA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mjh | FEMALEGERMLINE-SPECIFICTUMOR SUPPRESSORGLD-1 (Caenorhabditiselegans) |
PF00013(KH_1) | 5 | HIS A 261SER A 251LEU A 302LEU A 226GLY A 223 | NoneNoneNone A B 22 ( 3.6A) U B 20 ( 3.1A) | 1.10A | 1tsnA-2mjhA:undetectable | 1tsnA-2mjhA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nvu | MALTOSE BINDINGPROTEIN/NEDD8-ACTIVATING ENZYME E1CATALYTIC SUBUNITCHIMERA (Homo sapiens) |
PF00899(ThiF)PF08825(E2_bind)PF13416(SBP_bac_8) | 5 | ILE B2192LEU B2145LEU B2158GLY B2156TYR B2135 | NoneATP B 103 ( 4.9A)NoneNoneNone | 1.15A | 1tsnA-2nvuB:undetectable | 1tsnA-2nvuB:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oip | CHAIN A, CRYSTALSTRUCTURE OF DHFR (Cryptosporidiumhominis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 8 | ILE A 315TRP A 316LEU A 399LEU A 429GLY A 430PHE A 433TYR A 466ALA A 520 | CB3 A 604 ( 3.7A)CB3 A 604 ( 4.4A)NoneCB3 A 604 ( 4.4A)CB3 A 604 ( 3.4A)CB3 A 604 ( 3.9A)UMP A 603 ( 4.3A)CB3 A 604 ( 4.0A) | 0.42A | 1tsnA-2oipA:39.2 | 1tsnA-2oipA:26.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyv | XAA-HIS DIPEPTIDASE (Histophilussomni) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | TRP A 13LEU A 12LEU A 112GLY A 113VAL A 105 | None | 1.05A | 1tsnA-2qyvA:undetectable | 1tsnA-2qyvA:19.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2tdd | THYMIDYLATE SYNTHASE (Lactobacilluscasei) |
PF00303(Thymidylat_synt) | 5 | ILE A 81LEU A 195GLY A 225PHE A 228TYR A 261 | THF A 568 ( 4.8A)THF A 568 (-4.6A)UFP A 529 ( 4.0A)THF A 568 (-4.8A)UFP A 529 (-4.7A) | 0.82A | 1tsnA-2tddA:35.5 | 1tsnA-2tddA:51.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2tdd | THYMIDYLATE SYNTHASE (Lactobacilluscasei) |
PF00303(Thymidylat_synt) | 5 | ILE A 81TRP A 82LEU A 195GLY A 225PHE A 228 | THF A 568 ( 4.8A)THF A 568 ( 4.6A)THF A 568 (-4.6A)UFP A 529 ( 4.0A)THF A 568 (-4.8A) | 0.94A | 1tsnA-2tddA:35.5 | 1tsnA-2tddA:51.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2tdd | THYMIDYLATE SYNTHASE (Lactobacilluscasei) |
PF00303(Thymidylat_synt) | 5 | LEU A 195LEU A 224GLY A 225PHE A 228TYR A 261 | THF A 568 (-4.6A)THF A 568 (-3.6A)UFP A 529 ( 4.0A)THF A 568 (-4.8A)UFP A 529 (-4.7A) | 0.75A | 1tsnA-2tddA:35.5 | 1tsnA-2tddA:51.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w48 | SORBITOL OPERONREGULATOR (Klebsiellapneumoniae) |
PF04198(Sugar-bind)PF13936(HTH_38) | 5 | SER A 123LEU A 106GLY A 280VAL A 79ALA A 78 | None | 1.06A | 1tsnA-2w48A:undetectable | 1tsnA-2w48A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x50 | TRYPANOTHIONEREDUCTASE (Leishmaniainfantum) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | SER A 178ILE A 199LEU A 227PHE A 203ALA A 365 | FAD A1487 ( 4.0A)NDP A1488 (-3.9A)NoneNoneNone | 1.01A | 1tsnA-2x50A:undetectable | 1tsnA-2x50A:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c6g | CYTOCHROME P450 2R1 (Homo sapiens) |
PF00067(p450) | 6 | SER A 188ILE A 211LEU A 257GLY A 305VAL A 253ALA A 250 | NoneNoneNoneVD3 A 701 ( 3.9A)VD3 A 701 ( 4.2A)VD3 A 701 (-3.3A) | 1.39A | 1tsnA-3c6gA:undetectable | 1tsnA-3c6gA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d31 | SULFATE/MOLYBDATEABC TRANSPORTER,PERMEASE PROTEIN (Methanosarcinaacetivorans) |
PF00528(BPD_transp_1) | 5 | ILE C 41GLY C 47PHE C 45VAL C 246ALA C 245 | None | 1.09A | 1tsnA-3d31C:undetectable | 1tsnA-3d31C:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eat | PYOVERDINEBIOSYNTHESIS PROTEINPVCB (Pseudomonasaeruginosa) |
PF02668(TauD) | 5 | HIS X 239SER X 142LEU X 15GLY X 26PHE X 25 | None | 1.13A | 1tsnA-3eatX:undetectable | 1tsnA-3eatX:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3goc | ENDONUCLEASE V (Streptomycesavermitilis) |
PF04493(Endonuclease_5) | 5 | HIS A 195GLY A 171TYR A 116VAL A 141ALA A 142 | None | 1.10A | 1tsnA-3gocA:undetectable | 1tsnA-3gocA:19.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ix6 | THYMIDYLATE SYNTHASE (Brucellamelitensis) |
PF00303(Thymidylat_synt) | 5 | HIS A 51LEU A 172GLY A 173PHE A 176TYR A 209 | None | 0.80A | 1tsnA-3ix6A:35.3 | 1tsnA-3ix6A:48.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ix6 | THYMIDYLATE SYNTHASE (Brucellamelitensis) |
PF00303(Thymidylat_synt) | 5 | LEU A 143LEU A 172GLY A 173PHE A 176TYR A 209 | None | 0.86A | 1tsnA-3ix6A:35.3 | 1tsnA-3ix6A:48.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 8 | SER A 281ILE A 306TRP A 307LEU A 390LEU A 419GLY A 420PHE A 423TYR A 456 | NoneGOL A 516 (-3.9A)GOL A 516 (-3.7A)NoneNoneNoneNoneNone | 0.68A | 1tsnA-3kjrA:38.6 | 1tsnA-3kjrA:26.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mru | AMINOACYL-HISTIDINEDIPEPTIDASE (Vibrioalginolyticus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | TRP A 17LEU A 16LEU A 116GLY A 117VAL A 109 | None | 1.16A | 1tsnA-3mruA:undetectable | 1tsnA-3mruA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o0h | GLUTATHIONEREDUCTASE (Bartonellahenselae) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | SER A 160ILE A 181LEU A 206PHE A 185ALA A 343 | FAD A 500 (-3.8A)FAD A 500 ( 4.3A)NoneNoneNone | 1.08A | 1tsnA-3o0hA:undetectable | 1tsnA-3o0hA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3od1 | ATPPHOSPHORIBOSYLTRANSFERASE REGULATORYSUBUNIT (Bacillushalodurans) |
PF13393(tRNA-synt_His) | 5 | LEU A 249GLY A 294PHE A 313VAL A 160ALA A 161 | None | 1.02A | 1tsnA-3od1A:undetectable | 1tsnA-3od1A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3odp | PUTATIVETAGATOSE-6-PHOSPHATEKETOSE/ALDOSEISOMERASE (Clostridiumnovyi) |
PF01380(SIS) | 5 | SER A 186ILE A 142LEU A 111GLY A 72ALA A 65 | NoneNoneNoneNonePO4 A 402 ( 4.6A) | 1.12A | 1tsnA-3odpA:undetectable | 1tsnA-3odpA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t43 | HIV EPITOPE-SCAFFOLD4E10_1XIZA_S0_006_C (syntheticconstruct) |
PF00359(PTS_EIIA_2) | 5 | SER A 130LEU A 91GLY A 65VAL A 47ALA A 48 | None | 1.13A | 1tsnA-3t43A:undetectable | 1tsnA-3t43A:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ti7 | BASIC EXTRACELLULARSUBTILISIN-LIKEPROTEASE BPRV (Dichelobacternodosus) |
PF00082(Peptidase_S8) | 5 | ILE A 258LEU A 255TYR A 14VAL A 123ALA A 124 | NoneNoneNone CA A 353 (-4.8A)None | 1.13A | 1tsnA-3ti7A:undetectable | 1tsnA-3ti7A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uxy | SHORT-CHAINDEHYDROGENASE/REDUCTASE SDR (Rhodobactersphaeroides) |
PF13561(adh_short_C2) | 5 | ILE A 75LEU A 70GLY A 30PHE A 4ALA A 45 | None | 1.13A | 1tsnA-3uxyA:undetectable | 1tsnA-3uxyA:24.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3v8h | THYMIDYLATE SYNTHASE (Burkholderiathailandensis) |
PF00303(Thymidylat_synt) | 5 | SER A 54LEU A 189LEU A 220GLY A 221TYR A 257 | NoneCIT A 400 (-4.3A)NoneNoneCIT A 400 (-4.5A) | 0.73A | 1tsnA-3v8hA:34.3 | 1tsnA-3v8hA:36.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3v8h | THYMIDYLATE SYNTHASE (Burkholderiathailandensis) |
PF00303(Thymidylat_synt) | 6 | SER A 54TRP A 80LEU A 189GLY A 221PHE A 224TYR A 257 | NoneNoneCIT A 400 (-4.3A)NoneNoneCIT A 400 (-4.5A) | 0.96A | 1tsnA-3v8hA:34.3 | 1tsnA-3v8hA:36.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v96 | STROMELYSIN-2 (Homo sapiens) |
PF00413(Peptidase_M10) | 5 | HIS B 195ILE B 160LEU B 211VAL B 129ALA B 128 | ZN B 302 (-3.2A)NoneNoneNoneNone | 1.15A | 1tsnA-3v96B:undetectable | 1tsnA-3v96B:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wd7 | TYPE III POLYKETIDESYNTHASES ACRIDONESYNTHASE (Citrus xmicrocarpa) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | SER A 327ILE A 301GLY A 167VAL A 382ALA A 242 | SER A 327 ( 0.0A)ILE A 301 ( 0.4A)GLY A 167 ( 0.0A)VAL A 382 ( 0.6A)ALA A 242 ( 0.0A) | 1.13A | 1tsnA-3wd7A:undetectable | 1tsnA-3wd7A:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a25 | FERRITIN DPS FAMILYPROTEIN (Kineococcusradiotolerans) |
PF00210(Ferritin) | 5 | HIS A 132ILE A 128LEU A 30VAL A 77ALA A 78 | None | 1.16A | 1tsnA-4a25A:undetectable | 1tsnA-4a25A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b0s | DEAMIDASE-DEPUPYLASEDOP (Acidothermuscellulolyticus) |
PF03136(Pup_ligase) | 5 | ILE A 174LEU A 301LEU A 286GLY A 284ALA A 309 | None | 1.06A | 1tsnA-4b0sA:undetectable | 1tsnA-4b0sA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bgb | PUTATIVE SUGARKINASE MK0840 (Methanopyruskandleri) |
PF03702(AnmK) | 5 | ILE A 43LEU A 106GLY A 121VAL A 135ALA A 345 | None | 1.00A | 1tsnA-4bgbA:undetectable | 1tsnA-4bgbA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dna | PROBABLE GLUTATHIONEREDUCTASE (Sinorhizobiummeliloti) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | SER A 160ILE A 181LEU A 206PHE A 185ALA A 344 | FAD A 500 ( 4.2A)FAD A 500 ( 4.4A)NoneNoneNone | 1.08A | 1tsnA-4dnaA:undetectable | 1tsnA-4dnaA:20.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dq1 | THYMIDYLATE SYNTHASE (Staphylococcusaureus) |
PF00303(Thymidylat_synt) | 5 | ILE A 84LEU A 198GLY A 228PHE A 231TYR A 264 | NoneNoneUMP A 501 ( 4.0A)NoneUMP A 501 (-4.2A) | 1.11A | 1tsnA-4dq1A:36.1 | 1tsnA-4dq1A:50.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dqv | PROBABLE PEPTIDESYNTHETASE NRP(PEPTIDE SYNTHASE) (Mycobacteriumtuberculosis) |
PF07993(NAD_binding_4) | 5 | SER A 215ILE A 211TYR A 335VAL A 252ALA A 251 | None | 1.10A | 1tsnA-4dqvA:undetectable | 1tsnA-4dqvA:21.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fog | THYMIDYLATE SYNTHASE (Mycobacteriumtuberculosis) |
PF00303(Thymidylat_synt) | 9 | HIS A 51SER A 54ILE A 79TRP A 80TRP A 83LEU A 143GLY A 173PHE A 176TYR A 209 | C2F A 302 (-3.9A)C2F A 302 (-3.4A)C2F A 302 (-3.3A)C2F A 302 ( 3.8A)C2F A 302 (-3.9A)C2F A 302 (-4.8A)C2F A 302 (-3.2A)C2F A 302 (-3.7A)C2F A 302 ( 4.6A) | 0.38A | 1tsnA-4fogA:40.7 | 1tsnA-4fogA:66.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gh7 | NEUTROPHILGELATINASE-ASSOCIATED LIPOCALIN (Homo sapiens) |
PF00061(Lipocalin) | 5 | ILE A 153LEU A 159LEU A 137GLY A 35PHE A 168 | None | 1.12A | 1tsnA-4gh7A:undetectable | 1tsnA-4gh7A:21.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h0u | THYMIDYLATE SYNTHASE (Corynebacteriumglutamicum) |
PF00303(Thymidylat_synt) | 6 | HIS A 54LEU A 175GLY A 176PHE A 179TYR A 212VAL A 264 | NoneNoneUMP A 301 (-3.6A)NoneUMP A 301 (-4.5A)None | 0.94A | 1tsnA-4h0uA:38.6 | 1tsnA-4h0uA:63.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h0u | THYMIDYLATE SYNTHASE (Corynebacteriumglutamicum) |
PF00303(Thymidylat_synt) | 5 | HIS A 54SER A 57ILE A 82GLY A 176TYR A 212 | NoneNoneNoneUMP A 301 (-3.6A)UMP A 301 (-4.5A) | 0.83A | 1tsnA-4h0uA:38.6 | 1tsnA-4h0uA:63.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h0u | THYMIDYLATE SYNTHASE (Corynebacteriumglutamicum) |
PF00303(Thymidylat_synt) | 6 | HIS A 54SER A 57ILE A 82TRP A 83LEU A 146GLY A 176 | NoneNoneNoneNoneNoneUMP A 301 (-3.6A) | 0.75A | 1tsnA-4h0uA:38.6 | 1tsnA-4h0uA:63.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h0u | THYMIDYLATE SYNTHASE (Corynebacteriumglutamicum) |
PF00303(Thymidylat_synt) | 5 | HIS A 54SER A 57LEU A 175GLY A 176TYR A 212 | NoneNoneNoneUMP A 301 (-3.6A)UMP A 301 (-4.5A) | 0.70A | 1tsnA-4h0uA:38.6 | 1tsnA-4h0uA:63.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iqq | THYMIDYLATE SYNTHASE (Caenorhabditiselegans) |
PF00303(Thymidylat_synt) | 5 | ILE A 110LEU A 223GLY A 224PHE A 227TYR A 260 | D16 A 402 (-4.0A)D16 A 402 (-3.7A)D16 A 402 ( 3.1A)D16 A 402 (-3.2A)D16 A 402 ( 4.2A) | 0.93A | 1tsnA-4iqqA:36.1 | 1tsnA-4iqqA:44.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iqq | THYMIDYLATE SYNTHASE (Caenorhabditiselegans) |
PF00303(Thymidylat_synt) | 6 | ILE A 110TRP A 111LEU A 194LEU A 223GLY A 224PHE A 227 | D16 A 402 (-4.0A)NoneNoneD16 A 402 (-3.7A)D16 A 402 ( 3.1A)D16 A 402 (-3.2A) | 1.10A | 1tsnA-4iqqA:36.1 | 1tsnA-4iqqA:44.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iu9 | NITRITE EXTRUSIONPROTEIN 2 (Escherichiacoli) |
no annotation | 5 | TRP B 116LEU B 136GLY B 139PHE B 140VAL B 133 | None | 1.13A | 1tsnA-4iu9B:undetectable | 1tsnA-4iu9B:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kr8 | OUTER MEMBRANEPROTEIN F (Salmonellaenterica) |
PF00267(Porin_1) | 5 | TRP A 23GLY A 19TYR A 112VAL A 335ALA A 334 | None | 1.12A | 1tsnA-4kr8A:undetectable | 1tsnA-4kr8A:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lru | GLYOXALASE III(GLUTATHIONE-INDEPENDENT) (Candidaalbicans) |
PF01965(DJ-1_PfpI) | 5 | LEU A 6GLY A 105PHE A 25VAL A 135ALA A 134 | None | 1.04A | 1tsnA-4lruA:undetectable | 1tsnA-4lruA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6q | VOSA (Aspergillusnidulans) |
PF11754(Velvet) | 5 | SER A 100LEU A 77GLY A 96VAL A 44ALA A 31 | None | 1.06A | 1tsnA-4n6qA:undetectable | 1tsnA-4n6qA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pg6 | HOMOSERINEDEHYDROGENASE (Staphylococcusaureus) |
PF00742(Homoserine_dh)PF03447(NAD_binding_3) | 5 | HIS A 59ILE A 67LEU A 90LEU A 8GLY A 10 | NoneNoneNoneNoneDMS A 511 (-3.2A) | 1.06A | 1tsnA-4pg6A:undetectable | 1tsnA-4pg6A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qae | NEUTROPHILGELATINASE-ASSOCIATED LIPOCALIN (Homo sapiens) |
PF00061(Lipocalin) | 5 | ILE A 153LEU A 159LEU A 137GLY A 35PHE A 168 | None | 1.10A | 1tsnA-4qaeA:undetectable | 1tsnA-4qaeA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qyr | AT-LESS POLYKETIDESYNTHASE (Streptomycesplatensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | HIS A2719SER A2803LEU A2898VAL A2781ALA A2552 | None | 1.06A | 1tsnA-4qyrA:undetectable | 1tsnA-4qyrA:15.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rs2 | PREDICTEDACYLTRANSFERASE WITHACYL-COAN-ACYLTRANSFERASEDOMAIN (Escherichiacoli) |
PF13508(Acetyltransf_7) | 5 | LEU A 100LEU A 77PHE A 120VAL A 57ALA A 58 | NoneCOA A 200 ( 4.4A)NoneNoneNone | 1.13A | 1tsnA-4rs2A:undetectable | 1tsnA-4rs2A:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wqe | THIOSULFATEDEHYDROGENASE (Allochromatiumvinosum) |
PF13442(Cytochrome_CBB3) | 5 | HIS A 164ILE A 205LEU A 143LEU A 155GLY A 152 | HEC A1002 (-3.2A)HEC A1002 (-4.0A)NoneNoneNone | 1.01A | 1tsnA-4wqeA:undetectable | 1tsnA-4wqeA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj5 | CYCLIC AMP-GMPSYNTHASE (Vibrio cholerae) |
no annotation | 5 | ILE A 328LEU A 373LEU A 322GLY A 323VAL A 282 | None NA A1015 (-4.1A)NoneEDO A1011 (-3.4A)None | 1.03A | 1tsnA-4xj5A:undetectable | 1tsnA-4xj5A:22.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xsc | THYMIDYLATE SYNTHASE (Humanalphaherpesvirus3) |
PF00303(Thymidylat_synt) | 6 | ILE A 96TRP A 97LEU A 180GLY A 210PHE A 213TYR A 246 | 1PE A1002 (-4.6A)1PE A1002 (-4.7A)BVP A1001 ( 4.5A)BVP A1001 (-3.4A)1PE A1002 (-3.8A)BVP A1001 (-4.5A) | 1.07A | 1tsnA-4xscA:36.4 | 1tsnA-4xscA:40.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xsc | THYMIDYLATE SYNTHASE (Humanalphaherpesvirus3) |
PF00303(Thymidylat_synt) | 6 | ILE A 96TRP A 97LEU A 180LEU A 209GLY A 210TYR A 246 | 1PE A1002 (-4.6A)1PE A1002 (-4.7A)BVP A1001 ( 4.5A)NoneBVP A1001 (-3.4A)BVP A1001 (-4.5A) | 0.74A | 1tsnA-4xscA:36.4 | 1tsnA-4xscA:40.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5but | KTR SYSTEM POTASSIUMUPTAKE PROTEIN A,KTRSYSTEM POTASSIUMUPTAKE PROTEIN A (Bacillussubtilis) |
PF02254(TrkA_N) | 5 | ILE A 37LEU A 66LEU A 14VAL A 42ALA A 52 | None | 1.08A | 1tsnA-5butA:undetectable | 1tsnA-5butA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dqn | CYTOCHROME P450CYP125 (Mycolicibacteriumsmegmatis) |
PF00067(p450) | 5 | ILE A 162LEU A 226LEU A 365GLY A 362ALA A 122 | NoneNoneHEM A 501 (-4.5A)HEM A 501 (-3.5A)None | 1.09A | 1tsnA-5dqnA:undetectable | 1tsnA-5dqnA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eo9 | CG32791, ISOFORM A (Drosophilamelanogaster) |
PF07679(I-set)PF13927(Ig_3) | 5 | ILE B 135LEU B 109GLY B 120PHE B 137ALA B 82 | NoneNoneNoneNAG B 901 ( 4.6A)None | 0.94A | 1tsnA-5eo9B:undetectable | 1tsnA-5eo9B:19.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h3a | ORF70 (Humangammaherpesvirus8) |
PF00303(Thymidylat_synt) | 5 | ILE A 132LEU A 216GLY A 246PHE A 249TYR A 282 | D16 A 401 ( 4.0A)NoneD16 A 401 ( 3.2A)D16 A 401 (-3.4A)UMP A 402 (-4.5A) | 1.08A | 1tsnA-5h3aA:36.3 | 1tsnA-5h3aA:47.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h3a | ORF70 (Humangammaherpesvirus8) |
PF00303(Thymidylat_synt) | 5 | ILE A 132TRP A 133LEU A 216GLY A 246PHE A 249 | D16 A 401 ( 4.0A)NoneNoneD16 A 401 ( 3.2A)D16 A 401 (-3.4A) | 1.01A | 1tsnA-5h3aA:36.3 | 1tsnA-5h3aA:47.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ir2 | CELLULASE (Parabacteroidesjohnsonii) |
PF03737(RraA-like) | 5 | ILE A 194LEU A 203GLY A 197VAL A 49ALA A 48 | None | 1.13A | 1tsnA-5ir2A:undetectable | 1tsnA-5ir2A:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jn9 | CARBONIC ANHYDRASE 4 (Homo sapiens) |
PF00194(Carb_anhydrase) | 5 | HIS A 190LEU A 195GLY A 83TYR A 88ALA A 142 | NoneSO4 A 303 (-4.0A)NoneNoneNone | 1.12A | 1tsnA-5jn9A:undetectable | 1tsnA-5jn9A:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lst | ATP-DEPENDENT DNAHELICASE Q4 (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | HIS A 930ILE A1051LEU A 923VAL A 842ALA A 841 | None | 0.97A | 1tsnA-5lstA:undetectable | 1tsnA-5lstA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mhj | MAJOR VIRALTRANSCRIPTION FACTORICP4 (Humanalphaherpesvirus1) |
PF03584(Herpes_ICP4_N) | 5 | LEU A 380GLY A 464PHE A 465VAL A 452ALA A 453 | None | 1.16A | 1tsnA-5mhjA:undetectable | 1tsnA-5mhjA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mso | CARBOXYLIC ACIDREDUCTASE (Mycobacteriummarinum) |
PF07993(NAD_binding_4) | 5 | SER A 943ILE A 939TYR A1059VAL A 980ALA A 979 | None | 1.09A | 1tsnA-5msoA:undetectable | 1tsnA-5msoA:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6m | APOLIPOPROTEINN-ACYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00795(CN_hydrolase) | 5 | SER A 256ILE A 265GLY A 287VAL A 320ALA A 325 | None | 0.90A | 1tsnA-5n6mA:undetectable | 1tsnA-5n6mA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ns8 | - (-) |
no annotation | 5 | SER A 15ILE A 19LEU A 65GLY A 412VAL A 416 | NOJ A 506 ( 4.0A)NoneSO4 A 502 ( 4.9A)NoneNone | 1.14A | 1tsnA-5ns8A:undetectable | 1tsnA-5ns8A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t0l | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasmagondii) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 8 | ILE A 402TRP A 403LEU A 486LEU A 516GLY A 517PHE A 520TYR A 553ALA A 609 | CB3 A 703 (-3.4A)CB3 A 703 (-4.1A)UMP A 701 (-4.7A)CB3 A 703 (-3.7A)CB3 A 703 ( 3.0A)CB3 A 703 (-3.8A)UMP A 701 (-4.4A)CB3 A 703 (-3.8A) | 0.80A | 1tsnA-5t0lA:39.0 | 1tsnA-5t0lA:24.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vf3 | MAJOR CAPSID PROTEIN (Escherichiavirus T4) |
PF07068(Gp23) | 5 | ILE A 254GLY A 251PHE A 252VAL A 136ALA A 137 | None | 1.09A | 1tsnA-5vf3A:undetectable | 1tsnA-5vf3A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wvg | CHITINASE (Ostriniafurnacalis) |
no annotation | 5 | LEU A 532LEU A 642GLY A 641PHE A 639ALA A 685 | None | 1.03A | 1tsnA-5wvgA:undetectable | 1tsnA-5wvgA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x87 | BESTROPHIN (Klebsiellapneumoniae) |
no annotation | 5 | SER A 246ILE A 245GLY A 61VAL A 54ALA A 55 | None | 1.15A | 1tsnA-5x87A:undetectable | 1tsnA-5x87A:20.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6auj | THYMIDYLATE SYNTHASE (Elizabethkingiaanophelis) |
PF00303(Thymidylat_synt) | 6 | HIS A 59SER A 62ILE A 87GLY A 181PHE A 184TYR A 217 | NoneNonePGE A 301 ( 4.2A)PGE A 301 ( 4.0A)PGE A 301 (-3.7A)None | 1.22A | 1tsnA-6aujA:35.6 | 1tsnA-6aujA:65.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6auj | THYMIDYLATE SYNTHASE (Elizabethkingiaanophelis) |
PF00303(Thymidylat_synt) | 5 | HIS A 59SER A 62ILE A 87TRP A 88LEU A 151 | NoneNonePGE A 301 ( 4.2A)PGE A 301 (-3.5A)None | 0.69A | 1tsnA-6aujA:35.6 | 1tsnA-6aujA:65.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6auj | THYMIDYLATE SYNTHASE (Elizabethkingiaanophelis) |
PF00303(Thymidylat_synt) | 5 | HIS A 59SER A 62ILE A 87TRP A 88PHE A 184 | NoneNonePGE A 301 ( 4.2A)PGE A 301 (-3.5A)PGE A 301 (-3.7A) | 0.90A | 1tsnA-6aujA:35.6 | 1tsnA-6aujA:65.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b2q | SERINE/THREONINE-PROTEIN KINASE PKNA (Mycobacteriumtuberculosis) |
no annotation | 6 | HIS A 117SER A 114LEU A 122GLY A 207VAL A 271ALA A 270 | 0BD A 302 (-3.7A)NoneNoneNoneNoneNone | 1.48A | 1tsnA-6b2qA:undetectable | 1tsnA-6b2qA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cdz | THYMIDYLATE SYNTHASE (Escherichiacoli) |
no annotation | 7 | SER A 54ILE A 79LEU A 143LEU A 172GLY A 173PHE A 176TYR A 209 | NoneCB3 A 701 (-3.9A)NoneCB3 A 701 (-3.5A)CB3 A 701 (-3.3A)CB3 A 701 (-3.8A)UMP A 702 ( 4.2A) | 1.09A | 1tsnA-6cdzA:41.9 | 1tsnA-6cdzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cdz | THYMIDYLATE SYNTHASE (Escherichiacoli) |
no annotation | 6 | SER A 54ILE A 79LEU A 172GLY A 173PHE A 176VAL A 262 | NoneCB3 A 701 (-3.9A)CB3 A 701 (-3.5A)CB3 A 701 (-3.3A)CB3 A 701 (-3.8A)None | 1.32A | 1tsnA-6cdzA:41.9 | 1tsnA-6cdzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cdz | THYMIDYLATE SYNTHASE (Escherichiacoli) |
no annotation | 7 | SER A 54ILE A 79TRP A 80LEU A 143LEU A 172GLY A 173PHE A 176 | NoneCB3 A 701 (-3.9A)NoneNoneCB3 A 701 (-3.5A)CB3 A 701 (-3.3A)CB3 A 701 (-3.8A) | 1.07A | 1tsnA-6cdzA:41.9 | 1tsnA-6cdzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gun | - (-) |
no annotation | 5 | LEU A 288GLY A 157PHE A 160TYR A 98ALA A 60 | None | 1.14A | 1tsnA-6gunA:undetectable | 1tsnA-6gunA:undetectable |