SIMILAR PATTERNS OF AMINO ACIDS FOR 1TNL_A_TPAA900_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a0j TRYPSIN

(Salmo salar)
PF00089
(Trypsin)
6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
0.22A 1tnlA-1a0jA:
41.5
1tnlA-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a5i PLASMINOGEN
ACTIVATOR


(Desmodus
rotundus)
PF00089
(Trypsin)
4 ASP A 189
SER A 195
GLY A 216
GLY A 226
0GJ  A 245 (-3.1A)
0GJ  A 245 (-1.4A)
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
0.38A 1tnlA-1a5iA:
31.4
1tnlA-1a5iA:
36.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1afq BOVINE
GAMMA-CHYMOTRYPSIN


(Bos taurus)
PF00089
(Trypsin)
5 SER C 190
SER C 195
VAL C 213
GLY C 216
GLY C 226
None
0FG  C 301 ( 3.0A)
None
0FG  C 301 (-3.4A)
0FG  C 301 ( 4.4A)
0.54A 1tnlA-1afqC:
11.3
1tnlA-1afqC:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bqy PLASMINOGEN
ACTIVATOR


(Trimeresurus
stejnegeri)
PF00089
(Trypsin)
5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
0.40A 1tnlA-1bqyA:
35.5
1tnlA-1bqyA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bru ELASTASE

(Sus scrofa)
PF00089
(Trypsin)
4 SER P 190
SER P 195
VAL P 213
GLY P 216
1NB  P   1 (-3.5A)
1NB  P   1 ( 1.2A)
None
1NB  P   1 ( 4.4A)
0.48A 1tnlA-1bruP:
16.5
1tnlA-1bruP:
40.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cte CATHEPSIN B

(Rattus
norvegicus)
PF00112
(Peptidase_C1)
5 SER A  90
SER A  39
VAL A  52
GLY A  92
GLY A  99
None
1.09A 1tnlA-1cteA:
undetectable
1tnlA-1cteA:
18.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dlk THROMBIN HEAVY CHAIN

(Bos taurus)
PF00089
(Trypsin)
5 SER B 190
SER B 195
VAL B 213
GLY B 216
GLY B 226
None
0.57A 1tnlA-1dlkB:
36.5
1tnlA-1dlkB:
43.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ekb ENTEROPEPTIDASE

(Bos taurus)
PF00089
(Trypsin)
5 ASP B 189
SER B 190
SER B 195
GLY B 216
GLY B 226
None
0.28A 1tnlA-1ekbB:
36.4
1tnlA-1ekbB:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1elv COMPLEMENT C1S
COMPONENT


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
6 ASP A 611
SER A 612
SER A 617
VAL A 638
GLY A 641
GLY A 648
None
None
SO4  A2001 ( 2.7A)
None
None
None
0.29A 1tnlA-1elvA:
10.8
1tnlA-1elvA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ept PORCINE E-TRYPSIN

(Sus scrofa)
PF00089
(Trypsin)
6 ASP C 189
SER C 190
SER C 195
VAL C 213
GLY C 216
GLY C 226
None
0.23A 1tnlA-1eptC:
16.1
1tnlA-1eptC:
81.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1euf DUODENASE

(Bos taurus)
PF00089
(Trypsin)
4 SER A 190
SER A 195
VAL A 213
GLY A 216
None
0.38A 1tnlA-1eufA:
35.9
1tnlA-1eufA:
38.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fi8 NATURAL KILLER CELL
PROTEASE 1


(Rattus
norvegicus)
PF00089
(Trypsin)
4 SER A 190
SER A 195
VAL A 213
GLY A 216
None
0.33A 1tnlA-1fi8A:
36.0
1tnlA-1fi8A:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiw BETA-ACROSIN HEAVY
CHAIN


(Ovis aries)
PF00089
(Trypsin)
4 ASP A 189
SER A 195
GLY A 216
GLY A 226
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
0.35A 1tnlA-1fiwA:
16.2
1tnlA-1fiwA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiz BETA-ACROSIN HEAVY
CHAIN


(Sus scrofa)
PF00089
(Trypsin)
4 ASP A 189
SER A 195
GLY A 216
GLY A 226
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.32A 1tnlA-1fizA:
17.0
1tnlA-1fizA:
37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fq3 GRANZYME B

(Homo sapiens)
PF00089
(Trypsin)
4 SER A 190
SER A 195
VAL A 213
GLY A 216
None
SO4  A 800 (-2.4A)
None
None
0.69A 1tnlA-1fq3A:
11.4
1tnlA-1fq3A:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA


(Homo sapiens)
PF00089
(Trypsin)
6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
0.29A 1tnlA-1fxyA:
38.1
1tnlA-1fxyA:
55.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE


(Pseudomonas
putida)
PF00221
(Lyase_aromatic)
5 ASP A 145
SER A 200
VAL A 334
GLY A 329
GLY A 141
None
1.09A 1tnlA-1gk2A:
undetectable
1tnlA-1gk2A:
17.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gvl KALLIKREIN 6

(Homo sapiens)
PF00089
(Trypsin)
4 SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.55A 1tnlA-1gvlA:
28.3
1tnlA-1gvlA:
44.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4w TRYPSIN IVA

(Homo sapiens)
PF00089
(Trypsin)
6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
BEN  A 250 (-2.9A)
BEN  A 250 (-2.9A)
BEN  A 250 (-3.6A)
None
BEN  A 250 (-3.9A)
BEN  A 250 (-3.3A)
0.20A 1tnlA-1h4wA:
43.2
1tnlA-1h4wA:
72.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h9h TRYPSIN

(Sus scrofa)
PF00089
(Trypsin)
6 ASP E 189
SER E 190
SER E 195
VAL E 213
GLY E 216
GLY E 226
None
0.28A 1tnlA-1h9hE:
43.0
1tnlA-1h9hE:
82.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1id5 THROMBIN

(Bos taurus)
PF00089
(Trypsin)
5 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
None
0.47A 1tnlA-1id5H:
34.3
1tnlA-1id5H:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus)
PF00089
(Trypsin)
5 ASP T 189
SER T 195
VAL T 213
GLY T 216
GLY T 226
ZEN  T   1 ( 3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
0.20A 1tnlA-1j17T:
43.0
1tnlA-1j17T:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kig FACTOR XA

(Bos taurus)
PF00089
(Trypsin)
5 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
None
0.43A 1tnlA-1kigH:
34.3
1tnlA-1kigH:
40.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mbq TRYPSIN

(Oncorhynchus
keta)
PF00089
(Trypsin)
6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
BEN  A1222 (-2.9A)
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
0.26A 1tnlA-1mbqA:
41.0
1tnlA-1mbqA:
65.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1npm NEUROPSIN

(Mus musculus)
PF00089
(Trypsin)
4 ASP A 189
SER A 195
GLY A 216
GLY A 226
None
0.40A 1tnlA-1npmA:
37.7
1tnlA-1npmA:
45.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o5f SERINE PROTEASE
HEPSIN


(Homo sapiens)
PF00089
(Trypsin)
5 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
CR9  H 256 (-2.4A)
CR9  H 256 (-1.5A)
CR9  H 256 (-4.3A)
CR9  H 256 ( 3.8A)
CR9  H 256 (-3.0A)
0.23A 1tnlA-1o5fH:
19.2
1tnlA-1o5fH:
41.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1op2 VENOM SERINE
PROTEINASE


(Deinagkistrodon
acutus)
PF00089
(Trypsin)
5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.48A 1tnlA-1op2A:
34.5
1tnlA-1op2A:
41.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1orf GRANZYME A

(Homo sapiens)
PF00089
(Trypsin)
5 ASP A 189
SER A 190
SER A 195
GLY A 216
GLY A 226
0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
0.31A 1tnlA-1orfA:
12.8
1tnlA-1orfA:
35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pfx FACTOR IXA

(Sus scrofa)
PF00089
(Trypsin)
5 ASP C 189
SER C 190
SER C 195
GLY C 216
GLY C 226
0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
0.44A 1tnlA-1pfxC:
34.8
1tnlA-1pfxC:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pq5 TRYPSIN

(Fusarium
oxysporum)
PF00089
(Trypsin)
6 ASP A 189
SER A 190
SER A 195
VAL A 210
GLY A 213
GLY A 223
ARG  A 703 (-2.0A)
ARG  A 703 (-2.5A)
ARG  A 703 (-2.3A)
ARG  A 703 (-4.5A)
ARG  A 703 ( 3.7A)
ARG  A 703 (-2.6A)
0.28A 1tnlA-1pq5A:
34.0
1tnlA-1pq5A:
44.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
6 ASP A 627
SER A 628
SER A 633
VAL A 653
GLY A 656
GLY A 667
NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
0.31A 1tnlA-1q3xA:
34.0
1tnlA-1q3xA:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sgf NERVE GROWTH FACTOR

(Mus musculus)
PF00089
(Trypsin)
4 ASP G 189
SER G 195
GLY G 216
GLY G 226
None
0.45A 1tnlA-1sgfG:
36.7
1tnlA-1sgfG:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ym0 FIBRINOTIC ENZYME
COMPONENT B


(Eisenia fetida)
PF00089
(Trypsin)
6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.27A 1tnlA-1ym0A:
36.1
1tnlA-1ym0A:
39.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zca G ALPHA I/12

(Mus musculus)
PF00503
(G-alpha)
4 SER A  66
SER A  69
GLY A 228
GLY A  62
GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
0.77A 1tnlA-1zcaA:
undetectable
1tnlA-1zcaA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
4 SER A 633
VAL A 653
GLY A 656
GLY A 667
None
0.66A 1tnlA-1zjkA:
29.7
1tnlA-1zjkA:
26.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zlr COAGULATION FACTOR
XI


(Homo sapiens)
PF00089
(Trypsin)
4 ASP A 189
SER A 195
GLY A 216
GLY A 226
368  A 901 (-2.8A)
368  A 901 (-1.4A)
368  A 901 (-3.6A)
368  A 901 (-3.5A)
0.27A 1tnlA-1zlrA:
33.7
1tnlA-1zlrA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aip PROTEIN C ACTIVATOR

(Agkistrodon
contortrix)
PF00089
(Trypsin)
4 ASP A 189
SER A 195
GLY A 216
GLY A 226
None
SO4  A 301 (-2.8A)
None
None
0.67A 1tnlA-2aipA:
33.9
1tnlA-2aipA:
39.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1


(Homo sapiens)
PF10433
(MMS1_N)
4 ASP A 654
SER A 653
GLY A 609
GLY A 632
None
0.75A 1tnlA-2b5nA:
undetectable
1tnlA-2b5nA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eek TRYPSIN-1

(Gadus morhua)
PF00089
(Trypsin)
6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
BEN  A 301 (-2.7A)
BEN  A 301 (-2.8A)
BEN  A 301 (-3.4A)
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
0.25A 1tnlA-2eekA:
40.3
1tnlA-2eekA:
62.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN


(Homo sapiens)
PF00089
(Trypsin)
5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.45A 1tnlA-2ei8A:
35.6
1tnlA-2ei8A:
38.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f91 HEPATOPANCREAS
TRYPSIN


(Astacus
leptodactylus)
PF00089
(Trypsin)
6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 227
None
0.25A 1tnlA-2f91A:
36.6
1tnlA-2f91A:
44.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou MAJOR TROPISM
DETERMINANT P1


(Bordetella
virus BPP1)
no annotation 4 SER A 271
VAL A 276
GLY A 285
GLY A 273
None
0.74A 1tnlA-2iouA:
undetectable
1tnlA-2iouA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipp CATHEPSIN B

(Homo sapiens)
PF00112
(Peptidase_C1)
4 SER A  39
VAL B  52
GLY B  92
GLY B  99
None
0.77A 1tnlA-2ippA:
undetectable
1tnlA-2ippA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jet CHYMOTRYPSINOGEN B
CHAIN C


(Rattus
norvegicus)
PF00089
(Trypsin)
4 SER C 195
VAL C 213
GLY C 216
GLY C 226
None
0.64A 1tnlA-2jetC:
9.4
1tnlA-2jetC:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E


(Homo sapiens)
PF00089
(Trypsin)
5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
0.25A 1tnlA-2oq5A:
14.3
1tnlA-2oq5A:
37.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pks THROMBIN HEAVY CHAIN
FRAGMENT


(Homo sapiens)
PF00089
(Trypsin)
5 ASP C 229
SER C 235
VAL C 255
GLY C 258
GLY C 268
G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
None
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
0.33A 1tnlA-2pksC:
12.1
1tnlA-2pksC:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psy KALLIKREIN-5

(Homo sapiens)
PF00089
(Trypsin)
6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.34A 1tnlA-2psyA:
38.6
1tnlA-2psyA:
47.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC


(Escherichia
coli)
PF01032
(FecCD)
5 SER A  94
SER A 246
VAL A 243
GLY A 254
GLY A  89
None
1.35A 1tnlA-2qi9A:
undetectable
1tnlA-2qi9A:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qy0 COMPLEMENT C1R
SUBCOMPONENT


(Homo sapiens)
PF00089
(Trypsin)
5 ASP B 631
SER B 637
VAL B 657
GLY B 660
GLY B 668
None
0.47A 1tnlA-2qy0B:
32.0
1tnlA-2qy0B:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR


(Homo sapiens)
PF00089
(Trypsin)
4 ASP A 189
SER A 195
GLY A 216
GLY A 226
None
0.33A 1tnlA-2r0lA:
18.4
1tnlA-2r0lA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE


(Homo sapiens)
PF00089
(Trypsin)
6 ASP U 189
SER U 190
SER U 195
VAL U 213
GLY U 216
GLY U 226
4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
0.64A 1tnlA-2r2wU:
15.6
1tnlA-2r2wU:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN


(Homo sapiens)
PF00089
(Trypsin)
5 ASP S 189
SER S 190
SER S 195
GLY S 216
GLY S 226
None
0.25A 1tnlA-2wpmS:
36.0
1tnlA-2wpmS:
41.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT


(Arabidopsis
thaliana)
PF00503
(G-alpha)
4 SER A  49
SER A  52
GLY A 221
GLY A  45
GSP  A1382 (-3.4A)
MG  A1381 ( 2.0A)
GSP  A1382 (-3.4A)
None
0.75A 1tnlA-2xtzA:
undetectable
1tnlA-2xtzA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zec TRYPTASE BETA 2

(Homo sapiens)
PF00089
(Trypsin)
6 ASP A 203
SER A 204
SER A 209
VAL A 227
GLY A 230
GLY A 240
11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
0.36A 1tnlA-2zecA:
32.7
1tnlA-2zecA:
40.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN


(Thermus
thermophilus)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
4 SER A 634
VAL A 601
GLY A 704
GLY A 708
None
0.72A 1tnlA-3aqpA:
undetectable
1tnlA-3aqpA:
14.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3beu TRYPSIN

(Streptomyces
griseus)
PF00089
(Trypsin)
5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
0.29A 1tnlA-3beuA:
32.1
1tnlA-3beuA:
36.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu1 LIPOCALIN

(Argas
monolakensis)
PF02098
(His_binding)
5 ASP A  94
SER A  88
SER A   8
VAL A   7
GLY A  15
HSM  A 301 (-2.9A)
None
None
None
None
1.38A 1tnlA-3bu1A:
undetectable
1tnlA-3bu1A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT


(Mus musculus)
PF00503
(G-alpha)
4 SER A  59
SER A  62
GLY A 225
GLY A  55
GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
0.75A 1tnlA-3cx6A:
undetectable
1tnlA-3cx6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT


(Mus musculus)
PF00503
(G-alpha)
5 SER A 268
SER A 248
VAL A 247
GLY A  57
GLY A  55
None
None
None
GDP  A 775 ( 4.2A)
None
1.19A 1tnlA-3cx6A:
undetectable
1tnlA-3cx6A:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN


(Homo sapiens)
PF00089
(Trypsin)
5 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.40A 1tnlA-3f6uH:
35.2
1tnlA-3f6uH:
35.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE


(Brucella
abortus)
PF13561
(adh_short_C2)
4 SER A 145
VAL A 166
GLY A 160
GLY A 149
None
0.69A 1tnlA-3gafA:
undetectable
1tnlA-3gafA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gov MASP-1

(Homo sapiens)
PF00089
(Trypsin)
5 ASP B 640
SER B 646
VAL B 666
GLY B 669
GLY B 679
None
0.47A 1tnlA-3govB:
35.4
1tnlA-3govB:
35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gym PROSTASIN

(Homo sapiens)
PF00089
(Trypsin)
5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.31A 1tnlA-3gymA:
34.8
1tnlA-3gymA:
40.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1


(Rattus
norvegicus)
PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec)
4 ASP A2570
VAL A2538
GLY A2546
GLY A2548
None
0.67A 1tnlA-3javA:
undetectable
1tnlA-3javA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE


(Bacteroides
ovatus)
no annotation 4 SER A 290
SER A 224
GLY A 239
GLY A 270
None
0.73A 1tnlA-3n6zA:
undetectable
1tnlA-3n6zA:
22.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens)
PF00089
(Trypsin)
5 ASP B 189
SER B 195
VAL B 213
GLY B 216
GLY B 226
None
0.47A 1tnlA-3r3gB:
34.1
1tnlA-3r3gB:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE


(Gloydius
saxatilis)
PF00089
(Trypsin)
5 ASP A 189
SER A 195
VAL A 209
GLY A 212
GLY A 223
None
0.50A 1tnlA-3s69A:
35.0
1tnlA-3s69A:
43.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s9b VIPERA RUSSELLI
PROTEINASE RVV-V
GAMMA


(Daboia
siamensis)
PF00089
(Trypsin)
4 ASP A 189
SER A 195
VAL A 213
GLY A 216
None
0.71A 1tnlA-3s9bA:
12.8
1tnlA-3s9bA:
40.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w94 ENTEROPEPTIDASE-1

(Oryzias latipes)
PF00089
(Trypsin)
5 ASP A 973
SER A 974
SER A 979
GLY A1000
GLY A1010
None
0.24A 1tnlA-3w94A:
36.9
1tnlA-3w94A:
35.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjc GTPASE IMAP FAMILY
MEMBER 7


(Homo sapiens)
PF04548
(AIG1)
4 SER A  19
SER A  22
GLY A  66
GLY A  15
GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
0.72A 1tnlA-3zjcA:
undetectable
1tnlA-3zjcA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis)
PF00089
(Trypsin)
PF14670
(FXa_inhibition)
5 ASP A 356
SER A 362
VAL A 380
GLY A 383
GLY A 393
0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
0.34A 1tnlA-4bxwA:
32.8
1tnlA-4bxwA:
25.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d9r COMPLEMENT FACTOR D

(Homo sapiens)
PF00089
(Trypsin)
5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
None
0.61A 1tnlA-4d9rA:
16.3
1tnlA-4d9rA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN


(Homo sapiens)
PF00089
(Trypsin)
5 ASP A 181
SER A 182
SER A 187
GLY A 208
GLY A 218
None
0.57A 1tnlA-4dgjA:
36.8
1tnlA-4dgjA:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN


(Homo sapiens)
PF00089
(Trypsin)
5 ASP H 627
SER H 628
VAL H 653
GLY H 656
GLY H 667
None
0.38A 1tnlA-4fxgH:
33.4
1tnlA-4fxgH:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1


(Bothrops
jararacussu)
PF00089
(Trypsin)
5 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
None
0.52A 1tnlA-4gsoA:
undetectable
1tnlA-4gsoA:
43.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2


(Escherichia
coli)
no annotation 4 SER B 272
VAL B 176
GLY B 299
GLY B 295
None
0.76A 1tnlA-4iu9B:
undetectable
1tnlA-4iu9B:
16.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3


(Homo sapiens)
PF00089
(Trypsin)
5 ASP E 639
SER E 645
VAL E 665
GLY E 668
GLY E 680
None
0.42A 1tnlA-4iw4E:
33.7
1tnlA-4iw4E:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k8y KALLIKREIN-4

(Homo sapiens)
PF00089
(Trypsin)
6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.38A 1tnlA-4k8yA:
37.0
1tnlA-4k8yA:
40.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m7g TRYPSIN-LIKE
PROTEASE


(Saccharopolyspora
erythraea)
PF00089
(Trypsin)
4 ASP A 173
SER A 179
GLY A 196
GLY A 206
None
0.16A 1tnlA-4m7gA:
33.9
1tnlA-4m7gA:
40.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP1
COXSACKIEVIRUS
CAPSID PROTEIN VP2


(Enterovirus C)
PF00073
(Rhv)
5 ASP 1 287
SER 2 141
VAL 1 234
GLY 1 283
GLY 1 285
None
None
HEZ  15003 ( 4.7A)
None
None
1.24A 1tnlA-4q4y1:
undetectable
1tnlA-4q4y1:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qed ELXO

(Staphylococcus
epidermidis)
PF13561
(adh_short_C2)
4 SER A 139
VAL A 160
GLY A 154
GLY A 143
None
0.76A 1tnlA-4qedA:
undetectable
1tnlA-4qedA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN


(Homo sapiens)
PF00089
(Trypsin)
6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
3KM  A 900 (-2.9A)
3KM  A 900 (-2.9A)
3KM  A 900 (-3.6A)
None
3KM  A 900 (-3.4A)
3KM  A 900 (-3.2A)
0.22A 1tnlA-4r0iA:
37.5
1tnlA-4r0iA:
39.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wwy TRYPSIN-1

(Homo sapiens)
PF00089
(Trypsin)
6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.25A 1tnlA-4wwyA:
42.0
1tnlA-4wwyA:
74.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ylq COAGULATION FACTOR
VII


(Homo sapiens)
PF00089
(Trypsin)
6 ASP H 189
SER H 190
SER H 195
VAL H 213
GLY H 216
GLY H 226
0Z7  H 501 (-2.3A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
0.26A 1tnlA-4ylqH:
35.4
1tnlA-4ylqH:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN


(Homo sapiens)
PF00089
(Trypsin)
4 ASP A 189
SER A 195
GLY A 216
GLY A 226
None
0.41A 1tnlA-5f8zA:
34.3
1tnlA-5f8zA:
41.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fah KALLIKREIN-7

(Homo sapiens)
PF00089
(Trypsin)
4 SER A 195
VAL A 213
GLY A 216
GLY A 226
5VT  A 302 (-4.0A)
None
5VT  A 302 (-3.4A)
5VT  A 302 ( 4.3A)
0.74A 1tnlA-5fahA:
18.2
1tnlA-5fahA:
41.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fcr COMPLEMENT FACTOR D

(Mus musculus)
PF00089
(Trypsin)
4 ASP A 189
SER A 195
VAL A 213
GLY A 226
None
0.70A 1tnlA-5fcrA:
13.0
1tnlA-5fcrA:
36.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN


(Thermococcus
onnurineus)
PF14336
(DUF4392)
5 ASP A  61
SER A 196
VAL A 155
GLY A  65
GLY A  62
None
1.40A 1tnlA-5gkxA:
undetectable
1tnlA-5gkxA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus)
no annotation 4 ASP A 189
SER A 195
GLY A 216
GLY A 226
None
0.54A 1tnlA-5gvtA:
33.3
1tnlA-5gvtA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcx (-)-ISOPIPERITENONE
REDUCTASE


(Mentha x
piperita)
PF00106
(adh_short)
4 SER A 241
VAL A 151
GLY A  98
GLY A 146
None
0.78A 1tnlA-5lcxA:
undetectable
1tnlA-5lcxA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECF


(Escherichia
coli)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
4 ASP F 213
SER F 214
VAL F 173
GLY F 284
None
0.63A 1tnlA-5mg3F:
undetectable
1tnlA-5mg3F:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ms3 KALLIKREIN-8

(Homo sapiens)
no annotation 4 ASP A 189
SER A 195
GLY A 216
GLY A 226
None
0.35A 1tnlA-5ms3A:
38.2
1tnlA-5ms3A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY


(Caulobacter
vibrioides)
no annotation 4 ASP A 486
SER A 505
GLY A 457
GLY A 452
None
0.74A 1tnlA-5oynA:
undetectable
1tnlA-5oynA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN


(Homo sapiens)
PF00089
(Trypsin)
PF09064
(Tme5_EGF_like)
5 ASP B 214
SER B 220
VAL B 240
GLY B 243
GLY B 253
0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
0.25A 1tnlA-5to3B:
34.7
1tnlA-5to3B:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ


(Pseudomonas
aeruginosa)
PF01804
(Penicil_amidase)
4 SER A 327
VAL A 325
GLY A 456
GLY A 454
None
None
83M  A 801 (-4.8A)
None
0.76A 1tnlA-5ubkA:
undetectable
1tnlA-5ubkA:
15.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ubm COMPLEMENT C1S
SUBCOMPONENT


(Homo sapiens)
no annotation 6 ASP A 626
SER A 627
SER A 632
VAL A 653
GLY A 656
GLY A 663
None
0.42A 1tnlA-5ubmA:
11.9
1tnlA-5ubmA:
33.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrf SNAKE VENOM SERINE
PROTEASE DA-36


(Deinagkistrodon
acutus)
no annotation 5 ASP A 200
SER A 206
VAL A 220
GLY A 223
GLY A 234
None
0.66A 1tnlA-5xrfA:
13.3
1tnlA-5xrfA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zfh KALLIKREIN-7

(Mus musculus)
no annotation 4 SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.29A 1tnlA-5zfhA:
37.6
1tnlA-5zfhA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(S) SUBUNIT
ALPHA ISOFORMS SHORT


(Homo sapiens)
no annotation 4 SER A  51
SER A  54
GLY A 226
GLY A  47
GDP  A 401 (-3.4A)
MG  A 402 ( 2.1A)
None
None
0.68A 1tnlA-6au6A:
undetectable
1tnlA-6au6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII


(Homo sapiens)
no annotation 4 ASP B 189
SER B 195
GLY B 216
GLY B 226
BEN  B 301 (-2.7A)
SO4  B 304 ( 2.5A)
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
0.23A 1tnlA-6b74B:
13.8
1tnlA-6b74B:
16.74