SIMILAR PATTERNS OF AMINO ACIDS FOR 1TMX_A_BEZA881_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b48 | PROTEIN (GLUTATHIONES-TRANSFERASE) (Mus musculus) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | GLY A 150TYR A 95ILE A 92ARG A 91HIS A 143 | None | 1.32A | 1tmxA-1b48A:undetectable | 1tmxA-1b48A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dgj | ALDEHYDEOXIDOREDUCTASE (Desulfovibriodesulfuricans) |
PF00111(Fer2)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2) | 5 | LEU A 628ASP A 632GLY A 695PRO A 696VAL A 705 | None | 1.24A | 1tmxA-1dgjA:undetectable | 1tmxA-1dgjA:15.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dj2 | ADENYLOSUCCINATESYNTHETASE (Arabidopsisthaliana) |
PF00709(Adenylsucc_synt) | 5 | LEU A 270GLY A 240ARG A 50HIS A 59VAL A 91 | NoneNoneNoneGDP A 500 (-3.2A)None | 1.31A | 1tmxA-1dj2A:undetectable | 1tmxA-1dj2A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dlm | CATECHOL1,2-DIOXYGENASE (Acinetobactersp. ADP1) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 7 | ASP A 81GLY A 107PRO A 108TYR A 164TYR A 200HIS A 224HIS A 226 | NoneNoneNone FE A 400 (-4.1A) FE A 400 (-4.4A) FE A 400 (-3.4A) FE A 400 (-3.1A) | 0.97A | 1tmxA-1dlmA:27.8 | 1tmxA-1dlmA:29.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dlm | CATECHOL1,2-DIOXYGENASE (Acinetobactersp. ADP1) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | ASP A 81GLY A 107PRO A 108TYR A 200HIS A 224 | NoneNoneNone FE A 400 (-4.4A) FE A 400 (-3.4A) | 1.43A | 1tmxA-1dlmA:27.8 | 1tmxA-1dlmA:29.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dlm | CATECHOL1,2-DIOXYGENASE (Acinetobactersp. ADP1) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 7 | GLY A 107PRO A 108TYR A 164TYR A 200ARG A 221HIS A 224HIS A 226 | NoneNone FE A 400 (-4.1A) FE A 400 (-4.4A) FE A 400 ( 4.7A) FE A 400 (-3.4A) FE A 400 (-3.1A) | 0.55A | 1tmxA-1dlmA:27.8 | 1tmxA-1dlmA:29.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dlm | CATECHOL1,2-DIOXYGENASE (Acinetobactersp. ADP1) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | LEU A 73GLY A 107ARG A 221HIS A 224HIS A 226 | NoneNone FE A 400 ( 4.7A) FE A 400 (-3.4A) FE A 400 (-3.1A) | 0.99A | 1tmxA-1dlmA:27.8 | 1tmxA-1dlmA:29.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eo9 | PROTOCATECHUATE3,4-DIOXYGENASE BETACHAIN (Acinetobactersp. ADP1) |
PF00775(Dioxygenase_C)PF12391(PCDO_beta_N) | 5 | TYR B 408TYR B 447ARG B 457HIS B 460HIS B 462 | FE B 600 ( 4.1A) FE B 600 ( 4.6A)SO4 B 999 (-4.0A) FE B 600 ( 3.4A) FE B 600 ( 3.4A) | 0.33A | 1tmxA-1eo9B:11.9 | 1tmxA-1eo9B:27.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lu4 | SOLUBLE SECRETEDANTIGEN MPT53 (Mycobacteriumtuberculosis) |
PF00578(AhpC-TSA) | 5 | LEU A1084GLY A1019TYR A1095ILE A1091ARG A1094 | None | 1.23A | 1tmxA-1lu4A:undetectable | 1tmxA-1lu4A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pgs | PEPTIDE-N(4)-(N-ACETYL-BETA-D-GLUCOSAMINYL)ASPARAGINEAMIDASE F (Elizabethkingiameningoseptica) |
PF09112(N-glycanase_N)PF09113(N-glycanase_C) | 5 | GLY A 190TYR A 62ILE A 82ARG A 80VAL A 257 | None | 1.37A | 1tmxA-1pgsA:undetectable | 1tmxA-1pgsA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s9a | CHLOROCATECHOL1,2-DIOXYGENASE (Rhodococcusopacus) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 7 | GLY A 76PRO A 77TYR A 134TYR A 169ARG A 191HIS A 194HIS A 196 | BEZ A 306 ( 3.5A)TAM A 305 ( 4.4A) FE A 300 ( 4.3A) FE A 300 ( 4.5A)BEZ A 306 (-3.8A) FE A 300 ( 3.2A) FE A 300 ( 3.4A) | 0.30A | 1tmxA-1s9aA:28.4 | 1tmxA-1s9aA:30.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s9a | CHLOROCATECHOL1,2-DIOXYGENASE (Rhodococcusopacus) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 6 | LEU A 49GLY A 76TYR A 169ARG A 191HIS A 194HIS A 196 | BEZ A 306 (-4.5A)BEZ A 306 ( 3.5A) FE A 300 ( 4.5A)BEZ A 306 (-3.8A) FE A 300 ( 3.2A) FE A 300 ( 3.4A) | 1.05A | 1tmxA-1s9aA:28.4 | 1tmxA-1s9aA:30.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s9a | CHLOROCATECHOL1,2-DIOXYGENASE (Rhodococcusopacus) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | LEU A 49TYR A 169ILE A 171HIS A 194HIS A 196 | BEZ A 306 (-4.5A) FE A 300 ( 4.5A)None FE A 300 ( 3.2A) FE A 300 ( 3.4A) | 1.02A | 1tmxA-1s9aA:28.4 | 1tmxA-1s9aA:30.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s9a | CHLOROCATECHOL1,2-DIOXYGENASE (Rhodococcusopacus) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 6 | PRO A 77TYR A 134TYR A 169ILE A 171HIS A 194HIS A 196 | TAM A 305 ( 4.4A) FE A 300 ( 4.3A) FE A 300 ( 4.5A)None FE A 300 ( 3.2A) FE A 300 ( 3.4A) | 0.82A | 1tmxA-1s9aA:28.4 | 1tmxA-1s9aA:30.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tmx | HYDROXYQUINOL1,2-DIOXYGENASE (Pimelobactersimplex) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 6 | LEU A 80ASP A 83GLY A 109ILE A 199HIS A 221HIS A 237 | NoneBEZ A 881 (-3.8A)BEZ A 881 (-3.5A)BEZ A 881 (-4.1A) FE A 861 ( 3.3A)None | 1.43A | 1tmxA-1tmxA:42.9 | 1tmxA-1tmxA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tmx | HYDROXYQUINOL1,2-DIOXYGENASE (Pimelobactersimplex) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 9 | LEU A 80ASP A 83GLY A 109PRO A 110ILE A 199ARG A 218HIS A 237HIS A 223VAL A 251 | NoneBEZ A 881 (-3.8A)BEZ A 881 (-3.5A)BEZ A 881 (-4.3A)BEZ A 881 (-4.1A)BEZ A 881 (-3.8A)None FE A 861 ( 3.4A)BEZ A 881 ( 4.8A) | 1.26A | 1tmxA-1tmxA:42.9 | 1tmxA-1tmxA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tmx | HYDROXYQUINOL1,2-DIOXYGENASE (Pimelobactersimplex) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 11 | LEU A 80ASP A 83GLY A 109PRO A 110TYR A 164TYR A 197ILE A 199ARG A 218HIS A 221HIS A 223VAL A 251 | NoneBEZ A 881 (-3.8A)BEZ A 881 (-3.5A)BEZ A 881 (-4.3A) FE A 861 (-4.2A) FE A 861 ( 4.4A)BEZ A 881 (-4.1A)BEZ A 881 (-3.8A) FE A 861 ( 3.3A) FE A 861 ( 3.4A)BEZ A 881 ( 4.8A) | 0.00A | 1tmxA-1tmxA:42.9 | 1tmxA-1tmxA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpb | PUTATIVE MODULATOROF DNA GYRASE (Bacteroidesthetaiotaomicron) |
PF01523(PmbA_TldD) | 5 | LEU A 340ASP A 284GLY A 336ILE A 309ARG A 307 | None | 1.33A | 1tmxA-1vpbA:undetectable | 1tmxA-1vpbA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xp3 | ENDONUCLEASE IV (Bacillusanthracis) |
PF01261(AP_endonuc_2) | 5 | LEU A 259TYR A 240ILE A 233HIS A 244HIS A 248 | None | 1.48A | 1tmxA-1xp3A:undetectable | 1tmxA-1xp3A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zej | 3-HYDROXYACYL-COADEHYDROGENASE (Archaeoglobusfulgidus) |
PF00725(3HCDH)PF02737(3HCDH_N) | 5 | LEU A 209GLY A 249TYR A 264ILE A 212VAL A 216 | None | 1.44A | 1tmxA-1zejA:undetectable | 1tmxA-1zejA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2azq | CATECHOL1,2-DIOXYGENASE (Pseudomonasputida) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 7 | GLY A 106PRO A 107TYR A 162TYR A 196ARG A 217HIS A 220HIS A 222 | NoneNone FE A 400 (-4.1A) FE A 400 (-4.4A) FE A 400 (-4.2A) FE A 400 (-3.6A) FE A 400 (-3.2A) | 0.47A | 1tmxA-2azqA:27.3 | 1tmxA-2azqA:29.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2azq | CATECHOL1,2-DIOXYGENASE (Pseudomonasputida) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | LEU A 72GLY A 106ARG A 217HIS A 220HIS A 222 | NoneNone FE A 400 (-4.2A) FE A 400 (-3.6A) FE A 400 (-3.2A) | 0.94A | 1tmxA-2azqA:27.3 | 1tmxA-2azqA:29.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2boy | 3-CHLOROCATECHOL1,2-DIOXYGENASE (Rhodococcusopacus) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 7 | GLY A 76PRO A 77TYR A 133TYR A 167ARG A 188HIS A 191HIS A 193 | BHO A1256 ( 3.7A)BHO A1256 (-4.6A) FE A1255 ( 4.2A) FE A1255 ( 4.3A)BHO A1256 (-3.4A) FE A1255 ( 3.2A) FE A1255 ( 3.4A) | 0.40A | 1tmxA-2boyA:27.8 | 1tmxA-2boyA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2boy | 3-CHLOROCATECHOL1,2-DIOXYGENASE (Rhodococcusopacus) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 6 | LEU A 49GLY A 76TYR A 167ARG A 188HIS A 191HIS A 193 | NoneBHO A1256 ( 3.7A) FE A1255 ( 4.3A)BHO A1256 (-3.4A) FE A1255 ( 3.2A) FE A1255 ( 3.4A) | 0.96A | 1tmxA-2boyA:27.8 | 1tmxA-2boyA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2boy | 3-CHLOROCATECHOL1,2-DIOXYGENASE (Rhodococcusopacus) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 6 | LEU A 49TYR A 167ILE A 169ARG A 188HIS A 191HIS A 193 | None FE A1255 ( 4.3A)NoneBHO A1256 (-3.4A) FE A1255 ( 3.2A) FE A1255 ( 3.4A) | 1.06A | 1tmxA-2boyA:27.8 | 1tmxA-2boyA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2boy | 3-CHLOROCATECHOL1,2-DIOXYGENASE (Rhodococcusopacus) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 7 | PRO A 77TYR A 133TYR A 167ILE A 169ARG A 188HIS A 191HIS A 193 | BHO A1256 (-4.6A) FE A1255 ( 4.2A) FE A1255 ( 4.3A)NoneBHO A1256 (-3.4A) FE A1255 ( 3.2A) FE A1255 ( 3.4A) | 0.92A | 1tmxA-2boyA:27.8 | 1tmxA-2boyA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ddh | ACYL-COA OXIDASE (Rattusnorvegicus) |
PF01756(ACOX)PF02770(Acyl-CoA_dh_M)PF14749(Acyl-CoA_ox_N) | 5 | LEU A 240GLY A 181ILE A 209ARG A 210HIS A 215 | None | 1.28A | 1tmxA-2ddhA:undetectable | 1tmxA-2ddhA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ean | CONNECTOR ENHANCEROF KINASE SUPPRESSOROF RAS 2 (Homo sapiens) |
PF00536(SAM_1) | 5 | LEU A 27GLY A 61ILE A 66HIS A 49VAL A 57 | None | 1.04A | 1tmxA-2eanA:undetectable | 1tmxA-2eanA:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ef4 | ARGINASE (Thermusthermophilus) |
PF00491(Arginase) | 5 | LEU A 268PRO A 233ARG A 18HIS A 136VAL A 20 | None | 1.13A | 1tmxA-2ef4A:undetectable | 1tmxA-2ef4A:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ei0 | 1,2-DIHYDROXYNAPHTHALENE DIOXYGENASE (Pseudomonas sp.C18) |
PF00903(Glyoxalase) | 5 | LEU A 31GLY A 268PRO A 267TYR A 256HIS A 152 | NoneNoneNoneBP7 A 400 ( 4.7A)FE2 A 399 ( 3.4A) | 1.37A | 1tmxA-2ei0A:undetectable | 1tmxA-2ei0A:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gre | DEBLOCKINGAMINOPEPTIDASE (Bacillus cereus) |
PF05343(Peptidase_M42) | 5 | LEU A 88GLY A 74ILE A 118HIS A 184VAL A 99 | None | 1.15A | 1tmxA-2greA:undetectable | 1tmxA-2greA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hnh | DNA POLYMERASE IIIALPHA SUBUNIT (Escherichiacoli) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 5 | LEU A 557ASP A 405GLY A 361PRO A 360HIS A 760 | None | 1.41A | 1tmxA-2hnhA:undetectable | 1tmxA-2hnhA:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2izv | SUPPRESSOR OFCYTOKINE SIGNALING 4 (Homo sapiens) |
PF00017(SH2)PF07525(SOCS_box) | 5 | LEU A 310GLY A 289TYR A 422ILE A 281HIS A 391 | None CL A1432 ( 4.0A)EDO A1431 ( 4.7A)None CL A1432 ( 3.8A) | 1.37A | 1tmxA-2izvA:undetectable | 1tmxA-2izvA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2puz | IMIDAZOLONEPROPIONASE (Agrobacteriumfabrum) |
PF01979(Amidohydro_1) | 5 | GLY A 212PRO A 211TYR A 204ILE A 205VAL A 242 | None | 1.29A | 1tmxA-2puzA:undetectable | 1tmxA-2puzA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q7x | UPF0052 PROTEINSP_1565 (Streptococcuspneumoniae) |
PF01933(UPF0052) | 5 | GLY A 192PRO A 191TYR A 220ILE A 224HIS A 239 | NoneNoneNone CL A 326 (-4.4A)None | 1.29A | 1tmxA-2q7xA:undetectable | 1tmxA-2q7xA:24.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] SMALL CHAIN (Azospirillumbrasilense) |
PF07992(Pyr_redox_2)PF14691(Fer4_20) | 5 | GLY G 192PRO G 191TYR G 32ILE G 97ARG G 96 | NoneNoneNoneFAD G 484 (-3.5A)None | 1.38A | 1tmxA-2vdcG:undetectable | 1tmxA-2vdcG:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vk9 | ALPHA-TOXIN (Clostridiumnovyi) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 5 | LEU A 139ASP A 202GLY A 106ILE A 205VAL A 201 | None | 1.45A | 1tmxA-2vk9A:undetectable | 1tmxA-2vk9A:17.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xsr | CATECHOL 1,2DIOXYGENASE (Acinetobacterradioresistens) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 7 | GLY A 103PRO A 104TYR A 161TYR A 195ARG A 216HIS A 219HIS A 221 | NoneNone FE A1307 (-4.3A)None FE A1307 ( 4.7A) FE A1307 (-3.3A) FE A1307 (-3.2A) | 0.59A | 1tmxA-2xsrA:27.7 | 1tmxA-2xsrA:30.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xsr | CATECHOL 1,2DIOXYGENASE (Acinetobacterradioresistens) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | LEU A 69GLY A 103ARG A 216HIS A 219HIS A 221 | NoneNone FE A1307 ( 4.7A) FE A1307 (-3.3A) FE A1307 (-3.2A) | 0.99A | 1tmxA-2xsrA:27.7 | 1tmxA-2xsrA:30.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwc | METALLOCARBOXYPEPTIDASE (Trypanosomacruzi) |
PF02074(Peptidase_M32) | 5 | LEU A 431GLY A 297ILE A 464HIS A 295HIS A 269 | NoneNoneNoneNone CO A 999 (-3.5A) | 1.48A | 1tmxA-3dwcA:undetectable | 1tmxA-3dwcA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3euf | URIDINEPHOSPHORYLASE 1 (Homo sapiens) |
PF01048(PNP_UDP_1) | 5 | LEU A 307GLY A 101PRO A 102ILE A 303VAL A 72 | None | 1.12A | 1tmxA-3eufA:undetectable | 1tmxA-3eufA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gxk | GOOSE-TYPE LYSOZYME1 (Gadus morhua) |
PF01464(SLT) | 5 | ASP A 118GLY A 122TYR A 151ILE A 117VAL A 55 | None | 1.47A | 1tmxA-3gxkA:undetectable | 1tmxA-3gxkA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hv0 | TRYPTOPHANYL-TRNASYNTHETASE (Cryptosporidiumparvum) |
PF00579(tRNA-synt_1b) | 5 | LEU A 326GLY A 282PRO A 283HIS A 289HIS A 292 | NoneTRP A 1 (-3.7A)NoneNoneNone | 1.46A | 1tmxA-3hv0A:undetectable | 1tmxA-3hv0A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4y | CATECHOL1,2-DIOXYGENASE (Rhodococcusopacus) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 6 | GLY A 104PRO A 105TYR A 162ARG A 217HIS A 220HIS A 222 | 35C A 1 (-3.0A)35C A 1 (-4.7A)35C A 1 ( 4.2A)35C A 1 (-3.9A) FE A 281 ( 3.4A) FE A 281 ( 3.3A) | 0.41A | 1tmxA-3i4yA:27.3 | 1tmxA-3i4yA:29.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4y | CATECHOL1,2-DIOXYGENASE (Rhodococcusopacus) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | LEU A 77GLY A 104ARG A 217HIS A 220HIS A 222 | 35C A 1 (-3.7A)35C A 1 (-3.0A)35C A 1 (-3.9A) FE A 281 ( 3.4A) FE A 281 ( 3.3A) | 0.98A | 1tmxA-3i4yA:27.3 | 1tmxA-3i4yA:29.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jd8 | NIEMANN-PICK C1PROTEIN (Homo sapiens) |
PF02460(Patched)PF12349(Sterol-sensing)PF16414(NPC1_N) | 5 | LEU A 547GLY A 432PRO A 434HIS A 510HIS A 418 | None | 1.33A | 1tmxA-3jd8A:undetectable | 1tmxA-3jd8A:12.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n9t | PNPC (Pseudomonasputida) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 10 | ASP A 80GLY A 106PRO A 107TYR A 160TYR A 194ILE A 196ARG A 215HIS A 218HIS A 220VAL A 248 | FLC A 293 (-3.6A)FLC A 293 ( 4.3A)FLC A 293 (-3.5A) FE A 292 ( 4.3A)FLC A 293 ( 4.0A)FLC A 293 (-4.1A)FLC A 293 (-4.3A) FE A 292 ( 3.2A) FE A 292 ( 3.1A)FLC A 293 (-4.7A) | 0.49A | 1tmxA-3n9tA:33.0 | 1tmxA-3n9tA:44.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n9t | PNPC (Pseudomonasputida) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 8 | ASP A 80GLY A 106PRO A 107TYR A 194ILE A 196ARG A 215HIS A 218HIS A 234 | FLC A 293 (-3.6A)FLC A 293 ( 4.3A)FLC A 293 (-3.5A)FLC A 293 ( 4.0A)FLC A 293 (-4.1A)FLC A 293 (-4.3A) FE A 292 ( 3.2A)None | 1.30A | 1tmxA-3n9tA:33.0 | 1tmxA-3n9tA:44.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n9t | PNPC (Pseudomonasputida) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 6 | LEU A 77ASP A 80TYR A 160ILE A 196HIS A 218VAL A 248 | FLC A 293 (-4.4A)FLC A 293 (-3.6A) FE A 292 ( 4.3A)FLC A 293 (-4.1A) FE A 292 ( 3.2A)FLC A 293 (-4.7A) | 1.47A | 1tmxA-3n9tA:33.0 | 1tmxA-3n9tA:44.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n9t | PNPC (Pseudomonasputida) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 9 | LEU A 77ASP A 80TYR A 160TYR A 194ILE A 196ARG A 215HIS A 218HIS A 220VAL A 248 | FLC A 293 (-4.4A)FLC A 293 (-3.6A) FE A 292 ( 4.3A)FLC A 293 ( 4.0A)FLC A 293 (-4.1A)FLC A 293 (-4.3A) FE A 292 ( 3.2A) FE A 292 ( 3.1A)FLC A 293 (-4.7A) | 0.52A | 1tmxA-3n9tA:33.0 | 1tmxA-3n9tA:44.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n9t | PNPC (Pseudomonasputida) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 7 | LEU A 77ASP A 80TYR A 194ILE A 196ARG A 215HIS A 218HIS A 234 | FLC A 293 (-4.4A)FLC A 293 (-3.6A)FLC A 293 ( 4.0A)FLC A 293 (-4.1A)FLC A 293 (-4.3A) FE A 292 ( 3.2A)None | 1.39A | 1tmxA-3n9tA:33.0 | 1tmxA-3n9tA:44.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8c | WISKOTT-ALDRICHSYNDROME PROTEINFAMILY MEMBER 1PROBABLE PROTEINBRICK1ABL INTERACTOR 2 (Homo sapiens;Homo sapiens;Homo sapiens) |
PF02205(WH2)no annotationPF07815(Abi_HHR) | 5 | LEU D 76TYR E 63ILE E 64ARG E 67VAL F 97 | None | 1.32A | 1tmxA-3p8cD:undetectable | 1tmxA-3p8cD:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s0m | OXALATEDECARBOXYLASE OXDC (Bacillussubtilis) |
PF00190(Cupin_1) | 5 | LEU A 329ARG A 270HIS A 273HIS A 319VAL A 262 | NoneNone MN A 501 (-3.5A) MN A 501 (-3.4A)None | 1.41A | 1tmxA-3s0mA:undetectable | 1tmxA-3s0mA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ssz | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME,N-TERMINAL DOMAINPROTEIN (Rhodobacteraceaebacterium KLH11) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 143ASP A 142GLY A 317TYR A 311ILE A 319 | None | 1.45A | 1tmxA-3sszA:undetectable | 1tmxA-3sszA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3th1 | CHLOROCATECHOL1,2-DIOXYGENASE (Pseudomonasputida) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 8 | LEU A 48ASP A 51GLY A 75PRO A 76TYR A 130TYR A 164HIS A 188HIS A 190 | DTD A 301 ( 4.8A)DTD A 301 (-4.1A)DTD A 301 (-3.5A)DTD A 301 (-4.5A) FE A 300 (-3.9A)DTD A 301 ( 3.9A) FE A 300 (-3.5A) FE A 300 (-3.3A) | 1.02A | 1tmxA-3th1A:26.8 | 1tmxA-3th1A:28.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3th1 | CHLOROCATECHOL1,2-DIOXYGENASE (Pseudomonasputida) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 9 | LEU A 48GLY A 75PRO A 76TYR A 130TYR A 164ILE A 166ARG A 185HIS A 188HIS A 190 | DTD A 301 ( 4.8A)DTD A 301 (-3.5A)DTD A 301 (-4.5A) FE A 300 (-3.9A)DTD A 301 ( 3.9A)DTD A 301 ( 4.5A)DTD A 301 (-4.2A) FE A 300 (-3.5A) FE A 300 (-3.3A) | 0.78A | 1tmxA-3th1A:26.8 | 1tmxA-3th1A:28.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3th1 | CHLOROCATECHOL1,2-DIOXYGENASE (Pseudomonasputida) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 6 | LEU A 48PRO A 76TYR A 130ILE A 166ARG A 185HIS A 188 | DTD A 301 ( 4.8A)DTD A 301 (-4.5A) FE A 300 (-3.9A)DTD A 301 ( 4.5A)DTD A 301 (-4.2A) FE A 300 (-3.5A) | 1.37A | 1tmxA-3th1A:26.8 | 1tmxA-3th1A:28.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u9r | METHYLCROTONYL-COACARBOXYLASE,BETA-SUBUNIT (Pseudomonasaeruginosa) |
PF01039(Carboxyl_trans) | 5 | ASP B 137GLY B 66ARG B 84HIS B 64VAL B 120 | None | 1.41A | 1tmxA-3u9rB:undetectable | 1tmxA-3u9rB:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vte | TETRAHYDROCANNABINOLIC ACID SYNTHASE (Cannabis sativa) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | GLY A 173PRO A 172ILE A 246HIS A 184VAL A 158 | NoneNoneNoneFAD A 607 (-3.8A)None | 1.48A | 1tmxA-3vteA:undetectable | 1tmxA-3vteA:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f52 | CULLIN-1 (Homo sapiens) |
PF00888(Cullin) | 5 | LEU A 540ASP A 510TYR A 570HIS A 574VAL A 513 | None | 1.35A | 1tmxA-4f52A:undetectable | 1tmxA-4f52A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ilt | INTRADIOLRING-CLEAVAGEDIOXYGENASE (Streptomycessp. SirexAA-E) |
PF00775(Dioxygenase_C) | 6 | GLY A 85PRO A 86TYR A 138ARG A 170HIS A 173HIS A 175 | NoneNone FE A 301 (-3.9A) FE A 301 ( 4.8A) FE A 301 (-3.1A) FE A 301 (-3.2A) | 0.53A | 1tmxA-4iltA:19.1 | 1tmxA-4iltA:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ilv | INTRADIOLRING-CLEAVAGEDIOXYGENASE (Streptomycessp. SirexAA-E) |
PF00775(Dioxygenase_C) | 7 | GLY A 85PRO A 86TYR A 138TYR A 167ARG A 170HIS A 173HIS A 175 | EDO A 302 ( 4.2A)EDO A 302 (-4.4A) FE A 301 ( 4.2A) FE A 301 ( 4.5A)EDO A 302 (-3.8A) FE A 301 ( 3.3A) FE A 301 ( 3.4A) | 0.36A | 1tmxA-4ilvA:19.0 | 1tmxA-4ilvA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jkm | BETA-GLUCURONIDASE (Clostridiumperfringens) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 5 | LEU A 361GLY A 358TYR A 423ILE A 381HIS A 387 | None | 1.36A | 1tmxA-4jkmA:undetectable | 1tmxA-4jkmA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4myw | ENVELOPEGLYCOPROTEIN D (Humanalphaherpesvirus2) |
PF01537(Herpes_glycop_D) | 5 | ASP A 30PRO A 225TYR A 115ARG A 130VAL A 34 | None | 1.31A | 1tmxA-4mywA:undetectable | 1tmxA-4mywA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qdv | M7GPPPXDIPHOSPHATASE (Homo sapiens) |
PF05652(DcpS)PF11969(DcpS_C) | 5 | GLY A 289PRO A 288TYR A 217HIS A 279HIS A 268 | NoneNoneNonePO4 A 402 (-4.0A)PO4 A 402 ( 3.8A) | 1.46A | 1tmxA-4qdvA:undetectable | 1tmxA-4qdvA:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rkz | PUTATIVEUNCHARACTERIZEDPROTEIN TA1305 (Thermoplasmaacidophilum) |
no annotation | 5 | LEU A 242GLY A 20ILE A 241ARG A 204HIS A 32 | None | 1.39A | 1tmxA-4rkzA:undetectable | 1tmxA-4rkzA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dud | YBGJ (Escherichiacoli) |
PF02682(CT_C_D) | 5 | LEU B 191GLY B 171TYR B 125ILE B 90HIS B 120 | None | 1.40A | 1tmxA-5dudB:undetectable | 1tmxA-5dudB:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hns | NIEMANN-PICK C1PROTEIN (Homo sapiens) |
no annotation | 5 | LEU A 547GLY A 432PRO A 434HIS A 510HIS A 418 | None | 1.39A | 1tmxA-5hnsA:undetectable | 1tmxA-5hnsA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mdh | MALATE DEHYDROGENASE (Sus scrofa) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | LEU A 170GLY A 207TYR A 209ILE A 166VAL A 177 | None | 1.47A | 1tmxA-5mdhA:undetectable | 1tmxA-5mdhA:22.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5td3 | CATECHOL1,2-DIOXYGENASE (Burkholderiavietnamiensis) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 6 | GLY A 118PRO A 119TYR A 175ARG A 232HIS A 235HIS A 237 | NoneNone ZN A 401 (-4.2A) ZN A 401 ( 4.7A) ZN A 401 (-3.2A) ZN A 401 (-3.1A) | 0.53A | 1tmxA-5td3A:27.8 | 1tmxA-5td3A:30.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5td3 | CATECHOL1,2-DIOXYGENASE (Burkholderiavietnamiensis) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 6 | LEU A 84GLY A 118TYR A 175ARG A 232HIS A 235HIS A 237 | EDO A 403 ( 4.6A)None ZN A 401 (-4.2A) ZN A 401 ( 4.7A) ZN A 401 (-3.2A) ZN A 401 (-3.1A) | 0.87A | 1tmxA-5td3A:27.8 | 1tmxA-5td3A:30.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5umh | CATECHOL1,2-DIOXYGENASE (Burkholderiamultivorans) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 7 | GLY A 107PRO A 108TYR A 164TYR A 200ARG A 221HIS A 224HIS A 226 | EDO A 402 (-3.6A)EDO A 402 (-4.4A) ZN A 401 ( 4.2A) ZN A 401 ( 4.7A)EDO A 402 (-3.4A) ZN A 401 ( 3.3A) ZN A 401 ( 3.2A) | 0.39A | 1tmxA-5umhA:27.5 | 1tmxA-5umhA:27.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5umh | CATECHOL1,2-DIOXYGENASE (Burkholderiamultivorans) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | LEU A 73GLY A 107ARG A 221HIS A 224HIS A 226 | NoneEDO A 402 (-3.6A)EDO A 402 (-3.4A) ZN A 401 ( 3.3A) ZN A 401 ( 3.2A) | 0.93A | 1tmxA-5umhA:27.5 | 1tmxA-5umhA:27.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vg2 | INTRADIOLRING-CLEAVAGEDIOXYGENASE (Tetranychusurticae) |
no annotation | 7 | GLY U 65PRO U 66TYR U 118TYR U 163ARG U 166HIS U 169HIS U 171 | NoneNone FE U 301 (-4.3A) FE U 301 (-4.8A) FE U 301 ( 4.9A) FE U 301 (-3.5A) FE U 301 (-3.3A) | 0.40A | 1tmxA-5vg2U:16.6 | 1tmxA-5vg2U:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x9r | CITRATE-SODIUMSYMPORTER (Klebsiellapneumoniae) |
PF03390(2HCT) | 5 | LEU A 408ASP A 407GLY A 403ILE A 121HIS A 299 | NoneNoneFLC A 501 ( 3.8A)NoneNone | 1.19A | 1tmxA-5x9rA:undetectable | 1tmxA-5x9rA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g72 | NADH DEHYDROGENASE[UBIQUINONE]FLAVOPROTEIN 2,MITOCHONDRIALNADH DEHYDROGENASE[UBIQUINONE]FLAVOPROTEIN 3,MITOCHONDRIAL (Mus musculus;Mus musculus) |
no annotationno annotation | 5 | GLY E 185PRO E 186TYR s 32HIS s 37HIS s 38 | None | 1.09A | 1tmxA-6g72E:undetectable | 1tmxA-6g72E:undetectable |