SIMILAR PATTERNS OF AMINO ACIDS FOR 1TLM_A_MILA128_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpo PROTEIN (CLATHRIN)

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link)
PF13838
(Clathrin_H_link) 		3 LEU A 466
LEU A 463
SER A 460
 None
 0.66A 1tlmA-1bpoA:
0.1		 1tlmA-1bpoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf5 PROTEIN
(BETA-MOMORCHARIN)

(Momordica
charantia) 		PF00161
(RIP) 		3 LEU A 238
LEU A  36
SER A  28
 None
 0.65A 1tlmA-1cf5A:
0.0		 1tlmA-1cf5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		3 LEU A 270
LEU A  64
SER A   3
 None
 0.63A 1tlmA-1drtA:
0.0		 1tlmA-1drtA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqw CU,ZN SUPEROXIDE
DISMUTASE

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		3 LEU A  98
LEU A  28
SER A  21
 None
 0.59A 1tlmA-1eqwA:
0.0		 1tlmA-1eqwA:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		3 LEU A  17
LEU A 110
SER A 117
 None
 0.60A 1tlmA-1gkeA:
22.3		 1tlmA-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		3 LEU A  35
LEU A  66
SER A  88
 None
 0.69A 1tlmA-1h1yA:
0.0		 1tlmA-1h1yA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		3 LEU A 275
LEU A 270
SER A 198
 None
 0.56A 1tlmA-1jy1A:
0.0		 1tlmA-1jy1A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 LEU A 490
LEU A 487
SER A 484
 None
 0.67A 1tlmA-1knrA:
0.0		 1tlmA-1knrA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 LEU A 108
LEU A  49
SER A  36
 None
 0.51A 1tlmA-1kwmA:
0.0		 1tlmA-1kwmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		3 LEU A 320
LEU A 384
SER A 387
 None
 0.58A 1tlmA-1l0qA:
undetectable		 1tlmA-1l0qA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		3 LEU A 415
LEU A 411
SER A 410
 None
 0.65A 1tlmA-1mb9A:
undetectable		 1tlmA-1mb9A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ngn METHYL-CPG BINDING
PROTEIN MBD4

(Mus musculus) 		PF00730
(HhH-GPD) 		3 LEU A 551
LEU A 553
SER A 554
 None
 0.41A 1tlmA-1ngnA:
undetectable		 1tlmA-1ngnA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or7 RNA POLYMERASE
SIGMA-E FACTOR

(Escherichia
coli) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2) 		3 LEU A 142
LEU A 138
SER A 137
 None
 0.57A 1tlmA-1or7A:
undetectable		 1tlmA-1or7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgs PEPTIDE-N(4)-(N-ACET
YL-BETA-D-GLUCOSAMIN
YL)ASPARAGINE
AMIDASE F

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		3 LEU A 264
LEU A 268
SER A 271
 None
 0.67A 1tlmA-1pgsA:
undetectable		 1tlmA-1pgsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		3 LEU A  11
LEU A   6
SER A 199
 None
None
EDO  A 313 ( 4.3A)
 0.67A 1tlmA-1pyfA:
undetectable		 1tlmA-1pyfA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51

(Pyrococcus
furiosus) 		PF08423
(Rad51)
PF14520
(HHH_5) 		3 LEU A 123
LEU A 120
SER A 117
 None
 0.67A 1tlmA-1pznA:
undetectable		 1tlmA-1pznA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		3 LEU A 405
LEU A 402
SER A 399
 None
 0.68A 1tlmA-1q15A:
undetectable		 1tlmA-1q15A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
ALPHA-SUBUNIT

(Pseudomonas
putida) 		PF00676
(E1_dh)
PF12573
(OxoDH_E1alpha_N) 		3 LEU A 237
LEU A 301
SER A 271
 None
 0.46A 1tlmA-1qs0A:
undetectable		 1tlmA-1qs0A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfn CONSERVED
HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF05899
(Cupin_3) 		3 LEU A1190
LEU A1236
SER A1168
 None
 0.32A 1tlmA-1sfnA:
undetectable		 1tlmA-1sfnA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdf THIOREDOXIN
REDUCTASE

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		3 LEU A 119
LEU A 121
SER A 123
 NAP  A 481 (-3.9A)
None
None
 0.57A 1tlmA-1tdfA:
undetectable		 1tlmA-1tdfA:
17.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		3 LEU A  17
LEU A 110
SER A 117
 None
 0.49A 1tlmA-1tfpA:
18.8		 1tlmA-1tfpA:
74.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us7 HSP90 CO-CHAPERONE
CDC37

(Homo sapiens) 		PF08564
(CDC37_C)
PF08565
(CDC37_M) 		3 LEU B 305
LEU B 301
SER B 300
 None
 0.68A 1tlmA-1us7B:
undetectable		 1tlmA-1us7B:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5j KIAA1355 PROTEIN

(Homo sapiens) 		PF00041
(fn3) 		3 LEU A  42
LEU A  80
SER A  92
 None
 0.67A 1tlmA-1v5jA:
undetectable		 1tlmA-1v5jA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgv KIAA1068 PROTEIN

(Homo sapiens) 		PF04969
(CS) 		3 LEU A  31
LEU A  97
SER A  83
 None
 0.65A 1tlmA-1wgvA:
undetectable		 1tlmA-1wgvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Mus musculus) 		no annotation 3 LEU A  91
LEU A  94
SER A  97
 None
 0.56A 1tlmA-1wwlA:
undetectable		 1tlmA-1wwlA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		3 LEU A 231
LEU A 228
SER A 225
 None
 0.67A 1tlmA-1xzqA:
undetectable		 1tlmA-1xzqA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ya5 TELETHONIN

(Homo sapiens) 		PF09470
(Telethonin) 		3 LEU T  60
LEU T  30
SER T   4
 None
 0.57A 1tlmA-1ya5T:
undetectable		 1tlmA-1ya5T:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		3 LEU A 108
LEU A  49
SER A  36
 None
 0.68A 1tlmA-1zliA:
undetectable		 1tlmA-1zliA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ab4 TRNA PSEUDOURIDINE
SYNTHASE B

(Thermotoga
maritima) 		PF01472
(PUA)
PF01509
(TruB_N)
PF16198
(TruB_C_2) 		3 LEU A 130
LEU A 127
SER A 118
 None
 0.60A 1tlmA-2ab4A:
undetectable		 1tlmA-2ab4A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e21 TRNA(ILE)-LYSIDINE
SYNTHASE

(Aquifex
aeolicus) 		PF01171
(ATP_bind_3) 		3 LEU A 152
LEU A 155
SER A 142
 None
 0.68A 1tlmA-2e21A:
undetectable		 1tlmA-2e21A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8v TELETHONIN

(Homo sapiens) 		PF09470
(Telethonin) 		3 LEU T  60
LEU T  30
SER T   4
 None
 0.56A 1tlmA-2f8vT:
undetectable		 1tlmA-2f8vT:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjr REPRESSOR PROTEIN CI

(Escherichia
virus 186) 		PF07022
(Phage_CI_repr)
PF16452
(Phage_CI_C) 		3 LEU A  98
LEU A  93
SER A 123
 None
 0.69A 1tlmA-2fjrA:
undetectable		 1tlmA-2fjrA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h27 RNA POLYMERASE SIGMA
E FACTOR

(Escherichia
coli) 		PF08281
(Sigma70_r4_2) 		3 LEU A 142
LEU A 138
SER A 137
 None
 0.65A 1tlmA-2h27A:
undetectable		 1tlmA-2h27A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF10672
(Methyltrans_SAM) 		3 LEU A  16
LEU A 282
SER A 301
 ACY  A1010 (-4.9A)
None
None
 0.26A 1tlmA-2igtA:
undetectable		 1tlmA-2igtA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		3 LEU A  92
LEU A 245
SER A 206
 None
None
AKG  A 700 ( 4.1A)
 0.61A 1tlmA-2iuwA:
undetectable		 1tlmA-2iuwA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		3 LEU A 426
LEU A 440
SER A 443
 None
 0.66A 1tlmA-2oajA:
undetectable		 1tlmA-2oajA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato bushy
stunt virus) 		PF00729
(Viral_coat) 		3 LEU A 239
LEU A 132
SER A 131
 None
 0.68A 1tlmA-2tbvA:
undetectable		 1tlmA-2tbvA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		3 LEU A  85
LEU A  82
SER A  79
 None
 0.67A 1tlmA-2x9pA:
undetectable		 1tlmA-2x9pA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		3 LEU A 616
LEU A 613
SER A 610
 None
 0.64A 1tlmA-2xa7A:
undetectable		 1tlmA-2xa7A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A

(Brevibacillus
brevis) 		PF00668
(Condensation) 		3 LEU A 140
LEU A 131
SER A  95
 None
 0.68A 1tlmA-2xhgA:
undetectable		 1tlmA-2xhgA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 LEU A 567
LEU A 570
SER A 573
 None
 0.68A 1tlmA-2y3aA:
undetectable		 1tlmA-2y3aA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylf PROTEIN SPIRE
HOMOLOG 1

(Homo sapiens) 		PF16474
(KIND) 		3 LEU A 156
LEU A 153
SER A 150
 None
 0.64A 1tlmA-2ylfA:
undetectable		 1tlmA-2ylfA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynp COATOMER SUBUNIT
BETA'

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		3 LEU A 501
LEU A 482
SER A 477
 None
 0.64A 1tlmA-2ynpA:
undetectable		 1tlmA-2ynpA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE

(Thermotoga
maritima) 		PF04029
(2-ph_phosp) 		3 LEU A 209
LEU A 115
SER A 113
 None
 0.48A 1tlmA-2yyvA:
undetectable		 1tlmA-2yyvA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zl3 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Helicobacter
pylori) 		PF00574
(CLP_protease) 		3 LEU A 191
LEU A 116
SER A 119
 None
 0.65A 1tlmA-2zl3A:
undetectable		 1tlmA-2zl3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		3 LEU A 105
LEU A  89
SER A  60
 None
BEN  A   8 ( 4.6A)
None
 0.66A 1tlmA-3beuA:
undetectable		 1tlmA-3beuA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg0 NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		3 LEU B 399
LEU B 402
SER B 405
 None
 0.67A 1tlmA-3bg0B:
undetectable		 1tlmA-3bg0B:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 LEU A1037
LEU A1033
SER A1032
 None
 0.65A 1tlmA-3bg9A:
undetectable		 1tlmA-3bg9A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		3 LEU A 427
LEU A 380
SER A 377
 None
 0.68A 1tlmA-3bh1A:
undetectable		 1tlmA-3bh1A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfy PUTATIVE LUXO
REPRESSOR PROTEIN

(Vibrio
parahaemolyticus) 		PF00072
(Response_reg) 		3 LEU A  17
LEU A  14
SER A  11
 None
 0.61A 1tlmA-3cfyA:
undetectable		 1tlmA-3cfyA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg1 UPF0100 PROTEIN
PF0080

(Pyrococcus
furiosus) 		PF13531
(SBP_bac_11) 		3 LEU A 221
LEU A 224
SER A 229
 None
 0.69A 1tlmA-3cg1A:
undetectable		 1tlmA-3cg1A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		3 LEU A 216
LEU A 219
SER A 224
 None
 0.68A 1tlmA-3cg3A:
undetectable		 1tlmA-3cg3A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		3 LEU B 101
LEU B 104
SER B 109
 None
 0.66A 1tlmA-3draB:
undetectable		 1tlmA-3draB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8u TAPASIN

(Homo sapiens) 		PF07654
(C1-set) 		3 LEU B 115
LEU B 142
SER B 161
 None
None
NAG  B1233 ( 4.6A)
 0.44A 1tlmA-3f8uB:
undetectable		 1tlmA-3f8uB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472

(Listeria
monocytogenes) 		PF04816
(TrmK) 		3 LEU A  39
LEU A  16
SER A  13
 None
 0.55A 1tlmA-3gnlA:
undetectable		 1tlmA-3gnlA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		3 LEU A 383
LEU A 450
SER A 330
 None
 0.57A 1tlmA-3hvdA:
undetectable		 1tlmA-3hvdA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijt PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		no annotation 3 LEU A  74
LEU A  83
SER A 103
 None
 0.64A 1tlmA-3ijtA:
undetectable		 1tlmA-3ijtA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iwu 5-HYDROXYISOURATE
HYDROLASE

(Danio rerio) 		PF00576
(Transthyretin) 		3 LEU A  14
LEU A 107
SER A 114
 None
 0.58A 1tlmA-3iwuA:
18.9		 1tlmA-3iwuA:
32.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0o RIBOSOMAL PROTEIN
S15

(Oryctolagus
cuniculus) 		PF00203
(Ribosomal_S19) 		3 LEU S  41
LEU S  38
SER S  35
 None
 0.67A 1tlmA-3j0oS:
undetectable		 1tlmA-3j0oS:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 LEU X 762
LEU X 765
SER X 769
 None
 0.60A 1tlmA-3jb9X:
undetectable		 1tlmA-3jb9X:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsk CYPBP37 PROTEIN

(Neurospora
crassa) 		PF01946
(Thi4) 		3 LEU A  43
LEU A  40
SER A  37
 None
 0.60A 1tlmA-3jskA:
undetectable		 1tlmA-3jskA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kby PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10804
(DUF2538) 		3 LEU A  94
LEU A  90
SER A  89
 None
 0.58A 1tlmA-3kbyA:
undetectable		 1tlmA-3kbyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kby PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10804
(DUF2538) 		3 LEU A  97
LEU A  94
SER A  91
 None
 0.65A 1tlmA-3kbyA:
undetectable		 1tlmA-3kbyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnb N-ACETYLTRANSFERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00797
(Acetyltransf_2) 		3 LEU A  29
LEU A 132
SER A 144
 None
FMT  A1002 ( 4.6A)
FMT  A1002 (-4.4A)
 0.52A 1tlmA-3lnbA:
undetectable		 1tlmA-3lnbA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m33 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		no annotation 3 LEU A  82
LEU A  79
SER A  76
 None
 0.62A 1tlmA-3m33A:
undetectable		 1tlmA-3m33A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mud DNA REPAIR PROTEIN
XRCC4,TROPOMYOSIN
ALPHA-1 CHAIN

(Gallus gallus;
Homo sapiens) 		PF06632
(XRCC4) 		3 LEU A  36
LEU A  20
SER A   6
 None
 0.61A 1tlmA-3mudA:
undetectable		 1tlmA-3mudA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvg RIBOSOME
INACTIVATING TYPE 1
PROTEIN

(Iris x
hollandica) 		PF00161
(RIP) 		3 LEU A 247
LEU A  38
SER A  29
 None
None
SO4  A 276 ( 4.8A)
 0.63A 1tlmA-3mvgA:
undetectable		 1tlmA-3mvgA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxp PRETHROMBIN-1

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		3 LEU A 505
LEU A 453
SER A 445
 None
 0.64A 1tlmA-3nxpA:
undetectable		 1tlmA-3nxpA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9z UROPORPHYRINOGEN III
COSYNTHASE (HEMD)

(Helicobacter
pylori) 		PF02602
(HEM4) 		3 LEU A  49
LEU A  53
SER A  56
 None
 0.69A 1tlmA-3p9zA:
undetectable		 1tlmA-3p9zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		3 LEU B 226
LEU B  31
SER B  34
 None
 0.51A 1tlmA-3pdiB:
undetectable		 1tlmA-3pdiB:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 3 LEU A 351
LEU A 348
SER A 345
 None
 0.64A 1tlmA-3phfA:
undetectable		 1tlmA-3phfA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		3 LEU A 209
LEU A 212
SER A 215
 None
 0.63A 1tlmA-3pieA:
undetectable		 1tlmA-3pieA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pra FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Methanocaldococcus
jannaschii) 		PF00254
(FKBP_C) 		3 LEU A  90
LEU A 127
SER A 120
 None
 0.55A 1tlmA-3praA:
undetectable		 1tlmA-3praA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 LEU B 280
LEU B 264
SER B 317
 None
 0.59A 1tlmA-3prxB:
undetectable		 1tlmA-3prxB:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm1 CINNAMOYL ESTERASE

(Lactobacillus
johnsonii) 		PF12146
(Hydrolase_4) 		3 LEU A   6
LEU A  13
SER A  68
 None
 0.53A 1tlmA-3qm1A:
undetectable		 1tlmA-3qm1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7g PROTEIN SPIRE
HOMOLOG 1

(Homo sapiens) 		PF16474
(KIND) 		3 LEU A 156
LEU A 153
SER A 150
 None
 0.64A 1tlmA-3r7gA:
undetectable		 1tlmA-3r7gA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl3 METALLOPHOSPHOESTERA
SE MPPED2

(Rattus
norvegicus) 		PF00149
(Metallophos) 		3 LEU A  90
LEU A  92
SER A  94
 None
 0.56A 1tlmA-3rl3A:
undetectable		 1tlmA-3rl3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		3 LEU A 908
LEU A 905
SER A 902
 None
 0.62A 1tlmA-3s51A:
undetectable		 1tlmA-3s51A:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Mus musculus) 		PF04389
(Peptidase_M28) 		3 LEU A 138
LEU A 196
SER A 126
 None
 0.65A 1tlmA-3si1A:
undetectable		 1tlmA-3si1A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sma FRBF

(Streptomyces
rubellomurinus) 		PF02522
(Antibiotic_NAT) 		3 LEU A 180
LEU A 260
SER A 249
 None
 0.48A 1tlmA-3smaA:
undetectable		 1tlmA-3smaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6c PUTATIVE MAND FAMILY
DEHYDRATASE

(Pantoea
ananatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 113
LEU A 114
SER A 344
 None
 0.59A 1tlmA-3t6cA:
undetectable		 1tlmA-3t6cA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		3 LEU A 715
LEU A 741
SER A 461
 None
 0.58A 1tlmA-3tbkA:
undetectable		 1tlmA-3tbkA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thu MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Sphingomonas
sp. SKA58) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 109
LEU A 110
SER A 332
 None
 0.61A 1tlmA-3thuA:
undetectable		 1tlmA-3thuA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0i PROBABLE
FAD-BINDING,
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Brucella
abortus) 		PF12900
(Pyridox_ox_2) 		3 LEU A  67
LEU A  81
SER A 139
 None
EDO  A 146 ( 4.2A)
EDO  A 146 (-2.8A)
 0.60A 1tlmA-3u0iA:
undetectable		 1tlmA-3u0iA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcn MANNONATE
DEHYDRATASE

(Caulobacter
vibrioides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 109
LEU A 110
SER A 332
 None
 0.53A 1tlmA-3vcnA:
undetectable		 1tlmA-3vcnA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		3 LEU A 223
LEU A 219
SER A 218
 None
 0.62A 1tlmA-3wo8A:
undetectable		 1tlmA-3wo8A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp9 ICE-BINDING PROTEIN

(Colwellia sp.
SLW05) 		PF11999
(DUF3494) 		3 LEU A  76
LEU A  73
SER A  70
 None
 0.64A 1tlmA-3wp9A:
undetectable		 1tlmA-3wp9A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9

(Homo sapiens) 		PF07525
(SOCS_box)
PF12796
(Ank_2) 		3 LEU A 217
LEU A 214
SER A 211
 None
None
CL  A1297 (-3.5A)
 0.68A 1tlmA-3zkjA:
undetectable		 1tlmA-3zkjA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF02156
(Glyco_hydro_26)
PF16990
(CBM_35) 		3 LEU A 103
LEU A  58
SER A 130
 None
 0.55A 1tlmA-3zm8A:
undetectable		 1tlmA-3zm8A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zri CLPB PROTEIN

(Vibrio cholerae) 		PF02861
(Clp_N) 		3 LEU A 135
LEU A 132
SER A 129
 None
 0.67A 1tlmA-3zriA:
undetectable		 1tlmA-3zriA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9a PROBABLE EPOXIDE
HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		3 LEU A  15
LEU A  22
SER A  70
 None
 0.63A 1tlmA-4b9aA:
undetectable		 1tlmA-4b9aA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		3 LEU A 567
LEU A 570
SER A 573
 None
 0.64A 1tlmA-4bfrA:
2.7		 1tlmA-4bfrA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 LEU A 567
LEU A 460
SER A 728
 None
 0.59A 1tlmA-4cakA:
undetectable		 1tlmA-4cakA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccl 50S RIBOSOMAL
PROTEIN L16 ARGININE
HYDROXYLASE

(Escherichia
coli) 		PF08007
(Cupin_4) 		3 LEU A  81
LEU A  53
SER A  64
 None
 0.55A 1tlmA-4cclA:
undetectable		 1tlmA-4cclA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckt PIH1
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF08190
(PIH1) 		3 LEU A 141
LEU A 138
SER A 135
 None
 0.65A 1tlmA-4cktA:
undetectable		 1tlmA-4cktA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		3 LEU A  84
LEU A  85
SER A  89
 None
 0.69A 1tlmA-4effA:
undetectable		 1tlmA-4effA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exl PHOSPHATE-BINDING
PROTEIN PSTS 1

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		3 LEU A  44
LEU A  41
SER A  38
 None
 0.34A 1tlmA-4exlA:
undetectable		 1tlmA-4exlA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2f CATION-TRANSPORTING
ATPASE, E1-E2 FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13473
(Cupredoxin_1) 		3 LEU A  61
LEU A  54
SER A  85
 None
 0.60A 1tlmA-4f2fA:
undetectable		 1tlmA-4f2fA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		3 LEU A 427
LEU A 423
SER A 422
 None
 0.60A 1tlmA-4fimA:
undetectable		 1tlmA-4fimA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm2 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Plasmodium
falciparum) 		PF00574
(CLP_protease) 		3 LEU A 241
LEU A 165
SER A 168
 None
 0.62A 1tlmA-4gm2A:
undetectable		 1tlmA-4gm2A:
17.20