SIMILAR PATTERNS OF AMINO ACIDS FOR 1TKQ_A_DVAA8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egx VASODILATOR-STIMULAT
ED PHOSPHOPROTEIN

(Homo sapiens) 		PF00568
(WH1) 		4 VAL A  67
TRP A  82
TRP A  89
GLY A  69
 None
 1.38A 1tkqA-1egxA:
undetectable
1tkqB-1egxA:
undetectable		 1tkqA-1egxA:
5.71
1tkqB-1egxA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8k HYPOTHETICAL
PROTEIN, GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN

(Bacteroides
uniformis) 		PF16255
(Lipase_GDSL_lke) 		4 VAL A 211
TRP A  67
TRP A  68
GLY A 213
 None
 1.17A 1tkqA-4m8kA:
undetectable
1tkqB-4m8kA:
undetectable		 1tkqA-4m8kA:
3.07
1tkqB-4m8kA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 4 VAL B  75
TRP B  81
TRP B  80
GLY B 235
 None
 1.35A 1tkqA-6cxhB:
undetectable
1tkqB-6cxhB:
undetectable		 1tkqA-6cxhB:
undetectable
1tkqB-6cxhB:
undetectable