SIMILAR PATTERNS OF AMINO ACIDS FOR 1TKQ_A_DVAA6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1b PROTEIN (IRON
DEPENDENT REGULATOR)

(Mycobacterium
tuberculosis) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		3 ALA A  99
VAL A  97
TRP A  94
 None
 0.98A 1tkqA-1b1bA:
undetectable		 1tkqA-1b1bA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		3 ALA A 113
VAL A 153
TRP A 193
 None
 0.89A 1tkqA-1ehkA:
undetectable		 1tkqA-1ehkA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eom ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F3

(Elizabethkingia
meningoseptica) 		PF00704
(Glyco_hydro_18) 		3 ALA A 157
VAL A 191
TRP A 194
 SO4  A 702 ( 4.3A)
None
None
 0.79A 1tkqA-1eomA:
undetectable		 1tkqA-1eomA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE

(Thermococcus
profundus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 ALA A  77
VAL A 110
TRP A  74
 None
 0.69A 1tkqA-1euzA:
undetectable		 1tkqA-1euzA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gp1 GLUTATHIONE
PEROXIDASE

(Bos taurus) 		PF00255
(GSHPx) 		3 ALA A 123
VAL A 113
TRP A 148
 None
 1.00A 1tkqA-1gp1A:
undetectable		 1tkqA-1gp1A:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		3 ALA A   1
VAL A 370
TRP A 504
 None
 0.87A 1tkqA-1gzvA:
undetectable		 1tkqA-1gzvA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		3 ALA A 351
VAL A 175
TRP A 173
 None
 1.01A 1tkqA-1kehA:
undetectable		 1tkqA-1kehA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		3 ALA A 305
VAL A 407
TRP A 410
 None
 0.98A 1tkqA-1m2wA:
undetectable		 1tkqA-1m2wA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ma1 SUPEROXIDE DISMUTASE

(Methanothermobacter
thermautotrophicus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ALA A  90
VAL A 191
TRP A 188
 None
 1.02A 1tkqA-1ma1A:
undetectable		 1tkqA-1ma1A:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnv HYPOTHETICAL PROTEIN
HI1450

(Haemophilus
influenzae) 		PF04269
(DUF440) 		3 ALA A  70
VAL A  50
TRP A  73
 None
 1.01A 1tkqA-1nnvA:
undetectable		 1tkqA-1nnvA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqh HYPOTHETICAL PROTEIN
CG14615-PA

(Drosophila
melanogaster) 		PF08445
(FR47) 		3 ALA A 224
VAL A 187
TRP A 191
 None
 0.95A 1tkqA-1sqhA:
undetectable		 1tkqA-1sqhA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tza APAG PROTEIN

(Shewanella
oneidensis) 		PF04379
(DUF525) 		3 ALA A  66
VAL A  68
TRP A  51
 ALA  A  66 ( 0.0A)
VAL  A  68 ( 0.6A)
TRP  A  51 ( 0.5A)
 0.75A 1tkqA-1tzaA:
undetectable		 1tkqA-1tzaA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE
GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1;
Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		3 ALA C 182
VAL B   6
TRP B   4
 None
 0.99A 1tkqA-2advC:
undetectable		 1tkqA-2advC:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auw HYPOTHETICAL PROTEIN
NE0471

(Nitrosomonas
europaea) 		PF10387
(DUF2442) 		3 ALA A  85
VAL A  32
TRP A  80
 None
None
GOL  A1202 (-3.4A)
 0.93A 1tkqA-2auwA:
undetectable		 1tkqA-2auwA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2i AMMONIUM TRANSPORTER

(Archaeoglobus
fulgidus) 		PF00909
(Ammonium_transp) 		3 ALA A 303
VAL A 282
TRP A 311
 None
 0.94A 1tkqA-2b2iA:
undetectable		 1tkqA-2b2iA:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		3 ALA A 293
VAL A 475
TRP A 384
 None
 1.00A 1tkqA-2bs9A:
undetectable		 1tkqA-2bs9A:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8a GLUTATHIONE
PEROXIDASE 1

(Homo sapiens) 		PF00255
(GSHPx) 		3 ALA A 125
VAL A 115
TRP A 150
 None
 0.99A 1tkqA-2f8aA:
undetectable		 1tkqA-2f8aA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he3 GLUTATHIONE
PEROXIDASE 2

(Homo sapiens) 		PF00255
(GSHPx) 		3 ALA A 117
VAL A 107
TRP A 142
 None
 0.95A 1tkqA-2he3A:
undetectable		 1tkqA-2he3A:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi8 SULFATASE-MODIFYING
FACTOR 1

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		3 ALA X 358
VAL X 209
TRP X 188
 None
 0.80A 1tkqA-2hi8X:
undetectable		 1tkqA-2hi8X:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrt UNCHARACTERIZED
PROTEIN

(Rhodobacter
sphaeroides) 		PF06627
(DUF1153) 		3 ALA A  75
VAL A  73
TRP A  69
 None
 0.88A 1tkqA-2jrtA:
undetectable		 1tkqA-2jrtA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjh UBIQUITIN/ISG15-CONJ
UGATING ENZYME E2 L6

(Homo sapiens) 		PF00179
(UQ_con) 		3 ALA A  29
VAL A  31
TRP A  34
 None
 1.00A 1tkqA-2kjhA:
undetectable		 1tkqA-2kjhA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF08327
(AHSA1) 		3 ALA A  22
VAL A  24
TRP A  28
 None
 0.94A 1tkqA-2ldkA:
undetectable		 1tkqA-2ldkA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzy PROBABLE
FE(2+)-TRAFFICKING
PROTEIN

(Burkholderia
pseudomallei) 		PF04362
(Iron_traffic) 		3 ALA A   8
VAL A  34
TRP A  42
 None
 0.84A 1tkqA-2mzyA:
undetectable		 1tkqA-2mzyA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyz HYPOTHETICAL PROTEIN
GAMMAHV.M3

(Murid
gammaherpesvirus
4) 		PF09213
(M3) 		3 ALA A 206
VAL A  74
TRP A  76
 None
 0.70A 1tkqA-2nyzA:
undetectable		 1tkqA-2nyzA:
3.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oda HYPOTHETICAL PROTEIN
PSPTO_2114

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 3 ALA A   8
VAL A 109
TRP A 127
 None
 0.99A 1tkqA-2odaA:
undetectable		 1tkqA-2odaA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 ALA A 237
VAL A 242
TRP A 245
 None
 0.85A 1tkqA-2p3xA:
undetectable		 1tkqA-2p3xA:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 ALA A 197
VAL A 199
TRP A 136
 None
None
EDO  A 341 ( 3.8A)
 1.01A 1tkqA-2r3sA:
undetectable		 1tkqA-2r3sA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcf UNIDENTIFIED
CARBOXYSOME
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF03319
(EutN_CcmL) 		3 ALA A  38
VAL A  26
TRP A  28
 None
 0.88A 1tkqA-2rcfA:
undetectable		 1tkqA-2rcfA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rex RHO-RELATED
GTP-BINDING PROTEIN
RHO6

(Homo sapiens) 		PF00071
(Ras) 		3 ALA B  87
VAL B  17
TRP B  66
 None
 0.95A 1tkqA-2rexB:
undetectable		 1tkqA-2rexB:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		3 ALA A  90
VAL A  88
TRP A  69
 None
 1.01A 1tkqA-3ayxA:
undetectable		 1tkqA-3ayxA:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzb UNCHARACTERIZED
PROTEIN

(Cyanidioschyzon
merolae) 		PF10294
(Methyltransf_16) 		3 ALA A 170
VAL A 203
TRP A 260
 None
 0.97A 1tkqA-3bzbA:
undetectable		 1tkqA-3bzbA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4b ALGK

(Pseudomonas
fluorescens) 		no annotation 3 ALA A 301
VAL A 299
TRP A 298
 None
 0.97A 1tkqA-3e4bA:
undetectable		 1tkqA-3e4bA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j08 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		3 ALA A 720
VAL A 718
TRP A 678
 None
 0.95A 1tkqA-3j08A:
undetectable		 1tkqA-3j08A:
2.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		3 ALA A 720
VAL A 718
TRP A 678
 None
 0.99A 1tkqA-3j09A:
undetectable		 1tkqA-3j09A:
2.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jci CAPSID PROTEIN

(Porcine
circovirus 2) 		PF02443
(Circo_capsid) 		3 ALA A 122
VAL A 142
TRP A  67
 None
 0.99A 1tkqA-3jciA:
undetectable		 1tkqA-3jciA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jst PUTATIVE
PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE

(Brucella
melitensis) 		PF01329
(Pterin_4a) 		3 ALA A  65
VAL A  69
TRP A  62
 None
 0.95A 1tkqA-3jstA:
undetectable		 1tkqA-3jstA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		3 ALA A  83
VAL A  31
TRP A  21
 None
 0.91A 1tkqA-3mgaA:
undetectable		 1tkqA-3mgaA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pov ORF 37

(Human
gammaherpesvirus
8) 		PF01771
(Herpes_alk_exo) 		3 ALA A  33
VAL A 134
TRP A 135
 None
 0.99A 1tkqA-3povA:
undetectable		 1tkqA-3povA:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167

(Homo sapiens) 		PF07654
(C1-set) 		3 ALA A  88
VAL A  78
TRP A  65
 None
 0.82A 1tkqA-3pv6A:
undetectable		 1tkqA-3pv6A:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qld MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ALA A 353
VAL A 355
TRP A  44
 None
 0.85A 1tkqA-3qldA:
undetectable		 1tkqA-3qldA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0r PORCINE CIRCOVIRUS 2
(PCV2) CAPSID
PROTEIN

(Porcine
circovirus 2) 		PF02443
(Circo_capsid) 		3 ALA A 117
VAL A 137
TRP A  62
 None
 1.00A 1tkqA-3r0rA:
undetectable		 1tkqA-3r0rA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7k PROBABLE ACYL COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ALA A 334
VAL A 336
TRP A 326
 None
 0.92A 1tkqA-3r7kA:
undetectable		 1tkqA-3r7kA:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rft URONATE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		3 ALA A 159
VAL A 202
TRP A 204
 None
 0.99A 1tkqA-3rftA:
undetectable		 1tkqA-3rftA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		3 ALA A 292
VAL A 289
TRP A 308
 None
 0.91A 1tkqA-3tp9A:
undetectable		 1tkqA-3tp9A:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ure ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes) 		PF00089
(Trypsin) 		3 ALA A  55
VAL A  53
TRP A 105
 None
 1.02A 1tkqA-3ureA:
undetectable		 1tkqA-3ureA:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN

(Escherichia
coli) 		PF00374
(NiFeSe_Hases) 		3 ALA L  90
VAL L  88
TRP L  69
 None
 0.98A 1tkqA-3uscL:
undetectable		 1tkqA-3uscL:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9a ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		3 ALA A  55
VAL A  51
TRP A  58
 None
 0.86A 1tkqA-3v9aA:
undetectable		 1tkqA-3v9aA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 ALA A 199
VAL A 170
TRP A  40
 None
 1.00A 1tkqA-3vuoA:
undetectable		 1tkqA-3vuoA:
0.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 3 ALA A 214
VAL A 262
TRP A 369
 None
 0.93A 1tkqA-3w36A:
undetectable		 1tkqA-3w36A:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 ALA A 485
VAL A 483
TRP A 459
 None
 0.74A 1tkqA-3zz1A:
undetectable		 1tkqA-3zz1A:
2.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqs LAMININ SUBUNIT
BETA-1

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		3 ALA A  47
VAL A  99
TRP A 112
 None
 0.93A 1tkqA-4aqsA:
undetectable		 1tkqA-4aqsA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew5 CIGR PROTEIN

(Salmonella
enterica) 		no annotation 3 ALA A 119
VAL A 117
TRP A 133
 None
 0.82A 1tkqA-4ew5A:
undetectable		 1tkqA-4ew5A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		3 ALA A 420
VAL A 424
TRP A 427
 None
 0.88A 1tkqA-4fgmA:
undetectable		 1tkqA-4fgmA:
3.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 ALA A  19
VAL A 158
TRP A 156
 None
 0.98A 1tkqA-4fnqA:
undetectable		 1tkqA-4fnqA:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2d NADPH-DEPENDENT
DIFLAVIN
OXIDOREDUCTASE 1

(Homo sapiens) 		PF00258
(Flavodoxin_1) 		3 ALA A 140
VAL A 142
TRP A 145
 None
 0.94A 1tkqA-4h2dA:
undetectable		 1tkqA-4h2dA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz2 GLUTATHIONE
S-TRANSFERASE DOMAIN

(Xanthobacter
autotrophicus) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 ALA A 144
VAL A 181
TRP A 184
 None
 1.02A 1tkqA-4hz2A:
undetectable		 1tkqA-4hz2A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya) 		PF03576
(Peptidase_S58) 		3 ALA A 158
VAL A 114
TRP A 117
 None
 0.96A 1tkqA-4iheA:
undetectable		 1tkqA-4iheA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4juu EPIMERASE

(Xanthomonas
campestris) 		PF05544
(Pro_racemase) 		3 ALA A 283
VAL A 134
TRP A 159
 None
 0.69A 1tkqA-4juuA:
undetectable		 1tkqA-4juuA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf8 NUP188

(Thermothelomyces
thermophila) 		no annotation 3 ALA A1653
VAL A1643
TRP A1659
 None
 0.89A 1tkqA-4kf8A:
undetectable		 1tkqA-4kf8A:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmc RNA
POLYMERASE-BINDING
TRANSCRIPTION FACTOR
CARD

(Mycobacterium
tuberculosis) 		no annotation 3 ALA A 129
VAL A 108
TRP A 112
 None
 1.02A 1tkqA-4kmcA:
undetectable		 1tkqA-4kmcA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 ALA A 781
VAL A 785
TRP A 788
 None
 0.91A 1tkqA-4lglA:
undetectable		 1tkqA-4lglA:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4r EPHRIN TYPE-A
RECEPTOR 4

(Homo sapiens) 		PF00041
(fn3)
PF01404
(Ephrin_lbd) 		3 ALA A 445
VAL A 447
TRP A 461
 None
 0.90A 1tkqA-4m4rA:
undetectable		 1tkqA-4m4rA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maf ATP SULFURYLASE

(Glycine max) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 ALA A 287
VAL A 290
TRP A 294
 None
 0.79A 1tkqA-4mafA:
undetectable		 1tkqA-4mafA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ALA A2552
VAL A2637
TRP A2638
 None
 0.94A 1tkqA-4qyrA:
undetectable		 1tkqA-4qyrA:
1.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		3 ALA A  46
VAL A  44
TRP A  40
 None
 0.89A 1tkqA-4rncA:
undetectable		 1tkqA-4rncA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		3 ALA A 154
VAL A 110
TRP A 114
 78N  A1451 ( 3.7A)
None
None
 1.01A 1tkqA-4us4A:
undetectable		 1tkqA-4us4A:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		3 ALA A 183
VAL A 181
TRP A 178
 None
 0.60A 1tkqA-4w1wA:
undetectable		 1tkqA-4w1wA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca) 		PF04547
(Anoctamin) 		3 ALA A 444
VAL A 442
TRP A 521
 None
 0.99A 1tkqA-4wisA:
undetectable		 1tkqA-4wisA:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4l CELLOBIOSE
2-EPIMERASE

(Caldicellulosiruptor
saccharolyticus) 		PF07221
(GlcNAc_2-epim) 		3 ALA A 332
VAL A 314
TRP A 337
 None
 0.84A 1tkqA-4z4lA:
undetectable		 1tkqA-4z4lA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zow MULTIDRUG
TRANSPORTER MDFA

(Escherichia
coli) 		PF07690
(MFS_1) 		3 ALA A 178
VAL A  94
TRP A  91
 None
 0.99A 1tkqA-4zowA:
undetectable		 1tkqA-4zowA:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4

(Saccharomyces
cerevisiae) 		PF01793
(Glyco_transf_15) 		3 ALA A 385
VAL A 387
TRP A 382
 None
 0.98A 1tkqA-5a08A:
undetectable		 1tkqA-5a08A:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa) 		PF00022
(Actin) 		3 ALA J 121
VAL J  95
TRP J 387
 None
 1.02A 1tkqA-5afuJ:
undetectable		 1tkqA-5afuJ:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aws SH3-CONTAINING
GRB2-LIKE PROTEIN
3-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF10291
(muHD) 		3 ALA A 808
VAL A 806
TRP A 646
 None
 0.58A 1tkqA-5awsA:
undetectable		 1tkqA-5awsA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3g PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		3 ALA B 525
VAL B 388
TRP B 468
 None
 0.97A 1tkqA-5b3gB:
undetectable		 1tkqA-5b3gB:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		3 ALA B 525
VAL B 388
TRP B 468
 None
 1.02A 1tkqA-5b3hB:
undetectable		 1tkqA-5b3hB:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5q MEMBRANE THIOL
PROTEASE

(Chlamydia
trachomatis) 		PF02902
(Peptidase_C48) 		3 ALA B 165
VAL B 163
TRP B 348
 None
 0.87A 1tkqA-5b5qB:
undetectable		 1tkqA-5b5qB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4r PRECORRIN-6A
REDUCTASE

(Rhodobacter
capsulatus) 		PF02571
(CbiJ) 		3 ALA A 232
VAL A 237
TRP A 240
 None
 0.94A 1tkqA-5c4rA:
undetectable		 1tkqA-5c4rA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwu NUCLEOPORIN NUP188

(Chaetomium
thermophilum) 		no annotation 3 ALA A1674
VAL A1664
TRP A1680
 None
 0.98A 1tkqA-5cwuA:
undetectable		 1tkqA-5cwuA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		3 ALA A 472
VAL A 402
TRP A 421
 None
 0.92A 1tkqA-5d6nA:
undetectable		 1tkqA-5d6nA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		3 ALA A 472
VAL A 402
TRP A 421
 None
 0.96A 1tkqA-5ey8A:
undetectable		 1tkqA-5ey8A:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h98 GEOBACTER
METALLIREDUCENS
SMUG1

(Geobacter
metallireducens) 		no annotation 3 ALA A  65
VAL A  69
TRP A 115
 None
 1.01A 1tkqA-5h98A:
undetectable		 1tkqA-5h98A:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h98 GEOBACTER
METALLIREDUCENS
SMUG1

(Geobacter
metallireducens) 		no annotation 3 ALA A 188
VAL A 186
TRP A 222
 None
 0.93A 1tkqA-5h98A:
undetectable		 1tkqA-5h98A:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir2 CELLULASE

(Parabacteroides
johnsonii) 		PF03737
(RraA-like) 		3 ALA A  80
VAL A 111
TRP A 113
 None
 0.96A 1tkqA-5ir2A:
undetectable		 1tkqA-5ir2A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		3 ALA A 494
VAL A 514
TRP A 541
 None
 1.00A 1tkqA-5k9tA:
undetectable		 1tkqA-5k9tA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		3 ALA B  52
VAL B 492
TRP B  56
 None
 0.95A 1tkqA-5lxzB:
undetectable		 1tkqA-5lxzB:
1.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH

(Eremococcus
coleocola) 		PF01566
(Nramp) 		3 ALA A 281
VAL A 279
TRP A  55
 None
 0.97A 1tkqA-5m8jA:
undetectable		 1tkqA-5m8jA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 3 ALA A 605
VAL A 607
TRP A 837
 None
 0.94A 1tkqA-5mhfA:
undetectable		 1tkqA-5mhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 3 ALA A  34
VAL A  32
TRP A  66
 None
 1.01A 1tkqA-5mrrA:
undetectable		 1tkqA-5mrrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE

(Thermomonospora
curvata) 		PF03781
(FGE-sulfatase) 		3 ALA A 291
VAL A 138
TRP A 117
 MRD  A 403 ( 3.8A)
None
None
 0.84A 1tkqA-5nyyA:
undetectable		 1tkqA-5nyyA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuj ALKZ

(Streptomyces
sahachiroi) 		PF06224
(HTH_42) 		3 ALA A 299
VAL A 297
TRP A   5
 None
 1.02A 1tkqA-5uujA:
undetectable		 1tkqA-5uujA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wn9 SCFV 2D10

(Homo sapiens) 		no annotation 3 ALA H 108
VAL H  34
TRP H  36
 None
 0.90A 1tkqA-5wn9H:
undetectable		 1tkqA-5wn9H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE

(Sphingobium sp.
SYK-6) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		3 ALA A 171
VAL A  53
TRP A  48
 None
 0.92A 1tkqA-5x1nA:
undetectable		 1tkqA-5x1nA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ALA A  13
VAL A 207
TRP A   8
 PEG  A 510 ( 3.7A)
None
None
 0.78A 1tkqA-5x8gA:
undetectable		 1tkqA-5x8gA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 3 ALA A 171
VAL A 130
TRP A 143
 None
 0.85A 1tkqA-5x9wA:
undetectable		 1tkqA-5x9wA:
2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn7 PUTATIVE RTX-TOXIN

(Vibrio
vulnificus) 		PF11647
(MLD) 		3 ALA A2812
VAL A2842
TRP A2817
 None
 1.01A 1tkqA-5xn7A:
undetectable		 1tkqA-5xn7A:
2.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yll BETA-1,4-MANNANASE

(Amphibacillus
xylanus) 		no annotation 3 ALA B 210
VAL B 212
TRP B 184
 None
 0.84A 1tkqA-5yllB:
undetectable		 1tkqA-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E

(Pyrococcus
furiosus) 		no annotation 3 ALA A  69
VAL A  71
TRP A  74
 None
 0.92A 1tkqA-6cfwA:
undetectable		 1tkqA-6cfwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 3 ALA A 496
VAL A 498
TRP A 484
 None
 1.02A 1tkqA-6dk2A:
undetectable		 1tkqA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehn CARBOHYDRATE
ESTERASE MZ0003

(unidentified
prokaryotic
organism) 		no annotation 3 ALA A 388
VAL A 386
TRP A 161
 None
 0.87A 1tkqA-6ehnA:
undetectable		 1tkqA-6ehnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6grw -

(-) 		no annotation 3 ALA A 214
VAL A 216
TRP A 219
 None
 0.69A 1tkqA-6grwA:
undetectable		 1tkqA-6grwA:
undetectable