SIMILAR PATTERNS OF AMINO ACIDS FOR 1TH6_A_OINA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a2a PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 GLY A  30
HIS A  48
ASP A  49
TYR A  52
 None
 0.26A 1th6A-1a2aA:
22.5		 1th6A-1a2aA:
62.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a2a PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 GLY A  31
HIS A  48
ASP A  49
TYR A  52
 None
 0.86A 1th6A-1a2aA:
22.5		 1th6A-1a2aA:
62.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ae7 PHOSPHOLIPASE A2

(Notechis
scutatus) 		PF00068
(Phospholip_A2_1) 		4 GLY A  30
HIS A  48
ASP A  49
TYR A  52
 None
 0.50A 1th6A-1ae7A:
16.2		 1th6A-1ae7A:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aok VIPOXIN COMPLEX

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		6 GLY B  30
HIS B  48
ASP B  49
TYR B  52
PRO B  68
LYS B  69
 ACT  B 134 (-3.7A)
ACT  B 134 (-3.6A)
ACT  B 134 ( 4.9A)
None
None
None
 1.01A 1th6A-1aokB:
20.7		 1th6A-1aokB:
56.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		4 GLY 1 218
HIS 1  94
TYR 1 221
PRO 1 153
 None
 1.17A 1th6A-1bev1:
undetectable		 1th6A-1bev1:
18.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpq PHOSPHOLIPASE A2

(Bos taurus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 CA  A 124 (-4.2A)
None
CA  A 124 (-2.1A)
None
None
 0.40A 1th6A-1bpqA:
18.0		 1th6A-1bpqA:
39.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpq PHOSPHOLIPASE A2

(Bos taurus) 		PF00068
(Phospholip_A2_1) 		4 GLY A  32
ASP A  49
TYR A  52
PRO A  68
 CA  A 124 (-4.2A)
CA  A 124 (-2.1A)
None
None
 1.11A 1th6A-1bpqA:
18.0		 1th6A-1bpqA:
39.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bun BETA2-BUNGAROTOXIN

(Bungarus
multicinctus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  63
 NA  A 121 (-4.4A)
None
NA  A 121 (-2.6A)
None
None
 0.76A 1th6A-1bunA:
17.3		 1th6A-1bunA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dpy PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  63
 NA  A 150 (-4.5A)
None
NA  A 150 (-2.5A)
None
None
 0.70A 1th6A-1dpyA:
17.3		 1th6A-1dpyA:
39.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		4 GLY M 411
TRP M 457
HIS M 436
TYR M 329
 None
GOL  M 936 (-3.7A)
None
None
 1.07A 1th6A-1dwaM:
undetectable		 1th6A-1dwaM:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 GLY C 180
TRP C 181
HIS C 211
PRO C 173
 None
 1.11A 1th6A-1ffvC:
undetectable		 1th6A-1ffvC:
19.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0z PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  63
 None
 0.78A 1th6A-1g0zA:
17.2		 1th6A-1g0zA:
39.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gmz PHOSPHOLIPASE A2

(Bothrops
pirajai) 		PF00068
(Phospholip_A2_1) 		4 HIS A  47
ASP A  48
TYR A  51
PRO A  59
 None
 0.34A 1th6A-1gmzA:
20.2		 1th6A-1gmzA:
64.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1god PROTEIN
(PHOSPHOLIPASE A2)

(Cerrophidion
godmani) 		PF00068
(Phospholip_A2_1) 		4 HIS A  48
TYR A  52
PRO A  68
LYS A  69
 None
 0.55A 1th6A-1godA:
20.9		 1th6A-1godA:
57.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gp7 PHOSPHOLIPASE A2

(Ophiophagus
hannah) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 CA  A1125 (-4.5A)
None
CA  A1125 (-2.4A)
None
None
 0.62A 1th6A-1gp7A:
16.9		 1th6A-1gp7A:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 GLY A  84
ASP A 536
TYR A 595
PRO A 594
 None
 1.14A 1th6A-1h39A:
undetectable		 1th6A-1h39A:
10.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ijl PHOSPHOLIPASE A2

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		4 GLY A  29
HIS A  47
ASP A  48
TYR A  51
 CA  A 203 (-4.5A)
None
CA  A 203 (-2.6A)
None
 0.57A 1th6A-1ijlA:
20.9		 1th6A-1ijlA:
52.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ijl PHOSPHOLIPASE A2

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		6 GLY A  31
HIS A  47
ASP A  48
TYR A  51
PRO A  59
LYS A  60
 CA  A 203 (-4.0A)
None
CA  A 203 (-2.6A)
None
None
None
 1.42A 1th6A-1ijlA:
20.9		 1th6A-1ijlA:
52.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jia PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 CA  A 134 (-4.5A)
None
CA  A 134 (-2.4A)
None
None
 0.70A 1th6A-1jiaA:
22.1		 1th6A-1jiaA:
61.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jia PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 GLY A  32
ASP A  49
TYR A  52
PRO A  68
 CA  A 134 (-4.2A)
CA  A 134 (-2.4A)
None
None
 1.19A 1th6A-1jiaA:
22.1		 1th6A-1jiaA:
61.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus) 		PF01979
(Amidohydro_1) 		4 GLY A 323
ASP A 414
TYR A 415
PRO A 340
 None
 1.19A 1th6A-1k1dA:
undetectable		 1th6A-1k1dA:
12.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8r PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 GLY A  30
HIS A  48
ASP A  49
TYR A  52
 BU1  A1002 (-4.3A)
None
CD  A1001 (-2.4A)
None
 0.44A 1th6A-1m8rA:
21.0		 1th6A-1m8rA:
54.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8r PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 GLY A  32
HIS A  48
TYR A  52
PRO A  68
 CD  A1001 (-3.9A)
None
None
None
 0.94A 1th6A-1m8rA:
21.0		 1th6A-1m8rA:
54.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8r PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 HIS A  48
ASP A  49
TYR A  52
PRO A  68
 None
CD  A1001 (-2.4A)
None
None
 0.36A 1th6A-1m8rA:
21.0		 1th6A-1m8rA:
54.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8t PHOSPHOLIPASE A2

(Ophiophagus
hannah) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 CA  A1001 (-4.3A)
None
CA  A1001 (-2.1A)
None
None
 0.58A 1th6A-1m8tA:
18.1		 1th6A-1m8tA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8t PHOSPHOLIPASE A2

(Ophiophagus
hannah) 		PF00068
(Phospholip_A2_1) 		4 GLY A  32
HIS A  48
TYR A  52
PRO A  68
 CA  A1001 (-4.2A)
None
None
None
 1.14A 1th6A-1m8tA:
18.1		 1th6A-1m8tA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh2 PHOSPHOLIPASE A2

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  63
 None
ACY  A 302 (-3.4A)
ACY  A 302 (-3.4A)
None
None
 0.67A 1th6A-1mh2A:
18.1		 1th6A-1mh2A:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh8 PHOSPHOLIPASE A2

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  63
 None
 0.62A 1th6A-1mh8A:
18.6		 1th6A-1mh8A:
38.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh8 PHOSPHOLIPASE A2

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		4 GLY A  31
ASP A  49
TYR A  28
PRO A  37
 None
 1.18A 1th6A-1mh8A:
18.6		 1th6A-1mh8A:
38.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLY B 701
HIS B 766
TYR B 386
PRO B 214
 None
 1.17A 1th6A-1n60B:
undetectable		 1th6A-1n60B:
8.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oz6 PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		4 GLY A  30
HIS A  48
ASP A  49
TYR A  52
 CA  A 134 (-4.9A)
None
CA  A 134 (-2.6A)
None
 0.72A 1th6A-1oz6A:
20.8		 1th6A-1oz6A:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oz6 PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		5 HIS A  48
ASP A  49
TYR A  52
PRO A  68
LYS A  69
 None
CA  A 134 (-2.6A)
None
None
None
 0.55A 1th6A-1oz6A:
20.8		 1th6A-1oz6A:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p7o PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 None
 0.50A 1th6A-1p7oA:
18.2		 1th6A-1p7oA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1po8 PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  63
 SHV  A 122 ( 3.7A)
SHV  A 122 (-4.1A)
NA  A 121 (-2.4A)
None
None
 0.71A 1th6A-1po8A:
17.4		 1th6A-1po8A:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1po8 PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		4 GLY A  32
HIS A  48
TYR A  52
PRO A  63
 NA  A 121 (-3.3A)
SHV  A 122 (-4.1A)
None
None
 0.97A 1th6A-1po8A:
17.4		 1th6A-1po8A:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2

(Crotalus atrox) 		no annotation 6 GLY R  30
HIS R  48
ASP R  49
TYR R  52
PRO R  68
LYS R  69
 None
 1.29A 1th6A-1pp2R:
21.3		 1th6A-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2

(Crotalus atrox) 		no annotation 6 GLY R  30
TRP R  31
HIS R  48
ASP R  49
TYR R  52
PRO R  68
 None
 1.41A 1th6A-1pp2R:
21.3		 1th6A-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1psh PHOSPHOLIPASE A2

(Naja naja) 		PF00068
(Phospholip_A2_1) 		4 GLY A  29
HIS A  47
ASP A  48
TYR A  51
 CA  A 120 (-4.4A)
None
CA  A 120 (-2.0A)
None
 0.65A 1th6A-1pshA:
18.2		 1th6A-1pshA:
38.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1psh PHOSPHOLIPASE A2

(Naja naja) 		PF00068
(Phospholip_A2_1) 		4 HIS A  47
ASP A  48
TYR A  51
PRO A  62
 None
CA  A 120 (-2.0A)
None
None
 0.29A 1th6A-1pshA:
18.2		 1th6A-1pshA:
38.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pwo PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 None
 0.74A 1th6A-1pwoA:
17.6		 1th6A-1pwoA:
36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q6v PHOSPHOLIPASE A2
VRV-PL-VIIIA

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		4 GLY A  30
HIS A  48
TYR A  52
PRO A  68
 None
 0.22A 1th6A-1q6vA:
25.3		 1th6A-1q6vA:
95.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		4 GLY A 109
HIS A 209
ASP A  97
PRO A 138
 None
SO4  A 500 (-4.0A)
None
None
 1.13A 1th6A-1u10A:
undetectable		 1th6A-1u10A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		4 GLY A 109
HIS A 209
ASP A 120
PRO A 138
 None
SO4  A 500 (-4.0A)
ZN  A 400 (-2.2A)
None
 1.16A 1th6A-1u10A:
undetectable		 1th6A-1u10A:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vap PHOSPHOLIPASE A2

(Agkistrodon
piscivorus) 		PF00068
(Phospholip_A2_1) 		6 GLY A  29
TRP A  30
HIS A  47
ASP A  48
TYR A  51
PRO A  59
 None
 0.73A 1th6A-1vapA:
21.6		 1th6A-1vapA:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vip PHOSPHOLIPASE A2

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
LYS A  69
 None
 1.17A 1th6A-1vipA:
21.6		 1th6A-1vipA:
57.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vip PHOSPHOLIPASE A2

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		5 HIS A  48
ASP A  49
TYR A  52
PRO A  68
LYS A  69
 None
 1.01A 1th6A-1vipA:
21.6		 1th6A-1vipA:
57.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vpi PHOSPHOLIPASE A2
INHIBITOR

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
ASP A  49
TYR A  52
PRO A  68
LYS A  69
 None
 0.99A 1th6A-1vpiA:
21.3		 1th6A-1vpiA:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y75 PHOSPHOLIPASE A2
ISOFORM 6

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		5 GLY B  30
HIS B  48
ASP B  49
TYR B  52
PRO B  63
 None
 0.73A 1th6A-1y75B:
17.9		 1th6A-1y75B:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zl7 HYPOTENSIVE
PHOSPHOLIPASE A2

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 GLY A  29
ASP A  48
TYR A  51
PRO A  59
LYS A  60
 None
CA  A1001 ( 2.3A)
None
None
None
 0.96A 1th6A-1zl7A:
19.6		 1th6A-1zl7A:
53.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zl7 HYPOTENSIVE
PHOSPHOLIPASE A2

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 HIS A  47
ASP A  48
TYR A  51
PRO A  59
LYS A  60
 None
CA  A1001 ( 2.3A)
None
None
None
 0.61A 1th6A-1zl7A:
19.6		 1th6A-1zl7A:
53.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ask ARTEMIN

(Homo sapiens) 		PF00019
(TGF_beta) 		4 GLY A 113
HIS A  54
ASP A  55
PRO A  75
 None
 1.14A 1th6A-2askA:
undetectable		 1th6A-2askA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0y PROCATHEPSIN S

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 GLY A  61
HIS A  47
ASP A  59
TYR A  58
 None
 1.16A 1th6A-2c0yA:
undetectable		 1th6A-2c0yA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guu ODCASE

(Plasmodium
vivax) 		PF00215
(OMPdecase) 		4 GLY A  92
HIS A 116
TYR A 112
PRO A 101
 None
 1.17A 1th6A-2guuA:
undetectable		 1th6A-2guuA:
15.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h4c PHOSPHOLIPASE A2-II

(Daboia
siamensis) 		PF00068
(Phospholip_A2_1) 		5 GLY B  30
HIS B  48
ASP B  49
TYR B  52
PRO B  68
 None
 0.74A 1th6A-2h4cB:
19.1		 1th6A-2h4cB:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h4c PHOSPHOLIPASE A2-II

(Daboia
siamensis) 		PF00068
(Phospholip_A2_1) 		4 HIS B  48
TYR B  52
PRO B  68
LYS B  69
 None
 1.16A 1th6A-2h4cB:
19.1		 1th6A-2h4cB:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h4c PHOSPHOLIPASE A2-III

(Daboia
siamensis) 		PF00068
(Phospholip_A2_1) 		5 HIS A  48
ASP A  49
TYR A  52
PRO A  68
LYS A  69
 None
 0.90A 1th6A-2h4cA:
20.1		 1th6A-2h4cA:
55.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0s AROMATIC AMINE
DEHYDROGENASE

(Alcaligenes
faecalis) 		PF06433
(Me-amine-dh_H) 		4 GLY A 327
HIS A 353
TYR A 291
PRO A 274
 None
 1.12A 1th6A-2i0sA:
undetectable		 1th6A-2i0sA:
16.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2osn PHOSPHOLIPASE A2
ISOFORM 3

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  63
 None
 0.98A 1th6A-2osnA:
17.1		 1th6A-2osnA:
36.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ph4 ZHAOERMIATOXIN

(Protobothrops
mangshanensis) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
TYR A  52
PRO A  68
LYS A  69
 PEG  A 401 ( 4.5A)
PEG  A 401 ( 4.9A)
None
None
None
 0.67A 1th6A-2ph4A:
19.4		 1th6A-2ph4A:
55.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		4 GLY A  30
HIS A  48
TYR A  52
PRO A  68
 None
 0.36A 1th6A-2qheA:
22.5		 1th6A-2qheA:
66.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		4 GLY A  31
HIS A  48
TYR A  52
PRO A  68
 None
 0.69A 1th6A-2qheA:
22.5		 1th6A-2qheA:
66.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8d AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 1

(Homo sapiens) 		PF00640
(PID) 		4 GLY A 414
TRP A 416
HIS A 409
ASP A 410
 None
 1.14A 1th6A-3d8dA:
undetectable		 1th6A-3d8dA:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dih PHOSPHOLIPASE A2
HOMOLOG, AMMODYTIN L

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 GLY A  29
HIS A  47
TYR A  51
PRO A  59
 None
 0.43A 1th6A-3dihA:
22.4		 1th6A-3dihA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dih PHOSPHOLIPASE A2
HOMOLOG, AMMODYTIN L

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 HIS A  47
TYR A  51
PRO A  59
LYS A  60
 None
 0.75A 1th6A-3dihA:
22.4		 1th6A-3dihA:
65.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		5 GLY A1200
TRP A 654
HIS A 854
TYR A1210
PRO A 228
 None
 1.48A 1th6A-3egwA:
undetectable		 1th6A-3egwA:
6.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8g PHOSPHOLIPASE A2,
AMMODYTOXIN A

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 HIS A  47
ASP A  48
TYR A  51
PRO A  59
 None
 0.34A 1th6A-3g8gA:
22.3		 1th6A-3g8gA:
80.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8g PHOSPHOLIPASE A2,
AMMODYTOXIN A

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 HIS A  47
TYR A  51
PRO A  59
LYS A  60
 None
 0.88A 1th6A-3g8gA:
22.3		 1th6A-3g8gA:
80.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 GLY A 300
HIS A  85
ASP A 297
TYR A 328
 CA  A 603 (-4.3A)
None
CA  A 603 (-3.4A)
None
 1.09A 1th6A-3hjrA:
undetectable		 1th6A-3hjrA:
9.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p2p PHOSPHOLIPASE A2

(Sus scrofa) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 CA  A 125 (-4.3A)
None
CA  A 125 (-2.1A)
None
None
 0.54A 1th6A-3p2pA:
18.1		 1th6A-3p2pA:
41.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 GLY A1177
ASP A  69
PRO A  77
LYS A  76
 None
 1.12A 1th6A-3pieA:
undetectable		 1th6A-3pieA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 GLY A 360
ASP A 332
TYR A 331
PRO A 256
 None
 0.88A 1th6A-3sutA:
undetectable		 1th6A-3sutA:
11.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9m PHOSPHOLIPASE A2
ISOZYME PA-11

(Pseudechis
australis) 		PF00068
(Phospholip_A2_1) 		6 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  62
LYS A  63
 EDO  A 201 (-3.5A)
EDO  A 201 ( 4.0A)
CA  A 205 (-2.2A)
EDO  A 201 ( 4.8A)
None
PEG  A 206 (-2.2A)
 0.66A 1th6A-3v9mA:
17.9		 1th6A-3v9mA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vbz PHOSPHOLIPASE A2
HOMOLOG, TAIPOXIN
BETA CHAIN

(Oxyuranus
scutellatus) 		PF00068
(Phospholip_A2_1) 		4 HIS A  48
ASP A  49
TYR A  52
PRO A  62
 None
 0.49A 1th6A-3vbzA:
17.8		 1th6A-3vbzA:
36.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		4 GLY A 130
HIS A 257
ASP A 258
TYR A 317
 None
 1.16A 1th6A-3vsvA:
undetectable		 1th6A-3vsvA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Sphingopyxis
sp. 113P3) 		no annotation 4 GLY A  49
TRP A 108
HIS A 279
TYR A 251
 SO4  A 901 ( 3.7A)
None
SO4  A 901 ( 4.4A)
None
 1.19A 1th6A-3wlaA:
undetectable		 1th6A-3wlaA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbw SIALIDASE
(NEURAMINIDASE)

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		4 GLY A 269
TRP A 290
ASP A 235
PRO A 273
 None
 1.01A 1th6A-4bbwA:
undetectable		 1th6A-4bbwA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		4 GLY A 265
TRP A 286
ASP A 231
PRO A 269
 None
 1.02A 1th6A-4fj6A:
undetectable		 1th6A-4fj6A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcm THIOREDOXIN
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		4 GLY A 282
ASP A 280
TYR A 258
PRO A 242
 None
 1.11A 1th6A-4gcmA:
undetectable		 1th6A-4gcmA:
15.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h0s BASIC PHOSPHOLIPASE
A2 HOMOLOG CTS-R6

(Trimeresurus
stejnegeri) 		PF00068
(Phospholip_A2_1) 		4 GLY A  30
HIS A  48
TYR A  52
LYS A  69
 None
 1.00A 1th6A-4h0sA:
20.6		 1th6A-4h0sA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN

(Bacteroides
caccae) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		4 GLY A 285
TRP A 306
ASP A 251
PRO A 289
 None
 1.00A 1th6A-4q6kA:
undetectable		 1th6A-4q6kA:
13.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rfp ACIDIC PHOSPHOLIPASE
A2 5

(Trimeresurus
stejnegeri) 		PF00068
(Phospholip_A2_1) 		4 HIS A  47
ASP A  48
TYR A  51
PRO A  59
 None
 0.43A 1th6A-4rfpA:
20.1		 1th6A-4rfpA:
53.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		4 GLY A  29
HIS A  47
TYR A  51
PRO A  59
 None
ZN  A 201 (-3.1A)
None
None
 0.44A 1th6A-4wtbA:
21.3		 1th6A-4wtbA:
55.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp3 MYCOCEROSIC ACID
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF14765
(PS-DH) 		4 GLY A 905
TRP A 919
HIS A 928
PRO A1096
 None
 1.16A 1th6A-5bp3A:
undetectable		 1th6A-5bp3A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egn ESTERASE

(uncultured
bacterium) 		PF12697
(Abhydrolase_6) 		4 GLY A  33
TRP A  35
ASP A  52
TYR A  12
 None
 1.04A 1th6A-5egnA:
undetectable		 1th6A-5egnA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		4 GLY A 147
HIS A 290
TYR A 211
PRO A 213
 None
ZN  A 502 (-3.3A)
None
None
 1.19A 1th6A-5fcaA:
undetectable		 1th6A-5fcaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 GLY A 888
TRP A 965
TYR A 892
PRO A 880
 None
 1.02A 1th6A-5ihrA:
undetectable		 1th6A-5ihrA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no5 ABYA5

(Verrucosispora) 		no annotation 4 GLY A 332
HIS A 327
ASP A 329
PRO A 338
 None
 1.18A 1th6A-5no5A:
undetectable		 1th6A-5no5A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owc -

(-) 		no annotation 6 GLY A  28
HIS A  46
ASP A  47
TYR A  50
PRO A  60
LYS A  61
 AYZ  A 202 ( 3.5A)
AYZ  A 202 (-4.0A)
CA  A 201 ( 2.2A)
AYZ  A 202 ( 4.9A)
None
None
 0.57A 1th6A-5owcA:
19.4		 1th6A-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swj PROBABLE ATP
SYNTHASE SPAL/MXIB

(Shigella
flexneri) 		PF00006
(ATP-synt_ab) 		4 GLY A 190
ASP A 217
TYR A 218
PRO A  98
 None
 0.96A 1th6A-5swjA:
undetectable		 1th6A-5swjA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tfv BASIC PHOSPHOLIPASE
A2 MYOTOXIN III

(Bothrops asper) 		PF00068
(Phospholip_A2_1) 		4 HIS A  48
ASP A  49
TYR A  52
PRO A  68
 None
 0.87A 1th6A-5tfvA:
20.9		 1th6A-5tfvA:
68.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tfv BASIC PHOSPHOLIPASE
A2 MYOTOXIN III

(Bothrops asper) 		PF00068
(Phospholip_A2_1) 		4 HIS A  48
TYR A  52
PRO A  68
LYS A  69
 None
 0.65A 1th6A-5tfvA:
20.9		 1th6A-5tfvA:
68.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txw PEPTIDASE

(Thermococcus
thioreducens) 		PF01965
(DJ-1_PfpI) 		4 GLY A  10
HIS A  44
ASP A  13
PRO A 151
 None
 1.12A 1th6A-5txwA:
undetectable		 1th6A-5txwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 GLY A 369
HIS A 231
PRO A 171
LYS A 170
 None
 1.14A 1th6A-5ww1A:
undetectable		 1th6A-5ww1A:
14.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wzm GROUP IIE SECRETORY
PHOSPHOLIPASE A2

(Homo sapiens) 		no annotation 6 GLY A  28
HIS A  46
ASP A  47
TYR A  50
PRO A  60
LYS A  61
 CA  A 210 (-4.3A)
None
CA  A 210 (-2.2A)
None
CL  A 201 (-3.7A)
CL  A 201 (-4.0A)
 1.05A 1th6A-5wzmA:
20.4		 1th6A-5wzmA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wzm GROUP IIE SECRETORY
PHOSPHOLIPASE A2

(Homo sapiens) 		no annotation 5 GLY A  30
HIS A  46
TYR A  50
PRO A  60
LYS A  61
 CA  A 210 (-4.2A)
None
None
CL  A 201 (-3.7A)
CL  A 201 (-4.0A)
 1.27A 1th6A-5wzmA:
20.4		 1th6A-5wzmA:
34.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN

(Shewanella
loihica) 		no annotation 4 GLY A 221
HIS A 198
ASP A 192
LYS A   1
 None
 1.17A 1th6A-5x8zA:
undetectable		 1th6A-5x8zA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y51 -

(-) 		no annotation 4 GLY A  47
HIS A  41
TYR A  57
PRO A 178
 None
 1.18A 1th6A-5y51A:
undetectable		 1th6A-5y51A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9r HYDROXYETHYLPHOSPHON
ATE DIOXYGENASE

(Streptomyces
albus) 		no annotation 4 GLY A 335
HIS A 339
TYR A 152
PRO A 186
 None
 1.12A 1th6A-6b9rA:
undetectable		 1th6A-6b9rA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 4 GLY A  30
HIS A  48
TYR A  52
PRO A  68
 PE4  A 201 ( 3.6A)
None
None
None
 0.31A 1th6A-6ce2A:
21.1		 1th6A-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE

(Schizosaccharomyces
pombe) 		no annotation 4 GLY A  15
HIS A  50
TYR A  21
PRO A 289
 SAH  A 401 (-3.4A)
None
None
None
 0.99A 1th6A-6fdfA:
undetectable		 1th6A-6fdfA:
22.31