SIMILAR PATTERNS OF AMINO ACIDS FOR 1TDN_A_LEUA487_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		7 ARG A  90
ASN A 208
HIS A 223
PHE A 227
TYR A 372
ILE A 430
TRP A 465
 CIT  A 526 ( 3.2A)
CIT  A 526 (-4.2A)
CIT  A 526 (-3.6A)
CIT  A 526 (-3.9A)
CIT  A 526 ( 4.8A)
FAD  A 527 (-4.7A)
None
 0.55A 1tdnA-1f8rA:
61.3		 1tdnA-1f8rA:
86.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		4 ARG A  90
HIS A 223
PHE A 227
ILE A 374
 CIT  A 526 ( 3.2A)
CIT  A 526 (-3.6A)
CIT  A 526 (-3.9A)
CIT  A 526 ( 4.9A)
 0.92A 1tdnA-1f8rA:
61.3		 1tdnA-1f8rA:
86.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8u EOSINOPHIL GRANULE
MAJOR BASIC PROTEIN
1

(Homo sapiens) 		PF00059
(Lectin_C) 		4 ASN A  35
PHE A  77
ILE A  40
TRP A 102
 None
GOL  A1123 (-4.2A)
None
None
 1.42A 1tdnA-1h8uA:
undetectable		 1tdnA-1h8uA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf0 OBELIN

(Obelia
longissima) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 PHE A  72
TYR A  28
ILE A  50
TRP A 114
 CZH  A 197 ( 4.6A)
None
None
CZH  A 197 (-3.7A)
 0.82A 1tdnA-1jf0A:
undetectable		 1tdnA-1jf0A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		4 ARG A 102
PHE A 233
TYR A 368
ILE A 111
 None
 1.48A 1tdnA-1lmlA:
undetectable		 1tdnA-1lmlA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nba N-CARBAMOYLSARCOSINE
AMIDOHYDROLASE

(Arthrobacter
sp.) 		PF00857
(Isochorismatase) 		4 HIS A  61
TYR A  96
ILE A 115
TRP A  56
 None
None
None
SO4  A 400 (-4.1A)
 1.08A 1tdnA-1nbaA:
undetectable		 1tdnA-1nbaA:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		7 ARG A  90
ASN A 208
HIS A 223
PHE A 227
TYR A 372
ILE A 430
TRP A 465
 LVG  A 491 (-3.5A)
LVG  A 487 (-3.9A)
LVG  A 487 (-2.5A)
LVG  A 487 (-3.9A)
LVG  A 491 ( 4.9A)
FAD  A 488 (-4.7A)
None
 0.23A 1tdnA-1tdkA:
64.2		 1tdnA-1tdkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		4 ARG A  90
HIS A 223
PHE A 227
ILE A 374
 LVG  A 491 (-3.5A)
LVG  A 487 (-2.5A)
LVG  A 487 (-3.9A)
LVG  A 491 ( 4.6A)
 0.91A 1tdnA-1tdkA:
64.2		 1tdnA-1tdkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		4 ASN A 208
HIS A 223
PHE A 227
TYR A 356
 LVG  A 487 (-3.9A)
LVG  A 487 (-2.5A)
LVG  A 487 (-3.9A)
None
 1.41A 1tdnA-1tdkA:
64.2		 1tdnA-1tdkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225

(Thermotoga
maritima) 		PF04041
(Glyco_hydro_130) 		4 ARG A 108
HIS A 231
PHE A 283
ILE A 182
 None
 1.45A 1tdnA-1vkdA:
undetectable		 1tdnA-1vkdA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		4 ASN A 223
HIS A 216
PHE A 236
ILE A 202
 MN  A 283 (-2.8A)
None
None
None
 1.30A 1tdnA-1zaoA:
undetectable		 1tdnA-1zaoA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		4 ARG A 145
HIS A 196
TYR A 248
ILE A 203
 None
ZN  A 501 (-3.3A)
None
None
 1.41A 1tdnA-1zliA:
undetectable		 1tdnA-1zliA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c20 UDP-GLUCOSE
4-EPIMERASE

(Bacillus
anthracis) 		PF01370
(Epimerase) 		4 ASN A  94
HIS A  73
PHE A 115
TYR A 142
 None
 1.14A 1tdnA-2c20A:
3.5		 1tdnA-2c20A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASN A 411
PHE A 422
ILE A 434
TRP A 432
 None
 1.15A 1tdnA-2fqdA:
undetectable		 1tdnA-2fqdA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ASN A 759
HIS A 752
PHE A 773
ILE A 738
 MG  A 404 (-4.5A)
None
None
None
 1.27A 1tdnA-2henA:
undetectable		 1tdnA-2henA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ASN A 369
HIS A 362
PHE A 383
ILE A 348
 1BM  A 499 (-4.1A)
None
None
None
 1.16A 1tdnA-2hk5A:
undetectable		 1tdnA-2hk5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jak SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		4 HIS A 243
PHE A 235
TYR A 190
ILE A 204
 None
 1.44A 1tdnA-2jakA:
undetectable		 1tdnA-2jakA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ASN A 605
PHE A 600
TYR A 622
ILE A 767
 None
 1.50A 1tdnA-2np0A:
undetectable		 1tdnA-2np0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE

(Salmonella
enterica) 		PF03352
(Adenine_glyco) 		4 ASN A 173
HIS A 175
ILE A 135
TRP A   6
 None
ZN  A 201 (-3.1A)
None
PGE  A 701 (-3.4A)
 1.48A 1tdnA-2ofkA:
undetectable		 1tdnA-2ofkA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5u UDP-GLUCOSE
4-EPIMERASE

(Thermus
thermophilus) 		PF01370
(Epimerase) 		4 ASN A  93
HIS A  72
PHE A 114
TYR A 143
 None
None
None
NAD  A1118 (-4.4A)
 1.28A 1tdnA-2p5uA:
2.8		 1tdnA-2p5uA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw6 UNCHARACTERIZED
PROTEIN YGID

(Escherichia
coli) 		PF02900
(LigB) 		4 ARG A 157
HIS A 214
PHE A 153
ILE A 251
 None
 1.32A 1tdnA-2pw6A:
undetectable		 1tdnA-2pw6A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq6 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 271
PHE A 272
TYR A  68
ILE A  86
 None
 1.33A 1tdnA-2qq6A:
undetectable		 1tdnA-2qq6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 ASN A 805
HIS A 798
PHE A 819
ILE A 784
 None
 1.17A 1tdnA-2r2pA:
undetectable		 1tdnA-2r2pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A 144
HIS A 137
PHE A 162
ILE A 123
 MG  A1304 ( 4.2A)
None
None
None
 1.36A 1tdnA-2w4kA:
undetectable		 1tdnA-2w4kA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		4 ARG A 207
ASN A 106
PHE A 155
TRP A 280
 A2G  A1428 (-3.3A)
A2G  A1428 (-3.8A)
GAL  A1429 ( 4.5A)
GAL  A1429 ( 3.6A)
 1.09A 1tdnA-2w7yA:
undetectable		 1tdnA-2w7yA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A 540
HIS A 533
PHE A 558
ILE A 519
 None
 1.14A 1tdnA-2wntA:
undetectable		 1tdnA-2wntA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ASN A 751
HIS A 744
PHE A 765
ILE A 730
 None
 1.30A 1tdnA-2xyuA:
undetectable		 1tdnA-2xyuA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		4 ARG A 359
ASN A 430
HIS A 432
TYR A 347
 PE5  A 531 (-3.8A)
None
EDO  A 579 (-4.0A)
PE5  A 531 (-3.6A)
 1.43A 1tdnA-2yeqA:
undetectable		 1tdnA-2yeqA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 ARG A 447
HIS A 387
PHE A 386
ILE A  49
 HAS  A1016 ( 3.1A)
HAS  A1015 (-3.2A)
HAS  A1016 ( 4.1A)
HAS  A1015 (-4.1A)
 1.33A 1tdnA-2yevA:
undetectable		 1tdnA-2yevA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ASN A 372
HIS A 365
PHE A 386
ILE A 351
 None
 1.17A 1tdnA-2zv7A:
undetectable		 1tdnA-2zv7A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A 144
HIS A 137
PHE A 162
ILE A 123
 None
 1.31A 1tdnA-3bqrA:
undetectable		 1tdnA-3bqrA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ey7 BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
III-RELATED PROTEIN

(Vibrio cholerae) 		PF00903
(Glyoxalase) 		4 ASN A  53
HIS A  55
PHE A  61
ILE A  20
 None
 1.11A 1tdnA-3ey7A:
undetectable		 1tdnA-3ey7A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff4 UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF13380
(CoA_binding_2) 		4 ARG A  82
ASN A  -1
HIS A  29
PHE A 119
 None
 1.22A 1tdnA-3ff4A:
3.1		 1tdnA-3ff4A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ASN A 343
HIS A 349
PHE A 350
TRP A 312
 None
None
None
EDO  A8008 (-4.0A)
 1.49A 1tdnA-3gbdA:
undetectable		 1tdnA-3gbdA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ARG A 118
PHE A  45
TYR A  51
ILE A 124
 None
 1.19A 1tdnA-3gdeA:
undetectable		 1tdnA-3gdeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ASN B1199
HIS A  94
PHE A  97
ILE A 331
 None
 1.28A 1tdnA-3h0gB:
undetectable		 1tdnA-3h0gB:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjz TRANSALDOLASE B

(Prochlorococcus
marinus) 		PF00923
(TAL_FSA) 		4 ASN A 172
PHE A 280
TYR A 215
ILE A 276
 None
 1.13A 1tdnA-3hjzA:
undetectable		 1tdnA-3hjzA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ASN A 180
HIS A 173
PHE A 196
ILE A 159
 None
 1.29A 1tdnA-3hkoA:
undetectable		 1tdnA-3hkoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnq VIRULENCE PROTEIN
STM3117

(Salmonella
enterica) 		PF00903
(Glyoxalase) 		4 ASN A  67
HIS A  69
PHE A  75
ILE A  34
 None
 1.16A 1tdnA-3hnqA:
undetectable		 1tdnA-3hnqA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9x MUTT/NUDIX FAMILY
PROTEIN

(Listeria
innocua) 		PF00293
(NUDIX) 		4 ARG A 113
HIS A 159
PHE A 157
ILE A  49
 None
GOL  A 186 (-4.1A)
GOL  A 186 ( 4.2A)
None
 1.12A 1tdnA-3i9xA:
undetectable		 1tdnA-3i9xA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ASN A 180
HIS A 173
PHE A 194
ILE A 159
 None
 1.29A 1tdnA-3iecA:
undetectable		 1tdnA-3iecA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ASN A 180
HIS A 173
PHE A 194
ILE A 189
 None
 1.44A 1tdnA-3iecA:
undetectable		 1tdnA-3iecA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		7 ARG A  90
ASN A 208
HIS A 223
PHE A 227
TYR A 372
ILE A 430
TRP A 465
 None
None
None
None
FAD  A 487 (-4.9A)
FAD  A 487 (-4.7A)
None
 0.44A 1tdnA-3kveA:
59.8		 1tdnA-3kveA:
89.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		4 ARG A  90
HIS A 223
PHE A 227
ILE A 374
 None
 0.96A 1tdnA-3kveA:
59.8		 1tdnA-3kveA:
89.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 ASN A 682
HIS A 675
PHE A 721
ILE A 661
 ANP  A 877 ( 4.8A)
None
None
None
 1.27A 1tdnA-3lltA:
undetectable		 1tdnA-3lltA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A 163
HIS A 156
PHE A 180
ILE A 142
 None
 1.24A 1tdnA-3lm5A:
undetectable		 1tdnA-3lm5A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtq PUTATIVE
PHOSPHOENOLPYRUVATE-
DEPENDENT SUGAR
PHOSPHOTRANSFERASE
SYSTEM (PTS)
PERMEASE

(Klebsiella
pneumoniae) 		PF03610
(EIIA-man) 		4 ARG A  54
HIS A   4
PHE A  55
ILE A  31
 None
 1.24A 1tdnA-3mtqA:
undetectable		 1tdnA-3mtqA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A 210
HIS A 203
PHE A 224
ILE A 189
 None
 1.32A 1tdnA-3nuuA:
undetectable		 1tdnA-3nuuA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		4 ARG A  68
PHE A 216
TYR A 369
TRP A 476
 EPE  A 602 ( 3.1A)
EPE  A 602 (-3.5A)
EPE  A 602 (-4.9A)
None
 0.66A 1tdnA-3x0vA:
37.8		 1tdnA-3x0vA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 ASN A 641
PHE A 636
TYR A 658
ILE A 803
 None
 1.49A 1tdnA-3zuqA:
undetectable		 1tdnA-3zuqA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avo BETA-1,4-EXOCELLULAS
E

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		5 ARG A 458
ASN A 363
HIS A 327
ILE A 455
TRP A 391
 None
 1.50A 1tdnA-4avoA:
undetectable		 1tdnA-4avoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ASN A 221
HIS A 214
PHE A 235
ILE A 200
 30K  A1365 (-4.4A)
None
None
None
 1.25A 1tdnA-4aw5A:
undetectable		 1tdnA-4aw5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 ASN A 144
HIS A 137
PHE A 158
ILE A 123
 STU  A1550 (-4.3A)
None
None
None
 1.34A 1tdnA-4cfhA:
undetectable		 1tdnA-4cfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		4 ASN A 138
HIS A 131
PHE A 152
ILE A 117
 None
 1.32A 1tdnA-4eqmA:
undetectable		 1tdnA-4eqmA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		4 ASN A1159
HIS A1152
PHE A1178
ILE A1136
 None
 1.34A 1tdnA-4f0gA:
undetectable		 1tdnA-4f0gA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ASN A 981
HIS A 974
PHE A 995
ILE A 960
 IZA  A2001 ( 4.7A)
None
None
None
 1.21A 1tdnA-4gl9A:
undetectable		 1tdnA-4gl9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ASN A 954
HIS A 947
PHE A 968
ILE A 933
 None
 1.25A 1tdnA-4hviA:
undetectable		 1tdnA-4hviA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		4 ASN A 134
HIS A 126
TYR A 106
ILE A 172
 None
LLP  A 230 ( 3.5A)
None
None
 1.37A 1tdnA-4j5uA:
undetectable		 1tdnA-4j5uA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 ASN A 391
HIS A 384
PHE A 405
ILE A 370
 None
 1.31A 1tdnA-4lggA:
undetectable		 1tdnA-4lggA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx3 DNA POLYMERASE III,
ALPHA SUBUNIT
NUCLEIC ACID
BINDING, OB-FOLD,
TRNA/HELICASE-TYPE

(Nostoc
punctiforme;
Nostoc
punctiforme) 		no annotation
no annotation 		4 ARG A  50
ASN B  36
HIS A  72
ILE A  18
 None
 1.41A 1tdnA-4lx3A:
undetectable		 1tdnA-4lx3A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 ASN A 744
HIS A 737
PHE A 758
ILE A 723
 None
 1.22A 1tdnA-4p2kA:
undetectable		 1tdnA-4p2kA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pds SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ASN A 324
HIS A 317
PHE A 340
ILE A 303
 ANP  A 601 (-3.3A)
None
None
None
 1.27A 1tdnA-4pdsA:
undetectable		 1tdnA-4pdsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ARG A 920
ASN A 891
TYR A 881
ILE A 927
 None
 1.41A 1tdnA-4pj6A:
undetectable		 1tdnA-4pj6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq1 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 ASN A 139
HIS A  58
PHE A  59
ILE A 134
 None
 1.42A 1tdnA-4qq1A:
undetectable		 1tdnA-4qq1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A 171
HIS A 164
PHE A 185
ILE A 150
 None
 1.33A 1tdnA-4qtbA:
undetectable		 1tdnA-4qtbA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 ASN A 146
HIS A 139
PHE A 160
ILE A 125
 STU  A 601 (-4.2A)
None
None
None
 1.43A 1tdnA-4rewA:
undetectable		 1tdnA-4rewA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE

(Brucella
abortus) 		PF01370
(Epimerase) 		4 ASN A  95
HIS A  74
PHE A 116
TYR A 143
 None
 1.34A 1tdnA-4twrA:
3.4		 1tdnA-4twrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 ASN A 152
HIS A 145
PHE A 166
ILE A 131
 None
 1.35A 1tdnA-4xrlA:
undetectable		 1tdnA-4xrlA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 ASN A 413
HIS A 512
TYR A 140
ILE A 655
 None
None
XYL  A2015 (-4.6A)
XYL  A2015 ( 4.2A)
 1.40A 1tdnA-4xwhA:
undetectable		 1tdnA-4xwhA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b22 NECTIN-3

(Mus musculus) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 ASN A  67
HIS A  47
PHE A  65
ILE A  22
 None
 1.36A 1tdnA-5b22A:
undetectable		 1tdnA-5b22A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ASN A 490
HIS A 799
ILE A 462
TRP A 792
 None
 1.42A 1tdnA-5bwdA:
undetectable		 1tdnA-5bwdA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyp SEPTIN-9

(Homo sapiens) 		PF00735
(Septin) 		4 ASN A 213
HIS A 269
PHE A 216
ILE A 276
 None
 1.19A 1tdnA-5cypA:
undetectable		 1tdnA-5cypA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 HIS A 691
PHE A 666
ILE A 480
TRP A 415
 TRS  A1001 (-4.0A)
TRS  A1001 (-4.5A)
None
None
 1.22A 1tdnA-5dkxA:
undetectable		 1tdnA-5dkxA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ASN A 183
HIS A 176
PHE A 197
ILE A 162
 5RC  A4000 (-4.1A)
None
None
None
 1.31A 1tdnA-5es1A:
undetectable		 1tdnA-5es1A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ASN A1028
HIS A1021
PHE A1042
ILE A1007
 5U3  A1200 (-4.7A)
None
None
None
 1.27A 1tdnA-5f1zA:
undetectable		 1tdnA-5f1zA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ASN A 879
HIS A 872
PHE A 893
ILE A 858
 None
 1.20A 1tdnA-5fm2A:
undetectable		 1tdnA-5fm2A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		4 HIS A  48
PHE A  37
TYR A  64
ILE A  30
 None
 1.46A 1tdnA-5gs7A:
undetectable		 1tdnA-5gs7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 HIS A 698
PHE A 673
ILE A 488
TRP A 423
 5GF  A1021 (-4.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.1A)
 1.22A 1tdnA-5hjrA:
undetectable		 1tdnA-5hjrA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 ASN A 144
HIS A 137
PHE A 158
ILE A 123
 STU  A 601 (-4.3A)
None
None
None
 1.34A 1tdnA-5isoA:
undetectable		 1tdnA-5isoA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgd PLATELET
GLYCOPROTEIN 4

(Homo sapiens) 		PF01130
(CD36) 		4 ARG A 273
ASN A 306
PHE A 312
TYR A 276
 None
 1.48A 1tdnA-5lgdA:
undetectable		 1tdnA-5lgdA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A 280
HIS A 273
PHE A 296
ILE A 259
 7A7  A 501 ( 4.8A)
None
None
None
 1.26A 1tdnA-5lxdA:
undetectable		 1tdnA-5lxdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 4 ARG A 277
ASN A 261
TYR A 214
ILE A 189
 CL  A 402 (-4.0A)
None
None
None
 1.32A 1tdnA-5m86A:
undetectable		 1tdnA-5m86A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1q N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
DOMAIN-CONTAINING
PROTEIN
SAOUHSC_02979

(Staphylococcus
aureus) 		PF01832
(Glucosaminidase)
PF05257
(CHAP) 		4 ARG A 321
HIS A 465
TYR A 482
ILE A 350
 None
 1.44A 1tdnA-5t1qA:
undetectable		 1tdnA-5t1qA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		7 ARG A  90
ASN A 208
HIS A 223
PHE A 227
TYR A 372
ILE A 430
TRP A 465
 None
None
None
None
None
FAD  A 501 (-4.6A)
FAD  A 501 (-4.8A)
 0.30A 1tdnA-5ts5A:
61.2		 1tdnA-5ts5A:
89.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		4 ARG A  90
HIS A 223
PHE A 227
ILE A 374
 None
 0.91A 1tdnA-5ts5A:
61.2		 1tdnA-5ts5A:
89.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		4 ASN A 208
HIS A 223
PHE A 227
TYR A 356
 None
 1.46A 1tdnA-5ts5A:
61.2		 1tdnA-5ts5A:
89.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 4 ASN A 350
HIS A 349
PHE A 353
ILE A 300
 None
ZN  A 401 (-3.2A)
None
None
 1.45A 1tdnA-5utiA:
undetectable		 1tdnA-5utiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE

(Sphingobium sp.
SYK-6) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ARG A 122
ASN A 371
TYR A  31
TRP A 256
 DHB  A 502 (-3.7A)
EDO  A 503 (-4.8A)
DHB  A 502 (-4.6A)
THG  A 501 ( 3.3A)
 1.35A 1tdnA-5x1nA:
undetectable		 1tdnA-5x1nA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE

(Chromobacterium
sp. USM2) 		PF07167
(PhaC_N) 		4 ASN A 415
HIS A 324
PHE A 411
ILE A 432
 None
 1.46A 1tdnA-5xavA:
undetectable		 1tdnA-5xavA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 4 ASN A 324
HIS A 317
PHE A 340
ILE A 303
 None
 1.26A 1tdnA-5xzwA:
undetectable		 1tdnA-5xzwA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 4 ASN A 340
HIS A 333
PHE A 356
ILE A 319
 None
 1.29A 1tdnA-5y86A:
undetectable		 1tdnA-5y86A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2g L-AMINO ACID OXIDASE

(Naja atra) 		no annotation 6 ARG A 109
ASN A 227
PHE A 246
TYR A 389
ILE A 446
TRP A 481
 None
None
None
None
FAD  A 604 (-4.5A)
FAD  A 604 (-4.7A)
 0.47A 1tdnA-5z2gA:
59.6		 1tdnA-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 4 ASN A1008
HIS A1001
PHE A1022
ILE A 987
 MG  A1202 ( 2.5A)
None
None
None
 1.21A 1tdnA-6c7yA:
undetectable		 1tdnA-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 4 ASN A 187
HIS A 180
PHE A 201
ILE A 166
 None
 1.30A 1tdnA-6c9dA:
undetectable		 1tdnA-6c9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 ARG A2011
HIS A1940
TYR A1988
ILE A1950
 None
 1.42A 1tdnA-6ez8A:
undetectable		 1tdnA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 4 ASN A 879
HIS A 872
PHE A 893
ILE A 858
 None
 1.21A 1tdnA-6fekA:
undetectable		 1tdnA-6fekA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml INO80

(Chaetomium
thermophilum) 		no annotation 4 ASN G1035
HIS G1034
ILE G1083
TRP G1053
 None
 1.49A 1tdnA-6fmlG:
undetectable		 1tdnA-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 ASN A 293
HIS A 286
PHE A 326
ILE A 272
 None
 1.23A 1tdnA-6fyoA:
undetectable		 1tdnA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 ASN A 293
HIS A 286
PHE A 326
ILE A 272
 None
 1.23A 1tdnA-6fyvA:
undetectable		 1tdnA-6fyvA:
undetectable