SIMILAR PATTERNS OF AMINO ACIDS FOR 1TD7_A_NFLA2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a2a PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
ILE A   9
GLY A  30
CYH A  45
PHE A 106
 None
 0.52A 1td7A-1a2aA:
18.8		 1td7A-1a2aA:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpq PHOSPHOLIPASE A2

(Bos taurus) 		PF00068
(Phospholip_A2_1) 		5 ILE A   9
PHE A  22
GLY A  30
TYR A  69
PHE A 106
 None
None
CA  A 124 (-4.2A)
None
None
 0.45A 1td7A-1bpqA:
20.8		 1td7A-1bpqA:
54.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpq PHOSPHOLIPASE A2

(Bos taurus) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
ILE A   9
PHE A  22
GLY A  30
PHE A 106
 None
None
None
CA  A 124 (-4.2A)
None
 0.61A 1td7A-1bpqA:
20.8		 1td7A-1bpqA:
54.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dpy PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		6 LEU A   2
LYS A   6
ILE A   9
TRP A  19
GLY A  30
PHE A 101
 None
None
None
None
NA  A 150 (-4.5A)
None
 0.92A 1td7A-1dpyA:
20.0		 1td7A-1dpyA:
61.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0z PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		6 LEU A   2
LYS A   6
ILE A   9
TRP A  19
GLY A  30
PHE A 101
 None
 0.80A 1td7A-1g0zA:
19.7		 1td7A-1g0zA:
59.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gp7 PHOSPHOLIPASE A2

(Ophiophagus
hannah) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
ILE A   9
TRP A  19
GLY A  30
PHE A 106
 None
None
None
CA  A1125 (-4.5A)
None
 0.86A 1td7A-1gp7A:
21.4		 1td7A-1gp7A:
52.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh8 PHOSPHOLIPASE A2

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		5 ILE A   9
TRP A  19
PHE A  22
GLY A  30
PHE A 101
 None
 0.30A 1td7A-1mh8A:
24.5		 1td7A-1mh8A:
84.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU A1243
ILE A1178
PHE A1199
GLY A1193
PHE A1239
 None
 1.35A 1td7A-1n5xA:
undetectable		 1td7A-1n5xA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 468
ILE A 471
PHE A 501
GLY A 512
PHE A 450
 None
 1.45A 1td7A-1ozhA:
undetectable		 1td7A-1ozhA:
11.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p7o PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		6 LEU A   2
ILE A   9
PHE A  22
GLY A  30
TYR A  69
PHE A 106
 None
 0.55A 1td7A-1p7oA:
20.8		 1td7A-1p7oA:
58.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pwo PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		6 LEU A   2
ILE A   9
PHE A  22
GLY A  30
TYR A  69
PHE A 106
 None
 0.62A 1td7A-1pwoA:
20.2		 1td7A-1pwoA:
58.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptomyces
sp. R61) 		PF00144
(Beta-lactamase) 		5 LEU A  72
ILE A 187
PHE A  67
GLY A 283
PHE A 250
 None
 1.39A 1td7A-1sdeA:
undetectable		 1td7A-1sdeA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptomyces
sp. R61) 		PF00144
(Beta-lactamase) 		5 LEU A  73
ILE A 187
PHE A  67
GLY A 283
PHE A 250
 None
 1.08A 1td7A-1sdeA:
undetectable		 1td7A-1sdeA:
15.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y75 PHOSPHOLIPASE A2
ISOFORM 5

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		5 ILE A   9
TRP A  19
PHE A  22
GLY A  30
PHE A 101
 None
NAG  A 301 (-4.7A)
None
NAG  A 301 (-4.0A)
None
 0.37A 1td7A-1y75A:
22.8		 1td7A-1y75A:
86.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		5 LEU A 433
ILE A 365
GLY A 426
CYH A 386
PHE A 405
 None
 1.34A 1td7A-1z3zA:
undetectable		 1td7A-1z3zA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1s HYPOTHETICAL PROTEIN

(Methanosarcina
mazei) 		PF07929
(PRiA4_ORF3) 		5 LEU A  65
LYS A  67
ILE A  68
PHE A  55
PHE A  34
 None
 1.45A 1td7A-2i1sA:
undetectable		 1td7A-2i1sA:
17.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2osn PHOSPHOLIPASE A2
ISOFORM 3

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		6 LEU A   4
LYS A   8
ILE A  11
TRP A  19
GLY A  30
PHE A 101
 None
 0.75A 1td7A-2osnA:
19.5		 1td7A-2osnA:
61.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  54
ILE A 168
PHE A  61
TYR A  42
PHE A 164
 None
 1.38A 1td7A-2v7bA:
undetectable		 1td7A-2v7bA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		5 LEU A 666
ILE A 209
GLY A 842
CYH A 837
PHE A 833
 None
 1.13A 1td7A-3egwA:
undetectable		 1td7A-3egwA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		5 LYS A 620
ILE A 619
GLY A 560
TYR A 589
PHE A 614
 None
 1.10A 1td7A-3hjeA:
undetectable		 1td7A-3hjeA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipw HYDROLASE TATD
FAMILY PROTEIN

(Entamoeba
histolytica) 		PF01026
(TatD_DNase) 		5 LEU A  88
ILE A 138
GLY A  79
CYH A 101
TYR A  93
 None
 1.31A 1td7A-3ipwA:
undetectable		 1td7A-3ipwA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		5 LEU A 151
ILE A 176
PHE A 144
TYR A 114
PHE A 168
 None
 1.28A 1td7A-3ln3A:
undetectable		 1td7A-3ln3A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		5 LEU A 585
ILE A 549
GLY A 556
CYH A 474
PHE A 470
 None
 1.24A 1td7A-3m62A:
undetectable		 1td7A-3m62A:
8.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p2p PHOSPHOLIPASE A2

(Sus scrofa) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
ILE A   9
PHE A  22
GLY A  30
PHE A 106
 None
None
None
CA  A 125 (-4.3A)
None
 0.44A 1td7A-3p2pA:
21.6		 1td7A-3p2pA:
57.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p2p PHOSPHOLIPASE A2

(Sus scrofa) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
ILE A   9
PHE A  22
TYR A  69
PHE A 106
 None
 0.79A 1td7A-3p2pA:
21.6		 1td7A-3p2pA:
57.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU C1243
ILE C1178
PHE C1199
GLY C1193
PHE C1239
 None
 1.30A 1td7A-3sr6C:
undetectable		 1td7A-3sr6C:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		5 LEU A  97
ILE A 219
PHE A  91
GLY A 319
PHE A 283
 None
 1.05A 1td7A-3wwxA:
undetectable		 1td7A-3wwxA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		no annotation 5 LEU A 419
ILE A 395
PHE A 377
GLY A 323
TYR A 423
 None
 1.39A 1td7A-4po6A:
undetectable		 1td7A-4po6A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE

(Burkholderia
pseudomallei) 		PF01063
(Aminotran_4) 		5 LEU A 132
ILE A 265
PHE A 201
GLY A 198
TYR A 131
 None
None
None
ALA  A 401 (-4.0A)
EDO  A 402 (-3.7A)
 1.37A 1td7A-4whxA:
undetectable		 1td7A-4whxA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7p ALKALINE D-PEPTIDASE

(Bacillus cereus) 		PF00144
(Beta-lactamase) 		5 LEU A  85
ILE A 199
PHE A  79
GLY A 297
PHE A 262
 None
 1.04A 1td7A-4y7pA:
undetectable		 1td7A-4y7pA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LEU A 629
ILE A 665
PHE A 658
TYR A 628
PHE A 653
 None
 1.40A 1td7A-4ztxA:
undetectable		 1td7A-4ztxA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3b UNCHARACTERIZED
PROTEIN HI_1552

(Haemophilus
influenzae) 		PF04301
(DUF452) 		5 LEU A 151
ILE A  99
GLY A  19
TYR A  44
PHE A 178
 None
None
IPA  A 302 (-3.6A)
None
None
 1.19A 1td7A-5h3bA:
undetectable		 1td7A-5h3bA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7z PUTATIVE SECRETED
ENDOGLYCOSYLCERAMIDA
SE

(Rhodococcus
hoagii) 		PF00150
(Cellulase) 		5 LEU A  52
ILE A 337
GLY A  55
TYR A 388
PHE A 340
 None
 1.44A 1td7A-5j7zA:
undetectable		 1td7A-5j7zA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe) 		PF10156
(Med17) 		5 LEU W 305
ILE W 310
GLY W 235
CYH W 401
PHE W 397
 None
 1.31A 1td7A-5n9jW:
undetectable		 1td7A-5n9jW:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sup ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 121
ILE A  77
PHE A  64
TYR A 150
PHE A  82
 None
None
ADP  A1000 ( 4.6A)
None
ADP  A1000 ( 3.7A)
 1.48A 1td7A-5supA:
undetectable		 1td7A-5supA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suq ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 121
ILE A  77
PHE A  64
TYR A 150
PHE A  82
 None
 1.48A 1td7A-5suqA:
undetectable		 1td7A-5suqA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkq NETRIN-1

(Homo sapiens) 		no annotation 5 LEU A 136
ILE A 161
PHE A 220
GLY A 282
PHE A 174
 None
 1.37A 1td7A-6fkqA:
undetectable		 1td7A-6fkqA:
20.87