SIMILAR PATTERNS OF AMINO ACIDS FOR 1TCO_C_FK5C509_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 TRP A 352
SER A 353
PHE A 356
GLU A 359
 None
 0.63A 1tcoA-3ll8A:
57.4		 1tcoA-3ll8A:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orj SUGAR-BINDING
PROTEIN

(Bacteroides
ovatus) 		no annotation 4 TRP A 355
SER A 329
PHE A 331
GLU A 412
 None
 1.32A 1tcoA-3orjA:
0.0		 1tcoA-3orjA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		4 TRP A 685
SER A 686
PHE A 689
GLU A 692
 None
 0.52A 1tcoA-4il1A:
54.3		 1tcoA-4il1A:
99.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkq GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		4 TRP B 287
SER B 288
PHE B 199
GLU B 197
 None
 1.28A 1tcoA-4nkqB:
0.0		 1tcoA-4nkqB:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 TRP A 361
SER A 362
PHE A 365
GLU A 368
 None
 0.49A 1tcoA-4oraA:
56.0		 1tcoA-4oraA:
84.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4orb SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Mus musculus) 		PF00149
(Metallophos) 		4 TRP A 352
SER A 353
PHE A 356
GLU A 359
 None
 0.41A 1tcoA-4orbA:
56.8		 1tcoA-4orbA:
99.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		4 TRP B 287
SER B 288
PHE B 199
GLU B 197
 None
 1.35A 1tcoA-4rs1B:
0.0		 1tcoA-4rs1B:
22.61