SIMILAR PATTERNS OF AMINO ACIDS FOR 1TBF_A_VIAA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccz PROTEIN (CD58)

(Homo sapiens) 		PF05790
(C2-set) 		5 LEU A  67
LEU A  90
VAL A  35
ALA A  36
PHE A  15
 None
 1.13A 1tbfA-1cczA:
undetectable		 1tbfA-1cczA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		5 TYR C 334
LEU A  97
LEU A  93
ALA C 496
PHE C 503
 HEM  A 605 ( 4.8A)
None
None
None
None
 1.23A 1tbfA-1d7wC:
0.0		 1tbfA-1d7wC:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dju AROMATIC
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		5 LEU A 310
LEU A 383
VAL A 345
ALA A 346
PHE A 335
 None
 1.09A 1tbfA-1djuA:
undetectable		 1tbfA-1djuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee8 MUTM (FPG) PROTEIN

(Thermus
thermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 LEU A 146
LEU A 190
VAL A 159
ALA A 157
PHE A 135
 None
 1.24A 1tbfA-1ee8A:
undetectable		 1tbfA-1ee8A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hds HEMOGLOBIN S (DEOXY)
(BETA CHAIN)

(Odocoileus
virginianus) 		PF00042
(Globin) 		5 LEU B  67
LEU B 109
VAL B 136
ALA B 139
LEU B  87
 None
None
None
None
HEM  B 146 ( 4.6A)
 1.24A 1tbfA-1hdsB:
0.0		 1tbfA-1hdsB:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j32 ASPARTATE
AMINOTRANSFERASE

(Phormidium
lapideum) 		PF00155
(Aminotran_1_2) 		5 LEU A 313
LEU A 384
VAL A 348
ALA A 349
PHE A 338
 None
 1.04A 1tbfA-1j32A:
undetectable		 1tbfA-1j32A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9o ALASERPIN

(Manduca sexta) 		PF00079
(Serpin) 		5 LEU I  54
LEU I 296
ALA I 309
LEU I 312
PHE I 305
 None
 1.13A 1tbfA-1k9oI:
undetectable		 1tbfA-1k9oI:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 TYR A 209
LEU A 217
LEU A  75
ALA A 207
LEU A 241
 None
 1.11A 1tbfA-1qhoA:
undetectable		 1tbfA-1qhoA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si9 STABLE PROTEIN 1

(Populus tremula) 		PF07876
(Dabb) 		5 LEU A  13
LEU A  97
ALA A  88
LEU A  36
PHE A  93
 GOL  A 109 ( 4.1A)
None
None
None
None
 1.23A 1tbfA-1si9A:
undetectable		 1tbfA-1si9A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		5 LEU A 397
LEU A 359
ALA A 337
LEU A 414
PHE A 421
 None
 1.26A 1tbfA-1szsA:
undetectable		 1tbfA-1szsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4u HEMOGLOBIN BETA
CHAIN

(Thunnus thynnus) 		PF00042
(Globin) 		5 LEU B  68
LEU B 110
VAL B 137
ALA B 140
LEU B  88
 None
None
None
None
HEM  B 147 (-4.9A)
 1.11A 1tbfA-1v4uB:
undetectable		 1tbfA-1v4uB:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		5 LEU A 307
VAL A 284
ALA A 285
LEU A  80
MET A  91
 None
FMN  A 501 ( 4.2A)
FMN  A 501 (-2.9A)
None
None
 1.27A 1tbfA-1vcgA:
undetectable		 1tbfA-1vcgA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmu HEMOGLOBIN A AND D
BETA CHAIN

(Aldabrachelys
gigantea) 		PF00042
(Globin) 		5 LEU B  68
LEU B 110
VAL B 137
ALA B 140
LEU B  88
 None
None
None
None
HEM  B 201 (-4.3A)
 1.27A 1tbfA-1wmuB:
undetectable		 1tbfA-1wmuB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn9 THE HYPOTHETICAL
PROTEIN (TT1805)

(Thermus
thermophilus) 		PF11432
(DUF3197) 		5 LEU A  80
LEU A  21
VAL A  59
ALA A  47
LEU A  33
 None
 1.28A 1tbfA-1wn9A:
undetectable		 1tbfA-1wn9A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 211
VAL A 380
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.79A 1tbfA-1zklA:
38.5		 1tbfA-1zklA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 LEU A   9
LEU A  82
ALA A  59
LEU A  31
PHE A  51
 None
 1.25A 1tbfA-2ffhA:
undetectable		 1tbfA-2ffhA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		5 LEU A 333
LEU A 418
VAL A  61
ALA A  62
PHE A 380
 None
 1.22A 1tbfA-2horA:
undetectable		 1tbfA-2horA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4r V-TYPE ATP SYNTHASE
SUBUNIT F

(Archaeoglobus
fulgidus) 		PF01990
(ATP-synt_F) 		5 TYR A  25
LEU A  63
LEU A  41
VAL A   7
PHE A  75
 None
 1.14A 1tbfA-2i4rA:
undetectable		 1tbfA-2i4rA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		5 LEU A 122
LEU A 132
ALA A 323
LEU A  82
GLN A  78
 None
None
GUN  A 503 ( 4.1A)
None
GUN  A 503 (-3.4A)
 1.15A 1tbfA-2i9uA:
undetectable		 1tbfA-2i9uA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A   9
LEU A  82
ALA A  59
LEU A  31
PHE A  51
 None
 1.23A 1tbfA-2ng1A:
undetectable		 1tbfA-2ng1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE

(Helicobacter
pylori) 		PF00852
(Glyco_transf_10) 		5 LEU A 129
VAL A 136
ALA A 141
LEU A 167
PHE A   2
 None
 1.11A 1tbfA-2nzxA:
undetectable		 1tbfA-2nzxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		5 LEU A 162
LEU A 146
VAL A 126
LEU A 133
PHE A 151
 None
 1.24A 1tbfA-2o6qA:
undetectable		 1tbfA-2o6qA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6r VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A 130
LEU A 114
VAL A  94
LEU A 101
PHE A 119
 None
 1.25A 1tbfA-2o6rA:
undetectable		 1tbfA-2o6rA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6s VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF11921
(DUF3439)
PF12799
(LRR_4)
PF13855
(LRR_8) 		5 LEU A 130
LEU A 114
VAL A  94
LEU A 101
PHE A 119
 None
 1.26A 1tbfA-2o6sA:
undetectable		 1tbfA-2o6sA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkd SLAM FAMILY MEMBER 5

(Homo sapiens) 		no annotation 5 LEU A  79
LEU A 106
VAL A  40
ALA A  41
PHE A  19
 None
 1.05A 1tbfA-2pkdA:
undetectable		 1tbfA-2pkdA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rt5 MSX2-INTERACTING
PROTEIN

(Homo sapiens) 		PF07744
(SPOC) 		5 LEU A3639
LEU A3575
VAL A3563
LEU A3555
GLN A3627
 None
 1.29A 1tbfA-2rt5A:
undetectable		 1tbfA-2rt5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0n MALE-SPECIFIC LETHAL
1 HOMOLOG
MALE-SPECIFIC LETHAL
3 HOMOLOG

(Homo sapiens;
Mus musculus) 		PF05712
(MRG)
no annotation 		5 LEU A 463
LEU A 261
ALA A 479
LEU A 477
PHE E 577
 None
 1.08A 1tbfA-2y0nA:
undetectable		 1tbfA-2y0nA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
BETA

(Cavia porcellus) 		PF00042
(Globin) 		5 LEU B  68
LEU B 110
VAL B 137
ALA B 140
LEU B  88
 None
None
None
None
HEM  B 401 ( 4.7A)
 1.27A 1tbfA-3a0gB:
undetectable		 1tbfA-3a0gB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		5 LEU A 386
LEU A 303
ALA A 456
LEU A 463
PHE A 428
 None
 1.27A 1tbfA-3a2qA:
undetectable		 1tbfA-3a2qA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		5 LEU A 386
LEU A 303
LEU A 463
GLN A 433
PHE A 428
 None
 1.21A 1tbfA-3a2qA:
undetectable		 1tbfA-3a2qA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asa LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydia
trachomatis) 		PF00155
(Aminotran_1_2) 		5 LEU A  80
LEU A 289
VAL A  51
ALA A  52
PHE A 234
 None
 1.21A 1tbfA-3asaA:
undetectable		 1tbfA-3asaA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 612
LEU A 725
LEU A 765
VAL A 782
ALA A 783
MET A 816
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.0A)
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.36A 1tbfA-3b2rA:
45.7		 1tbfA-3b2rA:
94.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bj1 HEMOGLOBIN BETA

(Perca
flavescens) 		PF00042
(Globin) 		5 LEU B  68
LEU B 110
VAL B 137
ALA B 140
LEU B  88
 None
None
None
None
HEM  B 148 (-4.7A)
 1.11A 1tbfA-3bj1B:
undetectable		 1tbfA-3bj1B:
17.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 612
LEU A 725
LEU A 765
VAL A 782
ALA A 783
GLN A 817
PHE A 820
 None
None
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.6A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.28A 1tbfA-3bjcA:
48.3		 1tbfA-3bjcA:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 612
LEU A 725
LEU A 765
VAL A 782
MET A 816
GLN A 817
PHE A 820
 None
None
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.71A 1tbfA-3bjcA:
48.3		 1tbfA-3bjcA:
37.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cy5 HEMOGLOBIN SUBUNIT
BETA

(Bubalus bubalis) 		PF00042
(Globin) 		5 LEU B  68
LEU B 110
VAL B 137
ALA B 140
LEU B  88
 None
None
None
None
HEM  B 147 (-4.2A)
 1.19A 1tbfA-3cy5B:
undetectable		 1tbfA-3cy5B:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		5 LEU A 428
ALA A  57
LEU A 436
MET A 382
PHE A 430
 None
 1.27A 1tbfA-3gjuA:
undetectable		 1tbfA-3gjuA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi0 PUTATIVE
EXOPOLYPHOSPHATASE

(Agrobacterium
fabrum) 		PF02541
(Ppx-GppA) 		5 LEU A 200
LEU A 153
ALA A 276
LEU A 244
PHE A 208
 None
 1.23A 1tbfA-3hi0A:
6.4		 1tbfA-3hi0A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 TYR A 655
LEU A 770
LEU A 809
GLN A 859
PHE A 862
 None
 0.72A 1tbfA-3ibjA:
38.4		 1tbfA-3ibjA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3p IPAH9.8

(Shigella
flexneri) 		PF14496
(NEL) 		5 LEU A 531
LEU A 370
VAL A 463
ALA A 462
PHE A 454
 None
 1.16A 1tbfA-3l3pA:
undetectable		 1tbfA-3l3pA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		5 LEU A 113
LEU A  97
VAL A  77
LEU A  84
PHE A 102
 None
 1.21A 1tbfA-3m19A:
undetectable		 1tbfA-3m19A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		5 LEU A 137
LEU A 121
VAL A 101
LEU A 108
PHE A 126
 None
 1.24A 1tbfA-3m19A:
undetectable		 1tbfA-3m19A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF00073
(Rhv) 		5 LEU C 178
LEU C 225
ALA C 229
LEU C 170
PHE C 125
 None
 1.23A 1tbfA-3napC:
undetectable		 1tbfA-3napC:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		5 LEU A  40
LEU A 242
VAL A 190
LEU A 206
PHE A 178
 None
 1.28A 1tbfA-3rrwA:
undetectable		 1tbfA-3rrwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 TYR A 230
LEU A 318
LEU A 183
VAL A 235
ALA A 234
 None
 1.23A 1tbfA-3s2uA:
undetectable		 1tbfA-3s2uA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		5 LEU X  63
LEU X 127
VAL X 250
ALA X 251
LEU X 111
 None
 1.28A 1tbfA-3ss7X:
undetectable		 1tbfA-3ss7X:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU A 372
LEU A 432
VAL A 605
ALA A 604
LEU A 381
 None
 1.10A 1tbfA-3thzA:
undetectable		 1tbfA-3thzA:
17.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 524
LEU A 635
LEU A 675
GLN A 726
PHE A 729
 C1L  A   1 ( 4.8A)
None
C1L  A   1 (-4.3A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
 0.58A 1tbfA-3ui7A:
44.4		 1tbfA-3ui7A:
38.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo9 VARIABLE LYMPHOCYTE
RECEPTOR C

(Lethenteron
camtschaticum) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 145
LEU A 129
VAL A 109
LEU A 116
PHE A 134
 None
 1.24A 1tbfA-3wo9A:
undetectable		 1tbfA-3wo9A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 149
LEU A 171
VAL A 189
ALA A 190
PHE A 162
 None
 1.14A 1tbfA-3wpeA:
undetectable		 1tbfA-3wpeA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv6 GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 LEU A 203
LEU A 226
VAL A 287
ALA A 288
LEU A  11
 None
 1.09A 1tbfA-3wv6A:
undetectable		 1tbfA-3wv6A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		5 TYR A 258
LEU A 281
VAL A 254
ALA A 253
LEU A  49
 None
 1.28A 1tbfA-4aysA:
undetectable		 1tbfA-4aysA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN BETA
CHAIN

(Eleginops
maclovinus) 		PF00042
(Globin) 		5 LEU B  68
LEU B 110
VAL B 137
ALA B 140
LEU B  88
 None
None
None
None
HEM  B 202 (-4.7A)
 1.12A 1tbfA-4esaB:
undetectable		 1tbfA-4esaB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 499
VAL A 425
ALA A 424
MET A 329
PHE A 486
 None
 1.19A 1tbfA-4h7uA:
undetectable		 1tbfA-4h7uA:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 655
LEU A 770
LEU A 809
GLN A 859
PHE A 862
 None
 0.53A 1tbfA-4htzA:
43.8		 1tbfA-4htzA:
34.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		no annotation 5 LEU B  85
LEU B  69
VAL B  49
LEU B  56
PHE B  74
 None
 1.20A 1tbfA-4k5uB:
undetectable		 1tbfA-4k5uB:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 232
LEU A 216
VAL A 168
LEU A 182
PHE A 221
 None
 1.14A 1tbfA-4kt1A:
undetectable		 1tbfA-4kt1A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 235
LEU A 219
VAL A 171
LEU A 185
PHE A 224
 None
 1.16A 1tbfA-4li2A:
undetectable		 1tbfA-4li2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqj HEMOGLOBIN SUBUNIT
GAMMA-2

(Homo sapiens) 		PF00042
(Globin) 		5 LEU B  68
LEU B 110
VAL B 137
ALA B 140
LEU B  88
 None
None
None
None
HEM  B 201 (-4.6A)
 1.27A 1tbfA-4mqjB:
undetectable		 1tbfA-4mqjB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxi UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01323
(DSBA) 		5 LEU A  18
LEU A 106
VAL A  74
ALA A  77
LEU A 136
 None
 0.92A 1tbfA-4nxiA:
undetectable		 1tbfA-4nxiA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		5 LEU A 178
VAL A 127
ALA A 215
LEU A 277
PHE A 285
 None
PMK  A 401 (-3.0A)
PMK  A 401 (-2.7A)
PMK  A 401 ( 3.8A)
PMK  A 401 ( 3.6A)
 1.25A 1tbfA-4onoA:
undetectable		 1tbfA-4onoA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio cholerae) 		PF02508
(Rnf-Nqr)
PF03116
(NQR2_RnfD_RnfE) 		5 LEU D 180
VAL B 189
ALA B 190
LEU E 188
PHE B 211
 None
 1.24A 1tbfA-4p6vD:
undetectable		 1tbfA-4p6vD:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq8 DESIGNED PROTEIN
OR465

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A 147
LEU A 131
VAL A 111
LEU A 118
PHE A 136
 None
 1.26A 1tbfA-4pq8A:
undetectable		 1tbfA-4pq8A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq8 DESIGNED PROTEIN
OR465

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A 171
LEU A 155
VAL A 135
LEU A 142
PHE A 160
 None
 1.28A 1tbfA-4pq8A:
undetectable		 1tbfA-4pq8A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq8 DESIGNED PROTEIN
OR465

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A 195
LEU A 179
VAL A 159
LEU A 166
PHE A 184
 None
 1.24A 1tbfA-4pq8A:
undetectable		 1tbfA-4pq8A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq8 DESIGNED PROTEIN
OR465

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A 219
LEU A 203
VAL A 183
LEU A 190
PHE A 208
 None
 1.23A 1tbfA-4pq8A:
undetectable		 1tbfA-4pq8A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 232
LEU A 216
VAL A 168
LEU A 182
PHE A 221
 None
 1.13A 1tbfA-4qxeA:
undetectable		 1tbfA-4qxeA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxf LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A 232
LEU A 216
VAL A 168
LEU A 182
PHE A 221
 None
 1.21A 1tbfA-4qxfA:
undetectable		 1tbfA-4qxfA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 139
LEU A 123
VAL A 103
LEU A 110
PHE A 128
 None
 1.28A 1tbfA-4r5cA:
undetectable		 1tbfA-4r5cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 163
LEU A 147
VAL A 127
LEU A 134
PHE A 152
 None
 1.27A 1tbfA-4r5cA:
undetectable		 1tbfA-4r5cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 187
LEU A 171
VAL A 151
LEU A 158
PHE A 176
 None
 1.21A 1tbfA-4r5cA:
undetectable		 1tbfA-4r5cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 211
LEU A 195
VAL A 175
LEU A 182
PHE A 200
 None
 1.28A 1tbfA-4r5cA:
undetectable		 1tbfA-4r5cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 139
LEU A 123
VAL A 103
LEU A 110
PHE A 128
 None
 1.28A 1tbfA-4r5dA:
undetectable		 1tbfA-4r5dA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 163
LEU A 147
VAL A 127
LEU A 134
PHE A 152
 None
 1.22A 1tbfA-4r5dA:
undetectable		 1tbfA-4r5dA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 187
LEU A 171
VAL A 151
LEU A 158
PHE A 176
 None
 1.23A 1tbfA-4r5dA:
undetectable		 1tbfA-4r5dA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 211
LEU A 195
VAL A 175
LEU A 182
PHE A 200
 None
 1.26A 1tbfA-4r5dA:
undetectable		 1tbfA-4r5dA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6f LEUCINE RICH REPEAT
DLRR_I

(synthetic
construct) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A 139
LEU A 123
VAL A 103
LEU A 110
PHE A 128
 None
 1.25A 1tbfA-4r6fA:
undetectable		 1tbfA-4r6fA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6f LEUCINE RICH REPEAT
DLRR_I

(synthetic
construct) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A 243
LEU A 248
VAL A 287
LEU A 297
PHE A 280
 None
 1.26A 1tbfA-4r6fA:
undetectable		 1tbfA-4r6fA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K

(synthetic
construct) 		PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 139
LEU A 123
VAL A 103
LEU A 110
PHE A 128
 None
 1.26A 1tbfA-4r6gA:
undetectable		 1tbfA-4r6gA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6j LUCINE RICH REPEATS
DLRR_H

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A 139
LEU A 123
VAL A 103
LEU A 110
PHE A 128
 None
 1.25A 1tbfA-4r6jA:
undetectable		 1tbfA-4r6jA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00156
(Pribosyltran) 		5 LEU A 152
LEU A  28
ALA A  38
LEU A  75
GLN A  34
 LEU  A 152 ( 0.6A)
LEU  A  28 ( 0.6A)
ALA  A  38 ( 0.0A)
LEU  A  75 ( 0.6A)
GLN  A  34 ( 0.6A)
 1.25A 1tbfA-4rhyA:
undetectable		 1tbfA-4rhyA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 381
LEU A 367
VAL A 347
LEU A 354
PHE A 370
 None
 1.18A 1tbfA-4ufsA:
undetectable		 1tbfA-4ufsA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 LEU A 336
LEU A 266
VAL A 281
ALA A 294
LEU A 103
 None
 1.12A 1tbfA-4w1wA:
undetectable		 1tbfA-4w1wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wkw UNCHARACTERIZED
PROTEIN

(Mycobacterium
leprae) 		PF01323
(DSBA) 		5 LEU A  18
LEU A 106
VAL A  74
ALA A  77
LEU A 136
 None
 0.94A 1tbfA-4wkwA:
undetectable		 1tbfA-4wkwA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu4 HEMOGLOBIN

(Helogale
parvula) 		PF00042
(Globin) 		5 LEU B  68
LEU B 110
VAL B 137
ALA B 140
LEU B  88
 None
None
None
None
HEM  B 201 ( 4.7A)
 1.26A 1tbfA-4yu4B:
undetectable		 1tbfA-4yu4B:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5c LRRTM

(synthetic
construct) 		PF13855
(LRR_8) 		5 LEU A 157
LEU A 141
VAL A 121
LEU A 128
PHE A 146
 None
 1.18A 1tbfA-5a5cA:
undetectable		 1tbfA-5a5cA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5c LRRTM

(synthetic
construct) 		PF13855
(LRR_8) 		5 LEU A 229
LEU A 213
VAL A 193
LEU A 200
PHE A 218
 None
 1.24A 1tbfA-5a5cA:
undetectable		 1tbfA-5a5cA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5de0 DEFERROCHELATASE

(Vibrio cholerae) 		PF04261
(Dyp_perox) 		5 LEU A  21
LEU A  34
VAL A  55
ALA A   7
GLN A   5
 None
 1.18A 1tbfA-5de0A:
undetectable		 1tbfA-5de0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 429
LEU A 187
VAL A 297
ALA A 295
LEU A 333
 None
 1.24A 1tbfA-5erbA:
undetectable		 1tbfA-5erbA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il6 POLYKETIDE
SYNTHASE/NONRIBOSOMA
L PEPTIDE SYNTHETASE
HYBRID RZXB

(Pseudomonas
protegens) 		PF14765
(PS-DH) 		5 LEU A4566
LEU A4637
VAL A4573
ALA A4575
LEU A4534
 None
 1.15A 1tbfA-5il6A:
undetectable		 1tbfA-5il6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		5 TYR A 500
LEU A 263
LEU A 259
ALA A 662
PHE A 669
 HEM  A 812 ( 4.3A)
None
None
None
None
 1.24A 1tbfA-5mfaA:
undetectable		 1tbfA-5mfaA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uff RBC36

(Petromyzon
marinus) 		no annotation 5 LEU A 104
LEU A  88
VAL A  68
LEU A  75
PHE A  93
 None
 1.26A 1tbfA-5uffA:
undetectable		 1tbfA-5uffA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhf 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		5 LEU V 394
LEU V 338
VAL V 367
ALA V 366
LEU V 379
 None
 1.20A 1tbfA-5vhfV:
undetectable		 1tbfA-5vhfV:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxl INVASIN IPAD

(Shigella
flexneri) 		PF06511
(IpaD) 		5 TYR A 276
LEU A 195
LEU A 174
ALA A 278
PHE A 283
 None
 1.19A 1tbfA-5vxlA:
undetectable		 1tbfA-5vxlA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk4 VARIABLE LYMPHOCYTE
RECEPTOR 39

(Petromyzon
marinus) 		no annotation 5 LEU D 104
LEU D  88
VAL D  68
LEU D  75
PHE D  93
 None
 1.28A 1tbfA-5wk4D:
undetectable		 1tbfA-5wk4D:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk4 VARIABLE LYMPHOCYTE
RECEPTOR 39

(Petromyzon
marinus) 		no annotation 5 LEU D 128
LEU D 112
VAL D  92
LEU D  99
PHE D 117
 None
 1.25A 1tbfA-5wk4D:
undetectable		 1tbfA-5wk4D:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 5 TYR A 112
LEU A 224
VAL A 102
ALA A 101
LEU A  66
 None
 1.20A 1tbfA-5wmmA:
undetectable		 1tbfA-5wmmA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		5 LEU A 305
LEU A 339
VAL A 326
LEU A 221
PHE A 226
 None
 1.27A 1tbfA-5xe0A:
undetectable		 1tbfA-5xe0A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum) 		no annotation 5 LEU A  33
VAL A  63
ALA A 108
MET A 117
PHE A  90
 None
 1.00A 1tbfA-5z7rA:
undetectable		 1tbfA-5z7rA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2

(Petromyzon
marinus) 		no annotation 5 LEU C 128
LEU C 112
VAL C  92
LEU C  99
PHE C 117
 None
 1.26A 1tbfA-6bxaC:
undetectable		 1tbfA-6bxaC:
15.09