SIMILAR PATTERNS OF AMINO ACIDS FOR 1T9W_A_NFNA6002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4e CATALASE A

(Saccharomyces
cerevisiae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 MET A 485
ALA A 189
PHE A 486
ARG A 122
 None
 1.34A 1t9wA-1a4eA:
0.0		 1t9wA-1a4eA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 GLN A  82
ALA A 744
PHE A 544
GLU A 645
 None
 1.33A 1t9wA-1b0kA:
0.0		 1t9wA-1b0kA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 GLN A 468
PHE A 213
ARG A 333
ASN A 207
 None
 1.11A 1t9wA-1ex0A:
0.0		 1t9wA-1ex0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 ALA A 312
PHE A 245
ARG A 302
ASN A 309
 None
 1.32A 1t9wA-1gqjA:
0.0		 1t9wA-1gqjA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqp RFCS

(Pyrococcus
furiosus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 ALA A 109
PHE A 100
ARG A  76
ASN A  74
 None
 1.28A 1t9wA-1iqpA:
2.6		 1t9wA-1iqpA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		4 ALA A6291
PHE A6268
ARG A6339
ASN A6342
 None
 1.35A 1t9wA-1koaA:
0.0		 1t9wA-1koaA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 MET A  38
ALA A  15
PHE A  78
ARG A  50
 ACT  A1871 ( 4.7A)
None
ACT  A1871 (-3.0A)
None
 0.97A 1t9wA-1lqtA:
undetectable		 1t9wA-1lqtA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 MET A 200
GLN A 284
PHE A 178
ARG A 133
 None
 1.38A 1t9wA-1mpxA:
0.0		 1t9wA-1mpxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxi CONSERVED
HYPOTHETICAL PROTEIN
VC0424

(Vibrio cholerae) 		PF06877
(RraB) 		4 MET A  63
PHE A  65
ASN A 106
GLU A  99
 None
 1.37A 1t9wA-1nxiA:
3.9		 1t9wA-1nxiA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omo ALANINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF02423
(OCD_Mu_crystall) 		4 GLN A 140
ALA A 117
PHE A 130
ARG A 145
 GLN  A 140 ( 0.6A)
ALA  A 117 ( 0.0A)
PHE  A 130 ( 1.3A)
ARG  A 145 ( 0.6A)
 1.22A 1t9wA-1omoA:
undetectable		 1t9wA-1omoA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA

(Escherichia
coli) 		no annotation 4 ALA A 156
PHE A  68
ASN A  72
GLU A  76
 None
 1.21A 1t9wA-1onsA:
undetectable		 1t9wA-1onsA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t61 TYPE IV COLLAGEN

(Bos taurus) 		PF01413
(C4) 		4 GLN A  37
PHE A  62
ARG A  76
GLU A  40
 None
 1.15A 1t9wA-1t61A:
undetectable		 1t9wA-1t61A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tq4 INTERFERON-INDUCIBLE
GTPASE

(Mus musculus) 		PF05049
(IIGP) 		4 ALA A 289
PHE A  20
ARG A  45
ASN A  55
 None
 1.28A 1t9wA-1tq4A:
undetectable		 1t9wA-1tq4A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		4 ALA A 184
PHE A  52
ASN A 213
GLU A 219
 None
 1.30A 1t9wA-1v72A:
undetectable		 1t9wA-1v72A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)

(Mus musculus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 GLN B 381
ALA B 435
PHE B 514
GLU B 346
 None
 1.39A 1t9wA-1vkxB:
undetectable		 1t9wA-1vkxB:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0h HYPOTHETICAL PROTEIN
RV0793

(Mycobacterium
tuberculosis) 		PF03992
(ABM) 		4 ALA A  28
PHE A  12
ARG A  78
ASN A  76
 None
None
ACT  A 303 (-4.2A)
None
 1.20A 1t9wA-1y0hA:
3.7		 1t9wA-1y0hA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		4 MET A 304
ALA A 278
PHE A 308
GLU A 151
 None
 1.28A 1t9wA-1zbrA:
undetectable		 1t9wA-1zbrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE

(Oryctolagus
cuniculus) 		PF03071
(GNT-I) 		4 ALA A 416
PHE A 360
ASN A 246
GLU A 309
 None
 1.40A 1t9wA-2am4A:
undetectable		 1t9wA-2am4A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		4 GLN X 466
ALA X 500
ARG X 460
GLU X 462
 None
None
SO4  X 743 ( 3.1A)
None
 1.32A 1t9wA-2epkX:
undetectable		 1t9wA-2epkX:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiu CONSERVED
HYPOTHETICAL PROTEIN

(Agrobacterium
fabrum) 		PF07045
(DUF1330) 		4 ALA A  50
ARG A  81
ASN A  54
GLU A  88
 None
 1.37A 1t9wA-2fiuA:
2.3		 1t9wA-2fiuA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy5 ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF10430
(Ig_Tie2_1) 		4 MET A 116
GLN A  67
ALA A  63
PHE A 203
 None
 1.21A 1t9wA-2gy5A:
undetectable		 1t9wA-2gy5A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 MET A 257
PHE A 271
ASN A 193
GLU A 265
 None
 1.38A 1t9wA-2hpiA:
2.1		 1t9wA-2hpiA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8e UPF0339 PROTEIN YEGP

(Escherichia
coli) 		PF07411
(DUF1508) 		4 ALA A  88
PHE A  33
ARG A  63
ASN A  65
 None
 1.32A 1t9wA-2k8eA:
undetectable		 1t9wA-2k8eA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kmg KLCA

(Bordetella
pertussis) 		PF03230
(Antirestrict) 		4 GLN A 103
ALA A  40
ARG A  33
GLU A 107
 None
 1.37A 1t9wA-2kmgA:
2.1		 1t9wA-2kmgA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vh1 CELL DIVISION
PROTEIN FTSQ

(Escherichia
coli) 		PF03799
(FtsQ)
PF08478
(POTRA_1) 		4 ALA A 167
PHE A 145
ARG A 131
ASN A 133
 None
 1.21A 1t9wA-2vh1A:
undetectable		 1t9wA-2vh1A:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 MET A 474
GLN A 470
ALA A 703
ARG A  94
 None
MGD  A1765 (-3.8A)
None
None
 1.24A 1t9wA-2vpwA:
undetectable		 1t9wA-2vpwA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		4 GLN A  73
ALA A  86
PHE A  58
GLU A 170
 None
None
None
MN  A1005 ( 4.9A)
 1.12A 1t9wA-2vqaA:
undetectable		 1t9wA-2vqaA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Methanothermobacter
thermautotrophicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 GLN A 235
ALA A 233
PHE A 151
GLU B 100
 None
 1.05A 1t9wA-2wnrA:
undetectable		 1t9wA-2wnrA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b13 DEDICATOR OF
CYTOKINESIS PROTEIN
2

(Homo sapiens) 		PF06920
(DHR-2) 		4 GLN A1440
ALA A1472
PHE A1442
ARG A1364
 None
 1.13A 1t9wA-3b13A:
undetectable		 1t9wA-3b13A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bba INTERPAIN A

(Prevotella
intermedia) 		PF01640
(Peptidase_C10) 		4 MET A 224
GLN A 134
ALA A 158
ASN A 321
 None
 1.32A 1t9wA-3bbaA:
undetectable		 1t9wA-3bbaA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLN A 180
ALA A 423
ARG A 178
GLU A 179
 SO4  A 511 (-4.3A)
None
None
SO4  A 511 (-2.5A)
 1.16A 1t9wA-3cnjA:
undetectable		 1t9wA-3cnjA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csz MORPHOGENESIS
PROTEIN 1

(Bacillus virus
phi29) 		no annotation 4 GLN A 106
PHE A 132
ASN A 104
GLU A 100
 NAG  A 202 (-3.3A)
None
None
None
 1.37A 1t9wA-3cszA:
undetectable		 1t9wA-3cszA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cz5 TWO-COMPONENT
RESPONSE REGULATOR,
LUXR FAMILY

(Aurantimonas
manganoxydans) 		PF00072
(Response_reg) 		4 MET A 129
ALA A  94
ARG A 141
GLU A 140
 None
 1.26A 1t9wA-3cz5A:
undetectable		 1t9wA-3cz5A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
hyorhinis) 		PF06646
(Mycoplasma_p37) 		4 MET A 332
ALA A 305
PHE A 324
GLU A 308
 None
None
None
TPP  A 551 ( 4.9A)
 1.25A 1t9wA-3e79A:
undetectable		 1t9wA-3e79A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g65 CHECKPOINT PROTEIN
HUS1

(Homo sapiens) 		PF04005
(Hus1) 		4 MET C  69
GLN C  60
PHE C   3
ASN C  40
 None
 1.12A 1t9wA-3g65C:
undetectable		 1t9wA-3g65C:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htv D-ALLOSE KINASE

(Escherichia
coli) 		PF00480
(ROK) 		4 MET A 249
ALA A 137
ARG A 228
GLU A 185
 None
 1.14A 1t9wA-3htvA:
undetectable		 1t9wA-3htvA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwc CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 2

(Burkholderia
cepacia) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 MET A3377
GLN A3373
ARG A3438
GLU A3443
 None
 1.33A 1t9wA-3hwcA:
2.5		 1t9wA-3hwcA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Bacillus
cytotoxicus) 		PF13377
(Peripla_BP_3) 		4 MET A 197
PHE A 136
ARG A 147
ASN A 115
 None
None
None
MAL  A 501 (-3.1A)
 1.17A 1t9wA-3k4hA:
undetectable		 1t9wA-3k4hA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn3 PUTATIVE PERIPLASMIC
PROTEIN

(Wolinella
succinogenes) 		PF12849
(PBP_like_2) 		4 MET A  79
GLN A 231
ALA A 235
GLU A 228
 None
 1.32A 1t9wA-3kn3A:
undetectable		 1t9wA-3kn3A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		4 GLN A 477
ALA A 611
PHE A 296
GLU A 482
 None
 1.25A 1t9wA-3lvvA:
3.6		 1t9wA-3lvvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		4 ALA A 512
ARG A 356
ASN A 358
GLU A 363
 None
 1.36A 1t9wA-3m62A:
2.6		 1t9wA-3m62A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		4 GLN A 160
ALA A 162
PHE A 108
ARG A 181
 None
 1.22A 1t9wA-3m8yA:
undetectable		 1t9wA-3m8yA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		4 ALA A 288
PHE A 256
ARG A 224
ASN A 251
 None
 1.38A 1t9wA-3mwgA:
undetectable		 1t9wA-3mwgA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzi ACTIVATOR OF
PHOTOPIGMENT AND PUC
EXPRESSION

(Synechocystis
sp. PCC 6803) 		PF04940
(BLUF) 		4 GLN A  58
ALA A  34
ASN A  31
GLU A  61
 None
None
FMN  A 154 (-3.2A)
None
 1.39A 1t9wA-3mziA:
3.2		 1t9wA-3mziA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE

(Sphingosinicella
xenopeptidilytica) 		PF03576
(Peptidase_S58) 		4 MET A 269
GLN A 265
ALA A 259
PHE A 325
 None
 1.29A 1t9wA-3nfbA:
undetectable		 1t9wA-3nfbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obf PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY

(Paenarthrobacter
aurescens) 		PF01614
(IclR) 		4 ALA A 262
ARG A 132
ASN A 127
GLU A 163
 None
 1.34A 1t9wA-3obfA:
undetectable		 1t9wA-3obfA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 MET A 414
ARG A 508
ASN A 826
GLU A 592
 EDO  A 921 (-3.6A)
None
EDO  A 921 (-3.3A)
None
 1.38A 1t9wA-3p5pA:
4.4		 1t9wA-3p5pA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q64 MLL3774 PROTEIN

(Mesorhizobium
loti) 		PF08327
(AHSA1) 		4 MET A  51
ALA A  75
PHE A  53
ARG A  85
 None
 1.40A 1t9wA-3q64A:
undetectable		 1t9wA-3q64A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
anthracis) 		PF00275
(EPSP_synthase) 		4 MET A  92
GLN A  97
ASN A  23
GLU A 169
 None
 1.28A 1t9wA-3sg1A:
undetectable		 1t9wA-3sg1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		4 GLN A 429
PHE A 396
ASN A 434
GLU A 457
 None
 1.38A 1t9wA-3sggA:
undetectable		 1t9wA-3sggA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(uncultured
archaeon) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 GLN B 205
ALA C  65
ARG B 200
GLU B 423
 None
 1.31A 1t9wA-3sqgB:
1.4		 1t9wA-3sqgB:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H

(Escherichia
coli) 		PF01795
(Methyltransf_5) 		4 ALA A 137
PHE A 205
ASN A 172
GLU A 182
 None
 1.25A 1t9wA-3tkaA:
undetectable		 1t9wA-3tkaA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans) 		PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set) 		4 ALA A 505
PHE A 482
ARG A 553
ASN A 556
 None
 1.11A 1t9wA-3utoA:
2.8		 1t9wA-3utoA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v78 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
DEOR-FAMILY)

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 GLN A  17
ALA A  64
ARG A  15
ASN A  56
 None
 1.25A 1t9wA-3v78A:
undetectable		 1t9wA-3v78A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 GLN A 522
PHE A 478
ARG A 518
GLU A 525
 None
 1.31A 1t9wA-3zq4A:
undetectable		 1t9wA-3zq4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apf CULLIN 3

(Homo sapiens) 		PF00888
(Cullin) 		4 MET B 212
PHE B 209
ARG B 180
GLU B 243
 None
 1.27A 1t9wA-4apfB:
3.2		 1t9wA-4apfB:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awd BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 4 ALA A 128
PHE A 148
ARG A 312
ASN A  48
 None
 1.20A 1t9wA-4awdA:
undetectable		 1t9wA-4awdA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE

(Roseobacter
denitrificans) 		PF00557
(Peptidase_M24) 		4 MET A 229
ALA A 249
ARG A 284
ASN A 245
 None
 1.22A 1t9wA-4b28A:
undetectable		 1t9wA-4b28A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cjx C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC,
PUTATIVE

(Trypanosoma
brucei) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 GLN A 132
ALA A 141
ARG A 136
ASN A 139
 None
 1.23A 1t9wA-4cjxA:
undetectable		 1t9wA-4cjxA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLN A 369
ALA A 504
PHE A 459
ARG A 518
 None
None
None
SO4  A1556 (-3.9A)
 1.37A 1t9wA-4cokA:
undetectable		 1t9wA-4cokA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g76 PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF14859
(Colicin_M) 		4 ALA A 113
PHE A  17
ARG A 106
ASN A  98
 None
 1.18A 1t9wA-4g76A:
undetectable		 1t9wA-4g76A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 MET M 132
ALA M  99
ARG M 331
GLU M  92
 None
 1.04A 1t9wA-4heaM:
undetectable		 1t9wA-4heaM:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		4 MET A 526
ALA A 485
PHE A 522
ASN A 497
 None
 1.39A 1t9wA-4i3hA:
4.2		 1t9wA-4i3hA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 ALA A 292
PHE A 311
ARG A 211
ASN A 169
 None
 1.19A 1t9wA-4ic6A:
undetectable		 1t9wA-4ic6A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
cruzi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ALA A 118
PHE A 106
ARG A  84
ASN A  88
 None
 1.27A 1t9wA-4lsmA:
2.6		 1t9wA-4lsmA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		4 GLN A 169
ALA A 171
PHE A 115
ARG A 190
 SO4  A 503 (-3.0A)
None
None
None
 1.27A 1t9wA-4n7tA:
undetectable		 1t9wA-4n7tA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omg GERANYLGERANYL
DIPHOSPHATE CYCLASE

(Streptomyces
melanosporofaciens) 		no annotation 4 GLN A 125
ALA A  63
PHE A 122
ASN A  59
 None
 1.32A 1t9wA-4omgA:
2.9		 1t9wA-4omgA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ony EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 5

(Brucella
melitensis) 		PF00496
(SBP_bac_5) 		4 MET A  88
ALA A  18
ARG A 537
GLU A  94
 None
 1.33A 1t9wA-4onyA:
undetectable		 1t9wA-4onyA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB) 		4 MET A  43
PHE A  58
ASN A  80
GLU A  34
 None
 1.33A 1t9wA-4p6vA:
undetectable		 1t9wA-4p6vA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8r GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ALA A 112
PHE A 100
ARG A  78
ASN A  82
 None
 1.26A 1t9wA-4p8rA:
2.7		 1t9wA-4p8rA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5f GLUTATHIONE
S-TRANSFERASE 1

(Ascaris suum) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ALA A  25
PHE A  29
ARG A 201
ASN A 193
 None
 1.34A 1t9wA-4q5fA:
undetectable		 1t9wA-4q5fA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkm MCCA

(Wolinella
succinogenes) 		no annotation 4 GLN A 296
ALA A 286
PHE A 212
GLU A  96
 None
None
HEM  A 807 (-4.7A)
None
 1.27A 1t9wA-4rkmA:
3.7		 1t9wA-4rkmA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uup MALATE DEHYDROGENASE

(synthetic
construct) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ALA A 105
ARG A  97
ASN A 135
GLU A 323
 None
PO4  A 346 (-3.5A)
None
None
 1.15A 1t9wA-4uupA:
undetectable		 1t9wA-4uupA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		4 GLN A 298
ALA A 343
ASN A  64
GLU A 296
 None
 1.32A 1t9wA-4wgxA:
undetectable		 1t9wA-4wgxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)

(Clostridium
acetobutylicum) 		PF07470
(Glyco_hydro_88) 		4 MET A  54
PHE A  57
ASN A  78
GLU A  26
 None
 1.23A 1t9wA-4wu0A:
undetectable		 1t9wA-4wu0A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xx6 BETA-XYLANASE

(Gloeophyllum
trabeum) 		PF00331
(Glyco_hydro_10) 		4 GLN A 343
ALA A 347
ARG A 284
ASN A 291
 None
 1.38A 1t9wA-4xx6A:
undetectable		 1t9wA-4xx6A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9r OMEGA-3
POLYUNSATURATED
FATTY ACID SYNTHASE
SUBUNIT PFAD

(Shewanella
oneidensis) 		PF03060
(NMO) 		4 ALA A 511
ARG A 351
ASN A 338
GLU A 343
 None
 0.97A 1t9wA-4z9rA:
undetectable		 1t9wA-4z9rA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		4 ALA A 147
PHE A 152
ARG A  40
ASN A  88
 IOD  A 304 (-4.7A)
None
IOD  A 305 (-4.4A)
IOD  A 304 (-4.0A)
 1.35A 1t9wA-4zu2A:
3.1		 1t9wA-4zu2A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1r 7S VICILIN

(Carya
illinoinensis) 		PF00190
(Cupin_1) 		4 MET A 627
ALA A 619
PHE A 726
ASN A 617
 MPD  A 802 (-4.0A)
MPD  A 802 (-3.6A)
None
MPD  A 802 (-3.5A)
 1.34A 1t9wA-5e1rA:
undetectable		 1t9wA-5e1rA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLN A 673
ALA A 878
ARG A 619
ASN A 913
 None
 1.38A 1t9wA-5epgA:
undetectable		 1t9wA-5epgA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ALA A 509
PHE A 212
ARG A 236
ASN A 226
 None
 1.27A 1t9wA-5f7cA:
2.4		 1t9wA-5f7cA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		4 MET A 392
PHE A 399
ARG A 292
ASN A 294
 None
 1.00A 1t9wA-5fjnA:
undetectable		 1t9wA-5fjnA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mt2 BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLN A 205
ALA A 245
ARG A 241
ASN A 259
 None
 1.11A 1t9wA-5mt2A:
undetectable		 1t9wA-5mt2A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mua RICIN B-RELATED
LECTIN

(Polyporus
squamosus) 		PF14200
(RicinB_lectin_2) 		4 GLN A 268
ALA A 249
PHE A 206
ASN A 251
 E64  A 304 ( 4.9A)
E64  A 304 ( 4.3A)
None
None
 1.37A 1t9wA-5muaA:
undetectable		 1t9wA-5muaA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 4 ALA A 329
PHE A 185
ASN A 301
GLU A 344
 None
 0.99A 1t9wA-5n6vA:
undetectable		 1t9wA-5n6vA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER

(Proteus
mirabilis) 		no annotation 4 ALA A  35
ARG A 362
ASN A 356
GLU A 110
 None
 1.23A 1t9wA-5nvaA:
undetectable		 1t9wA-5nvaA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3b GLYCOSIDE HYDROLASE

(Bacteroides
plebeius) 		no annotation 4 PHE A 263
ARG A 241
ASN A 322
GLU A 279
 None
None
EDO  A 510 (-4.6A)
EDO  A 510 ( 4.0A)
 1.28A 1t9wA-5t3bA:
undetectable		 1t9wA-5t3bA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Burkholderia
vietnamiensis) 		PF00982
(Glyco_transf_20) 		4 MET A 282
GLN A 290
PHE A 279
ARG A 257
 None
 1.25A 1t9wA-5tvgA:
undetectable		 1t9wA-5tvgA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue2 MATRILYSIN

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 GLN A  63
ALA A   4
ARG A  57
ASN A  55
 None
 1.07A 1t9wA-5ue2A:
undetectable		 1t9wA-5ue2A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukb ANTI-VESICULAR
STOMATITIS VIRUS N
VHH

(Vicugna pacos) 		no annotation 4 ALA d  61
PHE d  37
ARG d  33
ASN d  59
 None
 1.21A 1t9wA-5ukbd:
undetectable		 1t9wA-5ukbd:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 MET A 119
ALA A 206
PHE A 258
ARG A 267
 None
 1.39A 1t9wA-5vpuA:
undetectable		 1t9wA-5vpuA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsg PRE-MRNA-SPLICING
FACTOR
CEF1,PRE-MRNA-SPLICI
NG FACTOR
CEF1,CEF1,PRE-MRNA-S
PLICING FACTOR CEF1

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		4 GLN c  96
ALA c  88
PHE c  62
GLU c  54
 None
 1.36A 1t9wA-5wsgc:
undetectable		 1t9wA-5wsgc:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf UNCONVENTIONAL
MYOSIN-VIIB

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		4 ALA A2029
ARG A1892
ASN A2031
GLU A1915
 None
 1.34A 1t9wA-5xbfA:
undetectable		 1t9wA-5xbfA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22

(Homo sapiens) 		no annotation 4 MET A 366
ALA A 266
PHE A 360
ARG A 256
 None
 1.26A 1t9wA-5y31A:
undetectable		 1t9wA-5y31A:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 ALA C2796
ARG C2538
ASN C2560
GLU C2564
 None
 1.28A 1t9wA-5y3rC:
undetectable		 1t9wA-5y3rC:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ylz PRE-MRNA-SPLICING
FACTOR CEF1

(Saccharomyces
cerevisiae) 		no annotation 4 GLN J  96
ALA J  88
PHE J  62
GLU J  54
 None
 1.36A 1t9wA-5ylzJ:
undetectable		 1t9wA-5ylzJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 4 ALA A 425
PHE A 376
ARG A 488
GLU A 441
 None
 1.14A 1t9wA-6bfiA:
undetectable		 1t9wA-6bfiA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP40

(Homo sapiens) 		no annotation 4 GLN G 264
ALA G 256
ARG G 271
ASN G 252
 None
 1.12A 1t9wA-6d6qG:
undetectable		 1t9wA-6d6qG:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens) 		no annotation 4 MET A 289
PHE A 393
ARG A 444
ASN A 383
 None
 0.99A 1t9wA-6eo5A:
1.7		 1t9wA-6eo5A:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 GLN A 196
ALA A 107
PHE A 115
GLU A 153
 None
 1.02A 1t9wA-6etzA:
undetectable		 1t9wA-6etzA:
5.53