SIMILAR PATTERNS OF AMINO ACIDS FOR 1T9U_A_CPFA5002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 PHE A 429
PHE A 430
ASN A 406
GLN A 438
 None
 1.13A 1t9uA-1csjA:
5.2		 1t9uA-1csjA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 ASN C 415
ARG C 746
ASN C 742
GLN C 749
 None
 1.41A 1t9uA-1h2tC:
2.7		 1t9uA-1h2tC:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE

(Pseudomonas sp.
KKS102) 		PF00903
(Glyoxalase) 		4 PHE B 136
ASN B 215
ARG B 192
GLN B 141
 None
 1.34A 1t9uA-1kwcB:
0.0		 1t9uA-1kwcB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phj TELOMERE-BINDING
PROTEIN BETA SUBUNIT

(Sterkiella nova) 		PF07404
(TEBP_beta) 		4 PHE B  71
PHE B  63
ASN B  79
GLN B 221
 None
 1.28A 1t9uA-1phjB:
0.0		 1t9uA-1phjB:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcj POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
americana) 		PF00161
(RIP) 		4 PHE A  90
ASN A  91
ARG A  67
ASN A  70
 APT  A 901 ( 4.7A)
None
None
None
 1.37A 1t9uA-1qcjA:
0.0		 1t9uA-1qcjA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t77 LIPOPOLYSACCHARIDE-R
ESPONSIVE AND
BEIGE-LIKE ANCHOR
PROTEIN

(Homo sapiens) 		PF02138
(Beach)
PF14844
(PH_BEACH) 		4 PHE A2228
ASN A2222
ASN A2210
GLN A2216
 None
 1.44A 1t9uA-1t77A:
0.0		 1t9uA-1t77A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm9 PLAKOPHILIN 1

(Homo sapiens) 		PF00514
(Arm) 		4 PHE A 404
ARG A 312
ASN A 356
GLN A 349
 None
 1.25A 1t9uA-1xm9A:
0.0		 1t9uA-1xm9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqi CALPAIN-1 CATALYTIC
SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		4 PHE A  97
PHE A 186
ASN A 184
GLN A 142
 None
 1.48A 1t9uA-2nqiA:
0.0		 1t9uA-2nqiA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p22 PROTEIN SRN2
SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE

(Saccharomyces
cerevisiae) 		PF07200
(Mod_r)
PF09454
(Vps23_core) 		4 ASN A 326
ARG C 198
ASN C 157
GLN C 194
 None
 1.44A 1t9uA-2p22A:
3.4		 1t9uA-2p22A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4

(Phytolacca
dioica) 		PF00161
(RIP) 		4 PHE A  89
ASN A  90
ARG A  67
ASN A  70
 ADE  A 501 ( 4.9A)
None
None
None
 1.36A 1t9uA-2qesA:
0.0		 1t9uA-2qesA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpq PROTEIN BUG27

(Bordetella
pertussis) 		PF03401
(TctC) 		4 PHE A  75
ASN A  78
ASN A  98
GLN A 228
 None
None
None
CIT  A 302 (-2.9A)
 1.36A 1t9uA-2qpqA:
1.7		 1t9uA-2qpqA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		4 PHE A 208
PHE A 229
ASN A 226
ASN A 536
 None
 1.29A 1t9uA-2vsaA:
undetectable		 1t9uA-2vsaA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8x TLR1789 PROTEIN

(Thermosynechococcus
elongatus) 		PF07244
(POTRA)
PF08479
(POTRA_2) 		4 PHE X 119
PHE X 114
ASN X 111
ASN X 174
 None
 1.42A 1t9uA-2x8xX:
undetectable		 1t9uA-2x8xX:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		4 PHE A 193
ASN A 194
ARG A 180
GLN A 215
 None
None
EB4  A1300 (-2.8A)
EB4  A1300 (-3.5A)
 1.27A 1t9uA-2xuzA:
undetectable		 1t9uA-2xuzA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		4 PHE A 324
ASN A  89
ARG A 181
ASN A 183
 None
 1.45A 1t9uA-2z00A:
undetectable		 1t9uA-2z00A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634

(Shewanella
baltica) 		PF13640
(2OG-FeII_Oxy_3) 		4 PHE A  93
ASN A  85
ARG A 102
ASN A  99
 IMD  A 502 (-4.0A)
None
IMD  A 501 ( 4.7A)
None
 1.45A 1t9uA-3dkqA:
undetectable		 1t9uA-3dkqA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff2 UNCHARACTERIZED
CYSTATIN FOLD
PROTEIN
(YP_497570.1) FROM
NTF2 SUPERFAMILY

(Novosphingobium
aromaticivorans) 		PF12680
(SnoaL_2) 		4 PHE A 114
ASN A  34
ARG A  83
ASN A  61
 None
None
ACT  A 117 (-3.0A)
ACT  A 117 ( 4.8A)
 1.31A 1t9uA-3ff2A:
undetectable		 1t9uA-3ff2A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr1 PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Histophilus
somni) 		PF03881
(Fructosamin_kin) 		4 PHE A 107
ASN A 235
ASN A  73
GLN A 202
 None
 1.20A 1t9uA-3jr1A:
undetectable		 1t9uA-3jr1A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3f PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL)
PF09070
(PFU) 		4 PHE X 580
ASN X 581
ASN X 676
GLN X 471
 None
 1.46A 1t9uA-3l3fX:
undetectable		 1t9uA-3l3fX:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		4 PHE A 198
ASN A 200
ARG A 113
ASN A  85
 None
 1.45A 1t9uA-3n71A:
undetectable		 1t9uA-3n71A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgh RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 PHE A 429
PHE A 430
ASN A 406
GLN A 438
 None
 1.21A 1t9uA-3qghA:
4.4		 1t9uA-3qghA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 PHE A1094
ASN A1136
ASN A 474
GLN A1048
 CYG  A1135 ( 3.1A)
CYG  A1135 ( 4.4A)
None
None
 1.21A 1t9uA-3ummA:
5.0		 1t9uA-3ummA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 PHE A 144
PHE A 102
ASN A 105
ASN A 157
 None
None
None
UDP  A 501 (-2.7A)
 1.46A 1t9uA-4dshA:
2.4		 1t9uA-4dshA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1s POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 PHE A 314
PHE A 360
ASN A 361
ARG A 345
 None
 1.38A 1t9uA-4j1sA:
undetectable		 1t9uA-4j1sA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 PHE A1964
ASN A1971
ASN A1943
GLN A1959
 None
 1.15A 1t9uA-4o9xA:
undetectable		 1t9uA-4o9xA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		4 PHE A 369
PHE A 396
ASN A 397
ASN A 362
 None
 1.42A 1t9uA-4qbuA:
2.9		 1t9uA-4qbuA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfw ACYL-COA
THIOESTERASE II

(Yersinia pestis) 		PF13622
(4HBT_3) 		4 PHE A 165
ARG A 178
ASN A 206
GLN A 213
 None
 1.37A 1t9uA-4qfwA:
undetectable		 1t9uA-4qfwA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 PHE A 306
PHE A 311
ASN A 312
GLN A 238
 None
 1.20A 1t9uA-4r4zA:
undetectable		 1t9uA-4r4zA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 PHE A 311
ASN A 312
ASN A 352
GLN A 238
 None
 1.35A 1t9uA-4r4zA:
undetectable		 1t9uA-4r4zA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 PHE A 115
PHE A 245
ASN A 214
ASN A 234
 None
 1.42A 1t9uA-4r6lA:
undetectable		 1t9uA-4r6lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 PHE A 559
ASN A 603
ARG A 525
ASN A 526
 None
 1.46A 1t9uA-4xi2A:
undetectable		 1t9uA-4xi2A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		4 ASN A 127
ARG A 342
ASN A 344
GLN A 363
 None
 1.44A 1t9uA-4zgvA:
undetectable		 1t9uA-4zgvA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 PHE A 690
PHE A 687
ASN A 652
GLN A 724
 None
 1.50A 1t9uA-4zr5A:
2.8		 1t9uA-4zr5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8

(Shigella
flexneri) 		PF12468
(TTSSLRR) 		4 PHE A 187
PHE A 188
ASN A 191
ASN A 161
 None
 1.47A 1t9uA-5b0nA:
undetectable		 1t9uA-5b0nA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Enterovirus D) 		PF00073
(Rhv) 		4 PHE B 200
ASN A 212
ASN B  87
GLN B 206
 None
 1.44A 1t9uA-5bnnB:
undetectable		 1t9uA-5bnnB:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4o CAPSID PROTEIN VP1

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 PHE A 242
ASN A 239
ASN A 445
GLN A 402
 None
None
None
EDO  A 602 (-3.9A)
 1.41A 1t9uA-5f4oA:
undetectable		 1t9uA-5f4oA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 PHE A 632
PHE A 641
ASN A 642
ASN A 792
 None
 1.45A 1t9uA-5fjjA:
undetectable		 1t9uA-5fjjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 4 PHE A 520
ARG A 531
ASN A 575
GLN A 527
 None
 1.38A 1t9uA-5h3kA:
undetectable		 1t9uA-5h3kA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		4 PHE A 143
ASN A 201
ASN A 152
GLN A 146
 None
 1.23A 1t9uA-5karA:
undetectable		 1t9uA-5karA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 4 PHE A 306
ASN A 197
ARG A 313
GLN A 252
 C  B   7 ( 3.4A)
None
C  B   7 ( 4.1A)
None
 1.47A 1t9uA-5kk5A:
undetectable		 1t9uA-5kk5A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASN Q 329
ARG Q 445
ASN Q 183
GLN Q 401
 None
 1.44A 1t9uA-5lcwQ:
undetectable		 1t9uA-5lcwQ:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASN R 329
ARG R 445
ASN R 183
GLN R 401
 None
 1.44A 1t9uA-5lcwR:
undetectable		 1t9uA-5lcwR:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus) 		no annotation 4 PHE A 382
ASN A 377
ASN A 396
GLN A 404
 None
 1.19A 1t9uA-5yemA:
undetectable		 1t9uA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 PHE A 330
ASN A 362
ASN A 300
GLN A 305
 None
None
NAG  A 904 (-2.0A)
NAG  A 908 (-3.2A)
 1.46A 1t9uA-5zlnA:
undetectable		 1t9uA-5zlnA:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cpy GRMZM2G135359
PSEUDOKINASE

(Zea mays) 		no annotation 4 PHE A 377
ASN A 268
ARG A 355
ASN A 356
 None
 1.39A 1t9uA-6cpyA:
undetectable		 1t9uA-6cpyA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 4 PHE A 136
ASN A 135
ASN A 125
GLN A 716
 None
 1.34A 1t9uA-6d6vA:
2.8		 1t9uA-6d6vA:
5.40