SIMILAR PATTERNS OF AMINO ACIDS FOR 1T88_B_CAMB2422

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.19A 1t88B-1d6hA:
undetectable		 1t88B-1d6hA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij5 PLASMODIAL SPECIFIC
LAV1-2 PROTEIN

(Physarum
polycephalum) 		PF13202
(EF-hand_5) 		4 PHE A 344
LEU A 311
VAL A 310
VAL A 286
 None
 1.16A 1t88B-1ij5A:
0.0		 1t88B-1ij5A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfp HYPOTHETICAL PROTEIN
AQ_1575

(Aquifex
aeolicus) 		PF01709
(Transcrip_reg) 		4 PHE A 117
LEU A 222
VAL A 234
VAL A 130
 None
 0.89A 1t88B-1lfpA:
0.0		 1t88B-1lfpA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 TYR A 278
LEU A  19
VAL A 300
VAL A 266
 None
 1.20A 1t88B-1pweA:
0.0		 1t88B-1pweA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7h YKOF

(Bacillus
subtilis) 		PF07615
(Ykof) 		4 PHE A  59
LEU A 187
VAL A 185
VAL A 170
 None
 1.14A 1t88B-1s7hA:
0.0		 1t88B-1s7hA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		4 PHE A 564
LEU A 560
VAL A 449
VAL A 783
 None
 1.16A 1t88B-1taqA:
0.0		 1t88B-1taqA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tw9 GLUTATHIONE
S-TRANSFERASE 2

(Heligmosomoides
polygyrus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 PHE A 132
LEU A 148
VAL A 156
VAL A 164
 None
 1.19A 1t88B-1tw9A:
0.0		 1t88B-1tw9A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wk4 TTK003001606

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		4 PHE A 139
TYR A 140
LEU A  91
VAL A  96
 MES  A 201 ( 4.3A)
None
None
MES  A 201 ( 4.4A)
 1.20A 1t88B-1wk4A:
0.0		 1t88B-1wk4A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.09A 1t88B-1wytA:
0.0		 1t88B-1wytA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 PHE A 415
LEU A 393
VAL A 389
VAL A 366
 None
 1.22A 1t88B-1wytA:
0.0		 1t88B-1wytA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys9 PROTEIN SPY1043

(Streptococcus
pyogenes) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 PHE A  27
LEU A 246
VAL A 225
VAL A 202
 None
 1.12A 1t88B-1ys9A:
undetectable		 1t88B-1ys9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		4 TYR A  93
LEU A 150
VAL A 138
VAL A  81
 SAZ  A 709 (-4.9A)
None
None
None
 0.94A 1t88B-1yyrA:
undetectable		 1t88B-1yyrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aco OUTER MEMBRANE
LIPOPROTEIN BLC

(Escherichia
coli) 		PF08212
(Lipocalin_2) 		4 TYR A  39
LEU A 141
VAL A 130
VAL A 106
 None
 1.05A 1t88B-2acoA:
undetectable		 1t88B-2acoA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajh LEUCYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF13603
(tRNA-synt_1_2) 		4 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.06A 1t88B-2ajhA:
undetectable		 1t88B-2ajhA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.94A 1t88B-2awaA:
undetectable		 1t88B-2awaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 PHE A 205
TYR A 181
LEU A  35
VAL A  50
 None
 1.13A 1t88B-2bg9A:
undetectable		 1t88B-2bg9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		4 PHE A 120
TYR A 218
LEU A 159
VAL A 162
 None
 1.16A 1t88B-2c7bA:
undetectable		 1t88B-2c7bA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgk GLUTAMATE
DECARBOXYLASE BETA

(Escherichia
coli) 		PF00282
(Pyridoxal_deC) 		4 PHE A 380
TYR A 363
LEU A 360
VAL A 406
 None
 1.22A 1t88B-2dgkA:
undetectable		 1t88B-2dgkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgk GLUTAMATE
DECARBOXYLASE BETA

(Escherichia
coli) 		PF00282
(Pyridoxal_deC) 		4 PHE A 380
TYR A 363
LEU A 445
VAL A 406
 None
 1.08A 1t88B-2dgkA:
undetectable		 1t88B-2dgkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzr APOLIPOPROTEIN D

(Homo sapiens) 		PF08212
(Lipocalin_2) 		4 TYR A  22
LEU A 129
VAL A 111
VAL A  87
 None
 1.12A 1t88B-2hzrA:
undetectable		 1t88B-2hzrA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 PHE A 150
LEU A 163
VAL A 166
VAL A 176
 None
 1.20A 1t88B-2i80A:
undetectable		 1t88B-2i80A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Methanothermobacter
thermautotrophicus) 		PF01641
(SelR) 		4 PHE A  90
LEU A 123
VAL A 114
VAL A  94
 None
 0.98A 1t88B-2k8dA:
undetectable		 1t88B-2k8dA:
17.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 PHE A  87
TYR A  96
LEU A 244
VAL A 247
VAL A 295
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-4.6A)
 0.13A 1t88B-2m56A:
70.0		 1t88B-2m56A:
99.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 PHE A  87
TYR A  96
LEU A 244
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
None
 0.63A 1t88B-2m56A:
70.0		 1t88B-2m56A:
99.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n67 HEMOLYSIN II

(Bacillus cereus) 		no annotation 4 PHE B  66
TYR B  64
LEU B  36
VAL B  16
 None
 1.12A 1t88B-2n67B:
undetectable		 1t88B-2n67B:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2
HYPOTHETICAL 12.0
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF09454
(Vps23_core)
PF07200
(Mod_r)
PF09452
(Mvb12) 		4 PHE D  71
TYR D  75
LEU C  58
VAL A 232
 None
 1.20A 1t88B-2p22D:
undetectable		 1t88B-2p22D:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5r GLUTATHIONE
PEROXIDASE 5

(Populus
trichocarpa x
Populus
deltoides) 		PF00255
(GSHPx) 		4 PHE A  71
LEU A  35
VAL A  12
VAL A  25
 None
 1.15A 1t88B-2p5rA:
undetectable		 1t88B-2p5rA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2peg HEMOGLOBIN SUBUNIT
BETA

(Trematomus
bernacchii) 		PF00042
(Globin) 		4 PHE B  42
LEU B  96
VAL B  98
VAL B  67
 HEM  B 400 (-4.6A)
HEM  B 400 (-4.2A)
HEM  B 400 ( 4.5A)
HEM  B 400 (-3.7A)
 1.20A 1t88B-2pegB:
undetectable		 1t88B-2pegB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 TYR A 235
LEU A   5
VAL A   3
VAL A  64
 None
 1.20A 1t88B-2w40A:
undetectable		 1t88B-2w40A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy4 SINGLE DOMAIN
HAEMOGLOBIN

(Campylobacter
jejuni) 		PF00042
(Globin) 		4 PHE A  42
TYR A  28
LEU A  56
VAL A  89
 HEM  A 150 ( 3.5A)
CYN  A 151 (-4.7A)
CYN  A 151 (-4.1A)
HEM  A 150 (-3.8A)
 1.08A 1t88B-2wy4A:
undetectable		 1t88B-2wy4A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		4 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.16A 1t88B-2yh2A:
undetectable		 1t88B-2yh2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhp BLEOMYCIN RESISTANCE
PROTEIN

(Streptoalloteichus
hindustanus) 		no annotation 4 PHE A  29
LEU A 108
VAL A 116
VAL A  68
 None
 1.09A 1t88B-2zhpA:
undetectable		 1t88B-2zhpA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		4 PHE A 117
TYR A 210
LEU A 155
VAL A 158
 None
 1.14A 1t88B-3ailA:
undetectable		 1t88B-3ailA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Methylobacillus
flagellatus) 		PF03069
(FmdA_AmdA) 		4 TYR A 227
LEU A 279
VAL A 278
VAL A 223
 None
 0.88A 1t88B-3b9tA:
undetectable		 1t88B-3b9tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9h ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		4 PHE A 146
LEU A 162
VAL A 169
VAL A 223
 None
 1.13A 1t88B-3c9hA:
undetectable		 1t88B-3c9hA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cy5 HEMOGLOBIN SUBUNIT
BETA

(Bubalus bubalis) 		PF00042
(Globin) 		4 PHE B 122
LEU B 110
VAL B 134
VAL B  11
 None
 1.16A 1t88B-3cy5B:
undetectable		 1t88B-3cy5B:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epr HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
agalactiae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 PHE A  29
LEU A 247
VAL A 226
VAL A 203
 None
 1.22A 1t88B-3eprA:
undetectable		 1t88B-3eprA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etu PROTEIN TRANSPORT
PROTEIN DSL1

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		4 PHE A 179
TYR A 167
LEU A 123
VAL A  68
 None
 1.22A 1t88B-3etuA:
undetectable		 1t88B-3etuA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TYR A 145
LEU A  50
VAL A  89
VAL A  81
 None
 1.17A 1t88B-3g5wA:
undetectable		 1t88B-3g5wA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		4 PHE A 302
LEU A  32
VAL A 344
VAL A 389
 None
 1.07A 1t88B-3g8mA:
undetectable		 1t88B-3g8mA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdj HEMOGLOBIN SUBUNIT
BETA

(Camelus
dromedarius) 		PF00042
(Globin) 		4 PHE B 122
LEU B 110
VAL B 134
VAL B  11
 None
 1.18A 1t88B-3gdjB:
undetectable		 1t88B-3gdjB:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		4 PHE A 105
TYR A 447
LEU A 425
VAL A 512
 None
 1.09A 1t88B-3j1cA:
undetectable		 1t88B-3j1cA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyy LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE

(Enterococcus
faecium) 		no annotation 4 PHE A  92
LEU A  14
VAL A  11
VAL A  80
 None
 0.99A 1t88B-3jyyA:
undetectable		 1t88B-3jyyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl2 PUTATIVE
ISOCHORISMATASE

(Streptomyces
avermitilis) 		PF00857
(Isochorismatase) 		4 PHE A 154
LEU A 173
VAL A 196
VAL A 168
 None
 1.14A 1t88B-3kl2A:
undetectable		 1t88B-3kl2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 PHE B 115
TYR B 116
LEU B 196
VAL B 225
 None
 1.20A 1t88B-3lcvB:
undetectable		 1t88B-3lcvB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbt OUTER MEMBRANE
LIPOPROTEIN BLC

(Escherichia
coli) 		PF08212
(Lipocalin_2) 		4 TYR A  21
LEU A 123
VAL A 112
VAL A  88
 None
 1.04A 1t88B-3mbtA:
undetectable		 1t88B-3mbtA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 PHE A1532
LEU A1511
VAL A1498
VAL A1489
 None
None
None
GOL  A   1 ( 4.7A)
 1.01A 1t88B-3pvlA:
undetectable		 1t88B-3pvlA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr9 DIHYDROPTEROATE
SYNTHASE

(Coxiella
burnetii) 		PF00809
(Pterin_bind) 		4 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.86A 1t88B-3tr9A:
undetectable		 1t88B-3tr9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		4 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.03A 1t88B-3ubcA:
undetectable		 1t88B-3ubcA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umf ADENYLATE KINASE

(Schistosoma
mansoni) 		PF00406
(ADK) 		4 PHE A  13
TYR A  96
LEU A  74
VAL A 110
 None
 0.86A 1t88B-3umfA:
undetectable		 1t88B-3umfA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 TYR A1803
LEU A1878
VAL A1815
VAL A1822
 None
 1.22A 1t88B-3vkgA:
undetectable		 1t88B-3vkgA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 PHE A 228
LEU A 167
VAL A 164
VAL A 185
 None
 1.16A 1t88B-4b8jA:
undetectable		 1t88B-4b8jA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 PHE A 205
TYR A 181
LEU A  35
VAL A  50
 None
 1.13A 1t88B-4booA:
undetectable		 1t88B-4booA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 PHE A 228
LEU A 167
VAL A 164
VAL A 185
 None
 1.14A 1t88B-4bplA:
undetectable		 1t88B-4bplA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehc PE-PGRS FAMILY
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 PHE A 153
LEU A  35
VAL A  21
VAL A  79
 None
 1.03A 1t88B-4ehcA:
undetectable		 1t88B-4ehcA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 112
LEU A 281
VAL A 280
VAL A 119
 None
 1.13A 1t88B-4eutA:
undetectable		 1t88B-4eutA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 112
LEU A 281
VAL A 280
VAL A 119
 None
 1.13A 1t88B-4euuA:
undetectable		 1t88B-4euuA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.09A 1t88B-4g1pA:
undetectable		 1t88B-4g1pA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Mycolicibacterium
thermoresistibile) 		PF16113
(ECH_2) 		4 PHE A 172
LEU A 153
VAL A 118
VAL A 129
 None
 1.07A 1t88B-4hdtA:
undetectable		 1t88B-4hdtA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		4 PHE A 112
LEU A 281
VAL A 280
VAL A 119
 None
 1.18A 1t88B-4jlcA:
undetectable		 1t88B-4jlcA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvs ALDEHYDE
DECARBONYLASE

(Prochlorococcus
marinus) 		PF11266
(Ald_deCOase) 		4 TYR A  30
LEU A  87
VAL A  89
VAL A  41
 None
None
None
6NA  A 301 ( 4.2A)
 1.19A 1t88B-4kvsA:
undetectable		 1t88B-4kvsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		4 TYR A 314
LEU A 342
VAL A 350
VAL A 355
 None
 1.12A 1t88B-4n0rA:
undetectable		 1t88B-4n0rA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofq PUTATIVE CELL
SURFACE PROTEIN

(Streptococcus
pyogenes) 		PF16364
(Antigen_C) 		4 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.14A 1t88B-4ofqA:
undetectable		 1t88B-4ofqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE

(Mycobacterium
tuberculosis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 PHE A 153
LEU A  21
VAL A  17
VAL A 164
 None
 1.15A 1t88B-4ol9A:
undetectable		 1t88B-4ol9A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Psychromonas
ingrahamii) 		PF00464
(SHMT) 		4 PHE A 302
LEU A  32
VAL A 344
VAL A 389
 None
 1.19A 1t88B-4p3mA:
undetectable		 1t88B-4p3mA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pav GLYOXALASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF00903
(Glyoxalase) 		4 PHE A 120
LEU A  50
VAL A  48
VAL A  71
 None
 1.13A 1t88B-4pavA:
undetectable		 1t88B-4pavA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puf E3 UBIQUITIN-PROTEIN
LIGASE SLRP

(Salmonella
enterica) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		4 PHE A 663
LEU A 673
VAL A 672
VAL A 756
 None
 1.16A 1t88B-4pufA:
undetectable		 1t88B-4pufA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.07A 1t88B-4rhhA:
undetectable		 1t88B-4rhhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4std SCYTALONE
DEHYDRATASE

(Magnaporthe
grisea) 		PF02982
(Scytalone_dh) 		4 PHE A  53
TYR A  50
VAL A  75
VAL A 108
 None
BFS  A 173 (-4.3A)
BFS  A 173 (-4.5A)
BFS  A 173 ( 4.4A)
 1.03A 1t88B-4stdA:
undetectable		 1t88B-4stdA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.20A 1t88B-4wumA:
undetectable		 1t88B-4wumA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 PHE A 128
TYR A 225
LEU A 169
VAL A 172
 None
 1.11A 1t88B-4wy8A:
undetectable		 1t88B-4wy8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		4 PHE A 163
TYR A 202
VAL A 151
VAL A 117
 None
 0.92A 1t88B-4y96A:
undetectable		 1t88B-4y96A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjy CHALCONE SYNTHASE 1

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 376
LEU A 313
VAL A 316
VAL A 372
 None
 1.18A 1t88B-4yjyA:
undetectable		 1t88B-4yjyA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		4 PHE A 125
TYR A 220
LEU A 164
VAL A 167
 None
 1.12A 1t88B-4ypvA:
undetectable		 1t88B-4ypvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1p CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		4 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.18A 1t88B-4z1pA:
undetectable		 1t88B-4z1pA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z23 CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		4 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.14A 1t88B-4z23A:
undetectable		 1t88B-4z23A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cay ENVELOPE
GLYCOPROTEIN GP120
CORE FROM ST STRAIN
OF HIV-2

(Human
immunodeficiency
virus 2) 		PF00516
(GP120) 		4 PHE G 275
LEU G 409
VAL G 412
VAL G 357
 None
 1.11A 1t88B-5cayG:
undetectable		 1t88B-5cayG:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cay ENVELOPE
GLYCOPROTEIN GP120
CORE FROM ST STRAIN
OF HIV-2

(Human
immunodeficiency
virus 2) 		PF00516
(GP120) 		4 PHE G 482
LEU G 301
VAL G 357
VAL G 412
 None
 0.96A 1t88B-5cayG:
undetectable		 1t88B-5cayG:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj3 ZBM BINDING PROTEIN

(Streptomyces
flavoviridis) 		no annotation 4 PHE A  29
LEU A 108
VAL A 116
VAL A  68
 None
 1.11A 1t88B-5cj3A:
undetectable		 1t88B-5cj3A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5v PRP38

(Chaetomium
thermophilum) 		PF03371
(PRP38) 		4 TYR A 105
LEU A 119
VAL A  65
VAL A  56
 None
 0.98A 1t88B-5f5vA:
undetectable		 1t88B-5f5vA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 PHE A 655
TYR A 656
LEU A 277
VAL A 276
 None
 1.09A 1t88B-5f7sA:
undetectable		 1t88B-5f7sA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gte LACHRYMATORY-FACTOR
SYNTHASE

(Allium cepa) 		PF10604
(Polyketide_cyc2) 		4 PHE A 104
TYR A 114
LEU A 152
VAL A  73
 None
 0.88A 1t88B-5gteA:
undetectable		 1t88B-5gteA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		4 PHE A 719
LEU A 762
VAL A 765
VAL A 744
 None
 1.17A 1t88B-5irmA:
undetectable		 1t88B-5irmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		4 TYR A  17
LEU A  74
VAL A  76
VAL A  28
 None
None
None
OCD  A 500 ( 4.6A)
 1.21A 1t88B-5k52A:
undetectable		 1t88B-5k52A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k53 ALDEHYDE
DEFORMYLATING
OXYGENASE

(Oscillatoria
sp.) 		PF11266
(Ald_deCOase) 		4 TYR A  17
LEU A  74
VAL A  76
VAL A  28
 None
None
None
STE  A 502 ( 4.8A)
 1.07A 1t88B-5k53A:
undetectable		 1t88B-5k53A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kpe DE NOVO BETA SHEET
DESIGN PROTEIN OR664

(synthetic
construct) 		no annotation 4 PHE A  94
LEU A  31
VAL A  39
VAL A 106
 None
 1.00A 1t88B-5kpeA:
undetectable		 1t88B-5kpeA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd MON1
CCZ1

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF03164
(Mon1)
PF08217
(DUF1712) 		4 PHE B 114
LEU A 226
VAL A 287
VAL A 274
 None
 1.00A 1t88B-5lddB:
undetectable		 1t88B-5lddB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy7 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		4 PHE B 176
LEU B 187
VAL B 183
VAL B 318
 None
 1.03A 1t88B-5sy7B:
undetectable		 1t88B-5sy7B:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpj DENOVO NTF2

(synthetic
construct) 		PF12680
(SnoaL_2) 		4 PHE A  89
LEU A  17
VAL A  62
VAL A  76
 None
 1.14A 1t88B-5tpjA:
undetectable		 1t88B-5tpjA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uba RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF00849
(PseudoU_synth_2) 		4 TYR A 185
LEU A 152
VAL A 159
VAL A 181
 None
 1.17A 1t88B-5ubaA:
undetectable		 1t88B-5ubaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE

(Malus domestica) 		no annotation 4 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.16A 1t88B-5uc5A:
undetectable		 1t88B-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE

(Hypericum
androsaemum) 		no annotation 4 TYR A 304
LEU A 321
VAL A 317
VAL A 383
 None
 1.06A 1t88B-5ucoA:
undetectable		 1t88B-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1m U6 SNRNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF09749
(HVSL) 		4 PHE A 151
LEU A 123
VAL A  87
VAL A 175
 None
 1.14A 1t88B-5v1mA:
undetectable		 1t88B-5v1mA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		4 PHE A 301
LEU A  31
VAL A 343
VAL A 388
 None
 1.11A 1t88B-5vmbA:
undetectable		 1t88B-5vmbA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtn REPLICATION
INITIATION AND
MEMBRANE ATTACHMENT
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 4 PHE A 211
LEU A 266
VAL A 229
VAL A 220
 None
 1.12A 1t88B-5wtnA:
undetectable		 1t88B-5wtnA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN

(Homo sapiens) 		no annotation 4 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.10A 1t88B-5yewB:
undetectable		 1t88B-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co0 STYRYLPYRONE
SYNTHASE 1

(Piper
methysticum) 		no annotation 4 PHE A 374
LEU A 311
VAL A 314
VAL A 370
 None
 1.15A 1t88B-6co0A:
undetectable		 1t88B-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B

(Escherichia
coli) 		no annotation 4 PHE A 317
TYR A 316
LEU A 287
VAL A 283
 None
 1.22A 1t88B-6ei9A:
undetectable		 1t88B-6ei9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 4 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.05A 1t88B-6fmlD:
undetectable		 1t88B-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gui -

(-) 		no annotation 4 PHE A 165
LEU A 153
VAL A  52
VAL A 126
 None
 1.20A 1t88B-6guiA:
undetectable		 1t88B-6guiA:
undetectable