SIMILAR PATTERNS OF AMINO ACIDS FOR 1T88_A_CAMA1422

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 PHE A 531
VAL A 504
GLY A 505
VAL A 513
 None
 0.95A 1t88A-1dedA:
undetectable		 1t88A-1dedA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuj PR3

(Homo sapiens) 		PF00089
(Trypsin) 		4 PHE A 228
GLY A 193
VAL A 216
ASP A 226
 None
 0.99A 1t88A-1fujA:
undetectable		 1t88A-1fujA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		4 LEU A 419
VAL A 392
GLY A 391
VAL A 307
 NAP  A1581 (-4.4A)
NAP  A1581 (-4.3A)
None
None
 0.96A 1t88A-1gq2A:
0.0		 1t88A-1gq2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 LEU P 276
VAL P 310
GLY P 311
ASP P 290
 None
 0.72A 1t88A-1h71P:
0.0		 1t88A-1h71P:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hu3 EIF4GII

(Homo sapiens) 		PF02854
(MIF4G) 		4 VAL A 791
GLY A 790
VAL A 821
ASP A 783
 None
 1.01A 1t88A-1hu3A:
0.0		 1t88A-1hu3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iiw SLR1257 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00497
(SBP_bac_3) 		4 PHE A 192
TYR A  91
GLY A  29
VAL A  10
 None
 0.89A 1t88A-1iiwA:
undetectable		 1t88A-1iiwA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 PHE B 390
VAL B 275
GLY B 276
ASP B 347
 None
 0.96A 1t88A-1n60B:
0.0		 1t88A-1n60B:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE

(Xenopus laevis) 		no annotation 4 PHE A 156
VAL A 224
GLY A 223
VAL A  90
 None
 0.81A 1t88A-1oe5A:
undetectable		 1t88A-1oe5A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryn PROTEIN CRS2

(Zea mays) 		PF01195
(Pept_tRNA_hydro) 		4 LEU A 124
VAL A 120
GLY A  72
VAL A  62
 LEU  A 124 ( 0.6A)
VAL  A 120 ( 0.6A)
GLY  A  72 ( 0.0A)
VAL  A  62 ( 0.5A)
 0.91A 1t88A-1rynA:
0.0		 1t88A-1rynA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5a HYPOTHETICAL PROTEIN
YESE

(Bacillus
subtilis) 		PF12680
(SnoaL_2) 		4 TYR A  64
LEU A  70
GLY A  95
VAL A 130
 ACT  A 801 (-4.8A)
None
None
None
 0.86A 1t88A-1s5aA:
undetectable		 1t88A-1s5aA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN

(Shigella
flexneri) 		PF02578
(Cu-oxidase_4) 		4 LEU A 130
VAL A 134
GLY A 133
VAL A 205
 None
 0.99A 1t88A-1u05A:
undetectable		 1t88A-1u05A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		4 LEU A 101
VAL A  37
GLY A  38
VAL A  85
 None
 0.96A 1t88A-1ufrA:
undetectable		 1t88A-1ufrA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrm HYPOTHETICAL PROTEIN
TM1553

(Thermotoga
maritima) 		PF02424
(ApbE) 		4 LEU A 335
VAL A 289
GLY A 288
ASP A 316
 None
 0.84A 1t88A-1vrmA:
undetectable		 1t88A-1vrmA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs5 MEMBRANE LIPOPROTEIN
TPN32

(Treponema
pallidum) 		PF03180
(Lipoprotein_9) 		4 LEU A  36
VAL A   9
GLY A  10
VAL A 206
 None
 0.91A 1t88A-1xs5A:
undetectable		 1t88A-1xs5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 PHE A 150
LEU A  72
VAL A  77
GLY A  78
 None
 0.78A 1t88A-1y8pA:
undetectable		 1t88A-1y8pA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		4 TYR A  93
LEU A 150
VAL A 138
VAL A  81
 SAZ  A 709 (-4.9A)
None
None
None
 0.91A 1t88A-1yyrA:
undetectable		 1t88A-1yyrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo1 TRANSLATION
INITIATION FACTOR 2

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 VAL I 422
GLY I 403
VAL I 433
ASP I 431
 None
 1.01A 1t88A-1zo1I:
undetectable		 1t88A-1zo1I:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aao CALCIUM-DEPENDENT
PROTEIN KINASE,
ISOFORM AK1

(Arabidopsis
thaliana) 		PF13499
(EF-hand_7) 		4 PHE A  85
LEU A  53
VAL A  56
GLY A  57
 None
 0.92A 1t88A-2aaoA:
undetectable		 1t88A-2aaoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjg GTP-BINDING PROTEIN
ENGA

(Bacillus
subtilis) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 PHE A 395
LEU A 352
GLY A 422
VAL A 362
 None
 0.89A 1t88A-2hjgA:
undetectable		 1t88A-2hjgA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 387
VAL A 355
GLY A 354
ASP A  31
 None
 0.81A 1t88A-2hneA:
undetectable		 1t88A-2hneA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 454
GLY A 391
VAL A 205
ASP A 218
 None
 0.96A 1t88A-2iwzA:
undetectable		 1t88A-2iwzA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 TYR A 289
LEU A 250
VAL A 247
GLY A 248
 None
 0.92A 1t88A-2j1nA:
undetectable		 1t88A-2j1nA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 LEU B 244
VAL B 247
GLY B 248
ASP B 231
 None
 0.95A 1t88A-2jgzB:
undetectable		 1t88A-2jgzB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Methanothermobacter
thermautotrophicus) 		PF01641
(SelR) 		4 PHE A  90
LEU A 123
VAL A 114
VAL A  94
 None
 0.92A 1t88A-2k8dA:
undetectable		 1t88A-2k8dA:
17.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		7 PHE A  87
TYR A  96
LEU A 244
VAL A 247
GLY A 248
VAL A 295
ASP A 297
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-3.9A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
 0.21A 1t88A-2m56A:
68.6		 1t88A-2m56A:
99.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 PHE A  87
TYR A  96
LEU A 244
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
None
 0.62A 1t88A-2m56A:
68.6		 1t88A-2m56A:
99.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ma1 DNA HELICASE RECQ

(Deinococcus
radiodurans) 		PF00570
(HRDC) 		4 PHE A 563
VAL A 600
GLY A 597
VAL A 585
 None
 0.94A 1t88A-2ma1A:
undetectable		 1t88A-2ma1A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Pseudomonas sp.
101) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 217
VAL A 194
GLY A 195
VAL A 154
 None
 0.94A 1t88A-2nadA:
undetectable		 1t88A-2nadA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		4 LEU A 221
VAL A 224
GLY A 225
VAL A  89
 None
 0.42A 1t88A-2pd3A:
undetectable		 1t88A-2pd3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		4 LEU A 273
VAL A 276
GLY A 277
VAL A 148
 None
 0.91A 1t88A-2pfzA:
undetectable		 1t88A-2pfzA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 PHE A 281
VAL A 342
GLY A 343
VAL A 299
 None
 0.94A 1t88A-2vdcA:
undetectable		 1t88A-2vdcA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 PHE A 421
VAL A 270
GLY A 269
VAL A 316
 None
 0.99A 1t88A-2w40A:
undetectable		 1t88A-2w40A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		4 PHE A2367
VAL A2349
GLY A2350
VAL A2323
 None
 1.01A 1t88A-2ypdA:
undetectable		 1t88A-2ypdA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5x CYCLIN-A2

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 LEU B 253
VAL B 256
GLY B 257
ASP B 240
 None
 0.70A 1t88A-3f5xB:
undetectable		 1t88A-3f5xB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grh ACYL-COA THIOESTER
HYDROLASE YBGC

(Escherichia
coli) 		PF01095
(Pectinesterase) 		4 PHE A 267
VAL A 228
GLY A 261
VAL A 329
 None
 0.99A 1t88A-3grhA:
undetectable		 1t88A-3grhA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ius UNCHARACTERIZED
CONSERVED PROTEIN

(Ruegeria
pomeroyi) 		no annotation 4 LEU A 143
VAL A  95
GLY A  96
VAL A  77
 None
 0.97A 1t88A-3iusA:
undetectable		 1t88A-3iusA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcq PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Anaplasma
phagocytophilum) 		PF00551
(Formyl_trans_N) 		4 TYR A 176
VAL A   9
GLY A   8
VAL A  32
 None
 0.94A 1t88A-3kcqA:
undetectable		 1t88A-3kcqA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkl PROBABLE CHAPERONE
PROTEIN HSP33

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A  38
LEU A 235
VAL A 133
GLY A 132
 None
 0.91A 1t88A-3kklA:
undetectable		 1t88A-3kklA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		4 PHE A  85
TYR A  98
VAL A 292
GLY A 293
 None
None
None
PLP  A1001 ( 4.3A)
 0.88A 1t88A-3n2oA:
undetectable		 1t88A-3n2oA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 LEU A 350
VAL A 299
GLY A 300
VAL A 274
 None
 0.85A 1t88A-3n9vA:
undetectable		 1t88A-3n9vA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		4 PHE A 107
TYR A 120
VAL A 309
GLY A 310
 None
 0.91A 1t88A-3nzqA:
undetectable		 1t88A-3nzqA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkm CAS6 PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		4 LEU A 221
VAL A 224
GLY A 225
ASP A 172
 None
 0.74A 1t88A-3pkmA:
undetectable		 1t88A-3pkmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr1 PROBABLE GTP-BINDING
PROTEIN ENGB

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		4 PHE A  99
LEU A 110
VAL A  29
GLY A  30
 None
 1.01A 1t88A-3pr1A:
undetectable		 1t88A-3pr1A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 PHE A1532
LEU A1511
VAL A1498
VAL A1489
 None
None
None
GOL  A   1 ( 4.7A)
 0.97A 1t88A-3pvlA:
undetectable		 1t88A-3pvlA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		4 PHE A 586
LEU A 590
VAL A 444
ASP A 441
 None
 0.88A 1t88A-3t6gA:
undetectable		 1t88A-3t6gA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsn 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF04166
(PdxA) 		4 LEU A 164
VAL A 171
GLY A 172
ASP A 302
 None
 0.78A 1t88A-3tsnA:
undetectable		 1t88A-3tsnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		4 LEU A 279
VAL A 313
GLY A 314
ASP A 293
 None
 0.76A 1t88A-3vi1A:
undetectable		 1t88A-3vi1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbi TRAO PROTEIN

(Escherichia
coli) 		PF03524
(CagX) 		4 PHE B 955
VAL B1006
GLY B1007
VAL B 944
 None
 0.85A 1t88A-3zbiB:
undetectable		 1t88A-3zbiB:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		4 PHE A 186
VAL A 248
GLY A 249
VAL A 229
 None
 0.90A 1t88A-4acaA:
undetectable		 1t88A-4acaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aef NEOPULLULANASE
(ALPHA-AMYLASE II)

(Pyrococcus
furiosus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16561
(AMPK1_CBM) 		4 LEU A 642
VAL A 633
GLY A 632
VAL A 620
 None
 0.98A 1t88A-4aefA:
undetectable		 1t88A-4aefA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ano ESSB

(Geobacillus
thermodenitrificans) 		PF10140
(YukC) 		4 LEU A 103
VAL A 127
GLY A 126
VAL A  62
 None
 0.76A 1t88A-4anoA:
undetectable		 1t88A-4anoA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asm BETA-AGARASE D

(Zobellia
galactanivorans) 		no annotation 4 TYR B 194
LEU B 271
VAL B 262
GLY B 261
 None
 0.92A 1t88A-4asmB:
undetectable		 1t88A-4asmB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 297
VAL A 197
GLY A 198
VAL A 112
 None
 1.00A 1t88A-4bgqA:
undetectable		 1t88A-4bgqA:
23.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 TYR A  98
LEU A 252
GLY A 256
VAL A 303
ASP A 305
 None
HEM  A1418 (-4.0A)
HEM  A1418 (-3.8A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
 0.53A 1t88A-4c9mA:
58.8		 1t88A-4c9mA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 TYR A  98
LEU A 252
GLY A 256
VAL A 404
 None
HEM  A1418 (-4.0A)
HEM  A1418 (-3.8A)
GOL  A1419 (-3.5A)
 0.87A 1t88A-4c9mA:
58.8		 1t88A-4c9mA:
44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 6

(Homo sapiens) 		PF01398
(JAB)
PF13012
(MitMem_reg) 		4 PHE F 183
GLY F 123
VAL F 138
ASP F 135
 None
 0.98A 1t88A-4d10F:
undetectable		 1t88A-4d10F:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 PHE A  87
LEU A 250
GLY A 254
VAL A 301
 None
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
PEG  A 502 ( 4.5A)
 0.71A 1t88A-4dxyA:
51.9		 1t88A-4dxyA:
46.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3q TRANSCRIPTIONAL
REGULATORY PROTEIN
CBU_1566

(Coxiella
burnetii) 		PF01709
(Transcrip_reg) 		4 TYR A 239
VAL A  95
GLY A  91
VAL A 233
 None
 0.89A 1t88A-4f3qA:
undetectable		 1t88A-4f3qA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4w DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		4 LEU A 164
VAL A 143
GLY A 144
VAL A 111
 None
 0.80A 1t88A-4f4wA:
undetectable		 1t88A-4f4wA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 PHE A 427
VAL A 412
GLY A 411
VAL A 440
 None
 0.97A 1t88A-4f9oA:
undetectable		 1t88A-4f9oA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw9 MECHANOSENSITIVE
CHANNEL MSCS

(Helicobacter
pylori) 		PF00924
(MS_channel) 		4 LEU A  89
VAL A  92
GLY A  93
VAL A  61
 None
 0.87A 1t88A-4hw9A:
undetectable		 1t88A-4hw9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		4 PHE A 396
VAL A 354
GLY A 353
VAL A 423
 PHE  A 396 ( 1.3A)
VAL  A 354 ( 0.6A)
GLY  A 353 ( 0.0A)
VAL  A 423 ( 0.5A)
 0.80A 1t88A-4kqnA:
undetectable		 1t88A-4kqnA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 PHE A 221
VAL A 286
GLY A 287
VAL A 267
 None
 0.94A 1t88A-4lbwA:
undetectable		 1t88A-4lbwA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc8 RESTRICTION
ENDONUCLEASE ASPBHI

(Azoarcus sp.
BH72) 		PF04471
(Mrr_cat) 		4 PHE A 125
LEU A  57
VAL A  40
GLY A  39
 None
None
None
PO4  A 403 ( 4.4A)
 0.95A 1t88A-4oc8A:
undetectable		 1t88A-4oc8A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		4 LEU B 400
VAL B 372
GLY B 373
ASP B 350
 None
 1.00A 1t88A-4peqB:
undetectable		 1t88A-4peqB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uom FAB FRAGMENT HEAVY
CHAIN
FAB FRAGMENT LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 PHE H 102
VAL L  59
GLY L  58
ASP H 104
 None
 1.00A 1t88A-4uomH:
undetectable		 1t88A-4uomH:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A  89
VAL A  53
GLY A  54
ASP A  74
 None
None
None
P6G  A 705 ( 3.5A)
 0.35A 1t88A-4uzsA:
undetectable		 1t88A-4uzsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN
SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 PHE D 111
GLY E 237
VAL D  50
ASP D  99
 None
 1.01A 1t88A-4v1dD:
undetectable		 1t88A-4v1dD:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		4 PHE A 163
TYR A 202
VAL A 151
VAL A 117
 None
 0.91A 1t88A-4y96A:
undetectable		 1t88A-4y96A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 LEU A 814
VAL A 790
GLY A 789
VAL A 781
 None
 0.98A 1t88A-4ypjA:
undetectable		 1t88A-4ypjA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 PHE A 870
TYR A 869
VAL A 792
GLY A 796
 None
 0.87A 1t88A-5aw4A:
undetectable		 1t88A-5aw4A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az0 UNCHARACTERIZED
PROTEIN

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		4 PHE A 317
VAL A  28
GLY A  27
VAL A 313
 None
 0.67A 1t88A-5az0A:
undetectable		 1t88A-5az0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp3 MYCOCEROSIC ACID
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF14765
(PS-DH) 		4 LEU A1172
VAL A1125
GLY A1124
ASP A1100
 None
 0.95A 1t88A-5bp3A:
undetectable		 1t88A-5bp3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		4 LEU A  26
GLY A  30
VAL A  41
ASP A  43
 None
None
None
SAH  A 301 ( 4.5A)
 0.96A 1t88A-5bp7A:
undetectable		 1t88A-5bp7A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		4 LEU A 210
GLY A 185
VAL A 164
ASP A 202
 None
 0.95A 1t88A-5bwiA:
undetectable		 1t88A-5bwiA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 PHE A 244
VAL A 280
GLY A 281
VAL A 110
 None
 0.90A 1t88A-5bwyA:
undetectable		 1t88A-5bwyA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME

(Aster yellows
witches'-broom
phytoplasma) 		PF00390
(malic)
PF03949
(Malic_M) 		4 LEU A 283
VAL A 260
GLY A 259
VAL A 187
 NAD  A 401 (-4.2A)
NAD  A 401 (-3.5A)
None
None
 1.00A 1t88A-5ceeA:
undetectable		 1t88A-5ceeA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN

(Chaetomium
thermophilum) 		PF09439
(SRPRB) 		4 LEU B  75
VAL B  83
GLY B  84
ASP B 133
 None
 0.71A 1t88A-5ck3B:
undetectable		 1t88A-5ck3B:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A  87
VAL A  51
GLY A  52
ASP A  72
 None
 0.49A 1t88A-5dfaA:
undetectable		 1t88A-5dfaA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A  85
VAL A  49
GLY A  50
ASP A  70
 None
 0.48A 1t88A-5e9aA:
undetectable		 1t88A-5e9aA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE

(Thiobacillus
denitrificans) 		PF13847
(Methyltransf_31) 		4 LEU A  25
GLY A  29
VAL A  40
ASP A  42
 None
None
None
SAH  A 301 ( 4.5A)
 0.97A 1t88A-5epeA:
undetectable		 1t88A-5epeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex8 CYTOCHROME P450

(Streptomyces
toyocaensis) 		PF00067
(p450) 		4 PHE A 104
LEU A  85
GLY A  83
VAL A 209
 None
HEM  A 401 (-3.9A)
None
None
 0.97A 1t88A-5ex8A:
33.7		 1t88A-5ex8A:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5v PRP38

(Chaetomium
thermophilum) 		PF03371
(PRP38) 		4 TYR A 105
LEU A 119
VAL A  65
VAL A  56
 None
 0.95A 1t88A-5f5vA:
undetectable		 1t88A-5f5vA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		4 PHE A2367
VAL A2349
GLY A2350
VAL A2323
 None
 1.01A 1t88A-5fzoA:
undetectable		 1t88A-5fzoA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 PHE A 825
VAL A 787
GLY A 786
ASP A 800
 None
 0.86A 1t88A-5hjrA:
undetectable		 1t88A-5hjrA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioo AVPA

(Nanoarchaeota
archaeon JGI
OTU-1) 		no annotation 4 LEU A  53
VAL A 186
GLY A 187
VAL A 162
 None
 0.85A 1t88A-5iooA:
undetectable		 1t88A-5iooA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A 324
LEU A 196
GLY A 223
VAL A 320
 None
 0.98A 1t88A-5jjqA:
undetectable		 1t88A-5jjqA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqp GLUCOSIDASE 2
SUBUNIT BETA-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF12999
(PRKCSH-like) 		4 PHE B  42
VAL B  28
GLY B  27
ASP B  69
 None
None
None
CA  B1001 (-3.3A)
 1.00A 1t88A-5jqpB:
undetectable		 1t88A-5jqpB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd0 AROMATIC
PRENYLTRANSFERASE

(Aspergillus
terreus) 		PF11991
(Trp_DMAT) 		4 LEU A 265
VAL A 255
GLY A 254
VAL A 152
 None
 0.66A 1t88A-5kd0A:
undetectable		 1t88A-5kd0A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 PHE A 832
LEU A 761
VAL A 764
GLY A 765
 None
 0.96A 1t88A-5m59A:
undetectable		 1t88A-5m59A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LEU A  57
VAL A  38
GLY A  39
ASP A 430
 None
 0.97A 1t88A-5neuA:
undetectable		 1t88A-5neuA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkp KELCH-LIKE PROTEIN 3

(Homo sapiens) 		PF01344
(Kelch_1) 		4 LEU A 443
VAL A 438
GLY A 437
VAL A 343
 None
 0.82A 1t88A-5nkpA:
undetectable		 1t88A-5nkpA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocp -

(-) 		no annotation 4 LEU A  33
VAL A   3
GLY A   4
VAL A  87
 None
 0.77A 1t88A-5ocpA:
undetectable		 1t88A-5ocpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opz CHIX

(Serratia
marcescens) 		no annotation 4 LEU A  26
VAL A  22
GLY A  72
ASP A  76
 None
None
None
ZN  A 201 (-2.2A)
 0.87A 1t88A-5opzA:
undetectable		 1t88A-5opzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy7 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		4 PHE B 176
LEU B 187
VAL B 183
VAL B 318
 None
 0.98A 1t88A-5sy7B:
undetectable		 1t88A-5sy7B:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t7d PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF13420
(Acetyltransf_4) 		4 LEU A 148
VAL A 161
GLY A 162
VAL A 123
 None
 0.96A 1t88A-5t7dA:
undetectable		 1t88A-5t7dA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn5 2,2',3-TRIHYDROXY-3'
-METHOXY-5,5'-DICARB
OXYBIPHENYL
META-CLEAVAGE
COMPOUND HYDROLASE

(Sphingobium sp.
SYK-6) 		PF04909
(Amidohydro_2) 		4 PHE A 194
TYR A 190
VAL A 286
GLY A 285
 None
 0.98A 1t88A-5vn5A:
undetectable		 1t88A-5vn5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		4 LEU A 341
VAL A 344
GLY A 345
ASP A 381
 None
 0.62A 1t88A-5wu3A:
undetectable		 1t88A-5wu3A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		4 LEU A 341
VAL A 344
GLY A 345
ASP A 381
 None
None
None
MG  A1001 (-3.9A)
 0.61A 1t88A-5wu6A:
undetectable		 1t88A-5wu6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6flx ABC TRANSPORTER
SYSTEM, ATP-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		no annotation 4 LEU A 224
VAL A  60
GLY A  61
VAL A 248
 None
 0.94A 1t88A-6flxA:
undetectable		 1t88A-6flxA:
undetectable