SIMILAR PATTERNS OF AMINO ACIDS FOR 1T86_A_CAMA1422_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)


(Thermoplasma
acidophilum)
PF00118
(Cpn60_TCP1)
4 THR A 358
VAL A 310
VAL A 231
VAL A 347
None
0.94A 1t86A-1a6dA:
0.0
1t86A-1a6dA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (BETA
SUBUNIT)


(Thermoplasma
acidophilum)
PF00118
(Cpn60_TCP1)
4 THR B  97
THR B 158
LEU B  41
VAL B 492
None
0.92A 1t86A-1a6dB:
0.0
1t86A-1a6dB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)


(Streptomyces
griseus)
no annotation 4 THR A 334
LEU A 318
VAL A  79
VAL A  16
None
0.91A 1t86A-1bwdA:
0.0
1t86A-1bwdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)


(Thermotoga
maritima)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
4 LEU A 124
VAL A 127
VAL A 251
VAL A 336
None
0.92A 1t86A-1c3cA:
0.0
1t86A-1c3cA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em2 MLN64 PROTEIN

(Homo sapiens)
PF01852
(START)
4 THR A 408
THR A 313
LEU A 406
VAL A 314
None
0.87A 1t86A-1em2A:
0.0
1t86A-1em2A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE


(Homo sapiens)
PF00884
(Sulfatase)
4 PHE A 297
THR A  69
THR A 299
VAL A 241
None
0.94A 1t86A-1fsuA:
undetectable
1t86A-1fsuA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE


(Paracoccus
denitrificans)
PF13473
(Cupredoxin_1)
4 PHE A 549
TYR A 533
VAL A 487
VAL A 489
None
0.92A 1t86A-1fwxA:
0.0
1t86A-1fwxA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA


(Saccharomyces
cerevisiae)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
5 THR A  82
THR A  24
LEU A 227
VAL A  10
VAL A  12
None
1.47A 1t86A-1g7cA:
0.0
1t86A-1g7cA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8p MAGNESIUM-CHELATASE
38 KDA SUBUNIT


(Rhodobacter
capsulatus)
PF01078
(Mg_chelatase)
4 LEU A  65
VAL A  62
VAL A 213
VAL A  50
None
0.81A 1t86A-1g8pA:
0.0
1t86A-1g8pA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8p MAGNESIUM-CHELATASE
38 KDA SUBUNIT


(Rhodobacter
capsulatus)
PF01078
(Mg_chelatase)
4 THR A  39
VAL A  62
VAL A 213
VAL A  50
None
0.75A 1t86A-1g8pA:
0.0
1t86A-1g8pA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6k 20 KDA NUCLEAR CAP
BINDING PROTEIN


(Homo sapiens)
PF00076
(RRM_1)
4 THR X  51
THR X 113
LEU X 106
VAL X  86
None
0.93A 1t86A-1h6kX:
undetectable
1t86A-1h6kX:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554)
PF12708
(Pectate_lyase_3)
4 THR A 438
THR A 450
VAL A 434
VAL A 380
CA  A   3 (-3.3A)
None
None
None
0.91A 1t86A-1ktwA:
undetectable
1t86A-1ktwA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfp HYPOTHETICAL PROTEIN
AQ_1575


(Aquifex
aeolicus)
PF01709
(Transcrip_reg)
4 PHE A 117
LEU A 222
VAL A 234
VAL A 130
None
0.88A 1t86A-1lfpA:
undetectable
1t86A-1lfpA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mov GFP-LIKE
NON-FLUORESCENT
CHROMOPROTEIN


(Montipora
efflorescens)
PF01353
(GFP)
4 TYR A 181
THR A 179
THR A  73
VAL A 195
None
CRQ  A  66 ( 4.7A)
None
None
0.93A 1t86A-1movA:
undetectable
1t86A-1movA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE


(Pseudomonas
putida)
PF07992
(Pyr_redox_2)
PF14759
(Reductase_C)
4 THR A 274
THR A 110
LEU A 260
VAL A  10
None
FAD  A 749 (-4.2A)
None
None
0.88A 1t86A-1q1rA:
undetectable
1t86A-1q1rA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN


(Pseudomonas
aeruginosa)
PF13433
(Peripla_BP_5)
4 THR A  51
LEU A  38
VAL A  35
VAL A  80
None
0.94A 1t86A-1qnlA:
undetectable
1t86A-1qnlA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli)
PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small)
4 PHE X 493
LEU X 456
VAL X 560
VAL X 600
None
0.82A 1t86A-1r6bX:
undetectable
1t86A-1r6bX:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE


(Acetobacter
pasteurianus)
PF02129
(Peptidase_S15)
PF08530
(PepX_C)
4 THR A 447
LEU A 457
VAL A 524
VAL A 664
None
0.72A 1t86A-1ryyA:
undetectable
1t86A-1ryyA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6t PUTATIVE PROTEIN

(Aquifex
aeolicus)
PF01751
(Toprim)
4 PHE 1  69
VAL 1  54
VAL 1  93
VAL 1  65
None
0.79A 1t86A-1t6t1:
undetectable
1t86A-1t6t1:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria))
PF01270
(Glyco_hydro_8)
5 THR A 421
THR A 390
LEU A 325
VAL A 328
VAL A  64
None
1.25A 1t86A-1v5cA:
undetectable
1t86A-1v5cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9j BOLA-LIKE PROTEIN
RIKEN CDNA
1110025L05


(Mus musculus)
PF01722
(BolA)
4 LEU A  87
VAL A  83
VAL A  48
VAL A  66
None
0.59A 1t86A-1v9jA:
undetectable
1t86A-1v9jA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF00579
(tRNA-synt_1b)
5 PHE A 236
THR A 263
LEU A 303
VAL A 307
VAL A 244
None
1.33A 1t86A-1vbmA:
undetectable
1t86A-1vbmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgq FORMYL-COENZYME A
TRANSFERASE


(Oxalobacter
formigenes)
PF02515
(CoA_transf_3)
4 THR A 152
LEU A 205
VAL A 208
VAL A 251
None
0.67A 1t86A-1vgqA:
undetectable
1t86A-1vgqA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE


(Thermotoga
maritima)
PF00162
(PGK)
4 THR A 313
LEU A 178
VAL A 181
VAL A 191
None
0.81A 1t86A-1vpeA:
undetectable
1t86A-1vpeA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w15 SYNAPTOTAGMIN IV

(Rattus
norvegicus)
PF00168
(C2)
4 THR A 349
THR A 343
VAL A 376
VAL A 327
None
0.93A 1t86A-1w15A:
undetectable
1t86A-1w15A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1


(Thermus
thermophilus)
PF02347
(GDC-P)
5 PHE A 415
LEU A 393
VAL A 389
VAL A 363
VAL A 366
None
1.33A 1t86A-1wytA:
undetectable
1t86A-1wytA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II


(Sporidiobolus
salmonicolor)
PF01370
(Epimerase)
4 THR A 131
LEU A  32
VAL A  28
VAL A 204
NMN  A1001 (-4.2A)
None
None
None
0.87A 1t86A-1y1pA:
undetectable
1t86A-1y1pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE


(Saccharomyces
cerevisiae)
PF00343
(Phosphorylase)
4 THR A 506
LEU A 521
VAL A 802
VAL A 537
None
0.77A 1t86A-1ygpA:
undetectable
1t86A-1ygpA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv9 HYDROLASE, HALOACID
DEHALOGENASE FAMILY


(Enterococcus
faecalis)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
4 THR A 174
LEU A 143
VAL A 167
VAL A 170
None
0.91A 1t86A-1yv9A:
undetectable
1t86A-1yv9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides)
PF06330
(TRI5)
4 TYR A  93
LEU A 150
VAL A 138
VAL A  81
SAZ  A 709 (-4.9A)
None
None
None
0.92A 1t86A-1yyrA:
undetectable
1t86A-1yyrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z54 PROBABLE
THIOESTERASE


(Thermus
thermophilus)
PF03061
(4HBT)
4 THR A 105
LEU A  59
VAL A  75
VAL A  93
None
0.91A 1t86A-1z54A:
undetectable
1t86A-1z54A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3


(Saccharomyces
cerevisiae)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 TYR A 362
THR A 392
VAL A 479
VAL A 499
None
0.85A 1t86A-1zpuA:
undetectable
1t86A-1zpuA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaf ARGININE DEIMINASE

(Pseudomonas
aeruginosa)
PF02274
(Amidinotransf)
5 PHE A  58
THR A 408
VAL A 362
VAL A  69
VAL A  20
None
1.49A 1t86A-2aafA:
undetectable
1t86A-2aafA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3r PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
3-KINASE C2
DOMAIN-CONTAINING
ALPHA POLYPEPTIDE


(Mus musculus)
PF00168
(C2)
4 THR A1441
THR A1435
VAL A1469
VAL A1419
None
0.84A 1t86A-2b3rA:
undetectable
1t86A-2b3rA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA


(Escherichia
coli)
PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N)
4 THR A1367
THR A1088
VAL A1348
VAL A1090
None
0.91A 1t86A-2bruA:
undetectable
1t86A-2bruA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cm6 RABPHILIN-3A

(Rattus
norvegicus)
PF00168
(C2)
4 THR A 602
THR A 596
VAL A 629
VAL A 580
None
0.80A 1t86A-2cm6A:
undetectable
1t86A-2cm6A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqz 177AA LONG
HYPOTHETICAL PROTEIN


(Pyrococcus
horikoshii)
PF13023
(HD_3)
4 LEU A  11
VAL A   8
VAL A  94
VAL A  98
None
0.91A 1t86A-2cqzA:
undetectable
1t86A-2cqzA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN


(Thermus
thermophilus)
PF00890
(FAD_binding_2)
PF07992
(Pyr_redox_2)
4 THR A 133
THR A 106
LEU A 118
VAL A   7
None
FAD  A2304 (-4.3A)
None
FAD  A2304 (-4.9A)
0.63A 1t86A-2cvjA:
undetectable
1t86A-2cvjA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE


(Acidithiobacillus
thiooxidans)
PF00180
(Iso_dh)
4 THR A 314
LEU A 326
VAL A 322
VAL A 293
None
0.86A 1t86A-2d4vA:
undetectable
1t86A-2d4vA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmg KIAA1228 PROTEIN

(Homo sapiens)
PF00168
(C2)
4 THR A  70
THR A  64
VAL A  97
VAL A  48
None
0.73A 1t86A-2dmgA:
undetectable
1t86A-2dmgA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2enp B/K PROTEIN

(Homo sapiens)
PF00168
(C2)
4 THR A  78
THR A  72
VAL A 105
VAL A  58
None
0.92A 1t86A-2enpA:
undetectable
1t86A-2enpA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7


(Arabidopsis
thaliana)
PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind)
4 LEU A 442
VAL A 408
VAL A 312
VAL A 280
None
0.91A 1t86A-2exrA:
undetectable
1t86A-2exrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm9 CELL INVASION
PROTEIN SIPA


(Salmonella
enterica)
PF09052
(SipA)
4 LEU A 222
VAL A 219
VAL A 183
VAL A 179
None
0.91A 1t86A-2fm9A:
undetectable
1t86A-2fm9A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2p TRANSTHYRETIN-LIKE
PROTEIN


(Escherichia
coli)
PF00576
(Transthyretin)
4 THR A  68
THR A 110
VAL A   8
VAL A  99
None
0.79A 1t86A-2g2pA:
undetectable
1t86A-2g2pA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpz TRANSTHYRETIN-LIKE
PROTEIN


(Salmonella
enterica)
PF00576
(Transthyretin)
4 THR A  69
THR A 111
VAL A   9
VAL A 100
None
0.84A 1t86A-2gpzA:
undetectable
1t86A-2gpzA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG


(Thermus
thermophilus)
PF05690
(ThiG)
5 THR A  41
THR A 148
LEU A 205
VAL A 182
VAL A   6
None
1.40A 1t86A-2htmA:
undetectable
1t86A-2htmA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus)
PF01707
(Peptidase_C9)
4 PHE A 761
THR A 704
LEU A 700
VAL A 745
None
0.89A 1t86A-2hwkA:
undetectable
1t86A-2hwkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0s AROMATIC AMINE
DEHYDROGENASE


(Alcaligenes
faecalis)
PF06433
(Me-amine-dh_H)
4 THR A 138
LEU A 163
VAL A 119
VAL A 127
None
0.86A 1t86A-2i0sA:
undetectable
1t86A-2i0sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES


(Bacillus cereus)
PF03486
(HI0933_like)
4 TYR A 138
LEU A 383
VAL A 159
VAL A 133
None
None
None
FAD  A 501 (-3.9A)
0.81A 1t86A-2i0zA:
undetectable
1t86A-2i0zA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE


(Bacillus
subtilis)
PF08543
(Phos_pyr_kin)
4 THR A 139
LEU A 226
VAL A 222
VAL A 176
None
0.91A 1t86A-2i5bA:
undetectable
1t86A-2i5bA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB


(Methanothermobacter
thermautotrophicus)
PF01641
(SelR)
4 LEU A 123
VAL A 114
VAL A  94
VAL A  93
None
0.90A 1t86A-2k8dA:
undetectable
1t86A-2k8dA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knb E3 UBIQUITIN-PROTEIN
LIGASE PARKIN


(Rattus
norvegicus)
PF00240
(ubiquitin)
4 THR A  21
VAL A  29
VAL A  67
VAL A   5
None
0.88A 1t86A-2knbA:
undetectable
1t86A-2knbA:
11.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
5 PHE A  87
TYR A  96
THR A 101
LEU A 244
VAL A 295
CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
HEM  A 501 (-4.6A)
0.99A 1t86A-2m56A:
68.1
1t86A-2m56A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
8 PHE A  87
TYR A  96
THR A 101
THR A 185
LEU A 244
VAL A 247
VAL A 295
VAL A 396
CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
None
HEM  A 501 (-4.5A)
None
HEM  A 501 (-4.6A)
None
0.34A 1t86A-2m56A:
68.1
1t86A-2m56A:
99.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE


(Homo sapiens)
PF00168
(C2)
4 THR A  60
THR A  54
VAL A  83
VAL A  43
None
0.84A 1t86A-2nq3A:
undetectable
1t86A-2nq3A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsq E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
PROTEIN


(Homo sapiens)
PF00168
(C2)
4 THR A  69
THR A  63
VAL A  93
VAL A  45
None
0.79A 1t86A-2nsqA:
undetectable
1t86A-2nsqA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyz HYPOTHETICAL PROTEIN
GAMMAHV.M3


(Murid
gammaherpesvirus
4)
PF09213
(M3)
4 THR A 183
LEU A  65
VAL A 153
VAL A 110
None
0.88A 1t86A-2nyzA:
undetectable
1t86A-2nyzA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae)
PF08596
(Lgl_C)
4 THR A 153
LEU A 192
VAL A 133
VAL A 143
None
0.88A 1t86A-2oajA:
undetectable
1t86A-2oajA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p67 LAO/AO TRANSPORT
SYSTEM KINASE


(Escherichia
coli)
PF03308
(ArgK)
4 THR A 154
VAL A 164
VAL A 122
VAL A  90
None
0.93A 1t86A-2p67A:
undetectable
1t86A-2p67A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT


(Exiguobacterium
sibiricum)
PF02655
(ATP-grasp_3)
4 THR A   9
THR A  90
VAL A 102
VAL A  98
None
0.91A 1t86A-2pn1A:
undetectable
1t86A-2pn1A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE


(Pseudomonas
putida)
PF00106
(adh_short)
4 LEU A 112
VAL A 115
VAL A 165
VAL A 166
None
0.79A 1t86A-2q2vA:
undetectable
1t86A-2q2vA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgx UBIQUITIN-CONJUGATIN
G ENZYME E2 Q1


(Homo sapiens)
PF00179
(UQ_con)
4 PHE A  74
VAL A 122
VAL A  29
VAL A  41
None
0.58A 1t86A-2qgxA:
undetectable
1t86A-2qgxA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU


(Mycobacterium
tuberculosis)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
4 THR A 111
LEU A  37
VAL A  40
VAL A   9
None
0.85A 1t86A-2qkxA:
undetectable
1t86A-2qkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME


(Aeropyrum
pernix)
PF00326
(Peptidase_S9)
4 TYR A 444
LEU A 568
VAL A 392
VAL A 363
None
0.90A 1t86A-2qzpA:
undetectable
1t86A-2qzpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd7 COMPLEMENT COMPONENT
C8 ALPHA CHAIN


(Homo sapiens)
PF01823
(MACPF)
4 THR A 410
THR A 260
LEU A 350
VAL A 386
None
0.85A 1t86A-2rd7A:
undetectable
1t86A-2rd7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE


(Mycolicibacterium
smegmatis)
PF02542
(YgbB)
4 LEU A 146
VAL A  42
VAL A 129
VAL A  99
None
None
EDO  A1160 (-4.9A)
None
0.93A 1t86A-2uzhA:
undetectable
1t86A-2uzhA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzp PROTEIN KINASE C
GAMMA TYPE


(Homo sapiens)
PF00168
(C2)
4 THR A 218
THR A 212
VAL A 244
VAL A 196
None
0.80A 1t86A-2uzpA:
undetectable
1t86A-2uzpA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6b L-LACTATE
DEHYDROGENASE


(Deinococcus
radiodurans)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 LEU A 269
VAL A 293
VAL A  93
VAL A 134
None
0.92A 1t86A-2v6bA:
undetectable
1t86A-2v6bA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x86 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E


(Escherichia
coli)
PF01370
(Epimerase)
4 THR A 250
LEU A 200
VAL A 295
VAL A 299
None
ADP  A 401 (-4.3A)
None
None
0.94A 1t86A-2x86A:
undetectable
1t86A-2x86A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5i S100 CALCIUM BINDING
PROTEIN Z


(Danio rerio)
PF01023
(S_100)
4 THR A  83
LEU A   5
VAL A  76
VAL A  79
None
0.85A 1t86A-2y5iA:
undetectable
1t86A-2y5iA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222


(Thermotoga
maritima)
PF00005
(ABC_tran)
4 LEU A  23
VAL A  26
VAL A  38
VAL A 209
None
0.89A 1t86A-2yz2A:
undetectable
1t86A-2yz2A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Bifidobacterium
longum)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
5 THR A1245
LEU A1140
VAL A1146
VAL A1163
VAL A1250
None
1.38A 1t86A-2zxqA:
undetectable
1t86A-2zxqA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP B


(Sulfurisphaera
tokodaii)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
4 LEU A 205
VAL A 208
VAL A 218
VAL A 232
None
0.81A 1t86A-3aizA:
undetectable
1t86A-3aizA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN


(Methylobacillus
flagellatus)
PF03069
(FmdA_AmdA)
4 TYR A 227
LEU A 279
VAL A 278
VAL A 223
None
0.90A 1t86A-3b9tA:
undetectable
1t86A-3b9tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cn7 CARBOXYLESTERASE

(Pseudomonas
aeruginosa)
PF02230
(Abhydrolase_2)
4 PHE A  45
THR A  43
LEU A 135
VAL A  39
None
0.82A 1t86A-3cn7A:
undetectable
1t86A-3cn7A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE


(Salmonella
enterica)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 PHE A  11
THR A 368
THR A  15
LEU A 398
VAL A 389
None
1.33A 1t86A-3dqqA:
undetectable
1t86A-3dqqA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwz BETA-LACTAMASE

(Mycobacterium
tuberculosis)
PF13354
(Beta-lactamase2)
4 PHE A  48
VAL A 305
VAL A 275
VAL A  63
None
0.73A 1t86A-3dwzA:
undetectable
1t86A-3dwzA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE


(Trichoderma
reesei)
PF00026
(Asp)
4 LEU A 123
VAL A 121
VAL A  96
VAL A  89
None
0.91A 1t86A-3emyA:
undetectable
1t86A-3emyA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epj TRNA
ISOPENTENYLTRANSFERA
SE


(Saccharomyces
cerevisiae)
PF01715
(IPPT)
5 TYR A 115
THR A 112
VAL A  50
VAL A 257
VAL A 254
A  E  36 ( 4.9A)
A  E  37 ( 2.5A)
None
A  E  37 ( 4.3A)
None
1.49A 1t86A-3epjA:
undetectable
1t86A-3epjA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f00 SYNAPTOTAGMIN-1

(Homo sapiens)
PF00168
(C2)
4 THR A 201
THR A 195
VAL A 228
VAL A 181
None
0.79A 1t86A-3f00A:
undetectable
1t86A-3f00A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN


(Geobacillus
kaustophilus)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
4 THR A1170
LEU A1206
VAL A1209
VAL A1190
None
0.67A 1t86A-3f2bA:
undetectable
1t86A-3f2bA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdw SYNAPTOTAGMIN-LIKE
PROTEIN 4


(Homo sapiens)
PF00168
(C2)
4 THR A 419
THR A 413
VAL A 446
VAL A 397
None
0.83A 1t86A-3fdwA:
undetectable
1t86A-3fdwA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn8 SYNAPTOTAGMIN-3

(Rattus
norvegicus)
PF00168
(C2)
4 THR A 357
THR A 351
VAL A 384
VAL A 337
None
0.81A 1t86A-3hn8A:
undetectable
1t86A-3hn8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn8 SYNAPTOTAGMIN-3

(Rattus
norvegicus)
PF00168
(C2)
4 THR A 491
THR A 485
VAL A 518
VAL A 469
None
0.89A 1t86A-3hn8A:
undetectable
1t86A-3hn8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE


(Nitrosospira
multiformis)
PF00365
(PFK)
4 LEU A 286
VAL A 282
VAL A 214
VAL A 243
None
0.72A 1t86A-3hnoA:
undetectable
1t86A-3hnoA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnr PROBABLE
METHYLTRANSFERASE
BT9727_4108


(Bacillus
thuringiensis)
PF08241
(Methyltransf_11)
4 LEU A  38
VAL A  41
VAL A  70
VAL A  49
None
0.84A 1t86A-3hnrA:
undetectable
1t86A-3hnrA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib6 UNCHARACTERIZED
PROTEIN


(Listeria
monocytogenes)
PF13419
(HAD_2)
4 THR A  12
LEU A 140
VAL A   5
VAL A 117
None
0.58A 1t86A-3ib6A:
undetectable
1t86A-3ib6A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1e CHAPERONIN BETA
SUBUNIT


(Acidianus
tengchongensis)
PF00118
(Cpn60_TCP1)
4 THR A 335
VAL A 297
VAL A 228
VAL A 368
None
0.86A 1t86A-3j1eA:
undetectable
1t86A-3j1eA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus)
no annotation 4 THR A 203
LEU A 349
VAL A 280
VAL A 134
None
0.91A 1t86A-3j3iA:
undetectable
1t86A-3j3iA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE


(Marinobacter
hydrocarbonoclasticus)
PF00365
(PFK)
4 LEU A 286
VAL A 282
VAL A 214
VAL A 243
None
0.88A 1t86A-3k2qA:
undetectable
1t86A-3k2qA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwu MUNC13-1

(Rattus
norvegicus)
PF00168
(C2)
4 THR A 781
LEU A 788
VAL A 716
VAL A 753
None
0.87A 1t86A-3kwuA:
undetectable
1t86A-3kwuA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN


(Parabacteroides
distasonis)
PF12979
(DUF3863)
PF12980
(DUF3864)
4 THR A 338
LEU A  53
VAL A  51
VAL A 290
None
0.89A 1t86A-3lm3A:
undetectable
1t86A-3lm3A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE


(Salmonella
enterica)
PF00756
(Esterase)
PF11806
(DUF3327)
4 THR A 191
THR A 390
LEU A 189
VAL A 216
None
0.93A 1t86A-3mgaA:
undetectable
1t86A-3mgaA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified)
PF01979
(Amidohydro_1)
4 THR A 351
THR A  54
LEU A  14
VAL A 389
None
0.75A 1t86A-3n2cA:
undetectable
1t86A-3n2cA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orf DIHYDROPTERIDINE
REDUCTASE


(Dictyostelium
discoideum)
PF00106
(adh_short)
4 LEU A 193
VAL A 196
VAL A   7
VAL A  72
None
0.82A 1t86A-3orfA:
undetectable
1t86A-3orfA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pop GILR OXIDASE

(Streptomyces
griseoflavus)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 THR A 489
LEU A  80
VAL A  58
VAL A 167
VAL A 161
None
1.50A 1t86A-3popA:
undetectable
1t86A-3popA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus)
PF00008
(EGF)
PF02210
(Laminin_G_2)
4 THR A 760
VAL A 803
VAL A 765
VAL A 837
None
0.94A 1t86A-3poyA:
undetectable
1t86A-3poyA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus)
PF00008
(EGF)
PF02210
(Laminin_G_2)
4 THR A 744
VAL A 787
VAL A 749
VAL A 821
None
0.88A 1t86A-3qcwA:
undetectable
1t86A-3qcwA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdm DMF4 BETA CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 THR E 108
THR E  13
LEU E  21
VAL E  19
None
0.92A 1t86A-3qdmE:
undetectable
1t86A-3qdmE:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsq CAPSID POLYPROTEIN

(Mamastrovirus 1)
PF12226
(Astro_capsid_p)
5 PHE A 638
THR A 591
LEU A 626
VAL A 484
VAL A 438
None
1.41A 1t86A-3qsqA:
undetectable
1t86A-3qsqA:
18.46