SIMILAR PATTERNS OF AMINO ACIDS FOR 1T86_A_CAMA1422_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a6d | THERMOSOME (ALPHASUBUNIT) (Thermoplasmaacidophilum) |
PF00118(Cpn60_TCP1) | 4 | THR A 358VAL A 310VAL A 231VAL A 347 | None | 0.94A | 1t86A-1a6dA:0.0 | 1t86A-1a6dA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a6d | THERMOSOME (BETASUBUNIT) (Thermoplasmaacidophilum) |
PF00118(Cpn60_TCP1) | 4 | THR B 97THR B 158LEU B 41VAL B 492 | None | 0.92A | 1t86A-1a6dB:0.0 | 1t86A-1a6dB:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bwd | PROTEIN(INOSAMINE-PHOSPHATEAMIDINOTRANSFERASE) (Streptomycesgriseus) |
no annotation | 4 | THR A 334LEU A 318VAL A 79VAL A 16 | None | 0.91A | 1t86A-1bwdA:0.0 | 1t86A-1bwdA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3c | PROTEIN(ADENYLOSUCCINATELYASE) (Thermotogamaritima) |
PF00206(Lyase_1)PF10397(ADSL_C) | 4 | LEU A 124VAL A 127VAL A 251VAL A 336 | None | 0.92A | 1t86A-1c3cA:0.0 | 1t86A-1c3cA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1em2 | MLN64 PROTEIN (Homo sapiens) |
PF01852(START) | 4 | THR A 408THR A 313LEU A 406VAL A 314 | None | 0.87A | 1t86A-1em2A:0.0 | 1t86A-1em2A:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fsu | N-ACETYLGALACTOSAMINE-4-SULFATASE (Homo sapiens) |
PF00884(Sulfatase) | 4 | PHE A 297THR A 69THR A 299VAL A 241 | None | 0.94A | 1t86A-1fsuA:undetectable | 1t86A-1fsuA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fwx | NITROUS OXIDEREDUCTASE (Paracoccusdenitrificans) |
PF13473(Cupredoxin_1) | 4 | PHE A 549TYR A 533VAL A 487VAL A 489 | None | 0.92A | 1t86A-1fwxA:0.0 | 1t86A-1fwxA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g7c | ELONGATION FACTOR1-ALPHA (Saccharomycescerevisiae) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 5 | THR A 82THR A 24LEU A 227VAL A 10VAL A 12 | None | 1.47A | 1t86A-1g7cA:0.0 | 1t86A-1g7cA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8p | MAGNESIUM-CHELATASE38 KDA SUBUNIT (Rhodobactercapsulatus) |
PF01078(Mg_chelatase) | 4 | LEU A 65VAL A 62VAL A 213VAL A 50 | None | 0.81A | 1t86A-1g8pA:0.0 | 1t86A-1g8pA:24.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8p | MAGNESIUM-CHELATASE38 KDA SUBUNIT (Rhodobactercapsulatus) |
PF01078(Mg_chelatase) | 4 | THR A 39VAL A 62VAL A 213VAL A 50 | None | 0.75A | 1t86A-1g8pA:0.0 | 1t86A-1g8pA:24.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h6k | 20 KDA NUCLEAR CAPBINDING PROTEIN (Homo sapiens) |
PF00076(RRM_1) | 4 | THR X 51THR X 113LEU X 106VAL X 86 | None | 0.93A | 1t86A-1h6kX:undetectable | 1t86A-1h6kX:13.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ktw | IOTA-CARRAGEENASE (Alteromonas sp.ATCC 43554) |
PF12708(Pectate_lyase_3) | 4 | THR A 438THR A 450VAL A 434VAL A 380 | CA A 3 (-3.3A)NoneNoneNone | 0.91A | 1t86A-1ktwA:undetectable | 1t86A-1ktwA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lfp | HYPOTHETICAL PROTEINAQ_1575 (Aquifexaeolicus) |
PF01709(Transcrip_reg) | 4 | PHE A 117LEU A 222VAL A 234VAL A 130 | None | 0.88A | 1t86A-1lfpA:undetectable | 1t86A-1lfpA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mov | GFP-LIKENON-FLUORESCENTCHROMOPROTEIN (Montiporaefflorescens) |
PF01353(GFP) | 4 | TYR A 181THR A 179THR A 73VAL A 195 | NoneCRQ A 66 ( 4.7A)NoneNone | 0.93A | 1t86A-1movA:undetectable | 1t86A-1movA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1r | PUTIDAREDOXINREDUCTASE (Pseudomonasputida) |
PF07992(Pyr_redox_2)PF14759(Reductase_C) | 4 | THR A 274THR A 110LEU A 260VAL A 10 | NoneFAD A 749 (-4.2A)NoneNone | 0.88A | 1t86A-1q1rA:undetectable | 1t86A-1q1rA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qnl | ALIPHATIC AMIDASEEXPRESSION-REGULATING PROTEIN (Pseudomonasaeruginosa) |
PF13433(Peripla_BP_5) | 4 | THR A 51LEU A 38VAL A 35VAL A 80 | None | 0.94A | 1t86A-1qnlA:undetectable | 1t86A-1qnlA:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r6b | CLPA PROTEIN (Escherichiacoli) |
PF00004(AAA)PF02861(Clp_N)PF07724(AAA_2)PF10431(ClpB_D2-small) | 4 | PHE X 493LEU X 456VAL X 560VAL X 600 | None | 0.82A | 1t86A-1r6bX:undetectable | 1t86A-1r6bX:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ryy | ALPHA-AMINO ACIDESTER HYDROLASE (Acetobacterpasteurianus) |
PF02129(Peptidase_S15)PF08530(PepX_C) | 4 | THR A 447LEU A 457VAL A 524VAL A 664 | None | 0.72A | 1t86A-1ryyA:undetectable | 1t86A-1ryyA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t6t | PUTATIVE PROTEIN (Aquifexaeolicus) |
PF01751(Toprim) | 4 | PHE 1 69VAL 1 54VAL 1 93VAL 1 65 | None | 0.79A | 1t86A-1t6t1:undetectable | 1t86A-1t6t1:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5c | CHITOSANASE (Bacillus sp.(in: Bacteria)) |
PF01270(Glyco_hydro_8) | 5 | THR A 421THR A 390LEU A 325VAL A 328VAL A 64 | None | 1.25A | 1t86A-1v5cA:undetectable | 1t86A-1v5cA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9j | BOLA-LIKE PROTEINRIKEN CDNA1110025L05 (Mus musculus) |
PF01722(BolA) | 4 | LEU A 87VAL A 83VAL A 48VAL A 66 | None | 0.59A | 1t86A-1v9jA:undetectable | 1t86A-1v9jA:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) |
PF00579(tRNA-synt_1b) | 5 | PHE A 236THR A 263LEU A 303VAL A 307VAL A 244 | None | 1.33A | 1t86A-1vbmA:undetectable | 1t86A-1vbmA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vgq | FORMYL-COENZYME ATRANSFERASE (Oxalobacterformigenes) |
PF02515(CoA_transf_3) | 4 | THR A 152LEU A 205VAL A 208VAL A 251 | None | 0.67A | 1t86A-1vgqA:undetectable | 1t86A-1vgqA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpe | PHOSPHOGLYCERATEKINASE (Thermotogamaritima) |
PF00162(PGK) | 4 | THR A 313LEU A 178VAL A 181VAL A 191 | None | 0.81A | 1t86A-1vpeA:undetectable | 1t86A-1vpeA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w15 | SYNAPTOTAGMIN IV (Rattusnorvegicus) |
PF00168(C2) | 4 | THR A 349THR A 343VAL A 376VAL A 327 | None | 0.93A | 1t86A-1w15A:undetectable | 1t86A-1w15A:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wyt | GLYCINEDEHYDROGENASE(DECARBOXYLATING)SUBUNIT 1 (Thermusthermophilus) |
PF02347(GDC-P) | 5 | PHE A 415LEU A 393VAL A 389VAL A 363VAL A 366 | None | 1.33A | 1t86A-1wytA:undetectable | 1t86A-1wytA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y1p | ALDEHYDE REDUCTASEII (Sporidiobolussalmonicolor) |
PF01370(Epimerase) | 4 | THR A 131LEU A 32VAL A 28VAL A 204 | NMN A1001 (-4.2A)NoneNoneNone | 0.87A | 1t86A-1y1pA:undetectable | 1t86A-1y1pA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ygp | YEAST GLYCOGENPHOSPHORYLASE (Saccharomycescerevisiae) |
PF00343(Phosphorylase) | 4 | THR A 506LEU A 521VAL A 802VAL A 537 | None | 0.77A | 1t86A-1ygpA:undetectable | 1t86A-1ygpA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yv9 | HYDROLASE, HALOACIDDEHALOGENASE FAMILY (Enterococcusfaecalis) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 4 | THR A 174LEU A 143VAL A 167VAL A 170 | None | 0.91A | 1t86A-1yv9A:undetectable | 1t86A-1yv9A:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yyr | TRICHODIENE SYNTHASE (Fusariumsporotrichioides) |
PF06330(TRI5) | 4 | TYR A 93LEU A 150VAL A 138VAL A 81 | SAZ A 709 (-4.9A)NoneNoneNone | 0.92A | 1t86A-1yyrA:undetectable | 1t86A-1yyrA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z54 | PROBABLETHIOESTERASE (Thermusthermophilus) |
PF03061(4HBT) | 4 | THR A 105LEU A 59VAL A 75VAL A 93 | None | 0.91A | 1t86A-1z54A:undetectable | 1t86A-1z54A:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zpu | IRON TRANSPORTMULTICOPPER OXIDASEFET3 (Saccharomycescerevisiae) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | TYR A 362THR A 392VAL A 479VAL A 499 | None | 0.85A | 1t86A-1zpuA:undetectable | 1t86A-1zpuA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aaf | ARGININE DEIMINASE (Pseudomonasaeruginosa) |
PF02274(Amidinotransf) | 5 | PHE A 58THR A 408VAL A 362VAL A 69VAL A 20 | None | 1.49A | 1t86A-2aafA:undetectable | 1t86A-2aafA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3r | PHOSPHATIDYLINOSITOL-4-PHOSPHATE3-KINASE C2DOMAIN-CONTAININGALPHA POLYPEPTIDE (Mus musculus) |
PF00168(C2) | 4 | THR A1441THR A1435VAL A1469VAL A1419 | None | 0.84A | 1t86A-2b3rA:undetectable | 1t86A-2b3rA:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bru | NAD(P)TRANSHYDROGENASESUBUNIT ALPHA (Escherichiacoli) |
PF01262(AlaDh_PNT_C)PF05222(AlaDh_PNT_N) | 4 | THR A1367THR A1088VAL A1348VAL A1090 | None | 0.91A | 1t86A-2bruA:undetectable | 1t86A-2bruA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cm6 | RABPHILIN-3A (Rattusnorvegicus) |
PF00168(C2) | 4 | THR A 602THR A 596VAL A 629VAL A 580 | None | 0.80A | 1t86A-2cm6A:undetectable | 1t86A-2cm6A:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cqz | 177AA LONGHYPOTHETICAL PROTEIN (Pyrococcushorikoshii) |
PF13023(HD_3) | 4 | LEU A 11VAL A 8VAL A 94VAL A 98 | None | 0.91A | 1t86A-2cqzA:undetectable | 1t86A-2cqzA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cvj | THIOREDOXINREDUCTASE RELATEDPROTEIN (Thermusthermophilus) |
PF00890(FAD_binding_2)PF07992(Pyr_redox_2) | 4 | THR A 133THR A 106LEU A 118VAL A 7 | NoneFAD A2304 (-4.3A)NoneFAD A2304 (-4.9A) | 0.63A | 1t86A-2cvjA:undetectable | 1t86A-2cvjA:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d4v | ISOCITRATEDEHYDROGENASE (Acidithiobacillusthiooxidans) |
PF00180(Iso_dh) | 4 | THR A 314LEU A 326VAL A 322VAL A 293 | None | 0.86A | 1t86A-2d4vA:undetectable | 1t86A-2d4vA:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dmg | KIAA1228 PROTEIN (Homo sapiens) |
PF00168(C2) | 4 | THR A 70THR A 64VAL A 97VAL A 48 | None | 0.73A | 1t86A-2dmgA:undetectable | 1t86A-2dmgA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2enp | B/K PROTEIN (Homo sapiens) |
PF00168(C2) | 4 | THR A 78THR A 72VAL A 105VAL A 58 | None | 0.92A | 1t86A-2enpA:undetectable | 1t86A-2enpA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2exr | CYTOKININDEHYDROGENASE 7 (Arabidopsisthaliana) |
PF01565(FAD_binding_4)PF09265(Cytokin-bind) | 4 | LEU A 442VAL A 408VAL A 312VAL A 280 | None | 0.91A | 1t86A-2exrA:undetectable | 1t86A-2exrA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fm9 | CELL INVASIONPROTEIN SIPA (Salmonellaenterica) |
PF09052(SipA) | 4 | LEU A 222VAL A 219VAL A 183VAL A 179 | None | 0.91A | 1t86A-2fm9A:undetectable | 1t86A-2fm9A:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g2p | TRANSTHYRETIN-LIKEPROTEIN (Escherichiacoli) |
PF00576(Transthyretin) | 4 | THR A 68THR A 110VAL A 8VAL A 99 | None | 0.79A | 1t86A-2g2pA:undetectable | 1t86A-2g2pA:12.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gpz | TRANSTHYRETIN-LIKEPROTEIN (Salmonellaenterica) |
PF00576(Transthyretin) | 4 | THR A 69THR A 111VAL A 9VAL A 100 | None | 0.84A | 1t86A-2gpzA:undetectable | 1t86A-2gpzA:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2htm | THIAZOLEBIOSYNTHESIS PROTEINTHIG (Thermusthermophilus) |
PF05690(ThiG) | 5 | THR A 41THR A 148LEU A 205VAL A 182VAL A 6 | None | 1.40A | 1t86A-2htmA:undetectable | 1t86A-2htmA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hwk | HELICASE NSP2 (Venezuelanequineencephalitisvirus) |
PF01707(Peptidase_C9) | 4 | PHE A 761THR A 704LEU A 700VAL A 745 | None | 0.89A | 1t86A-2hwkA:undetectable | 1t86A-2hwkA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i0s | AROMATIC AMINEDEHYDROGENASE (Alcaligenesfaecalis) |
PF06433(Me-amine-dh_H) | 4 | THR A 138LEU A 163VAL A 119VAL A 127 | None | 0.86A | 1t86A-2i0sA:undetectable | 1t86A-2i0sA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i0z | NAD(FAD)-UTILIZINGDEHYDROGENASES (Bacillus cereus) |
PF03486(HI0933_like) | 4 | TYR A 138LEU A 383VAL A 159VAL A 133 | NoneNoneNoneFAD A 501 (-3.9A) | 0.81A | 1t86A-2i0zA:undetectable | 1t86A-2i0zA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i5b | PHOSPHOMETHYLPYRIMIDINE KINASE (Bacillussubtilis) |
PF08543(Phos_pyr_kin) | 4 | THR A 139LEU A 226VAL A 222VAL A 176 | None | 0.91A | 1t86A-2i5bA:undetectable | 1t86A-2i5bA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k8d | PEPTIDE METHIONINESULFOXIDE REDUCTASEMSRB (Methanothermobacterthermautotrophicus) |
PF01641(SelR) | 4 | LEU A 123VAL A 114VAL A 94VAL A 93 | None | 0.90A | 1t86A-2k8dA:undetectable | 1t86A-2k8dA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2knb | E3 UBIQUITIN-PROTEINLIGASE PARKIN (Rattusnorvegicus) |
PF00240(ubiquitin) | 4 | THR A 21VAL A 29VAL A 67VAL A 5 | None | 0.88A | 1t86A-2knbA:undetectable | 1t86A-2knbA:11.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 5 | PHE A 87TYR A 96THR A 101LEU A 244VAL A 295 | CAM A 502 (-4.6A)CAM A 502 (-4.5A)HEM A 501 (-2.9A)HEM A 501 (-4.5A)HEM A 501 (-4.6A) | 0.99A | 1t86A-2m56A:68.1 | 1t86A-2m56A:99.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 8 | PHE A 87TYR A 96THR A 101THR A 185LEU A 244VAL A 247VAL A 295VAL A 396 | CAM A 502 (-4.6A)CAM A 502 (-4.5A)HEM A 501 (-2.9A)NoneHEM A 501 (-4.5A)NoneHEM A 501 (-4.6A)None | 0.34A | 1t86A-2m56A:68.1 | 1t86A-2m56A:99.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nq3 | ITCHY HOMOLOG E3UBIQUITIN PROTEINLIGASE (Homo sapiens) |
PF00168(C2) | 4 | THR A 60THR A 54VAL A 83VAL A 43 | None | 0.84A | 1t86A-2nq3A:undetectable | 1t86A-2nq3A:15.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nsq | E3 UBIQUITIN-PROTEINLIGASE NEDD4-LIKEPROTEIN (Homo sapiens) |
PF00168(C2) | 4 | THR A 69THR A 63VAL A 93VAL A 45 | None | 0.79A | 1t86A-2nsqA:undetectable | 1t86A-2nsqA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nyz | HYPOTHETICAL PROTEINGAMMAHV.M3 (Muridgammaherpesvirus4) |
PF09213(M3) | 4 | THR A 183LEU A 65VAL A 153VAL A 110 | None | 0.88A | 1t86A-2nyzA:undetectable | 1t86A-2nyzA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oaj | PROTEIN SNI1 (Saccharomycescerevisiae) |
PF08596(Lgl_C) | 4 | THR A 153LEU A 192VAL A 133VAL A 143 | None | 0.88A | 1t86A-2oajA:undetectable | 1t86A-2oajA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p67 | LAO/AO TRANSPORTSYSTEM KINASE (Escherichiacoli) |
PF03308(ArgK) | 4 | THR A 154VAL A 164VAL A 122VAL A 90 | None | 0.93A | 1t86A-2p67A:undetectable | 1t86A-2p67A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pn1 | CARBAMOYLPHOSPHATESYNTHASE LARGESUBUNIT (Exiguobacteriumsibiricum) |
PF02655(ATP-grasp_3) | 4 | THR A 9THR A 90VAL A 102VAL A 98 | None | 0.91A | 1t86A-2pn1A:undetectable | 1t86A-2pn1A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q2v | BETA-D-HYDROXYBUTYRATE DEHYDROGENASE (Pseudomonasputida) |
PF00106(adh_short) | 4 | LEU A 112VAL A 115VAL A 165VAL A 166 | None | 0.79A | 1t86A-2q2vA:undetectable | 1t86A-2q2vA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qgx | UBIQUITIN-CONJUGATING ENZYME E2 Q1 (Homo sapiens) |
PF00179(UQ_con) | 4 | PHE A 74VAL A 122VAL A 29VAL A 41 | None | 0.58A | 1t86A-2qgxA:undetectable | 1t86A-2qgxA:16.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qkx | BIFUNCTIONAL PROTEINGLMU (Mycobacteriumtuberculosis) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 4 | THR A 111LEU A 37VAL A 40VAL A 9 | None | 0.85A | 1t86A-2qkxA:undetectable | 1t86A-2qkxA:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzp | ACYLAMINO-ACID-RELEASING ENZYME (Aeropyrumpernix) |
PF00326(Peptidase_S9) | 4 | TYR A 444LEU A 568VAL A 392VAL A 363 | None | 0.90A | 1t86A-2qzpA:undetectable | 1t86A-2qzpA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rd7 | COMPLEMENT COMPONENTC8 ALPHA CHAIN (Homo sapiens) |
PF01823(MACPF) | 4 | THR A 410THR A 260LEU A 350VAL A 386 | None | 0.85A | 1t86A-2rd7A:undetectable | 1t86A-2rd7A:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uzh | 2C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Mycolicibacteriumsmegmatis) |
PF02542(YgbB) | 4 | LEU A 146VAL A 42VAL A 129VAL A 99 | NoneNoneEDO A1160 (-4.9A)None | 0.93A | 1t86A-2uzhA:undetectable | 1t86A-2uzhA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uzp | PROTEIN KINASE CGAMMA TYPE (Homo sapiens) |
PF00168(C2) | 4 | THR A 218THR A 212VAL A 244VAL A 196 | None | 0.80A | 1t86A-2uzpA:undetectable | 1t86A-2uzpA:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v6b | L-LACTATEDEHYDROGENASE (Deinococcusradiodurans) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | LEU A 269VAL A 293VAL A 93VAL A 134 | None | 0.92A | 1t86A-2v6bA:undetectable | 1t86A-2v6bA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x86 | ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE (Escherichiacoli) |
PF01370(Epimerase) | 4 | THR A 250LEU A 200VAL A 295VAL A 299 | NoneADP A 401 (-4.3A)NoneNone | 0.94A | 1t86A-2x86A:undetectable | 1t86A-2x86A:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y5i | S100 CALCIUM BINDINGPROTEIN Z (Danio rerio) |
PF01023(S_100) | 4 | THR A 83LEU A 5VAL A 76VAL A 79 | None | 0.85A | 1t86A-2y5iA:undetectable | 1t86A-2y5iA:13.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yz2 | PUTATIVE ABCTRANSPORTERATP-BINDING PROTEINTM_0222 (Thermotogamaritima) |
PF00005(ABC_tran) | 4 | LEU A 23VAL A 26VAL A 38VAL A 209 | None | 0.89A | 1t86A-2yz2A:undetectable | 1t86A-2yz2A:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zxq | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Bifidobacteriumlongum) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 5 | THR A1245LEU A1140VAL A1146VAL A1163VAL A1250 | None | 1.38A | 1t86A-2zxqA:undetectable | 1t86A-2zxqA:13.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aiz | DNA POLYMERASESLIDING CLAMP B (Sulfurisphaeratokodaii) |
PF00705(PCNA_N)PF02747(PCNA_C) | 4 | LEU A 205VAL A 208VAL A 218VAL A 232 | None | 0.81A | 1t86A-3aizA:undetectable | 1t86A-3aizA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9t | TWIN-ARGININETRANSLOCATIONPATHWAY SIGNALPROTEIN (Methylobacillusflagellatus) |
PF03069(FmdA_AmdA) | 4 | TYR A 227LEU A 279VAL A 278VAL A 223 | None | 0.90A | 1t86A-3b9tA:undetectable | 1t86A-3b9tA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cn7 | CARBOXYLESTERASE (Pseudomonasaeruginosa) |
PF02230(Abhydrolase_2) | 4 | PHE A 45THR A 43LEU A 135VAL A 39 | None | 0.82A | 1t86A-3cn7A:undetectable | 1t86A-3cn7A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dqq | PUTATIVE TRNASYNTHASE (Salmonellaenterica) |
PF07005(DUF1537)PF17042(DUF1357_C) | 5 | PHE A 11THR A 368THR A 15LEU A 398VAL A 389 | None | 1.33A | 1t86A-3dqqA:undetectable | 1t86A-3dqqA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwz | BETA-LACTAMASE (Mycobacteriumtuberculosis) |
PF13354(Beta-lactamase2) | 4 | PHE A 48VAL A 305VAL A 275VAL A 63 | None | 0.73A | 1t86A-3dwzA:undetectable | 1t86A-3dwzA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emy | TRICHODERMA REESEIASPARTIC PROTEASE (Trichodermareesei) |
PF00026(Asp) | 4 | LEU A 123VAL A 121VAL A 96VAL A 89 | None | 0.91A | 1t86A-3emyA:undetectable | 1t86A-3emyA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epj | TRNAISOPENTENYLTRANSFERASE (Saccharomycescerevisiae) |
PF01715(IPPT) | 5 | TYR A 115THR A 112VAL A 50VAL A 257VAL A 254 | A E 36 ( 4.9A) A E 37 ( 2.5A)None A E 37 ( 4.3A)None | 1.49A | 1t86A-3epjA:undetectable | 1t86A-3epjA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f00 | SYNAPTOTAGMIN-1 (Homo sapiens) |
PF00168(C2) | 4 | THR A 201THR A 195VAL A 228VAL A 181 | None | 0.79A | 1t86A-3f00A:undetectable | 1t86A-3f00A:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f2b | DNA-DIRECTED DNAPOLYMERASE III ALPHACHAIN (Geobacilluskaustophilus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 4 | THR A1170LEU A1206VAL A1209VAL A1190 | None | 0.67A | 1t86A-3f2bA:undetectable | 1t86A-3f2bA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fdw | SYNAPTOTAGMIN-LIKEPROTEIN 4 (Homo sapiens) |
PF00168(C2) | 4 | THR A 419THR A 413VAL A 446VAL A 397 | None | 0.83A | 1t86A-3fdwA:undetectable | 1t86A-3fdwA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn8 | SYNAPTOTAGMIN-3 (Rattusnorvegicus) |
PF00168(C2) | 4 | THR A 357THR A 351VAL A 384VAL A 337 | None | 0.81A | 1t86A-3hn8A:undetectable | 1t86A-3hn8A:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn8 | SYNAPTOTAGMIN-3 (Rattusnorvegicus) |
PF00168(C2) | 4 | THR A 491THR A 485VAL A 518VAL A 469 | None | 0.89A | 1t86A-3hn8A:undetectable | 1t86A-3hn8A:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hno | PYROPHOSPHATE-DEPENDENTPHOSPHOFRUCTOKINASE (Nitrosospiramultiformis) |
PF00365(PFK) | 4 | LEU A 286VAL A 282VAL A 214VAL A 243 | None | 0.72A | 1t86A-3hnoA:undetectable | 1t86A-3hnoA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hnr | PROBABLEMETHYLTRANSFERASEBT9727_4108 (Bacillusthuringiensis) |
PF08241(Methyltransf_11) | 4 | LEU A 38VAL A 41VAL A 70VAL A 49 | None | 0.84A | 1t86A-3hnrA:undetectable | 1t86A-3hnrA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib6 | UNCHARACTERIZEDPROTEIN (Listeriamonocytogenes) |
PF13419(HAD_2) | 4 | THR A 12LEU A 140VAL A 5VAL A 117 | None | 0.58A | 1t86A-3ib6A:undetectable | 1t86A-3ib6A:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j1e | CHAPERONIN BETASUBUNIT (Acidianustengchongensis) |
PF00118(Cpn60_TCP1) | 4 | THR A 335VAL A 297VAL A 228VAL A 368 | None | 0.86A | 1t86A-3j1eA:undetectable | 1t86A-3j1eA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j3i | CAPSID PROTEIN (Penicilliumchrysogenumvirus) |
no annotation | 4 | THR A 203LEU A 349VAL A 280VAL A 134 | None | 0.91A | 1t86A-3j3iA:undetectable | 1t86A-3j3iA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2q | PYROPHOSPHATE-DEPENDENTPHOSPHOFRUCTOKINASE (Marinobacterhydrocarbonoclasticus) |
PF00365(PFK) | 4 | LEU A 286VAL A 282VAL A 214VAL A 243 | None | 0.88A | 1t86A-3k2qA:undetectable | 1t86A-3k2qA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kwu | MUNC13-1 (Rattusnorvegicus) |
PF00168(C2) | 4 | THR A 781LEU A 788VAL A 716VAL A 753 | None | 0.87A | 1t86A-3kwuA:undetectable | 1t86A-3kwuA:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm3 | UNCHARACTERIZEDPROTEIN (Parabacteroidesdistasonis) |
PF12979(DUF3863)PF12980(DUF3864) | 4 | THR A 338LEU A 53VAL A 51VAL A 290 | None | 0.89A | 1t86A-3lm3A:undetectable | 1t86A-3lm3A:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mga | ENTEROCHELINESTERASE (Salmonellaenterica) |
PF00756(Esterase)PF11806(DUF3327) | 4 | THR A 191THR A 390LEU A 189VAL A 216 | None | 0.93A | 1t86A-3mgaA:undetectable | 1t86A-3mgaA:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2c | PROLIDASE (unidentified) |
PF01979(Amidohydro_1) | 4 | THR A 351THR A 54LEU A 14VAL A 389 | None | 0.75A | 1t86A-3n2cA:undetectable | 1t86A-3n2cA:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3orf | DIHYDROPTERIDINEREDUCTASE (Dictyosteliumdiscoideum) |
PF00106(adh_short) | 4 | LEU A 193VAL A 196VAL A 7VAL A 72 | None | 0.82A | 1t86A-3orfA:undetectable | 1t86A-3orfA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pop | GILR OXIDASE (Streptomycesgriseoflavus) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | THR A 489LEU A 80VAL A 58VAL A 167VAL A 161 | None | 1.50A | 1t86A-3popA:undetectable | 1t86A-3popA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3poy | NEUREXIN-1-ALPHA (Bos taurus) |
PF00008(EGF)PF02210(Laminin_G_2) | 4 | THR A 760VAL A 803VAL A 765VAL A 837 | None | 0.94A | 1t86A-3poyA:undetectable | 1t86A-3poyA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qcw | NEUREXIN-1-ALPHA (Bos taurus) |
PF00008(EGF)PF02210(Laminin_G_2) | 4 | THR A 744VAL A 787VAL A 749VAL A 821 | None | 0.88A | 1t86A-3qcwA:undetectable | 1t86A-3qcwA:15.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qdm | DMF4 BETA CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | THR E 108THR E 13LEU E 21VAL E 19 | None | 0.92A | 1t86A-3qdmE:undetectable | 1t86A-3qdmE:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qsq | CAPSID POLYPROTEIN (Mamastrovirus 1) |
PF12226(Astro_capsid_p) | 5 | PHE A 638THR A 591LEU A 626VAL A 484VAL A 438 | None | 1.41A | 1t86A-3qsqA:undetectable | 1t86A-3qsqA:18.46 |