SIMILAR PATTERNS OF AMINO ACIDS FOR 1T6Z_B_RBFB596_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoc COAGULOGEN

(Tachypleus
tridentatus)
PF02035
(Coagulin)
5 VAL A  98
VAL A 109
TYR A 152
GLU A  96
ILE A  30
None
1.19A 1t6zB-1aocA:
undetectable
1t6zB-1aocA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT


(Desulfovibrio
desulfuricans)
PF00374
(NiFeSe_Hases)
5 VAL B  31
GLU B 509
GLU B  30
LEU B  27
ILE B 530
None
1.11A 1t6zB-1e3dB:
undetectable
1t6zB-1e3dB:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF)
PF13091
(PLDc_2)
5 VAL A 454
VAL A 452
TYR A 460
LEU A  11
ILE A 477
None
0.92A 1t6zB-1f0iA:
undetectable
1t6zB-1f0iA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fob BETA-1,4-GALACTANASE

(Aspergillus
aculeatus)
PF07745
(Glyco_hydro_53)
5 VAL A 245
VAL A 243
TYR A 209
ARG A  45
GLU A 136
None
1.27A 1t6zB-1fobA:
undetectable
1t6zB-1fobA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcb GAL6 HG (EMTS)
DERIVATIVE


(Saccharomyces
cerevisiae)
PF03051
(Peptidase_C1_2)
5 GLU A 412
TYR A 410
ARG A  44
ILE A 340
ASP A 339
None
1.00A 1t6zB-1gcbA:
undetectable
1t6zB-1gcbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id2 AMICYANIN

(Paracoccus
versutus)
PF00127
(Copper-bind)
5 VAL A 105
VAL A 103
TYR A  91
GLU A  85
ILE A  81
None
1.38A 1t6zB-1id2A:
undetectable
1t6zB-1id2A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2


(Escherichia
coli)
PF02222
(ATP-grasp)
5 VAL A  70
VAL A  41
GLU A  72
LEU A  99
ILE A  79
None
1.35A 1t6zB-1kj9A:
2.2
1t6zB-1kj9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE


(Pseudomonas
fluorescens)
PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C)
5 VAL A 374
VAL A 318
ARG A 373
ILE A 232
ASP A 369
MTL  A5600 (-3.6A)
None
MTL  A5600 ( 3.1A)
MTL  A5600 (-4.5A)
None
1.19A 1t6zB-1m2wA:
1.2
1t6zB-1m2wA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n07 PUTATIVE RIBOFLAVIN
KINASE


(Schizosaccharomyces
pombe)
PF01687
(Flavokinase)
8 THR A  45
VAL A  64
VAL A  79
GLU A  96
ARG A 121
LEU A 132
ILE A 136
ASP A 139
FMN  A 165 (-4.4A)
FMN  A 165 (-4.3A)
FMN  A 165 ( 4.3A)
FMN  A 165 ( 2.8A)
FMN  A 165 (-2.9A)
FMN  A 165 (-4.5A)
FMN  A 165 ( 4.4A)
FMN  A 165 (-4.7A)
0.64A 1t6zB-1n07A:
9.0
1t6zB-1n07A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4m RIBOFLAVIN KINASE

(Homo sapiens)
PF01687
(Flavokinase)
7 THR A  34
VAL A  69
GLU A  86
ARG A 111
LEU A 122
ILE A 126
ASP A 129
MG  A 201 (-3.2A)
FMN  A 401 (-4.6A)
FMN  A 401 (-2.9A)
FMN  A 401 (-2.6A)
FMN  A 401 ( 4.7A)
FMN  A 401 ( 4.3A)
FMN  A 401 (-4.4A)
0.71A 1t6zB-1p4mA:
8.3
1t6zB-1p4mA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4m RIBOFLAVIN KINASE

(Homo sapiens)
PF01687
(Flavokinase)
7 VAL A  69
GLU A  86
ARG A 111
GLU A 113
LEU A 122
ILE A 126
ASP A 129
FMN  A 401 (-4.6A)
FMN  A 401 (-2.9A)
FMN  A 401 (-2.6A)
None
FMN  A 401 ( 4.7A)
FMN  A 401 ( 4.3A)
FMN  A 401 (-4.4A)
0.89A 1t6zB-1p4mA:
8.3
1t6zB-1p4mA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Escherichia
coli)
PF00275
(EPSP_synthase)
5 ASN A 217
GLU A 216
LEU A 177
ILE A 201
ASP A 202
None
1.40A 1t6zB-1p88A:
undetectable
1t6zB-1p88A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmo MANNOSE BINDING
LECTIN, FRIL


(Lablab
purpureus)
PF00139
(Lectin_legB)
5 VAL A  33
VAL E 236
ASN E 234
GLU E 232
LEU A 106
None
1.32A 1t6zB-1qmoA:
undetectable
1t6zB-1qmoA:
14.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE


(Thermotoga
maritima)
PF01687
(Flavokinase)
PF06574
(FAD_syn)
7 THR A 180
VAL A 197
ASN A 215
GLU A 231
ARG A 255
LEU A 266
ASP A 273
ADP  A 294 (-3.7A)
None
None
None
None
None
None
0.85A 1t6zB-1t6xA:
38.3
1t6zB-1t6xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE


(Thermotoga
maritima)
PF01687
(Flavokinase)
PF06574
(FAD_syn)
9 THR A 180
VAL A 197
VAL A 213
GLU A 231
ARG A 255
GLU A 257
LEU A 266
ILE A 270
ASP A 273
ADP  A 294 (-3.7A)
None
None
None
None
None
None
None
None
0.71A 1t6zB-1t6xA:
38.3
1t6zB-1t6xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE


(Thermotoga
maritima)
PF01687
(Flavokinase)
PF06574
(FAD_syn)
9 THR A 180
VAL A 197
VAL A 213
GLU A 231
TYR A 233
ARG A 255
GLU A 257
LEU A 266
ASP A 273
ADP  A 294 (-3.7A)
None
None
None
None
None
None
None
None
0.50A 1t6zB-1t6xA:
38.3
1t6zB-1t6xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Enterococcus
faecalis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 TYR A1360
GLU A1294
LEU A1033
ILE A1328
ASP A1327
None
1.32A 1t6zB-1wueA:
undetectable
1t6zB-1wueA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y81 CONSERVED
HYPOTHETICAL PROTEIN


(Pyrococcus
furiosus)
PF13380
(CoA_binding_2)
5 VAL A  82
VAL A 109
TYR A 111
GLU A  80
LEU A  75
None
1.36A 1t6zB-1y81A:
2.2
1t6zB-1y81A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj7 ESCJ

(Escherichia
coli)
PF01514
(YscJ_FliF)
5 VAL A  45
VAL A  61
ASN A  46
ARG A  68
ASP A  65
None
1.41A 1t6zB-1yj7A:
undetectable
1t6zB-1yj7A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE


(Pseudomonas
putida;
Spinacia
oleracea)
PF01070
(FMN_dh)
5 THR A 109
TYR A 131
GLU A 136
LEU A 203
ILE A 133
None
FMN  A 390 (-4.2A)
None
None
None
1.05A 1t6zB-2a7nA:
undetectable
1t6zB-2a7nA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN


(Pyrococcus
horikoshii)
PF03483
(B3_4)
PF03484
(B5)
5 VAL A 266
VAL A  93
TYR A 156
GLU A 274
LEU A 247
None
1.35A 1t6zB-2cxiA:
undetectable
1t6zB-2cxiA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A


(Escherichia
coli)
PF00171
(Aldedh)
5 VAL A 293
VAL A 260
TYR A 416
LEU A 389
ILE A 273
None
1.43A 1t6zB-2iluA:
2.7
1t6zB-2iluA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2


(Plasmodium
vivax)
PF00268
(Ribonuc_red_sm)
5 THR A 135
VAL A 128
ARG A 223
ILE A 221
ASP A 224
None
1.43A 1t6zB-2o1zA:
undetectable
1t6zB-2o1zA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owo DNA LIGASE

(Escherichia
coli)
PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5)
5 VAL A 121
VAL A 174
GLU A 169
LEU A 130
ILE A 155
None
1.37A 1t6zB-2owoA:
undetectable
1t6zB-2owoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN


(Homo sapiens)
PF00089
(Trypsin)
5 VAL S 154
ASN S  72
GLU S  77
GLU S  74
ASP S  21
None
None
CA  S1246 (-2.4A)
None
None
1.35A 1t6zB-2wpmS:
undetectable
1t6zB-2wpmS:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE


(Streptococcus
pneumoniae)
PF08305
(NPCBM)
5 VAL A 196
VAL A 174
GLU A 143
LEU A 227
ILE A 205
None
1.36A 1t6zB-2yglA:
undetectable
1t6zB-2yglA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum)
PF00759
(Glyco_hydro_9)
5 VAL A 184
VAL A 110
GLU A 127
ARG A 204
ASP A  76
None
None
None
ZN  A1533 ( 4.8A)
None
1.07A 1t6zB-2yikA:
undetectable
1t6zB-2yikA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus)
PF13091
(PLDc_2)
5 VAL A 448
VAL A 446
TYR A 454
LEU A   9
ILE A 471
None
0.95A 1t6zB-2ze4A:
2.7
1t6zB-2ze4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1)
no annotation 5 VAL A 261
GLU A 253
ARG A 171
GLU A 262
ASP A 268
None
1.36A 1t6zB-3ahmA:
undetectable
1t6zB-3ahmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asm RIBONUCLEASE HIII

(Geobacillus
stearothermophilus)
PF01351
(RNase_HII)
PF11858
(DUF3378)
5 VAL A 109
VAL A 248
TYR A 247
GLU A  98
ILE A 244
None
1.34A 1t6zB-3asmA:
undetectable
1t6zB-3asmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bnw RIBOFLAVIN KINASE,
PUTATIVE


(Trypanosoma
brucei)
PF01687
(Flavokinase)
5 VAL A  51
ARG A 117
LEU A 128
ILE A 132
ASP A 135
None
0.59A 1t6zB-3bnwA:
7.9
1t6zB-3bnwA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3k ALANINE RACEMASE

(Actinobacillus
succinogenes)
PF13377
(Peripla_BP_3)
5 VAL A 115
VAL A 217
GLU A 113
LEU A 150
ILE A 127
None
1.37A 1t6zB-3c3kA:
undetectable
1t6zB-3c3kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE


(Bacillus
halodurans)
PF13580
(SIS_2)
5 VAL A  34
VAL A 110
GLU A 205
LEU A 167
ILE A 138
None
1.39A 1t6zB-3cvjA:
undetectable
1t6zB-3cvjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN


(Pseudomonas
aeruginosa)
PF03349
(Toluene_X)
5 VAL X 173
VAL X 205
TYR X 244
ARG X 372
LEU X 419
C8E  X 454 ( 4.3A)
C8E  X 454 ( 4.1A)
None
C8E  X 454 ( 4.8A)
None
1.37A 1t6zB-3dwoX:
undetectable
1t6zB-3dwoX:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eiq PROGRAMMED CELL
DEATH PROTEIN 4


(Mus musculus)
PF02847
(MA3)
5 ASN C 276
TYR C 278
LEU C 302
ILE C 279
ASP C 280
None
1.37A 1t6zB-3eiqC:
undetectable
1t6zB-3eiqC:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emv URIDINE
PHOSPHORYLASE,
PUTATIVE


(Plasmodium
vivax)
PF01048
(PNP_UDP_1)
5 VAL A  20
VAL A  22
GLU A  52
LEU A  11
ILE A   9
None
1.44A 1t6zB-3emvA:
undetectable
1t6zB-3emvA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME


(Klebsiella
pneumoniae)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 VAL A  17
TYR A 370
LEU A 362
ILE A 338
ASP A 337
None
1.29A 1t6zB-3fcpA:
undetectable
1t6zB-3fcpA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus)
PF01728
(FtsJ)
5 THR A 118
ARG A  38
LEU A  45
ILE A  53
ASP A 257
None
SO4  A 268 (-3.9A)
None
None
None
1.09A 1t6zB-3gczA:
undetectable
1t6zB-3gczA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus)
PF01728
(FtsJ)
5 VAL A 230
VAL A 234
TYR A 188
LEU A 165
ILE A 192
None
1.45A 1t6zB-3gczA:
undetectable
1t6zB-3gczA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd9 LAMINARIPENTAOSE-PRO
DUCING
BETA-1,3-GULUASE
(LPHASE)


(Streptomyces
matensis)
PF16483
(Glyco_hydro_64)
5 VAL A 292
TYR A 273
ARG A 318
LEU A 325
ILE A 321
None
1.31A 1t6zB-3gd9A:
undetectable
1t6zB-3gd9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gff IROE-LIKE SERINE
HYDROLASE


(Shewanella
oneidensis)
PF00756
(Esterase)
5 ASN A 202
TYR A 241
LEU A 220
ILE A 200
ASP A 168
None
1.15A 1t6zB-3gffA:
undetectable
1t6zB-3gffA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gff IROE-LIKE SERINE
HYDROLASE


(Shewanella
oneidensis)
PF00756
(Esterase)
5 VAL A 249
TYR A 241
LEU A 220
ILE A 200
ASP A 168
None
1.23A 1t6zB-3gffA:
undetectable
1t6zB-3gffA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2


(Trypanosoma
brucei)
PF01704
(UDPGP)
5 VAL A 482
VAL A 480
ASN A 461
GLU A 465
ILE A 469
None
1.41A 1t6zB-3gueA:
undetectable
1t6zB-3gueA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5


(Saccharomyces
cerevisiae)
PF05916
(Sld5)
PF16922
(SLD5_C)
5 THR B  55
GLU D 132
ARG D 141
GLU D 134
ILE D  91
None
1.20A 1t6zB-3jc7B:
undetectable
1t6zB-3jc7B:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lib HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE


(Methanosarcina
mazei)
PF02743
(dCache_1)
5 THR A  74
VAL A 105
TYR A  78
LEU A  93
ILE A  89
None
1.35A 1t6zB-3libA:
undetectable
1t6zB-3libA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE


(Homo sapiens)
PF03372
(Exo_endo_phos)
5 VAL A 241
VAL A 196
TYR A 194
LEU A 254
ILE A 228
None
1.39A 1t6zB-3ngoA:
undetectable
1t6zB-3ngoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
5 VAL A 186
TYR A 243
GLU A 169
LEU A 206
ILE A 202
None
1.28A 1t6zB-3o5dA:
undetectable
1t6zB-3o5dA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
5 VAL A 212
VAL A 230
GLU A 210
LEU A 313
ILE A 242
None
1.12A 1t6zB-3ob8A:
undetectable
1t6zB-3ob8A:
14.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3op1 MACROLIDE-EFFLUX
PROTEIN


(Streptococcus
pneumoniae)
PF01687
(Flavokinase)
PF06574
(FAD_syn)
5 THR A 207
VAL A 223
ARG A 279
LEU A 290
ASP A 297
None
0.84A 1t6zB-3op1A:
25.9
1t6zB-3op1A:
30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3op1 MACROLIDE-EFFLUX
PROTEIN


(Streptococcus
pneumoniae)
PF01687
(Flavokinase)
PF06574
(FAD_syn)
5 THR A 246
VAL A 194
VAL A 211
ASN A 209
GLU A 255
None
1.31A 1t6zB-3op1A:
25.9
1t6zB-3op1A:
30.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq3 IFN-ALPHA/BETA
BINDING PROTEIN C12R


(Ectromelia
virus)
PF00047
(ig)
PF13895
(Ig_2)
5 VAL B 221
TYR B 135
LEU B 183
ILE B 185
ASP B 192
None
1.40A 1t6zB-3oq3B:
undetectable
1t6zB-3oq3B:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT


(uncultured
archaeon)
PF02240
(MCR_gamma)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
5 VAL C 224
ASN C 219
GLU A 405
TYR C 217
ASP C 229
None
1.27A 1t6zB-3sqgC:
undetectable
1t6zB-3sqgC:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT


(uncultured
archaeon)
PF02240
(MCR_gamma)
5 VAL C 224
ASN C 219
TYR C 217
LEU C 272
ASP C 229
None
1.23A 1t6zB-3sqgC:
undetectable
1t6zB-3sqgC:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuv ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE


(Plasmodium
falciparum)
PF05424
(Duffy_binding)
5 VAL A 317
ASN A 313
GLU A 231
GLU A 312
ILE A 271
None
1.27A 1t6zB-3vuvA:
undetectable
1t6zB-3vuvA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbb DIAMINOPIMELATE
DEHYDROGENASE


(Symbiobacterium
thermophilum)
PF01408
(GFO_IDH_MocA)
PF16654
(DAPDH_C)
5 VAL A 229
GLU A 232
LEU A 133
ILE A 129
ASP A 126
None
GOL  A 302 ( 4.7A)
None
None
None
1.11A 1t6zB-3wbbA:
3.2
1t6zB-3wbbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING


(Desulfovibrio
vulgaris)
PF00374
(NiFeSe_Hases)
5 VAL B  35
VAL B  37
GLU B 462
LEU B 482
ILE B 468
None
1.30A 1t6zB-3ze7B:
undetectable
1t6zB-3ze7B:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING


(Desulfovibrio
vulgaris)
PF00374
(NiFeSe_Hases)
5 VAL B 213
VAL B 217
GLU B 164
TYR B 221
ILE B 119
None
1.42A 1t6zB-3ze7B:
undetectable
1t6zB-3ze7B:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxy SUBTILISIN-LIKE
PROTEIN


(Prochloron
didemni)
PF00082
(Peptidase_S8)
5 VAL A 137
VAL A 168
GLU A 106
LEU A  22
ILE A 118
None
1.33A 1t6zB-3zxyA:
undetectable
1t6zB-3zxyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus)
PF01421
(Reprolysin)
5 VAL A  37
VAL A  51
GLU A  42
TYR A  44
GLU A  35
None
1.29A 1t6zB-4aigA:
undetectable
1t6zB-4aigA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b62 TSSL1

(Pseudomonas
aeruginosa)
PF00691
(OmpA)
5 VAL A 321
VAL A 323
GLU A 338
LEU A 355
ILE A 358
None
1.21A 1t6zB-4b62A:
undetectable
1t6zB-4b62A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE


(Lactococcus
lactis)
PF02811
(PHP)
5 TYR A   8
ARG A 234
GLU A  20
ILE A  37
ASP A   7
None
1.38A 1t6zB-4gk8A:
undetectable
1t6zB-4gk8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glx DNA LIGASE

(Escherichia
coli)
PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5)
5 VAL A 121
VAL A 174
GLU A 169
LEU A 130
ILE A 155
None
1.41A 1t6zB-4glxA:
undetectable
1t6zB-4glxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN


(Ustilago maydis)
PF01336
(tRNA_anti-codon)
PF08661
(Rep_fac-A_3)
5 VAL B  98
VAL B 107
GLU A   2
LEU B  57
ILE B  56
None
1.44A 1t6zB-4gnxB:
undetectable
1t6zB-4gnxB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hji CS1 FIMBRIAL SUBUNIT
A


(Escherichia
coli)
PF04449
(Fimbrial_CS1)
5 VAL A 153
VAL A  15
GLU A 154
LEU A  25
ASP A  16
None
1.40A 1t6zB-4hjiA:
undetectable
1t6zB-4hjiA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN


(Streptococcus
gordonii)
no annotation 5 THR D 418
VAL D 450
VAL D 321
ASN D 434
ILE D 432
None
1.42A 1t6zB-4igbD:
undetectable
1t6zB-4igbD:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana)
PF01432
(Peptidase_M3)
5 GLU A 436
TYR A 443
LEU A 450
ILE A 445
ASP A 444
None
1.38A 1t6zB-4ka8A:
undetectable
1t6zB-4ka8A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljs PERIPLASMIC BINDING
PROTEIN


(Veillonella
parvula)
PF01497
(Peripla_BP_2)
5 VAL A  63
VAL A 128
TYR A 153
GLU A  61
ILE A 180
None
0.94A 1t6zB-4ljsA:
2.5
1t6zB-4ljsA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7s BTRN

(Bacillus
circulans)
PF13186
(SPASM)
5 VAL A  12
GLU A  64
TYR A  90
LEU A 104
ILE A  89
None
1.30A 1t6zB-4m7sA:
undetectable
1t6zB-4m7sA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE


(Vibrio cholerae)
PF13302
(Acetyltransf_3)
5 VAL A  59
GLU A  72
LEU A  42
ILE A  18
ASP A  14
None
1.34A 1t6zB-4mi4A:
undetectable
1t6zB-4mi4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE


(Mycolicibacterium
smegmatis)
PF13439
(Glyco_transf_4)
PF13692
(Glyco_trans_1_4)
5 VAL A 363
ARG A 144
GLU A 139
LEU A 106
ILE A 113
None
1.31A 1t6zB-4n9wA:
undetectable
1t6zB-4n9wA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE


(Geobacillus
stearothermophilus)
PF16499
(Melibiase_2)
5 THR A 319
VAL A 371
VAL A 383
LEU A 430
ILE A 436
None
1.42A 1t6zB-4nxkA:
undetectable
1t6zB-4nxkA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmz XYLANASE

(Xanthomonas
citri)
PF00331
(Glyco_hydro_10)
5 VAL A 233
VAL A 275
GLU A 222
ARG A 271
LEU A 257
None
1.37A 1t6zB-4pmzA:
undetectable
1t6zB-4pmzA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica)
PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN)
5 VAL A 144
TYR A 138
GLU A 228
LEU A 226
ILE A 152
None
1.41A 1t6zB-4rf7A:
undetectable
1t6zB-4rf7A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqo L-SERINE DEHYDRATASE

(Legionella
pneumophila)
PF03313
(SDH_alpha)
PF03315
(SDH_beta)
5 VAL A 361
TYR A 317
LEU A 301
ILE A 316
ASP A 315
None
1.43A 1t6zB-4rqoA:
undetectable
1t6zB-4rqoA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trt DNA POLYMERASE III
SUBUNIT BETA


(Deinococcus
radiodurans)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
5 THR A  38
VAL A   6
VAL A  58
GLU A  88
LEU A  96
None
1.19A 1t6zB-4trtA:
undetectable
1t6zB-4trtA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus)
PF01966
(HD)
5 VAL A 274
VAL A 288
GLU A 276
LEU A 310
ILE A 236
None
1.40A 1t6zB-4uw2A:
undetectable
1t6zB-4uw2A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE


(Chlamydomonas
reinhardtii)
PF00194
(Carb_anhydrase)
5 VAL A 247
VAL A 266
GLU A 307
LEU A 301
ILE A  99
None
1.43A 1t6zB-4xixA:
undetectable
1t6zB-4xixA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica)
PF00961
(LAGLIDADG_1)
5 THR A  33
TYR A  31
GLU A 117
LEU A 127
ILE A  37
None
1.40A 1t6zB-4yisA:
undetectable
1t6zB-4yisA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjm LIPOPROTEIN LPQH

(Mycobacterium
tuberculosis)
PF05481
(Myco_19_kDa)
5 VAL C 135
VAL C  44
GLU C 132
LEU C  81
ILE C  64
None
1.37A 1t6zB-4zjmC:
undetectable
1t6zB-4zjmC:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF


(Corynebacterium
ammoniagenes)
PF01687
(Flavokinase)
6 THR A 208
VAL A 224
GLU A 268
ARG A 292
LEU A 303
ASP A 310
FMN  A 339 (-3.2A)
FMN  A 339 (-4.4A)
FMN  A 339 (-3.2A)
FMN  A 339 (-2.9A)
FMN  A 339 (-4.9A)
FMN  A 339 (-4.4A)
0.70A 1t6zB-5a89A:
9.1
1t6zB-5a89A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ag9 GINGIPAIN R2

(Porphyromonas
gingivalis)
PF03785
(Peptidase_C25_C)
5 VAL A 676
VAL A 733
TYR A 718
GLU A 686
ILE A 694
None
1.32A 1t6zB-5ag9A:
undetectable
1t6zB-5ag9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d88 PREDICTED PROTEASE
OF THE COLLAGENASE
FAMILY


(Methanopyrus
kandleri)
PF01136
(Peptidase_U32)
5 VAL A 179
ARG A 209
LEU A  36
ILE A 173
ASP A 177
None
None
ACT  A 302 (-3.9A)
ACT  A 302 (-3.8A)
None
1.28A 1t6zB-5d88A:
undetectable
1t6zB-5d88A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4s CONTACTIN-4

(Mus musculus)
PF00041
(fn3)
5 THR A 750
VAL A 777
GLU A 774
LEU A 716
ILE A 718
None
1.37A 1t6zB-5e4sA:
undetectable
1t6zB-5e4sA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ekz TRANSLATIONAL
ACTIVATOR OF
CYTOCHROME C OXIDASE
1


(Mus musculus)
PF01709
(Transcrip_reg)
5 VAL A 289
VAL A 286
TYR A 283
LEU A 165
ILE A 161
None
1.44A 1t6zB-5ekzA:
undetectable
1t6zB-5ekzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO


(Photobacterium
angustum)
PF00158
(Sigma54_activat)
5 VAL A 346
VAL A 378
GLU A 351
LEU A 362
ILE A 366
None
1.29A 1t6zB-5ep1A:
undetectable
1t6zB-5ep1A:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF


(Corynebacterium
ammoniagenes)
PF01687
(Flavokinase)
PF06574
(FAD_syn)
5 VAL A 224
GLU A 268
ARG A 292
LEU A 303
ASP A 310
None
0.65A 1t6zB-5fo1A:
27.2
1t6zB-5fo1A:
33.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00118
(Cpn60_TCP1)
5 THR a 333
VAL a 295
VAL a 242
LEU a 224
ILE a 374
None
1.08A 1t6zB-5gw5a:
undetectable
1t6zB-5gw5a:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA


(Homo sapiens)
no annotation 5 VAL B  28
TYR B  46
GLU B  30
LEU B  34
ILE B  92
None
1.35A 1t6zB-5iz5B:
undetectable
1t6zB-5iz5B:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jx3 URACIL-DNA
GLYCOSYLASE


(Vaccinia virus)
no annotation 5 VAL A 116
VAL A  64
TYR A 156
LEU A 202
ILE A 198
None
1.16A 1t6zB-5jx3A:
undetectable
1t6zB-5jx3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6m RIBONUCLEASE VAPC

(Caulobacter
vibrioides)
PF01850
(PIN)
5 VAL B   9
VAL B 110
TYR B   3
LEU B  66
ILE B  31
None
None
None
MLI  A 101 (-4.5A)
MLI  A 101 (-4.3A)
1.36A 1t6zB-5l6mB:
undetectable
1t6zB-5l6mB:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA


(Pyrococcus
furiosus)
PF08423
(Rad51)
5 THR A 310
VAL A 237
VAL A 279
GLU A 135
LEU A 261
None
0.89A 1t6zB-5l8vA:
undetectable
1t6zB-5l8vA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002


(Bacteroides
thetaiotaomicron)
no annotation 5 VAL A 509
VAL A 527
ASN A 512
GLU A 479
ILE A 468
None
1.31A 1t6zB-5mqpA:
undetectable
1t6zB-5mqpA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 VAL A 116
VAL A  96
TYR A  95
LEU A  60
ILE A  88
None
1.36A 1t6zB-5n9xA:
2.5
1t6zB-5n9xA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE


(Cupriavidus
necator)
PF07167
(PhaC_N)
5 THR A 472
VAL A 325
VAL A 315
LEU A 465
ILE A 468
None
1.43A 1t6zB-5t6oA:
undetectable
1t6zB-5t6oA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm2 ALCOHOL
DEHYDROGENASE


(Escherichia
coli)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 THR A 145
VAL A  71
VAL A  87
GLU A  34
ASP A  85
None
1.28A 1t6zB-5vm2A:
2.0
1t6zB-5vm2A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmk BIFUNCTIONAL PROTEIN
GLMU


(Acinetobacter
baumannii)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
PF14602
(Hexapep_2)
5 THR A 110
VAL A 103
GLU A 219
GLU A 221
ILE A 169
None
1.36A 1t6zB-5vmkA:
2.6
1t6zB-5vmkA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk7 MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12


(Saccharomyces
cerevisiae)
no annotation 5 THR B  60
GLU B  58
GLU B 124
LEU B 180
ILE B 167
None
1.24A 1t6zB-5yk7B:
undetectable
1t6zB-5yk7B:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywo 2F2 HEAVY CHAIN

(Mus musculus)
no annotation 5 VAL N 116
GLU N  10
LEU N  81
ILE N  83
ASP N  90
None
1.44A 1t6zB-5ywoN:
undetectable
1t6zB-5ywoN:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN


(Bordetella
bronchiseptica)
no annotation 5 THR A 397
VAL A 357
VAL A 401
LEU A 342
ILE A 346
None
1.06A 1t6zB-6au1A:
undetectable
1t6zB-6au1A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus)
no annotation 5 THR A 259
VAL A 505
VAL A 527
TYR A 258
GLU A 444
None
1.34A 1t6zB-6begA:
undetectable
1t6zB-6begA:
undetectable