SIMILAR PATTERNS OF AMINO ACIDS FOR 1T6Z_B_RBFB596
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aoc | COAGULOGEN (Tachypleustridentatus) |
PF02035(Coagulin) | 5 | VAL A 98VAL A 109TYR A 152GLU A 96ILE A 30 | None | 1.19A | 1t6zB-1aocA:undetectable | 1t6zB-1aocA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e3d | [NIFE] HYDROGENASELARGE SUBUNIT (Desulfovibriodesulfuricans) |
PF00374(NiFeSe_Hases) | 5 | VAL B 31GLU B 509GLU B 30LEU B 27ILE B 530 | None | 1.11A | 1t6zB-1e3dB:undetectable | 1t6zB-1e3dB:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f0i | PHOSPHOLIPASE D (Streptomycessp. PMF) |
PF13091(PLDc_2) | 5 | VAL A 454VAL A 452TYR A 460LEU A 11ILE A 477 | None | 0.92A | 1t6zB-1f0iA:undetectable | 1t6zB-1f0iA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fob | BETA-1,4-GALACTANASE (Aspergillusaculeatus) |
PF07745(Glyco_hydro_53) | 5 | VAL A 245VAL A 243TYR A 209ARG A 45GLU A 136 | None | 1.27A | 1t6zB-1fobA:undetectable | 1t6zB-1fobA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gcb | GAL6 HG (EMTS)DERIVATIVE (Saccharomycescerevisiae) |
PF03051(Peptidase_C1_2) | 5 | GLU A 412TYR A 410ARG A 44ILE A 340ASP A 339 | None | 1.00A | 1t6zB-1gcbA:undetectable | 1t6zB-1gcbA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1id2 | AMICYANIN (Paracoccusversutus) |
PF00127(Copper-bind) | 5 | VAL A 105VAL A 103TYR A 91GLU A 85ILE A 81 | None | 1.38A | 1t6zB-1id2A:undetectable | 1t6zB-1id2A:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kj9 | PHOSPHORIBOSYLGLYCINAMIDEFORMYLTRANSFERASE 2 (Escherichiacoli) |
PF02222(ATP-grasp) | 5 | VAL A 70VAL A 41GLU A 72LEU A 99ILE A 79 | None | 1.35A | 1t6zB-1kj9A:2.2 | 1t6zB-1kj9A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m2w | MANNITOLDEHYDROGENASE (Pseudomonasfluorescens) |
PF01232(Mannitol_dh)PF08125(Mannitol_dh_C) | 5 | VAL A 374VAL A 318ARG A 373ILE A 232ASP A 369 | MTL A5600 (-3.6A)NoneMTL A5600 ( 3.1A)MTL A5600 (-4.5A)None | 1.19A | 1t6zB-1m2wA:1.2 | 1t6zB-1m2wA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n07 | PUTATIVE RIBOFLAVINKINASE (Schizosaccharomycespombe) |
PF01687(Flavokinase) | 8 | THR A 45VAL A 64VAL A 79GLU A 96ARG A 121LEU A 132ILE A 136ASP A 139 | FMN A 165 (-4.4A)FMN A 165 (-4.3A)FMN A 165 ( 4.3A)FMN A 165 ( 2.8A)FMN A 165 (-2.9A)FMN A 165 (-4.5A)FMN A 165 ( 4.4A)FMN A 165 (-4.7A) | 0.64A | 1t6zB-1n07A:9.0 | 1t6zB-1n07A:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p4m | RIBOFLAVIN KINASE (Homo sapiens) |
PF01687(Flavokinase) | 7 | THR A 34VAL A 69GLU A 86ARG A 111LEU A 122ILE A 126ASP A 129 | MG A 201 (-3.2A)FMN A 401 (-4.6A)FMN A 401 (-2.9A)FMN A 401 (-2.6A)FMN A 401 ( 4.7A)FMN A 401 ( 4.3A)FMN A 401 (-4.4A) | 0.71A | 1t6zB-1p4mA:8.3 | 1t6zB-1p4mA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p4m | RIBOFLAVIN KINASE (Homo sapiens) |
PF01687(Flavokinase) | 7 | VAL A 69GLU A 86ARG A 111GLU A 113LEU A 122ILE A 126ASP A 129 | FMN A 401 (-4.6A)FMN A 401 (-2.9A)FMN A 401 (-2.6A)NoneFMN A 401 ( 4.7A)FMN A 401 ( 4.3A)FMN A 401 (-4.4A) | 0.89A | 1t6zB-1p4mA:8.3 | 1t6zB-1p4mA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p88 | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Escherichiacoli) |
PF00275(EPSP_synthase) | 5 | ASN A 217GLU A 216LEU A 177ILE A 201ASP A 202 | None | 1.40A | 1t6zB-1p88A:undetectable | 1t6zB-1p88A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qmo | MANNOSE BINDINGLECTIN, FRIL (Lablabpurpureus) |
PF00139(Lectin_legB) | 5 | VAL A 33VAL E 236ASN E 234GLU E 232LEU A 106 | None | 1.32A | 1t6zB-1qmoA:undetectable | 1t6zB-1qmoA:14.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t6x | RIBOFLAVINKINASE/FMNADENYLYLTRANSFERASE (Thermotogamaritima) |
PF01687(Flavokinase)PF06574(FAD_syn) | 7 | THR A 180VAL A 197ASN A 215GLU A 231ARG A 255LEU A 266ASP A 273 | ADP A 294 (-3.7A)NoneNoneNoneNoneNoneNone | 0.85A | 1t6zB-1t6xA:38.3 | 1t6zB-1t6xA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t6x | RIBOFLAVINKINASE/FMNADENYLYLTRANSFERASE (Thermotogamaritima) |
PF01687(Flavokinase)PF06574(FAD_syn) | 9 | THR A 180VAL A 197VAL A 213GLU A 231ARG A 255GLU A 257LEU A 266ILE A 270ASP A 273 | ADP A 294 (-3.7A)NoneNoneNoneNoneNoneNoneNoneNone | 0.71A | 1t6zB-1t6xA:38.3 | 1t6zB-1t6xA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t6x | RIBOFLAVINKINASE/FMNADENYLYLTRANSFERASE (Thermotogamaritima) |
PF01687(Flavokinase)PF06574(FAD_syn) | 9 | THR A 180VAL A 197VAL A 213GLU A 231TYR A 233ARG A 255GLU A 257LEU A 266ASP A 273 | ADP A 294 (-3.7A)NoneNoneNoneNoneNoneNoneNoneNone | 0.50A | 1t6zB-1t6xA:38.3 | 1t6zB-1t6xA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wue | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Enterococcusfaecalis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | TYR A1360GLU A1294LEU A1033ILE A1328ASP A1327 | None | 1.32A | 1t6zB-1wueA:undetectable | 1t6zB-1wueA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y81 | CONSERVEDHYPOTHETICAL PROTEIN (Pyrococcusfuriosus) |
PF13380(CoA_binding_2) | 5 | VAL A 82VAL A 109TYR A 111GLU A 80LEU A 75 | None | 1.36A | 1t6zB-1y81A:2.2 | 1t6zB-1y81A:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yj7 | ESCJ (Escherichiacoli) |
PF01514(YscJ_FliF) | 5 | VAL A 45VAL A 61ASN A 46ARG A 68ASP A 65 | None | 1.41A | 1t6zB-1yj7A:undetectable | 1t6zB-1yj7A:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a7n | L(+)-MANDELATEDEHYDROGENASE (Pseudomonasputida;Spinaciaoleracea) |
PF01070(FMN_dh) | 5 | THR A 109TYR A 131GLU A 136LEU A 203ILE A 133 | NoneFMN A 390 (-4.2A)NoneNoneNone | 1.05A | 1t6zB-2a7nA:undetectable | 1t6zB-2a7nA:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cxi | PHENYLALANYL-TRNASYNTHETASE BETACHAIN (Pyrococcushorikoshii) |
PF03483(B3_4)PF03484(B5) | 5 | VAL A 266VAL A 93TYR A 156GLU A 274LEU A 247 | None | 1.35A | 1t6zB-2cxiA:undetectable | 1t6zB-2cxiA:24.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ilu | ALDEHYDEDEHYDROGENASE A (Escherichiacoli) |
PF00171(Aldedh) | 5 | VAL A 293VAL A 260TYR A 416LEU A 389ILE A 273 | None | 1.43A | 1t6zB-2iluA:2.7 | 1t6zB-2iluA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o1z | RIBONUCLEOTIDEREDUCTASE SUBUNIT R2 (Plasmodiumvivax) |
PF00268(Ribonuc_red_sm) | 5 | THR A 135VAL A 128ARG A 223ILE A 221ASP A 224 | None | 1.43A | 1t6zB-2o1zA:undetectable | 1t6zB-2o1zA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2owo | DNA LIGASE (Escherichiacoli) |
PF01653(DNA_ligase_aden)PF03119(DNA_ligase_ZBD)PF03120(DNA_ligase_OB)PF12826(HHH_2)PF14520(HHH_5) | 5 | VAL A 121VAL A 174GLU A 169LEU A 130ILE A 155 | None | 1.37A | 1t6zB-2owoA:undetectable | 1t6zB-2owoA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wpm | COAGULATION FACTORIXA HEAVY CHAIN (Homo sapiens) |
PF00089(Trypsin) | 5 | VAL S 154ASN S 72GLU S 77GLU S 74ASP S 21 | NoneNone CA S1246 (-2.4A)NoneNone | 1.35A | 1t6zB-2wpmS:undetectable | 1t6zB-2wpmS:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ygl | BLOOD GROUP A-ANDB-CLEAVINGENDO-BETA-GALACTOSIDASE (Streptococcuspneumoniae) |
PF08305(NPCBM) | 5 | VAL A 196VAL A 174GLU A 143LEU A 227ILE A 205 | None | 1.36A | 1t6zB-2yglA:undetectable | 1t6zB-2yglA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yik | ENDOGLUCANASE (Ruminiclostridiumthermocellum) |
PF00759(Glyco_hydro_9) | 5 | VAL A 184VAL A 110GLU A 127ARG A 204ASP A 76 | NoneNoneNone ZN A1533 ( 4.8A)None | 1.07A | 1t6zB-2yikA:undetectable | 1t6zB-2yikA:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ze4 | PHOSPHOLIPASE D (Streptomycesantibioticus) |
PF13091(PLDc_2) | 5 | VAL A 448VAL A 446TYR A 454LEU A 9ILE A 471 | None | 0.95A | 1t6zB-2ze4A:2.7 | 1t6zB-2ze4A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahm | OLIGOPEPTIDASE (Geobacillus sp.MO-1) |
no annotation | 5 | VAL A 261GLU A 253ARG A 171GLU A 262ASP A 268 | None | 1.36A | 1t6zB-3ahmA:undetectable | 1t6zB-3ahmA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3asm | RIBONUCLEASE HIII (Geobacillusstearothermophilus) |
PF01351(RNase_HII)PF11858(DUF3378) | 5 | VAL A 109VAL A 248TYR A 247GLU A 98ILE A 244 | None | 1.34A | 1t6zB-3asmA:undetectable | 1t6zB-3asmA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bnw | RIBOFLAVIN KINASE,PUTATIVE (Trypanosomabrucei) |
PF01687(Flavokinase) | 5 | VAL A 51ARG A 117LEU A 128ILE A 132ASP A 135 | None | 0.59A | 1t6zB-3bnwA:7.9 | 1t6zB-3bnwA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3k | ALANINE RACEMASE (Actinobacillussuccinogenes) |
PF13377(Peripla_BP_3) | 5 | VAL A 115VAL A 217GLU A 113LEU A 150ILE A 127 | None | 1.37A | 1t6zB-3c3kA:undetectable | 1t6zB-3c3kA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cvj | PUTATIVEPHOSPHOHEPTOSEISOMERASE (Bacillushalodurans) |
PF13580(SIS_2) | 5 | VAL A 34VAL A 110GLU A 205LEU A 167ILE A 138 | None | 1.39A | 1t6zB-3cvjA:undetectable | 1t6zB-3cvjA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwo | PROBABLE OUTERMEMBRANE PROTEIN (Pseudomonasaeruginosa) |
PF03349(Toluene_X) | 5 | VAL X 173VAL X 205TYR X 244ARG X 372LEU X 419 | C8E X 454 ( 4.3A)C8E X 454 ( 4.1A)NoneC8E X 454 ( 4.8A)None | 1.37A | 1t6zB-3dwoX:undetectable | 1t6zB-3dwoX:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eiq | PROGRAMMED CELLDEATH PROTEIN 4 (Mus musculus) |
PF02847(MA3) | 5 | ASN C 276TYR C 278LEU C 302ILE C 279ASP C 280 | None | 1.37A | 1t6zB-3eiqC:undetectable | 1t6zB-3eiqC:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emv | URIDINEPHOSPHORYLASE,PUTATIVE (Plasmodiumvivax) |
PF01048(PNP_UDP_1) | 5 | VAL A 20VAL A 22GLU A 52LEU A 11ILE A 9 | None | 1.44A | 1t6zB-3emvA:undetectable | 1t6zB-3emvA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fcp | L-ALA-D/L-GLUEPIMERASE, AMUCONATE LACTONIZINGENZYME (Klebsiellapneumoniae) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | VAL A 17TYR A 370LEU A 362ILE A 338ASP A 337 | None | 1.29A | 1t6zB-3fcpA:undetectable | 1t6zB-3fcpA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gcz | POLYPROTEIN (Yokose virus) |
PF01728(FtsJ) | 5 | THR A 118ARG A 38LEU A 45ILE A 53ASP A 257 | NoneSO4 A 268 (-3.9A)NoneNoneNone | 1.09A | 1t6zB-3gczA:undetectable | 1t6zB-3gczA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gcz | POLYPROTEIN (Yokose virus) |
PF01728(FtsJ) | 5 | VAL A 230VAL A 234TYR A 188LEU A 165ILE A 192 | None | 1.45A | 1t6zB-3gczA:undetectable | 1t6zB-3gczA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gd9 | LAMINARIPENTAOSE-PRODUCINGBETA-1,3-GULUASE(LPHASE) (Streptomycesmatensis) |
PF16483(Glyco_hydro_64) | 5 | VAL A 292TYR A 273ARG A 318LEU A 325ILE A 321 | None | 1.31A | 1t6zB-3gd9A:undetectable | 1t6zB-3gd9A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gff | IROE-LIKE SERINEHYDROLASE (Shewanellaoneidensis) |
PF00756(Esterase) | 5 | ASN A 202TYR A 241LEU A 220ILE A 200ASP A 168 | None | 1.15A | 1t6zB-3gffA:undetectable | 1t6zB-3gffA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gff | IROE-LIKE SERINEHYDROLASE (Shewanellaoneidensis) |
PF00756(Esterase) | 5 | VAL A 249TYR A 241LEU A 220ILE A 200ASP A 168 | None | 1.23A | 1t6zB-3gffA:undetectable | 1t6zB-3gffA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gue | UTP-GLUCOSE-1-PHOSPHATEURIDYLYLTRANSFERASE2 (Trypanosomabrucei) |
PF01704(UDPGP) | 5 | VAL A 482VAL A 480ASN A 461GLU A 465ILE A 469 | None | 1.41A | 1t6zB-3gueA:undetectable | 1t6zB-3gueA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jc7 | DNA REPLICATIONCOMPLEX GINS PROTEINPSF2DNA REPLICATIONCOMPLEX GINS PROTEINSLD5 (Saccharomycescerevisiae) |
PF05916(Sld5)PF16922(SLD5_C) | 5 | THR B 55GLU D 132ARG D 141GLU D 134ILE D 91 | None | 1.20A | 1t6zB-3jc7B:undetectable | 1t6zB-3jc7B:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lib | HYPOTHETICAL SENSORYTRANSDUCTIONHISTIDINE KINASE (Methanosarcinamazei) |
PF02743(dCache_1) | 5 | THR A 74VAL A 105TYR A 78LEU A 93ILE A 89 | None | 1.35A | 1t6zB-3libA:undetectable | 1t6zB-3libA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ngo | CCR4-NOTTRANSCRIPTIONCOMPLEX SUBUNIT6-LIKE (Homo sapiens) |
PF03372(Exo_endo_phos) | 5 | VAL A 241VAL A 196TYR A 194LEU A 254ILE A 228 | None | 1.39A | 1t6zB-3ngoA:undetectable | 1t6zB-3ngoA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o5d | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP5 (Homo sapiens) |
PF00254(FKBP_C) | 5 | VAL A 186TYR A 243GLU A 169LEU A 206ILE A 202 | None | 1.28A | 1t6zB-3o5dA:undetectable | 1t6zB-3o5dA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ob8 | BETA-GALACTOSIDASE (Kluyveromyceslactis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N) | 5 | VAL A 212VAL A 230GLU A 210LEU A 313ILE A 242 | None | 1.12A | 1t6zB-3ob8A:undetectable | 1t6zB-3ob8A:14.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3op1 | MACROLIDE-EFFLUXPROTEIN (Streptococcuspneumoniae) |
PF01687(Flavokinase)PF06574(FAD_syn) | 5 | THR A 207VAL A 223ARG A 279LEU A 290ASP A 297 | None | 0.84A | 1t6zB-3op1A:25.9 | 1t6zB-3op1A:30.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3op1 | MACROLIDE-EFFLUXPROTEIN (Streptococcuspneumoniae) |
PF01687(Flavokinase)PF06574(FAD_syn) | 5 | THR A 246VAL A 194VAL A 211ASN A 209GLU A 255 | None | 1.31A | 1t6zB-3op1A:25.9 | 1t6zB-3op1A:30.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oq3 | IFN-ALPHA/BETABINDING PROTEIN C12R (Ectromeliavirus) |
PF00047(ig)PF13895(Ig_2) | 5 | VAL B 221TYR B 135LEU B 183ILE B 185ASP B 192 | None | 1.40A | 1t6zB-3oq3B:undetectable | 1t6zB-3oq3B:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqg | METHYL COENZYME MREDUCTASE, ALPHASUBUNITMETHYL-COENZYME MREDUCTASE, GAMMASUBUNIT (unculturedarchaeon) |
PF02240(MCR_gamma)PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | VAL C 224ASN C 219GLU A 405TYR C 217ASP C 229 | None | 1.27A | 1t6zB-3sqgC:undetectable | 1t6zB-3sqgC:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqg | METHYL-COENZYME MREDUCTASE, GAMMASUBUNIT (unculturedarchaeon) |
PF02240(MCR_gamma) | 5 | VAL C 224ASN C 219TYR C 217LEU C 272ASP C 229 | None | 1.23A | 1t6zB-3sqgC:undetectable | 1t6zB-3sqgC:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vuv | ERYTHROCYTE MEMBRANEPROTEIN, PUTATIVE (Plasmodiumfalciparum) |
PF05424(Duffy_binding) | 5 | VAL A 317ASN A 313GLU A 231GLU A 312ILE A 271 | None | 1.27A | 1t6zB-3vuvA:undetectable | 1t6zB-3vuvA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wbb | DIAMINOPIMELATEDEHYDROGENASE (Symbiobacteriumthermophilum) |
PF01408(GFO_IDH_MocA)PF16654(DAPDH_C) | 5 | VAL A 229GLU A 232LEU A 133ILE A 129ASP A 126 | NoneGOL A 302 ( 4.7A)NoneNoneNone | 1.11A | 1t6zB-3wbbA:3.2 | 1t6zB-3wbbA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ze7 | PERIPLASMIC [NIFESE]HYDROGENASE, LARGESUBUNIT,SELENOCYSTEINE-CONTAINING (Desulfovibriovulgaris) |
PF00374(NiFeSe_Hases) | 5 | VAL B 35VAL B 37GLU B 462LEU B 482ILE B 468 | None | 1.30A | 1t6zB-3ze7B:undetectable | 1t6zB-3ze7B:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ze7 | PERIPLASMIC [NIFESE]HYDROGENASE, LARGESUBUNIT,SELENOCYSTEINE-CONTAINING (Desulfovibriovulgaris) |
PF00374(NiFeSe_Hases) | 5 | VAL B 213VAL B 217GLU B 164TYR B 221ILE B 119 | None | 1.42A | 1t6zB-3ze7B:undetectable | 1t6zB-3ze7B:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zxy | SUBTILISIN-LIKEPROTEIN (Prochlorondidemni) |
PF00082(Peptidase_S8) | 5 | VAL A 137VAL A 168GLU A 106LEU A 22ILE A 118 | None | 1.33A | 1t6zB-3zxyA:undetectable | 1t6zB-3zxyA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aig | ADAMALYSIN II (Crotalusadamanteus) |
PF01421(Reprolysin) | 5 | VAL A 37VAL A 51GLU A 42TYR A 44GLU A 35 | None | 1.29A | 1t6zB-4aigA:undetectable | 1t6zB-4aigA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b62 | TSSL1 (Pseudomonasaeruginosa) |
PF00691(OmpA) | 5 | VAL A 321VAL A 323GLU A 338LEU A 355ILE A 358 | None | 1.21A | 1t6zB-4b62A:undetectable | 1t6zB-4b62A:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gk8 | HISTIDINOL-PHOSPHATASE (Lactococcuslactis) |
PF02811(PHP) | 5 | TYR A 8ARG A 234GLU A 20ILE A 37ASP A 7 | None | 1.38A | 1t6zB-4gk8A:undetectable | 1t6zB-4gk8A:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4glx | DNA LIGASE (Escherichiacoli) |
PF01653(DNA_ligase_aden)PF03119(DNA_ligase_ZBD)PF03120(DNA_ligase_OB)PF12826(HHH_2)PF14520(HHH_5) | 5 | VAL A 121VAL A 174GLU A 169LEU A 130ILE A 155 | None | 1.41A | 1t6zB-4glxA:undetectable | 1t6zB-4glxA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gnx | PUTATIVEUNCHARACTERIZEDPROTEIN (Ustilago maydis) |
PF01336(tRNA_anti-codon)PF08661(Rep_fac-A_3) | 5 | VAL B 98VAL B 107GLU A 2LEU B 57ILE B 56 | None | 1.44A | 1t6zB-4gnxB:undetectable | 1t6zB-4gnxB:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hji | CS1 FIMBRIAL SUBUNITA (Escherichiacoli) |
PF04449(Fimbrial_CS1) | 5 | VAL A 153VAL A 15GLU A 154LEU A 25ASP A 16 | None | 1.40A | 1t6zB-4hjiA:undetectable | 1t6zB-4hjiA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igb | LPXTG CELL WALLSURFACE PROTEIN (Streptococcusgordonii) |
no annotation | 5 | THR D 418VAL D 450VAL D 321ASN D 434ILE D 432 | None | 1.42A | 1t6zB-4igbD:undetectable | 1t6zB-4igbD:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ka8 | OLIGOPEPTIDASE A (Arabidopsisthaliana) |
PF01432(Peptidase_M3) | 5 | GLU A 436TYR A 443LEU A 450ILE A 445ASP A 444 | None | 1.38A | 1t6zB-4ka8A:undetectable | 1t6zB-4ka8A:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ljs | PERIPLASMIC BINDINGPROTEIN (Veillonellaparvula) |
PF01497(Peripla_BP_2) | 5 | VAL A 63VAL A 128TYR A 153GLU A 61ILE A 180 | None | 0.94A | 1t6zB-4ljsA:2.5 | 1t6zB-4ljsA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m7s | BTRN (Bacilluscirculans) |
PF13186(SPASM) | 5 | VAL A 12GLU A 64TYR A 90LEU A 104ILE A 89 | None | 1.30A | 1t6zB-4m7sA:undetectable | 1t6zB-4m7sA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mi4 | SPERMIDINEN1-ACETYLTRANSFERASE (Vibrio cholerae) |
PF13302(Acetyltransf_3) | 5 | VAL A 59GLU A 72LEU A 42ILE A 18ASP A 14 | None | 1.34A | 1t6zB-4mi4A:undetectable | 1t6zB-4mi4A:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n9w | GDP-MANNOSE-DEPENDENTALPHA-(1-2)-PHOSPHATIDYLINOSITOLMANNOSYLTRANSFERASE (Mycolicibacteriumsmegmatis) |
PF13439(Glyco_transf_4)PF13692(Glyco_trans_1_4) | 5 | VAL A 363ARG A 144GLU A 139LEU A 106ILE A 113 | None | 1.31A | 1t6zB-4n9wA:undetectable | 1t6zB-4n9wA:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nxk | ABP, A GH27BETA-L-ARABINOPYRANOSIDASE (Geobacillusstearothermophilus) |
PF16499(Melibiase_2) | 5 | THR A 319VAL A 371VAL A 383LEU A 430ILE A 436 | None | 1.42A | 1t6zB-4nxkA:undetectable | 1t6zB-4nxkA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pmz | XYLANASE (Xanthomonascitri) |
PF00331(Glyco_hydro_10) | 5 | VAL A 233VAL A 275GLU A 222ARG A 271LEU A 257 | None | 1.37A | 1t6zB-4pmzA:undetectable | 1t6zB-4pmzA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rf7 | ARGININE KINASE (Anthopleurajaponica) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 5 | VAL A 144TYR A 138GLU A 228LEU A 226ILE A 152 | None | 1.41A | 1t6zB-4rf7A:undetectable | 1t6zB-4rf7A:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rqo | L-SERINE DEHYDRATASE (Legionellapneumophila) |
PF03313(SDH_alpha)PF03315(SDH_beta) | 5 | VAL A 361TYR A 317LEU A 301ILE A 316ASP A 315 | None | 1.43A | 1t6zB-4rqoA:undetectable | 1t6zB-4rqoA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4trt | DNA POLYMERASE IIISUBUNIT BETA (Deinococcusradiodurans) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 5 | THR A 38VAL A 6VAL A 58GLU A 88LEU A 96 | None | 1.19A | 1t6zB-4trtA:undetectable | 1t6zB-4trtA:26.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uw2 | CSM1 (Thermococcusonnurineus) |
PF01966(HD) | 5 | VAL A 274VAL A 288GLU A 276LEU A 310ILE A 236 | None | 1.40A | 1t6zB-4uw2A:undetectable | 1t6zB-4uw2A:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xix | CARBONIC ANHYDRASE,ALPHA TYPE (Chlamydomonasreinhardtii) |
PF00194(Carb_anhydrase) | 5 | VAL A 247VAL A 266GLU A 307LEU A 301ILE A 99 | None | 1.43A | 1t6zB-4xixA:undetectable | 1t6zB-4xixA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yis | MEGANUCLEASE I-CPAMI (Cryphonectriaparasitica) |
PF00961(LAGLIDADG_1) | 5 | THR A 33TYR A 31GLU A 117LEU A 127ILE A 37 | None | 1.40A | 1t6zB-4yisA:undetectable | 1t6zB-4yisA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zjm | LIPOPROTEIN LPQH (Mycobacteriumtuberculosis) |
PF05481(Myco_19_kDa) | 5 | VAL C 135VAL C 44GLU C 132LEU C 81ILE C 64 | None | 1.37A | 1t6zB-4zjmC:undetectable | 1t6zB-4zjmC:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a89 | RIBOFLAVINBIOSYNTHESIS PROTEINRIBF (Corynebacteriumammoniagenes) |
PF01687(Flavokinase) | 6 | THR A 208VAL A 224GLU A 268ARG A 292LEU A 303ASP A 310 | FMN A 339 (-3.2A)FMN A 339 (-4.4A)FMN A 339 (-3.2A)FMN A 339 (-2.9A)FMN A 339 (-4.9A)FMN A 339 (-4.4A) | 0.70A | 1t6zB-5a89A:9.1 | 1t6zB-5a89A:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ag9 | GINGIPAIN R2 (Porphyromonasgingivalis) |
PF03785(Peptidase_C25_C) | 5 | VAL A 676VAL A 733TYR A 718GLU A 686ILE A 694 | None | 1.32A | 1t6zB-5ag9A:undetectable | 1t6zB-5ag9A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d88 | PREDICTED PROTEASEOF THE COLLAGENASEFAMILY (Methanopyruskandleri) |
PF01136(Peptidase_U32) | 5 | VAL A 179ARG A 209LEU A 36ILE A 173ASP A 177 | NoneNoneACT A 302 (-3.9A)ACT A 302 (-3.8A)None | 1.28A | 1t6zB-5d88A:undetectable | 1t6zB-5d88A:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e4s | CONTACTIN-4 (Mus musculus) |
PF00041(fn3) | 5 | THR A 750VAL A 777GLU A 774LEU A 716ILE A 718 | None | 1.37A | 1t6zB-5e4sA:undetectable | 1t6zB-5e4sA:24.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ekz | TRANSLATIONALACTIVATOR OFCYTOCHROME C OXIDASE1 (Mus musculus) |
PF01709(Transcrip_reg) | 5 | VAL A 289VAL A 286TYR A 283LEU A 165ILE A 161 | None | 1.44A | 1t6zB-5ekzA:undetectable | 1t6zB-5ekzA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ep1 | PUTATIVE REPRESSORPROTEIN LUXO (Photobacteriumangustum) |
PF00158(Sigma54_activat) | 5 | VAL A 346VAL A 378GLU A 351LEU A 362ILE A 366 | None | 1.29A | 1t6zB-5ep1A:undetectable | 1t6zB-5ep1A:21.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fo1 | RIBOFLAVINBIOSYNTHESIS PROTEINRIBF (Corynebacteriumammoniagenes) |
PF01687(Flavokinase)PF06574(FAD_syn) | 5 | VAL A 224GLU A 268ARG A 292LEU A 303ASP A 310 | None | 0.65A | 1t6zB-5fo1A:27.2 | 1t6zB-5fo1A:33.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw5 | T-COMPLEX PROTEIN 1SUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00118(Cpn60_TCP1) | 5 | THR a 333VAL a 295VAL a 242LEU a 224ILE a 374 | None | 1.08A | 1t6zB-5gw5a:undetectable | 1t6zB-5gw5a:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iz5 | CYTOSOLICPHOSPHOLIPASE A2DELTA (Homo sapiens) |
no annotation | 5 | VAL B 28TYR B 46GLU B 30LEU B 34ILE B 92 | None | 1.35A | 1t6zB-5iz5B:undetectable | 1t6zB-5iz5B:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jx3 | URACIL-DNAGLYCOSYLASE (Vaccinia virus) |
no annotation | 5 | VAL A 116VAL A 64TYR A 156LEU A 202ILE A 198 | None | 1.16A | 1t6zB-5jx3A:undetectable | 1t6zB-5jx3A:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l6m | RIBONUCLEASE VAPC (Caulobactervibrioides) |
PF01850(PIN) | 5 | VAL B 9VAL B 110TYR B 3LEU B 66ILE B 31 | NoneNoneNoneMLI A 101 (-4.5A)MLI A 101 (-4.3A) | 1.36A | 1t6zB-5l6mB:undetectable | 1t6zB-5l6mB:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l8v | DNA REPAIR ANDRECOMBINATIONPROTEIN RADA (Pyrococcusfuriosus) |
PF08423(Rad51) | 5 | THR A 310VAL A 237VAL A 279GLU A 135LEU A 261 | None | 0.89A | 1t6zB-5l8vA:undetectable | 1t6zB-5l8vA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqp | GLYCOSIDE HYDROLASEBT_1002 (Bacteroidesthetaiotaomicron) |
no annotation | 5 | VAL A 509VAL A 527ASN A 512GLU A 479ILE A 468 | None | 1.31A | 1t6zB-5mqpA:undetectable | 1t6zB-5mqpA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n9x | ADENYLATION DOMAIN (Streptomycessp.) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | VAL A 116VAL A 96TYR A 95LEU A 60ILE A 88 | None | 1.36A | 1t6zB-5n9xA:2.5 | 1t6zB-5n9xA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t6o | POLY-BETA-HYDROXYBUTERATE POLYMERASE (Cupriavidusnecator) |
PF07167(PhaC_N) | 5 | THR A 472VAL A 325VAL A 315LEU A 465ILE A 468 | None | 1.43A | 1t6zB-5t6oA:undetectable | 1t6zB-5t6oA:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vm2 | ALCOHOLDEHYDROGENASE (Escherichiacoli) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | THR A 145VAL A 71VAL A 87GLU A 34ASP A 85 | None | 1.28A | 1t6zB-5vm2A:2.0 | 1t6zB-5vm2A:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vmk | BIFUNCTIONAL PROTEINGLMU (Acinetobacterbaumannii) |
PF00132(Hexapep)PF12804(NTP_transf_3)PF14602(Hexapep_2) | 5 | THR A 110VAL A 103GLU A 219GLU A 221ILE A 169 | None | 1.36A | 1t6zB-5vmkA:2.6 | 1t6zB-5vmkA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yk7 | MITOCHONDRIALDISTRIBUTION ANDMORPHOLOGY PROTEIN12 (Saccharomycescerevisiae) |
no annotation | 5 | THR B 60GLU B 58GLU B 124LEU B 180ILE B 167 | None | 1.24A | 1t6zB-5yk7B:undetectable | 1t6zB-5yk7B:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ywo | 2F2 HEAVY CHAIN (Mus musculus) |
no annotation | 5 | VAL N 116GLU N 10LEU N 81ILE N 83ASP N 90 | None | 1.44A | 1t6zB-5ywoN:undetectable | 1t6zB-5ywoN:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6au1 | PUTATIVE HEMINSTORAGE PROTEIN (Bordetellabronchiseptica) |
no annotation | 5 | THR A 397VAL A 357VAL A 401LEU A 342ILE A 346 | None | 1.06A | 1t6zB-6au1A:undetectable | 1t6zB-6au1A:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6beg | SCAFFOLD PROTEIN D13 (Vaccinia virus) |
no annotation | 5 | THR A 259VAL A 505VAL A 527TYR A 258GLU A 444 | None | 1.34A | 1t6zB-6begA:undetectable | 1t6zB-6begA:undetectable |