SIMILAR PATTERNS OF AMINO ACIDS FOR 1T6Z_A_RBFA296_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 VAL A 547
VAL A 544
GLU A 539
GLU A 549
LEU A 556
 None
 1.47A 1t6zA-1dgsA:
undetectable		 1t6zA-1dgsA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dot DUCK OVOTRANSFERRIN

(Anas
platyrhynchos) 		PF00405
(Transferrin) 		5 THR A  11
VAL A 252
GLU A  16
GLU A  80
LEU A 284
 None
 1.46A 1t6zA-1dotA:
undetectable		 1t6zA-1dotA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 THR A 196
VAL A 115
ASN A 161
GLU A 199
GLU A 202
 None
 1.04A 1t6zA-1eovA:
undetectable		 1t6zA-1eovA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)

(Archaeoglobus
fulgidus) 		PF01656
(CbiA) 		5 VAL A   2
GLU A 135
LEU A  27
ILE A 113
ASP A 112
 None
 1.37A 1t6zA-1hyqA:
undetectable		 1t6zA-1hyqA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2

(Escherichia
coli) 		PF02222
(ATP-grasp) 		5 VAL A  70
VAL A  41
GLU A  72
LEU A  99
ILE A  79
 None
 1.46A 1t6zA-1kj9A:
3.8		 1t6zA-1kj9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 THR A  41
VAL A 110
ASN A 112
GLU A 175
ILE A 117
 None
 1.38A 1t6zA-1kwmA:
1.3		 1t6zA-1kwmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 VAL A 374
VAL A 318
ARG A 373
ILE A 232
ASP A 369
 MTL  A5600 (-3.6A)
None
MTL  A5600 ( 3.1A)
MTL  A5600 (-4.5A)
None
 1.16A 1t6zA-1m2wA:
1.5		 1t6zA-1m2wA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n07 PUTATIVE RIBOFLAVIN
KINASE

(Schizosaccharomyces
pombe) 		PF01687
(Flavokinase) 		8 THR A  45
VAL A  64
VAL A  79
GLU A  96
ARG A 121
LEU A 132
ILE A 136
ASP A 139
 FMN  A 165 (-4.4A)
FMN  A 165 (-4.3A)
FMN  A 165 ( 4.3A)
FMN  A 165 ( 2.8A)
FMN  A 165 (-2.9A)
FMN  A 165 (-4.5A)
FMN  A 165 ( 4.4A)
FMN  A 165 (-4.7A)
 0.66A 1t6zA-1n07A:
8.5		 1t6zA-1n07A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny1 PROBABLE
POLYSACCHARIDE
DEACETYLASE PDAA

(Bacillus
subtilis) 		PF01522
(Polysacc_deac_1) 		5 VAL A  99
VAL A 104
ASN A  74
GLU A  77
LEU A  85
 None
 1.26A 1t6zA-1ny1A:
undetectable		 1t6zA-1ny1A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4m RIBOFLAVIN KINASE

(Homo sapiens) 		PF01687
(Flavokinase) 		8 THR A  34
VAL A  69
GLU A  86
ARG A 111
GLU A 113
LEU A 122
ILE A 126
ASP A 129
 MG  A 201 (-3.2A)
FMN  A 401 (-4.6A)
FMN  A 401 (-2.9A)
FMN  A 401 (-2.6A)
None
FMN  A 401 ( 4.7A)
FMN  A 401 ( 4.3A)
FMN  A 401 (-4.4A)
 0.97A 1t6zA-1p4mA:
7.9		 1t6zA-1p4mA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4m RIBOFLAVIN KINASE

(Homo sapiens) 		PF01687
(Flavokinase) 		7 THR A  34
VAL A  69
GLU A  86
ARG A 111
GLU A 113
LYS A 114
ASP A 129
 MG  A 201 (-3.2A)
FMN  A 401 (-4.6A)
FMN  A 401 (-2.9A)
FMN  A 401 (-2.6A)
None
None
FMN  A 401 (-4.4A)
 1.47A 1t6zA-1p4mA:
7.9		 1t6zA-1p4mA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 THR A 255
VAL A 272
VAL A 274
ARG A 289
ASP A 290
 None
 1.37A 1t6zA-1ry2A:
2.2		 1t6zA-1ry2A:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		9 THR A 180
VAL A 197
ASN A 215
GLU A 231
ARG A 255
LYS A 258
LEU A 266
ILE A 270
ASP A 273
 ADP  A 294 (-3.7A)
None
None
None
None
None
None
None
None
 0.79A 1t6zA-1t6xA:
40.4		 1t6zA-1t6xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		10 THR A 180
VAL A 197
VAL A 213
GLU A 231
ARG A 255
GLU A 257
LYS A 258
LEU A 266
ILE A 270
ASP A 273
 ADP  A 294 (-3.7A)
None
None
None
None
None
None
None
None
None
 0.49A 1t6zA-1t6xA:
40.4		 1t6zA-1t6xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 VAL A  75
VAL A  32
GLU A  35
GLU A  38
ILE A  29
 None
 1.16A 1t6zA-1w1kA:
undetectable		 1t6zA-1w1kA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		5 VAL B 223
ASN B 369
GLU B  73
LEU B  53
ILE B 367
 None
 1.42A 1t6zA-1wdwB:
2.4		 1t6zA-1wdwB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI

(Homo sapiens) 		PF00106
(adh_short) 		5 THR A 209
VAL A  34
VAL A 113
GLU A  32
LEU A 246
 None
 1.30A 1t6zA-1yb1A:
2.4		 1t6zA-1yb1A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 GLU A 240
ARG A 178
GLU A 168
ILE A 173
ASP A 176
 None
 1.12A 1t6zA-1zg4A:
undetectable		 1t6zA-1zg4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a87 THIOREDOXIN
REDUCTASE

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		5 VAL A  93
VAL A  96
GLU A  91
LEU A  41
ILE A  18
 FAD  A 348 (-4.1A)
None
None
None
None
 0.76A 1t6zA-2a87A:
undetectable		 1t6zA-2a87A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		5 ARG A 265
GLU A 353
LEU A  33
ILE A 360
ASP A 357
 None
 1.15A 1t6zA-2aeuA:
undetectable		 1t6zA-2aeuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2x INTEGRIN ALPHA-1

(Rattus
norvegicus) 		PF00092
(VWA) 		5 VAL A 328
VAL A 325
ARG A 175
GLU A 333
ASP A 171
 None
 1.42A 1t6zA-2b2xA:
undetectable		 1t6zA-2b2xA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		5 VAL A 861
VAL A 101
ARG A 103
LEU A 867
ILE A 866
 None
 1.30A 1t6zA-2btvA:
undetectable		 1t6zA-2btvA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		5 VAL A 261
GLU A 253
ARG A 171
GLU A 262
ASP A 268
 None
 1.41A 1t6zA-2h1nA:
undetectable		 1t6zA-2h1nA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqy CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF09924
(DUF2156) 		5 THR A 187
GLU A 190
GLU A 268
LEU A 275
ILE A 272
 COA  A1001 (-4.8A)
COA  A1001 (-3.2A)
None
COA  A1001 ( 4.7A)
COA  A1001 (-4.7A)
 1.40A 1t6zA-2hqyA:
undetectable		 1t6zA-2hqyA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixd LMBE-RELATED PROTEIN

(Bacillus cereus) 		PF02585
(PIG-L) 		5 VAL A 198
GLU A  17
ARG A 201
GLU A 215
ILE A 149
 None
 1.07A 1t6zA-2ixdA:
4.2		 1t6zA-2ixdA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ki8 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE,
SUBUNIT D (FWDD-2)

(Archaeoglobus
fulgidus) 		PF01568
(Molydop_binding) 		5 VAL A  75
VAL A  28
GLU A 128
LEU A  67
ILE A  57
 None
 1.49A 1t6zA-2ki8A:
undetectable		 1t6zA-2ki8A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8x LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa) 		PF04390
(LptE) 		5 THR A  48
VAL A 119
ASN A  98
GLU A  76
ASP A 147
 None
 1.10A 1t6zA-2n8xA:
undetectable		 1t6zA-2n8xA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE

(Lactobacillus
plantarum) 		PF01643
(Acyl-ACP_TE) 		5 VAL A 212
VAL A 241
GLU A 209
LEU A 187
ILE A 239
 None
 1.34A 1t6zA-2ownA:
undetectable		 1t6zA-2ownA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 THR A 319
GLU A  37
LEU A 381
ILE A 377
ASP A 376
 None
 1.42A 1t6zA-2ox4A:
undetectable		 1t6zA-2ox4A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poz PUTATIVE DEHYDRATASE

(Mesorhizobium
japonicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 344
GLU A  36
GLU A 345
LEU A 370
ILE A 375
 None
 1.24A 1t6zA-2pozA:
undetectable		 1t6zA-2pozA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2

(Mus musculus) 		PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N) 		5 THR A 154
VAL A 182
VAL A  61
LEU A 207
ILE A 185
 None
 1.31A 1t6zA-2qptA:
undetectable		 1t6zA-2qptA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxy CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 THR A 160
VAL A 194
VAL A 131
LEU A 261
ILE A 311
 None
 1.46A 1t6zA-2vxyA:
2.2		 1t6zA-2vxyA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 5 VAL A 261
GLU A 253
ARG A 171
GLU A 262
ASP A 268
 None
 1.42A 1t6zA-3ahmA:
undetectable		 1t6zA-3ahmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bnw RIBOFLAVIN KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01687
(Flavokinase) 		6 VAL A  51
GLU A  92
ARG A 117
LEU A 128
ILE A 132
ASP A 135
 None
 0.97A 1t6zA-3bnwA:
7.5		 1t6zA-3bnwA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3k ALANINE RACEMASE

(Actinobacillus
succinogenes) 		PF13377
(Peripla_BP_3) 		5 VAL A 115
VAL A 217
GLU A 113
LEU A 150
ILE A 127
 None
 1.42A 1t6zA-3c3kA:
3.7		 1t6zA-3c3kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 THR A 118
ARG A  37
LEU A  44
ILE A  53
ASP A 256
 None
SO4  A4637 (-3.8A)
None
None
None
 1.11A 1t6zA-3eluA:
undetectable		 1t6zA-3eluA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		5 THR A 118
ARG A  38
LEU A  45
ILE A  53
ASP A 257
 None
SO4  A 268 (-3.9A)
None
None
None
 1.10A 1t6zA-3gczA:
undetectable		 1t6zA-3gczA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfn ASL2047 PROTEIN

(Nostoc sp. PCC
7120) 		PF17209
(Hfq) 		5 THR A  57
VAL A  25
VAL A  39
GLU A  26
LEU A  29
 None
 1.26A 1t6zA-3hfnA:
undetectable		 1t6zA-3hfnA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hk0 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 10

(Homo sapiens) 		PF00169
(PH)
PF00788
(RA) 		5 THR A 265
VAL A 241
VAL A 254
ARG A 319
GLU A 243
 None
 1.09A 1t6zA-3hk0A:
undetectable		 1t6zA-3hk0A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwu SERINE PROTEASE
HTRA1

(Homo sapiens) 		PF13365
(Trypsin_2) 		5 VAL A 333
VAL A 280
ASN A 334
GLU A 277
GLU A 338
 None
 1.15A 1t6zA-3nwuA:
2.2		 1t6zA-3nwuA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 THR A 207
VAL A 223
GLU A 255
ARG A 279
ASP A 297
 None
 0.48A 1t6zA-3op1A:
25.3		 1t6zA-3op1A:
30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 THR A 246
VAL A 194
VAL A 211
ASN A 209
GLU A 255
 None
 1.23A 1t6zA-3op1A:
25.3		 1t6zA-3op1A:
30.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		5 THR A 311
VAL A  90
GLU A 262
ARG A 455
LEU A 179
 None
 1.13A 1t6zA-3sfwA:
undetectable		 1t6zA-3sfwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tau GUANYLATE KINASE

(Listeria
monocytogenes) 		PF00625
(Guanylate_kin) 		5 THR A  84
GLU A  91
LEU A  93
ILE A  99
ASP A  34
 None
 1.47A 1t6zA-3tauA:
undetectable		 1t6zA-3tauA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuu ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		5 VAL A 317
ASN A 313
GLU A 231
GLU A 312
ILE A 271
 None
 1.20A 1t6zA-3vuuA:
undetectable		 1t6zA-3vuuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuv ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		5 VAL A 317
ASN A 313
GLU A 231
GLU A 312
ILE A 271
 None
 1.26A 1t6zA-3vuvA:
undetectable		 1t6zA-3vuvA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbb DIAMINOPIMELATE
DEHYDROGENASE

(Symbiobacterium
thermophilum) 		PF01408
(GFO_IDH_MocA)
PF16654
(DAPDH_C) 		5 VAL A 229
GLU A 232
LEU A 133
ILE A 129
ASP A 126
 None
GOL  A 302 ( 4.7A)
None
None
None
 1.19A 1t6zA-3wbbA:
undetectable		 1t6zA-3wbbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		5 VAL A 314
ASN A 315
GLU A 273
LEU A  66
ILE A 327
 None
 1.13A 1t6zA-3wrtA:
undetectable		 1t6zA-3wrtA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxy SUBTILISIN-LIKE
PROTEIN

(Prochloron
didemni) 		PF00082
(Peptidase_S8) 		5 VAL A 137
VAL A 168
GLU A 106
LEU A  22
ILE A 118
 None
 1.27A 1t6zA-3zxyA:
undetectable		 1t6zA-3zxyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b62 TSSL1

(Pseudomonas
aeruginosa) 		PF00691
(OmpA) 		5 VAL A 321
VAL A 323
GLU A 338
LEU A 355
ILE A 358
 None
 1.32A 1t6zA-4b62A:
undetectable		 1t6zA-4b62A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
mazei) 		PF01458
(UPF0051) 		5 THR A 285
ASN A 309
GLU A 337
LEU A 345
ILE A 343
 None
 1.44A 1t6zA-4dn7A:
undetectable		 1t6zA-4dn7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf2 ERYTHROCYTE BINDING
ANTIGEN 140

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		5 VAL A 593
ASN A 589
GLU A 588
LEU A 564
ILE A 546
 None
 1.26A 1t6zA-4gf2A:
undetectable		 1t6zA-4gf2A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		5 GLU A  41
ARG A 234
GLU A  20
ILE A  37
ASP A   7
 None
 1.42A 1t6zA-4gk8A:
undetectable		 1t6zA-4gk8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 VAL A 709
VAL A 670
GLU A 665
GLU A 711
LYS A 712
 None
 1.45A 1t6zA-4hwtA:
undetectable		 1t6zA-4hwtA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		5 THR A 311
VAL A  90
GLU A 262
ARG A 455
LEU A 179
 THR  A 311 ( 0.8A)
VAL  A  90 ( 0.6A)
GLU  A 262 ( 0.6A)
ARG  A 455 ( 0.6A)
LEU  A 179 ( 0.5A)
 1.11A 1t6zA-4kqnA:
undetectable		 1t6zA-4kqnA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		5 VAL A1708
ARG A1628
LEU A1633
ILE A1701
ASP A1706
 None
 1.34A 1t6zA-4p1tA:
undetectable		 1t6zA-4p1tA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		5 THR A 258
VAL A 272
ASN A 455
GLU A 486
ILE A 453
 None
 1.49A 1t6zA-4repA:
2.5		 1t6zA-4repA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trt DNA POLYMERASE III
SUBUNIT BETA

(Deinococcus
radiodurans) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 THR A  38
VAL A   6
VAL A  58
GLU A  88
LEU A  96
 None
 0.93A 1t6zA-4trtA:
undetectable		 1t6zA-4trtA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ttw CENTRIOLE PROTEIN

(Chlamydomonas
reinhardtii) 		PF16531
(SAS-6_N) 		5 VAL A  29
VAL A  31
GLU A 111
LEU A 109
ILE A 139
 None
 1.37A 1t6zA-4ttwA:
undetectable		 1t6zA-4ttwA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 VAL A 247
VAL A 266
GLU A 307
LEU A 301
ILE A  99
 None
 1.46A 1t6zA-4xixA:
undetectable		 1t6zA-4xixA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 5 THR A 116
ASN A 318
GLU A 295
ILE A 324
ASP A 325
 ST9  A 403 (-4.2A)
None
None
None
None
 1.45A 1t6zA-4zyoA:
undetectable		 1t6zA-4zyoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase) 		6 THR A 208
VAL A 224
GLU A 268
ARG A 292
LEU A 303
ASP A 310
 FMN  A 339 (-3.2A)
FMN  A 339 (-4.4A)
FMN  A 339 (-3.2A)
FMN  A 339 (-2.9A)
FMN  A 339 (-4.9A)
FMN  A 339 (-4.4A)
 0.56A 1t6zA-5a89A:
5.4		 1t6zA-5a89A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 VAL B  89
VAL B 138
GLU B  87
LEU B 105
ILE B 112
 None
 1.30A 1t6zA-5a8rB:
undetectable		 1t6zA-5a8rB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		5 THR A  78
VAL A  75
LEU A 194
ILE A  10
ASP A  41
 None
 1.29A 1t6zA-5c54A:
undetectable		 1t6zA-5c54A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d88 PREDICTED PROTEASE
OF THE COLLAGENASE
FAMILY

(Methanopyrus
kandleri) 		PF01136
(Peptidase_U32) 		5 VAL A 179
ARG A 209
LEU A  36
ILE A 173
ASP A 177
 None
None
ACT  A 302 (-3.9A)
ACT  A 302 (-3.8A)
None
 1.36A 1t6zA-5d88A:
undetectable		 1t6zA-5d88A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9q GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		5 THR A 118
VAL A 255
ARG A  38
LEU A  45
ASP A 254
 None
 1.37A 1t6zA-5e9qA:
undetectable		 1t6zA-5e9qA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 THR A 462
VAL A 479
VAL A 435
GLU A 460
ILE A 475
 None
 1.37A 1t6zA-5elxA:
undetectable		 1t6zA-5elxA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f89 CAP248-2B LIGHT
CHAIN

(Homo sapiens) 		no annotation 5 THR L 162
VAL L 196
VAL L 145
GLU L 204
LYS L 205
 None
 1.48A 1t6zA-5f89L:
undetectable		 1t6zA-5f89L:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 VAL A  28
ASN A 127
LEU A 106
ILE A  96
ASP A  30
 None
 1.45A 1t6zA-5fbzA:
undetectable		 1t6zA-5fbzA:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 VAL A 224
GLU A 268
ARG A 292
LEU A 303
ASP A 310
 None
 0.72A 1t6zA-5fo1A:
26.5		 1t6zA-5fo1A:
33.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsi BACTERIORHODOPSIN

(Candidatus
Actinomarina
minuta) 		PF01036
(Bac_rhodopsin) 		5 THR A  88
VAL A  98
VAL A  82
GLU A 146
GLU A  96
 None
 1.33A 1t6zA-5jsiA:
undetectable		 1t6zA-5jsiA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 THR A 225
VAL A 242
VAL A 244
ARG A 258
ASP A 259
 None
 1.29A 1t6zA-5k8fA:
2.7		 1t6zA-5k8fA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		no annotation 5 THR A  71
GLU A  70
LEU A   9
ILE A  52
ASP A  57
 None
 1.36A 1t6zA-5lj6A:
undetectable		 1t6zA-5lj6A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 5 VAL A 509
VAL A 527
ASN A 512
GLU A 479
ILE A 468
 None
 1.30A 1t6zA-5mqpA:
undetectable		 1t6zA-5mqpA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 5 VAL A 530
ASN A 478
GLU A 525
GLU A 418
ILE A 484
 None
None
BMA  A1134 (-3.6A)
None
None
 1.47A 1t6zA-5nbsA:
undetectable		 1t6zA-5nbsA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 VAL A 440
VAL A 438
ASN A 241
GLU A 442
LEU A 286
 None
None
None
ZN  A 601 (-2.6A)
None
 0.98A 1t6zA-5oltA:
undetectable		 1t6zA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0r DH270.UCA1 LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR L 166
VAL L 199
VAL L 148
LYS L 208
LEU L 139
 None
 1.49A 1t6zA-5u0rL:
undetectable		 1t6zA-5u0rL:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2o J30 CCH

(Thermobacillus
composti) 		no annotation 5 VAL A 221
VAL A 138
GLU A 203
ARG A 239
ASP A 118
 None
 1.13A 1t6zA-5u2oA:
undetectable		 1t6zA-5u2oA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uth THIOREDOXIN
REDUCTASE

(Mycolicibacterium
smegmatis) 		PF07992
(Pyr_redox_2) 		5 VAL A  86
VAL A  89
GLU A  84
LEU A  34
ILE A  11
 FAD  A 400 (-4.1A)
None
None
None
None
 0.86A 1t6zA-5uthA:
undetectable		 1t6zA-5uthA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		5 VAL A 449
ASN A 487
ARG A 405
GLU A 489
ASP A 403
 None
 1.31A 1t6zA-5wu3A:
undetectable		 1t6zA-5wu3A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		5 VAL A 449
ASN A 487
ARG A 405
GLU A 489
ASP A 403
 None
 1.34A 1t6zA-5wu6A:
undetectable		 1t6zA-5wu6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y PROBABLE ATP-BINDING
COMPONENT OF ABC
TRANSPORTER

(Pseudomonas
aeruginosa) 		no annotation 5 GLU B 124
GLU B 116
LYS B 115
LEU B 103
ILE B  99
 None
 1.50A 1t6zA-5x5yB:
undetectable		 1t6zA-5x5yB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g43 PUTATIVE MAJOR
CAPSID PROTEIN

(Cafeteriavirus-dependent
mavirus) 		no annotation 5 VAL A 448
VAL A 468
GLU A 356
LEU A 374
ILE A 422
 None
 1.28A 1t6zA-6g43A:
undetectable		 1t6zA-6g43A:
13.68