SIMILAR PATTERNS OF AMINO ACIDS FOR 1T46_A_STIA3

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
LYS A 222
GLU A 236
VAL A 249
THR A 266
GLY A 272
LEU A 321
 None
 0.52A 1t46A-1k9aA:
31.6		 1t46A-1k9aA:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
VAL A 318
THR A 334
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.42A 1t46A-1opkA:
30.7		 1t46A-1opkA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		8 LEU A 164
VAL A 172
ALA A 185
GLU A 202
LEU A 206
GLY A 250
LEU A 301
ASP A 550
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
None
ADP  A 810 (-4.7A)
ADP  A 810 ( 3.0A)
 1.04A 1t46A-1q8yA:
21.1		 1t46A-1q8yA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		8 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
LEU A 206
GLY A 250
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
None
ADP  A 810 (-4.7A)
 0.92A 1t46A-1q8yA:
21.1		 1t46A-1q8yA:
23.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
GLY A 697
LEU A 818
ASP A 829
 None
 0.64A 1t46A-1rjbA:
40.4		 1t46A-1rjbA:
58.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
VAL A 352
ALA A 367
GLU A 386
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.54A 1t46A-1u59A:
31.4		 1t46A-1u59A:
35.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
VAL A  68
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.8A)
None
HYM  A 400 (-4.5A)
 0.57A 1t46A-1zltA:
21.0		 1t46A-1zltA:
27.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU X  17
VAL X  25
ALA X  37
LYS X  39
GLU X  54
VAL X  67
THR X  82
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.52A 1t46A-2dq7X:
31.6		 1t46A-2dq7X:
36.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 162
VAL A 170
ALA A 184
LYS A 186
GLU A 201
LEU A 205
VAL A 220
LEU A 290
 None
 0.77A 1t46A-2eu9A:
22.3		 1t46A-2eu9A:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
VAL A 301
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.90A 1t46A-2hk5A:
25.0		 1t46A-2hk5A:
38.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
VAL A 301
THR A 316
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.84A 1t46A-2hk5A:
25.0		 1t46A-2hk5A:
38.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 248
VAL A 256
ALA A 269
LYS A 271
GLU A 286
VAL A 299
THR A 315
GLY A 321
LEU A 370
ASP A 381
PHE A 382
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
GIN  A 600 (-4.0A)
 0.70A 1t46A-2hz0A:
32.5		 1t46A-2hz0A:
36.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		8 VAL A 436
ALA A 452
LYS A 454
GLU A 471
VAL A 484
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.74A 1t46A-2j0jA:
33.6		 1t46A-2j0jA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 436
ALA A 452
LYS A 454
GLU A 471
VAL A 484
GLY A 505
LEU A 553
ASP A 564
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
None
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
None
 0.73A 1t46A-2jkmA:
32.4		 1t46A-2jkmA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
LYS A 273
GLU A 288
THR A 316
GLY A 322
LEU A 371
ASP A 382
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.83A 1t46A-2og8A:
31.4		 1t46A-2og8A:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
LYS A 273
GLU A 288
VAL A 301
THR A 316
GLY A 322
LEU A 371
ASP A 382
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.53A 1t46A-2og8A:
31.4		 1t46A-2og8A:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
ALA A 271
LYS A 273
GLU A 288
VAL A 301
THR A 316
GLY A 322
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 3.3A)
 0.65A 1t46A-2og8A:
31.4		 1t46A-2og8A:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
THR A 316
GLY A 322
ASP A 382
PHE A 383
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 1.06A 1t46A-2og8A:
31.4		 1t46A-2og8A:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 588
VAL A 596
ALA A 614
LYS A 616
GLU A 633
VAL A 647
THR A 663
GLY A 669
LEU A 785
ASP A 796
 None
 0.68A 1t46A-2ogvA:
26.9		 1t46A-2ogvA:
68.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  90
ALA A 103
LYS A 105
GLU A 124
VAL A 137
GLY A 159
LEU A 205
ASP A 216
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 (-4.7A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 1.07A 1t46A-2v55A:
18.5		 1t46A-2v55A:
23.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
LYS A 222
GLU A 236
VAL A 249
THR A 266
GLY A 272
LEU A 321
 None
 0.53A 1t46A-3d7uA:
26.0		 1t46A-3d7uA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
LEU A 882
VAL A 892
GLY A 915
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
None
None
8ST  A2001 ( 3.7A)
 0.61A 1t46A-3hngA:
41.9		 1t46A-3hngA:
48.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		8 LEU A 680
VAL A 689
ALA A 700
LYS A 702
GLU A 715
LEU A 719
LEU A 804
ASP A 828
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 0.96A 1t46A-3lj0A:
22.2		 1t46A-3lj0A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		8 VAL A 566
ALA A 579
LYS A 581
GLU A 596
LEU A 600
GLY A 634
LEU A 684
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
ANP  A 877 (-2.9A)
 0.96A 1t46A-3lltA:
21.3		 1t46A-3lltA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		8 VAL A 566
ALA A 579
LYS A 581
GLU A 596
LEU A 600
VAL A 614
GLY A 634
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
ANP  A 877 (-2.9A)
 0.79A 1t46A-3lltA:
21.3		 1t46A-3lltA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.58A 1t46A-3mdyA:
25.5		 1t46A-3mdyA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
LEU A  95
VAL A 104
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
None
XFE  A 351 (-4.6A)
 0.75A 1t46A-3mvjA:
21.5		 1t46A-3mvjA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 VAL A  37
ALA A  49
LYS A  51
GLU A  69
LEU A  73
VAL A  82
LEU A 151
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
None
ADP  A 314 (-4.6A)
MG  A 312 ( 3.3A)
 0.87A 1t46A-3nizA:
23.1		 1t46A-3nizA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  88
VAL A  96
ALA A 109
LYS A 111
GLU A 130
GLY A 165
LEU A 212
ASP A 223
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
None
None
SO4  A   5 ( 4.5A)
 0.78A 1t46A-3nuuA:
23.1		 1t46A-3nuuA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
ALA A 213
GLU A 234
LEU A 238
VAL A 247
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
None
None
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 1.02A 1t46A-3nyoA:
21.4		 1t46A-3nyoA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		9 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
None
AMP  A 577 (-4.8A)
 0.75A 1t46A-3nyoA:
21.4		 1t46A-3nyoA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
LEU A 119
THR A 144
GLY A 150
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
None
 0.86A 1t46A-3q5iA:
19.9		 1t46A-3q5iA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  63
VAL A  71
ALA A  84
LYS A  86
LEU A 119
THR A 144
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
 0.75A 1t46A-3q5iA:
19.9		 1t46A-3q5iA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
 0.58A 1t46A-3tt0A:
34.2		 1t46A-3tt0A:
42.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
LEU A 407
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
 0.70A 1t46A-3txoA:
13.5		 1t46A-3txoA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 899
GLY A 922
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.81A 1t46A-3vidA:
36.2		 1t46A-3vidA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
VAL A 899
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-3.7A)
 0.66A 1t46A-3vidA:
36.2		 1t46A-3vidA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 899
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.46A 1t46A-3wzdA:
35.2		 1t46A-3wzdA:
53.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.62A 1t46A-3wzdA:
35.2		 1t46A-3wzdA:
53.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
VAL A 899
GLY A 922
LEU A1035
ASP A1046
PHE A1047
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 0.68A 1t46A-4agdA:
41.9		 1t46A-4agdA:
49.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  18
ALA A  31
LYS A  33
GLU A  51
LEU A  55
VAL A  64
LEU A 133
ASP A 144
 D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
None
None
D15  A 500 (-4.5A)
D15  A 500 (-3.7A)
 0.66A 1t46A-4aguA:
23.4		 1t46A-4aguA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A  91
ALA A 104
LYS A 106
GLU A 125
LEU A 129
GLY A 160
LEU A 208
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 ( 4.8A)
 0.54A 1t46A-4aw2A:
19.8		 1t46A-4aw2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		8 LEU A 246
VAL A 254
ALA A 267
LYS A 269
GLU A 288
LEU A 292
GLY A 324
LEU A 371
 None
 0.80A 1t46A-4c0tA:
22.6		 1t46A-4c0tA:
15.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 653
LYS A 655
GLU A 672
THR A 701
GLY A 707
LEU A 773
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-4.5A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 1.00A 1t46A-4ckrA:
33.7		 1t46A-4ckrA:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.93A 1t46A-4crsA:
20.9		 1t46A-4crsA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
VAL A 721
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
 0.72A 1t46A-4crsA:
20.9		 1t46A-4crsA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 (-3.5A)
 0.48A 1t46A-4eutA:
19.6		 1t46A-4eutA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
VAL A  68
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
None
BX7  A 401 (-3.3A)
 0.65A 1t46A-4euuA:
16.2		 1t46A-4euuA:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.88A 1t46A-4f4pA:
30.4		 1t46A-4f4pA:
35.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1122
VAL A1130
ALA A1148
LYS A1150
GLU A1167
VAL A1180
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.95A 1t46A-4fodA:
31.0		 1t46A-4fodA:
37.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 855
VAL A 863
ALA A 880
GLU A 898
LEU A 902
VAL A 911
GLY A 935
LEU A 983
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
None
None
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
 0.84A 1t46A-4gl9A:
21.9		 1t46A-4gl9A:
34.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 855
VAL A 863
ALA A 880
LYS A 882
GLU A 898
VAL A 911
GLY A 935
LEU A 983
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
 0.82A 1t46A-4gl9A:
21.9		 1t46A-4gl9A:
34.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 828
VAL A 836
ALA A 853
LYS A 855
GLU A 871
LEU A 875
VAL A 884
GLY A 908
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.60A 1t46A-4hviA:
23.7		 1t46A-4hviA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		7 LEU A 132
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 211
LEU A 259
 None
 0.58A 1t46A-4hzsA:
20.7		 1t46A-4hzsA:
34.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A  61
LYS A  63
GLU A  77
LEU A  81
VAL A  90
GLY A 110
LEU A 163
ASP A 175
 1UL  A 501 (-3.1A)
None
None
None
None
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 1.08A 1t46A-4l52A:
19.4		 1t46A-4l52A:
30.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A  50
ALA A  61
LYS A  63
GLU A  77
LEU A  81
VAL A  90
GLY A 110
LEU A 163
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
None
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
 0.67A 1t46A-4l52A:
19.4		 1t46A-4l52A:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		8 VAL A 205
ALA A 218
LYS A 220
GLU A 239
LEU A 243
VAL A 255
GLY A 277
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
None
29X  A 702 (-4.8A)
None
29X  A 702 (-4.6A)
 1.00A 1t46A-4mk0A:
21.4		 1t46A-4mk0A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL B  38
ALA B  51
LYS B  53
GLU B  70
LEU B  74
GLY B 105
LEU B 151
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.73A 1t46A-4o27B:
24.3		 1t46A-4o27B:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.72A 1t46A-4o38A:
20.9		 1t46A-4o38A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
VAL A 911
ALA A 928
GLU A 947
LEU A 951
GLY A 984
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.57A 1t46A-4oliA:
27.5		 1t46A-4oliA:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
GLY A 697
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.55A 1t46A-4rt7A:
34.5		 1t46A-4rt7A:
48.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
VAL A 247
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
SGV  A 601 (-4.9A)
 0.92A 1t46A-4tnbA:
20.0		 1t46A-4tnbA:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
VAL A  65
THR A  81
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.86A 1t46A-4ueuA:
31.5		 1t46A-4ueuA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
VAL A  65
THR A  81
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
 0.79A 1t46A-4ueuA:
31.5		 1t46A-4ueuA:
38.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		8 LEU A 104
ALA A 125
GLU A 146
LEU A 150
VAL A 159
GLY A 181
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.4A)
None
None
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 1.04A 1t46A-4wb7A:
21.4		 1t46A-4wb7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		9 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
LEU A 150
VAL A 159
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
None
ATP  A 501 (-4.5A)
 0.80A 1t46A-4wb7A:
21.4		 1t46A-4wb7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		9 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 239
VAL A 248
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.85A 1t46A-4wboA:
22.4		 1t46A-4wboA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		9 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 239
VAL A 248
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
None
ANW  A 601 (-4.9A)
None
 0.96A 1t46A-4wboA:
22.4		 1t46A-4wboA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 LEU B 267
VAL B 275
ALA B 288
LYS B 290
VAL B 318
THR B 334
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.78A 1t46A-4xeyB:
26.6		 1t46A-4xeyB:
29.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
GLY A 697
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.71A 1t46A-4xufA:
39.3		 1t46A-4xufA:
60.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
VAL A 416
ALA A 428
LYS A 430
VAL A 458
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.76A 1t46A-4y93A:
30.4		 1t46A-4y93A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 477
ALA A 488
LYS A 490
GLU A 509
LEU A 513
THR A 539
GLY A 545
LEU A 595
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
None
4CV  A 801 (-2.8A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
 0.75A 1t46A-4yffA:
25.5		 1t46A-4yffA:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		9 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 239
VAL A 248
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
None
AN2  A 601 (-3.0A)
 0.90A 1t46A-4yhjA:
20.3		 1t46A-4yhjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 VAL A 201
LYS A 216
GLU A 235
LEU A 239
VAL A 248
GLY A 270
LEU A 319
ASP A 330
 AN2  A 601 (-4.0A)
AN2  A 601 ( 3.9A)
None
None
None
None
None
AN2  A 601 (-3.0A)
 1.00A 1t46A-4yhjA:
20.3		 1t46A-4yhjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		9 LEU A  34
VAL A  42
ALA A  55
GLU A  76
LEU A  80
THR A 105
GLY A 111
LEU A 158
ASP A 172
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
ADP  A 506 ( 2.4A)
 0.94A 1t46A-4ysjA:
22.7		 1t46A-4ysjA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		9 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A  80
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.74A 1t46A-4ysjA:
22.7		 1t46A-4ysjA:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.49A 1t46A-5a46A:
27.9		 1t46A-5a46A:
43.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 258
ALA A 275
LYS A 277
GLU A 290
THR A 325
GLY A 331
LEU A 386
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
 0.57A 1t46A-5e8yA:
25.1		 1t46A-5e8yA:
28.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
LEU A 951
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.60A 1t46A-5f1zA:
28.5		 1t46A-5f1zA:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
VAL A 658
THR A 674
GLY A 680
LEU A 825
ASP A 836
PHE A 837
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.39A 1t46A-5grnA:
32.9		 1t46A-5grnA:
61.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		8 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
VAL A  74
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
ADP  A 301 (-4.7A)
 0.75A 1t46A-5hu3A:
23.2		 1t46A-5hu3A:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		8 VAL A  32
ALA A  45
LYS A  47
GLU A  65
VAL A  78
GLY A 100
LEU A 147
ASP A 161
 None
 1.05A 1t46A-5ig1A:
23.0		 1t46A-5ig1A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A 404
ALA A 417
LYS A 419
GLU A 436
LEU A 440
VAL A 449
GLY A 471
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 1.06A 1t46A-5jznA:
21.9		 1t46A-5jznA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 8 VAL A  25
ALA A  38
LYS A  40
GLU A  57
LEU A  61
GLY A  92
LEU A 139
ASP A 150
 7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
None
None
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
 1.01A 1t46A-5tvtA:
22.2		 1t46A-5tvtA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 106
ALA A 119
LYS A 121
GLU A 140
VAL A 153
GLY A 175
LEU A 221
ASP A 232
 None
 1.02A 1t46A-5u7qA:
19.3		 1t46A-5u7qA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 VAL A 205
ALA A 218
LYS A 220
GLU A 239
LEU A 243
VAL A 255
GLY A 277
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
QRW  A 601 (-3.9A)
None
None
None
None
 0.89A 1t46A-5uuuA:
21.8		 1t46A-5uuuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 8 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLU A 725
VAL A 738
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-4.1A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.53A 1t46A-5vilA:
24.4		 1t46A-5vilA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 8 VAL A 226
ALA A 237
LYS A 239
GLU A 259
LEU A 263
VAL A 272
GLY A 294
LEU A 347
 None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
None
None
DL1  A 601 ( 4.8A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
 0.92A 1t46A-6bfnA:
23.9		 1t46A-6bfnA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 8 ALA A 192
LYS A 194
GLU A 236
LEU A 240
VAL A 249
GLY A 273
LEU A 319
ASP A 330
 BI9  A 501 (-3.3A)
NH4  A 506 ( 4.4A)
NH4  A 506 (-3.0A)
None
None
BI9  A 501 (-3.3A)
BI9  A 501 (-4.7A)
None
 1.01A 1t46A-6bqlA:
21.8		 1t46A-6bqlA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 8 VAL A 179
ALA A 192
LYS A 194
GLU A 236
VAL A 249
GLY A 273
LEU A 319
ASP A 330
 BI9  A 501 ( 4.8A)
BI9  A 501 (-3.3A)
NH4  A 506 ( 4.4A)
NH4  A 506 (-3.0A)
None
BI9  A 501 (-3.3A)
BI9  A 501 (-4.7A)
None
 1.07A 1t46A-6bqlA:
21.8		 1t46A-6bqlA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 9 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
LEU A 929
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.72A 1t46A-6c7yA:
28.4		 1t46A-6c7yA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 9 LEU A 169
VAL A 177
ALA A 191
LYS A 193
GLU A 208
LEU A 212
GLY A 247
LEU A 297
ASP A 327
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
None
None
None
3NG  A 501 (-4.5A)
 0.99A 1t46A-6fylA:
22.4		 1t46A-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 9 LEU A 169
VAL A 177
ALA A 191
LYS A 193
GLU A 208
LEU A 212
VAL A 227
GLY A 247
ASP A 327
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
None
None
None
3NG  A 501 (-4.5A)
 0.83A 1t46A-6fylA:
22.4		 1t46A-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 8 LEU A 167
VAL A 175
ALA A 189
GLU A 206
LEU A 210
GLY A 245
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 1.27A 1t46A-6fyoA:
22.3		 1t46A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 8 LEU A 167
VAL A 175
ALA A 189
GLU A 206
LEU A 210
VAL A 225
GLY A 245
ASP A 325
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.4A)
None
None
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.6A)
 1.16A 1t46A-6fyoA:
22.3		 1t46A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 8 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
GLY A 245
LEU A 295
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
 1.10A 1t46A-6fyoA:
22.3		 1t46A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 8 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
VAL A 225
GLY A 245
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
None
EAQ  A 501 (-3.9A)
 0.91A 1t46A-6fyoA:
22.3		 1t46A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 9 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
GLY A 245
LEU A 295
ASP A 325
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
3NG  A 501 (-4.3A)
 1.07A 1t46A-6fyvA:
22.2		 1t46A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 9 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
VAL A 225
GLY A 245
ASP A 325
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
3NG  A 501 (-4.3A)
 0.90A 1t46A-6fyvA:
22.2		 1t46A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 VAL A 229
TYR A 110
ARG A 167
CYH A 158
 None
 1.24A 1t46A-1bxtA:
undetectable		 1t46A-1bxtA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 VAL A 164
VAL A 338
TYR A 603
ARG A 326
 None
None
None
PGD  A 783 ( 2.6A)
 1.30A 1t46A-1dmsA:
undetectable		 1t46A-1dmsA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3e ALCOHOL
DEHYDROGENASE, CLASS
II

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 201
CYH A  46
CYH A 215
CYH A 206
 None
ZN  A 378 (-2.5A)
None
None
 1.16A 1t46A-1e3eA:
undetectable		 1t46A-1e3eA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 VAL A1160
VAL A1149
TYR A1176
CYH A1175
 F43  A2570 (-3.8A)
None
None
None
 1.12A 1t46A-1e6yA:
undetectable		 1t46A-1e6yA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		4 VAL A 138
TYR A  42
CYH A  67
CYH A  80
 None
 1.22A 1t46A-1mxfA:
undetectable		 1t46A-1mxfA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py9 MYELIN-OLIGODENDROCY
TE GLYCOPROTEIN

(Mus musculus) 		PF07686
(V-set) 		4 VAL A  88
VAL A  48
TYR A  51
ARG A  13
 None
 1.27A 1t46A-1py9A:
undetectable		 1t46A-1py9A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ral 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		4 VAL A 265
VAL A   8
CYH A 193
CYH A 188
 None
 1.28A 1t46A-1ralA:
undetectable		 1t46A-1ralA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 693
CYH A 694
CYH A 807
CYH A 828
 None
 0.48A 1t46A-1rjbA:
40.4		 1t46A-1rjbA:
58.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pseudomonas sp.
ACP) 		PF00291
(PALP) 		4 VAL A 193
VAL A 258
ARG A  53
CYH A 196
 None
None
None
PLP  A 401 (-3.8A)
 1.22A 1t46A-1tzmA:
undetectable		 1t46A-1tzmA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		4 VAL A1504
VAL A1555
TYR A1527
ARG A1499
 None
 1.31A 1t46A-1ug3A:
undetectable		 1t46A-1ug3A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		4 VAL A 231
CYH A 303
CYH A 316
ARG A 320
 None
None
None
CL  A 800 (-4.2A)
 1.11A 1t46A-1xknA:
undetectable		 1t46A-1xknA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 VAL A 244
VAL A 135
TYR A 222
ARG A 207
 None
 1.21A 1t46A-2bihA:
undetectable		 1t46A-2bihA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 VAL A 244
VAL A 135
TYR A 222
ARG A 207
 None
 1.19A 1t46A-2biiA:
undetectable		 1t46A-2biiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hng HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF06619
(DUF1149) 		4 VAL A  57
VAL A  85
CYH A 103
ARG A 101
 None
 1.11A 1t46A-2hngA:
undetectable		 1t46A-2hngA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixd LMBE-RELATED PROTEIN

(Bacillus cereus) 		PF02585
(PIG-L) 		4 VAL A  92
VAL A 101
TYR A 105
ARG A  87
 None
 1.31A 1t46A-2ixdA:
undetectable		 1t46A-2ixdA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 661
TYR A 665
CYH A 666
CYH A 774
ARG A 777
 None
 1.08A 1t46A-2ogvA:
26.9		 1t46A-2ogvA:
68.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz6 VIRULENCE FACTOR
REGULATOR

(Pseudomonas
aeruginosa) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		4 VAL A 188
VAL A 201
CYH A 183
ARG A 179
 None
 1.28A 1t46A-2oz6A:
undetectable		 1t46A-2oz6A:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 562
TYR A 566
CYH A 622
ARG A 625
 None
None
None
SO4  A 303 ( 2.9A)
 1.29A 1t46A-2psqA:
34.3		 1t46A-2psqA:
43.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rui LPXTG-SITE
TRANSPEPTIDASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF04203
(Sortase) 		4 VAL A 110
VAL A  94
TYR A 148
ARG A 196
 None
 1.24A 1t46A-2ruiA:
undetectable		 1t46A-2ruiA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 VAL A  69
VAL A  83
TYR A 129
ARG A  32
 None
 0.96A 1t46A-2v7gA:
undetectable		 1t46A-2v7gA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vns METALLOREDUCTASE
STEAP3

(Homo sapiens) 		PF03807
(F420_oxidored) 		4 VAL A 165
VAL A 143
TYR A 132
ARG A  46
 None
 1.25A 1t46A-2vnsA:
undetectable		 1t46A-2vnsA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		4 VAL A 448
VAL A 247
ARG A 170
CYH A 426
 None
 1.10A 1t46A-2wsxA:
undetectable		 1t46A-2wsxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 VAL A  21
VAL A  28
TYR A   4
CYH A  51
 COA  A 760 (-4.6A)
None
None
None
 1.31A 1t46A-2x58A:
undetectable		 1t46A-2x58A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya3 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF16579
(AdenylateSensor) 		4 VAL A 427
CYH A 539
ARG A 436
CYH A 414
 None
 1.26A 1t46A-2ya3A:
undetectable		 1t46A-2ya3A:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 562
TYR A 566
CYH A 622
ARG A 625
 None
M33  A1996 ( 4.7A)
None
None
 1.24A 1t46A-3b2tA:
34.3		 1t46A-3b2tA:
48.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 VAL A 216
VAL A 252
ARG A 494
CYH A 587
 None
None
None
WCC  A 811 (-2.2A)
 1.04A 1t46A-3cf4A:
undetectable		 1t46A-3cf4A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpi RAB GDP-DISSOCIATION
INHIBITOR

(Saccharomyces
cerevisiae) 		PF00996
(GDI) 		4 VAL G  30
TYR G 296
ARG G 106
CYH G  22
 None
 1.23A 1t46A-3cpiG:
undetectable		 1t46A-3cpiG:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11)
PF14710
(Nitr_red_alph_N)
PF14711
(Nitr_red_bet_C) 		4 VAL B  36
TYR B 229
ARG A  38
CYH B 244
 None
SF4  B 804 (-4.5A)
None
SF4  B 803 (-2.2A)
 1.26A 1t46A-3egwB:
undetectable		 1t46A-3egwB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez6 PLASMID PARTITION
PROTEIN A

(Escherichia
coli) 		PF13614
(AAA_31) 		4 VAL A 197
VAL A 148
TYR A 109
ARG A 378
 None
 0.86A 1t46A-3ez6A:
undetectable		 1t46A-3ez6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjy PROBABLE MUTT1
PROTEIN

(Bifidobacterium
adolescentis) 		PF00293
(NUDIX)
PF00300
(His_Phos_1) 		4 VAL A 156
VAL A  16
TYR A  91
CYH A  93
 None
 1.29A 1t46A-3fjyA:
undetectable		 1t46A-3fjyA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 907
TYR A 911
CYH A 912
CYH A1039
 8ST  A2001 (-4.5A)
8ST  A2001 (-4.9A)
8ST  A2001 (-3.8A)
8ST  A2001 (-4.2A)
 0.38A 1t46A-3hngA:
41.9		 1t46A-3hngA:
48.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsi PHOSPHATIDYLSERINE
SYNTHASE

(Haemophilus
influenzae) 		PF13091
(PLDc_2) 		4 VAL A 367
VAL A 405
TYR A 172
CYH A 274
 None
 1.27A 1t46A-3hsiA:
undetectable		 1t46A-3hsiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		4 VAL A 294
TYR A 241
CYH A 245
CYH A 226
 None
None
None
FAD  A 371 (-3.1A)
 1.30A 1t46A-3if9A:
undetectable		 1t46A-3if9A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 VAL A 347
TYR A 337
CYH A 391
ARG A 300
 None
 0.98A 1t46A-3ksyA:
undetectable		 1t46A-3ksyA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n79 PDUT

(Salmonella
enterica) 		PF00936
(BMC) 		4 VAL A 140
VAL A  81
ARG A 167
CYH A 136
 None
 1.26A 1t46A-3n79A:
undetectable		 1t46A-3n79A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t32 AMINOTRANSFERASE,
CLASS I/II

(Bacillus
anthracis) 		PF00155
(Aminotran_1_2) 		4 VAL A 157
VAL A 123
TYR A 352
ARG A 221
 None
 1.12A 1t46A-3t32A:
undetectable		 1t46A-3t32A:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 914
CYH A 919
CYH A1024
CYH A1045
 None
4TT  A2001 (-4.3A)
None
None
 0.54A 1t46A-3vidA:
36.2		 1t46A-3vidA:
48.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 VAL A 139
VAL A 195
TYR A 187
CYH A 184
 OLC  A2008 (-4.6A)
None
None
None
 1.26A 1t46A-3vw7A:
undetectable		 1t46A-3vw7A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 VAL A 190
VAL A 177
TYR A  12
CYH A 110
 None
None
None
MG  A 403 (-4.6A)
 1.23A 1t46A-3w15A:
undetectable		 1t46A-3w15A:
23.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 914
CYH A 919
ARG A1027
CYH A1045
 None
LEV  A1201 (-4.1A)
None
GOL  A1210 ( 3.3A)
 0.87A 1t46A-3wzdA:
35.2		 1t46A-3wzdA:
53.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		4 VAL A 190
VAL A 270
ARG A 261
CYH A 164
 None
 1.19A 1t46A-3zdpA:
undetectable		 1t46A-3zdpA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP

(Salmonella
enterica) 		PF00814
(Peptidase_M22) 		4 VAL B  90
VAL B 325
ARG B  49
CYH B  10
 None
None
None
AGS  B1342 ( 4.5A)
 1.16A 1t46A-3zeuB:
undetectable		 1t46A-3zeuB:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		4 VAL G  97
CYH G 152
ARG G  58
CYH G  87
 None
 1.19A 1t46A-4adsG:
undetectable		 1t46A-4adsG:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 914
CYH A 919
ARG A1027
CYH A1045
 None
B49  A2000 (-4.2A)
None
B49  A2000 ( 4.1A)
 0.95A 1t46A-4agdA:
41.9		 1t46A-4agdA:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 914
CYH A 919
CYH A1024
CYH A1045
 None
B49  A2000 (-4.2A)
None
B49  A2000 ( 4.1A)
 0.48A 1t46A-4agdA:
41.9		 1t46A-4agdA:
49.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz4 AGMATINASE

(Burkholderia
thailandensis) 		PF00491
(Arginase) 		4 VAL A 196
VAL A 232
TYR A 149
CYH A 245
 None
 1.18A 1t46A-4dz4A:
undetectable		 1t46A-4dz4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Zea mays) 		PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH) 		4 VAL A 237
VAL A 581
TYR A 302
CYH A 640
 None
 1.29A 1t46A-4ft2A:
undetectable		 1t46A-4ft2A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i16 CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11

(Mus musculus) 		PF00619
(CARD) 		4 VAL A  90
VAL A  26
TYR A  36
CYH A  49
 None
 1.27A 1t46A-4i16A:
undetectable		 1t46A-4i16A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospora
viridis) 		PF00171
(Aldedh) 		4 VAL A 239
VAL A 236
TYR A 304
ARG A 249
 VAL  A 239 ( 0.6A)
VAL  A 236 ( 0.6A)
TYR  A 304 ( 1.3A)
ARG  A 249 ( 0.6A)
 1.21A 1t46A-4jbeA:
undetectable		 1t46A-4jbeA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jup CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11

(Homo sapiens) 		PF00619
(CARD) 		4 VAL A  90
VAL A  26
TYR A  36
CYH A  49
 None
 1.05A 1t46A-4jupA:
undetectable		 1t46A-4jupA:
17.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 553
TYR A 557
CYH A 613
ARG A 616
 None
 1.07A 1t46A-4k33A:
34.9		 1t46A-4k33A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		4 VAL A 448
VAL A 247
ARG A 170
CYH A 426
 None
 1.22A 1t46A-4m8jA:
undetectable		 1t46A-4m8jA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 VAL A 206
VAL A 217
CYH A 201
ARG A 101
 None
 1.17A 1t46A-4m9dA:
undetectable		 1t46A-4m9dA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozr ECDYSONE RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		4 VAL E 343
VAL E 371
CYH E 498
ARG E 357
 None
 1.17A 1t46A-4ozrE:
undetectable		 1t46A-4ozrE:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3k MGS-M1

(unidentified) 		PF00326
(Peptidase_S9)
PF07859
(Abhydrolase_3) 		4 VAL A 128
VAL A 109
TYR A  19
CYH A  18
 None
 1.03A 1t46A-4q3kA:
undetectable		 1t46A-4q3kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1p L-ARABINOSE
ISOMERASE

(Geobacillus
kaustophilus) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		4 VAL A  13
VAL A  36
CYH A  65
ARG A  63
 None
 1.04A 1t46A-4r1pA:
undetectable		 1t46A-4r1pA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 CYH A 694
CYH A 807
ARG A 810
CYH A 828
 None
None
None
P30  A1001 (-4.1A)
 1.04A 1t46A-4rt7A:
34.5		 1t46A-4rt7A:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 693
CYH A 694
CYH A 807
CYH A 828
 P30  A1001 (-4.1A)
None
None
P30  A1001 (-4.1A)
 0.42A 1t46A-4rt7A:
34.5		 1t46A-4rt7A:
48.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 4 VAL A 389
VAL A 400
CYH A 486
CYH A 420
 None
 1.17A 1t46A-4ru5A:
undetectable		 1t46A-4ru5A:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 693
CYH A 694
ARG A 810
CYH A 828
 P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.8A)
 1.04A 1t46A-4xufA:
39.3		 1t46A-4xufA:
60.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 693
CYH A 694
CYH A 807
CYH A 828
 P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.8A)
 0.38A 1t46A-4xufA:
39.3		 1t46A-4xufA:
60.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9a TRIOSEPHOSPHATE
ISOMERASE

(Streptomyces
coelicolor) 		PF00121
(TIM) 		4 VAL A  45
TYR A 175
CYH A 196
ARG A 257
 None
 1.19A 1t46A-4y9aA:
undetectable		 1t46A-4y9aA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z85 2-NITROBENZOATE
NITROREDUCTASE

(Pseudomonas
fluorescens) 		PF01613
(Flavin_Reduct) 		4 VAL A 129
VAL A 161
TYR A  49
CYH A  39
 None
 1.20A 1t46A-4z85A:
undetectable		 1t46A-4z85A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb 60S RIBOSOMAL
PROTEIN L10

(Dictyostelium
discoideum) 		PF00252
(Ribosomal_L16) 		4 VAL F 129
VAL F  89
CYH F  12
ARG F  10
 None
None
None
G  N3189 ( 3.9A)
 1.15A 1t46A-5anbF:
undetectable		 1t46A-5anbF:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvi INTERFERON
REGULATORY FACTOR 4

(Mus musculus) 		PF10401
(IRF-3) 		4 VAL A 316
VAL A 405
ARG A 352
CYH A 356
 None
 1.14A 1t46A-5bviA:
undetectable		 1t46A-5bviA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwj HISTONE DEMETHYLASE
JARID1C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2) 		4 VAL A 666
VAL A 674
TYR A 749
ARG A 766
 None
 1.28A 1t46A-5fwjA:
undetectable		 1t46A-5fwjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 VAL F 738
VAL F 801
TYR F 632
CYH F 509
 None
 1.26A 1t46A-5gjwF:
undetectable		 1t46A-5gjwF:
14.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 676
CYH A 677
ARG A 817
CYH A 835
 748  A1001 (-4.0A)
748  A1001 (-4.5A)
None
748  A1001 (-4.5A)
 0.28A 1t46A-5grnA:
32.9		 1t46A-5grnA:
61.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 676
CYH A 677
CYH A 814
ARG A 817
 748  A1001 (-4.0A)
748  A1001 (-4.5A)
748  A1001 (-3.4A)
None
 0.88A 1t46A-5grnA:
32.9		 1t46A-5grnA:
61.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		4 VAL A1282
VAL A1348
TYR A 877
CYH A1229
 None
 1.27A 1t46A-5gutA:
undetectable		 1t46A-5gutA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvv GLYCOSYL TRANSFERASE
FAMILY 8

(Streptococcus
pneumoniae) 		PF01501
(Glyco_transf_8) 		4 VAL A 307
VAL A 289
TYR A 389
CYH A 280
 None
 1.17A 1t46A-5gvvA:
undetectable		 1t46A-5gvvA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h11 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07393
(Sec10) 		4 VAL A 583
VAL A 590
TYR A 481
CYH A 542
 None
 1.20A 1t46A-5h11A:
undetectable		 1t46A-5h11A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		4 VAL A   8
TYR A 263
ARG A 207
CYH A 211
 None
 0.91A 1t46A-5hmqA:
undetectable		 1t46A-5hmqA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 VAL A 203
VAL A 287
CYH A 187
ARG A 212
 None
 1.24A 1t46A-5hp5A:
undetectable		 1t46A-5hp5A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 4 VAL A 231
VAL A 298
CYH A 251
CYH A 189
 None
 1.25A 1t46A-5i5jA:
2.5		 1t46A-5i5jA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 4 VAL A 441
VAL A 475
CYH A 487
ARG A  79
 None
 1.28A 1t46A-5i5jA:
2.5		 1t46A-5i5jA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ica PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12)
PF08625
(Utp13) 		4 VAL B 859
VAL A 927
TYR D 839
ARG B 812
 None
 1.20A 1t46A-5icaB:
undetectable		 1t46A-5icaB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikk HISTONE DEACETYLASE
CLR3

(Schizosaccharomyces
pombe) 		PF00850
(Hist_deacetyl)
PF09757
(Arb2) 		4 VAL A  97
CYH A 324
ARG A  83
CYH A  60
 None
None
EDO  A 710 ( 3.7A)
None
 1.27A 1t46A-5ikkA:
undetectable		 1t46A-5ikkA:
19.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 318
VAL A 342
TYR A 346
ARG A 388
 None
IPW  A 601 ( 4.4A)
IPW  A 601 (-4.5A)
None
 0.99A 1t46A-5kbrA:
21.2		 1t46A-5kbrA:
30.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mal LIPASE

(Streptomyces
rimosus) 		PF13472
(Lipase_GDSL_2) 		4 VAL A 138
VAL A 188
TYR A 215
ARG A 177
 None
 1.04A 1t46A-5malA:
undetectable		 1t46A-5malA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 4 VAL A 407
VAL A 402
TYR A 472
CYH A 453
 None
 1.14A 1t46A-5mqpA:
undetectable		 1t46A-5mqpA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 4 VAL A 303
VAL A 371
ARG A 408
CYH A 411
 None
 1.16A 1t46A-5mr7A:
undetectable		 1t46A-5mr7A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80

(Chlamydomonas
reinhardtii) 		no annotation 4 VAL A 244
TYR A 162
CYH A 161
CYH A 253
 None
 1.15A 1t46A-5n4aA:
undetectable		 1t46A-5n4aA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4c PROLYL
OLIGOPEPTIDASE

(Galerina
marginata) 		no annotation 4 VAL A 463
VAL A 380
TYR A 496
ARG A 479
 None
 1.16A 1t46A-5n4cA:
undetectable		 1t46A-5n4cA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 VAL A 153
VAL A 400
CYH A 421
ARG A 438
 None
 1.25A 1t46A-5n6uA:
undetectable		 1t46A-5n6uA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9j TRANSCRIPTION
INITIATION FACTOR
IIB,TRANSCRIPTION
INITIATION FACTOR
IIB

(Methanocaldococcus
jannaschii) 		no annotation 4 VAL A 177
VAL A  89
TYR A   4
ARG A 130
 None
 1.29A 1t46A-5o9jA:
undetectable		 1t46A-5o9jA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		4 VAL A 386
VAL A 411
CYH A 318
ARG A 380
 None
 1.22A 1t46A-5u1sA:
undetectable		 1t46A-5u1sA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3e KINESIN-LIKE PROTEIN

(Caenorhabditis
elegans) 		PF00225
(Kinesin) 		4 VAL A 211
CYH A 207
CYH A 193
ARG A 136
 None
 1.16A 1t46A-5x3eA:
undetectable		 1t46A-5x3eA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x68 KYNURENINE
3-MONOOXYGENASE

(Homo sapiens) 		no annotation 4 VAL A  19
CYH A 139
CYH A 324
ARG A 349
 FAD  A 401 (-3.5A)
MLY  A 138 ( 4.3A)
None
None
 1.07A 1t46A-5x68A:
undetectable		 1t46A-5x68A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US17

(Toxoplasma
gondii) 		PF00366
(Ribosomal_S17)
PF16205
(Ribosomal_S17_N) 		4 VAL L 109
VAL L  77
CYH L 116
ARG L  71
 C  2 305 ( 4.9A)
None
None
U  2 304 ( 3.2A)
 1.31A 1t46A-5xxuL:
undetectable		 1t46A-5xxuL:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y09 PROTEASE DO-LIKE 9

(Arabidopsis
thaliana) 		no annotation 4 VAL A 171
TYR A 257
CYH A 199
ARG A 162
 None
 1.20A 1t46A-5y09A:
undetectable		 1t46A-5y09A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio harveyi) 		no annotation 4 VAL A 131
VAL A  39
TYR A  35
ARG A 123
 None
 1.00A 1t46A-5yqwA:
undetectable		 1t46A-5yqwA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 VAL A  66
VAL A  36
TYR A 273
ARG A  90
 None
 0.99A 1t46A-6conA:
undetectable		 1t46A-6conA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cpy GRMZM2G135359
PSEUDOKINASE

(Zea mays) 		no annotation 4 VAL A 305
VAL A 213
CYH A 225
ARG A 218
 None
 1.27A 1t46A-6cpyA:
21.5		 1t46A-6cpyA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 4 VAL M 496
TYR M 402
CYH M 399
ARG M 258
 None
 1.04A 1t46A-6d6qM:
undetectable		 1t46A-6d6qM:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2

(Homo sapiens) 		no annotation 4 VAL j  59
TYR j 265
CYH j 262
CYH j 231
 None
 0.93A 1t46A-6f1yj:
undetectable		 1t46A-6f1yj:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 1,
MITOCHONDRIAL

(Mus musculus) 		no annotation 4 VAL F 124
VAL F 175
TYR F 137
CYH F 235
 None
 1.16A 1t46A-6g2jF:
undetectable		 1t46A-6g2jF:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gpl GDP-MANNOSE 4,6
DEHYDRATASE

(Homo sapiens) 		no annotation 4 VAL B 306
VAL B 285
TYR B 231
CYH B 309
 None
 1.23A 1t46A-6gplB:
undetectable		 1t46A-6gplB:
undetectable