SIMILAR PATTERNS OF AMINO ACIDS FOR 1T3R_A_017A1200_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

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	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ekq	HYDROXYETHYLTHIAZOLE KINASE (Bacillus subtilis)	PF02110 (HK)	5	LEU A 215 ALA A 119 VAL A 204 GLY A 122 ILE A 167	None	0.90A	1t3rB-1ekqA: undetectable	1t3rB-1ekqA: 16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1g5u	PROFILIN (Hevea brasiliensis)	PF00235 (Profilin)	5	LEU A1101 ALA A1024 VAL A1032 GLY A1068 ILE A1026	None	0.97A	1t3rB-1g5uA: undetectable	1t3rB-1g5uA: 23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 29 PRO A 81 ILE A 84	A79 A 800 ( 3.8A) A79 A 800 (-2.7A) A79 A 800 (-3.1A) A79 A 800 (-2.8A) A79 A 800 ( 3.9A) A79 A 800 (-3.6A)	1.43A	1t3rB-1hvcA: 14.1	1t3rB-1hvcA: 48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	LEU A 23 ASP A 25 ALA A 28 ASP A 29 PRO A 81 VAL A 82 ILE A 84	A79 A 800 ( 4.0A) A79 A 800 (-2.8A) A79 A 800 (-3.2A) A79 A 800 (-2.7A) A79 A 800 ( 3.4A) A79 A 800 (-4.5A) A79 A 800 (-3.8A)	1.35A	1t3rB-1hvcA: 14.1	1t3rB-1hvcA: 48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	LEU A 23 ASP A 25 ALA A 28 ASP A 30 VAL A 32 ILE A 50 PRO A 81 VAL A 82 ILE A 84	A79 A 800 ( 3.8A) A79 A 800 (-2.7A) A79 A 800 (-3.1A) A79 A 800 ( 4.9A) A79 A 800 ( 4.4A) A79 A 800 (-3.8A) A79 A 800 ( 3.9A) A79 A 800 (-4.5A) A79 A 800 (-3.6A)	0.69A	1t3rB-1hvcA: 14.1	1t3rB-1hvcA: 48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	8	LEU A 23 ASP A 25 ALA A 28 ASP A 30 VAL A 32 PRO A 81 VAL A 82 ILE A 84	A79 A 800 ( 4.0A) A79 A 800 (-2.8A) A79 A 800 (-3.2A) A79 A 800 ( 4.7A) A79 A 800 ( 4.3A) A79 A 800 ( 3.4A) A79 A 800 (-4.5A) A79 A 800 (-3.8A)	0.55A	1t3rB-1hvcA: 14.1	1t3rB-1hvcA: 48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	LEU A 23 ASP A 25 ALA A 28 GLY A 48 PRO A 81 VAL A 82 ILE A 84	A79 A 800 ( 4.0A) A79 A 800 (-2.8A) A79 A 800 (-3.2A) A79 A 800 (-4.1A) A79 A 800 ( 3.4A) A79 A 800 (-4.5A) A79 A 800 (-3.8A)	1.05A	1t3rB-1hvcA: 14.1	1t3rB-1hvcA: 48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	LEU A 23 ASP A 25 ALA A 28 VAL A 32 GLY A 48 VAL A 82 ILE A 84	A79 A 800 ( 3.8A) A79 A 800 (-2.7A) A79 A 800 (-3.1A) A79 A 800 ( 4.4A) A79 A 800 (-3.6A) A79 A 800 (-4.5A) A79 A 800 (-3.6A)	1.10A	1t3rB-1hvcA: 14.1	1t3rB-1hvcA: 48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	LEU A 23 ASP A 25 ALA A 28 VAL A 32 GLY A 49 ILE A 50 PRO A 81 VAL A 82 ILE A 84	A79 A 800 ( 3.8A) A79 A 800 (-2.7A) A79 A 800 (-3.1A) A79 A 800 ( 4.4A) A79 A 800 ( 3.7A) A79 A 800 (-3.8A) A79 A 800 ( 3.9A) A79 A 800 (-4.5A) A79 A 800 (-3.6A)	0.51A	1t3rB-1hvcA: 14.1	1t3rB-1hvcA: 48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	LEU A 23 ASP A 25 ALA A 28 VAL A 32 GLY A 49 ILE A 50 PRO A 81 VAL A 82 ILE A 84	A79 A 800 ( 4.0A) A79 A 800 (-2.8A) A79 A 800 (-3.2A) A79 A 800 ( 4.3A) A79 A 800 (-3.4A) A79 A 800 ( 4.0A) A79 A 800 ( 3.4A) A79 A 800 (-4.5A) A79 A 800 (-3.8A)	0.48A	1t3rB-1hvcA: 14.1	1t3rB-1hvcA: 48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 30 VAL A 32 GLY A 51 VAL A 82 ILE A 84	A79 A 800 ( 3.8A) A79 A 800 ( 4.9A) A79 A 800 ( 4.4A) None A79 A 800 (-4.5A) A79 A 800 (-3.6A)	1.02A	1t3rB-1hvcA: 14.1	1t3rB-1hvcA: 48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 30 VAL A 32 GLY A 51 VAL A 82 ILE A 84	A79 A 800 ( 4.0A) A79 A 800 ( 4.7A) A79 A 800 ( 4.3A) None A79 A 800 (-4.5A) A79 A 800 (-3.8A)	1.04A	1t3rB-1hvcA: 14.1	1t3rB-1hvcA: 48.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1iq7	OVOTRANSFERRIN (Gallus gallus)	PF00405 (Transferrin)	5	ARG A 344 LEU A 607 ALA A 391 GLY A 387 ILE A 604	None	0.94A	1t3rB-1iq7A: undetectable	1t3rB-1iq7A: 14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1nov	NODAMURA VIRUS COAT PROTEINS (Nodamura virus)	PF01829 (Peptidase_A6)	5	LEU A 113 ALA A 173 VAL A 190 VAL A 301 ILE A 299	None	0.89A	1t3rB-1novA: undetectable	1t3rB-1novA: 13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1o94	TRIMETHYLAMINE DEHYDROGENASE (Methylophilus methylotrophus)	PF00724 (Oxidored_FMN) PF07992 (Pyr_redox_2)	5	LEU A 650 GLY A 668 ILE A 666 VAL A 395 ILE A 485	ADP A1731 ( 4.6A) None None ADP A1731 (-4.7A) None	0.96A	1t3rB-1o94A: undetectable	1t3rB-1o94A: 10.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1q9p	HIV-1 PROTEASE (Homo sapiens)	PF00077 (RVP)	6	ASP A 25 ALA A 28 ASP A 30 VAL A 32 PRO A 81 ILE A 84	None	0.59A	1t3rB-1q9pA: 9.9	1t3rB-1q9pA: 91.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1shs	SMALL HEAT SHOCK PROTEIN (Methanocaldococcus jannaschii)	PF00011 (HSP20)	5	LEU A 133 ALA A 113 GLY A 34 VAL A 56 ILE A 54	None	0.91A	1t3rB-1shsA: undetectable	1t3rB-1shsA: 20.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1siv	SIV PROTEASE (Simian immunodeficiency virus)	PF00077 (RVP)	6	ARG A 8 LEU A 23 ALA A 28 ASP A 29 PRO A 81 ILE A 84	None	1.49A	1t3rB-1sivA: 18.5	1t3rB-1sivA: 49.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1siv	SIV PROTEASE (Simian immunodeficiency virus)	PF00077 (RVP)	7	ARG A 8 LEU A 23 ASP A 25 ALA A 28 ASP A 30 PRO A 81 ILE A 84	None	0.66A	1t3rB-1sivA: 18.5	1t3rB-1sivA: 49.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1siv	SIV PROTEASE (Simian immunodeficiency virus)	PF00077 (RVP)	8	ARG A 8 LEU A 23 ASP A 25 ALA A 28 GLY A 49 ILE A 50 PRO A 81 ILE A 84	None	0.53A	1t3rB-1sivA: 18.5	1t3rB-1sivA: 49.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1siv	SIV PROTEASE (Simian immunodeficiency virus)	PF00077 (RVP)	5	ASP A 25 ALA A 28 GLY A 48 PRO A 81 ILE A 84	None	0.79A	1t3rB-1sivA: 18.5	1t3rB-1sivA: 49.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1szq	2-METHYLCITRATE DEHYDRATASE (Escherichia coli)	PF03972 (MmgE_PrpD)	5	LEU A 409 ALA A 299 ILE A 354 VAL A 320 ILE A 407	None	0.92A	1t3rB-1szqA: undetectable	1t3rB-1szqA: 14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1usy	ATP PHOSPHORIBOSYLTRANSF ERASE REGULATORY SUBUNIT (Thermotoga maritima)	PF13393 (tRNA-synt_His)	5	ALA C 251 VAL C 114 ILE C 238 VAL C 109 ILE C 113	None	0.67A	1t3rB-1usyC: undetectable	1t3rB-1usyC: 16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1v5f	PYRUVATE OXIDASE (Aerococcus viridans)	PF00205 (TPP_enzyme_M) PF02775 (TPP_enzyme_C) PF02776 (TPP_enzyme_N)	5	ASP A 388 ALA A 444 ASP A 442 VAL A 466 ILE A 440	None TPP A1602 (-3.7A) MG A1603 ( 2.8A) None None	0.85A	1t3rB-1v5fA: undetectable	1t3rB-1v5fA: 10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wdt	ELONGATION FACTOR G HOMOLOG (Thermus thermophilus)	PF00009 (GTP_EFTU) PF00679 (EFG_C) PF03764 (EFG_IV) PF14492 (EFG_II)	5	ALA A 237 VAL A 213 GLY A 231 VAL A 208 ILE A 212	None	0.87A	1t3rB-1wdtA: undetectable	1t3rB-1wdtA: 8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wsv	AMINOMETHYLTRANSFERA SE (Homo sapiens)	PF01571 (GCV_T) PF08669 (GCV_T_C)	5	LEU A 152 VAL A 192 GLY A 166 VAL A 207 ILE A 205	LEU A 152 ( 0.6A) VAL A 192 ( 0.6A) GLY A 166 ( 0.0A) VAL A 207 ( 0.6A) ILE A 205 ( 0.4A)	0.73A	1t3rB-1wsvA: undetectable	1t3rB-1wsvA: 14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wu2	MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN (Pyrococcus horikoshii)	PF00994 (MoCF_biosynth) PF03453 (MoeA_N) PF03454 (MoeA_C)	5	LEU A 376 ALA A 374 VAL A 328 VAL A 391 ILE A 393	None	0.89A	1t3rB-1wu2A: undetectable	1t3rB-1wu2A: 16.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2fmb	EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE (Equine infectious anemia virus)	PF00077 (RVP)	8	LEU A 23 ASP A 25 ALA A 28 VAL A 32 GLY A 54 PRO A 86 VAL A 87 ILE A 89	None LP1 A 201 (-2.3A) LP1 A 201 (-3.5A) None LP1 A 201 (-3.6A) LP1 A 201 (-3.9A) LP1 A 201 ( 4.9A) LP1 A 201 (-4.2A)	1.13A	1t3rB-2fmbA: 15.1	1t3rB-2fmbA: 34.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2fmb	EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE (Equine infectious anemia virus)	PF00077 (RVP)	8	LEU A 23 ASP A 25 ALA A 28 VAL A 32 GLY A 55 PRO A 86 VAL A 87 ILE A 89	None LP1 A 201 (-2.3A) LP1 A 201 (-3.5A) None LP1 A 201 (-3.4A) LP1 A 201 (-3.9A) LP1 A 201 ( 4.9A) LP1 A 201 (-4.2A)	0.58A	1t3rB-2fmbA: 15.1	1t3rB-2fmbA: 34.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2hc8	CATION-TRANSPORTING ATPASE, P-TYPE (Archaeoglobus fulgidus)	PF00122 (E1-E2_ATPase)	5	ASP A 288 VAL A 290 ILE A 250 PRO A 258 VAL A 259	None	0.77A	1t3rB-2hc8A: undetectable	1t3rB-2hc8A: 25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ki7	RIBONUCLEASE P PROTEIN COMPONENT 1 (Pyrococcus furiosus)	PF01868 (UPF0086)	5	ASP A 72 VAL A 70 GLY A 110 ILE A 95 ILE A 80	None	0.93A	1t3rB-2ki7A: undetectable	1t3rB-2ki7A: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2p3e	DIAMINOPIMELATE DECARBOXYLASE (Aquifex aeolicus)	PF00278 (Orn_DAP_Arg_deC) PF02784 (Orn_Arg_deC_N)	5	ALA A 355 VAL A 371 GLY A 345 ILE A 308 ILE A 328	None	0.79A	1t3rB-2p3eA: undetectable	1t3rB-2p3eA: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2pcl	LIPOPROTEIN-RELEASIN G SYSTEM ATP-BINDING PROTEIN LOLD (Aquifex aeolicus)	PF00005 (ABC_tran)	6	ARG A 208 LEU A 210 VAL A 196 GLY A 51 VAL A 33 ILE A 35	None	1.29A	1t3rB-2pclA: undetectable	1t3rB-2pclA: 17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2qdl	CHEMOTAXIS SIGNAL TRANSDUCTION PROTEIN (Caldanaerobacter subterraneus)	PF01584 (CheW)	5	LEU A 95 VAL A 34 ILE A 14 VAL A 86 ILE A 84	None GOL A 166 ( 4.5A) None None None	0.91A	1t3rB-2qdlA: undetectable	1t3rB-2qdlA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2r9q	2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE DEAMINASE (Agrobacterium fabrum)	PF06559 (DCD)	5	LEU A 87 VAL A 229 GLY A 118 VAL A 158 ILE A 156	None	0.91A	1t3rB-2r9qA: undetectable	1t3rB-2r9qA: 14.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2rkf	PROTEASE RETROPEPSIN (Human immunodeficiency virus 1)	PF00077 (RVP)	7	ARG A 8 LEU A 23 ASP A 25 ALA A 28 ASP A 30 PRO A 81 ILE A 84	AB1 A 501 ( 4.7A) None AB1 A 501 (-2.4A) AB1 A 501 (-3.5A) AB1 A 501 (-3.8A) AB1 A 501 (-4.2A) AB1 A 501 ( 4.2A)	0.73A	1t3rB-2rkfA: 20.5	1t3rB-2rkfA: 83.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2rkf	PROTEASE RETROPEPSIN (Human immunodeficiency virus 1)	PF00077 (RVP)	8	ARG A 8 LEU A 23 ASP A 25 ALA A 28 GLY A 49 ILE A 50 PRO A 81 ILE A 84	AB1 A 501 ( 4.7A) None AB1 A 501 (-2.4A) AB1 A 501 (-3.5A) AB1 A 501 (-3.5A) AB1 A 501 (-3.8A) AB1 A 501 (-4.2A) AB1 A 501 ( 4.2A)	0.70A	1t3rB-2rkfA: 20.5	1t3rB-2rkfA: 83.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2rkf	PROTEASE RETROPEPSIN (Human immunodeficiency virus 1)	PF00077 (RVP)	5	ASP A 25 ALA A 28 GLY A 48 PRO A 81 ILE A 84	AB1 A 501 (-2.4A) AB1 A 501 (-3.5A) AB1 A 501 (-4.2A) AB1 A 501 (-4.2A) AB1 A 501 ( 4.2A)	0.76A	1t3rB-2rkfA: 20.5	1t3rB-2rkfA: 83.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2wia	FERROUS IRON TRANSPORT PROTEIN B (Klebsiella pneumoniae)	PF02421 (FeoB_N)	5	LEU A 8 VAL A 116 GLY A 155 VAL A 92 ILE A 90	None	0.91A	1t3rB-2wiaA: undetectable	1t3rB-2wiaA: 15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2y23	MYOMESIN (Homo sapiens)	PF07679 (I-set)	5	ASP A1401 GLY A1409 ILE A1410 VAL A1428 ILE A1389	None	0.81A	1t3rB-2y23A: undetectable	1t3rB-2y23A: 18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ynm	LIGHT-INDEPENDENT PROTOCHLOROPHYLLIDE REDUCTASE IRON-SULFUR ATP-BINDING PROTEIN LIGHT-INDEPENDENT PROTOCHLOROPHYLLIDE REDUCTASE SUBUNIT N (Prochlorococcus marinus)	PF00142 (Fer4_NifH) PF00148 (Oxidored_nitro)	5	LEU A 87 ALA C 71 GLY A 126 VAL A 83 ILE A 84	None None SF4 A1302 (-3.9A) None EPE A1298 (-4.9A)	0.84A	1t3rB-2ynmA: undetectable	1t3rB-2ynmA: 18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3dfi	PSEUDOAGLYCONE DEACETYLASE DBV21 (Actinoplanes teichomyceticus)	PF02585 (PIG-L)	5	LEU A 148 ALA A 12 VAL A 38 GLY A 25 ILE A 10	None	0.96A	1t3rB-3dfiA: undetectable	1t3rB-3dfiA: 15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3dkp	PROBABLE ATP-DEPENDENT RNA HELICASE DDX52 (Homo sapiens)	PF00270 (DEAD)	5	LEU A 205 ASP A 155 ILE A 160 VAL A 374 ILE A 372	None	0.96A	1t3rB-3dkpA: undetectable	1t3rB-3dkpA: 16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3i1i	HOMOSERINE O-ACETYLTRANSFERASE (Bacillus anthracis)	PF00561 (Abhydrolase_1)	5	ALA A 54 VAL A 85 GLY A 70 ILE A 355 ILE A 44	None	0.91A	1t3rB-3i1iA: undetectable	1t3rB-3i1iA: 13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3j08	COPPER-EXPORTING P-TYPE ATPASE A (Archaeoglobus fulgidus)	PF00122 (E1-E2_ATPase) PF00702 (Hydrolase)	5	ASP A 288 VAL A 290 ILE A 250 PRO A 258 VAL A 259	None	0.83A	1t3rB-3j08A: undetectable	1t3rB-3j08A: 9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3j09	COPPER-EXPORTING P-TYPE ATPASE A (Archaeoglobus fulgidus)	PF00122 (E1-E2_ATPase) PF00403 (HMA) PF00702 (Hydrolase)	5	ASP A 288 VAL A 290 ILE A 250 PRO A 258 VAL A 259	None	0.82A	1t3rB-3j09A: undetectable	1t3rB-3j09A: 8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lmm	UNCHARACTERIZED PROTEIN (Corynebacterium diphtheriae)	PF04326 (AlbA_2) PF13749 (HATPase_c_4)	5	LEU A 84 VAL A 119 GLY A 108 VAL A 134 ILE A 132	None	0.95A	1t3rB-3lmmA: undetectable	1t3rB-3lmmA: 13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3mgl	SULFATE PERMEASE FAMILY PROTEIN (Vibrio cholerae)	PF01740 (STAS)	5	LEU A 475 VAL A 532 GLY A 522 VAL A 505 ILE A 507	None	0.69A	1t3rB-3mglA: undetectable	1t3rB-3mglA: 24.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	ARG A 8 LEU A 23 ALA A 28 ASP A 29 PRO A 81 VAL A 82 ILE A 84	None	1.49A	1t3rB-3mwsA: 20.0	1t3rB-3mwsA: 76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	11	ARG A 8 LEU A 23 ASP A 25 ALA A 28 ASP A 30 VAL A 32 GLY A 49 ILE A 50 PRO A 81 VAL A 82 ILE A 84	None	0.48A	1t3rB-3mwsA: 20.0	1t3rB-3mwsA: 76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	ASP A 25 ALA A 28 VAL A 32 GLY A 48 PRO A 81 VAL A 82 ILE A 84	None	0.97A	1t3rB-3mwsA: 20.0	1t3rB-3mwsA: 76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3p4g	ANTIFREEZE PROTEIN (Marinomonas primoryensis)	no annotation	5	LEU A 162 ALA A 136 ASP A 122 VAL A 124 ILE A 143	None CA A 406 (-4.5A) CA A 404 ( 2.4A) None None	0.85A	1t3rB-3p4gA: undetectable	1t3rB-3p4gA: 13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3psg	PEPSINOGEN (Sus scrofa)	PF00026 (Asp) PF07966 (A1_Propeptide)	5	LEU A 155 ASP A 303 GLY A 34 VAL A 153 ILE A 306	None	0.95A	1t3rB-3psgA: 5.5	1t3rB-3psgA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3slz	GAG-PRO-POL POLYPROTEIN (Murine leukemia virus)	PF00077 (RVP)	5	ASP A 32 ALA A 35 VAL A 39 GLY A 56 PRO A 89	3TL A 126 (-2.4A) 3TL A 126 ( 4.0A) None 3TL A 126 (-3.4A) 3TL A 126 (-4.0A)	0.83A	1t3rB-3slzA: 11.3	1t3rB-3slzA: 27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3slz	GAG-PRO-POL POLYPROTEIN (Murine leukemia virus)	PF00077 (RVP)	5	LEU A 30 ASP A 32 ALA A 35 VAL A 39 GLY A 56	None 3TL A 126 (-2.4A) 3TL A 126 ( 4.0A) None 3TL A 126 (-3.4A)	0.54A	1t3rB-3slzA: 11.3	1t3rB-3slzA: 27.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3t3c	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	ARG A 8 LEU A 23 ASP A 25 ALA A 28 VAL A 32 GLY A 49 ILE A 50	SO4 A 101 (-3.8A) SO4 A 101 (-4.2A) 017 A 201 (-2.6A) 017 A 201 (-3.5A) None 017 A 201 (-4.0A) 017 A 201 (-3.3A)	0.87A	1t3rB-3t3cA: 18.6	1t3rB-3t3cA: 76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3t3c	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	ARG A 8 LEU A 23 ASP A 25 ALA A 28 VAL A 32 GLY A 49 PRO A 81	SO4 A 101 (-3.8A) SO4 A 101 (-4.2A) 017 A 201 (-2.6A) 017 A 201 (-3.5A) None 017 A 201 (-4.0A) None	1.04A	1t3rB-3t3cA: 18.6	1t3rB-3t3cA: 76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3t3c	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 30 VAL A 32 PRO A 81	SO4 A 101 (-4.2A) 017 A 201 (-2.6A) 017 A 201 (-3.5A) 017 A 201 (-4.2A) None None	0.81A	1t3rB-3t3cA: 18.6	1t3rB-3t3cA: 76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ttp	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ARG A 8 LEU A 23 ALA A 28 ASP A 29 PRO A 81 ILE A 84	017 A 201 ( 4.8A) None 017 A 201 (-3.4A) 017 A 201 (-3.3A) 017 A 201 (-4.1A) 017 A 201 (-4.7A)	1.48A	1t3rB-3ttpA: 19.4	1t3rB-3ttpA: 78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ttp	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	ARG A 8 LEU A 23 ASP A 25 ALA A 28 ASP A 30 GLY A 49 ILE A 50 PRO A 81 ILE A 84	017 A 201 ( 4.8A) None 017 A 201 (-2.6A) 017 A 201 (-3.4A) 017 A 201 (-4.6A) 017 A 201 (-3.0A) 017 A 201 (-3.3A) 017 A 201 (-4.1A) 017 A 201 (-4.7A)	0.66A	1t3rB-3ttpA: 19.4	1t3rB-3ttpA: 78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ttp	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	ASP A 25 ALA A 28 GLY A 48 PRO A 81 ILE A 84	017 A 201 (-2.6A) 017 A 201 (-3.4A) None 017 A 201 (-4.1A) 017 A 201 (-4.7A)	0.85A	1t3rB-3ttpA: 19.4	1t3rB-3ttpA: 78.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3u1t	DMMA HALOALKANE DEHALOGENASE (unidentified)	PF00561 (Abhydrolase_1)	5	ASP A 127 ASP A 121 GLY A 146 ILE A 142 PRO A 102	None	0.97A	1t3rB-3u1tA: undetectable	1t3rB-3u1tA: 15.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3u7s	POL POLYPROTEIN (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ARG A 8 LEU A 23 ASP A 25 ALA A 28 ASP A 30 PRO A 81	None None 017 A 202 ( 2.5A) 017 A 201 (-3.4A) 017 A 201 ( 4.0A) 017 A 202 (-4.0A)	0.65A	1t3rB-3u7sA: 19.7	1t3rB-3u7sA: 77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3u7s	POL POLYPROTEIN (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ARG A 8 LEU A 23 ASP A 25 ALA A 28 ILE A 50 PRO A 81	None None 017 A 202 ( 2.5A) 017 A 201 (-3.4A) 017 A 201 ( 3.5A) 017 A 202 (-4.0A)	0.78A	1t3rB-3u7sA: 19.7	1t3rB-3u7sA: 77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3u7s	POL POLYPROTEIN (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 GLY A 49 ILE A 50 PRO A 81	None 017 A 202 ( 2.5A) 017 A 201 (-3.4A) 017 A 202 (-2.9A) 017 A 201 ( 3.5A) 017 A 202 (-4.0A)	0.52A	1t3rB-3u7sA: 19.7	1t3rB-3u7sA: 77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3uhl	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	LEU A 23 ASP A 25 ALA A 28 PRO A 81 VAL A 82	None	0.65A	1t3rB-3uhlA: 16.1	1t3rB-3uhlA: 77.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3v70	GTPASE IMAP FAMILY MEMBER 1 (Homo sapiens)	PF04548 (AIG1)	5	LEU A 115 VAL A 81 GLY A 102 VAL A 33 ILE A 31	None	0.83A	1t3rB-3v70A: undetectable	1t3rB-3v70A: 14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ao7	ESTERASE (unidentified)	PF12146 (Hydrolase_4)	5	ALA A 125 VAL A 31 ILE A 119 PRO A 82 ILE A 79	None	0.91A	1t3rB-4ao7A: undetectable	1t3rB-4ao7A: 19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4avo	BETA-1,4-EXOCELLULAS E (Thermobifida fusca)	PF01341 (Glyco_hydro_6)	5	LEU A 178 GLY A 313 ILE A 315 VAL A 217 ILE A 219	None	0.82A	1t3rB-4avoA: undetectable	1t3rB-4avoA: 14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4f82	THIOREDOXIN REDUCTASE (Burkholderia cenocepacia)	PF08534 (Redoxin)	6	LEU A 13 ALA A 111 VAL A 83 GLY A 117 ILE A 2 VAL A 81	None	1.11A	1t3rB-4f82A: undetectable	1t3rB-4f82A: 17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4gm6	PFKB FAMILY CARBOHYDRATE KINASE (Listeria grayi)	PF00294 (PfkB)	5	ALA A 40 GLY A 33 ILE A 32 VAL A 79 ILE A 52	None GOL A 401 ( 4.1A) None None None	0.94A	1t3rB-4gm6A: undetectable	1t3rB-4gm6A: 13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4h0o	ACETATE KINASE (Entamoeba histolytica)	PF00871 (Acetate_kinase)	5	LEU A 183 GLY A 208 ILE A 195 VAL A 179 ILE A 180	None	0.88A	1t3rB-4h0oA: undetectable	1t3rB-4h0oA: 12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4i3u	ALDEHYDE DEHYDROGENASE (NAD+) (Sinorhizobium meliloti)	PF00171 (Aldedh)	5	ARG A 296 LEU A 298 VAL A 418 GLY A 432 ILE A 262	None	0.92A	1t3rB-4i3uA: undetectable	1t3rB-4i3uA: 10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4inj	LMO1638 PROTEIN (Listeria monocytogenes)	PF02016 (Peptidase_S66)	5	LEU A 162 ALA A 309 GLY A 306 ILE A 305 ILE A 321	None	0.82A	1t3rB-4injA: undetectable	1t3rB-4injA: 14.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ASP A 25 ALA A 28 VAL A 32 GLY A 48 PRO A 81 ILE A 84	RIT A 500 (-2.4A) RIT A 500 (-3.6A) None RIT A 500 (-4.8A) RIT A 500 (-3.9A) RIT A 500 (-4.3A)	0.89A	1t3rB-4njvA: 20.5	1t3rB-4njvA: 84.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	LEU A 23 ASP A 25 ALA A 28 ASP A 30 VAL A 32 GLY A 49 ILE A 50 PRO A 81 ILE A 84	None RIT A 500 (-2.4A) RIT A 500 (-3.6A) RIT A 500 (-4.8A) None RIT A 500 (-3.4A) RIT A 500 (-4.3A) RIT A 500 (-3.9A) RIT A 500 (-4.3A)	0.47A	1t3rB-4njvA: 20.5	1t3rB-4njvA: 84.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4pyr	PUTATIVE BRANCHED-CHAIN AMINO ACID ABC TRANSPORTER (Chromobacterium violaceum)	PF04348 (LppC)	5	LEU A 166 VAL A 88 GLY A 107 ILE A 337 ILE A 146	None	0.94A	1t3rB-4pyrA: undetectable	1t3rB-4pyrA: 14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4x4j	PUTATIVE OXYGENASE (Amycolatopsis orientalis)	PF01494 (FAD_binding_3)	5	LEU A 143 ASP A 125 VAL A 123 GLY A 150 VAL A 134	None	0.84A	1t3rB-4x4jA: undetectable	1t3rB-4x4jA: 13.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ydf	HTLV-1 PROTEASE (Primate T-lymphotropic virus 1)	PF00077 (RVP)	5	ARG A 10 LEU A 30 ASP A 32 VAL A 39 ILE A 100	None None 4B1 A 201 (-2.9A) None 4B1 A 201 (-4.8A)	0.84A	1t3rB-4ydfA: 13.3	1t3rB-4ydfA: 32.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ydf	HTLV-1 PROTEASE (Primate T-lymphotropic virus 1)	PF00077 (RVP)	6	LEU A 30 ASP A 32 ALA A 35 VAL A 39 GLY A 58 ILE A 100	None 4B1 A 201 (-2.9A) 4B1 A 201 (-3.6A) None 4B1 A 201 (-3.4A) 4B1 A 201 (-4.8A)	0.53A	1t3rB-4ydfA: 13.3	1t3rB-4ydfA: 32.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4z26	PUTATIVE GMC-TYPE OXIDOREDUCTASE R135 (Acanthamoeba polyphaga mimivirus)	PF00732 (GMC_oxred_N) PF05199 (GMC_oxred_C)	5	LEU A 36 VAL A 296 ILE A 267 VAL A 10 ILE A 12	None	0.66A	1t3rB-4z26A: undetectable	1t3rB-4z26A: 11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5bwi	GLYCOSIDE HYDROLASE FAMILY 79 (Burkholderia pseudomallei)	PF12891 (Glyco_hydro_44)	5	ALA A 330 ASP A 444 ILE A 324 VAL A 364 ILE A 362	None	0.85A	1t3rB-5bwiA: undetectable	1t3rB-5bwiA: 12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5elx	ATP-DEPENDENT RNA HELICASE DBP5 (Saccharomyces cerevisiae)	PF00270 (DEAD) PF00271 (Helicase_C)	5	LEU A 307 VAL A 403 GLY A 326 VAL A 435 ILE A 437	None	0.74A	1t3rB-5elxA: undetectable	1t3rB-5elxA: 18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5f15	4-AMINO-4-DEOXY-L-AR ABINOSE (L-ARA4N) TRANSFERASE (Cupriavidus metallidurans)	PF13231 (PMT_2)	5	ALA A 145 GLY A 291 ILE A 290 VAL A 349 ILE A 350	None MPG A 625 ( 3.7A) MPG A 625 ( 4.6A) None None	0.90A	1t3rB-5f15A: undetectable	1t3rB-5f15A: 11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hee	PUTATIVE UNCHARACTERIZED PROTEIN, TK2203 PROTEIN (Thermococcus kodakarensis)	PF02900 (LigB)	5	LEU A 136 VAL A 169 GLY A 232 VAL A 43 ILE A 45	None	0.80A	1t3rB-5heeA: undetectable	1t3rB-5heeA: 15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5izk	SELENOCYSTEINE-SPECI FIC ELONGATION FACTOR (Homo sapiens)	PF00009 (GTP_EFTU)	5	ALA A 315 VAL A 428 GLY A 346 VAL A 319 ILE A 317	None	0.97A	1t3rB-5izkA: undetectable	1t3rB-5izkA: 11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5jcf	MELANOMA DIFFERENTIATION ASSOCIATED PROTEIN-5 (Gallus gallus)	PF00271 (Helicase_C) PF04851 (ResIII) PF11648 (RIG-I_C-RD)	5	LEU A 708 ALA A 725 GLY A 695 ILE A 777 ILE A 761	None	0.96A	1t3rB-5jcfA: undetectable	1t3rB-5jcfA: 9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5mz9	- (-)	no annotation	6	LEU A 552 ALA A 303 GLY A 387 ILE A 385 VAL A 547 ILE A 395	None	1.13A	1t3rB-5mz9A: undetectable	1t3rB-5mz9A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5pep	PEPSIN (Sus scrofa)	PF00026 (Asp)	5	LEU A 155 ASP A 304 GLY A 34 VAL A 153 ILE A 307	None	0.92A	1t3rB-5pepA: 6.9	1t3rB-5pepA: 18.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5t2z	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	LEU A 23 ASP A 25 ALA A 28 ASP A 30 VAL A 32 PRO A 81 ILE A 84	None	0.57A	1t3rB-5t2zA: 19.6	1t3rB-5t2zA: 77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5t2z	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	8	LEU A 23 ASP A 25 ALA A 28 VAL A 32 GLY A 49 ILE A 50 PRO A 81 ILE A 84	None	0.43A	1t3rB-5t2zA: 19.6	1t3rB-5t2zA: 77.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6b3e	CYCLIN-DEPENDENT KINASE 12 (Homo sapiens)	no annotation	5	ALA A 993 ASP A 995 GLY A 923 ILE A 925 ILE A 989	None	0.93A	1t3rB-6b3eA: undetectable	1t3rB-6b3eA: 20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6bja	ACETYL-COA ACETYLTRANSFERASE A (Ascaris suum)	no annotation	5	LEU A 262 ALA A 13 ILE A 361 VAL A 279 ILE A 10	None	0.97A	1t3rB-6bjaA: undetectable	1t3rB-6bjaA: 18.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	6	ARG A 8 LEU A 23 ASP A 25 ALA A 28 ASP A 30 ILE A 84	None None NIU A 100 (-2.8A) NIU A 100 (-3.6A) None None	0.71A	1t3rB-6upjA: 17.6	1t3rB-6upjA: 48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	6	ARG A 8 LEU A 23 ASP A 25 ALA A 28 GLY A 49 ILE A 84	None None NIU A 100 (-2.8A) NIU A 100 (-3.6A) NIU A 100 ( 3.8A) None	0.84A	1t3rB-6upjA: 17.6	1t3rB-6upjA: 48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	6	ARG A 8 LEU A 23 ASP A 25 GLY A 49 ILE A 50 ILE A 84	None None NIU A 100 (-2.8A) NIU A 100 ( 3.8A) NIU A 100 (-3.9A) None	1.01A	1t3rB-6upjA: 17.6	1t3rB-6upjA: 48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	5	ASP A 25 ALA A 28 GLY A 48 PRO A 81 ILE A 84	NIU A 100 (-2.8A) NIU A 100 (-3.6A) None None None	0.92A	1t3rB-6upjA: 17.6	1t3rB-6upjA: 48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 30 PRO A 81 ILE A 84	None NIU A 100 (-2.8A) NIU A 100 (-3.6A) None None None	0.78A	1t3rB-6upjA: 17.6	1t3rB-6upjA: 48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 GLY A 49 PRO A 81 ILE A 84	None NIU A 100 (-2.8A) NIU A 100 (-3.6A) NIU A 100 ( 3.8A) None None	0.81A	1t3rB-6upjA: 17.6	1t3rB-6upjA: 48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	6	LEU A 23 ASP A 25 GLY A 49 ILE A 50 PRO A 81 ILE A 84	None NIU A 100 (-2.8A) NIU A 100 ( 3.8A) NIU A 100 (-3.9A) None None	0.94A	1t3rB-6upjA: 17.6	1t3rB-6upjA: 48.48

[["1T3R_A_017A1200_2","1ekq","Bacillus subtilis","HYDROXYETHYLTHIAZOLE KINASE","PF02110(HK)",5,"LEU A 215;ALA A 119;VAL A 204;GLY A 122;ILE A 167","None","0.90A","1t3rB-1ekqA:undetectable","1t3rB-1ekqA:16.54"],["1T3R_A_017A1200_2","1g5u","Hevea brasiliensis","PROFILIN","PF00235(Profilin)",5,"LEU A1101;ALA A1024;VAL A1032;GLY A1068;ILE A1026","None","0.97A","1t3rB-1g5uA:undetectable","1t3rB-1g5uA:23.26"],["1T3R_A_017A1200_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;PRO A  81;ILE A  84","A79 A 800 ( 3.8A);A79 A 800 (-2.7A);A79 A 800 (-3.1A);A79 A 800 (-2.8A);A79 A 800 ( 3.9A);A79 A 800 (-3.6A)","1.43A","1t3rB-1hvcA:14.1","1t3rB-1hvcA:48.28"],["1T3R_A_017A1200_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",7,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;PRO A  81;VAL A  82;ILE A  84","A79 A 800 ( 4.0A);A79 A 800 (-2.8A);A79 A 800 (-3.2A);A79 A 800 (-2.7A);A79 A 800 ( 3.4A);A79 A 800 (-4.5A);A79 A 800 (-3.8A)","1.35A","1t3rB-1hvcA:14.1","1t3rB-1hvcA:48.28"],["1T3R_A_017A1200_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"LEU A  23;ASP A  25;ALA A  28;ASP A  30;VAL A  32;ILE A  50;PRO A  81;VAL A  82;ILE A  84","A79 A 800 ( 3.8A);A79 A 800 (-2.7A);A79 A 800 (-3.1A);A79 A 800 ( 4.9A);A79 A 800 ( 4.4A);A79 A 800 (-3.8A);A79 A 800 ( 3.9A);A79 A 800 (-4.5A);A79 A 800 (-3.6A)","0.69A","1t3rB-1hvcA:14.1","1t3rB-1hvcA:48.28"],["1T3R_A_017A1200_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",8,"LEU A  23;ASP A  25;ALA A  28;ASP A  30;VAL A  32;PRO A  81;VAL A  82;ILE A  84","A79 A 800 ( 4.0A);A79 A 800 (-2.8A);A79 A 800 (-3.2A);A79 A 800 ( 4.7A);A79 A 800 ( 4.3A);A79 A 800 ( 3.4A);A79 A 800 (-4.5A);A79 A 800 (-3.8A)","0.55A","1t3rB-1hvcA:14.1","1t3rB-1hvcA:48.28"],["1T3R_A_017A1200_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",7,"LEU A  23;ASP A  25;ALA A  28;GLY A  48;PRO A  81;VAL A  82;ILE A  84","A79 A 800 ( 4.0A);A79 A 800 (-2.8A);A79 A 800 (-3.2A);A79 A 800 (-4.1A);A79 A 800 ( 3.4A);A79 A 800 (-4.5A);A79 A 800 (-3.8A)","1.05A","1t3rB-1hvcA:14.1","1t3rB-1hvcA:48.28"],["1T3R_A_017A1200_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",7,"LEU A  23;ASP A  25;ALA A  28;VAL A  32;GLY A  48;VAL A  82;ILE A  84","A79 A 800 ( 3.8A);A79 A 800 (-2.7A);A79 A 800 (-3.1A);A79 A 800 ( 4.4A);A79 A 800 (-3.6A);A79 A 800 (-4.5A);A79 A 800 (-3.6A)","1.10A","1t3rB-1hvcA:14.1","1t3rB-1hvcA:48.28"],["1T3R_A_017A1200_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"LEU A  23;ASP A  25;ALA A  28;VAL A  32;GLY A  49;ILE A  50;PRO A  81;VAL A  82;ILE A  84","A79 A 800 ( 3.8A);A79 A 800 (-2.7A);A79 A 800 (-3.1A);A79 A 800 ( 4.4A);A79 A 800 ( 3.7A);A79 A 800 (-3.8A);A79 A 800 ( 3.9A);A79 A 800 (-4.5A);A79 A 800 (-3.6A)","0.51A","1t3rB-1hvcA:14.1","1t3rB-1hvcA:48.28"],["1T3R_A_017A1200_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"LEU A  23;ASP A  25;ALA A  28;VAL A  32;GLY A  49;ILE A  50;PRO A  81;VAL A  82;ILE A  84","A79 A 800 ( 4.0A);A79 A 800 (-2.8A);A79 A 800 (-3.2A);A79 A 800 ( 4.3A);A79 A 800 (-3.4A);A79 A 800 ( 4.0A);A79 A 800 ( 3.4A);A79 A 800 (-4.5A);A79 A 800 (-3.8A)","0.48A","1t3rB-1hvcA:14.1","1t3rB-1hvcA:48.28"],["1T3R_A_017A1200_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  30;VAL A  32;GLY A  51;VAL A  82;ILE A  84","A79 A 800 ( 3.8A);A79 A 800 ( 4.9A);A79 A 800 ( 4.4A);None;A79 A 800 (-4.5A);A79 A 800 (-3.6A)","1.02A","1t3rB-1hvcA:14.1","1t3rB-1hvcA:48.28"],["1T3R_A_017A1200_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  30;VAL A  32;GLY A  51;VAL A  82;ILE A  84","A79 A 800 ( 4.0A);A79 A 800 ( 4.7A);A79 A 800 ( 4.3A);None;A79 A 800 (-4.5A);A79 A 800 (-3.8A)","1.04A","1t3rB-1hvcA:14.1","1t3rB-1hvcA:48.28"],["1T3R_A_017A1200_2","1iq7","Gallus gallus","OVOTRANSFERRIN","PF00405(Transferrin)",5,"ARG A 344;LEU A 607;ALA A 391;GLY A 387;ILE A 604","None","0.94A","1t3rB-1iq7A:undetectable","1t3rB-1iq7A:14.66"],["1T3R_A_017A1200_2","1nov","Nodamura virus","NODAMURA VIRUS COAT PROTEINS","PF01829(Peptidase_A6)",5,"LEU A 113;ALA A 173;VAL A 190;VAL A 301;ILE A 299","None","0.89A","1t3rB-1novA:undetectable","1t3rB-1novA:13.12"],["1T3R_A_017A1200_2","1o94","Methylophilus methylotrophus","TRIMETHYLAMINE DEHYDROGENASE","PF00724(Oxidored_FMN);PF07992(Pyr_redox_2)",5,"LEU A 650;GLY A 668;ILE A 666;VAL A 395;ILE A 485","ADP A1731 ( 4.6A);None;None;ADP A1731 (-4.7A);None","0.96A","1t3rB-1o94A:undetectable","1t3rB-1o94A:10.00"],["1T3R_A_017A1200_2","1q9p","Homo sapiens","HIV-1 PROTEASE","PF00077(RVP)",6,"ASP A  25;ALA A  28;ASP A  30;VAL A  32;PRO A  81;ILE A  84","None","0.59A","1t3rB-1q9pA:9.9","1t3rB-1q9pA:91.58"],["1T3R_A_017A1200_2","1shs","Methanocaldococcus jannaschii","SMALL HEAT SHOCK PROTEIN","PF00011(HSP20)",5,"LEU A 133;ALA A 113;GLY A  34;VAL A  56;ILE A  54","None","0.91A","1t3rB-1shsA:undetectable","1t3rB-1shsA:20.41"],["1T3R_A_017A1200_2","1siv","Simian immunodeficiency virus","SIV PROTEASE","PF00077(RVP)",6,"ARG A   8;LEU A  23;ALA A  28;ASP A  29;PRO A  81;ILE A  84","None","1.49A","1t3rB-1sivA:18.5","1t3rB-1sivA:49.49"],["1T3R_A_017A1200_2","1siv","Simian immunodeficiency virus","SIV PROTEASE","PF00077(RVP)",7,"ARG A   8;LEU A  23;ASP A  25;ALA A  28;ASP A  30;PRO A  81;ILE A  84","None","0.66A","1t3rB-1sivA:18.5","1t3rB-1sivA:49.49"],["1T3R_A_017A1200_2","1siv","Simian immunodeficiency virus","SIV PROTEASE","PF00077(RVP)",8,"ARG A   8;LEU A  23;ASP A  25;ALA A  28;GLY A  49;ILE A  50;PRO A  81;ILE A  84","None","0.53A","1t3rB-1sivA:18.5","1t3rB-1sivA:49.49"],["1T3R_A_017A1200_2","1siv","Simian immunodeficiency virus","SIV PROTEASE","PF00077(RVP)",5,"ASP A  25;ALA A  28;GLY A  48;PRO A  81;ILE A  84","None","0.79A","1t3rB-1sivA:18.5","1t3rB-1sivA:49.49"],["1T3R_A_017A1200_2","1szq","Escherichia coli","2-METHYLCITRATE DEHYDRATASE","PF03972(MmgE_PrpD)",5,"LEU A 409;ALA A 299;ILE A 354;VAL A 320;ILE A 407","None","0.92A","1t3rB-1szqA:undetectable","1t3rB-1szqA:14.36"],["1T3R_A_017A1200_2","1usy","Thermotoga maritima","ATP PHOSPHORIBOSYLTRANSFERASE REGULATORY SUBUNIT","PF13393(tRNA-synt_His)",5,"ALA C 251;VAL C 114;ILE C 238;VAL C 109;ILE C 113","None","0.67A","1t3rB-1usyC:undetectable","1t3rB-1usyC:16.86"],["1T3R_A_017A1200_2","1v5f","Aerococcus viridans","PYRUVATE OXIDASE","PF00205(TPP_enzyme_M);PF02775(TPP_enzyme_C);PF02776(TPP_enzyme_N)",5,"ASP A 388;ALA A 444;ASP A 442;VAL A 466;ILE A 440","None;TPP A1602 (-3.7A); MG A1603 ( 2.8A);None;None","0.85A","1t3rB-1v5fA:undetectable","1t3rB-1v5fA:10.98"],["1T3R_A_017A1200_2","1wdt","Thermus thermophilus","ELONGATION FACTOR G HOMOLOG","PF00009(GTP_EFTU);PF00679(EFG_C);PF03764(EFG_IV);PF14492(EFG_II)",5,"ALA A 237;VAL A 213;GLY A 231;VAL A 208;ILE A 212","None","0.87A","1t3rB-1wdtA:undetectable","1t3rB-1wdtA:8.86"],["1T3R_A_017A1200_2","1wsv","Homo sapiens","AMINOMETHYLTRANSFERASE","PF01571(GCV_T);PF08669(GCV_T_C)",5,"LEU A 152;VAL A 192;GLY A 166;VAL A 207;ILE A 205","LEU A 152 ( 0.6A);VAL A 192 ( 0.6A);GLY A 166 ( 0.0A);VAL A 207 ( 0.6A);ILE A 205 ( 0.4A)","0.73A","1t3rB-1wsvA:undetectable","1t3rB-1wsvA:14.13"],["1T3R_A_017A1200_2","1wu2","Pyrococcus horikoshii","MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN","PF00994(MoCF_biosynth);PF03453(MoeA_N);PF03454(MoeA_C)",5,"LEU A 376;ALA A 374;VAL A 328;VAL A 391;ILE A 393","None","0.89A","1t3rB-1wu2A:undetectable","1t3rB-1wu2A:16.85"],["1T3R_A_017A1200_2","2fmb","Equine infectious anemia virus","EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE","PF00077(RVP)",8,"LEU A  23;ASP A  25;ALA A  28;VAL A  32;GLY A  54;PRO A  86;VAL A  87;ILE A  89","None;LP1 A 201 (-2.3A);LP1 A 201 (-3.5A);None;LP1 A 201 (-3.6A);LP1 A 201 (-3.9A);LP1 A 201 ( 4.9A);LP1 A 201 (-4.2A)","1.13A","1t3rB-2fmbA:15.1","1t3rB-2fmbA:34.62"],["1T3R_A_017A1200_2","2fmb","Equine infectious anemia virus","EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE","PF00077(RVP)",8,"LEU A  23;ASP A  25;ALA A  28;VAL A  32;GLY A  55;PRO A  86;VAL A  87;ILE A  89","None;LP1 A 201 (-2.3A);LP1 A 201 (-3.5A);None;LP1 A 201 (-3.4A);LP1 A 201 (-3.9A);LP1 A 201 ( 4.9A);LP1 A 201 (-4.2A)","0.58A","1t3rB-2fmbA:15.1","1t3rB-2fmbA:34.62"],["1T3R_A_017A1200_2","2hc8","Archaeoglobus fulgidus","CATION-TRANSPORTING ATPASE, P-TYPE","PF00122(E1-E2_ATPase)",5,"ASP A 288;VAL A 290;ILE A 250;PRO A 258;VAL A 259","None","0.77A","1t3rB-2hc8A:undetectable","1t3rB-2hc8A:25.81"],["1T3R_A_017A1200_2","2ki7","Pyrococcus furiosus","RIBONUCLEASE P PROTEIN COMPONENT 1","PF01868(UPF0086)",5,"ASP A  72;VAL A  70;GLY A 110;ILE A  95;ILE A  80","None","0.93A","1t3rB-2ki7A:undetectable","1t3rB-2ki7A:21.14"],["1T3R_A_017A1200_2","2p3e","Aquifex aeolicus","DIAMINOPIMELATE DECARBOXYLASE","PF00278(Orn_DAP_Arg_deC);PF02784(Orn_Arg_deC_N)",5,"ALA A 355;VAL A 371;GLY A 345;ILE A 308;ILE A 328","None","0.79A","1t3rB-2p3eA:undetectable","1t3rB-2p3eA:12.62"],["1T3R_A_017A1200_2","2pcl","Aquifex aeolicus","LIPOPROTEIN-RELEASING SYSTEM ATP-BINDING PROTEIN LOLD","PF00005(ABC_tran)",6,"ARG A 208;LEU A 210;VAL A 196;GLY A  51;VAL A  33;ILE A  35","None","1.29A","1t3rB-2pclA:undetectable","1t3rB-2pclA:17.78"],["1T3R_A_017A1200_2","2qdl","Caldanaerobacter subterraneus","CHEMOTAXIS SIGNAL TRANSDUCTION PROTEIN","PF01584(CheW)",5,"LEU A  95;VAL A  34;ILE A  14;VAL A  86;ILE A  84","None;GOL A 166 ( 4.5A);None;None;None","0.91A","1t3rB-2qdlA:undetectable","1t3rB-2qdlA:23.08"],["1T3R_A_017A1200_2","2r9q","Agrobacterium fabrum","2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE DEAMINASE","PF06559(DCD)",5,"LEU A  87;VAL A 229;GLY A 118;VAL A 158;ILE A 156","None","0.91A","1t3rB-2r9qA:undetectable","1t3rB-2r9qA:14.71"],["1T3R_A_017A1200_2","2rkf","Human immunodeficiency virus 1","PROTEASE RETROPEPSIN","PF00077(RVP)",7,"ARG A   8;LEU A  23;ASP A  25;ALA A  28;ASP A  30;PRO A  81;ILE A  84","AB1 A 501 ( 4.7A);None;AB1 A 501 (-2.4A);AB1 A 501 (-3.5A);AB1 A 501 (-3.8A);AB1 A 501 (-4.2A);AB1 A 501 ( 4.2A)","0.73A","1t3rB-2rkfA:20.5","1t3rB-2rkfA:83.84"],["1T3R_A_017A1200_2","2rkf","Human immunodeficiency virus 1","PROTEASE RETROPEPSIN","PF00077(RVP)",8,"ARG A   8;LEU A  23;ASP A  25;ALA A  28;GLY A  49;ILE A  50;PRO A  81;ILE A  84","AB1 A 501 ( 4.7A);None;AB1 A 501 (-2.4A);AB1 A 501 (-3.5A);AB1 A 501 (-3.5A);AB1 A 501 (-3.8A);AB1 A 501 (-4.2A);AB1 A 501 ( 4.2A)","0.70A","1t3rB-2rkfA:20.5","1t3rB-2rkfA:83.84"],["1T3R_A_017A1200_2","2rkf","Human immunodeficiency virus 1","PROTEASE RETROPEPSIN","PF00077(RVP)",5,"ASP A  25;ALA A  28;GLY A  48;PRO A  81;ILE A  84","AB1 A 501 (-2.4A);AB1 A 501 (-3.5A);AB1 A 501 (-4.2A);AB1 A 501 (-4.2A);AB1 A 501 ( 4.2A)","0.76A","1t3rB-2rkfA:20.5","1t3rB-2rkfA:83.84"],["1T3R_A_017A1200_2","2wia","Klebsiella pneumoniae","FERROUS IRON TRANSPORT PROTEIN B","PF02421(FeoB_N)",5,"LEU A   8;VAL A 116;GLY A 155;VAL A  92;ILE A  90","None","0.91A","1t3rB-2wiaA:undetectable","1t3rB-2wiaA:15.47"],["1T3R_A_017A1200_2","2y23","Homo sapiens","MYOMESIN","PF07679(I-set)",5,"ASP A1401;GLY A1409;ILE A1410;VAL A1428;ILE A1389","None","0.81A","1t3rB-2y23A:undetectable","1t3rB-2y23A:18.25"],["1T3R_A_017A1200_2","2ynm","Prochlorococcus marinus","LIGHT-INDEPENDENT PROTOCHLOROPHYLLIDE REDUCTASE IRON-SULFUR ATP-BINDING PROTEIN;LIGHT-INDEPENDENT PROTOCHLOROPHYLLIDE REDUCTASE SUBUNIT N","PF00142(Fer4_NifH);PF00148(Oxidored_nitro)",5,"LEU A  87;ALA C  71;GLY A 126;VAL A  83;ILE A  84","None;None;SF4 A1302 (-3.9A);None;EPE A1298 (-4.9A)","0.84A","1t3rB-2ynmA:undetectable","1t3rB-2ynmA:18.06"],["1T3R_A_017A1200_2","3dfi","Actinoplanes teichomyceticus","PSEUDOAGLYCONE DEACETYLASE DBV21","PF02585(PIG-L)",5,"LEU A 148;ALA A  12;VAL A  38;GLY A  25;ILE A  10","None","0.96A","1t3rB-3dfiA:undetectable","1t3rB-3dfiA:15.98"],["1T3R_A_017A1200_2","3dkp","Homo sapiens","PROBABLE ATP-DEPENDENT RNA HELICASE DDX52","PF00270(DEAD)",5,"LEU A 205;ASP A 155;ILE A 160;VAL A 374;ILE A 372","None","0.96A","1t3rB-3dkpA:undetectable","1t3rB-3dkpA:16.73"],["1T3R_A_017A1200_2","3i1i","Bacillus anthracis","HOMOSERINE O-ACETYLTRANSFERASE","PF00561(Abhydrolase_1)",5,"ALA A  54;VAL A  85;GLY A  70;ILE A 355;ILE A  44","None","0.91A","1t3rB-3i1iA:undetectable","1t3rB-3i1iA:13.30"],["1T3R_A_017A1200_2","3j08","Archaeoglobus fulgidus","COPPER-EXPORTING P-TYPE ATPASE A","PF00122(E1-E2_ATPase);PF00702(Hydrolase)",5,"ASP A 288;VAL A 290;ILE A 250;PRO A 258;VAL A 259","None","0.83A","1t3rB-3j08A:undetectable","1t3rB-3j08A:9.75"],["1T3R_A_017A1200_2","3j09","Archaeoglobus fulgidus","COPPER-EXPORTING P-TYPE ATPASE A","PF00122(E1-E2_ATPase);PF00403(HMA);PF00702(Hydrolase)",5,"ASP A 288;VAL A 290;ILE A 250;PRO A 258;VAL A 259","None","0.82A","1t3rB-3j09A:undetectable","1t3rB-3j09A:8.26"],["1T3R_A_017A1200_2","3lmm","Corynebacterium diphtheriae","UNCHARACTERIZED PROTEIN","PF04326(AlbA_2);PF13749(HATPase_c_4)",5,"LEU A  84;VAL A 119;GLY A 108;VAL A 134;ILE A 132","None","0.95A","1t3rB-3lmmA:undetectable","1t3rB-3lmmA:13.25"],["1T3R_A_017A1200_2","3mgl","Vibrio cholerae","SULFATE PERMEASE FAMILY PROTEIN","PF01740(STAS)",5,"LEU A 475;VAL A 532;GLY A 522;VAL A 505;ILE A 507","None","0.69A","1t3rB-3mglA:undetectable","1t3rB-3mglA:24.43"],["1T3R_A_017A1200_2","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",7,"ARG A   8;LEU A  23;ALA A  28;ASP A  29;PRO A  81;VAL A  82;ILE A  84","None","1.49A","1t3rB-3mwsA:20.0","1t3rB-3mwsA:76.77"],["1T3R_A_017A1200_2","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",11,"ARG A   8;LEU A  23;ASP A  25;ALA A  28;ASP A  30;VAL A  32;GLY A  49;ILE A  50;PRO A  81;VAL A  82;ILE A  84","None","0.48A","1t3rB-3mwsA:20.0","1t3rB-3mwsA:76.77"],["1T3R_A_017A1200_2","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",7,"ASP A  25;ALA A  28;VAL A  32;GLY A  48;PRO A  81;VAL A  82;ILE A  84","None","0.97A","1t3rB-3mwsA:20.0","1t3rB-3mwsA:76.77"],["1T3R_A_017A1200_2","3p4g","Marinomonas primoryensis","ANTIFREEZE PROTEIN","no annotation",5,"LEU A 162;ALA A 136;ASP A 122;VAL A 124;ILE A 143","None; CA A 406 (-4.5A); CA A 404 ( 2.4A);None;None","0.85A","1t3rB-3p4gA:undetectable","1t3rB-3p4gA:13.66"],["1T3R_A_017A1200_2","3psg","Sus scrofa","PEPSINOGEN","PF00026(Asp);PF07966(A1_Propeptide)",5,"LEU A 155;ASP A 303;GLY A  34;VAL A 153;ILE A 306","None","0.95A","1t3rB-3psgA:5.5","1t3rB-3psgA:16.67"],["1T3R_A_017A1200_2","3slz","Murine leukemia virus","GAG-PRO-POL POLYPROTEIN","PF00077(RVP)",5,"ASP A  32;ALA A  35;VAL A  39;GLY A  56;PRO A  89","3TL A 126 (-2.4A);3TL A 126 ( 4.0A);None;3TL A 126 (-3.4A);3TL A 126 (-4.0A)","0.83A","1t3rB-3slzA:11.3","1t3rB-3slzA:27.41"],["1T3R_A_017A1200_2","3slz","Murine leukemia virus","GAG-PRO-POL POLYPROTEIN","PF00077(RVP)",5,"LEU A  30;ASP A  32;ALA A  35;VAL A  39;GLY A  56","None;3TL A 126 (-2.4A);3TL A 126 ( 4.0A);None;3TL A 126 (-3.4A)","0.54A","1t3rB-3slzA:11.3","1t3rB-3slzA:27.41"],["1T3R_A_017A1200_2","3t3c","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",7,"ARG A   8;LEU A  23;ASP A  25;ALA A  28;VAL A  32;GLY A  49;ILE A  50","SO4 A 101 (-3.8A);SO4 A 101 (-4.2A);017 A 201 (-2.6A);017 A 201 (-3.5A);None;017 A 201 (-4.0A);017 A 201 (-3.3A)","0.87A","1t3rB-3t3cA:18.6","1t3rB-3t3cA:76.77"],["1T3R_A_017A1200_2","3t3c","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",7,"ARG A   8;LEU A  23;ASP A  25;ALA A  28;VAL A  32;GLY A  49;PRO A  81","SO4 A 101 (-3.8A);SO4 A 101 (-4.2A);017 A 201 (-2.6A);017 A 201 (-3.5A);None;017 A 201 (-4.0A);None","1.04A","1t3rB-3t3cA:18.6","1t3rB-3t3cA:76.77"],["1T3R_A_017A1200_2","3t3c","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  30;VAL A  32;PRO A  81","SO4 A 101 (-4.2A);017 A 201 (-2.6A);017 A 201 (-3.5A);017 A 201 (-4.2A);None;None","0.81A","1t3rB-3t3cA:18.6","1t3rB-3t3cA:76.77"],["1T3R_A_017A1200_2","3ttp","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"ARG A   8;LEU A  23;ALA A  28;ASP A  29;PRO A  81;ILE A  84","017 A 201 ( 4.8A);None;017 A 201 (-3.4A);017 A 201 (-3.3A);017 A 201 (-4.1A);017 A 201 (-4.7A)","1.48A","1t3rB-3ttpA:19.4","1t3rB-3ttpA:78.79"],["1T3R_A_017A1200_2","3ttp","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"ARG A   8;LEU A  23;ASP A  25;ALA A  28;ASP A  30;GLY A  49;ILE A  50;PRO A  81;ILE A  84","017 A 201 ( 4.8A);None;017 A 201 (-2.6A);017 A 201 (-3.4A);017 A 201 (-4.6A);017 A 201 (-3.0A);017 A 201 (-3.3A);017 A 201 (-4.1A);017 A 201 (-4.7A)","0.66A","1t3rB-3ttpA:19.4","1t3rB-3ttpA:78.79"],["1T3R_A_017A1200_2","3ttp","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",5,"ASP A  25;ALA A  28;GLY A  48;PRO A  81;ILE A  84","017 A 201 (-2.6A);017 A 201 (-3.4A);None;017 A 201 (-4.1A);017 A 201 (-4.7A)","0.85A","1t3rB-3ttpA:19.4","1t3rB-3ttpA:78.79"],["1T3R_A_017A1200_2","3u1t","unidentified","DMMA HALOALKANE DEHALOGENASE","PF00561(Abhydrolase_1)",5,"ASP A 127;ASP A 121;GLY A 146;ILE A 142;PRO A 102","None","0.97A","1t3rB-3u1tA:undetectable","1t3rB-3u1tA:15.86"],["1T3R_A_017A1200_2","3u7s","Human immunodeficiency virus 1","POL POLYPROTEIN","PF00077(RVP)",6,"ARG A   8;LEU A  23;ASP A  25;ALA A  28;ASP A  30;PRO A  81","None;None;017 A 202 ( 2.5A);017 A 201 (-3.4A);017 A 201 ( 4.0A);017 A 202 (-4.0A)","0.65A","1t3rB-3u7sA:19.7","1t3rB-3u7sA:77.78"],["1T3R_A_017A1200_2","3u7s","Human immunodeficiency virus 1","POL POLYPROTEIN","PF00077(RVP)",6,"ARG A   8;LEU A  23;ASP A  25;ALA A  28;ILE A  50;PRO A  81","None;None;017 A 202 ( 2.5A);017 A 201 (-3.4A);017 A 201 ( 3.5A);017 A 202 (-4.0A)","0.78A","1t3rB-3u7sA:19.7","1t3rB-3u7sA:77.78"],["1T3R_A_017A1200_2","3u7s","Human immunodeficiency virus 1","POL POLYPROTEIN","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;GLY A  49;ILE A  50;PRO A  81","None;017 A 202 ( 2.5A);017 A 201 (-3.4A);017 A 202 (-2.9A);017 A 201 ( 3.5A);017 A 202 (-4.0A)","0.52A","1t3rB-3u7sA:19.7","1t3rB-3u7sA:77.78"],["1T3R_A_017A1200_2","3uhl","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",5,"LEU A  23;ASP A  25;ALA A  28;PRO A  81;VAL A  82","None","0.65A","1t3rB-3uhlA:16.1","1t3rB-3uhlA:77.78"],["1T3R_A_017A1200_2","3v70","Homo sapiens","GTPASE IMAP FAMILY MEMBER 1","PF04548(AIG1)",5,"LEU A 115;VAL A  81;GLY A 102;VAL A  33;ILE A  31","None","0.83A","1t3rB-3v70A:undetectable","1t3rB-3v70A:14.92"],["1T3R_A_017A1200_2","4ao7","unidentified","ESTERASE","PF12146(Hydrolase_4)",5,"ALA A 125;VAL A  31;ILE A 119;PRO A  82;ILE A  79","None","0.91A","1t3rB-4ao7A:undetectable","1t3rB-4ao7A:19.70"],["1T3R_A_017A1200_2","4avo","Thermobifida fusca","BETA-1,4-EXOCELLULASE","PF01341(Glyco_hydro_6)",5,"LEU A 178;GLY A 313;ILE A 315;VAL A 217;ILE A 219","None","0.82A","1t3rB-4avoA:undetectable","1t3rB-4avoA:14.40"],["1T3R_A_017A1200_2","4f82","Burkholderia cenocepacia","THIOREDOXIN REDUCTASE","PF08534(Redoxin)",6,"LEU A  13;ALA A 111;VAL A  83;GLY A 117;ILE A   2;VAL A  81","None","1.11A","1t3rB-4f82A:undetectable","1t3rB-4f82A:17.32"],["1T3R_A_017A1200_2","4gm6","Listeria grayi","PFKB FAMILY CARBOHYDRATE KINASE","PF00294(PfkB)",5,"ALA A  40;GLY A  33;ILE A  32;VAL A  79;ILE A  52","None;GOL A 401 ( 4.1A);None;None;None","0.94A","1t3rB-4gm6A:undetectable","1t3rB-4gm6A:13.75"],["1T3R_A_017A1200_2","4h0o","Entamoeba histolytica","ACETATE KINASE","PF00871(Acetate_kinase)",5,"LEU A 183;GLY A 208;ILE A 195;VAL A 179;ILE A 180","None","0.88A","1t3rB-4h0oA:undetectable","1t3rB-4h0oA:12.13"],["1T3R_A_017A1200_2","4i3u","Sinorhizobium meliloti","ALDEHYDE DEHYDROGENASE (NAD+)","PF00171(Aldedh)",5,"ARG A 296;LEU A 298;VAL A 418;GLY A 432;ILE A 262","None","0.92A","1t3rB-4i3uA:undetectable","1t3rB-4i3uA:10.41"],["1T3R_A_017A1200_2","4inj","Listeria monocytogenes","LMO1638 PROTEIN","PF02016(Peptidase_S66)",5,"LEU A 162;ALA A 309;GLY A 306;ILE A 305;ILE A 321","None","0.82A","1t3rB-4injA:undetectable","1t3rB-4injA:14.47"],["1T3R_A_017A1200_2","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",6,"ASP A  25;ALA A  28;VAL A  32;GLY A  48;PRO A  81;ILE A  84","RIT A 500 (-2.4A);RIT A 500 (-3.6A);None;RIT A 500 (-4.8A);RIT A 500 (-3.9A);RIT A 500 (-4.3A)","0.89A","1t3rB-4njvA:20.5","1t3rB-4njvA:84.85"],["1T3R_A_017A1200_2","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",9,"LEU A  23;ASP A  25;ALA A  28;ASP A  30;VAL A  32;GLY A  49;ILE A  50;PRO A  81;ILE A  84","None;RIT A 500 (-2.4A);RIT A 500 (-3.6A);RIT A 500 (-4.8A);None;RIT A 500 (-3.4A);RIT A 500 (-4.3A);RIT A 500 (-3.9A);RIT A 500 (-4.3A)","0.47A","1t3rB-4njvA:20.5","1t3rB-4njvA:84.85"],["1T3R_A_017A1200_2","4pyr","Chromobacterium violaceum","PUTATIVE BRANCHED-CHAIN AMINO ACID ABC TRANSPORTER","PF04348(LppC)",5,"LEU A 166;VAL A  88;GLY A 107;ILE A 337;ILE A 146","None","0.94A","1t3rB-4pyrA:undetectable","1t3rB-4pyrA:14.24"],["1T3R_A_017A1200_2","4x4j","Amycolatopsis orientalis","PUTATIVE OXYGENASE","PF01494(FAD_binding_3)",5,"LEU A 143;ASP A 125;VAL A 123;GLY A 150;VAL A 134","None","0.84A","1t3rB-4x4jA:undetectable","1t3rB-4x4jA:13.14"],["1T3R_A_017A1200_2","4ydf","Primate T-lymphotropic virus 1","HTLV-1 PROTEASE","PF00077(RVP)",5,"ARG A  10;LEU A  30;ASP A  32;VAL A  39;ILE A 100","None;None;4B1 A 201 (-2.9A);None;4B1 A 201 (-4.8A)","0.84A","1t3rB-4ydfA:13.3","1t3rB-4ydfA:32.76"],["1T3R_A_017A1200_2","4ydf","Primate T-lymphotropic virus 1","HTLV-1 PROTEASE","PF00077(RVP)",6,"LEU A  30;ASP A  32;ALA A  35;VAL A  39;GLY A  58;ILE A 100","None;4B1 A 201 (-2.9A);4B1 A 201 (-3.6A);None;4B1 A 201 (-3.4A);4B1 A 201 (-4.8A)","0.53A","1t3rB-4ydfA:13.3","1t3rB-4ydfA:32.76"],["1T3R_A_017A1200_2","4z26","Acanthamoeba polyphaga mimivirus","PUTATIVE GMC-TYPE OXIDOREDUCTASE R135","PF00732(GMC_oxred_N);PF05199(GMC_oxred_C)",5,"LEU A  36;VAL A 296;ILE A 267;VAL A  10;ILE A  12","None","0.66A","1t3rB-4z26A:undetectable","1t3rB-4z26A:11.03"],["1T3R_A_017A1200_2","5bwi","Burkholderia pseudomallei","GLYCOSIDE HYDROLASE FAMILY 79","PF12891(Glyco_hydro_44)",5,"ALA A 330;ASP A 444;ILE A 324;VAL A 364;ILE A 362","None","0.85A","1t3rB-5bwiA:undetectable","1t3rB-5bwiA:12.58"],["1T3R_A_017A1200_2","5elx","Saccharomyces cerevisiae","ATP-DEPENDENT RNA HELICASE DBP5","PF00270(DEAD);PF00271(Helicase_C)",5,"LEU A 307;VAL A 403;GLY A 326;VAL A 435;ILE A 437","None","0.74A","1t3rB-5elxA:undetectable","1t3rB-5elxA:18.28"],["1T3R_A_017A1200_2","5f15","Cupriavidus metallidurans","4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N) TRANSFERASE","PF13231(PMT_2)",5,"ALA A 145;GLY A 291;ILE A 290;VAL A 349;ILE A 350","None;MPG A 625 ( 3.7A);MPG A 625 ( 4.6A);None;None","0.90A","1t3rB-5f15A:undetectable","1t3rB-5f15A:11.41"],["1T3R_A_017A1200_2","5hee","Thermococcus kodakarensis","PUTATIVE UNCHARACTERIZED PROTEIN, TK2203 PROTEIN","PF02900(LigB)",5,"LEU A 136;VAL A 169;GLY A 232;VAL A  43;ILE A  45","None","0.80A","1t3rB-5heeA:undetectable","1t3rB-5heeA:15.48"],["1T3R_A_017A1200_2","5izk","Homo sapiens","SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR","PF00009(GTP_EFTU)",5,"ALA A 315;VAL A 428;GLY A 346;VAL A 319;ILE A 317","None","0.97A","1t3rB-5izkA:undetectable","1t3rB-5izkA:11.42"],["1T3R_A_017A1200_2","5jcf","Gallus gallus","MELANOMA DIFFERENTIATION ASSOCIATED PROTEIN-5","PF00271(Helicase_C);PF04851(ResIII);PF11648(RIG-I_C-RD)",5,"LEU A 708;ALA A 725;GLY A 695;ILE A 777;ILE A 761","None","0.96A","1t3rB-5jcfA:undetectable","1t3rB-5jcfA:9.42"],["1T3R_A_017A1200_2","5mz9","-","-","no annotation",6,"LEU A 552;ALA A 303;GLY A 387;ILE A 385;VAL A 547;ILE A 395","None","1.13A","1t3rB-5mz9A:undetectable","1t3rB-5mz9A:undetectable"],["1T3R_A_017A1200_2","5pep","Sus scrofa","PEPSIN","PF00026(Asp)",5,"LEU A 155;ASP A 304;GLY A  34;VAL A 153;ILE A 307","None","0.92A","1t3rB-5pepA:6.9","1t3rB-5pepA:18.44"],["1T3R_A_017A1200_2","5t2z","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",7,"LEU A  23;ASP A  25;ALA A  28;ASP A  30;VAL A  32;PRO A  81;ILE A  84","None","0.57A","1t3rB-5t2zA:19.6","1t3rB-5t2zA:77.78"],["1T3R_A_017A1200_2","5t2z","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",8,"LEU A  23;ASP A  25;ALA A  28;VAL A  32;GLY A  49;ILE A  50;PRO A  81;ILE A  84","None","0.43A","1t3rB-5t2zA:19.6","1t3rB-5t2zA:77.78"],["1T3R_A_017A1200_2","6b3e","Homo sapiens","CYCLIN-DEPENDENT KINASE 12","no annotation",5,"ALA A 993;ASP A 995;GLY A 923;ILE A 925;ILE A 989","None","0.93A","1t3rB-6b3eA:undetectable","1t3rB-6b3eA:20.20"],["1T3R_A_017A1200_2","6bja","Ascaris suum","ACETYL-COA ACETYLTRANSFERASE A","no annotation",5,"LEU A 262;ALA A  13;ILE A 361;VAL A 279;ILE A  10","None","0.97A","1t3rB-6bjaA:undetectable","1t3rB-6bjaA:18.56"],["1T3R_A_017A1200_2","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",6,"ARG A   8;LEU A  23;ASP A  25;ALA A  28;ASP A  30;ILE A  84","None;None;NIU A 100 (-2.8A);NIU A 100 (-3.6A);None;None","0.71A","1t3rB-6upjA:17.6","1t3rB-6upjA:48.48"],["1T3R_A_017A1200_2","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",6,"ARG A   8;LEU A  23;ASP A  25;ALA A  28;GLY A  49;ILE A  84","None;None;NIU A 100 (-2.8A);NIU A 100 (-3.6A);NIU A 100 ( 3.8A);None","0.84A","1t3rB-6upjA:17.6","1t3rB-6upjA:48.48"],["1T3R_A_017A1200_2","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",6,"ARG A   8;LEU A  23;ASP A  25;GLY A  49;ILE A  50;ILE A  84","None;None;NIU A 100 (-2.8A);NIU A 100 ( 3.8A);NIU A 100 (-3.9A);None","1.01A","1t3rB-6upjA:17.6","1t3rB-6upjA:48.48"],["1T3R_A_017A1200_2","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",5,"ASP A  25;ALA A  28;GLY A  48;PRO A  81;ILE A  84","NIU A 100 (-2.8A);NIU A 100 (-3.6A);None;None;None","0.92A","1t3rB-6upjA:17.6","1t3rB-6upjA:48.48"],["1T3R_A_017A1200_2","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  30;PRO A  81;ILE A  84","None;NIU A 100 (-2.8A);NIU A 100 (-3.6A);None;None;None","0.78A","1t3rB-6upjA:17.6","1t3rB-6upjA:48.48"],["1T3R_A_017A1200_2","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;GLY A  49;PRO A  81;ILE A  84","None;NIU A 100 (-2.8A);NIU A 100 (-3.6A);NIU A 100 ( 3.8A);None;None","0.81A","1t3rB-6upjA:17.6","1t3rB-6upjA:48.48"],["1T3R_A_017A1200_2","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;GLY A  49;ILE A  50;PRO A  81;ILE A  84","None;NIU A 100 (-2.8A);NIU A 100 ( 3.8A);NIU A 100 (-3.9A);None;None","0.94A","1t3rB-6upjA:17.6","1t3rB-6upjA:48.48"]]