SIMILAR PATTERNS OF AMINO ACIDS FOR 1T03_P_TFOP822
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ffv | CUTL, MOLYBDOPROTEINOF CARBON MONOXIDEDEHYDROGENASECUTM, FLAVOPROTEINOF CARBON MONOXIDEDEHYDROGENASECUTS, IRON-SULFURPROTEIN OF CARBONMONOXIDEDEHYDROGENASE (Hydrogenophagapseudoflava) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 4 | MET B 49ASP B 50LYS C 1HIS A 27 | None | 0.95A | 1t03A-1ffvB:undetectable | 1t03A-1ffvB:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1im5 | 180AA LONGHYPOTHETICALPYRAZINAMIDASE/NICOTINAMIDASE (Pyrococcushorikoshii) |
PF00857(Isochorismatase) | 4 | ASP A 52TYR A 132ASP A 10HIS A 58 | ZN A 400 (-2.5A)NoneNoneNone | 1.26A | 1t03A-1im5A:undetectable | 1t03A-1im5A:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1khw | RNA-DIRECTED RNAPOLYMERASE (Rabbithemorrhagicdisease virus) |
PF00680(RdRP_1) | 4 | ASP A 250TYR A 352ASP A 354ASP A 355 | MN A 602 ( 2.6A)None MN A 601 ( 2.3A) MN A 601 (-4.0A) | 0.90A | 1t03A-1khwA:4.9 | 1t03A-1khwA:22.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mu2 | HIV-2 RT (Humanimmunodeficiencyvirus 2) |
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 4 | ASP A 110TYR A 183ASP A 185ASP A 186 | None | 0.87A | 1t03A-1mu2A:30.7 | 1t03A-1mu2A:60.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mu2 | HIV-2 RT (Humanimmunodeficiencyvirus 2) |
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 4 | ASP A 110TYR A 183ASP A 186LYS A 220 | None | 0.97A | 1t03A-1mu2A:30.7 | 1t03A-1mu2A:60.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mu2 | HIV-2 RT (Humanimmunodeficiencyvirus 2) |
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 4 | ASP A 110TYR A 183MET A 184ASP A 185 | None | 1.24A | 1t03A-1mu2A:30.7 | 1t03A-1mu2A:60.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5t | TRYPTOPHANYL-TRNASYNTHETASE (Homo sapiens) |
PF00579(tRNA-synt_1b) | 4 | ASP A 198MET A 195ASP A 197ASP A 237 | None | 1.48A | 1t03A-1o5tA:undetectable | 1t03A-1o5tA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1og6 | HYPOTHETICALOXIDOREDUCTASE YDHF (Escherichiacoli) |
PF00248(Aldo_ket_red) | 4 | TYR A 21MET A 19ASP A 50HIS A 128 | NoneNoneNAP A1298 (-3.6A)NAP A1298 (-4.6A) | 1.22A | 1t03A-1og6A:undetectable | 1t03A-1og6A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p32 | MITOCHONDRIAL MATRIXPROTEIN, SF2P32 (Homo sapiens) |
PF02330(MAM33) | 4 | TYR A 236MET A 240ASP A 241ASP A 237 | None | 1.21A | 1t03A-1p32A:undetectable | 1t03A-1p32A:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r6u | TRYPTOPHANYL-TRNASYNTHETASE (Homo sapiens) |
PF00579(tRNA-synt_1b) | 4 | ASP A 198MET A 195ASP A 197ASP A 237 | None | 1.45A | 1t03A-1r6uA:undetectable | 1t03A-1r6uA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rqj | GERANYLTRANSTRANSFERASE (Escherichiacoli) |
PF00348(polyprenyl_synt) | 4 | MET A 110ASP A 111ASP A 106LYS A 258 | None MG A 909 (-2.4A)NoneRIS A 901 (-2.7A) | 1.27A | 1t03A-1rqjA:undetectable | 1t03A-1rqjA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1spi | FRUCTOSE1,6-BISPHOSPHATASE (Spinaciaoleracea) |
PF00316(FBPase) | 4 | TYR A 252MET A 253ASP A 254ASP A 255 | None | 1.26A | 1t03A-1spiA:undetectable | 1t03A-1spiA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w07 | ACYL-COA OXIDASE (Arabidopsisthaliana) |
PF01756(ACOX)PF02770(Acyl-CoA_dh_M)PF14749(Acyl-CoA_ox_N) | 4 | ASP A 224TYR A 234MET A 237ASP A 238 | NoneFAD A1660 ( 4.1A)NoneNone | 1.32A | 1t03A-1w07A:undetectable | 1t03A-1w07A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y3n | ALGQ1 (Sphingomonassp. A1) |
PF01547(SBP_bac_1) | 4 | TYR A 393ASP A 392ASP A 132HIS A 110 | None | 1.21A | 1t03A-1y3nA:undetectable | 1t03A-1y3nA:25.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bhm | TYPE IV SECRETIONSYSTEM PROTEIN VIRB8 (Brucella suis) |
PF04335(VirB8) | 4 | TYR A 98MET A 102ASP A 103ASP A 99 | None | 1.11A | 1t03A-2bhmA:undetectable | 1t03A-2bhmA:16.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ddh | ACYL-COA OXIDASE (Rattusnorvegicus) |
PF01756(ACOX)PF02770(Acyl-CoA_dh_M)PF14749(Acyl-CoA_ox_N) | 4 | ASP A 225TYR A 232MET A 235ASP A 236 | NoneFAD A 699 ( 3.8A)NoneNone | 1.31A | 1t03A-2ddhA:undetectable | 1t03A-2ddhA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fon | PEROXISOMAL ACYL-COAOXIDASE 1A (Solanumlycopersicum) |
PF01756(ACOX)PF02770(Acyl-CoA_dh_M)PF14749(Acyl-CoA_ox_N) | 4 | ASP A 224TYR A 234MET A 237ASP A 238 | NoneFAD A1000 ( 4.2A)NoneNone | 1.26A | 1t03A-2fonA:undetectable | 1t03A-2fonA:22.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hnz | REVERSETRANSCRIPTASE/RIBONUCLEASE H (Humanimmunodeficiencyvirus 1) |
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 4 | ASP A 110TYR A 183MET A 184ASP A 185 | None | 0.74A | 1t03A-2hnzA:34.5 | 1t03A-2hnzA:97.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijd | PICORNAIN 3C,RNA-DIRECTED RNAPOLYMERASE (Enterovirus C) |
PF00548(Peptidase_C3)PF00680(RdRP_1) | 4 | TYR 1 509ASP 1 511ASP 1 512LYS 1 542 | NoneNoneNoneSO4 1 648 (-3.2A) | 0.98A | 1t03A-2ijd1:3.6 | 1t03A-2ijd1:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2odf | HYPOTHETICAL PROTEINATU2144 (Agrobacteriumfabrum) |
PF05013(FGase) | 4 | TYR A 87MET A 99ASP A 88HIS A 154 | None | 1.30A | 1t03A-2odfA:undetectable | 1t03A-2odfA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qps | ALPHA-AMYLASE TYPE AISOZYME (Hordeum vulgare) |
PF00128(Alpha-amylase)PF07821(Alpha-amyl_C2) | 4 | ASP A 149ASP A 143ASP A 139HIS A 152 | CA A 502 ( 3.3A) CA A 502 (-2.8A) CA A 500 (-2.3A)None | 1.49A | 1t03A-2qpsA:undetectable | 1t03A-2qpsA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vk9 | ALPHA-TOXIN (Clostridiumnovyi) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 4 | ASP A 496MET A 447ASP A 448HIS A 489 | None | 1.30A | 1t03A-2vk9A:undetectable | 1t03A-2vk9A:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vx8 | NUCLEOPORIN-LIKEPROTEIN RIP,VESICLE-ASSOCIATEDMEMBRANE PROTEIN 7 (Homo sapiens;Mus musculus) |
PF13774(Longin) | 4 | ASP A 112TYR A 93ASP A 111ASP A 110 | None | 1.44A | 1t03A-2vx8A:undetectable | 1t03A-2vx8A:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2we9 | MOBA-RELATED PROTEIN (Mycobacteriumtuberculosis) |
PF12804(NTP_transf_3) | 4 | ASP A 181ASP A 183ASP A 105HIS A 137 | NoneNoneGOL A1196 (-3.4A)None | 1.41A | 1t03A-2we9A:undetectable | 1t03A-2we9A:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xh1 | KYNURENINE/ALPHA-AMINOADIPATEAMINOTRANSFERASE,MITOCHONDRIAL (Homo sapiens) |
PF00155(Aminotran_1_2) | 4 | TYR A 233ASP A 230ASP A 231HIS A 95 | PLP A1427 (-4.9A)PLP A1427 (-2.8A)NoneNone | 1.18A | 1t03A-2xh1A:2.7 | 1t03A-2xh1A:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zxq | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Bifidobacteriumlongum) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 4 | TYR A 688ASP A 774ASP A 687HIS A1304 | None | 1.16A | 1t03A-2zxqA:undetectable | 1t03A-2zxqA:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2b | SERINEPALMITOYLTRANSFERASE (Sphingobacteriummultivorum) |
PF00155(Aminotran_1_2) | 4 | ASP A 181ASP A 210ASP A 137HIS A 157 | PLP A 400 (-3.8A)PLP A 400 (-2.6A)NoneNone | 1.35A | 1t03A-3a2bA:3.0 | 1t03A-3a2bA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ay3 | NAD-DEPENDENTEPIMERASE/DEHYDRATASE (Chromohalobactersalexigens) |
PF01370(Epimerase) | 4 | ASP A 227MET A 185ASP A 182ASP A 183 | None | 1.47A | 1t03A-3ay3A:undetectable | 1t03A-3ay3A:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c5r | BRCA1-ASSOCIATEDRING DOMAIN PROTEIN1 (Homo sapiens) |
PF12796(Ank_2) | 4 | ASP A 500TYR A 492ASP A 495HIS A 471 | None | 1.19A | 1t03A-3c5rA:undetectable | 1t03A-3c5rA:13.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dou | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE J (Thermoplasmavolcanium) |
PF01728(FtsJ) | 4 | TYR A 128MET A 157ASP A 160LYS A 167 | None | 1.46A | 1t03A-3douA:undetectable | 1t03A-3douA:14.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3etv | PROTEIN TRANSPORTPROTEIN TIP20,PROTEIN TRANSPORTPROTEIN DSL1 CHIMERA (Saccharomycescerevisiae) |
PF11988(Dsl1_N) | 4 | TYR A 168MET A 172ASP A 173ASP A 169 | None | 0.96A | 1t03A-3etvA:undetectable | 1t03A-3etvA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fbg | PUTATIVE ARGINATELYASE (Staphylococcushaemolyticus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | ASP A 279ASP A 278LYS A 282HIS A 283 | None | 1.48A | 1t03A-3fbgA:undetectable | 1t03A-3fbgA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i05 | TRYPTOPHANYL-TRNASYNTHETASE (Trypanosomabrucei) |
PF00579(tRNA-synt_1b) | 4 | ASP A 115MET A 112ASP A 114ASP A 154 | None | 1.47A | 1t03A-3i05A:undetectable | 1t03A-3i05A:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3io1 | AMINOBENZOYL-GLUTAMATE UTILIZATIONPROTEIN (Klebsiellapneumoniae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | ASP A 151ASP A 118ASP A 116HIS A 208 | NA A 501 (-2.0A) NA A 501 ( 4.9A) NA A 501 (-3.0A)None | 1.28A | 1t03A-3io1A:3.6 | 1t03A-3io1A:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k93 | PHAGE RELATEDEXONUCLEASE (Histophilussomni) |
no annotation | 4 | ASP A 99TYR A 136ASP A 110LYS A 84 | NA A 223 (-2.8A)PEG A 228 (-4.5A) NA A 223 (-2.9A)None | 1.43A | 1t03A-3k93A:undetectable | 1t03A-3k93A:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kyd | SUMO-ACTIVATINGENZYME SUBUNIT 1 (Homo sapiens) |
PF00899(ThiF) | 4 | ASP A 239TYR A 161MET A 334ASP A 332 | EDO A 347 (-3.9A)NoneNoneNone | 1.48A | 1t03A-3kydA:undetectable | 1t03A-3kydA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kyd | SUMO-ACTIVATINGENZYME SUBUNIT 1 (Homo sapiens) |
PF00899(ThiF) | 4 | ASP A 239TYR A 294MET A 334ASP A 332 | EDO A 347 (-3.9A)NoneNoneNone | 1.32A | 1t03A-3kydA:undetectable | 1t03A-3kydA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mmp | RNA-DIRECTED RNAPOLYMERASE BETACHAIN (Escherichiavirus Qbeta) |
no annotation | 4 | TYR G 357ASP G 359ASP G 360HIS G 400 | None | 1.43A | 1t03A-3mmpG:2.1 | 1t03A-3mmpG:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nf2 | PUTATIVE POLYPRENYLSYNTHETASE (Streptomycescoelicolor) |
PF00348(polyprenyl_synt) | 4 | ASP A 134MET A 131ASP A 132ASP A 129 | NoneNoneSO4 A 3 (-4.2A)None | 1.47A | 1t03A-3nf2A:undetectable | 1t03A-3nf2A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o6n | APL1 (Anophelesgambiae) |
PF00560(LRR_1)PF13855(LRR_8) | 4 | ASP A 503TYR A 457ASP A 502HIS A 481 | NoneNAG A1004 (-3.9A)NAG A1004 (-3.8A)None | 1.46A | 1t03A-3o6nA:undetectable | 1t03A-3o6nA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qd2 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Mus musculus) |
PF00069(Pkinase) | 4 | MET B 945ASP B 946ASP B 947HIS B 914 | None | 1.39A | 1t03A-3qd2B:undetectable | 1t03A-3qd2B:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tmc | UNCHARACTERIZEDPROTEIN (Bdellovibriobacteriovorus) |
PF13487(HD_5) | 4 | MET A 267ASP A 268LYS A 145HIS A 149 | NoneDMS A 312 (-4.0A)NoneDMS A 312 (-4.0A) | 1.00A | 1t03A-3tmcA:undetectable | 1t03A-3tmcA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wc3 | ENDO-1,4-BETA-GLUCANASE (Eisenia fetida) |
PF00759(Glyco_hydro_9) | 4 | TYR A 73ASP A 143ASP A 77HIS A 378 | NoneNoneNoneGOL A 505 (-4.3A) | 1.49A | 1t03A-3wc3A:undetectable | 1t03A-3wc3A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zsc | PECTATETRISACCHARIDE-LYASE (Thermotogamaritima) |
PF00544(Pec_lyase_C) | 4 | ASP A 139ASP A 115ASP A 117HIS A 161 | AQA A1338 (-3.9A)NoneNoneNone | 1.45A | 1t03A-3zscA:undetectable | 1t03A-3zscA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4akz | TYPE IV SECRETIONSYSTEM PROTEIN VIRB8 (Brucella suis) |
PF04335(VirB8) | 4 | TYR A 98MET A 102ASP A 103ASP A 99 | None | 1.11A | 1t03A-4akzA:undetectable | 1t03A-4akzA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c4o | CARBONYL REDUCTASECPCR2 (Candidaparapsilosis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | TYR A 61MET A 63ASP A 122HIS A 27 | None | 1.15A | 1t03A-4c4oA:undetectable | 1t03A-4c4oA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cwe | REPLICATIONINITIATION PROTEIN,REPLICATIONINITIATION PROTEIN (Staphylococcusaureus) |
PF02486(Rep_trans) | 4 | TYR A 224MET A 221ASP A 185ASP A 220 | None | 1.44A | 1t03A-4cweA:undetectable | 1t03A-4cweA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e1e | FARNESYLPYROPHOSPHATESYNTHASE (Trypanosomacruzi) |
PF00348(polyprenyl_synt) | 4 | MET A 101ASP A 102ASP A 99LYS A 264 | None MG A 403 (-2.4A)None0MW A 404 ( 3.0A) | 1.16A | 1t03A-4e1eA:undetectable | 1t03A-4e1eA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4em7 | DNA TOPOISOMERASEIV, B SUBUNIT (Streptococcuspneumoniae) |
PF02518(HATPase_c) | 4 | ASP A 54ASP A 50LYS A 122HIS A 43 | None | 1.11A | 1t03A-4em7A:undetectable | 1t03A-4em7A:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fas | HYDROXYLAMINEOXIDOREDUCTASENE1300 (Nitrosomonaseuropaea) |
PF13447(Multi-haem_cyto)no annotation | 4 | MET A 376ASP A 377ASP A 374LYS D 23 | HEC A 606 (-3.9A)NoneEDO A 618 ( 4.1A)None | 1.30A | 1t03A-4fasA:undetectable | 1t03A-4fasA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fo1 | LINCOSAMIDERESISTANCE PROTEIN (Staphylococcushaemolyticus) |
PF10706(Aminoglyc_resit) | 4 | ASP A 48TYR A 88ASP A 90ASP A 46 | EPE A 201 (-3.6A)NoneNoneNone | 1.34A | 1t03A-4fo1A:undetectable | 1t03A-4fo1A:15.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fwt | ELONGATION FACTORTS, ELONGATIONFACTOR TU, LINKER, QBETA REPLICASE (Escherichiacoli;Escherichiavirus Qbeta) |
PF00009(GTP_EFTU)PF00889(EF_TS)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2)PF03431(RNA_replicase_B) | 4 | TYR A1051ASP A1053ASP A1054HIS A1094 | C G2008 ( 4.8A) CA A2502 (-2.7A) CA A2503 (-3.5A)None | 1.32A | 1t03A-4fwtA:5.4 | 1t03A-4fwtA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4grh | AMINODEOXYCHORISMATESYNTHASE (Stenotrophomonasmaltophilia) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 4 | ASP A 429ASP A 283ASP A 284HIS A 335 | MG A 507 ( 4.7A)None MG A 507 (-2.6A)None | 1.30A | 1t03A-4grhA:undetectable | 1t03A-4grhA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ip4 | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME-LIKE PROTEIN (Ruegeria sp.TM1040) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ASP A 246MET A 26ASP A 24LYS A 216 | MG A 503 (-2.6A)NoneGOL A 501 (-3.7A) MG A 503 ( 3.9A) | 1.45A | 1t03A-4ip4A:undetectable | 1t03A-4ip4A:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j0m | SERINE/THREONINE-PROTEIN KINASEBRI1-LIKE 1 (Arabidopsisthaliana) |
PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 4 | ASP A 717ASP A 715ASP A 693HIS A 696 | None | 1.34A | 1t03A-4j0mA:undetectable | 1t03A-4j0mA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jzx | FARNESYLPYROPHOSPHATESYNTHASE (Leishmaniamajor) |
PF00348(polyprenyl_synt) | 4 | MET A 101ASP A 102ASP A 99LYS A 264 | None CA A 403 (-2.5A)None476 A 402 (-2.9A) | 1.31A | 1t03A-4jzxA:undetectable | 1t03A-4jzxA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l8k | PUTATIVE PEPTIDASE (Parabacteroidesmerdae) |
PF03572(Peptidase_S41)PF14684(Tricorn_C1) | 4 | ASP A 50ASP A 53ASP A 52HIS A 208 | None | 1.42A | 1t03A-4l8kA:undetectable | 1t03A-4l8kA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mu9 | GLYCOSIDE HYDROLASEFAMILY 73 (Bacteroidesthetaiotaomicron) |
PF03663(Glyco_hydro_76) | 4 | ASP A 141TYR A 63ASP A 142HIS A 196 | EPE A 408 (-2.9A)EDO A 401 ( 4.9A)EDO A 401 ( 2.7A)None | 1.35A | 1t03A-4mu9A:undetectable | 1t03A-4mu9A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p0v | FARNESYLPYROPHOSPHATESYNTHASE (Homo sapiens) |
PF00348(polyprenyl_synt) | 4 | MET A 106ASP A 107ASP A 104LYS A 257 | None MG A 405 (-2.4A)None1WO A 402 ( 2.8A) | 1.22A | 1t03A-4p0vA:undetectable | 1t03A-4p0vA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pve | POLLEN ALLERGEN PHLP 4.0202 (Phleum pratense) |
PF01565(FAD_binding_4)PF08031(BBE) | 4 | TYR A 486ASP A 485ASP A 482HIS A 200 | None | 1.41A | 1t03A-4pveA:2.8 | 1t03A-4pveA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qtb | MITOGEN-ACTIVATEDPROTEIN KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 4 | ASP A 335ASP A 338LYS A 155HIS A 97 | None | 1.43A | 1t03A-4qtbA:undetectable | 1t03A-4qtbA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9o | PUTATIVE ALDO/KETOREDUCTASE (Salmonellaenterica) |
PF00248(Aldo_ket_red) | 4 | TYR A 21MET A 19ASP A 50HIS A 128 | None | 1.21A | 1t03A-4r9oA:undetectable | 1t03A-4r9oA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tr2 | SUBTILISIN-LIKE 1SERINE PROTEASE (Plasmodiumvivax) |
PF00082(Peptidase_S8) | 4 | MET A 367ASP A 368ASP A 369HIS A 408 | None | 1.22A | 1t03A-4tr2A:undetectable | 1t03A-4tr2A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xrl | MITOGEN-ACTIVATEDPROTEIN KINASE 1 (Rattusnorvegicus) |
PF00069(Pkinase) | 4 | ASP A 316ASP A 319LYS A 136HIS A 78 | None | 1.33A | 1t03A-4xrlA:undetectable | 1t03A-4xrlA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y9s | EPOXIDE HYDROLASE (Solanumtuberosum) |
PF00561(Abhydrolase_1) | 4 | ASP A 64TYR A 62ASP A 58HIS A 6 | None | 1.26A | 1t03A-4y9sA:undetectable | 1t03A-4y9sA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ydq | PROLINE--TRNA LIGASE (Plasmodiumfalciparum) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 4 | ASP A 576ASP A 577LYS A 586HIS A 589 | None | 1.45A | 1t03A-4ydqA:undetectable | 1t03A-4ydqA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z7g | SERINE/THREONINE-PROTEINKINASE/ENDORIBONUCLEASE IRE1 (Homo sapiens) |
PF00069(Pkinase)PF06479(Ribonuc_2-5A) | 4 | ASP A 844ASP A 847LYS A 908HIS A 909 | None | 1.28A | 1t03A-4z7gA:undetectable | 1t03A-4z7gA:21.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5c24 | HIV-1 REVERSETRANSCRIPTASE, P51SUBUNIT (Humanimmunodeficiencyvirus 1) |
PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 4 | ASP B 110MET B 184ASP B 185ASP B 186 | None | 1.43A | 1t03A-5c24B:10.9 | 1t03A-5c24B:96.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5c24 | HIV-1 REVERSETRANSCRIPTASE, P51SUBUNIT (Humanimmunodeficiencyvirus 1) |
PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 4 | ASP B 110MET B 184ASP B 186LYS B 227 | None | 1.39A | 1t03A-5c24B:10.9 | 1t03A-5c24B:96.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5c24 | HIV-1 REVERSETRANSCRIPTASE, P51SUBUNIT (Humanimmunodeficiencyvirus 1) |
PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 4 | TYR B 183MET B 184ASP B 185ASP B 186 | None | 1.09A | 1t03A-5c24B:10.9 | 1t03A-5c24B:96.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ci6 | MITOGEN-ACTIVATEDPROTEIN KINASE 6 (Arabidopsisthaliana) |
PF00069(Pkinase) | 4 | ASP A 353ASP A 356LYS A 178HIS A 119 | None | 1.43A | 1t03A-5ci6A:undetectable | 1t03A-5ci6A:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dbo | TRANSLATIONINITIATION FACTOREIF-2B-LIKE PROTEIN (Chaetomiumthermophilum) |
PF01008(IF-2B) | 4 | ASP A 427TYR A 433MET A 379ASP A 376 | None | 1.33A | 1t03A-5dboA:undetectable | 1t03A-5dboA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fll | 6-CARBOXYHEXANOATE-COA LIGASE (Bacillussubtilis) |
PF03744(BioW) | 4 | ASP A 195TYR A 199ASP A 196HIS A 26 | MG A 704 (-2.7A)WAQ A 700 (-4.6A) MG A 704 (-2.6A)PPV A 701 (-3.8A) | 1.32A | 1t03A-5fllA:undetectable | 1t03A-5fllA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g2h | - (Salmonellaenterica) |
PF00977(His_biosynth) | 4 | ASP A 207ASP A 210ASP A 209LYS A 232 | NoneNoneCME A 241 ( 4.2A)None | 1.04A | 1t03A-5g2hA:undetectable | 1t03A-5g2hA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h71 | ALGQ2 (Sphingomonassp.) |
PF01547(SBP_bac_1) | 4 | TYR A 393ASP A 392ASP A 132HIS A 110 | None | 1.14A | 1t03A-5h71A:undetectable | 1t03A-5h71A:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i85 | SPHINGOMYELINPHOSPHODIESTERASE (Homo sapiens) |
PF00149(Metallophos) | 4 | TYR A 213ASP A 251ASP A 210HIS A 286 | None | 1.10A | 1t03A-5i85A:undetectable | 1t03A-5i85A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5im3 | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (Pseudomonasaeruginosa) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF03477(ATP-cone) | 4 | ASP A 489TYR A 516ASP A 567LYS A 493 | None | 1.46A | 1t03A-5im3A:undetectable | 1t03A-5im3A:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iqk | BETA-LACTAMASE RM3 (unculturedbacterium) |
PF00753(Lactamase_B) | 4 | TYR A 150ASP A 137ASP A 147HIS A 186 | NoneNoneNone ZN A 401 (-3.2A) | 1.45A | 1t03A-5iqkA:undetectable | 1t03A-5iqkA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iqk | BETA-LACTAMASE RM3 (unculturedbacterium) |
PF00753(Lactamase_B) | 4 | TYR A 150ASP A 146ASP A 147HIS A 108 | NoneNoneNone ZN A 401 (-3.2A) | 1.12A | 1t03A-5iqkA:undetectable | 1t03A-5iqkA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iqk | BETA-LACTAMASE RM3 (unculturedbacterium) |
PF00753(Lactamase_B) | 4 | TYR A 150ASP A 146ASP A 147HIS A 186 | NoneNoneNone ZN A 401 (-3.2A) | 1.34A | 1t03A-5iqkA:undetectable | 1t03A-5iqkA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j4r | WELO5 (Hapalosiphonwelwitschii) |
no annotation | 4 | TYR A 224MET A 225ASP A 226ASP A 227 | None | 1.38A | 1t03A-5j4rA:undetectable | 1t03A-5j4rA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jjr | GENOME POLYPROTEIN (Dengue virus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 4 | ASP A 533ASP A 663ASP A 664LYS A 689 | MG A1006 (-3.0A)None MG A1006 (-2.7A)None | 1.47A | 1t03A-5jjrA:4.4 | 1t03A-5jjrA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k5z | PARA (Sulfolobus sp.NOB8H2) |
PF13614(AAA_31) | 4 | ASP A 141MET A 44ASP A 39ASP A 41 | MG A 702 (-3.0A)NoneNone MG A 702 ( 3.4A) | 1.23A | 1t03A-5k5zA:undetectable | 1t03A-5k5zA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m6g | BETA-GLUCOSIDASE (Saccharopolysporaerythraea) |
no annotation | 4 | ASP A 244TYR A 503ASP A 509HIS A 232 | GOL A 709 (-3.1A)None MG A 702 (-3.2A)GOL A 709 ( 3.4A) | 1.43A | 1t03A-5m6gA:2.2 | 1t03A-5m6gA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nqd | ARSENITE OXIDASELARGE SUBUNIT AIOA[3FE-4S] CLUSTER,MO-MOLYBDOPTERINCOFACTOR-BINDINGACTIVE SITE (Rhizobium sp.NT-26) |
no annotation | 4 | ASP A 80TYR A 583MET A 584ASP A 585 | None | 1.40A | 1t03A-5nqdA:undetectable | 1t03A-5nqdA:10.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ovn | POL PROTEIN (Felineimmunodeficiencyvirus) |
no annotation | 4 | ASP A 109TYR A 182MET A 183ASP A 184 | None | 1.05A | 1t03A-5ovnA:20.8 | 1t03A-5ovnA:55.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ovn | POL PROTEIN (Felineimmunodeficiencyvirus) |
no annotation | 4 | ASP A 109TYR A 182MET A 183ASP A 185 | None | 0.95A | 1t03A-5ovnA:20.8 | 1t03A-5ovnA:55.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ovn | POL PROTEIN (Felineimmunodeficiencyvirus) |
no annotation | 4 | ASP B 109MET B 183ASP B 184ASP B 185 | None | 1.31A | 1t03A-5ovnB:8.3 | 1t03A-5ovnB:59.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ovn | POL PROTEIN (Felineimmunodeficiencyvirus) |
no annotation | 4 | TYR B 182MET B 183ASP B 184ASP B 185 | None | 1.22A | 1t03A-5ovnB:8.3 | 1t03A-5ovnB:59.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5td2 | TYROSINE-PROTEINKINASE MER (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | TYR A 676MET A 735ASP A 734ASP A 733 | None | 1.47A | 1t03A-5td2A:undetectable | 1t03A-5td2A:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5veb | CADHERIN-6 (Homo sapiens) |
PF00028(Cadherin) | 4 | ASP X 572TYR X 575ASP X 574HIS X 521 | None | 1.48A | 1t03A-5vebX:undetectable | 1t03A-5vebX:11.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w8d | AUTOINDUCER SYNTHASE (Bradyrhizobiumjaponicum) |
PF00765(Autoind_synth) | 4 | TYR A 48ASP A 50ASP A 49HIS A 20 | MTA A 301 (-4.8A)NoneNoneNone | 1.21A | 1t03A-5w8dA:undetectable | 1t03A-5w8dA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wwl | CENTROMERE PROTEINMIS12KINETOCHORE PROTEINNNF1 (Schizosaccharomycespombe) |
no annotation | 4 | TYR N 110MET M 109ASP M 110ASP M 106 | None | 1.46A | 1t03A-5wwlN:undetectable | 1t03A-5wwlN:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xe0 | GENOME POLYPROTEIN (Enterovirus D) |
PF00680(RdRP_1) | 4 | TYR A 322ASP A 324ASP A 325LYS A 355 | NoneGTP A 501 ( 4.2A)NoneGTP A 501 (-3.5A) | 0.91A | 1t03A-5xe0A:4.2 | 1t03A-5xe0A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xmd | EPOXIDE HYDROLASE A (Vigna radiata) |
no annotation | 4 | ASP A 64TYR A 62ASP A 58HIS A 6 | None | 1.30A | 1t03A-5xmdA:undetectable | 1t03A-5xmdA:9.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwb | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Colwelliapsychrerythraea) |
PF00275(EPSP_synthase) | 4 | ASP A 207ASP A 203LYS A 275HIS A 276 | None | 1.36A | 1t03A-5xwbA:undetectable | 1t03A-5xwbA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b07 | FARNESYL DIPHOSPHATESYNTHASE (Choristoneurafumiferana) |
no annotation | 4 | MET A 150ASP A 151ASP A 148LYS A 301 | None MG A 402 (-2.5A)NoneC6M A 401 (-2.9A) | 1.17A | 1t03A-6b07A:undetectable | 1t03A-6b07A:11.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6em0 | 2-HYDROXYBIPHENYL-3-MONOOXYGENASE (Pseudomonasnitroreducens) |
no annotation | 4 | ASP A 222TYR A 115ASP A 117HIS A 80 | None | 1.37A | 1t03A-6em0A:undetectable | 1t03A-6em0A:10.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6evj | RNA-DIRECTED RNAPOLYMERASE CATALYTICSUBUNIT (Influenza Avirus) |
no annotation | 4 | ASP B 305ASP B 445ASP B 446LYS B 481 | None | 0.96A | 1t03A-6evjB:7.0 | 1t03A-6evjB:8.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f5o | RNA-DIRECTED RNAPOLYMERASE CATALYTICSUBUNIT (Influenza Bvirus) |
no annotation | 4 | ASP B 305ASP B 444ASP B 445LYS B 480 | None | 0.91A | 1t03A-6f5oB:7.3 | 1t03A-6f5oB:9.11 |