SIMILAR PATTERNS OF AMINO ACIDS FOR 1T03_P_TFOP822

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 MET B  49
ASP B  50
LYS C   1
HIS A  27
 None
 0.95A 1t03A-1ffvB:
undetectable		 1t03A-1ffvB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE

(Pyrococcus
horikoshii) 		PF00857
(Isochorismatase) 		4 ASP A  52
TYR A 132
ASP A  10
HIS A  58
 ZN  A 400 (-2.5A)
None
None
None
 1.26A 1t03A-1im5A:
undetectable		 1t03A-1im5A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khw RNA-DIRECTED RNA
POLYMERASE

(Rabbit
hemorrhagic
disease virus) 		PF00680
(RdRP_1) 		4 ASP A 250
TYR A 352
ASP A 354
ASP A 355
 MN  A 602 ( 2.6A)
None
MN  A 601 ( 2.3A)
MN  A 601 (-4.0A)
 0.90A 1t03A-1khwA:
4.9		 1t03A-1khwA:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 ASP A 110
TYR A 183
ASP A 185
ASP A 186
 None
 0.87A 1t03A-1mu2A:
30.7		 1t03A-1mu2A:
60.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 ASP A 110
TYR A 183
ASP A 186
LYS A 220
 None
 0.97A 1t03A-1mu2A:
30.7		 1t03A-1mu2A:
60.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 ASP A 110
TYR A 183
MET A 184
ASP A 185
 None
 1.24A 1t03A-1mu2A:
30.7		 1t03A-1mu2A:
60.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 ASP A 198
MET A 195
ASP A 197
ASP A 237
 None
 1.48A 1t03A-1o5tA:
undetectable		 1t03A-1o5tA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og6 HYPOTHETICAL
OXIDOREDUCTASE YDHF

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 TYR A  21
MET A  19
ASP A  50
HIS A 128
 None
None
NAP  A1298 (-3.6A)
NAP  A1298 (-4.6A)
 1.22A 1t03A-1og6A:
undetectable		 1t03A-1og6A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p32 MITOCHONDRIAL MATRIX
PROTEIN, SF2P32

(Homo sapiens) 		PF02330
(MAM33) 		4 TYR A 236
MET A 240
ASP A 241
ASP A 237
 None
 1.21A 1t03A-1p32A:
undetectable		 1t03A-1p32A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 ASP A 198
MET A 195
ASP A 197
ASP A 237
 None
 1.45A 1t03A-1r6uA:
undetectable		 1t03A-1r6uA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 MET A 110
ASP A 111
ASP A 106
LYS A 258
 None
MG  A 909 (-2.4A)
None
RIS  A 901 (-2.7A)
 1.27A 1t03A-1rqjA:
undetectable		 1t03A-1rqjA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spi FRUCTOSE
1,6-BISPHOSPHATASE

(Spinacia
oleracea) 		PF00316
(FBPase) 		4 TYR A 252
MET A 253
ASP A 254
ASP A 255
 None
 1.26A 1t03A-1spiA:
undetectable		 1t03A-1spiA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w07 ACYL-COA OXIDASE

(Arabidopsis
thaliana) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 ASP A 224
TYR A 234
MET A 237
ASP A 238
 None
FAD  A1660 ( 4.1A)
None
None
 1.32A 1t03A-1w07A:
undetectable		 1t03A-1w07A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		4 TYR A 393
ASP A 392
ASP A 132
HIS A 110
 None
 1.21A 1t03A-1y3nA:
undetectable		 1t03A-1y3nA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bhm TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Brucella suis) 		PF04335
(VirB8) 		4 TYR A  98
MET A 102
ASP A 103
ASP A  99
 None
 1.11A 1t03A-2bhmA:
undetectable		 1t03A-2bhmA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 ASP A 225
TYR A 232
MET A 235
ASP A 236
 None
FAD  A 699 ( 3.8A)
None
None
 1.31A 1t03A-2ddhA:
undetectable		 1t03A-2ddhA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 ASP A 224
TYR A 234
MET A 237
ASP A 238
 None
FAD  A1000 ( 4.2A)
None
None
 1.26A 1t03A-2fonA:
undetectable		 1t03A-2fonA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 ASP A 110
TYR A 183
MET A 184
ASP A 185
 None
 0.74A 1t03A-2hnzA:
34.5		 1t03A-2hnzA:
97.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		4 TYR 1 509
ASP 1 511
ASP 1 512
LYS 1 542
 None
None
None
SO4  1 648 (-3.2A)
 0.98A 1t03A-2ijd1:
3.6		 1t03A-2ijd1:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odf HYPOTHETICAL PROTEIN
ATU2144

(Agrobacterium
fabrum) 		PF05013
(FGase) 		4 TYR A  87
MET A  99
ASP A  88
HIS A 154
 None
 1.30A 1t03A-2odfA:
undetectable		 1t03A-2odfA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		4 ASP A 149
ASP A 143
ASP A 139
HIS A 152
 CA  A 502 ( 3.3A)
CA  A 502 (-2.8A)
CA  A 500 (-2.3A)
None
 1.49A 1t03A-2qpsA:
undetectable		 1t03A-2qpsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 ASP A 496
MET A 447
ASP A 448
HIS A 489
 None
 1.30A 1t03A-2vk9A:
undetectable		 1t03A-2vk9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx8 NUCLEOPORIN-LIKE
PROTEIN RIP,
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7

(Homo sapiens;
Mus musculus) 		PF13774
(Longin) 		4 ASP A 112
TYR A  93
ASP A 111
ASP A 110
 None
 1.44A 1t03A-2vx8A:
undetectable		 1t03A-2vx8A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we9 MOBA-RELATED PROTEIN

(Mycobacterium
tuberculosis) 		PF12804
(NTP_transf_3) 		4 ASP A 181
ASP A 183
ASP A 105
HIS A 137
 None
None
GOL  A1196 (-3.4A)
None
 1.41A 1t03A-2we9A:
undetectable		 1t03A-2we9A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 TYR A 233
ASP A 230
ASP A 231
HIS A  95
 PLP  A1427 (-4.9A)
PLP  A1427 (-2.8A)
None
None
 1.18A 1t03A-2xh1A:
2.7		 1t03A-2xh1A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 TYR A 688
ASP A 774
ASP A 687
HIS A1304
 None
 1.16A 1t03A-2zxqA:
undetectable		 1t03A-2zxqA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2b SERINE
PALMITOYLTRANSFERASE

(Sphingobacterium
multivorum) 		PF00155
(Aminotran_1_2) 		4 ASP A 181
ASP A 210
ASP A 137
HIS A 157
 PLP  A 400 (-3.8A)
PLP  A 400 (-2.6A)
None
None
 1.35A 1t03A-3a2bA:
3.0		 1t03A-3a2bA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay3 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Chromohalobacter
salexigens) 		PF01370
(Epimerase) 		4 ASP A 227
MET A 185
ASP A 182
ASP A 183
 None
 1.47A 1t03A-3ay3A:
undetectable		 1t03A-3ay3A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5r BRCA1-ASSOCIATED
RING DOMAIN PROTEIN
1

(Homo sapiens) 		PF12796
(Ank_2) 		4 ASP A 500
TYR A 492
ASP A 495
HIS A 471
 None
 1.19A 1t03A-3c5rA:
undetectable		 1t03A-3c5rA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		4 TYR A 128
MET A 157
ASP A 160
LYS A 167
 None
 1.46A 1t03A-3douA:
undetectable		 1t03A-3douA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etv PROTEIN TRANSPORT
PROTEIN TIP20,
PROTEIN TRANSPORT
PROTEIN DSL1 CHIMERA

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		4 TYR A 168
MET A 172
ASP A 173
ASP A 169
 None
 0.96A 1t03A-3etvA:
undetectable		 1t03A-3etvA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbg PUTATIVE ARGINATE
LYASE

(Staphylococcus
haemolyticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A 279
ASP A 278
LYS A 282
HIS A 283
 None
 1.48A 1t03A-3fbgA:
undetectable		 1t03A-3fbgA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF00579
(tRNA-synt_1b) 		4 ASP A 115
MET A 112
ASP A 114
ASP A 154
 None
 1.47A 1t03A-3i05A:
undetectable		 1t03A-3i05A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io1 AMINOBENZOYL-GLUTAMA
TE UTILIZATION
PROTEIN

(Klebsiella
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASP A 151
ASP A 118
ASP A 116
HIS A 208
 NA  A 501 (-2.0A)
NA  A 501 ( 4.9A)
NA  A 501 (-3.0A)
None
 1.28A 1t03A-3io1A:
3.6		 1t03A-3io1A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k93 PHAGE RELATED
EXONUCLEASE

(Histophilus
somni) 		no annotation 4 ASP A  99
TYR A 136
ASP A 110
LYS A  84
 NA  A 223 (-2.8A)
PEG  A 228 (-4.5A)
NA  A 223 (-2.9A)
None
 1.43A 1t03A-3k93A:
undetectable		 1t03A-3k93A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1

(Homo sapiens) 		PF00899
(ThiF) 		4 ASP A 239
TYR A 161
MET A 334
ASP A 332
 EDO  A 347 (-3.9A)
None
None
None
 1.48A 1t03A-3kydA:
undetectable		 1t03A-3kydA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1

(Homo sapiens) 		PF00899
(ThiF) 		4 ASP A 239
TYR A 294
MET A 334
ASP A 332
 EDO  A 347 (-3.9A)
None
None
None
 1.32A 1t03A-3kydA:
undetectable		 1t03A-3kydA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN

(Escherichia
virus Qbeta) 		no annotation 4 TYR G 357
ASP G 359
ASP G 360
HIS G 400
 None
 1.43A 1t03A-3mmpG:
2.1		 1t03A-3mmpG:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf2 PUTATIVE POLYPRENYL
SYNTHETASE

(Streptomyces
coelicolor) 		PF00348
(polyprenyl_synt) 		4 ASP A 134
MET A 131
ASP A 132
ASP A 129
 None
None
SO4  A   3 (-4.2A)
None
 1.47A 1t03A-3nf2A:
undetectable		 1t03A-3nf2A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ASP A 503
TYR A 457
ASP A 502
HIS A 481
 None
NAG  A1004 (-3.9A)
NAG  A1004 (-3.8A)
None
 1.46A 1t03A-3o6nA:
undetectable		 1t03A-3o6nA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		4 MET B 945
ASP B 946
ASP B 947
HIS B 914
 None
 1.39A 1t03A-3qd2B:
undetectable		 1t03A-3qd2B:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmc UNCHARACTERIZED
PROTEIN

(Bdellovibrio
bacteriovorus) 		PF13487
(HD_5) 		4 MET A 267
ASP A 268
LYS A 145
HIS A 149
 None
DMS  A 312 (-4.0A)
None
DMS  A 312 (-4.0A)
 1.00A 1t03A-3tmcA:
undetectable		 1t03A-3tmcA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		4 TYR A  73
ASP A 143
ASP A  77
HIS A 378
 None
None
None
GOL  A 505 (-4.3A)
 1.49A 1t03A-3wc3A:
undetectable		 1t03A-3wc3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsc PECTATE
TRISACCHARIDE-LYASE

(Thermotoga
maritima) 		PF00544
(Pec_lyase_C) 		4 ASP A 139
ASP A 115
ASP A 117
HIS A 161
 AQA  A1338 (-3.9A)
None
None
None
 1.45A 1t03A-3zscA:
undetectable		 1t03A-3zscA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Brucella suis) 		PF04335
(VirB8) 		4 TYR A  98
MET A 102
ASP A 103
ASP A  99
 None
 1.11A 1t03A-4akzA:
undetectable		 1t03A-4akzA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4o CARBONYL REDUCTASE
CPCR2

(Candida
parapsilosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 TYR A  61
MET A  63
ASP A 122
HIS A  27
 None
 1.15A 1t03A-4c4oA:
undetectable		 1t03A-4c4oA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cwe REPLICATION
INITIATION PROTEIN,
REPLICATION
INITIATION PROTEIN

(Staphylococcus
aureus) 		PF02486
(Rep_trans) 		4 TYR A 224
MET A 221
ASP A 185
ASP A 220
 None
 1.44A 1t03A-4cweA:
undetectable		 1t03A-4cweA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		4 MET A 101
ASP A 102
ASP A  99
LYS A 264
 None
MG  A 403 (-2.4A)
None
0MW  A 404 ( 3.0A)
 1.16A 1t03A-4e1eA:
undetectable		 1t03A-4e1eA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em7 DNA TOPOISOMERASE
IV, B SUBUNIT

(Streptococcus
pneumoniae) 		PF02518
(HATPase_c) 		4 ASP A  54
ASP A  50
LYS A 122
HIS A  43
 None
 1.11A 1t03A-4em7A:
undetectable		 1t03A-4em7A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fas HYDROXYLAMINE
OXIDOREDUCTASE
NE1300

(Nitrosomonas
europaea) 		PF13447
(Multi-haem_cyto)
no annotation 		4 MET A 376
ASP A 377
ASP A 374
LYS D  23
 HEC  A 606 (-3.9A)
None
EDO  A 618 ( 4.1A)
None
 1.30A 1t03A-4fasA:
undetectable		 1t03A-4fasA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo1 LINCOSAMIDE
RESISTANCE PROTEIN

(Staphylococcus
haemolyticus) 		PF10706
(Aminoglyc_resit) 		4 ASP A  48
TYR A  88
ASP A  90
ASP A  46
 EPE  A 201 (-3.6A)
None
None
None
 1.34A 1t03A-4fo1A:
undetectable		 1t03A-4fo1A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		4 TYR A1051
ASP A1053
ASP A1054
HIS A1094
 C  G2008 ( 4.8A)
CA  A2502 (-2.7A)
CA  A2503 (-3.5A)
None
 1.32A 1t03A-4fwtA:
5.4		 1t03A-4fwtA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE

(Stenotrophomonas
maltophilia) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ASP A 429
ASP A 283
ASP A 284
HIS A 335
 MG  A 507 ( 4.7A)
None
MG  A 507 (-2.6A)
None
 1.30A 1t03A-4grhA:
undetectable		 1t03A-4grhA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 246
MET A  26
ASP A  24
LYS A 216
 MG  A 503 (-2.6A)
None
GOL  A 501 (-3.7A)
MG  A 503 ( 3.9A)
 1.45A 1t03A-4ip4A:
undetectable		 1t03A-4ip4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ASP A 717
ASP A 715
ASP A 693
HIS A 696
 None
 1.34A 1t03A-4j0mA:
undetectable		 1t03A-4j0mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		4 MET A 101
ASP A 102
ASP A  99
LYS A 264
 None
CA  A 403 (-2.5A)
None
476  A 402 (-2.9A)
 1.31A 1t03A-4jzxA:
undetectable		 1t03A-4jzxA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8k PUTATIVE PEPTIDASE

(Parabacteroides
merdae) 		PF03572
(Peptidase_S41)
PF14684
(Tricorn_C1) 		4 ASP A  50
ASP A  53
ASP A  52
HIS A 208
 None
 1.42A 1t03A-4l8kA:
undetectable		 1t03A-4l8kA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mu9 GLYCOSIDE HYDROLASE
FAMILY 73

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		4 ASP A 141
TYR A  63
ASP A 142
HIS A 196
 EPE  A 408 (-2.9A)
EDO  A 401 ( 4.9A)
EDO  A 401 ( 2.7A)
None
 1.35A 1t03A-4mu9A:
undetectable		 1t03A-4mu9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		4 MET A 106
ASP A 107
ASP A 104
LYS A 257
 None
MG  A 405 (-2.4A)
None
1WO  A 402 ( 2.8A)
 1.22A 1t03A-4p0vA:
undetectable		 1t03A-4p0vA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum pratense) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 TYR A 486
ASP A 485
ASP A 482
HIS A 200
 None
 1.41A 1t03A-4pveA:
2.8		 1t03A-4pveA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A 335
ASP A 338
LYS A 155
HIS A  97
 None
 1.43A 1t03A-4qtbA:
undetectable		 1t03A-4qtbA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		4 TYR A  21
MET A  19
ASP A  50
HIS A 128
 None
 1.21A 1t03A-4r9oA:
undetectable		 1t03A-4r9oA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE

(Plasmodium
vivax) 		PF00082
(Peptidase_S8) 		4 MET A 367
ASP A 368
ASP A 369
HIS A 408
 None
 1.22A 1t03A-4tr2A:
undetectable		 1t03A-4tr2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 ASP A 316
ASP A 319
LYS A 136
HIS A  78
 None
 1.33A 1t03A-4xrlA:
undetectable		 1t03A-4xrlA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		4 ASP A  64
TYR A  62
ASP A  58
HIS A   6
 None
 1.26A 1t03A-4y9sA:
undetectable		 1t03A-4y9sA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 ASP A 576
ASP A 577
LYS A 586
HIS A 589
 None
 1.45A 1t03A-4ydqA:
undetectable		 1t03A-4ydqA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 ASP A 844
ASP A 847
LYS A 908
HIS A 909
 None
 1.28A 1t03A-4z7gA:
undetectable		 1t03A-4z7gA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 ASP B 110
MET B 184
ASP B 185
ASP B 186
 None
 1.43A 1t03A-5c24B:
10.9		 1t03A-5c24B:
96.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 ASP B 110
MET B 184
ASP B 186
LYS B 227
 None
 1.39A 1t03A-5c24B:
10.9		 1t03A-5c24B:
96.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 TYR B 183
MET B 184
ASP B 185
ASP B 186
 None
 1.09A 1t03A-5c24B:
10.9		 1t03A-5c24B:
96.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 ASP A 353
ASP A 356
LYS A 178
HIS A 119
 None
 1.43A 1t03A-5ci6A:
undetectable		 1t03A-5ci6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		4 ASP A 427
TYR A 433
MET A 379
ASP A 376
 None
 1.33A 1t03A-5dboA:
undetectable		 1t03A-5dboA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fll 6-CARBOXYHEXANOATE-C
OA LIGASE

(Bacillus
subtilis) 		PF03744
(BioW) 		4 ASP A 195
TYR A 199
ASP A 196
HIS A  26
 MG  A 704 (-2.7A)
WAQ  A 700 (-4.6A)
MG  A 704 (-2.6A)
PPV  A 701 (-3.8A)
 1.32A 1t03A-5fllA:
undetectable		 1t03A-5fllA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2h -

(Salmonella
enterica) 		PF00977
(His_biosynth) 		4 ASP A 207
ASP A 210
ASP A 209
LYS A 232
 None
None
CME  A 241 ( 4.2A)
None
 1.04A 1t03A-5g2hA:
undetectable		 1t03A-5g2hA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		4 TYR A 393
ASP A 392
ASP A 132
HIS A 110
 None
 1.14A 1t03A-5h71A:
undetectable		 1t03A-5h71A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		4 TYR A 213
ASP A 251
ASP A 210
HIS A 286
 None
 1.10A 1t03A-5i85A:
undetectable		 1t03A-5i85A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 ASP A 489
TYR A 516
ASP A 567
LYS A 493
 None
 1.46A 1t03A-5im3A:
undetectable		 1t03A-5im3A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqk BETA-LACTAMASE RM3

(uncultured
bacterium) 		PF00753
(Lactamase_B) 		4 TYR A 150
ASP A 137
ASP A 147
HIS A 186
 None
None
None
ZN  A 401 (-3.2A)
 1.45A 1t03A-5iqkA:
undetectable		 1t03A-5iqkA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqk BETA-LACTAMASE RM3

(uncultured
bacterium) 		PF00753
(Lactamase_B) 		4 TYR A 150
ASP A 146
ASP A 147
HIS A 108
 None
None
None
ZN  A 401 (-3.2A)
 1.12A 1t03A-5iqkA:
undetectable		 1t03A-5iqkA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqk BETA-LACTAMASE RM3

(uncultured
bacterium) 		PF00753
(Lactamase_B) 		4 TYR A 150
ASP A 146
ASP A 147
HIS A 186
 None
None
None
ZN  A 401 (-3.2A)
 1.34A 1t03A-5iqkA:
undetectable		 1t03A-5iqkA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4r WELO5

(Hapalosiphon
welwitschii) 		no annotation 4 TYR A 224
MET A 225
ASP A 226
ASP A 227
 None
 1.38A 1t03A-5j4rA:
undetectable		 1t03A-5j4rA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 ASP A 533
ASP A 663
ASP A 664
LYS A 689
 MG  A1006 (-3.0A)
None
MG  A1006 (-2.7A)
None
 1.47A 1t03A-5jjrA:
4.4		 1t03A-5jjrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5z PARA

(Sulfolobus sp.
NOB8H2) 		PF13614
(AAA_31) 		4 ASP A 141
MET A  44
ASP A  39
ASP A  41
 MG  A 702 (-3.0A)
None
None
MG  A 702 ( 3.4A)
 1.23A 1t03A-5k5zA:
undetectable		 1t03A-5k5zA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 4 ASP A 244
TYR A 503
ASP A 509
HIS A 232
 GOL  A 709 (-3.1A)
None
MG  A 702 (-3.2A)
GOL  A 709 ( 3.4A)
 1.43A 1t03A-5m6gA:
2.2		 1t03A-5m6gA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 ASP A  80
TYR A 583
MET A 584
ASP A 585
 None
 1.40A 1t03A-5nqdA:
undetectable		 1t03A-5nqdA:
10.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 4 ASP A 109
TYR A 182
MET A 183
ASP A 184
 None
 1.05A 1t03A-5ovnA:
20.8		 1t03A-5ovnA:
55.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 4 ASP A 109
TYR A 182
MET A 183
ASP A 185
 None
 0.95A 1t03A-5ovnA:
20.8		 1t03A-5ovnA:
55.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 4 ASP B 109
MET B 183
ASP B 184
ASP B 185
 None
 1.31A 1t03A-5ovnB:
8.3		 1t03A-5ovnB:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 4 TYR B 182
MET B 183
ASP B 184
ASP B 185
 None
 1.22A 1t03A-5ovnB:
8.3		 1t03A-5ovnB:
59.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 676
MET A 735
ASP A 734
ASP A 733
 None
 1.47A 1t03A-5td2A:
undetectable		 1t03A-5td2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veb CADHERIN-6

(Homo sapiens) 		PF00028
(Cadherin) 		4 ASP X 572
TYR X 575
ASP X 574
HIS X 521
 None
 1.48A 1t03A-5vebX:
undetectable		 1t03A-5vebX:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8d AUTOINDUCER SYNTHASE

(Bradyrhizobium
japonicum) 		PF00765
(Autoind_synth) 		4 TYR A  48
ASP A  50
ASP A  49
HIS A  20
 MTA  A 301 (-4.8A)
None
None
None
 1.21A 1t03A-5w8dA:
undetectable		 1t03A-5w8dA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwl CENTROMERE PROTEIN
MIS12
KINETOCHORE PROTEIN
NNF1

(Schizosaccharomyces
pombe) 		no annotation 4 TYR N 110
MET M 109
ASP M 110
ASP M 106
 None
 1.46A 1t03A-5wwlN:
undetectable		 1t03A-5wwlN:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		4 TYR A 322
ASP A 324
ASP A 325
LYS A 355
 None
GTP  A 501 ( 4.2A)
None
GTP  A 501 (-3.5A)
 0.91A 1t03A-5xe0A:
4.2		 1t03A-5xe0A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata) 		no annotation 4 ASP A  64
TYR A  62
ASP A  58
HIS A   6
 None
 1.30A 1t03A-5xmdA:
undetectable		 1t03A-5xmdA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		4 ASP A 207
ASP A 203
LYS A 275
HIS A 276
 None
 1.36A 1t03A-5xwbA:
undetectable		 1t03A-5xwbA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 4 MET A 150
ASP A 151
ASP A 148
LYS A 301
 None
MG  A 402 (-2.5A)
None
C6M  A 401 (-2.9A)
 1.17A 1t03A-6b07A:
undetectable		 1t03A-6b07A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 4 ASP A 222
TYR A 115
ASP A 117
HIS A  80
 None
 1.37A 1t03A-6em0A:
undetectable		 1t03A-6em0A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 ASP B 305
ASP B 445
ASP B 446
LYS B 481
 None
 0.96A 1t03A-6evjB:
7.0		 1t03A-6evjB:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus) 		no annotation 4 ASP B 305
ASP B 444
ASP B 445
LYS B 480
 None
 0.91A 1t03A-6f5oB:
7.3		 1t03A-6f5oB:
9.11