SIMILAR PATTERNS OF AMINO ACIDS FOR 1SV5_A_65BA600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Drosophila
melanogaster) 		PF00274
(Glycolytic) 		5 LEU A 209
VAL A 264
VAL A 186
PRO A 294
LEU A 256
 None
 1.25A 1sv5A-1fbaA:
0.0		 1sv5A-1fbaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		5 LEU A1209
VAL A1264
VAL A1186
PRO A1294
LEU A1256
 None
 1.31A 1sv5A-1fdjA:
0.0		 1sv5A-1fdjA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnn CELL DIVISION
CONTROL PROTEIN 6

(Pyrobaculum
aerophilum) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 LEU A 246
VAL A   8
VAL A   3
TYR A 214
PRO A  15
 None
None
None
None
ADP  A 398 (-4.7A)
 1.46A 1sv5A-1fnnA:
0.0		 1sv5A-1fnnA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
PRO A 225
TRP A 229
LEU A 234
TYR A 318
 None
 0.94A 1sv5A-1mu2A:
28.7		 1sv5A-1mu2A:
60.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
PRO A 226
TRP A 229
LEU A 234
TYR A 318
 None
 1.37A 1sv5A-1mu2A:
28.7		 1sv5A-1mu2A:
60.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A 276
VAL A 285
VAL A 234
PRO A 288
LEU A 290
 None
 1.35A 1sv5A-1muuA:
0.0		 1sv5A-1muuA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 LEU A 239
LYS A 238
TYR A 213
TRP A  88
LEU A  60
 None
 1.43A 1sv5A-1qhgA:
0.0		 1sv5A-1qhgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shx EPHRIN-A5

(Mus musculus) 		PF00812
(Ephrin) 		5 LEU A 159
LYS A 160
VAL A  56
LEU A  62
TYR A 142
 None
 1.39A 1sv5A-1shxA:
undetectable		 1sv5A-1shxA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp9 PEROXIREDOXIN

(Populus
trichocarpa) 		PF08534
(Redoxin) 		5 LEU A  15
LYS A  14
VAL A  33
LEU A  40
TYR A 108
 None
 1.47A 1sv5A-1tp9A:
undetectable		 1sv5A-1tp9A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens) 		PF00274
(Glycolytic) 		5 LEU A 210
VAL A 265
VAL A 187
PRO A 295
LEU A 257
 None
 1.34A 1sv5A-1xfbA:
0.0		 1sv5A-1xfbA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN A1 CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		5 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.18A 1sv5A-1yhuA:
1.6		 1sv5A-1yhuA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		5 LEU A 194
LYS A 195
VAL A 156
TYR A 153
TYR A 213
 None
 1.44A 1sv5A-2grmA:
undetectable		 1sv5A-2grmA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		6 LEU A 100
LYS A 101
PRO A 226
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
None
None
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 1.14A 1sv5A-2hnzA:
35.6		 1sv5A-2hnzA:
97.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		8 LEU A 100
LYS A 101
VAL A 106
VAL A 179
TYR A 181
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.88A 1sv5A-2hnzA:
35.6		 1sv5A-2hnzA:
97.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
LYS A 101
VAL A 106
VAL A 179
TYR A 181
TYR A 188
TRP A 229
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.2A)
 0.99A 1sv5A-2hnzA:
35.6		 1sv5A-2hnzA:
97.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 TYR A 181
PRO A 225
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 (-3.9A)
None
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.96A 1sv5A-2hnzA:
35.6		 1sv5A-2hnzA:
97.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		5 LEU A  63
VAL A  95
VAL A  60
PRO A 112
LEU A  90
 None
 1.24A 1sv5A-2iuyA:
undetectable		 1sv5A-2iuyA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 381
LYS A 382
VAL A 283
LEU A 428
TYR A 385
 None
 1.47A 1sv5A-2jiiA:
undetectable		 1sv5A-2jiiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		5 LEU A 209
VAL A 264
VAL A 186
PRO A 294
LEU A 256
 None
 1.30A 1sv5A-3bv4A:
undetectable		 1sv5A-3bv4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ft9 PHL P 3 ALLERGEN

(Phleum pratense) 		PF01357
(Pollen_allerg_1) 		5 LEU A  19
VAL A  82
VAL A   4
TYR A  93
PRO A  64
 None
 1.38A 1sv5A-3ft9A:
undetectable		 1sv5A-3ft9A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8r PROBABLE SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
E

(Chromobacterium
violaceum) 		PF03102
(NeuB)
PF08666
(SAF) 		5 LEU A 338
VAL A 299
VAL A 288
LEU A 310
TYR A 321
 None
 1.46A 1sv5A-3g8rA:
undetectable		 1sv5A-3g8rA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD
CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis;
Bacillus
anthracis) 		no annotation
no annotation 		5 LEU L 273
VAL L 261
VAL L 328
TYR L 256
LEU S 441
 None
 1.33A 1sv5A-3g9kL:
undetectable		 1sv5A-3g9kL:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 LEU A 543
VAL A 526
VAL A 582
TYR A 549
LEU A 520
 None
 1.36A 1sv5A-3k30A:
undetectable		 1sv5A-3k30A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE

(Cryptosporidium
parvum) 		PF00121
(TIM) 		5 LEU A 238
LYS A 239
VAL A  39
VAL A 233
LEU A  20
 None
 1.50A 1sv5A-3krsA:
undetectable		 1sv5A-3krsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxq UNCHARACTERIZED
PROTEIN VP1736

(Vibrio
parahaemolyticus) 		PF00884
(Sulfatase) 		5 LEU A 422
LYS A 425
VAL A 401
TYR A 379
TYR A 423
 None
 1.39A 1sv5A-3lxqA:
undetectable		 1sv5A-3lxqA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		5 LEU A 203
VAL A 257
VAL A 177
PRO A 286
LEU A 249
 None
 1.31A 1sv5A-3mmtA:
0.6		 1sv5A-3mmtA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quc INORGANIC
PYROPHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		5 LEU A 157
LYS A 158
VAL A 138
TYR A 153
LEU A   9
 None
 1.36A 1sv5A-3qucA:
2.1		 1sv5A-3qucA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE

(Maricaulis
maris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		5 LEU A 348
VAL A 412
VAL A 423
LEU A 433
TYR A 353
 None
 1.29A 1sv5A-3s6hA:
undetectable		 1sv5A-3s6hA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 LEU A 155
VAL A 113
VAL A  96
TYR A 102
TYR A 153
 None
 1.27A 1sv5A-3va6A:
undetectable		 1sv5A-3va6A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqo UNCHARACTERIZED
PROTEIN MJ1311

(Methanocaldococcus
jannaschii) 		PF01261
(AP_endonuc_2) 		5 LEU A 187
VAL A 118
VAL A 115
PRO A  86
LEU A 142
 None
 1.25A 1sv5A-3wqoA:
undetectable		 1sv5A-3wqoA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpd ALCOHOL
DEHYDROGENASE

(Thermus sp.
ATN1) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 154
VAL A 295
TYR A 158
PRO A 139
LEU A 306
 None
 1.44A 1sv5A-4cpdA:
undetectable		 1sv5A-4cpdA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LEU A1056
LYS A1057
VAL A 763
LEU A 740
TYR A1055
 None
 1.37A 1sv5A-4ddwA:
undetectable		 1sv5A-4ddwA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlq LATROPHILIN-1

(Rattus
norvegicus) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		5 LEU A 651
VAL A 679
VAL A 620
TRP A 636
LEU A 733
 None
 1.41A 1sv5A-4dlqA:
0.5		 1sv5A-4dlqA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sus scrofa) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 LEU A 108
VAL A 154
VAL A 147
TRP A  73
LEU A  54
 None
 1.29A 1sv5A-4i9aA:
4.5		 1sv5A-4i9aA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgg ESTERASE TESA

(Pseudomonas
aeruginosa) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 176
TYR A  35
TYR A  37
PRO A  65
LEU A  67
 None
 1.17A 1sv5A-4jggA:
undetectable		 1sv5A-4jggA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lps HYDROGENASE/UREASE
NICKEL INCORPORATION
PROTEIN HYPB

(Helicobacter
pylori) 		PF02492
(cobW) 		5 LEU A 204
LYS A 205
VAL A 197
VAL A 179
LEU A 167
 None
MLI  A 309 (-3.3A)
None
None
None
 1.46A 1sv5A-4lpsA:
undetectable		 1sv5A-4lpsA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		5 LEU A  91
VAL A 220
VAL A  82
TRP A  72
LEU A 229
 None
 1.35A 1sv5A-4q2cA:
undetectable		 1sv5A-4q2cA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7k ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 LEU A 427
LYS A 428
VAL A 463
TYR A 459
LEU A 478
 None
 1.27A 1sv5A-4q7kA:
1.5		 1sv5A-4q7kA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qan HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		no annotation 5 LEU A  68
LYS A  69
VAL A  61
VAL A 147
LEU A 203
 None
 1.48A 1sv5A-4qanA:
undetectable		 1sv5A-4qanA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woy MITOCHONDRIAL
DYNAMICS PROTEIN
MID49

(Mus musculus) 		PF03281
(Mab-21) 		5 LEU A 197
VAL A 194
TYR A 335
PRO A 321
LEU A 318
 None
 1.48A 1sv5A-4woyA:
undetectable		 1sv5A-4woyA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 LEU A1112
PRO A1142
TRP A1151
LEU A1138
TYR A1113
 None
 1.07A 1sv5A-5kf7A:
1.6		 1sv5A-5kf7A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		5 LEU A1584
LYS A1583
VAL A1512
LEU A1495
TYR A1585
 None
 1.33A 1sv5A-5lkzA:
1.3		 1sv5A-5lkzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26

(Saccharomyces
cerevisiae) 		no annotation 5 LEU M 488
LYS M 487
VAL M 461
PRO M 348
LEU M 350
 None
 1.21A 1sv5A-5vvrM:
undetectable		 1sv5A-5vvrM:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Sus scrofa) 		no annotation 5 LEU E  20
VAL E  60
VAL E  28
TYR E  26
LEU E 103
 None
 1.18A 1sv5A-6exvE:
undetectable		 1sv5A-6exvE:
undetectable