SIMILAR PATTERNS OF AMINO ACIDS FOR 1SS4_A_ACTA411_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE


(Thermus
thermophilus)
PF01293
(PEPCK_ATP)
4 TRP A 309
VAL A 298
THR A 318
ILE A 284
None
1.02A 1ss4A-1j3bA:
0.0
1ss4A-1j3bA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1joi AZURIN

(Pseudomonas
fluorescens)
PF00127
(Copper-bind)
4 TRP A  48
VAL A  95
THR A  96
ILE A  22
TRP  A  48 ( 0.4A)
VAL  A  95 ( 0.6A)
THR  A  96 ( 0.8A)
ILE  A  22 ( 0.7A)
1.31A 1ss4A-1joiA:
0.0
1ss4A-1joiA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER


(Rhinella
arenarum)
PF14651
(Lipocalin_7)
4 VAL A  80
THR A  81
GLN A  83
ILE A  99
None
1.31A 1ss4A-1p6pA:
0.6
1ss4A-1p6pA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
4 VAL A 103
THR A 102
GLN A  49
ILE A  56
None
1.29A 1ss4A-1q8iA:
0.9
1ss4A-1q8iA:
12.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ss4 GLYOXALASE FAMILY
PROTEIN


(Bacillus cereus)
PF13669
(Glyoxalase_4)
5 TRP A  43
VAL A  47
THR A  48
GLN A  53
ILE A  57
None
ACT  A 411 (-4.1A)
ACT  A 411 (-4.6A)
ACT  A 411 ( 4.4A)
None
0.00A 1ss4A-1ss4A:
27.0
1ss4A-1ss4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 VAL A 352
THR A 351
GLN A 435
ILE A 334
None
0.86A 1ss4A-1xdiA:
0.7
1ss4A-1xdiA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsf PROBABLE
RESUSCITATION-PROMOT
ING FACTOR RPFB


(Mycobacterium
tuberculosis)
PF06737
(Transglycosylas)
4 TRP A  95
THR A  89
GLN A  93
ILE A  34
None
1.43A 1ss4A-1xsfA:
undetectable
1ss4A-1xsfA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f91 HEPATOPANCREAS
TRYPSIN


(Astacus
leptodactylus)
PF00089
(Trypsin)
4 VAL A 138
THR A 139
GLN A  30
ILE A 121
None
1.39A 1ss4A-2f91A:
0.0
1ss4A-2f91A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2giy GLYCOPROTEIN E

(Human
alphaherpesvirus
1)
PF02480
(Herpes_gE)
4 TRP A 262
VAL A 244
THR A 228
ILE A 375
None
1.38A 1ss4A-2giyA:
0.0
1ss4A-2giyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj7 GLYCOPROTEIN E

(Human
alphaherpesvirus
1)
no annotation 4 TRP F 262
VAL F 244
THR F 228
ILE F 375
None
1.37A 1ss4A-2gj7F:
0.0
1ss4A-2gj7F:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A


(Escherichia
coli)
PF00171
(Aldedh)
4 VAL A 212
THR A 211
GLN A  42
ILE A  24
None
1.23A 1ss4A-2iluA:
undetectable
1ss4A-2iluA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa)
PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc)
4 VAL A 400
THR A 251
GLN A 169
ILE A 157
None
1.35A 1ss4A-2vz9A:
undetectable
1ss4A-2vz9A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq9 PREDICTED ROSSMANN
FOLD
NUCLEOTIDE-BINDING
DOMAIN-CONTAINING
PROTEIN


(Idiomarina
baltica)
PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478)
4 VAL A 128
THR A 125
GLN A 356
ILE A 267
None
1.36A 1ss4A-3bq9A:
0.0
1ss4A-3bq9A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edl KINESIN13 MOTOR
DOMAIN


(Drosophila
melanogaster)
PF00225
(Kinesin)
4 VAL D 213
THR D 214
GLN D 289
ILE D 150
None
1.45A 1ss4A-3edlD:
0.6
1ss4A-3edlD:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN


(Homo sapiens)
PF00089
(Trypsin)
4 VAL H 138
THR H 139
GLN H  30
ILE H 121
None
1.32A 1ss4A-3f6uH:
undetectable
1ss4A-3f6uH:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1


(Candida
parapsilosis)
PF00026
(Asp)
4 VAL A 278
THR A 277
GLN A 327
ILE A 325
None
1.01A 1ss4A-3fv3A:
1.9
1ss4A-3fv3A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gym PROSTASIN

(Homo sapiens)
PF00089
(Trypsin)
4 VAL A 138
THR A 139
GLN A  30
ILE A 121
None
1.48A 1ss4A-3gymA:
undetectable
1ss4A-3gymA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h25 REPLICATION PROTEIN
B


(Plasmid RSF1010)
PF16793
(RepB_primase)
4 VAL A 166
THR A 100
GLN A 106
ILE A  63
None
1.44A 1ss4A-3h25A:
undetectable
1ss4A-3h25A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER


(Ruegeria
pomeroyi)
PF13458
(Peripla_BP_6)
4 TRP A 236
VAL A 253
GLN A 261
ILE A 231
None
1.41A 1ss4A-3h5lA:
undetectable
1ss4A-3h5lA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbc CHOLOYLGLYCINE
HYDROLASE


(Bacteroides
thetaiotaomicron)
PF02275
(CBAH)
4 VAL A  30
THR A  40
GLN A 287
ILE A 169
None
1.23A 1ss4A-3hbcA:
undetectable
1ss4A-3hbcA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0c E2 ENVELOPE
GLYCOPROTEIN


(Venezuelan
equine
encephalitis
virus)
PF00943
(Alpha_E2_glycop)
4 VAL B 237
THR B  12
GLN B  52
ILE B  74
None
0.95A 1ss4A-3j0cB:
undetectable
1ss4A-3j0cB:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfv TIGHT JUNCTION
PROTEIN ZO-3


(Homo sapiens)
PF00625
(Guanylate_kin)
PF07653
(SH3_2)
4 VAL A 709
THR A 754
GLN A 777
ILE A 782
None
1.13A 1ss4A-3kfvA:
undetectable
1ss4A-3kfvA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL


(Homo sapiens)
PF00067
(p450)
4 VAL A 392
THR A 393
GLN A 395
ILE A 123
2DC  A 602 ( 4.7A)
2DC  A 602 ( 4.7A)
2DC  A 602 (-3.0A)
None
1.49A 1ss4A-3na0A:
0.9
1ss4A-3na0A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfe PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE FAMILY
PROTEIN


(Coccidioides
immitis)
PF00701
(DHDPS)
4 VAL A  15
THR A  16
GLN A  30
ILE A 275
None
1.11A 1ss4A-3qfeA:
undetectable
1ss4A-3qfeA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
4 TRP A 162
VAL A 148
THR A 137
ILE A 183
None
1.26A 1ss4A-3sunA:
undetectable
1ss4A-3sunA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB


(Bacillus
anthracis)
PF04183
(IucA_IucC)
PF06276
(FhuF)
4 VAL A  63
THR A  64
GLN A  54
ILE A  38
None
1.15A 1ss4A-3to3A:
undetectable
1ss4A-3to3A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE


(Escherichia
coli)
PF00291
(PALP)
4 TRP A 192
VAL A 172
THR A 175
ILE A 198
None
1.28A 1ss4A-4d9iA:
0.3
1ss4A-4d9iA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN


(Legionella
drancourtii)
no annotation 4 TRP A 351
VAL A 368
THR A 365
ILE A 480
None
1.38A 1ss4A-4jvsA:
undetectable
1ss4A-4jvsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldy AUXIN RESPONSE
FACTOR 1


(Arabidopsis
thaliana)
PF02362
(B3)
PF06507
(Auxin_resp)
4 TRP A  24
VAL A  32
THR A  33
ILE A  95
None
1.48A 1ss4A-4ldyA:
undetectable
1ss4A-4ldyA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xv0 BETA-XYLANASE

(Trichoderma
reesei)
PF00331
(Glyco_hydro_10)
4 VAL A 311
THR A 310
GLN A  87
ILE A  81
None
1.44A 1ss4A-4xv0A:
undetectable
1ss4A-4xv0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgz ANTIZYME INHIBITOR 1

(Homo sapiens)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
4 TRP A  55
VAL A  58
GLN A  61
ILE A 234
None
1.01A 1ss4A-4zgzA:
undetectable
1ss4A-4zgzA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26


(Bacteroides
ovatus)
PF02156
(Glyco_hydro_26)
4 TRP A 304
VAL A 322
THR A 293
ILE A 355
None
1.43A 1ss4A-4zxoA:
undetectable
1ss4A-4zxoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2


(Saccharomyces
cerevisiae)
PF04427
(Brix)
4 VAL C 135
THR C 134
GLN C 179
ILE C 226
None
1.34A 1ss4A-5a53C:
undetectable
1ss4A-5a53C:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doz JAMJ

(Lyngbya
majuscula)
PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2)
4 TRP A  21
THR A  72
GLN A   7
ILE A  38
None
1.30A 1ss4A-5dozA:
undetectable
1ss4A-5dozA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN


(Homo sapiens)
PF00089
(Trypsin)
4 VAL A 138
THR A 139
GLN A  30
ILE A 121
None
1.37A 1ss4A-5f8zA:
undetectable
1ss4A-5f8zA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus)
no annotation 4 VAL A 138
THR A 139
GLN A  30
ILE A 121
None
1.36A 1ss4A-5gvtA:
undetectable
1ss4A-5gvtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA
NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT BETA


(Pyrococcus
furiosus;
Pyrococcus
furiosus)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF10418
(DHODB_Fe-S_bind)
4 VAL S 239
THR S 234
GLN S 258
ILE L 265
None
1.32A 1ss4A-5jfcS:
undetectable
1ss4A-5jfcS:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms3 KALLIKREIN-8

(Homo sapiens)
no annotation 4 VAL A 138
THR A 137
GLN A  27
ILE A 121
None
1.28A 1ss4A-5ms3A:
undetectable
1ss4A-5ms3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu3 CENTRAL KINETOCHORE
SUBUNIT CTF19


(Kluyveromyces
lactis)
no annotation 4 VAL E 223
THR E 242
GLN E 246
ILE E 253
None
1.46A 1ss4A-5mu3E:
undetectable
1ss4A-5mu3E:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans)
PF03568
(Peptidase_C50)
4 TRP 1 676
THR 1 680
GLN 1 723
ILE 1 732
None
1.20A 1ss4A-5mz61:
undetectable
1ss4A-5mz61:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 4 VAL B 238
THR B 239
GLN B 136
ILE B 165
None
1.07A 1ss4A-5n5nB:
undetectable
1ss4A-5n5nB:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sui RIBOSOME BIOGENESIS
PROTEIN NSA1


(Saccharomyces
cerevisiae)
no annotation 4 VAL A 347
THR A 341
GLN A 310
ILE A 409
None
1.15A 1ss4A-5suiA:
undetectable
1ss4A-5suiA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz0 FLUORESCENCE
RECOVERY PROTEIN


(Tolypothrix sp.
PCC 7601)
no annotation 4 VAL A  75
THR A  78
GLN A  82
ILE A  61
None
1.44A 1ss4A-5tz0A:
undetectable
1ss4A-5tz0A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjp CYCLOHEXADIENYL
DEHYDRATASE


(Candidatus
Pelagibacter
ubique)
PF00497
(SBP_bac_3)
4 VAL A 112
THR A 111
GLN A 144
ILE A 136
None
1.27A 1ss4A-5wjpA:
undetectable
1ss4A-5wjpA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxl RIBOSOME BIOGENESIS
PROTEIN RPF2


(Saccharomyces
cerevisiae)
PF04427
(Brix)
4 VAL A 135
THR A 134
GLN A 179
ILE A 226
None
1.32A 1ss4A-5wxlA:
undetectable
1ss4A-5wxlA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4)
PF01270
(Glyco_hydro_8)
4 TRP A 139
VAL A  93
THR A  92
GLN A 141
None
1.47A 1ss4A-5xd0A:
undetectable
1ss4A-5xd0A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4


(Mus musculus)
no annotation 4 TRP B 681
VAL B 776
THR B 777
ILE B 708
None
1.30A 1ss4A-6bcqB:
undetectable
1ss4A-6bcqB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE


(Legionella
pneumophila)
no annotation 4 VAL A 330
THR A 267
GLN A  11
ILE A 344
None
1.33A 1ss4A-6bs7A:
undetectable
1ss4A-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus)
no annotation 4 VAL A1637
THR A1638
GLN A2571
ILE A1899
None
1.22A 1ss4A-6fb3A:
1.1
1ss4A-6fb3A:
undetectable