SIMILAR PATTERNS OF AMINO ACIDS FOR 1SS4_A_ACTA411_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3b | ATP-DEPENDENTPHOSPHOENOLPYRUVATECARBOXYKINASE (Thermusthermophilus) |
PF01293(PEPCK_ATP) | 4 | TRP A 309VAL A 298THR A 318ILE A 284 | None | 1.02A | 1ss4A-1j3bA:0.0 | 1ss4A-1j3bA:14.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1joi | AZURIN (Pseudomonasfluorescens) |
PF00127(Copper-bind) | 4 | TRP A 48VAL A 95THR A 96ILE A 22 | TRP A 48 ( 0.4A)VAL A 95 ( 0.6A)THR A 96 ( 0.8A)ILE A 22 ( 0.7A) | 1.31A | 1ss4A-1joiA:0.0 | 1ss4A-1joiA:24.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p6p | FATTY ACID-BINDINGPROTEIN, LIVER (Rhinellaarenarum) |
PF14651(Lipocalin_7) | 4 | VAL A 80THR A 81GLN A 83ILE A 99 | None | 1.31A | 1ss4A-1p6pA:0.6 | 1ss4A-1p6pA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8i | DNA POLYMERASE II (Escherichiacoli) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | VAL A 103THR A 102GLN A 49ILE A 56 | None | 1.29A | 1ss4A-1q8iA:0.9 | 1ss4A-1q8iA:12.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ss4 | GLYOXALASE FAMILYPROTEIN (Bacillus cereus) |
PF13669(Glyoxalase_4) | 5 | TRP A 43VAL A 47THR A 48GLN A 53ILE A 57 | NoneACT A 411 (-4.1A)ACT A 411 (-4.6A)ACT A 411 ( 4.4A)None | 0.00A | 1ss4A-1ss4A:27.0 | 1ss4A-1ss4A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xdi | RV3303C-LPDA (Mycobacteriumtuberculosis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | VAL A 352THR A 351GLN A 435ILE A 334 | None | 0.86A | 1ss4A-1xdiA:0.7 | 1ss4A-1xdiA:15.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xsf | PROBABLERESUSCITATION-PROMOTING FACTOR RPFB (Mycobacteriumtuberculosis) |
PF06737(Transglycosylas) | 4 | TRP A 95THR A 89GLN A 93ILE A 34 | None | 1.43A | 1ss4A-1xsfA:undetectable | 1ss4A-1xsfA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f91 | HEPATOPANCREASTRYPSIN (Astacusleptodactylus) |
PF00089(Trypsin) | 4 | VAL A 138THR A 139GLN A 30ILE A 121 | None | 1.39A | 1ss4A-2f91A:0.0 | 1ss4A-2f91A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2giy | GLYCOPROTEIN E (Humanalphaherpesvirus1) |
PF02480(Herpes_gE) | 4 | TRP A 262VAL A 244THR A 228ILE A 375 | None | 1.38A | 1ss4A-2giyA:0.0 | 1ss4A-2giyA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gj7 | GLYCOPROTEIN E (Humanalphaherpesvirus1) |
no annotation | 4 | TRP F 262VAL F 244THR F 228ILE F 375 | None | 1.37A | 1ss4A-2gj7F:0.0 | 1ss4A-2gj7F:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ilu | ALDEHYDEDEHYDROGENASE A (Escherichiacoli) |
PF00171(Aldedh) | 4 | VAL A 212THR A 211GLN A 42ILE A 24 | None | 1.23A | 1ss4A-2iluA:undetectable | 1ss4A-2iluA:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vz9 | FATTY ACID SYNTHASE (Sus scrofa) |
PF00107(ADH_zinc_N)PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08242(Methyltransf_12)PF08659(KR)PF14765(PS-DH)PF16197(KAsynt_C_assoc) | 4 | VAL A 400THR A 251GLN A 169ILE A 157 | None | 1.35A | 1ss4A-2vz9A:undetectable | 1ss4A-2vz9A:5.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bq9 | PREDICTED ROSSMANNFOLDNUCLEOTIDE-BINDINGDOMAIN-CONTAININGPROTEIN (Idiomarinabaltica) |
PF03641(Lysine_decarbox)PF11892(DUF3412)PF14793(DUF4478) | 4 | VAL A 128THR A 125GLN A 356ILE A 267 | None | 1.36A | 1ss4A-3bq9A:0.0 | 1ss4A-3bq9A:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3edl | KINESIN13 MOTORDOMAIN (Drosophilamelanogaster) |
PF00225(Kinesin) | 4 | VAL D 213THR D 214GLN D 289ILE D 150 | None | 1.45A | 1ss4A-3edlD:0.6 | 1ss4A-3edlD:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f6u | VITAMIN K-DEPENDENTPROTEIN C HEAVYCHAIN (Homo sapiens) |
PF00089(Trypsin) | 4 | VAL H 138THR H 139GLN H 30ILE H 121 | None | 1.32A | 1ss4A-3f6uH:undetectable | 1ss4A-3f6uH:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fv3 | SAPP1P-SECRETEDASPARTIC PROTEASE 1 (Candidaparapsilosis) |
PF00026(Asp) | 4 | VAL A 278THR A 277GLN A 327ILE A 325 | None | 1.01A | 1ss4A-3fv3A:1.9 | 1ss4A-3fv3A:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gym | PROSTASIN (Homo sapiens) |
PF00089(Trypsin) | 4 | VAL A 138THR A 139GLN A 30ILE A 121 | None | 1.48A | 1ss4A-3gymA:undetectable | 1ss4A-3gymA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h25 | REPLICATION PROTEINB (Plasmid RSF1010) |
PF16793(RepB_primase) | 4 | VAL A 166THR A 100GLN A 106ILE A 63 | None | 1.44A | 1ss4A-3h25A:undetectable | 1ss4A-3h25A:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5l | PUTATIVEBRANCHED-CHAIN AMINOACID ABC TRANSPORTER (Ruegeriapomeroyi) |
PF13458(Peripla_BP_6) | 4 | TRP A 236VAL A 253GLN A 261ILE A 231 | None | 1.41A | 1ss4A-3h5lA:undetectable | 1ss4A-3h5lA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbc | CHOLOYLGLYCINEHYDROLASE (Bacteroidesthetaiotaomicron) |
PF02275(CBAH) | 4 | VAL A 30THR A 40GLN A 287ILE A 169 | None | 1.23A | 1ss4A-3hbcA:undetectable | 1ss4A-3hbcA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j0c | E2 ENVELOPEGLYCOPROTEIN (Venezuelanequineencephalitisvirus) |
PF00943(Alpha_E2_glycop) | 4 | VAL B 237THR B 12GLN B 52ILE B 74 | None | 0.95A | 1ss4A-3j0cB:undetectable | 1ss4A-3j0cB:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kfv | TIGHT JUNCTIONPROTEIN ZO-3 (Homo sapiens) |
PF00625(Guanylate_kin)PF07653(SH3_2) | 4 | VAL A 709THR A 754GLN A 777ILE A 782 | None | 1.13A | 1ss4A-3kfvA:undetectable | 1ss4A-3kfvA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3na0 | CHOLESTEROLSIDE-CHAIN CLEAVAGEENZYME,MITOCHONDRIAL (Homo sapiens) |
PF00067(p450) | 4 | VAL A 392THR A 393GLN A 395ILE A 123 | 2DC A 602 ( 4.7A)2DC A 602 ( 4.7A)2DC A 602 (-3.0A)None | 1.49A | 1ss4A-3na0A:0.9 | 1ss4A-3na0A:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfe | PUTATIVEDIHYDRODIPICOLINATESYNTHASE FAMILYPROTEIN (Coccidioidesimmitis) |
PF00701(DHDPS) | 4 | VAL A 15THR A 16GLN A 30ILE A 275 | None | 1.11A | 1ss4A-3qfeA:undetectable | 1ss4A-3qfeA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sun | DNA POLYMERASE (Escherichiavirus RB69) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | TRP A 162VAL A 148THR A 137ILE A 183 | None | 1.26A | 1ss4A-3sunA:undetectable | 1ss4A-3sunA:11.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3to3 | PETROBACTINBIOSYNTHESIS PROTEINASBB (Bacillusanthracis) |
PF04183(IucA_IucC)PF06276(FhuF) | 4 | VAL A 63THR A 64GLN A 54ILE A 38 | None | 1.15A | 1ss4A-3to3A:undetectable | 1ss4A-3to3A:13.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d9i | DIAMINOPROPIONATEAMMONIA-LYASE (Escherichiacoli) |
PF00291(PALP) | 4 | TRP A 192VAL A 172THR A 175ILE A 198 | None | 1.28A | 1ss4A-4d9iA:0.3 | 1ss4A-4d9iA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jvs | PUTATIVEUNCHARACTERIZEDPROTEIN (Legionelladrancourtii) |
no annotation | 4 | TRP A 351VAL A 368THR A 365ILE A 480 | None | 1.38A | 1ss4A-4jvsA:undetectable | 1ss4A-4jvsA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ldy | AUXIN RESPONSEFACTOR 1 (Arabidopsisthaliana) |
PF02362(B3)PF06507(Auxin_resp) | 4 | TRP A 24VAL A 32THR A 33ILE A 95 | None | 1.48A | 1ss4A-4ldyA:undetectable | 1ss4A-4ldyA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xv0 | BETA-XYLANASE (Trichodermareesei) |
PF00331(Glyco_hydro_10) | 4 | VAL A 311THR A 310GLN A 87ILE A 81 | None | 1.44A | 1ss4A-4xv0A:undetectable | 1ss4A-4xv0A:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgz | ANTIZYME INHIBITOR 1 (Homo sapiens) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 4 | TRP A 55VAL A 58GLN A 61ILE A 234 | None | 1.01A | 1ss4A-4zgzA:undetectable | 1ss4A-4zgzA:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxo | GLYCOSYL HYDROLASEFAMILY 26 (Bacteroidesovatus) |
PF02156(Glyco_hydro_26) | 4 | TRP A 304VAL A 322THR A 293ILE A 355 | None | 1.43A | 1ss4A-4zxoA:undetectable | 1ss4A-4zxoA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a53 | RIBOSOME BIOGENESISPROTEIN RPF2 (Saccharomycescerevisiae) |
PF04427(Brix) | 4 | VAL C 135THR C 134GLN C 179ILE C 226 | None | 1.34A | 1ss4A-5a53C:undetectable | 1ss4A-5a53C:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5doz | JAMJ (Lyngbyamajuscula) |
PF08240(ADH_N)PF13602(ADH_zinc_N_2) | 4 | TRP A 21THR A 72GLN A 7ILE A 38 | None | 1.30A | 1ss4A-5dozA:undetectable | 1ss4A-5dozA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f8z | PLASMA KALLIKREINLIGHT CHAIN (Homo sapiens) |
PF00089(Trypsin) | 4 | VAL A 138THR A 139GLN A 30ILE A 121 | None | 1.37A | 1ss4A-5f8zA:undetectable | 1ss4A-5f8zA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gvt | PLASMA KALLIKREIN (Mus musculus) |
no annotation | 4 | VAL A 138THR A 139GLN A 30ILE A 121 | None | 1.36A | 1ss4A-5gvtA:undetectable | 1ss4A-5gvtA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfc | NADH-DEPENDENTFERREDOXIN:NADPOXIDOREDUCTASESUBUNIT ALPHANADH-DEPENDENTFERREDOXIN:NADPOXIDOREDUCTASESUBUNIT BETA (Pyrococcusfuriosus;Pyrococcusfuriosus) |
PF07992(Pyr_redox_2)PF14691(Fer4_20)PF10418(DHODB_Fe-S_bind) | 4 | VAL S 239THR S 234GLN S 258ILE L 265 | None | 1.32A | 1ss4A-5jfcS:undetectable | 1ss4A-5jfcS:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ms3 | KALLIKREIN-8 (Homo sapiens) |
no annotation | 4 | VAL A 138THR A 137GLN A 27ILE A 121 | None | 1.28A | 1ss4A-5ms3A:undetectable | 1ss4A-5ms3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mu3 | CENTRAL KINETOCHORESUBUNIT CTF19 (Kluyveromyceslactis) |
no annotation | 4 | VAL E 223THR E 242GLN E 246ILE E 253 | None | 1.46A | 1ss4A-5mu3E:undetectable | 1ss4A-5mu3E:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mz6 | SEPARASE (Caenorhabditiselegans) |
PF03568(Peptidase_C50) | 4 | TRP 1 676THR 1 680GLN 1 723ILE 1 732 | None | 1.20A | 1ss4A-5mz61:undetectable | 1ss4A-5mz61:7.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 4 | VAL B 238THR B 239GLN B 136ILE B 165 | None | 1.07A | 1ss4A-5n5nB:undetectable | 1ss4A-5n5nB:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sui | RIBOSOME BIOGENESISPROTEIN NSA1 (Saccharomycescerevisiae) |
no annotation | 4 | VAL A 347THR A 341GLN A 310ILE A 409 | None | 1.15A | 1ss4A-5suiA:undetectable | 1ss4A-5suiA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tz0 | FLUORESCENCERECOVERY PROTEIN (Tolypothrix sp.PCC 7601) |
no annotation | 4 | VAL A 75THR A 78GLN A 82ILE A 61 | None | 1.44A | 1ss4A-5tz0A:undetectable | 1ss4A-5tz0A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wjp | CYCLOHEXADIENYLDEHYDRATASE (CandidatusPelagibacterubique) |
PF00497(SBP_bac_3) | 4 | VAL A 112THR A 111GLN A 144ILE A 136 | None | 1.27A | 1ss4A-5wjpA:undetectable | 1ss4A-5wjpA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wxl | RIBOSOME BIOGENESISPROTEIN RPF2 (Saccharomycescerevisiae) |
PF04427(Brix) | 4 | VAL A 135THR A 134GLN A 179ILE A 226 | None | 1.32A | 1ss4A-5wxlA:undetectable | 1ss4A-5wxlA:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xd0 | GLUCANASE (Paenibacillussp. X4) |
PF01270(Glyco_hydro_8) | 4 | TRP A 139VAL A 93THR A 92GLN A 141 | None | 1.47A | 1ss4A-5xd0A:undetectable | 1ss4A-5xd0A:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bcq | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY MMEMBER 4 (Mus musculus) |
no annotation | 4 | TRP B 681VAL B 776THR B 777ILE B 708 | None | 1.30A | 1ss4A-6bcqB:undetectable | 1ss4A-6bcqB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bs7 | ADENYLOSUCCINATESYNTHETASE (Legionellapneumophila) |
no annotation | 4 | VAL A 330THR A 267GLN A 11ILE A 344 | None | 1.33A | 1ss4A-6bs7A:undetectable | 1ss4A-6bs7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fb3 | TENEURIN-2 (Gallus gallus) |
no annotation | 4 | VAL A1637THR A1638GLN A2571ILE A1899 | None | 1.22A | 1ss4A-6fb3A:1.1 | 1ss4A-6fb3A:undetectable |