SIMILAR PATTERNS OF AMINO ACIDS FOR 1SQN_B_NDRB2001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP

(Salmonella
enterica) 		PF00102
(Y_phosphatase)
PF03545
(YopE) 		5 LEU S 218
LEU S 227
ASN S 228
LEU S 280
LEU S 234
 None
 1.12A 1sqnB-1g4uS:
undetectable		 1sqnB-1g4uS:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 LEU A 244
ASN A 245
LEU A 248
GLN A 252
LEU A  61
 None
 1.07A 1sqnB-1g8kA:
undetectable		 1sqnB-1g8kA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Homo sapiens) 		PF01536
(SAM_decarbox) 		5 LEU A  97
LEU A  94
LEU A  91
MET A  70
LEU A  44
 None
 1.16A 1sqnB-1jl0A:
undetectable		 1sqnB-1jl0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE

(Bacillus
anthracis) 		PF00809
(Pterin_bind) 		5 LEU A 203
LEU A 206
ASN A 207
LEU A 209
LEU A 214
 None
None
None
None
HH2  A 282 ( 4.9A)
 1.16A 1sqnB-1twwA:
undetectable		 1sqnB-1twwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5l TRP REPRESSOR
BINDING PROTEIN WRBA

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		5 LEU A 133
LEU A 130
MET A  84
LEU A   9
LEU A  88
 None
 1.02A 1sqnB-2a5lA:
undetectable		 1sqnB-2a5lA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aja ANKYRIN REPEAT
FAMILY PROTEIN

(Legionella
pneumophila) 		no annotation 5 LEU A 322
ASN A 320
LEU A 325
LEU A 301
LEU A 337
 None
 1.13A 1sqnB-2ajaA:
undetectable		 1sqnB-2ajaA:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 701
LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 742
MET A 745
LEU A 873
 None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-4.4A)
 0.73A 1sqnB-2ax9A:
34.7		 1sqnB-2ax9A:
53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 707
GLN A 711
MET A 742
MET A 745
MET A 787
LEU A 873
 BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.4A)
 1.10A 1sqnB-2ax9A:
34.7		 1sqnB-2ax9A:
53.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A 369
LEU A 368
GLN A 128
LEU A 147
LEU A 377
 None
 0.95A 1sqnB-2dkkA:
undetectable		 1sqnB-2dkkA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4o XP-C REPAIR
COMPLEMENTING
COMPLEX 58 KDA
PROTEIN

(Mus musculus) 		PF09280
(XPC-binding) 		5 LEU B 314
LEU B 313
LEU B 302
MET B 288
LEU B 328
 None
 1.15A 1sqnB-2f4oB:
undetectable		 1sqnB-2f4oB:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 265
LEU A 268
LEU A 271
MET A 306
LEU A 345
 None
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.9A)
OHT  A 500 (-4.3A)
 0.51A 1sqnB-2gpvA:
25.6		 1sqnB-2gpvA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz6 N-ACETYL-D-GLUCOSAMI
NE 2-EPIMERASE

(Anabaena sp.
CH1) 		PF07221
(GlcNAc_2-epim) 		5 LEU A   5
LEU A   8
LEU A  11
LEU A 313
TYR A 317
 None
 0.91A 1sqnB-2gz6A:
undetectable		 1sqnB-2gz6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 253
LEU A 229
LEU A 205
MET A 216
LEU A 236
 None
 1.09A 1sqnB-2id5A:
undetectable		 1sqnB-2id5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		5 LEU A 160
LEU A 136
LEU A 112
LEU A 146
LEU A 143
 None
 1.04A 1sqnB-2o6qA:
undetectable		 1sqnB-2o6qA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6s VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF11921
(DUF3439)
PF12799
(LRR_4)
PF13855
(LRR_8) 		5 LEU A 104
LEU A  80
LEU A  56
LEU A  90
LEU A  87
 None
 1.06A 1sqnB-2o6sA:
undetectable		 1sqnB-2o6sA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6s VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF11921
(DUF3439)
PF12799
(LRR_4)
PF13855
(LRR_8) 		5 LEU A 128
LEU A 104
LEU A  80
LEU A 114
LEU A 111
 None
 1.07A 1sqnB-2o6sA:
undetectable		 1sqnB-2o6sA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6s VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF11921
(DUF3439)
PF12799
(LRR_4)
PF13855
(LRR_8) 		5 LEU A 152
LEU A 128
LEU A 104
LEU A 138
LEU A 135
 None
 1.03A 1sqnB-2o6sA:
undetectable		 1sqnB-2o6sA:
24.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		10 LEU A  29
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
LEU A 111
MET A 115
LEU A 201
CYH A 205
 1CA  A 247 ( 3.6A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
None
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
1CA  A 247 (-4.0A)
 0.69A 1sqnB-2q3yA:
37.5		 1sqnB-2q3yA:
62.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		10 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
MET A 115
LEU A 201
CYH A 205
 1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
1CA  A 247 (-4.0A)
 0.47A 1sqnB-2q3yA:
37.5		 1sqnB-2q3yA:
62.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  35
LEU A  32
LEU A  29
LEU A  77
MET A 115
LEU A  90
 1CA  A 247 ( 4.4A)
1CA  A 247 (-4.0A)
1CA  A 247 ( 3.6A)
1CA  A 247 ( 3.9A)
1CA  A 247 ( 3.7A)
None
 1.19A 1sqnB-2q3yA:
37.5		 1sqnB-2q3yA:
62.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 LEU A 372
LEU A 375
LEU A 378
GLN A 382
LEU A 521
 None
 0.87A 1sqnB-2qveA:
undetectable		 1sqnB-2qveA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 269
LEU A 272
MET A 251
LEU A 229
LEU A 227
 None
 1.12A 1sqnB-2z81A:
undetectable		 1sqnB-2z81A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adr PUTATIVE
UNCHARACTERIZED
PROTEIN ST1585

(Sulfurisphaera
tokodaii) 		PF00753
(Lactamase_B) 		5 LEU A  94
LEU A  97
ASN A  98
LEU A 119
LEU A  67
 EDO  A 265 ( 4.5A)
None
None
EDO  A 265 ( 4.7A)
EDO  A 265 ( 4.4A)
 1.14A 1sqnB-3adrA:
undetectable		 1sqnB-3adrA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE

(Methanocaldococcus
jannaschii) 		PF03587
(EMG1) 		5 LEU A  62
LEU A  63
LEU A  88
MET A 107
LEU A  12
 None
 1.16A 1sqnB-3bbhA:
undetectable		 1sqnB-3bbhA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crj TRANSCRIPTION
REGULATOR

(Haloarcula
marismortui) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 LEU A  59
LEU A  58
MET A  17
LEU A 107
LEU A  66
 None
 0.90A 1sqnB-3crjA:
undetectable		 1sqnB-3crjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A

(Homo sapiens) 		PF00620
(RhoGAP) 		5 LEU A  15
LEU A  12
LEU A   9
LEU A 137
CYH A 161
 None
 1.11A 1sqnB-3eapA:
undetectable		 1sqnB-3eapA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es5 PUTATIVE CAPSID
PROTEIN

(Penicillium
stoloniferum
virus F) 		no annotation 6 LEU A 272
LEU A 275
LEU A 300
LEU A 250
LEU A 255
TYR A 258
 None
 1.06A 1sqnB-3es5A:
undetectable		 1sqnB-3es5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd9 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF16806
(ExsD) 		5 LEU A 236
LEU A 239
LEU A 124
MET A 119
LEU A 226
 None
 1.11A 1sqnB-3fd9A:
undetectable		 1sqnB-3fd9A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3b VARIABLE LYMPHOCYTE
RECEPTOR VLRB.2D

(Petromyzon
marinus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A  82
LEU A  58
LEU A  34
LEU A  68
LEU A  65
 None
 1.07A 1sqnB-3g3bA:
undetectable		 1sqnB-3g3bA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 715
ASN A 719
LEU A 721
GLN A 725
MET A 756
MET A 759
MET A 801
LEU A 887
CYH A 891
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
 0.60A 1sqnB-3kbaA:
40.2		 1sqnB-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 715
LEU A 718
ASN A 719
LEU A 721
MET A 756
MET A 759
MET A 801
LEU A 887
TYR A 890
CYH A 891
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.9A)
WOW  A   1 (-3.5A)
 0.37A 1sqnB-3kbaA:
40.2		 1sqnB-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 721
LEU A 718
LEU A 715
LEU A 763
MET A 801
LEU A 776
 WOW  A   1 ( 4.3A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-4.2A)
None
 1.11A 1sqnB-3kbaA:
40.2		 1sqnB-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 MET A 756
MET A 759
LEU A 797
LEU A 887
TYR A 890
CYH A 891
 WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 ( 4.5A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.9A)
WOW  A   1 (-3.5A)
 0.73A 1sqnB-3kbaA:
40.2		 1sqnB-3kbaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnq PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIC COMPONENT

(Bacillus cereus) 		PF02378
(PTS_EIIC) 		5 ASN A 345
LEU A 304
MET A 308
LEU A 419
TYR A 415
 None
 1.11A 1sqnB-3qnqA:
undetectable		 1sqnB-3qnqA:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		8 LEU A  29
ASN A  33
GLN A  39
MET A  70
LEU A 111
MET A 115
LEU A 201
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
None
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
 0.79A 1sqnB-3ry9A:
36.9		 1sqnB-3ry9A:
61.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
MET A 115
LEU A 201
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
 0.56A 1sqnB-3ry9A:
36.9		 1sqnB-3ry9A:
61.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		6 LEU A  35
LEU A  32
LEU A  29
LEU A  77
MET A 115
LEU A  90
 1CA  A 249 ( 4.4A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
None
 1.23A 1sqnB-3ry9A:
36.9		 1sqnB-3ry9A:
61.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1

(Paenarthrobacter
aurescens) 		PF00962
(A_deaminase) 		5 LEU A 273
ASN A 274
LEU A 237
LEU A 265
CYH A 276
 None
 1.12A 1sqnB-3rysA:
undetectable		 1sqnB-3rysA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twi VARIABLE LYMPHOCYTE
RECEPTOR B

(Petromyzon
marinus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU D 102
LEU D  78
LEU D  54
LEU D  88
LEU D  85
 None
 0.96A 1sqnB-3twiD:
undetectable		 1sqnB-3twiD:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgo MESO-DIAMINOPIMELATE
DEHYDROGENASE

(Clostridium
tetani) 		PF16654
(DAPDH_C) 		5 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 0.94A 1sqnB-3wgoA:
undetectable		 1sqnB-3wgoA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am9 CHAPERONE SYCD

(Yersinia
enterocolitica) 		PF07720
(TPR_3) 		5 LEU A  36
LEU A  39
LEU A  42
GLN A  46
CYH A  63
 None
 0.72A 1sqnB-4am9A:
undetectable		 1sqnB-4am9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3g DNA-BINDING PROTEIN
SMUBP-2

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		5 LEU A 166
LEU A 209
LEU A 390
LEU A 155
TYR A 158
 None
 1.12A 1sqnB-4b3gA:
undetectable		 1sqnB-4b3gA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehj PHOSPHOGLYCERATE
KINASE

(Francisella
tularensis) 		PF00162
(PGK) 		5 LEU A 198
LEU A 201
ASN A 202
LEU A 204
LEU A 246
 None
 0.91A 1sqnB-4ehjA:
undetectable		 1sqnB-4ehjA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 LEU A 114
LEU A 117
LEU A 120
LEU A 103
LEU A 164
 None
None
MLY  A 119 ( 4.6A)
None
MLY  A 138 ( 4.3A)
 0.99A 1sqnB-4f6eA:
undetectable		 1sqnB-4f6eA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glp MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Homo sapiens) 		PF13516
(LRR_6) 		5 LEU A 227
LEU A 199
LEU A 175
LEU A 212
LEU A 207
 None
 1.04A 1sqnB-4glpA:
undetectable		 1sqnB-4glpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus) 		PF01636
(APH) 		5 LEU A 221
LEU A 257
LEU A 110
LEU A 185
CYH A 186
 None
 1.13A 1sqnB-4h05A:
undetectable		 1sqnB-4h05A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes) 		PF02016
(Peptidase_S66) 		5 LEU A 205
LEU A 208
ASN A 209
LEU A 211
LEU A 225
 None
 1.09A 1sqnB-4injA:
undetectable		 1sqnB-4injA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		no annotation 5 LEU B  83
LEU B  59
LEU B  35
LEU B  69
LEU B  66
 None
 1.01A 1sqnB-4k5uB:
undetectable		 1sqnB-4k5uB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		no annotation 5 LEU B 107
LEU B  83
LEU B  59
LEU B  93
LEU B  90
 None
 0.97A 1sqnB-4k5uB:
undetectable		 1sqnB-4k5uB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		no annotation 5 LEU B 131
LEU B 107
LEU B  83
LEU B 117
LEU B 114
 None
 1.08A 1sqnB-4k5uB:
undetectable		 1sqnB-4k5uB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		5 LEU B 438
LEU B 441
GLN B 445
LEU B 130
CYH B 163
 None
 1.03A 1sqnB-4mbgB:
undetectable		 1sqnB-4mbgB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1
SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF01764
(Lipase_3)
PF01764
(Lipase_3) 		5 LEU B 171
LEU A 258
LEU A 255
LEU B  22
LEU B 220
 None
 1.12A 1sqnB-4nfuB:
undetectable		 1sqnB-4nfuB:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 564
GLN A 570
MET A 601
MET A 646
LEU A 732
TYR A 735
CYH A 736
 MOF  A 801 (-3.0A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-4.8A)
MOF  A 801 (-3.7A)
 0.51A 1sqnB-4p6wA:
36.1		 1sqnB-4p6wA:
54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
MET A 646
LEU A 732
CYH A 736
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
 0.57A 1sqnB-4p6wA:
36.1		 1sqnB-4p6wA:
54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 563
LEU A 566
GLN A 570
MET A 601
MET A 604
MET A 646
LEU A 732
 MOF  A 801 (-3.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
 0.85A 1sqnB-4p6wA:
36.1		 1sqnB-4p6wA:
54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 566
LEU A 563
MET A 639
LEU A 608
MET A 646
LEU A 621
 MOF  A 801 ( 4.6A)
MOF  A 801 (-3.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.4A)
None
 1.28A 1sqnB-4p6wA:
36.1		 1sqnB-4p6wA:
54.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po4 LAMPETRA PLANERI
VLRC

(Lampetra
planeri) 		PF13855
(LRR_8) 		5 LEU A  93
LEU A  69
LEU A  45
LEU A  79
LEU A  76
 None
 1.03A 1sqnB-4po4A:
undetectable		 1sqnB-4po4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po4 LAMPETRA PLANERI
VLRC

(Lampetra
planeri) 		PF13855
(LRR_8) 		5 LEU A 117
LEU A  93
LEU A  69
LEU A 103
LEU A 100
 None
 1.00A 1sqnB-4po4A:
undetectable		 1sqnB-4po4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxa SMALL G PROTEIN
SIGNALING MODULATOR
1

(Mus musculus) 		no annotation 5 LEU B 320
LEU B 370
LEU B 371
LEU B 326
LEU B 363
 None
 1.17A 1sqnB-4qxaB:
undetectable		 1sqnB-4qxaB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 137
LEU A 113
LEU A  89
LEU A 123
LEU A 120
 None
 1.09A 1sqnB-4r5dA:
undetectable		 1sqnB-4r5dA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 209
LEU A 185
LEU A 161
LEU A 195
LEU A 192
 None
 1.05A 1sqnB-4r5dA:
undetectable		 1sqnB-4r5dA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 233
LEU A 209
LEU A 185
LEU A 219
LEU A 216
 None
 1.13A 1sqnB-4r5dA:
undetectable		 1sqnB-4r5dA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6f LEUCINE RICH REPEAT
DLRR_I

(synthetic
construct) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A 137
LEU A 113
LEU A  89
LEU A 123
LEU A 120
 None
 0.98A 1sqnB-4r6fA:
undetectable		 1sqnB-4r6fA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K

(synthetic
construct) 		PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 241
LEU A 217
LEU A 193
LEU A 227
LEU A 224
 None
 0.97A 1sqnB-4r6gA:
undetectable		 1sqnB-4r6gA:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 766
ASN A 770
GLN A 776
MET A 807
LEU A 848
LEU A 938
CYH A 942
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.4A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
 0.71A 1sqnB-4udbA:
35.1		 1sqnB-4udbA:
52.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 766
LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
MET A 852
LEU A 938
CYH A 942
 CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
 0.55A 1sqnB-4udbA:
35.1		 1sqnB-4udbA:
52.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 772
LEU A 769
LEU A 766
LEU A 814
MET A 852
LEU A 827
 CV7  A1987 ( 4.5A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.6A)
CV7  A1987 ( 4.0A)
CV7  A1987 ( 3.7A)
None
 1.27A 1sqnB-4udbA:
35.1		 1sqnB-4udbA:
52.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uip REPEBODY (RAC1)

(Listeria
monocytogenes;
Eptatretus
burgeri;
synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU B 163
LEU B 139
LEU B 115
LEU B 149
LEU B 146
 None
 1.05A 1sqnB-4uipB:
undetectable		 1sqnB-4uipB:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 230
LEU A 204
LEU A 180
LEU A 216
LEU A 211
 None
 1.13A 1sqnB-4v2eA:
undetectable		 1sqnB-4v2eA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5c LRRTM

(synthetic
construct) 		PF13855
(LRR_8) 		5 LEU A  83
LEU A  59
LEU A  35
LEU A  69
LEU A  66
 None
 1.07A 1sqnB-5a5cA:
undetectable		 1sqnB-5a5cA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5c LRRTM

(synthetic
construct) 		PF13855
(LRR_8) 		5 LEU A 107
LEU A  83
LEU A  59
LEU A  93
LEU A  90
 None
 1.02A 1sqnB-5a5cA:
undetectable		 1sqnB-5a5cA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5c LRRTM

(synthetic
construct) 		PF13855
(LRR_8) 		5 LEU A 131
LEU A 107
LEU A  83
LEU A 117
LEU A 114
 None
 1.07A 1sqnB-5a5cA:
undetectable		 1sqnB-5a5cA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5c LRRTM

(synthetic
construct) 		PF13855
(LRR_8) 		5 LEU A 155
LEU A 131
LEU A 107
LEU A 141
LEU A 138
 None
 1.07A 1sqnB-5a5cA:
undetectable		 1sqnB-5a5cA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5c LRRTM

(synthetic
construct) 		PF13855
(LRR_8) 		5 LEU A 251
LEU A 227
LEU A 203
LEU A 237
LEU A 234
 None
 1.01A 1sqnB-5a5cA:
undetectable		 1sqnB-5a5cA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		5 LEU A 140
LEU A 136
LEU A 133
LEU A  48
LEU A 105
 None
 1.11A 1sqnB-5dooA:
undetectable		 1sqnB-5dooA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Ureibacillus
thermosphaericus) 		PF01113
(DapB_N)
PF16654
(DAPDH_C) 		5 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 1.05A 1sqnB-5gz1A:
undetectable		 1sqnB-5gz1A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iyx SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU C  76
LEU C 100
LEU C 124
LEU C  33
LEU C  92
 None
 1.14A 1sqnB-5iyxC:
undetectable		 1sqnB-5iyxC:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		5 LEU A 184
LEU A 187
LEU A 190
MET A 197
LEU A 119
 None
 1.02A 1sqnB-5lq4A:
undetectable		 1sqnB-5lq4A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m30 TYPE VI SECRETION
PROTEIN

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		5 LEU A 303
LEU A 306
ASN A 307
LEU A 309
LEU A 250
 None
 1.15A 1sqnB-5m30A:
undetectable		 1sqnB-5m30A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwn TYPE VI SECRETION
PROTEIN

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		5 LEU A 303
LEU A 306
ASN A 307
LEU A 309
LEU A 250
 None
 1.12A 1sqnB-5mwnA:
undetectable		 1sqnB-5mwnA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 LEU A 766
ASN A 770
GLN A 776
MET A 807
LEU A 848
LEU A 938
CYH A 942
 ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
None
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
 0.85A 1sqnB-5mwpA:
36.8		 1sqnB-5mwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 8 LEU A 766
LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
LEU A 938
CYH A 942
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
 0.41A 1sqnB-5mwpA:
36.8		 1sqnB-5mwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 772
LEU A 769
LEU A 766
LEU A 814
LEU A 827
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-4.1A)
None
 1.13A 1sqnB-5mwpA:
36.8		 1sqnB-5mwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj8 KINESIN LIGHT CHAIN
1

(Homo sapiens) 		no annotation 5 LEU A 213
LEU A 216
LEU A 219
LEU A 240
LEU A 261
 None
 0.90A 1sqnB-5oj8A:
undetectable		 1sqnB-5oj8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
LEU A 562
GLN A 566
MET A 597
MET A 642
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
 0.78A 1sqnB-5uc1A:
24.8		 1sqnB-5uc1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
LEU A 562
GLN A 566
MET A 597
MET A 600
MET A 642
 486  A 801 (-4.7A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
None
486  A 801 ( 3.8A)
 0.83A 1sqnB-5uc1A:
24.8		 1sqnB-5uc1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 LEU A 562
LEU A 559
LEU A 604
MET A 642
LEU A 617
 486  A 801 ( 4.8A)
486  A 801 (-4.7A)
486  A 801 ( 3.8A)
486  A 801 ( 3.8A)
None
 0.99A 1sqnB-5uc1A:
24.8		 1sqnB-5uc1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 LEU A 562
MET A 635
LEU A 604
MET A 642
LEU A 617
 486  A 801 ( 4.8A)
486  A 801 ( 4.7A)
486  A 801 ( 3.8A)
486  A 801 ( 3.8A)
None
 0.85A 1sqnB-5uc1A:
24.8		 1sqnB-5uc1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf1 O13

(Petromyzon
marinus) 		no annotation 5 LEU B 126
LEU B 102
LEU B  78
LEU B 112
LEU B 109
 None
 1.04A 1sqnB-5uf1B:
undetectable		 1sqnB-5uf1B:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufb TN4-22

(Petromyzon
marinus) 		no annotation 5 LEU A 109
LEU A  85
LEU A  61
LEU A  95
LEU A  92
 None
 1.06A 1sqnB-5ufbA:
undetectable		 1sqnB-5ufbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufb TN4-22

(Petromyzon
marinus) 		no annotation 5 LEU A 133
LEU A 109
LEU A  85
LEU A 119
LEU A 116
 None
 1.09A 1sqnB-5ufbA:
undetectable		 1sqnB-5ufbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uff RBC36

(Petromyzon
marinus) 		no annotation 5 LEU A 102
LEU A  78
LEU A  54
LEU A  88
LEU A  85
 None
 1.06A 1sqnB-5uffA:
undetectable		 1sqnB-5uffA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A 115
LEU A 201
CYH A 205
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 2.8A)
1TA  A 301 ( 3.8A)
1TA  A 301 (-3.6A)
 0.52A 1sqnB-5ufsA:
37.1		 1sqnB-5ufsA:
56.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 LEU A  32
LEU A  35
GLN A  39
MET A  70
MET A  73
MET A 115
LEU A 201
 1TA  A 301 (-3.5A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 ( 2.8A)
1TA  A 301 ( 3.8A)
 0.86A 1sqnB-5ufsA:
37.1		 1sqnB-5ufsA:
56.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
MET A 108
LEU A  77
MET A 115
LEU A  90
 1TA  A 301 ( 3.6A)
1TA  A 301 ( 3.0A)
1TA  A 301 ( 3.4A)
1TA  A 301 ( 2.8A)
None
 0.89A 1sqnB-5ufsA:
37.1		 1sqnB-5ufsA:
56.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk4 VARIABLE LYMPHOCYTE
RECEPTOR 39

(Petromyzon
marinus) 		no annotation 5 LEU D 102
LEU D  78
LEU D  54
LEU D  88
LEU D  85
 None
 1.00A 1sqnB-5wk4D:
undetectable		 1sqnB-5wk4D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 5 LEU A  64
LEU A  67
LEU A  70
LEU A  98
TYR A 101
 None
 1.14A 1sqnB-5yfbA:
undetectable		 1sqnB-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2

(Petromyzon
marinus) 		no annotation 5 LEU C 102
LEU C  78
LEU C  54
LEU C  88
LEU C  85
 None
 1.06A 1sqnB-6bxaC:
undetectable		 1sqnB-6bxaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxe VARIABLE LYMPHOCYTE
RECEPTOR DIVERSITY
REGION

(Petromyzon
marinus) 		no annotation 5 LEU A 102
LEU A  78
LEU A  54
LEU A  88
LEU A  85
 None
 0.94A 1sqnB-6bxeA:
undetectable		 1sqnB-6bxeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 5 LEU A 225
LEU A 216
GLN A 417
LEU A 211
LEU A 208
 None
 1.13A 1sqnB-6es9A:
3.1		 1sqnB-6es9A:
undetectable