SIMILAR PATTERNS OF AMINO ACIDS FOR 1SQN_A_NDRA1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c20 DEAD RINGER PROTEIN

(Drosophila
melanogaster) 		PF01388
(ARID) 		5 LEU A  59
LEU A  56
LEU A  16
GLN A  15
MET A  49
 None
 1.48A 1sqnA-1c20A:
undetectable		 1sqnA-1c20A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ

(Sinorhizobium
meliloti) 		PF00072
(Response_reg) 		5 LEU A  72
LEU A  69
ASN A  68
LEU A  66
MET A  60
 None
 1.31A 1sqnA-1dbwA:
undetectable		 1sqnA-1dbwA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 LEU A1123
LEU A1274
LEU A1150
MET A1154
TYR A1146
 None
GOL  A2574 (-4.2A)
None
None
None
 1.32A 1sqnA-1e6yA:
undetectable		 1sqnA-1e6yA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouo NUCLEASE

(Vibrio
vulnificus) 		PF04231
(Endonuclease_1) 		5 LEU A 119
ASN A 118
LEU A 116
GLN A 217
MET A 177
 None
 1.39A 1sqnA-1ouoA:
undetectable		 1sqnA-1ouoA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 LEU A 242
LEU A 161
GLN A 172
LEU A 361
MET A 365
 HEM  A1430 ( 4.5A)
None
None
HEM  A1430 ( 4.9A)
None
 1.32A 1sqnA-1uedA:
2.5		 1sqnA-1uedA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 496
LEU A 493
LEU A 490
LEU A 379
MET A 433
 None
 1.39A 1sqnA-1uhlA:
23.5		 1sqnA-1uhlA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 251
LEU A 281
LEU A 310
LEU A 276
MET A 302
 None
 1.44A 1sqnA-1yrgA:
undetectable		 1sqnA-1yrgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		5 LEU U 460
LEU U 457
LEU U 454
LEU U 343
MET U 397
 None
 1.43A 1sqnA-1z5xU:
14.9		 1sqnA-1z5xU:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		5 LEU A 127
LEU A  83
LEU A  84
GLN A 155
TYR A  24
 None
 1.36A 1sqnA-1zswA:
undetectable		 1sqnA-1zswA:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 701
LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 742
MET A 745
 None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
 0.59A 1sqnA-2ax9A:
34.4		 1sqnA-2ax9A:
53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 701
LEU A 704
ASN A 705
LEU A 707
LEU A 873
 None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-4.4A)
 1.44A 1sqnA-2ax9A:
34.4		 1sqnA-2ax9A:
53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 701
LEU A 704
LEU A 707
GLN A 711
MET A 742
MET A 745
MET A 787
 None
BHM  A   1 (-4.0A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
 0.75A 1sqnA-2ax9A:
34.4		 1sqnA-2ax9A:
53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 707
GLN A 711
MET A 742
MET A 745
MET A 895
 BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
None
 1.08A 1sqnA-2ax9A:
34.4		 1sqnA-2ax9A:
53.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chq REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 LEU A 289
MET A 254
MET A 259
LEU A 296
MET A 231
 None
 1.39A 1sqnA-2chqA:
undetectable		 1sqnA-2chqA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 LEU A 267
LEU A 260
GLN A 179
MET A 190
MET A 166
 None
 1.34A 1sqnA-2fafA:
undetectable		 1sqnA-2fafA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7e ENDONUCLEASE I

(Vibrio cholerae) 		PF04231
(Endonuclease_1) 		5 LEU A 119
ASN A 118
LEU A 116
GLN A 217
MET A 177
 None
 1.35A 1sqnA-2g7eA:
undetectable		 1sqnA-2g7eA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 265
LEU A 268
LEU A 271
MET A 306
LEU A 345
 None
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.9A)
OHT  A 500 (-4.3A)
 0.40A 1sqnA-2gpvA:
25.5		 1sqnA-2gpvA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in5 HYPOTHETICAL
LIPOPROTEIN YMCC

(Escherichia
coli) 		PF11102
(YjbF) 		5 LEU A 183
LEU A  76
LEU A  77
LEU A  39
MET A  37
 None
 1.41A 1sqnA-2in5A:
undetectable		 1sqnA-2in5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 LEU A  82
LEU A  85
GLN A 133
LEU A 186
MET A 163
 None
 1.39A 1sqnA-2nx4A:
undetectable		 1sqnA-2nx4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pu3 ENDONUCLEASE I

(Aliivibrio
salmonicida) 		PF04231
(Endonuclease_1) 		5 LEU A 119
ASN A 118
LEU A 116
GLN A 217
MET A 177
 None
 1.34A 1sqnA-2pu3A:
undetectable		 1sqnA-2pu3A:
19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  29
ASN A  33
MET A  70
LEU A 111
CYH A 205
 1CA  A 247 ( 3.6A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 3.8A)
None
1CA  A 247 (-4.0A)
 0.80A 1sqnA-2q3yA:
37.3		 1sqnA-2q3yA:
62.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		9 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
MET A 115
CYH A 205
 1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.7A)
1CA  A 247 (-4.0A)
 0.39A 1sqnA-2q3yA:
37.3		 1sqnA-2q3yA:
62.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
LEU A  32
LEU A  29
LEU A  77
MET A 115
 1CA  A 247 ( 4.4A)
1CA  A 247 (-4.0A)
1CA  A 247 ( 3.6A)
1CA  A 247 ( 3.9A)
1CA  A 247 ( 3.7A)
 1.22A 1sqnA-2q3yA:
37.3		 1sqnA-2q3yA:
62.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjx PROTEIN BIM1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  13
LEU A  16
ASN A  17
LEU A  20
GLN A  38
 None
 1.41A 1sqnA-2qjxA:
undetectable		 1sqnA-2qjxA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlv NUCLEAR PROTEIN SNF4

(Saccharomyces
cerevisiae) 		PF00571
(CBS) 		5 LEU C 318
LEU C 314
LEU C 310
LEU C 132
MET C 284
 None
 1.35A 1sqnA-2qlvC:
undetectable		 1sqnA-2qlvC:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		5 LEU A 163
LEU A 164
LEU A  80
MET A  76
TYR A 142
 None
 1.26A 1sqnA-2raeA:
undetectable		 1sqnA-2raeA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 401
LEU A 421
LEU A 419
MET A 414
LEU A 427
 None
 1.49A 1sqnA-2z63A:
undetectable		 1sqnA-2z63A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 401
LEU A 421
LEU A 419
MET A 414
LEU A 427
 None
 1.48A 1sqnA-2z66A:
undetectable		 1sqnA-2z66A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1e BETAC-S LYASE

(Streptococcus
anginosus) 		PF00155
(Aminotran_1_2) 		5 LEU A 229
LEU A 227
LEU A 253
GLN A 256
LEU A 165
 None
 1.50A 1sqnA-3b1eA:
undetectable		 1sqnA-3b1eA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7a UPF0201 PROTEIN
PH1010

(Pyrococcus
horikoshii) 		PF01877
(RNA_binding) 		5 LEU A  57
LEU A  60
LEU A  63
GLN A  67
LEU A  77
 None
 1.18A 1sqnA-3d7aA:
undetectable		 1sqnA-3d7aA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2

(Actinoplanes
teichomyceticus) 		PF02585
(PIG-L) 		5 LEU A  10
LEU A  28
LEU A  86
GLN A 221
MET A 218
 None
 1.39A 1sqnA-3dffA:
undetectable		 1sqnA-3dffA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A

(Homo sapiens) 		PF00620
(RhoGAP) 		5 LEU A  15
LEU A  12
LEU A   9
LEU A 137
CYH A 161
 None
 1.18A 1sqnA-3eapA:
undetectable		 1sqnA-3eapA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv1 POLAR AMINO ACID ABC
UPTAKE TRANSPORTER
SUBSTRATE BINDING
PROTEIN

(Streptococcus
thermophilus) 		PF00497
(SBP_bac_3) 		5 LEU A 202
LEU A 203
LEU A 213
TYR A 222
MET A 148
 None
 1.27A 1sqnA-3hv1A:
undetectable		 1sqnA-3hv1A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilk UNCHARACTERIZED
TRNA/RRNA
METHYLTRANSFERASE
HI0380

(Haemophilus
influenzae) 		PF00588
(SpoU_methylase) 		5 LEU A 223
LEU A 227
ASN A 224
MET A 203
TYR A 210
 None
 1.34A 1sqnA-3ilkA:
undetectable		 1sqnA-3ilkA:
22.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 715
LEU A 718
ASN A 719
LEU A 721
GLN A 725
MET A 756
MET A 759
MET A 801
CYH A 891
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
 0.56A 1sqnA-3kbaA:
41.7		 1sqnA-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 715
LEU A 718
ASN A 719
LEU A 721
MET A 756
MET A 759
MET A 801
TYR A 890
CYH A 891
MET A 909
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 (-3.5A)
None
 0.59A 1sqnA-3kbaA:
41.7		 1sqnA-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 715
MET A 756
LEU A 797
TYR A 890
CYH A 891
 WOW  A   1 (-3.9A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-3.5A)
 0.98A 1sqnA-3kbaA:
41.7		 1sqnA-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 721
LEU A 718
LEU A 715
LEU A 763
MET A 801
 WOW  A   1 ( 4.3A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-4.2A)
 1.19A 1sqnA-3kbaA:
41.7		 1sqnA-3kbaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 676
LEU A 667
LEU A 668
LEU A 687
MET A 525
 None
 1.30A 1sqnA-3kn5A:
undetectable		 1sqnA-3kn5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Toxoplasma
gondii) 		PF00490
(ALAD) 		5 LEU A 172
LEU A 115
LEU A 114
MET A  72
LEU A 131
 None
 1.49A 1sqnA-3obkA:
undetectable		 1sqnA-3obkA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 LEU A 381
LEU A 378
LEU A 375
LEU A 348
MET A 352
 None
 1.44A 1sqnA-3rx8A:
undetectable		 1sqnA-3rx8A:
18.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 LEU A  29
ASN A  33
MET A  70
LEU A 111
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
None
1CA  A 249 (-4.0A)
 0.84A 1sqnA-3ry9A:
36.4		 1sqnA-3ry9A:
61.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		9 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
MET A 115
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
 0.47A 1sqnA-3ry9A:
36.4		 1sqnA-3ry9A:
61.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 LEU A  35
LEU A  32
LEU A  29
LEU A  77
MET A 115
 1CA  A 249 ( 4.4A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
 1.28A 1sqnA-3ry9A:
36.4		 1sqnA-3ry9A:
61.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
INHIBITOR

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU E 224
LEU E 253
LEU E 281
LEU E 229
CYH E 215
 None
 1.49A 1sqnA-3tsrE:
undetectable		 1sqnA-3tsrE:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgo MESO-DIAMINOPIMELATE
DEHYDROGENASE

(Clostridium
tetani) 		PF16654
(DAPDH_C) 		5 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 0.99A 1sqnA-3wgoA:
undetectable		 1sqnA-3wgoA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxf UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF00443
(UCH) 		5 LEU A 697
LEU A 695
LEU A 694
MET A 789
LEU A 729
 None
 1.19A 1sqnA-3wxfA:
undetectable		 1sqnA-3wxfA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am9 CHAPERONE SYCD

(Yersinia
enterocolitica) 		PF07720
(TPR_3) 		5 LEU A  36
LEU A  39
LEU A  42
GLN A  46
CYH A  63
 None
 0.71A 1sqnA-4am9A:
undetectable		 1sqnA-4am9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 166
ASN A 113
LEU A 167
LEU A 144
MET A 255
 None
 1.25A 1sqnA-4b99A:
undetectable		 1sqnA-4b99A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsn EXPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 LEU A 351
LEU A 347
LEU A 343
TYR A 372
MET A 291
 None
 1.27A 1sqnA-4bsnA:
undetectable		 1sqnA-4bsnA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 129
ASN A  75
LEU A 130
LEU A 105
MET A 212
 None
 1.29A 1sqnA-4ez5A:
undetectable		 1sqnA-4ez5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 780
LEU A 776
LEU A 754
MET A 716
MET A 748
 None
 1.49A 1sqnA-4feqA:
undetectable		 1sqnA-4feqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes) 		PF02016
(Peptidase_S66) 		5 LEU A 205
LEU A 208
ASN A 209
LEU A 211
LEU A 225
 None
 1.06A 1sqnA-4injA:
undetectable		 1sqnA-4injA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip3 ORF169B

(Shigella
flexneri) 		no annotation 5 LEU A  28
LEU A  31
ASN A  32
LEU A  36
LEU A 159
 None
 1.45A 1sqnA-4ip3A:
undetectable		 1sqnA-4ip3A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j25 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
putida) 		PF13640
(2OG-FeII_Oxy_3) 		5 LEU A 140
LEU A 142
LEU A 193
LEU A  33
CYH A  83
 None
 1.41A 1sqnA-4j25A:
undetectable		 1sqnA-4j25A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lws UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN

(Thermomonospora
curvata;
Thermomonospora
curvata) 		PF06013
(WXG100)
PF06013
(WXG100) 		5 LEU B  33
LEU B  30
LEU B  27
MET B  66
MET A  29
 None
 1.48A 1sqnA-4lwsB:
undetectable		 1sqnA-4lwsB:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 445
LEU A 480
LEU A 504
LEU A 475
MET A 496
 None
 1.43A 1sqnA-4lxrA:
undetectable		 1sqnA-4lxrA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 714
LEU A 738
ASN A 736
LEU A 762
MET A 722
 None
 1.45A 1sqnA-4m7eA:
undetectable		 1sqnA-4m7eA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE

(Geobacillus
stearothermophilus) 		PF16499
(Melibiase_2) 		5 LEU A 342
LEU A 345
MET A  27
LEU A 334
TYR A  50
 None
 1.12A 1sqnA-4nxkA:
undetectable		 1sqnA-4nxkA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens) 		PF08389
(Xpo1) 		5 LEU B   8
LEU B  50
LEU B  51
MET B  67
LEU B  37
 None
 1.36A 1sqnA-4ol0B:
undetectable		 1sqnA-4ol0B:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4our PHYTOCHROME B

(Arabidopsis
thaliana) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 LEU B 205
LEU B 187
ASN B 188
LEU B 186
LEU B 174
 None
 1.29A 1sqnA-4ourB:
undetectable		 1sqnA-4ourB:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 564
GLN A 570
MET A 601
MET A 646
TYR A 735
CYH A 736
 MOF  A 801 (-3.0A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-4.8A)
MOF  A 801 (-3.7A)
 0.67A 1sqnA-4p6wA:
35.8		 1sqnA-4p6wA:
54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
MET A 604
MET A 646
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.4A)
 0.90A 1sqnA-4p6wA:
35.8		 1sqnA-4p6wA:
54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
MET A 646
CYH A 736
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
 0.66A 1sqnA-4p6wA:
35.8		 1sqnA-4p6wA:
54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 566
LEU A 563
MET A 639
LEU A 608
MET A 646
 MOF  A 801 ( 4.6A)
MOF  A 801 (-3.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.4A)
 1.31A 1sqnA-4p6wA:
35.8		 1sqnA-4p6wA:
54.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A  83
LEU A 108
LEU A 132
LEU A 100
CYH A  80
 None
 1.29A 1sqnA-4qdhA:
undetectable		 1sqnA-4qdhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 113
LEU A 132
ASN A 135
LEU A 162
LEU A 106
 None
 1.45A 1sqnA-4qdhA:
undetectable		 1sqnA-4qdhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A 159
LEU A 160
LEU A 162
GLN A 128
LEU A 117
 None
 1.43A 1sqnA-4roeA:
undetectable		 1sqnA-4roeA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1a ENOYL-COA DELTA
ISOMERASE 2

(Homo sapiens) 		PF00378
(ECH_1) 		5 LEU A 188
LEU A 189
ASN A 185
LEU A 336
GLN A 242
 CL  A 401 ( 4.9A)
CL  A 401 ( 4.4A)
CL  A 401 ( 4.2A)
None
None
 1.29A 1sqnA-4u1aA:
undetectable		 1sqnA-4u1aA:
19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 766
ASN A 770
MET A 807
LEU A 848
CYH A 942
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.4A)
CV7  A1987 (-4.0A)
 0.76A 1sqnA-4udbA:
35.8		 1sqnA-4udbA:
52.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 766
LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
MET A 852
CYH A 942
 CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
 0.49A 1sqnA-4udbA:
35.8		 1sqnA-4udbA:
52.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 772
LEU A 769
LEU A 766
LEU A 814
MET A 852
 CV7  A1987 ( 4.5A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.6A)
CV7  A1987 ( 4.0A)
CV7  A1987 ( 3.7A)
 1.29A 1sqnA-4udbA:
35.8		 1sqnA-4udbA:
52.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		5 LEU A 335
LEU A 329
GLN A 326
LEU A 258
MET A 260
 None
 1.25A 1sqnA-4y6oA:
undetectable		 1sqnA-4y6oA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF13855
(LRR_8) 		5 LEU B 211
LEU B 232
ASN B 235
GLN B 255
LEU B 204
 None
 1.40A 1sqnA-4yebB:
undetectable		 1sqnA-4yebB:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7o PROLIFERATING CELL
NUCLEAR ANTIGEN

(Leishmania
donovani) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A  72
LEU A  70
ASN A  71
LEU A 118
LEU A  79
 None
 1.42A 1sqnA-5b7oA:
undetectable		 1sqnA-5b7oA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN

(Leishmania
donovani) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A  72
LEU A  70
ASN A  71
LEU A 118
LEU A  79
 None
 1.40A 1sqnA-5cfkA:
undetectable		 1sqnA-5cfkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqr ELONGATOR COMPLEX
PROTEIN 1

(Homo sapiens) 		PF04762
(IKI3) 		5 LEU A 918
LEU A 921
ASN A 922
LEU A 924
GLN A 932
 None
 0.94A 1sqnA-5cqrA:
undetectable		 1sqnA-5cqrA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 LEU A 526
LEU A 520
GLN A 490
LEU A 426
MET A 462
 None
 1.46A 1sqnA-5dotA:
undetectable		 1sqnA-5dotA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 179
LEU A 155
ASN A 182
LEU A 139
LEU A 168
 None
 1.48A 1sqnA-5gmhA:
undetectable		 1sqnA-5gmhA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwp ABA RECEPTOR RCAR3

(Oryza sativa) 		PF10604
(Polyketide_cyc2) 		5 LEU C 179
LEU C 178
ASN C 182
LEU C 132
TYR C 135
 None
A8S  C 301 (-4.2A)
A8S  C 301 (-3.7A)
None
A8S  C 301 ( 4.8A)
 1.39A 1sqnA-5gwpC:
undetectable		 1sqnA-5gwpC:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Ureibacillus
thermosphaericus) 		PF01113
(DapB_N)
PF16654
(DAPDH_C) 		5 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 1.07A 1sqnA-5gz1A:
undetectable		 1sqnA-5gz1A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A 253
LEU A 294
LEU A 318
LEU A 289
MET A 310
 None
 1.45A 1sqnA-5hdhA:
undetectable		 1sqnA-5hdhA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A 542
LEU A 561
ASN A 564
LEU A 591
LEU A 535
 None
 1.41A 1sqnA-5hdhA:
undetectable		 1sqnA-5hdhA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3e PUTATIVE
DEOXYRIBONUCLEASE-2

(Burkholderia
thailandensis) 		PF03265
(DNase_II) 		5 LEU A  15
LEU A 142
LEU A 118
LEU A 317
TYR A  41
 None
None
EDO  A 400 (-4.3A)
None
None
 0.94A 1sqnA-5i3eA:
undetectable		 1sqnA-5i3eA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Mycobacterium
tuberculosis) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 LEU A 233
LEU A 226
MET A 159
MET A 156
MET A 132
 None
 1.44A 1sqnA-5i67A:
undetectable		 1sqnA-5i67A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m30 TYPE VI SECRETION
PROTEIN

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		5 LEU A 303
LEU A 306
ASN A 307
LEU A 309
LEU A 250
 None
 1.01A 1sqnA-5m30A:
undetectable		 1sqnA-5m30A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwn TYPE VI SECRETION
PROTEIN

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		5 LEU A 303
LEU A 306
ASN A 307
LEU A 309
LEU A 250
 None
 0.99A 1sqnA-5mwnA:
undetectable		 1sqnA-5mwnA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 766
ASN A 770
MET A 807
LEU A 848
CYH A 942
 ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
ECV  A1101 (-3.6A)
None
ECV  A1101 (-4.0A)
 0.93A 1sqnA-5mwpA:
36.2		 1sqnA-5mwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 LEU A 766
LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
CYH A 942
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
 0.48A 1sqnA-5mwpA:
36.2		 1sqnA-5mwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 LEU A 559
ASN A 560
LEU A 562
GLN A 566
MET A 597
MET A 600
MET A 642
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
None
486  A 801 ( 3.8A)
 0.87A 1sqnA-5uc1A:
24.6		 1sqnA-5uc1A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
MET A 115
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 ( 2.8A)
 0.80A 1sqnA-5ufsA:
37.2		 1sqnA-5ufsA:
56.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A 115
CYH A 205
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.6A)
 0.48A 1sqnA-5ufsA:
37.2		 1sqnA-5ufsA:
56.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8c TRANSCRIPTIONAL
REGULATOR

(Actinomyces
oris) 		no annotation 5 LEU A 134
LEU A 101
LEU A 189
MET A  88
TYR A 360
 None
 1.43A 1sqnA-5v8cA:
undetectable		 1sqnA-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq5 OSTEOMODULIN

(Homo sapiens) 		no annotation 5 LEU A 169
LEU A 193
LEU A 219
LEU A 188
MET A 211
 None
 1.48A 1sqnA-5yq5A:
undetectable		 1sqnA-5yq5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 LEU A  70
LEU A  94
LEU A 130
LEU A  89
MET A 122
 None
 1.48A 1sqnA-5zlnA:
undetectable		 1sqnA-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6el8 FORKHEAD BOX PROTEIN
N1

(Homo sapiens) 		no annotation 5 LEU A 322
ASN A 321
LEU A 278
MET A 354
CYH A 327
 None
 1.27A 1sqnA-6el8A:
undetectable		 1sqnA-6el8A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 5 LEU A 252
LEU A 253
LEU A 373
GLN A 378
LEU A 364
 None
 1.34A 1sqnA-6fshA:
2.3		 1sqnA-6fshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 5 LEU A 551
LEU A 501
ASN A 504
LEU A 502
LEU A 454
 None
 1.41A 1sqnA-6gh2A:
undetectable		 1sqnA-6gh2A:
undetectable