SIMILAR PATTERNS OF AMINO ACIDS FOR 1SQF_A_SAMA430

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cx1 ENDOGLUCANASE C

(Cellulomonas
fimi) 		PF02018
(CBM_4_9) 		5 ALA A 136
GLY A  44
GLY A  43
GLY A  98
PRO A  79
 None
 1.04A 1sqfA-1cx1A:
undetectable		 1sqfA-1cx1A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dct PROTEIN
(MODIFICATION
METHYLASE HAEIII)

(Haemophilus
influenzae) 		PF00145
(DNA_methylase) 		5 GLY A  11
GLY A  12
ASP A  31
ASP A  50
PRO A  70
 None
 0.55A 1sqfA-1dctA:
9.5		 1sqfA-1dctA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elj MALTODEXTRIN-BINDING
PROTEIN

(Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		5 ALA A 351
GLY A 347
GLY A 346
ILE A 364
GLY A 192
 None
 1.04A 1sqfA-1eljA:
undetectable		 1sqfA-1eljA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		6 ALA A  49
GLY A  51
ILE A  72
ASP A  73
ASP A  89
PRO A 107
 NEA  A 500 ( 3.7A)
None
NEA  A 500 (-3.8A)
None
NEA  A 500 (-3.4A)
NEA  A 500 (-3.8A)
 0.82A 1sqfA-1g38A:
11.1		 1sqfA-1g38A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 ALA A 367
GLY A   9
ASP A 349
GLY A 348
ARG A 346
 None
 0.75A 1sqfA-1gsoA:
3.8		 1sqfA-1gsoA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 CYH A  13
ALA A 145
GLY A 148
GLY A 149
GLY A  88
 None
 0.82A 1sqfA-1h74A:
undetectable		 1sqfA-1h74A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR

(Homo sapiens) 		PF00079
(Serpin) 		5 GLY A 195
LYS A 194
ASP A 394
GLY A 397
ARG A 396
 None
 1.03A 1sqfA-1imvA:
undetectable		 1sqfA-1imvA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy9 SPERMIDINE SYNTHASE

(Bacillus
subtilis) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		6 GLY A  88
GLY A  89
ILE A 108
ASP A 109
ASP A 138
GLY A 139
 None
 0.64A 1sqfA-1iy9A:
8.3		 1sqfA-1iy9A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 ALA A 416
GLY A 451
GLY A 368
ARG A 367
PRO A 409
 None
 0.97A 1sqfA-1j0hA:
undetectable		 1sqfA-1j0hA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		6 GLY A  86
GLY A  87
ILE A 105
ASP A 106
ASP A 141
GLY A 142
 None
 0.45A 1sqfA-1mjfA:
5.9		 1sqfA-1mjfA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 ALA A 707
GLY A 705
GLY A 704
LYS A 703
GLY A 716
 None
 0.97A 1sqfA-1n7fA:
undetectable		 1sqfA-1n7fA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qib 72 KDA TYPE IV
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 ALA A 167
GLY A 176
GLY A 175
ASP A 181
GLY A 147
 None
CA  A 504 ( 4.6A)
CA  A 504 (-4.6A)
CA  A 503 (-3.6A)
None
 1.05A 1sqfA-1qibA:
undetectable		 1sqfA-1qibA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ALA A  16
GLY A  14
GLY A  13
GLY A 374
ARG A 376
 FAD  A1656 (-3.4A)
FAD  A1656 (-3.5A)
FAD  A1656 (-3.4A)
CA  A1658 ( 4.1A)
None
 0.96A 1sqfA-1qlbA:
undetectable		 1sqfA-1qlbA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 GLY A 263
GLY A 262
ILE A 267
ASP A 266
GLY A 292
 None
 0.98A 1sqfA-1ryyA:
undetectable		 1sqfA-1ryyA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		8 CYH A 254
ALA A 256
GLY A 258
GLY A 259
ASP A 303
GLY A 304
ARG A 305
PRO A 324
 None
 0.59A 1sqfA-1sqgA:
61.3		 1sqfA-1sqgA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1va8 MAGUK P55 SUBFAMILY
MEMBER 5

(Mus musculus) 		PF00595
(PDZ) 		5 ALA A  61
GLY A  59
GLY A  58
LYS A  57
GLY A  70
 None
 1.05A 1sqfA-1va8A:
undetectable		 1sqfA-1va8A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		5 GLY A  50
GLY A  51
ILE A  68
ASP A  93
ARG A  95
 None
None
SAM  A 302 (-3.7A)
SAM  A 302 (-3.4A)
None
 0.45A 1sqfA-1ve3A:
12.8		 1sqfA-1ve3A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlh GELATION FACTOR

(Dictyostelium
discoideum) 		PF00630
(Filamin) 		5 ALA A 670
GLY A 660
GLY A 658
ASP A 720
GLY A 750
 None
 1.02A 1sqfA-1wlhA:
undetectable		 1sqfA-1wlhA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xj5 SPERMIDINE SYNTHASE
1

(Arabidopsis
thaliana) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		6 GLY A 132
GLY A 133
ILE A 152
ASP A 153
ASP A 182
GLY A 183
 None
 0.55A 1sqfA-1xj5A:
10.2		 1sqfA-1xj5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		5 GLY A  84
GLY A  87
ASP A  78
ASP A  74
GLY A  73
 None
 1.04A 1sqfA-1y3nA:
undetectable		 1sqfA-1y3nA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2c SPERMIDINE SYNTHASE

(Caenorhabditis
elegans) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 120
GLY A 121
ILE A 140
ASP A 141
GLY A 171
 None
 0.69A 1sqfA-2b2cA:
9.2		 1sqfA-2b2cA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		6 CYH A 234
ALA A 236
GLY A 238
LYS A 240
ASP A 260
ASP A 285
 SAM  A1201 (-3.8A)
SAM  A1201 (-4.1A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
None
SAM  A1201 (-3.6A)
 0.78A 1sqfA-2b9eA:
26.7		 1sqfA-2b9eA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		5 GLY A 351
GLY A 352
ASP A 122
ASP A 117
GLY A 298
 None
 1.05A 1sqfA-2dw6A:
undetectable		 1sqfA-2dw6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		5 ALA A 127
GLY A 129
GLY A 177
ARG A 178
PRO A 196
 None
 0.90A 1sqfA-2frxA:
32.3		 1sqfA-2frxA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hal HEPATITIS A PROTEASE
3C

(Hepatovirus A) 		PF00548
(Peptidase_C3) 		5 ALA A 193
GLY A 194
GLY A 195
ASP A  84
ASP A 158
 None
 0.96A 1sqfA-2halA:
undetectable		 1sqfA-2halA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		6 ALA A  19
GLY A  22
GLY A  23
ILE A  61
ASP A 103
PRO A  80
 None
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
None
SAH  A 328 (-4.0A)
 1.21A 1sqfA-2i9kA:
9.0		 1sqfA-2i9kA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		5 GLY A  22
GLY A  23
ASP A  42
ASP A  60
PRO A  80
 None
SAH  A 328 (-3.6A)
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
 0.59A 1sqfA-2i9kA:
9.0		 1sqfA-2i9kA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 ALA A 223
GLY A 222
GLY A 220
GLY A 203
PRO A 180
 None
 0.98A 1sqfA-2jg5A:
3.1		 1sqfA-2jg5A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A 298
GLY A 296
GLY A 293
ILE A 377
GLY A 379
 None
 0.96A 1sqfA-2jifA:
undetectable		 1sqfA-2jifA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		5 ALA A 525
GLY A 526
GLY A 527
ASP A 518
GLY A 368
 None
 0.92A 1sqfA-2nlzA:
undetectable		 1sqfA-2nlzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 GLY A 141
GLY A  30
ASP A 381
GLY A 378
PRO A  82
 GLY  A 141 ( 0.0A)
GLY  A  30 ( 0.0A)
ASP  A 381 ( 0.6A)
GLY  A 378 ( 0.0A)
PRO  A  82 ( 1.1A)
 0.96A 1sqfA-2nvvA:
undetectable		 1sqfA-2nvvA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 128
GLY A 129
ILE A 148
ASP A 149
ASP A 178
 None
None
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
 0.40A 1sqfA-2pt6A:
9.9		 1sqfA-2pt6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzf CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Homo sapiens) 		PF00005
(ABC_tran) 		5 GLY A 545
GLY A 544
ILE A 530
ASP A 529
ARG A 518
 None
 1.03A 1sqfA-2pzfA:
undetectable		 1sqfA-2pzfA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ALA A 212
GLY A 216
GLY A 217
ASP A 208
ASP A 204
 None
 0.95A 1sqfA-2wdwA:
undetectable		 1sqfA-2wdwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts CYTOCHROME

(Paracoccus
pantotrophus) 		PF13442
(Cytochrome_CBB3) 		6 ALA B  71
GLY B  75
GLY B  80
ASP B  68
ASP B 133
PRO B 122
 None
None
None
None
None
HEC  B 500 (-3.7A)
 1.27A 1sqfA-2xtsB:
undetectable		 1sqfA-2xtsB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		5 ALA A 132
GLY A 135
ASP A  85
GLY A 114
PRO A  35
 None
None
None
None
HEM  A 350 (-4.2A)
 0.97A 1sqfA-2yp1A:
undetectable		 1sqfA-2yp1A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		8 ALA A 269
GLY A 271
GLY A 272
LYS A 273
ASP A 293
ASP A 318
ARG A 320
PRO A 339
 SFG  A5748 (-4.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-3.7A)
SFG  A5748 (-4.5A)
SFG  A5748 (-4.0A)
 0.72A 1sqfA-2yxlA:
40.8		 1sqfA-2yxlA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb4 PROSTAGLANDIN
REDUCTASE 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 ALA A 163
GLY A 165
GLY A 339
ILE A 206
ASP A 211
 None
NAP  A 500 (-3.2A)
None
None
None
 0.95A 1sqfA-2zb4A:
7.5		 1sqfA-2zb4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		6 GLY A  88
GLY A  89
ILE A 108
ASP A 109
ASP A 144
GLY A 145
 None
 0.49A 1sqfA-2zsuA:
10.2		 1sqfA-2zsuA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		8 CYH A  91
ALA A  93
GLY A  95
GLY A  96
LYS A  97
ILE A 116
ARG A 144
PRO A 165
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
None
SFG  A 500 (-3.9A)
 0.58A 1sqfA-3a4tA:
28.8		 1sqfA-3a4tA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		8 CYH A  91
ALA A  93
GLY A  95
GLY A  96
LYS A  97
ILE A 116
ASP A 142
ARG A 144
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-4.0A)
None
 0.58A 1sqfA-3a4tA:
28.8		 1sqfA-3a4tA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I

(Legionella
pneumophila) 		PF01150
(GDA1_CD39) 		6 ALA A  50
GLY A  54
GLY A  84
ILE A 154
ASP A 158
GLY A 156
 None
 1.42A 1sqfA-3aarA:
undetectable		 1sqfA-3aarA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bop BETA-NEUREXIN 2D4

(Mus musculus) 		PF02210
(Laminin_G_2) 		5 GLY A 185
GLY A 184
ILE A 153
ASP A 160
GLY A 151
 None
 0.96A 1sqfA-3bopA:
undetectable		 1sqfA-3bopA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 202
GLY A 203
ILE A 221
ASP A 222
ASP A 255
 None
None
MTA  A 401 (-3.8A)
None
MTA  A 401 (-3.6A)
 0.34A 1sqfA-3c6mA:
11.2		 1sqfA-3c6mA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjy PUTATIVE
THIOESTERASE

(Novosphingobium
aromaticivorans) 		PF13622
(4HBT_3) 		5 ALA A 153
GLY A 154
GLY A 155
ASP A 241
GLY A 244
 None
None
None
None
GOL  A 263 (-3.1A)
 0.93A 1sqfA-3cjyA:
undetectable		 1sqfA-3cjyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		5 ALA A 256
GLY A 254
ILE A 174
ASP A 236
ARG A 235
 None
 1.05A 1sqfA-3cwcA:
undetectable		 1sqfA-3cwcA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dho STREPTOGRAMIN A
ACETYLTRANSFERASE

(Enterococcus
faecium) 		PF00132
(Hexapep) 		5 ALA A 156
GLY A 157
GLY A 158
ASP A 136
GLY A 117
 None
B2M  A 302 (-3.5A)
B2M  A 302 (-4.0A)
None
None
 0.99A 1sqfA-3dhoA:
undetectable		 1sqfA-3dhoA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 GLY A 125
GLY A 124
ASP A 163
ASP A 166
ARG A 226
 KCX  A 146 ( 3.4A)
None
None
None
None
 0.90A 1sqfA-3e74A:
undetectable		 1sqfA-3e74A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		5 ALA A 153
GLY A 149
GLY A 148
ILE A  96
GLY A  93
 None
 1.02A 1sqfA-3edmA:
8.1		 1sqfA-3edmA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		6 GLY A 702
GLY A 703
ILE A 720
ASP A 721
ASP A 747
PRO A 765
 None
None
ADP  A   3 (-3.8A)
None
ADP  A   3 (-3.4A)
ADP  A   3 (-3.3A)
 0.63A 1sqfA-3egiA:
12.7		 1sqfA-3egiA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eja PROTEIN GH61E

(Thielavia
terrestris) 		PF03443
(Glyco_hydro_61) 		5 ALA A 181
GLY A 148
GLY A 149
GLY A 202
PRO A 184
 None
 1.05A 1sqfA-3ejaA:
undetectable		 1sqfA-3ejaA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 GLY A  42
ILE A  60
ASP A  61
ASP A  84
PRO A 103
 None
 0.71A 1sqfA-3fydA:
11.5		 1sqfA-3fydA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		6 GLY A  11
GLY A  12
ILE A  30
ASP A  31
ASP A  51
PRO A  78
 None
 0.87A 1sqfA-3g7uA:
9.7		 1sqfA-3g7uA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga7 ACETYL ESTERASE

(Salmonella
enterica) 		PF07859
(Abhydrolase_3) 		5 GLY A  94
GLY A  93
ASP A 222
ASP A 202
ARG A 207
 SEP  A 165 ( 3.5A)
SEP  A 165 ( 3.6A)
None
None
None
 0.84A 1sqfA-3ga7A:
2.9		 1sqfA-3ga7A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		6 GLY A 702
GLY A 703
ILE A 720
ASP A 721
ASP A 747
PRO A 765
 SAH  A 854 (-4.4A)
SAH  A 854 (-3.0A)
SAH  A 854 (-3.6A)
None
SAH  A 854 (-3.6A)
SAH  A 854 (-3.8A)
 0.68A 1sqfA-3gdhA:
13.5		 1sqfA-3gdhA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 GLY A  42
ILE A  60
ASP A  61
ASP A  84
PRO A 103
 None
SAM  A 300 (-3.9A)
None
SAM  A 300 (-3.7A)
SAM  A 300 (-3.8A)
 0.68A 1sqfA-3gryA:
11.5		 1sqfA-3gryA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hij DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
anthracis) 		PF00701
(DHDPS) 		5 ALA A  10
GLY A  45
GLY A  44
ILE A   7
GLY A   5
 KPI  A 163 ( 3.2A)
KPI  A 163 ( 3.4A)
None
None
None
 0.97A 1sqfA-3hijA:
undetectable		 1sqfA-3hijA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		5 ALA A 126
GLY A 101
ASP A 349
GLY A 350
ARG A 347
 AAE  A 501 (-3.7A)
None
None
None
None
 0.97A 1sqfA-3i09A:
2.5		 1sqfA-3i09A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		7 CYH A 113
ALA A 115
GLY A 117
GLY A 118
LYS A 119
ILE A 138
PRO A 184
 None
 0.45A 1sqfA-3m4xA:
31.2		 1sqfA-3m4xA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		6 ALA A 111
GLY A 113
GLY A 114
LYS A 115
ASP A 135
PRO A 179
 None
 0.52A 1sqfA-3m6xA:
33.6		 1sqfA-3m6xA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 ALA A 303
GLY A 302
GLY A 301
ASP A 265
GLY A 357
 None
None
None
MAN  A1039 ( 2.9A)
None
 1.03A 1sqfA-3ogrA:
undetectable		 1sqfA-3ogrA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 CYH A 501
ALA A 499
GLY A 498
GLY A 497
ILE A 786
 None
 1.02A 1sqfA-3opyA:
undetectable		 1sqfA-3opyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		5 GLY B 332
GLY B 333
ILE B 485
GLY B 483
PRO B 373
 None
 0.79A 1sqfA-3q75B:
undetectable		 1sqfA-3q75B:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvn MANGANESE-CONTAINING
SUPEROXIDE DISMUTASE

(Candida
albicans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ALA A  88
GLY A  94
GLY A  95
ILE A  13
ASP A  14
 None
 0.93A 1sqfA-3qvnA:
undetectable		 1sqfA-3qvnA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		6 GLY A 105
GLY A 106
ILE A 125
ASP A 126
ASP A 155
GLY A 156
 None
None
DSH  A 303 (-3.8A)
None
DSH  A 303 (-3.5A)
DSH  A 303 (-3.7A)
 0.53A 1sqfA-3rw9A:
9.1		 1sqfA-3rw9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t24 PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		5 GLY A 169
GLY A 168
ASP A 334
ASP A 331
GLY A 330
 None
 0.73A 1sqfA-3t24A:
undetectable		 1sqfA-3t24A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ALA A 119
GLY A 121
ASP A 111
GLY A 110
ARG A 109
 None
 0.86A 1sqfA-3u9sA:
2.5		 1sqfA-3u9sA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyk NDP-RHAMNOSYLTRANSFE
RASE

(Saccharopolyspora
spinosa) 		PF06722
(DUF1205) 		5 GLY A 293
GLY A 294
ILE A 331
GLY A 328
PRO A 307
 None
 1.04A 1sqfA-3uykA:
2.9		 1sqfA-3uykA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egt MAJOR CAPSID PROTEIN
VP60

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		5 ALA A 452
GLY A 270
GLY A 269
ASP A 531
GLY A 527
 None
 1.05A 1sqfA-4egtA:
undetectable		 1sqfA-4egtA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 GLY A  42
GLY A  41
ASP A 259
GLY A 303
ARG A 301
 None
 1.01A 1sqfA-4eygA:
undetectable		 1sqfA-4eygA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		9 CYH A 181
ALA A 183
GLY A 185
GLY A 186
LYS A 187
ASP A 237
GLY A 238
ARG A 239
PRO A 257
 SAM  A 401 (-3.9A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.5A)
None
SAM  A 401 (-4.0A)
 0.67A 1sqfA-4fzvA:
27.2		 1sqfA-4fzvA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g09 HISTIDINOL
DEHYDROGENASE

(Brucella suis) 		PF00815
(Histidinol_dh) 		5 ALA A 197
GLY A 199
ILE A 230
ASP A 231
GLY A 211
 None
 1.05A 1sqfA-4g09A:
2.5		 1sqfA-4g09A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		5 GLY A  67
GLY A  68
ASP A  87
ASP A 111
PRO A 143
 None
None
None
None
ACT  A 402 ( 4.9A)
 0.74A 1sqfA-4gc5A:
10.4		 1sqfA-4gc5A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ALA A 530
GLY A 518
GLY A 519
ILE A 533
ASP A 619
 None
 0.94A 1sqfA-4hvtA:
undetectable		 1sqfA-4hvtA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ALA A 530
GLY A 519
ILE A 533
ASP A 619
GLY A 612
 None
 1.00A 1sqfA-4hvtA:
undetectable		 1sqfA-4hvtA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 675
GLY A 674
ASP A 552
GLY A 555
ARG A 556
 None
 1.01A 1sqfA-4k3jA:
undetectable		 1sqfA-4k3jA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mup AMIDOHYDROLASE

(Agrobacterium
fabrum) 		PF04909
(Amidohydro_2) 		6 ALA A 126
GLY A 125
GLY A 124
ILE A  97
ASP A  98
GLY A 116
 None
 1.32A 1sqfA-4mupA:
undetectable		 1sqfA-4mupA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		6 ALA A 182
GLY A 157
GLY A 156
ILE A 296
GLY A 190
PRO A 300
 None
 1.26A 1sqfA-4pf1A:
undetectable		 1sqfA-4pf1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqh GLUTATHIONE
TRANSFERASE LAMBDA1

(Populus
trichocarpa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 GLY A 105
LYS A  49
ASP A 160
GLY A 166
PRO A 110
 None
 1.06A 1sqfA-4pqhA:
undetectable		 1sqfA-4pqhA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn3 TRIM5/CYCLOPHILIN A
FUSION PROTEIN/T4
LYSOZYME CHIMERA

(Macaca mulatta;
Escherichia
virus T4) 		PF00643
(zf-B_box)
PF00959
(Phage_lysozyme) 		5 ALA A 366
GLY A 331
GLY A 333
ASP A 364
GLY A 354
 None
 1.02A 1sqfA-4tn3A:
undetectable		 1sqfA-4tn3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 128
GLY A 129
ILE A 148
ASP A 149
ASP A 178
 None
None
MTA  A 401 (-3.8A)
None
MTA  A 401 (-3.2A)
 0.37A 1sqfA-4uoeA:
10.2		 1sqfA-4uoeA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18) 		5 ALA A 118
GLY A 117
GLY A 116
GLY A  45
ARG A  44
 MPD  A 402 ( 4.3A)
None
None
MPD  A 402 (-3.6A)
None
 1.04A 1sqfA-4w5zA:
undetectable		 1sqfA-4w5zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		6 GLY A  99
GLY A 100
ILE A 119
ASP A 120
ASP A 149
GLY A 150
 None
None
S4M  A 301 (-3.9A)
None
S4M  A 301 (-3.9A)
S4M  A 301 (-3.6A)
 0.47A 1sqfA-4yv2A:
9.5		 1sqfA-4yv2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zon VERRUCULOGEN
SYNTHASE

(Aspergillus
fumigatus) 		PF05721
(PhyH) 		5 ALA A 165
GLY A 208
GLY A 209
ILE A  32
PRO A 155
 None
 1.06A 1sqfA-4zonA:
undetectable		 1sqfA-4zonA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dss MP-4

(Mucuna pruriens) 		PF00197
(Kunitz_legume) 		5 ALA B 181
GLY B 182
GLY B 183
ILE B  23
GLY B 177
 None
 1.03A 1sqfA-5dssB:
undetectable		 1sqfA-5dssB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE

(Thermococcus
kodakarensis) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 GLY A 191
GLY A 192
ILE A 209
ASP A 235
PRO A 256
 None
SAM  A 400 (-3.7A)
SAM  A 400 (-3.9A)
SAM  A 400 (-3.4A)
SAM  A 400 (-4.2A)
 0.63A 1sqfA-5e72A:
14.8		 1sqfA-5e72A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		5 GLY A  84
GLY A  87
ASP A  78
ASP A  74
GLY A  73
 None
None
None
BEM  A 503 ( 3.7A)
None
 1.02A 1sqfA-5h71A:
undetectable		 1sqfA-5h71A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu6 HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR

(Trypanosoma
brucei) 		no annotation 5 ALA D 225
GLY D 222
GLY D 221
ASP D 232
GLY D 231
 None
 1.00A 1sqfA-5hu6D:
undetectable		 1sqfA-5hu6D:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 GLY A2038
GLY A2039
ILE A2150
GLY A2148
PRO A2046
 None
 1.03A 1sqfA-5i6hA:
undetectable		 1sqfA-5i6hA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 GLY A2038
GLY A2039
ILE A2150
GLY A2148
PRO A2046
 None
 1.04A 1sqfA-5i6iA:
undetectable		 1sqfA-5i6iA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 CYH A 381
GLY A 335
GLY A 336
ASP A 428
GLY A 429
 None
 0.96A 1sqfA-5ic7A:
undetectable		 1sqfA-5ic7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 5 GLY A 304
GLY A 303
ILE A 280
ASP A 309
GLY A 283
 None
 0.99A 1sqfA-5jvkA:
undetectable		 1sqfA-5jvkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN
CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1;
Rosellinia
necatrix
quadrivirus 1) 		no annotation
no annotation 		5 ALA B 189
GLY B 188
GLY B 187
ASP B 991
GLY A 505
 None
 0.79A 1sqfA-5nd1B:
undetectable		 1sqfA-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odb D10 FAB FRAGMENT -
LIGHT CHAIN

(Homo sapiens) 		no annotation 5 GLY B  99
GLY B 100
ASP B  92
ASP B  30
GLY B  29
 None
 0.84A 1sqfA-5odbB:
undetectable		 1sqfA-5odbB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsb MEMBRANE PROTEIN

(Bordetella
bronchiseptica) 		PF02535
(Zip) 		5 ALA A 184
GLY A 182
GLY A 243
ILE A 196
GLY A 192
 None
 1.04A 1sqfA-5tsbA:
undetectable		 1sqfA-5tsbA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13

(Homo sapiens) 		PF01564
(Spermine_synth) 		5 GLY A 504
ILE A 525
ASP A 526
ASP A 551
GLY A 552
 None
SAH  A 705 (-3.6A)
None
SAH  A 705 (-3.4A)
SAH  A 705 (-3.8A)
 0.95A 1sqfA-5wcjA:
11.4		 1sqfA-5wcjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13

(Homo sapiens) 		PF01564
(Spermine_synth) 		5 GLY A 505
ILE A 525
ASP A 526
ASP A 551
GLY A 552
 None
SAH  A 705 (-3.6A)
None
SAH  A 705 (-3.4A)
SAH  A 705 (-3.8A)
 0.43A 1sqfA-5wcjA:
11.4		 1sqfA-5wcjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		8 CYH A 242
ALA A 244
GLY A 246
GLY A 247
LYS A 248
ASP A 293
GLY A 294
PRO A 325
 None
None
None
None
C  C  72 ( 3.1A)
None
None
None
 0.58A 1sqfA-5wwtA:
31.2		 1sqfA-5wwtA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 5 GLY A 272
ASP A 260
ASP A 281
GLY A 278
ARG A 280
 None
 0.93A 1sqfA-5zb8A:
undetectable		 1sqfA-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER

(Yersinia pestis) 		no annotation 5 GLY A 242
GLY A 243
LYS A 244
ILE A 277
GLY A 273
 None
 1.04A 1sqfA-6b2yA:
undetectable		 1sqfA-6b2yA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1u PROTEIN (REVERSE
TRANSCRIPTASE)

(Murine leukemia
virus) 		PF00078
(RVT_1) 		3 PRO A 196
ASP A 200
ASP A 224
 None
 0.75A 1sqfA-1d1uA:
undetectable		 1sqfA-1d1uA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		3 PRO A  62
ASP A  83
ASP A 124
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.6A)
 0.34A 1sqfA-1eizA:
11.7		 1sqfA-1eizA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 PRO A 303
ASP A 306
ASP A 277
 None
MGD  A5002 (-3.0A)
MGD  A5002 (-2.8A)
 0.73A 1sqfA-1g8kA:
2.2		 1sqfA-1g8kA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 PRO A 635
ASP A 534
ASP A 574
 None
 0.80A 1sqfA-1h17A:
undetectable		 1sqfA-1h17A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcf NEUROTROPHIN-4

(Homo sapiens) 		PF00243
(NGF) 		3 PRO A  71
ASP A  64
ASP A  18
 None
 0.80A 1sqfA-1hcfA:
undetectable		 1sqfA-1hcfA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU) 		3 PRO A 139
ASP A 359
ASP A 521
 None
 0.77A 1sqfA-1iwpA:
undetectable		 1sqfA-1iwpA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1v CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Escherichia
coli) 		PF08299
(Bac_DnaA_C) 		3 PRO A 423
ASP A 427
ASP A 433
 None
 0.76A 1sqfA-1j1vA:
undetectable		 1sqfA-1j1vA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sd5 PUTATIVE
ANTITERMINATOR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF03861
(ANTAR) 		3 PRO A  69
ASP A  72
ASP A  65
 None
 0.76A 1sqfA-1sd5A:
3.0		 1sqfA-1sd5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgq STREPTOMYCES GRISEUS
PROTEINASE B

(Streptomyces
griseus) 		PF00089
(Trypsin) 		3 PRO E  99
ASP E 102
ASP E  60
 None
 0.80A 1sqfA-1sgqE:
undetectable		 1sqfA-1sgqE:
16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		3 PRO A 257
ASP A 277
ASP A 252
 None
 0.68A 1sqfA-1sqgA:
61.3		 1sqfA-1sqgA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		3 PRO A 257
ASP A 277
ASP A 322
 None
 0.44A 1sqfA-1sqgA:
61.3		 1sqfA-1sqgA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 PRO A 246
ASP A 249
ASP A 227
 None
2MD  A 800 (-3.1A)
2MD  A 800 (-2.8A)
 0.81A 1sqfA-1tmoA:
undetectable		 1sqfA-1tmoA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		3 PRO A 138
ASP A 358
ASP A 520
 None
 0.73A 1sqfA-1uc4A:
2.1		 1sqfA-1uc4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7w NUCLEOSIDE
DIPHOSPHATE KINASE

(Pisum sativum) 		PF00334
(NDK) 		3 PRO A 122
ASP A 120
ASP A 127
 None
 0.75A 1sqfA-1w7wA:
undetectable		 1sqfA-1w7wA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		3 PRO A  57
ASP A  52
ASP A  64
 None
None
5AD  B 500 ( 4.7A)
 0.68A 1sqfA-1xrsA:
undetectable		 1sqfA-1xrsA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]

(Yellow fever
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		3 PRO A 362
ASP A 359
ASP A 474
 None
 0.79A 1sqfA-1yksA:
2.3		 1sqfA-1yksA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 PRO A 237
ASP A 258
ASP A 305
 SAM  A1201 (-3.7A)
SAM  A1201 (-2.6A)
SAM  A1201 (-3.7A)
 0.41A 1sqfA-2b9eA:
26.7		 1sqfA-2b9eA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bol SMALL HEAT SHOCK
PROTEIN

(Taenia saginata) 		PF00011
(HSP20) 		3 PRO A 199
ASP A 102
ASP A  49
 None
 0.75A 1sqfA-2bolA:
undetectable		 1sqfA-2bolA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckn BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Mus musculus) 		PF00047
(ig) 		3 PRO A  82
ASP A  84
ASP A  79
 None
 0.66A 1sqfA-2cknA:
undetectable		 1sqfA-2cknA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpm PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1)

(Streptococcus
pneumoniae) 		PF02086
(MethyltransfD12) 		3 PRO A  42
ASP A  62
ASP A 177
 None
SAM  A 300 (-2.8A)
SAM  A 300 (-4.1A)
 0.77A 1sqfA-2dpmA:
8.1		 1sqfA-2dpmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		3 PRO A 125
ASP A 154
ASP A 180
 None
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
 0.78A 1sqfA-2f8lA:
11.8		 1sqfA-2f8lA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 PRO A 222
ASP A 225
ASP A 204
 MGD  A 812 (-4.5A)
MGD  A 812 (-3.4A)
MGD  A 812 (-2.7A)
 0.43A 1sqfA-2jirA:
2.5		 1sqfA-2jirA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		3 PRO A  33
ASP A  62
ASP A 104
 SAM  A 201 (-3.4A)
SAM  A 201 (-2.8A)
SAM  A 201 (-3.7A)
 0.31A 1sqfA-2nyuA:
11.8		 1sqfA-2nyuA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		3 PRO A  41
ASP A  61
ASP A  36
 None
SAH  A 301 (-2.7A)
SAH  A 301 ( 4.4A)
 0.81A 1sqfA-2p35A:
13.2		 1sqfA-2p35A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4v TRANSCRIPTION
ELONGATION FACTOR
GREB

(Escherichia
coli) 		PF01272
(GreA_GreB)
PF03449
(GreA_GreB_N) 		3 PRO A   4
ASP A 109
ASP A 121
 None
 0.76A 1sqfA-2p4vA:
undetectable		 1sqfA-2p4vA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis) 		PF00378
(ECH_1) 		3 PRO A 147
ASP A 202
ASP A 195
 None
 0.74A 1sqfA-2pg8A:
undetectable		 1sqfA-2pg8A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		3 PRO A  33
ASP A  55
ASP A 113
 SAM  A 203 (-3.5A)
SAM  A 203 (-2.8A)
SAM  A 203 (-3.6A)
 0.36A 1sqfA-2plwA:
12.4		 1sqfA-2plwA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]

(Haemophilus
influenzae) 		PF02153
(PDH) 		3 PRO A 153
ASP A 308
ASP A 302
 NAD  A 400 (-4.4A)
None
NAD  A 400 ( 4.7A)
 0.78A 1sqfA-2pv7A:
3.9		 1sqfA-2pv7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		3 PRO A 906
ASP A 903
ASP A 900
 None
CA  A1174 ( 2.5A)
CA  A   8 (-2.3A)
 0.76A 1sqfA-2rhpA:
undetectable		 1sqfA-2rhpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tpt THYMIDINE
PHOSPHORYLASE

(Escherichia
coli) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		3 PRO A 398
ASP A 394
ASP A 391
 None
 0.50A 1sqfA-2tptA:
undetectable		 1sqfA-2tptA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		3 PRO A  71
ASP A  95
ASP A 138
 SAH  A 400 (-3.7A)
SAH  A 400 (-2.6A)
SAH  A 400 (-3.7A)
 0.54A 1sqfA-2vp3A:
7.7		 1sqfA-2vp3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		3 PRO A  23
ASP A  44
ASP A  73
 None
None
FE2  A 401 ( 2.8A)
 0.68A 1sqfA-2vw8A:
undetectable		 1sqfA-2vw8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		3 PRO A 198
ASP A 136
ASP A 203
 None
 0.77A 1sqfA-2x66A:
undetectable		 1sqfA-2x66A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt9 PUTATIVE SIGNAL
TRANSDUCTION PROTEIN
GARA

(Mycolicibacterium
smegmatis) 		PF00498
(FHA) 		3 PRO B  74
ASP B  72
ASP B  85
 None
 0.76A 1sqfA-2xt9B:
undetectable		 1sqfA-2xt9B:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xva TELLURITE RESISTANCE
PROTEIN TEHB

(Escherichia
coli) 		PF03848
(TehB) 		3 PRO A  31
ASP A  97
ASP A  54
 None
 0.64A 1sqfA-2xvaA:
11.5		 1sqfA-2xvaA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 PRO A 162
ASP A 159
ASP A 164
 None
None
SO4  A1995 (-2.7A)
 0.61A 1sqfA-2xvgA:
undetectable		 1sqfA-2xvgA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5

(Homo sapiens) 		PF16669
(TTC5_OB) 		3 PRO A 363
ASP A 361
ASP A 359
 None
 0.79A 1sqfA-2xvsA:
undetectable		 1sqfA-2xvsA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		3 PRO A 427
ASP A 429
ASP A 471
 None
 0.71A 1sqfA-2y35A:
2.1		 1sqfA-2y35A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		3 PRO A 270
ASP A 291
ASP A 337
 SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.6A)
 0.48A 1sqfA-2yxlA:
40.8		 1sqfA-2yxlA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 3 PRO A 260
ASP A 258
ASP A 324
 None
 0.70A 1sqfA-3a0fA:
undetectable		 1sqfA-3a0fA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3p METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF01596
(Methyltransf_3) 		3 PRO A  62
ASP A  87
ASP A 115
 None
EDO  A 215 (-3.0A)
None
 0.72A 1sqfA-3c3pA:
10.7		 1sqfA-3c3pA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 PRO A  70
ASP A  67
ASP A  75
 None
 0.73A 1sqfA-3cmmA:
5.0		 1sqfA-3cmmA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		3 PRO A  49
ASP A  67
ASP A 111
 SAM  A   1 (-3.5A)
SAM  A   1 (-2.7A)
SAM  A   1 (-3.7A)
 0.35A 1sqfA-3douA:
7.2		 1sqfA-3douA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK

(Escherichia
coli) 		PF00106
(adh_short) 		3 PRO A 114
ASP A 105
ASP A 119
 None
 0.66A 1sqfA-3f1kA:
8.0		 1sqfA-3f1kA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fby CARTILAGE OLIGOMERIC
MATRIX PROTEIN

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		3 PRO A 478
ASP A 475
ASP A 472
 None
CA  A 823 ( 2.7A)
CA  A 821 (-2.7A)
 0.77A 1sqfA-3fbyA:
undetectable		 1sqfA-3fbyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g20 TYPE II SECRETION
PROTEIN

(Escherichia
coli) 		PF08334
(T2SSG) 		3 PRO A 103
ASP A 110
ASP A 108
 None
 0.73A 1sqfA-3g20A:
undetectable		 1sqfA-3g20A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile) 		PF01170
(UPF0020)
PF02926
(THUMP) 		3 PRO A 199
ASP A 261
ASP A 289
 None
GTP  A 383 (-3.0A)
GTP  A 383 ( 3.8A)
 0.77A 1sqfA-3lduA:
10.6		 1sqfA-3lduA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhl PUTATIVE AGMATINASE

(Clostridioides
difficile) 		PF00491
(Arginase) 		3 PRO A  59
ASP A  62
ASP A  64
 None
 0.81A 1sqfA-3lhlA:
undetectable		 1sqfA-3lhlA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mam OSMOPROTECTION
PROTEIN (PROX)

(Archaeoglobus
fulgidus) 		PF04069
(OpuAC) 		3 PRO A 213
ASP A 206
ASP A 151
 None
 0.66A 1sqfA-3mamA:
undetectable		 1sqfA-3mamA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		3 PRO A 129
ASP A  42
ASP A 134
 None
 0.69A 1sqfA-3ml0A:
undetectable		 1sqfA-3ml0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mve UPF0255 PROTEIN
VV1_0328

(Vibrio
vulnificus) 		PF06500
(DUF1100) 		3 PRO A 298
ASP A 373
ASP A 366
 EDO  A 417 ( 4.7A)
None
None
 0.81A 1sqfA-3mveA:
undetectable		 1sqfA-3mveA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		3 PRO A 949
ASP A 708
ASP A 931
 None
 0.79A 1sqfA-3opyA:
undetectable		 1sqfA-3opyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poh ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F1

(Bacteroides
thetaiotaomicron) 		PF08522
(DUF1735) 		3 PRO A 469
ASP A 466
ASP A 475
 None
 0.66A 1sqfA-3pohA:
undetectable		 1sqfA-3pohA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		3 PRO A 130
ASP A 135
ASP A 125
 None
 0.77A 1sqfA-3vm5A:
undetectable		 1sqfA-3vm5A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		3 PRO A 386
ASP A 391
ASP A 416
 None
 0.74A 1sqfA-3wbkA:
undetectable		 1sqfA-3wbkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj7 PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF01370
(Epimerase) 		3 PRO A 320
ASP A 219
ASP A 327
 None
 0.80A 1sqfA-3wj7A:
6.3		 1sqfA-3wj7A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg4 ERFK/YBIS/YCFS/YNHG

(Enterococcus
faecium) 		PF03734
(YkuD) 		3 PRO A 406
ASP A 422
ASP A 390
 None
 0.78A 1sqfA-3zg4A:
undetectable		 1sqfA-3zg4A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Mycoplasma
penetrans) 		PF00145
(DNA_methylase) 		3 PRO A 258
ASP A 223
ASP A 263
 None
 0.74A 1sqfA-4dkjA:
7.1		 1sqfA-4dkjA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvg DIAPHANOUS PROTEIN

(Entamoeba
histolytica) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		3 PRO B 317
ASP B 315
ASP B 267
 None
 0.74A 1sqfA-4dvgB:
undetectable		 1sqfA-4dvgB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 PRO A 142
ASP A 296
ASP A 334
 None
 0.76A 1sqfA-4ewtA:
undetectable		 1sqfA-4ewtA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 PRO A 185
ASP A 204
ASP A 255
 SAM  A 401 (-3.6A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.7A)
 0.25A 1sqfA-4fzvA:
27.1		 1sqfA-4fzvA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hlj ROUNDABOUT HOMOLOG 1

(Homo sapiens) 		PF00041
(fn3) 		3 PRO A 877
ASP A 872
ASP A 882
 None
 0.74A 1sqfA-4hljA:
undetectable		 1sqfA-4hljA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iob DIGUANYLATE CYCLASE
TPBB

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		3 PRO A 338
ASP A 322
ASP A 344
 None
 0.75A 1sqfA-4iobA:
undetectable		 1sqfA-4iobA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		3 PRO A 281
ASP A 276
ASP A 303
 None
 0.75A 1sqfA-4irtA:
undetectable		 1sqfA-4irtA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica) 		PF02917
(Pertussis_S1) 		3 PRO G  29
ASP G  26
ASP G  36
 None
 0.74A 1sqfA-4k6lG:
undetectable		 1sqfA-4k6lG:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		3 PRO A 786
ASP A 791
ASP A 816
 None
 0.73A 1sqfA-4n3sA:
undetectable		 1sqfA-4n3sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmn REPLICATIVE DNA
HELICASE

(Aquifex
aeolicus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		3 PRO A 290
ASP A 287
ASP A 296
 None
 0.80A 1sqfA-4nmnA:
undetectable		 1sqfA-4nmnA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npk EXTENDED
SYNAPTOTAGMIN-2

(Homo sapiens) 		PF00168
(C2) 		3 PRO A 463
ASP A 466
ASP A 413
 None
CA  A 803 (-3.1A)
CA  A 801 (-3.3A)
 0.77A 1sqfA-4npkA:
undetectable		 1sqfA-4npkA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opf NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 PRO A6380
ASP A6371
ASP A6512
 None
 0.71A 1sqfA-4opfA:
undetectable		 1sqfA-4opfA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2b ENDO-1,4-BETA-D-GLUC
ANASE

(Pseudomonas
putida) 		PF01270
(Glyco_hydro_8) 		3 PRO A 219
ASP A 241
ASP A 286
 None
 0.77A 1sqfA-4q2bA:
undetectable		 1sqfA-4q2bA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		3 PRO A 358
ASP A 450
ASP A 483
 None
 0.76A 1sqfA-4q2cA:
undetectable		 1sqfA-4q2cA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1u CINNAMOYL COA
REDUCTASE

(Medicago
truncatula) 		PF01370
(Epimerase) 		3 PRO A 295
ASP A 221
ASP A 302
 None
 0.79A 1sqfA-4r1uA:
5.7		 1sqfA-4r1uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txv THIOL:DISULFIDE
INTERCHANGE PROTEIN
TLPA

(Bradyrhizobium
diazoefficiens) 		PF08534
(Redoxin) 		3 PRO A  87
ASP A  82
ASP A  92
 None
 0.72A 1sqfA-4txvA:
undetectable		 1sqfA-4txvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj6 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		3 PRO A 372
ASP A 443
ASP A 491
 None
 0.81A 1sqfA-4uj6A:
undetectable		 1sqfA-4uj6A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whi BETA-LACTAMASE

(Mycobacterium
tuberculosis) 		PF11954
(DUF3471) 		3 PRO A 444
ASP A 489
ASP A 491
 None
 0.60A 1sqfA-4whiA:
undetectable		 1sqfA-4whiA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		3 PRO A 487
ASP A  52
ASP A 301
 None
 0.73A 1sqfA-4wmjA:
undetectable		 1sqfA-4wmjA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj5 CYCLIC AMP-GMP
SYNTHASE

(Vibrio cholerae) 		no annotation 3 PRO A 261
ASP A 345
ASP A 266
 GH3  A1013 ( 3.9A)
GH3  A1014 ( 4.4A)
None
 0.77A 1sqfA-4xj5A:
undetectable		 1sqfA-4xj5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 3 PRO A 257
ASP A 341
ASP A 262
 GH3  A 504 ( 4.1A)
None
None
 0.52A 1sqfA-4xj6A:
undetectable		 1sqfA-4xj6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA

(Escherichia
coli) 		PF02917
(Pertussis_S1) 		3 PRO A  14
ASP A  11
ASP A  21
 None
 0.80A 1sqfA-4z9cA:
undetectable		 1sqfA-4z9cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		3 PRO A 233
ASP A 228
ASP A 238
 None
 0.80A 1sqfA-5a5gA:
undetectable		 1sqfA-5a5gA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brj TWO COMPONENT
RESPONSE REGULATOR

(Agrobacterium
tumefaciens) 		PF00072
(Response_reg) 		3 PRO A  69
ASP A  72
ASP A  65
 None
None
MG  A 201 (-2.5A)
 0.77A 1sqfA-5brjA:
3.2		 1sqfA-5brjA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d95 AMINOTRANSFERASE
CLASS-III

(Sphaerobacter
thermophilus) 		PF00202
(Aminotran_3) 		3 PRO A 337
ASP A 341
ASP A 263
 None
 0.74A 1sqfA-5d95A:
undetectable		 1sqfA-5d95A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dih MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		PF00936
(BMC) 		3 PRO A   5
ASP A   9
ASP A 106
 None
 0.67A 1sqfA-5dihA:
undetectable		 1sqfA-5dihA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 PRO A  32
ASP A 333
ASP A  35
 None
None
EDO  A1874 ( 4.5A)
 0.64A 1sqfA-5fjiA:
undetectable		 1sqfA-5fjiA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 PRO A  33
ASP A 333
ASP A  36
 None
 0.41A 1sqfA-5fjjA:
undetectable		 1sqfA-5fjjA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 PRO B 128
ASP B 124
ASP C 645
 None
 0.77A 1sqfA-5g5gB:
undetectable		 1sqfA-5g5gB:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hi8 ANTENNA PROTEIN

(Prochlorococcus
phage P-HM1) 		PF06206
(CpeT) 		3 PRO A  74
ASP A  77
ASP A  60
 None
MG  A 201 ( 4.2A)
None
 0.56A 1sqfA-5hi8A:
undetectable		 1sqfA-5hi8A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		3 PRO A 281
ASP A 276
ASP A 303
 None
 0.78A 1sqfA-5mulA:
undetectable		 1sqfA-5mulA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus) 		PF15892
(BNR_4) 		3 PRO A 281
ASP A 276
ASP A 303
 None
 0.73A 1sqfA-5mvhA:
undetectable		 1sqfA-5mvhA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		3 PRO A 116
ASP A 118
ASP A  52
 None
 0.81A 1sqfA-5pepA:
undetectable		 1sqfA-5pepA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tta PUTATIVE EXPORTED
PROTEIN

(Clostridioides
difficile) 		no annotation 3 PRO A 150
ASP A 120
ASP A 218
 None
 0.79A 1sqfA-5ttaA:
undetectable		 1sqfA-5ttaA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 PRO A  71
ASP A  68
ASP A  76
 None
 0.78A 1sqfA-5um6A:
4.0		 1sqfA-5um6A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 3 PRO A 543
ASP A 564
ASP A 490
 None
 0.74A 1sqfA-5vhaA:
2.4		 1sqfA-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 PRO A 245
ASP A 266
ASP A 323
 C  C  72 ( 4.7A)
None
C  C  72 ( 2.8A)
 0.40A 1sqfA-5wwtA:
17.4		 1sqfA-5wwtA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 3 PRO C 290
ASP C 308
ASP C 359
 None
 0.38A 1sqfA-5x6xC:
4.0		 1sqfA-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ct0 DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 PRO 0 599
ASP 0 607
ASP 0 601
 None
 0.71A 1sqfA-6ct00:
undetectable		 1sqfA-6ct00:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 3 PRO A 273
ASP A 276
ASP A 255
 MGD  A 902 (-4.0A)
MGD  A 902 (-1.9A)
MGD  A 902 (-2.3A)
 0.81A 1sqfA-6czaA:
undetectable		 1sqfA-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP4

(Homo sapiens) 		no annotation 3 PRO H 190
ASP H 188
ASP H 253
 None
 0.78A 1sqfA-6d6qH:
undetectable		 1sqfA-6d6qH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1d COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		no annotation 3 PRO A 199
ASP A 236
ASP A 277
 None
CA  A 300 (-2.2A)
None
 0.77A 1sqfA-6f1dA:
undetectable		 1sqfA-6f1dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 3 PRO B 546
ASP B 558
ASP B 550
 None
 0.58A 1sqfA-6fosB:
undetectable		 1sqfA-6fosB:
undetectable