SIMILAR PATTERNS OF AMINO ACIDS FOR 1SQ5_D_PAUD6004_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		5 VAL A  22
ASP A 276
LEU A 319
HIS A 269
LEU A  29
 None
None
None
CIT  A 379 ( 4.0A)
None
 1.39A 1sq5D-1a59A:
undetectable		 1sq5D-1a59A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 126
GLY A 233
LEU A 128
TYR A 123
ILE A 229
 None
FAD  A 600 (-3.8A)
None
None
None
 1.27A 1sq5D-1bhyA:
0.2		 1sq5D-1bhyA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 ASP A 101
GLY A  98
HIS A  77
LEU A 119
ILE A 169
 None
 1.27A 1sq5D-1inlA:
0.0		 1sq5D-1inlA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sq5 PANTOTHENATE KINASE

(Escherichia
coli) 		PF00485
(PRK) 		10 VAL A1097
ASP A1127
LEU A1130
LYS A1145
GLY A1146
HIS A1177
LEU A1201
TYR A1240
ILE A1281
ASN A1282
 ADP  A5001 ( 4.4A)
PAU  A6001 (-2.9A)
None
None
PAU  A6001 (-3.3A)
PAU  A6001 (-4.2A)
None
PAU  A6001 (-4.3A)
PAU  A6001 (-3.7A)
PAU  A6001 (-3.0A)
 0.10A 1sq5D-1sq5A:
49.2		 1sq5D-1sq5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		6 VAL A 356
LEU A 317
GLY A 342
LEU A 354
TYR A 361
ILE A 339
 None
 1.18A 1sq5D-1u2xA:
0.0		 1sq5D-1u2xA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6y ENDO-1,4-BETA-D-XYLA
NASE AND
ENDO-1,4-BETA-XYLANA
SE B

(Cellulomonas
fimi;
Streptomyces
olivaceoviridis) 		PF00331
(Glyco_hydro_10) 		5 VAL A 296
GLY A 276
LEU A 295
TYR A 307
ILE A  33
 None
 1.41A 1sq5D-1v6yA:
0.0		 1sq5D-1v6yA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664

(Listeria
innocua) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A1297
ASP A1327
LEU A1013
TYR A1045
ILE A1009
 None
 1.32A 1sq5D-1wufA:
0.0		 1sq5D-1wufA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		5 VAL A 195
LEU A 274
LEU A 193
ILE A 252
ASN A 249
 None
 1.46A 1sq5D-1yniA:
undetectable		 1sq5D-1yniA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE

(Cellulomonas
fimi) 		PF00331
(Glyco_hydro_10) 		5 VAL A 294
GLY A 274
LEU A 293
TYR A 305
ILE A  32
 None
 1.39A 1sq5D-2hisA:
0.0		 1sq5D-2hisA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n32 NISIN IMMUNITY
PROTEIN

(Lactococcus
lactis) 		no annotation 5 VAL A  70
ASP A  88
GLY A  85
TYR A  46
ASN A  72
 None
 1.45A 1sq5D-2n32A:
undetectable		 1sq5D-2n32A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		5 ASP A  12
LEU A   8
GLY A  15
HIS A 269
LEU A 375
 None
 1.36A 1sq5D-2o04A:
undetectable		 1sq5D-2o04A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otp LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY A
MEMBER 2

(Homo sapiens) 		PF13895
(Ig_2) 		5 LYS A  55
GLY A  54
LEU A  30
TYR A  35
ILE A  50
 None
 1.37A 1sq5D-2otpA:
undetectable		 1sq5D-2otpA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x49 INVASION PROTEIN
INVA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		5 VAL A 432
GLY A 464
LEU A 474
TYR A 435
ILE A 444
 None
 1.10A 1sq5D-2x49A:
undetectable		 1sq5D-2x49A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1t IRON(II) TRANSPORT
PROTEIN B

(Thermotoga
maritima) 		PF02421
(FeoB_N) 		5 VAL A 101
ASP A  69
LEU A  67
LEU A  32
ILE A 125
 None
 1.19A 1sq5D-3a1tA:
undetectable		 1sq5D-3a1tA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b43 TITIN

(Oryctolagus
cuniculus) 		PF07679
(I-set) 		5 VAL A 253
GLY A 238
LEU A 254
TYR A 264
ILE A 234
 None
 1.45A 1sq5D-3b43A:
undetectable		 1sq5D-3b43A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gff IROE-LIKE SERINE
HYDROLASE

(Shewanella
oneidensis) 		PF00756
(Esterase) 		5 VAL A 141
GLY A 253
HIS A  56
LEU A 167
ILE A 258
 None
 1.45A 1sq5D-3gffA:
undetectable		 1sq5D-3gffA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyl TELOMERASE REVERSE
TRANSCRIPTASE

(Tribolium
castaneum) 		PF00078
(RVT_1)
PF12009
(Telomerase_RBD) 		5 ASP A 310
LEU A 306
GLY A 314
HIS A 287
ILE A 216
 None
None
G  E   3 ( 4.6A)
None
None
 1.29A 1sq5D-3kylA:
undetectable		 1sq5D-3kylA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw9 INVASION PROTEIN
INVA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		5 VAL A 432
GLY A 464
LEU A 474
TYR A 435
ILE A 444
 None
 1.32A 1sq5D-3lw9A:
undetectable		 1sq5D-3lw9A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Shewanella
frigidimarina) 		PF04952
(AstE_AspA) 		5 ASP A 171
HIS A 173
LEU A 159
ILE A  81
ASN A  77
 None
ZN  A 374 (-3.1A)
None
None
None
 1.22A 1sq5D-3lwuA:
undetectable		 1sq5D-3lwuA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p09 BETA-LACTAMASE

(Francisella
tularensis) 		PF13354
(Beta-lactamase2) 		5 VAL A  68
LEU A  67
TYR A 202
ILE A 112
ASN A 116
 None
 1.43A 1sq5D-3p09A:
undetectable		 1sq5D-3p09A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tju GRANZYME H

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A 157
LEU A 211
GLY A 192
LEU A 159
ILE A  17
 None
 1.36A 1sq5D-3tjuA:
undetectable		 1sq5D-3tjuA:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tqc PANTOTHENATE KINASE

(Coxiella
burnetii) 		PF00485
(PRK) 		10 VAL A  98
ASP A 128
LEU A 131
LYS A 146
GLY A 147
HIS A 178
LEU A 202
TYR A 241
ILE A 282
ASN A 283
 ADP  A 500 ( 4.4A)
None
None
None
None
None
None
None
None
None
 0.69A 1sq5D-3tqcA:
41.2		 1sq5D-3tqcA:
52.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		5 LYS A 541
GLY A 540
LEU A 295
ILE A 545
ASN A 738
 None
 1.38A 1sq5D-4a01A:
undetectable		 1sq5D-4a01A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoy ISOCITRATE
DEHYDROGENASE [NADP]

(Ruminiclostridium
thermocellum) 		PF00180
(Iso_dh) 		5 VAL A  69
ASP A 344
LEU A 349
LEU A  10
TYR A 300
 None
 1.17A 1sq5D-4aoyA:
undetectable		 1sq5D-4aoyA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA

(Mycobacterium
tuberculosis) 		PF00925
(GTP_cyclohydro2)
PF00926
(DHBP_synthase) 		5 VAL A 349
ASP A 370
GLY A 344
LEU A 348
ILE A 209
 None
 1.24A 1sq5D-4i14A:
undetectable		 1sq5D-4i14A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kku MEMBRANE FUSION
PROTEIN

(Borreliella
burgdorferi) 		PF13533
(Biotin_lipoyl_2)
PF16576
(HlyD_D23) 		5 VAL A 145
ASP A  69
GLY A 147
LEU A 127
ILE A 122
 None
 1.35A 1sq5D-4kkuA:
undetectable		 1sq5D-4kkuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 VAL A 174
LEU A 167
LEU A 193
TYR A 178
ILE A 241
 None
 1.47A 1sq5D-4q0cA:
undetectable		 1sq5D-4q0cA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7q LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Chitinophaga
pinensis) 		PF13472
(Lipase_GDSL_2) 		5 ASP A 251
LEU A 253
LEU A  34
ILE A 263
ASN A 260
 None
 1.46A 1sq5D-4q7qA:
undetectable		 1sq5D-4q7qA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uir OLEATE HYDRATASE

(Elizabethkingia
meningoseptica) 		PF06100
(MCRA) 		5 VAL A 536
LEU A 564
GLY A 534
LEU A 535
ILE A  67
 None
 1.49A 1sq5D-4uirA:
undetectable		 1sq5D-4uirA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola) 		PF01344
(Kelch_1)
PF09118
(DUF1929) 		5 ASP A  81
GLY A 129
LEU A 482
TYR A 461
ILE A 457
 None
 1.42A 1sq5D-5c92A:
undetectable		 1sq5D-5c92A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		5 VAL A 346
LEU A 364
LEU A 347
TYR A 468
ILE A 353
 None
 1.44A 1sq5D-5djsA:
undetectable		 1sq5D-5djsA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 VAL A 182
LEU A 290
HIS A 298
LEU A 179
ILE A 283
 None
 1.50A 1sq5D-5ehkA:
undetectable		 1sq5D-5ehkA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		5 ASP A 265
LEU A 260
HIS A 324
LEU A 241
ILE A 320
 None
 1.38A 1sq5D-5es6A:
undetectable		 1sq5D-5es6A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 ASP A 532
LEU A 528
LEU A 502
TYR A 491
ILE A 473
 None
 1.34A 1sq5D-5hm5A:
undetectable		 1sq5D-5hm5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		no annotation 5 ASP C 265
LEU C 260
HIS C 324
LEU C 241
ILE C 320
 None
 1.38A 1sq5D-5jnfC:
undetectable		 1sq5D-5jnfC:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		5 VAL S 419
LYS S 453
GLY S 470
LEU S 456
ILE S 472
 None
 1.45A 1sq5D-5k0yS:
undetectable		 1sq5D-5k0yS:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Legionella
pneumophila) 		PF00290
(Trp_syntA) 		5 LEU A  99
GLY A 125
LEU A 148
ILE A   4
ASN A   2
 None
 1.35A 1sq5D-5k9xA:
undetectable		 1sq5D-5k9xA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkg ANCMT E72A

(synthetic
construct) 		PF04587
(ADP_PFK_GK) 		5 VAL A 335
LEU A 296
GLY A 320
TYR A 340
ILE A 318
 None
 1.32A 1sq5D-5kkgA:
undetectable		 1sq5D-5kkgA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrj BETA-XYLANASE

(Acremonium
chrysogenum) 		no annotation 5 VAL A 237
LEU A 181
LYS A 186
LEU A 194
ASN A 189
 None
 1.25A 1sq5D-5mrjA:
undetectable		 1sq5D-5mrjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 VAL A 690
GLY A 614
LEU A 613
TYR A 688
ILE A 617
 None
 1.49A 1sq5D-5n4lA:
undetectable		 1sq5D-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 5 ASP A 275
GLY A 200
HIS A 193
LEU A 201
ILE A 162
 None
 1.32A 1sq5D-5ns8A:
undetectable		 1sq5D-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 5 VAL A 347
LEU A 307
GLY A 331
TYR A 352
ILE A 329
 None
 1.36A 1sq5D-5od2A:
undetectable		 1sq5D-5od2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj3 -

(-) 		no annotation 5 ASP A 278
LYS A 326
GLY A 327
HIS A 280
ASN A 343
 None
 1.42A 1sq5D-5oj3A:
undetectable		 1sq5D-5oj3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A2237
GLY A  94
LEU A2233
TYR A2240
ASN A2241
 None
 1.19A 1sq5D-5tzyA:
undetectable		 1sq5D-5tzyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)

(Neisseria
gonorrhoeae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 121
GLY A 228
LEU A 123
TYR A 118
ILE A 224
 None
FAD  A 601 (-3.8A)
FAD  A 601 (-4.9A)
None
None
 1.24A 1sq5D-5u25A:
undetectable		 1sq5D-5u25A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 VAL A 279
LEU A 401
GLY A 355
HIS A 410
ILE A 328
 NAD  A 501 (-3.6A)
NAD  A 501 (-4.1A)
NAD  A 501 (-3.4A)
SAH  A 502 ( 3.5A)
None
 1.14A 1sq5D-5utuA:
undetectable		 1sq5D-5utuA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmb PANTOTHENATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 8 VAL A  99
ASP A 129
LEU A 132
GLY A 148
LEU A 203
TYR A 235
ILE A 276
ASN A 277
 SO4  A 401 ( 4.2A)
None
None
None
None
None
None
None
 0.86A 1sq5D-5xmbA:
35.9		 1sq5D-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmb PANTOTHENATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 5 VAL A  99
ASP A 129
LEU A 132
HIS A 179
LEU A 203
 SO4  A 401 ( 4.2A)
None
None
None
None
 0.94A 1sq5D-5xmbA:
35.9		 1sq5D-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmb PANTOTHENATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 6 VAL A  99
ASP A 129
LYS A 147
TYR A 235
ILE A 276
ASN A 277
 SO4  A 401 ( 4.2A)
None
None
None
None
None
 0.90A 1sq5D-5xmbA:
35.9		 1sq5D-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C) 		no annotation 5 LEU U  51
GLY U  49
HIS U 276
TYR U 362
ASN U 242
 None
 1.31A 1sq5D-5zvtU:
undetectable		 1sq5D-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 5 VAL B 170
LEU B 122
GLY B 250
LEU B 167
ILE B 248
 None
 0.93A 1sq5D-6evjB:
undetectable		 1sq5D-6evjB:
undetectable