SIMILAR PATTERNS OF AMINO ACIDS FOR 1SN5_C_T3C601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)

(Malus domestica) 		PF00155
(Aminotran_1_2) 		4 LEU A 213
GLU A 248
LEU A 216
VAL A 267
 None
 1.12A 1sn5A-1b8gA:
0.0		 1sn5A-1b8gA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE

(Penicillium
roqueforti) 		no annotation 4 LYS A 321
LEU A  95
GLU A 324
ALA A 318
 None
 1.19A 1sn5A-1dgpA:
undetectable		 1sn5A-1dgpA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 LYS A 213
ALA A 212
LEU A 216
VAL A  26
 None
 1.12A 1sn5A-1dgsA:
0.0		 1sn5A-1dgsA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 LYS A1315
GLU A1319
ALA A1314
VAL A1431
 None
 1.11A 1sn5A-1e6yA:
0.0		 1sn5A-1e6yA:
12.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
VAL A 121
 None
 0.60A 1sn5A-1gkeA:
19.7		 1sn5A-1gkeA:
56.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mab PROTEIN (F1-ATPASE
BETA CHAIN)

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 LYS B 175
ALA B 174
LEU B 169
VAL B 215
 None
 1.02A 1sn5A-1mabB:
undetectable		 1sn5A-1mabB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		4 LEU A 292
GLU A 331
LEU A 369
VAL A 166
 None
 1.15A 1sn5A-1sjpA:
undetectable		 1sn5A-1sjpA:
14.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
VAL A 121
 None
 0.13A 1sn5A-1sn2A:
25.0		 1sn5A-1sn2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
VAL A 121
 None
 0.37A 1sn5A-1tfpA:
18.7		 1sn5A-1tfpA:
62.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		4 GLU A 167
ALA A  52
LEU A 105
VAL A  98
 None
 1.10A 1sn5A-1un9A:
undetectable		 1sn5A-1un9A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 LYS A 218
ALA A 217
LEU A 221
VAL A  26
 None
 1.08A 1sn5A-1v9pA:
undetectable		 1sn5A-1v9pA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		4 LYS A 218
GLU A 217
ALA A 220
VAL A 189
 None
 0.94A 1sn5A-1vefA:
undetectable		 1sn5A-1vefA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgq FORMYL-COENZYME A
TRANSFERASE

(Oxalobacter
formigenes) 		PF02515
(CoA_transf_3) 		4 LEU A 207
ALA A 203
LEU A 167
VAL A 198
 None
 1.00A 1sn5A-1vgqA:
undetectable		 1sn5A-1vgqA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 LYS A 931
GLU A 935
ALA A 926
VAL A 842
 None
 1.12A 1sn5A-1wz2A:
undetectable		 1sn5A-1wz2A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB

(Mycobacterium
tuberculosis) 		PF02518
(HATPase_c) 		4 LEU A 328
ALA A 367
LEU A 365
VAL A 374
 None
 1.01A 1sn5A-1ysrA:
undetectable		 1sn5A-1ysrA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6o FERRITIN HEAVY CHAIN

(Trichoplusia ni) 		PF00210
(Ferritin) 		4 GLU M  66
ALA M  35
LEU M  37
VAL M 119
 None
 1.08A 1sn5A-1z6oM:
undetectable		 1sn5A-1z6oM:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap9 ACETYLGLUTAMATE
KINASE

(Mycobacterium
tuberculosis) 		PF00696
(AA_kinase) 		4 LYS A 292
GLU A 233
ALA A 268
LEU A 212
 None
 1.08A 1sn5A-2ap9A:
undetectable		 1sn5A-2ap9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckx TELOMERE BINDING
PROTEIN TBP1

(Nicotiana
tabacum) 		PF00249
(Myb_DNA-binding) 		4 LYS A 604
LEU A 619
ALA A 607
LEU A 588
 None
 1.20A 1sn5A-2ckxA:
undetectable		 1sn5A-2ckxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		4 LEU A  84
GLU A  43
LEU A  90
VAL A  98
 None
 1.20A 1sn5A-2cyaA:
undetectable		 1sn5A-2cyaA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 319
ALA A 122
LEU A   4
VAL A 125
 None
 1.20A 1sn5A-2ejvA:
undetectable		 1sn5A-2ejvA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 LEU A  93
GLU A 323
LEU A  90
VAL A  82
 None
 1.19A 1sn5A-2f3oA:
undetectable		 1sn5A-2f3oA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk4 CONSERVED
HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF04127
(DFP) 		4 LYS A 158
LEU A 160
ALA A 186
VAL A 202
 None
 0.70A 1sn5A-2gk4A:
undetectable		 1sn5A-2gk4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfd HYDROGENASE-1 OPERON
PROTEIN HYAE

(Escherichia
coli) 		PF07449
(HyaE) 		4 GLU A  24
ALA A  75
LEU A  77
VAL A  39
 None
 1.13A 1sn5A-2hfdA:
undetectable		 1sn5A-2hfdA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 LYS B  45
GLU B  49
ALA B  44
VAL B  83
 None
 1.16A 1sn5A-2i2xB:
undetectable		 1sn5A-2i2xB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ma4 PUTATIVE PERIPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07338
(DUF1471) 		4 LYS A  65
GLU A  64
ALA A  67
VAL A  70
 None
 1.19A 1sn5A-2ma4A:
undetectable		 1sn5A-2ma4A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mr6 DE NOVO DESIGNED
PROTEIN OR462

(synthetic
construct) 		no annotation 4 LYS A 116
GLU A  21
ALA A 115
VAL A   7
 None
 1.20A 1sn5A-2mr6A:
undetectable		 1sn5A-2mr6A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 GLU A 174
ALA A 160
LEU A 214
VAL A 197
 None
 1.14A 1sn5A-2og2A:
undetectable		 1sn5A-2og2A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		4 GLU A 117
ALA A 161
LEU A 165
VAL A 157
 None
 1.14A 1sn5A-2pd3A:
undetectable		 1sn5A-2pd3A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		4 LYS A 397
ALA A 416
LEU A 418
VAL A 414
 None
 1.06A 1sn5A-2wn4A:
undetectable		 1sn5A-2wn4A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE

(Homo sapiens) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 LYS A 183
ALA A 184
LEU A 176
VAL A 186
 None
EPE  A 502 (-3.9A)
None
None
 0.95A 1sn5A-2x4dA:
undetectable		 1sn5A-2x4dA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		4 LEU A  11
GLU A  54
LEU A  20
VAL A  31
 None
 0.95A 1sn5A-2yvlA:
undetectable		 1sn5A-2yvlA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywg GTP-BINDING PROTEIN
LEPA

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 LEU A 126
ALA A  96
LEU A  94
VAL A 257
 None
 1.16A 1sn5A-2ywgA:
undetectable		 1sn5A-2ywgA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 LEU A 213
ALA A 203
LEU A 201
VAL A 205
 None
 1.11A 1sn5A-2ztgA:
undetectable		 1sn5A-2ztgA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbj PUTATIVE
THIOESTERASE II

(Thermobifida
fusca) 		PF13622
(4HBT_3) 		4 LEU A 101
GLU A 218
LEU A  40
VAL A 198
 None
 1.12A 1sn5A-3bbjA:
undetectable		 1sn5A-3bbjA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Rhodospirillum
rubrum) 		PF00440
(TetR_N) 		4 LEU A 174
ALA A 106
LEU A 102
VAL A  68
 None
 1.01A 1sn5A-3cwrA:
undetectable		 1sn5A-3cwrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dto BH2835 PROTEIN

(Bacillus
halodurans) 		PF01966
(HD) 		4 LYS A  38
LEU A  35
GLU A  42
ALA A  37
 None
 1.12A 1sn5A-3dtoA:
undetectable		 1sn5A-3dtoA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		4 GLU A 122
ALA A 124
LEU A 433
VAL A 205
 None
 1.02A 1sn5A-3e1kA:
undetectable		 1sn5A-3e1kA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A  15
GLU A 224
ALA A  50
VAL A 238
 None
 1.19A 1sn5A-3e60A:
undetectable		 1sn5A-3e60A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 LYS A 495
ALA A 531
LEU A 529
VAL A 542
 None
 1.02A 1sn5A-3ecqA:
undetectable		 1sn5A-3ecqA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		4 LEU A 283
GLU A 127
ALA A 281
VAL A 297
 None
 1.18A 1sn5A-3f8tA:
undetectable		 1sn5A-3f8tA:
13.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		4 GLU A  54
ALA A 108
LEU A 110
VAL A 121
 None
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
 0.62A 1sn5A-3fc8A:
20.7		 1sn5A-3fc8A:
55.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		4 LEU A  17
ALA A 108
LEU A 110
VAL A 121
 IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
 0.53A 1sn5A-3fc8A:
20.7		 1sn5A-3fc8A:
55.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		4 LEU A 316
ALA A 365
LEU A 363
VAL A 367
 None
 1.19A 1sn5A-3i6dA:
undetectable		 1sn5A-3i6dA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3idu UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF07705
(CARDB) 		4 LYS A 463
LEU A 465
GLU A 496
VAL A 517
 None
 1.16A 1sn5A-3iduA:
4.0		 1sn5A-3iduA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
anthracis) 		PF00342
(PGI) 		4 LEU A 330
GLU A 269
ALA A 282
LEU A 278
 None
 0.93A 1sn5A-3ifsA:
undetectable		 1sn5A-3ifsA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilh TWO COMPONENT
RESPONSE REGULATOR

(Cytophaga
hutchinsonii) 		PF00072
(Response_reg) 		4 LYS A  48
LEU A  11
GLU A  51
ALA A  45
 None
 1.06A 1sn5A-3ilhA:
undetectable		 1sn5A-3ilhA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv9 TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF03466
(LysR_substrate) 		4 GLU A 252
ALA A 247
LEU A 245
VAL A 301
 None
 0.97A 1sn5A-3jv9A:
undetectable		 1sn5A-3jv9A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyj CHEY6 PROTEIN

(Rhodobacter
sphaeroides) 		PF00072
(Response_reg) 		4 LEU B  68
GLU B  98
ALA B 101
VAL B 104
 None
 1.02A 1sn5A-3kyjB:
undetectable		 1sn5A-3kyjB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7m 33 KDA CHAPERONIN

(Escherichia
coli) 		PF01430
(HSP33) 		4 LEU X 156
GLU X  49
LEU X 173
VAL X  26
 None
 1.19A 1sn5A-3m7mX:
undetectable		 1sn5A-3m7mX:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 LEU A 321
GLU A 303
ALA A 285
LEU A 283
 None
 0.98A 1sn5A-3oepA:
undetectable		 1sn5A-3oepA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 LYS A 138
LEU A 140
GLU A 150
LEU A 126
 None
 1.07A 1sn5A-3okyA:
undetectable		 1sn5A-3okyA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op6 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF04073
(tRNA_edit) 		4 LYS A  49
LEU A  54
GLU A  80
LEU A 108
 None
 1.17A 1sn5A-3op6A:
undetectable		 1sn5A-3op6A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qac 11S GLOBULIN SEED
STORAGE PROTEIN

(Amaranthus
hypochondriacus) 		PF00190
(Cupin_1) 		4 LEU A 318
ALA A 325
LEU A 323
VAL A 398
 None
 1.08A 1sn5A-3qacA:
undetectable		 1sn5A-3qacA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		4 LEU A 264
ALA A 260
LEU A 266
VAL A 248
 None
 0.83A 1sn5A-3si9A:
undetectable		 1sn5A-3si9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE

(Acetobacter
aceti) 		PF02515
(CoA_transf_3) 		4 LEU A 226
ALA A 222
LEU A 186
VAL A 217
 None
 0.93A 1sn5A-3ubmA:
undetectable		 1sn5A-3ubmA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urr PTS IIA-LIKE
NITROGEN-REGULATORY
PROTEIN PTSN

(Burkholderia
thailandensis) 		PF00359
(PTS_EIIA_2) 		4 LEU A 104
ALA A  79
LEU A  77
VAL A  81
 None
 1.08A 1sn5A-3urrA:
undetectable		 1sn5A-3urrA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		4 LEU A 213
ALA A 203
LEU A 201
VAL A 205
 None
 1.19A 1sn5A-3wqyA:
undetectable		 1sn5A-3wqyA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		4 LYS A 718
LEU A 720
GLU A 649
ALA A 740
 None
 1.18A 1sn5A-3wqyA:
undetectable		 1sn5A-3wqyA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzs UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		4 LYS A 754
GLU A 757
ALA A 750
VAL A 736
 None
 1.16A 1sn5A-3wzsA:
undetectable		 1sn5A-3wzsA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		4 LEU A 389
GLU A 385
LEU A 392
VAL A 189
 None
 1.18A 1sn5A-3zlbA:
undetectable		 1sn5A-3zlbA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		4 LYS A 171
LEU A   4
GLU A 170
VAL A  16
 None
 0.94A 1sn5A-3zlbA:
undetectable		 1sn5A-3zlbA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC

(Mycobacterium
tuberculosis) 		PF01583
(APS_kinase) 		4 LEU A 501
GLU A 528
ALA A 533
LEU A 504
 ADX  A1613 (-4.3A)
None
None
None
 1.16A 1sn5A-4bzxA:
undetectable		 1sn5A-4bzxA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Sinorhizobium
meliloti) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLU A  80
ALA A  86
LEU A  57
VAL A  88
 None
 1.19A 1sn5A-4dioA:
undetectable		 1sn5A-4dioA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6b ALLENE OXIDE CYCLASE

(Physcomitrella
patens) 		PF06351
(Allene_ox_cyc) 		4 LYS A 176
ALA A 175
LEU A  62
VAL A 183
 None
 1.20A 1sn5A-4h6bA:
undetectable		 1sn5A-4h6bA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kng E3 UBIQUITIN-PROTEIN
LIGASE RNF43

(Homo sapiens) 		no annotation 4 GLU E 131
ALA E 134
LEU E  99
VAL E 137
 None
 0.89A 1sn5A-4kngE:
undetectable		 1sn5A-4kngE:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		4 LYS A 504
GLU A 532
ALA A 470
VAL A 468
 None
 1.04A 1sn5A-4mr0A:
undetectable		 1sn5A-4mr0A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		4 LYS A  40
ALA A 120
LEU A 122
VAL A 118
 None
 1.10A 1sn5A-4pbxA:
3.5		 1sn5A-4pbxA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pde PROTEIN FDHD

(Escherichia
coli) 		PF02634
(FdhD-NarQ) 		4 LEU A 157
GLU A 187
ALA A 173
LEU A 215
 None
 1.10A 1sn5A-4pdeA:
undetectable		 1sn5A-4pdeA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus) 		PF00724
(Oxidored_FMN) 		4 LYS A 179
LEU A  94
ALA A 180
VAL A 188
 None
 1.10A 1sn5A-4tmcA:
undetectable		 1sn5A-4tmcA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLU S  29
ALA S  27
LEU S  25
VAL S 158
 None
 1.18A 1sn5A-4u9iS:
undetectable		 1sn5A-4u9iS:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uft NUCLEOPROTEIN

(Measles
morbillivirus) 		PF00973
(Paramyxo_ncap) 		4 LYS B 124
GLU B 124
ALA B 127
LEU B 114
 None
 1.02A 1sn5A-4uftB:
undetectable		 1sn5A-4uftB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhc ALPHA-L-RHAMNOSIDASE

(Klebsiella
oxytoca) 		PF17389
(Bac_rhamnosid6H) 		4 LYS A 347
LEU A 345
ALA A 350
VAL A 354
 None
 1.07A 1sn5A-4xhcA:
undetectable		 1sn5A-4xhcA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdh BETA CHAIN OF JKF6
T-CELL
RECEPTOR,PROTEIN
TRBV28

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS B  13
LEU B  11
GLU B  17
VAL B 119
 None
 1.17A 1sn5A-4zdhB:
undetectable		 1sn5A-4zdhB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aox SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN

(Homo sapiens) 		PF02290
(SRP14) 		4 GLU B  12
ALA B  60
LEU B  58
VAL B  26
 None
 0.78A 1sn5A-5aoxB:
undetectable		 1sn5A-5aoxB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqt PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRMBL2

(Pyrococcus
furiosus) 		PF01978
(TrmB)
PF11495
(Regulator_TrmB) 		4 LEU A 215
GLU A 220
LEU A 152
VAL A 174
 None
 0.84A 1sn5A-5bqtA:
undetectable		 1sn5A-5bqtA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 LEU A 434
GLU A 432
ALA A 429
LEU A 427
 None
 1.17A 1sn5A-5c3mA:
undetectable		 1sn5A-5c3mA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdn DNA GYRASE SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		4 LEU A 459
GLU A 462
LEU A 455
VAL A 469
 LEU  A 459 ( 0.6A)
GLU  A 462 ( 0.6A)
LEU  A 455 ( 0.6A)
VAL  A 469 ( 0.6A)
 1.19A 1sn5A-5cdnA:
undetectable		 1sn5A-5cdnA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwu NUCLEOPORIN NUP188

(Chaetomium
thermophilum) 		no annotation 4 LEU A1688
ALA A1704
LEU A1757
VAL A1772
 None
 1.14A 1sn5A-5cwuA:
undetectable		 1sn5A-5cwuA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2e BETA-LACTAMASE

(Yersinia
enterocolitica) 		PF13354
(Beta-lactamase2) 		4 GLU A 118
ALA A  56
LEU A  58
VAL A 125
 None
 1.19A 1sn5A-5e2eA:
undetectable		 1sn5A-5e2eA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec0 ALP7A

(Bacillus
subtilis) 		no annotation 4 LYS A 158
LEU A 160
GLU A 167
LEU A  57
 None
 0.74A 1sn5A-5ec0A:
undetectable		 1sn5A-5ec0A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 4 LEU A 650
GLU A 686
ALA A 688
LEU A 653
 None
 1.18A 1sn5A-5hdtA:
undetectable		 1sn5A-5hdtA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		4 LEU A 270
ALA A 234
LEU A 236
VAL A 203
 None
ERY  A 402 ( 3.2A)
None
None
 1.17A 1sn5A-5igpA:
undetectable		 1sn5A-5igpA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivx T-CELL RECEPTOR BETA
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS F  12
LEU F  10
GLU F  16
VAL F 116
 None
 1.11A 1sn5A-5ivxF:
undetectable		 1sn5A-5ivxF:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 LEU S 384
GLU S 379
LEU S 442
VAL S 370
 None
 0.82A 1sn5A-5k0yS:
undetectable		 1sn5A-5k0yS:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 LYS A 138
LEU A 140
GLU A 150
LEU A 126
 None
 1.17A 1sn5A-5l5gA:
undetectable		 1sn5A-5l5gA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		4 LYS A  41
LEU A  43
LEU A  85
VAL A  75
 None
 0.93A 1sn5A-5m09A:
undetectable		 1sn5A-5m09A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2y TSSK C

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		4 LEU A 334
GLU A 331
ALA A 421
LEU A 419
 None
 1.18A 1sn5A-5m2yA:
undetectable		 1sn5A-5m2yA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A  97
GLU A 135
ALA A 138
LEU A 100
 None
 0.86A 1sn5A-5mfbA:
undetectable		 1sn5A-5mfbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A 139
GLU A 177
ALA A 180
LEU A 142
 None
 0.89A 1sn5A-5mfbA:
undetectable		 1sn5A-5mfbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfd YIIIM''6AII

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A 265
GLU A 303
ALA A 306
LEU A 268
 None
 0.75A 1sn5A-5mfdA:
undetectable		 1sn5A-5mfdA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfo YIIIM3AIII

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A 139
GLU A 177
ALA A 180
LEU A 142
 None
 0.87A 1sn5A-5mfoA:
undetectable		 1sn5A-5mfoA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 LYS A 656
LEU A 658
LEU A 621
VAL A 630
 None
 1.17A 1sn5A-5n4lA:
undetectable		 1sn5A-5n4lA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE TLDD

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		4 LEU A 185
ALA A 157
LEU A 159
VAL A 155
 None
 1.04A 1sn5A-5njfA:
undetectable		 1sn5A-5njfA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 LEU A   3
ALA A   8
LEU A   6
VAL A  10
 None
 1.12A 1sn5A-5t2uA:
undetectable		 1sn5A-5t2uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		4 LYS A 180
LEU A 182
GLU A 213
LEU A 156
 None
 0.55A 1sn5A-5ujsA:
undetectable		 1sn5A-5ujsA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum) 		no annotation 4 LEU A 232
ALA A 260
LEU A 258
VAL A 262
 None
 1.19A 1sn5A-5v2dA:
undetectable		 1sn5A-5v2dA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viu ACETYLORNITHINE
AMINOTRANSFERASE

(Elizabethkingia
anophelis) 		PF00202
(Aminotran_3) 		4 GLU A  91
ALA A 272
LEU A 257
VAL A 270
 None
 1.13A 1sn5A-5viuA:
undetectable		 1sn5A-5viuA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 LYS C4070
GLU C4069
ALA C4073
LEU C3857
 None
 1.16A 1sn5A-5y3rC:
undetectable		 1sn5A-5y3rC:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE

(Homo sapiens) 		no annotation 4 LEU A 166
ALA A 169
LEU A 165
VAL A 158
 None
None
SAH  A 305 ( 4.6A)
None
 1.17A 1sn5A-6b92A:
undetectable		 1sn5A-6b92A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE

(Legionella
pneumophila) 		no annotation 4 LYS A  33
GLU A  28
LEU A   9
VAL A  90
 None
 1.00A 1sn5A-6eslA:
undetectable		 1sn5A-6eslA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fue FLAVODOXIN

(Helicobacter
pylori) 		PF00258
(Flavodoxin_1) 		4 LEU A  83
THR A  54
ALA A  52
LEU A  50
 None
FMN  A 165 (-4.0A)
None
None
 0.98A 1sn5C-1fueA:
undetectable		 1sn5C-1fueA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 LEU A 385
GLU A 375
THR A 341
ALA A 397
 None
 0.93A 1sn5C-1g7cA:
undetectable		 1sn5C-1g7cA:
16.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		7 LYS A  15
LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
VAL A 121
 None
 0.66A 1sn5C-1gkeA:
19.6		 1sn5C-1gkeA:
56.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9y FEZ-1 B-LACTAMASE

(Fluoribacter
gormanii) 		PF00753
(Lactamase_B) 		4 MET A 205
ALA A 189
LEU A 191
VAL A 180
 None
None
None
GOL  A 600 (-3.7A)
 0.70A 1sn5C-1l9yA:
undetectable		 1sn5C-1l9yA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md7 C1R COMPLEMENT
SERINE PROTEASE

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 LYS A 382
THR A 380
ALA A 383
VAL A 378
 None
 0.85A 1sn5C-1md7A:
undetectable		 1sn5C-1md7A:
14.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		8 MET A  13
LYS A  15
LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
VAL A 121
 None
 0.19A 1sn5C-1sn2A:
23.0		 1sn5C-1sn2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		8 MET A  13
LYS A  15
LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
VAL A 121
 None
 0.42A 1sn5C-1tfpA:
18.4		 1sn5C-1tfpA:
62.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x05 PLECKSTRIN

(Homo sapiens) 		PF00169
(PH) 		4 GLU A 110
THR A 104
ALA A 102
LEU A 100
 None
 0.92A 1sn5C-1x05A:
0.0		 1sn5C-1x05A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 LEU A 281
THR A 272
LEU A 276
VAL A 220
 None
 0.68A 1sn5C-1y8pA:
0.6		 1sn5C-1y8pA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Pyrococcus
furiosus) 		PF01380
(SIS) 		4 LEU A 193
GLU A 218
THR A 237
LEU A 241
 None
 0.63A 1sn5C-2cb0A:
undetectable		 1sn5C-2cb0A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		4 GLU A 102
ALA A  85
LEU A  23
VAL A 321
 None
 0.93A 1sn5C-2dwcA:
undetectable		 1sn5C-2dwcA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510

(Pyrococcus
horikoshii) 		PF01380
(SIS) 		4 LEU A 193
GLU A 218
THR A 237
LEU A 241
 None
 0.65A 1sn5C-2e5fA:
undetectable		 1sn5C-2e5fA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4u THIOESTERASE
SUPERFAMILY MEMBER 2

(Homo sapiens) 		PF03061
(4HBT) 		4 LYS A 136
THR A 116
ALA A 114
VAL A 106
 None
 0.87A 1sn5C-2h4uA:
undetectable		 1sn5C-2h4uA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hls PROTEIN DISULFIDE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF13192
(Thioredoxin_3) 		4 GLU A 178
THR A  89
ALA A  91
LEU A  93
 None
 0.93A 1sn5C-2hlsA:
undetectable		 1sn5C-2hlsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5c PLECKSTRIN

(Homo sapiens) 		PF00169
(PH) 		4 GLU A 337
THR A 331
ALA A 329
LEU A 327
 None
 0.88A 1sn5C-2i5cA:
undetectable		 1sn5C-2i5cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2

(Saccharomyces
cerevisiae) 		PF03095
(PTPA) 		4 LEU A 202
GLU A  34
THR A 209
ALA A 205
 None
 0.79A 1sn5C-2ixnA:
undetectable		 1sn5C-2ixnA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxs TIGHT JUNCTION
PROTEIN ZO-1,
LINKER, PEPTIDE OF
MYOCARDIUM-ENRICHED
ZO-ASSOCIATED
PROTEIN

(Homo sapiens;
synthetic
construct) 		PF00791
(ZU5) 		4 LEU A  77
THR A  36
LEU A  78
VAL A  38
 None
 0.96A 1sn5C-2kxsA:
undetectable		 1sn5C-2kxsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4q THIOREDOXIN

(Mycobacterium
tuberculosis) 		PF00085
(Thioredoxin) 		4 THR A  59
ALA A  61
LEU A  63
VAL A  28
 None
 0.94A 1sn5C-2l4qA:
undetectable		 1sn5C-2l4qA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p23 FIBROBLAST GROWTH
FACTOR 19

(Homo sapiens) 		PF00167
(FGF) 		4 GLU A 137
THR A  89
ALA A 121
VAL A  85
 None
 0.89A 1sn5C-2p23A:
undetectable		 1sn5C-2p23A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7n LEUKEMIA INHIBITORY
FACTOR RECEPTOR

(Mus musculus) 		PF00041
(fn3) 		4 LEU A  79
GLU A  81
THR A  12
LEU A   8
 None
 0.93A 1sn5C-2q7nA:
undetectable		 1sn5C-2q7nA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU B 363
THR B 415
ALA B 391
LEU B 367
 None
 0.96A 1sn5C-2v9tB:
undetectable		 1sn5C-2v9tB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		4 LYS A 397
ALA A 416
LEU A 418
VAL A 414
 None
 1.01A 1sn5C-2wn4A:
undetectable		 1sn5C-2wn4A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE

(Homo sapiens) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 LYS A 183
ALA A 184
LEU A 176
VAL A 186
 None
EPE  A 502 (-3.9A)
None
None
 0.97A 1sn5C-2x4dA:
undetectable		 1sn5C-2x4dA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		4 LEU A 367
THR A  61
ALA A  65
LEU A  69
 None
 0.99A 1sn5C-2x98A:
undetectable		 1sn5C-2x98A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 MET A 666
THR A 665
ALA A 663
LEU A  67
 None
 0.90A 1sn5C-2xsgA:
undetectable		 1sn5C-2xsgA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywj GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Methanocaldococcus
jannaschii) 		PF01174
(SNO) 		4 LEU A  92
THR A  85
LEU A  94
VAL A  99
 None
 0.93A 1sn5C-2ywjA:
undetectable		 1sn5C-2ywjA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Rhodospirillum
rubrum) 		PF00440
(TetR_N) 		4 LEU A 174
ALA A 106
LEU A 102
VAL A  68
 None
 0.98A 1sn5C-3cwrA:
undetectable		 1sn5C-3cwrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		4 GLU A 122
ALA A 124
LEU A 433
VAL A 205
 None
 1.01A 1sn5C-3e1kA:
undetectable		 1sn5C-3e1kA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 LYS A 495
ALA A 531
LEU A 529
VAL A 542
 None
 0.99A 1sn5C-3ecqA:
undetectable		 1sn5C-3ecqA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5o THIOESTERASE
SUPERFAMILY MEMBER 2

(Homo sapiens) 		PF03061
(4HBT) 		4 LYS A 136
THR A 116
ALA A 114
VAL A 106
 UOC  A 149 (-3.1A)
None
None
None
 0.89A 1sn5C-3f5oA:
undetectable		 1sn5C-3f5oA:
24.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		6 LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
VAL A 121
 IFA  A3000 ( 4.7A)
None
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
 0.68A 1sn5C-3fc8A:
20.5		 1sn5C-3fc8A:
55.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
GLU A  54
THR A 106
LEU A 110
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-4.9A)
IFA  A3000 (-4.1A)
 1.05A 1sn5C-3fc8A:
20.5		 1sn5C-3fc8A:
55.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
anthracis) 		PF00342
(PGI) 		4 LEU A 330
GLU A 269
ALA A 282
LEU A 278
 None
 0.96A 1sn5C-3ifsA:
undetectable		 1sn5C-3ifsA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihu TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Cupriavidus
pinatubonensis) 		PF00392
(GntR)
PF07729
(FCD) 		4 LEU A 156
THR A 105
LEU A 148
VAL A 192
 None
 1.00A 1sn5C-3ihuA:
undetectable		 1sn5C-3ihuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv9 TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF03466
(LysR_substrate) 		4 GLU A 252
ALA A 247
LEU A 245
VAL A 301
 None
 0.98A 1sn5C-3jv9A:
undetectable		 1sn5C-3jv9A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Lactobacillus
brevis) 		PF13407
(Peripla_BP_4) 		4 THR A 243
ALA A 245
LEU A 189
VAL A 271
 None
 0.95A 1sn5C-3jy6A:
undetectable		 1sn5C-3jy6A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		4 LEU D  53
GLU D  62
ALA D  38
LEU D  42
 None
 0.88A 1sn5C-3k70D:
undetectable		 1sn5C-3k70D:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv3 COATOMER SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF06957
(COPI_C) 		4 GLU A 900
ALA A 916
LEU A 914
VAL A 984
 None
 0.95A 1sn5C-3mv3A:
undetectable		 1sn5C-3mv3A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 LEU A 321
GLU A 303
ALA A 285
LEU A 283
 None
 0.98A 1sn5C-3oepA:
undetectable		 1sn5C-3oepA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		4 MET A 339
THR A 317
ALA A 319
VAL A 282
 None
 0.78A 1sn5C-3qfwA:
undetectable		 1sn5C-3qfwA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvd RUBRERYTHRIN

(Pyrococcus
furiosus) 		PF02915
(Rubrerythrin) 		4 THR A  81
ALA A 118
LEU A 120
VAL A  84
 None
 0.89A 1sn5C-3qvdA:
undetectable		 1sn5C-3qvdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		4 LEU A 264
ALA A 260
LEU A 266
VAL A 248
 None
 0.86A 1sn5C-3si9A:
undetectable		 1sn5C-3si9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty1 HYPOTHETICAL ALDOSE
1-EPIMERASE

(Klebsiella
pneumoniae) 		PF14486
(DUF4432) 		4 LEU A 210
THR A 195
LEU A 199
VAL A 183
 None
 0.82A 1sn5C-3ty1A:
undetectable		 1sn5C-3ty1A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9p NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Mus musculus) 		PF00061
(Lipocalin) 		4 LEU C 140
THR C 132
LEU C 144
VAL C 117
 None
 0.93A 1sn5C-3u9pC:
undetectable		 1sn5C-3u9pC:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE

(Acetobacter
aceti) 		PF02515
(CoA_transf_3) 		4 LEU A 226
ALA A 222
LEU A 186
VAL A 217
 None
 0.98A 1sn5C-3ubmA:
undetectable		 1sn5C-3ubmA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxf FIMBRIAL SUBUNIT
TYPE 1

(Actinomyces
oris) 		no annotation 4 GLU A 145
THR A 123
ALA A 129
LEU A  48
 None
 0.94A 1sn5C-3uxfA:
6.5		 1sn5C-3uxfA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		4 MET A  11
THR A  39
ALA A  37
VAL A  75
 None
 0.82A 1sn5C-3vocA:
undetectable		 1sn5C-3vocA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09754
(PAC2) 		4 LEU A 194
GLU A 134
THR A 132
VAL A 127
 None
 0.96A 1sn5C-3vr0A:
undetectable		 1sn5C-3vr0A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfe CELL SURFACE
GLYCOPROTEIN CD200
RECEPTOR 4

(Mus musculus) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 LEU A  45
GLU A 106
THR A  59
ALA A  61
 None
 0.73A 1sn5C-4bfeA:
3.0		 1sn5C-4bfeA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C

(Escherichia
coli) 		PF01464
(SLT)
PF11873
(DUF3393) 		4 LEU A 277
THR A 240
LEU A 274
VAL A 237
 None
 0.99A 1sn5C-4c5fA:
undetectable		 1sn5C-4c5fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 GLU A 806
THR A 711
LEU A 770
VAL A 712
 None
 1.01A 1sn5C-4crsA:
undetectable		 1sn5C-4crsA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es1 BH0342 PROTEIN

(Bacillus
halodurans) 		PF09827
(CRISPR_Cas2) 		4 LEU A  71
THR A   6
LEU A   2
VAL A  38
 None
 0.78A 1sn5C-4es1A:
undetectable		 1sn5C-4es1A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING

(Polaromonas sp.
JS666) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 THR A  76
ALA A  78
LEU A  80
VAL A  53
 None
 0.60A 1sn5C-4g2nA:
undetectable		 1sn5C-4g2nA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh7 NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A 144
THR A 136
LEU A 148
VAL A 121
 None
 0.96A 1sn5C-4gh7A:
undetectable		 1sn5C-4gh7A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 LEU A 195
GLU A 230
THR A 237
VAL A 252
 None
 0.97A 1sn5C-4hkmA:
undetectable		 1sn5C-4hkmA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX

(Pseudomonas
aeruginosa) 		no annotation 4 LEU B 107
THR B 192
LEU B 320
VAL B 189
 None
 0.85A 1sn5C-4kncB:
undetectable		 1sn5C-4kncB:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kng E3 UBIQUITIN-PROTEIN
LIGASE RNF43

(Homo sapiens) 		no annotation 4 GLU E 131
ALA E 134
LEU E  99
VAL E 137
 None
 0.86A 1sn5C-4kngE:
undetectable		 1sn5C-4kngE:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A 645
GLU A 653
THR A 465
VAL A 627
 None
 0.59A 1sn5C-4mycA:
undetectable		 1sn5C-4mycA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		4 GLU A 391
THR A 136
ALA A 138
VAL A 164
 None
 0.93A 1sn5C-4n0rA:
2.9		 1sn5C-4n0rA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0e MAF-LIKE PROTEIN
YHDE

(Escherichia
coli) 		PF02545
(Maf) 		4 LEU A  67
THR A 105
LEU A 109
VAL A 120
 None
 0.81A 1sn5C-4p0eA:
undetectable		 1sn5C-4p0eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00118
(Cpn60_TCP1) 		4 LEU A 370
THR A 296
LEU A 373
VAL A 321
 None
 0.73A 1sn5C-4pj1A:
undetectable		 1sn5C-4pj1A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5w MATERNAL PROTEIN
TUDOR

(Drosophila
melanogaster) 		PF00567
(TUDOR) 		4 GLU A2000
THR A1981
ALA A1983
VAL A2119
 EPE  A2201 (-3.5A)
EPE  A2201 (-2.8A)
None
None
 0.68A 1sn5C-4q5wA:
undetectable		 1sn5C-4q5wA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A 144
THR A 136
LEU A 148
VAL A 121
 None
 0.95A 1sn5C-4qaeA:
undetectable		 1sn5C-4qaeA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 325
THR A 304
LEU A 308
VAL A 281
 None
 0.58A 1sn5C-4rjkA:
undetectable		 1sn5C-4rjkA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7v NUCLEOTIDYL
TRANSFERASE

(Pseudomonas
putida) 		PF00483
(NTP_transferase) 		4 LEU A  41
THR A 110
LEU A  38
VAL A 108
 None
 0.95A 1sn5C-4y7vA:
undetectable		 1sn5C-4y7vA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 LYS A 495
ALA A 531
LEU A 529
VAL A 542
 None
 0.95A 1sn5C-5a55A:
undetectable		 1sn5C-5a55A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d INSCUTEABLE

(Drosophila
melanogaster) 		no annotation 4 MET L 499
LEU L 587
ALA L 541
LEU L 539
 None
 0.72A 1sn5C-5a7dL:
undetectable		 1sn5C-5a7dL:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 GLU A 804
THR A 808
ALA A 860
LEU A 858
 GOL  A2163 (-3.5A)
None
None
None
 0.94A 1sn5C-5aorA:
undetectable		 1sn5C-5aorA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aox SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN

(Homo sapiens) 		PF02290
(SRP14) 		4 GLU B  12
ALA B  60
LEU B  58
VAL B  26
 None
 0.76A 1sn5C-5aoxB:
undetectable		 1sn5C-5aoxB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqt PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRMBL2

(Pyrococcus
furiosus) 		PF01978
(TrmB)
PF11495
(Regulator_TrmB) 		4 LEU A 215
GLU A 220
LEU A 152
VAL A 174
 None
 0.86A 1sn5C-5bqtA:
undetectable		 1sn5C-5bqtA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb6 PROBABLE
ADENYLYL-SULFATE
KINASE

(Synechocystis
sp. PCC 6803) 		PF01583
(APS_kinase) 		4 LEU A  72
THR A  98
LEU A  73
VAL A  95
 None
 0.80A 1sn5C-5cb6A:
undetectable		 1sn5C-5cb6A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhg SOLUBLE CYTOCHROME
B562,NOCICEPTIN
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1) 		4 LEU A 322
GLU A 324
ALA A 320
LEU A 318
 None
 0.96A 1sn5C-5dhgA:
undetectable		 1sn5C-5dhgA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 MET A 557
LEU A 315
ALA A 302
VAL A 568
 TRS  A1001 (-3.5A)
None
None
None
 0.76A 1sn5C-5dkxA:
undetectable		 1sn5C-5dkxA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		4 MET A 151
ALA A  56
LEU A  50
VAL A  99
 None
 0.96A 1sn5C-5e3cA:
undetectable		 1sn5C-5e3cA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec0 ALP7A

(Bacillus
subtilis) 		no annotation 4 LYS A 158
LEU A 160
GLU A 167
LEU A  57
 None
 0.79A 1sn5C-5ec0A:
undetectable		 1sn5C-5ec0A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 LEU A  69
THR A  79
LEU A  83
VAL A 285
 None
 0.90A 1sn5C-5f7cA:
undetectable		 1sn5C-5f7cA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 THR A 995
ALA A 997
LEU A 999
VAL A1050
 None
 0.69A 1sn5C-5fkuA:
undetectable		 1sn5C-5fkuA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6b PUTATIVE SECRETED
LIPASE

(Streptomyces
sp. W007) 		PF01674
(Lipase_2) 		4 LEU A 224
THR A 193
LEU A 221
VAL A 132
 None
 0.77A 1sn5C-5h6bA:
undetectable		 1sn5C-5h6bA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibo OPLOPHORUS-LUCIFERIN
2-MONOOXYGENASE
CATALYTIC SUBUNIT

(Oplophorus
gracilirostris) 		no annotation 4 LEU A 150
GLU A 140
THR A 159
LEU A 163
 None
 0.97A 1sn5C-5iboA:
undetectable		 1sn5C-5iboA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it9 RIBOSOMAL PROTEIN
RACK1

(Kluyveromyces
lactis) 		PF01092
(Ribosomal_S6e) 		4 GLU g 280
THR g 263
ALA g 261
VAL g 247
 None
 0.89A 1sn5C-5it9g:
undetectable		 1sn5C-5it9g:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 LEU S 384
GLU S 379
LEU S 442
VAL S 370
 None
 0.83A 1sn5C-5k0yS:
undetectable		 1sn5C-5k0yS:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A 144
THR A 136
LEU A 148
VAL A 121
 None
 0.92A 1sn5C-5khpA:
undetectable		 1sn5C-5khpA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A  97
GLU A 135
ALA A 138
LEU A 100
 None
 0.87A 1sn5C-5mfbA:
undetectable		 1sn5C-5mfbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A 139
GLU A 177
ALA A 180
LEU A 142
 None
 0.90A 1sn5C-5mfbA:
undetectable		 1sn5C-5mfbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n48 NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		no annotation 4 LEU A 144
THR A 136
LEU A 148
VAL A 121
 None
 0.90A 1sn5C-5n48A:
undetectable		 1sn5C-5n48A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7

(Homo sapiens) 		no annotation 4 MET A 101
GLU A 104
THR A 215
VAL A 227
 None
 0.83A 1sn5C-5nfnA:
undetectable		 1sn5C-5nfnA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkn NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		no annotation 4 LEU A 144
THR A 136
LEU A 148
VAL A 121
 None
LOC  A 201 (-3.5A)
None
None
 0.93A 1sn5C-5nknA:
undetectable		 1sn5C-5nknA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Burkholderia
vietnamiensis) 		PF00982
(Glyco_transf_20) 		4 THR A  63
ALA A  65
LEU A  67
VAL A  38
 None
 0.67A 1sn5C-5tvgA:
undetectable		 1sn5C-5tvgA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Desulfovibrio
vulgaris) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 109
ALA A 258
LEU A 281
VAL A 246
 None
 0.98A 1sn5C-5tx7A:
undetectable		 1sn5C-5tx7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		4 LYS A 180
LEU A 182
GLU A 213
LEU A 156
 None
 0.69A 1sn5C-5ujsA:
undetectable		 1sn5C-5ujsA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unq PUTATIVE TAUTOMERASE

(Pusillimonas
sp. T7-7) 		no annotation 4 MET A  41
LEU A  45
THR A   4
VAL A  64
 None
 0.87A 1sn5C-5unqA:
undetectable		 1sn5C-5unqA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4s TRANSPORTER, CATION
CHANNEL FAMILY /
CYCLIC
NUCLEOTIDE-BINDING
DOMAIN MULTI-DOMAIN
PROTEIN

(Leptospira
licerasiae) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans) 		4 THR A 190
ALA A 160
LEU A 158
VAL A 191
 None
 0.99A 1sn5C-5v4sA:
undetectable		 1sn5C-5v4sA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		4 MET O1294
LEU O1099
GLU O1293
LEU O1096
 None
 0.96A 1sn5C-5x0yO:
undetectable		 1sn5C-5x0yO:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 5 MET A2540
THR A2539
ALA A2535
LEU A2531
VAL A2463
 None
 1.41A 1sn5C-5yz0A:
undetectable		 1sn5C-5yz0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4o GLUTATHIONE
REDUCTASE

(Enterococcus
faecalis) 		no annotation 4 MET A 222
THR A 192
ALA A 190
VAL A 169
 None
 0.54A 1sn5C-6b4oA:
undetectable		 1sn5C-6b4oA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvg PROTEIN-N(PI)-PHOSPH
OHISTIDINE-SUGAR
PHOSPHOTRANSFERASE
(ENZYME II OF THE
PHOSPHOTRANSFERASE
SYSTEM) (PTS SYSTEM
GLUCOSE-SPECIFIC
IIBC COMPONENT)

(Bacillus cereus) 		no annotation 4 THR A 149
ALA A  69
LEU A  67
VAL A 145
 None
 0.97A 1sn5C-6bvgA:
undetectable		 1sn5C-6bvgA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Lactobacillus
paracasei) 		no annotation 4 LEU A 323
THR A 154
LEU A 158
VAL A 142
 None
None
CL  A 403 (-4.6A)
None
 0.95A 1sn5C-6chkA:
undetectable		 1sn5C-6chkA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 GLU A1165
THR A1125
ALA A1123
VAL A1100
 None
 0.85A 1sn5C-6f9nA:
undetectable		 1sn5C-6f9nA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftx -

(-) 		no annotation 4 MET W 815
LEU W 819
THR W 785
VAL W 714
 None
 0.62A 1sn5C-6ftxW:
undetectable		 1sn5C-6ftxW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gqz -

(-) 		no annotation 4 LEU A 144
THR A 136
LEU A 148
VAL A 121
 None
 0.95A 1sn5C-6gqzA:
undetectable		 1sn5C-6gqzA:
undetectable