SIMILAR PATTERNS OF AMINO ACIDS FOR 1SN0_B_T44B602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLU A 299
ALA A 325
LYS A 292
ALA A 290
 None
 1.11A 1sn0B-1e5mA:
0.0
1sn0D-1e5mA:
0.0		 1sn0B-1e5mA:
18.10
1sn0D-1e5mA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		4 ALA A 103
LYS B 103
LEU B  99
ALA B 102
 None
 1.14A 1sn0B-1efpA:
0.0
1sn0D-1efpA:
undetectable		 1sn0B-1efpA:
17.43
1sn0D-1efpA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek6 UDP-GALACTOSE
4-EPIMERASE

(Homo sapiens) 		PF16363
(GDP_Man_Dehyd) 		4 LYS A 257
GLU A 260
ALA A 254
ALA A 314
 TMA  A 950 (-3.5A)
TMA  A 950 (-3.8A)
None
None
 1.11A 1sn0B-1ek6A:
0.0
1sn0D-1ek6A:
0.0		 1sn0B-1ek6A:
14.94
1sn0D-1ek6A:
14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
GLU A  54
ALA A 108
 None
 0.51A 1sn0B-1gkeA:
20.2
1sn0D-1gkeA:
19.9		 1sn0B-1gkeA:
56.92
1sn0D-1gkeA:
56.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h21 SPLIT-SORET
CYTOCHROME C

(Desulfovibrio
desulfuricans) 		PF09719
(C_GCAxxG_C_C) 		4 LYS A 181
GLU A 184
ALA A 178
LEU A 121
 None
 1.10A 1sn0B-1h21A:
undetectable
1sn0D-1h21A:
undetectable		 1sn0B-1h21A:
21.03
1sn0D-1h21A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0v TRNA-INTRON
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		4 LEU A 298
LYS A 110
LEU A  94
ALA A 111
 None
 1.02A 1sn0B-1r0vA:
undetectable
1sn0D-1r0vA:
0.3		 1sn0B-1r0vA:
16.56
1sn0D-1r0vA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0v TRNA-INTRON
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		4 LYS A 110
LEU A  94
ALA A 111
LEU A 298
 None
 1.03A 1sn0B-1r0vA:
undetectable
1sn0D-1r0vA:
0.3		 1sn0B-1r0vA:
16.56
1sn0D-1r0vA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkj NUCLEOLIN

(Mesocricetus
auratus) 		PF00076
(RRM_1) 		4 LEU A 102
ALA A 104
LEU A 116
ALA A 123
 None
 0.85A 1sn0B-1rkjA:
0.0
1sn0D-1rkjA:
0.0		 1sn0B-1rkjA:
21.67
1sn0D-1rkjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkj NUCLEOLIN

(Mesocricetus
auratus) 		PF00076
(RRM_1) 		4 LEU A 116
ALA A 123
LEU A 102
ALA A 104
 None
 0.84A 1sn0B-1rkjA:
0.0
1sn0D-1rkjA:
0.0		 1sn0B-1rkjA:
21.67
1sn0D-1rkjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		4 LYS A 124
GLU A 127
ALA A 121
LEU A 428
 None
 0.98A 1sn0B-1sjpA:
undetectable
1sn0D-1sjpA:
undetectable		 1sn0B-1sjpA:
14.03
1sn0D-1sjpA:
14.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
GLU A  54
ALA A 108
 None
 0.08A 1sn0B-1sn2A:
23.9
1sn0D-1sn2A:
23.6		 1sn0B-1sn2A:
100.00
1sn0D-1sn2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
GLU A  54
ALA A 108
 None
 0.23A 1sn0B-1tfpA:
18.8
1sn0D-1tfpA:
19.0		 1sn0B-1tfpA:
62.31
1sn0D-1tfpA:
62.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 LYS A 588
LEU A 585
GLU A 592
ALA A 404
 None
 0.99A 1sn0B-1u1hA:
undetectable
1sn0D-1u1hA:
undetectable		 1sn0B-1u1hA:
10.95
1sn0D-1u1hA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 LEU A  43
GLU A 265
ALA A 270
ALA A 220
 None
 0.96A 1sn0B-1v2dA:
undetectable
1sn0D-1v2dA:
undetectable		 1sn0B-1v2dA:
18.53
1sn0D-1v2dA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		4 LEU A 120
GLU A 145
LEU A  78
ALA A  81
 None
 1.06A 1sn0B-1vcgA:
undetectable
1sn0D-1vcgA:
undetectable		 1sn0B-1vcgA:
19.09
1sn0D-1vcgA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		4 LYS A  82
ALA A  83
LEU A   9
ALA A  11
 None
None
C  A1373 (-3.9A)
C  A1373 (-3.5A)
 1.10A 1sn0B-1w55A:
undetectable
1sn0D-1w55A:
undetectable		 1sn0B-1w55A:
16.53
1sn0D-1w55A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LYS A  82
GLU A  86
ALA A  46
LEU A  99
 None
 1.13A 1sn0B-2e5vA:
undetectable
1sn0D-2e5vA:
undetectable		 1sn0B-2e5vA:
18.56
1sn0D-2e5vA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA

(Synechocystis
sp.) 		PF13379
(NMT1_2) 		4 LEU A 289
GLU A 398
ALA A 400
ALA A 148
 None
 0.98A 1sn0B-2g29A:
undetectable
1sn0D-2g29A:
undetectable		 1sn0B-2g29A:
17.18
1sn0D-2g29A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2

(Salmonella
enterica) 		PF04166
(PdxA) 		4 GLU A  79
ALA A 100
LEU A 129
ALA A 132
 None
 1.09A 1sn0B-2hi1A:
undetectable
1sn0D-2hi1A:
undetectable		 1sn0B-2hi1A:
19.94
1sn0D-2hi1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5c 1,8-CINEOLE SYNTHASE

(Salvia
fruticosa) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LYS A  96
GLU A 127
LEU A 272
ALA A  89
 None
 1.10A 1sn0B-2j5cA:
undetectable
1sn0D-2j5cA:
undetectable		 1sn0B-2j5cA:
12.27
1sn0D-2j5cA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0z UNCHARACTERIZED
PROTEIN HP1203

(Helicobacter
pylori) 		PF00581
(Rhodanese) 		4 ALA A   6
LYS A  74
LEU A  70
ALA A  73
 None
 0.92A 1sn0B-2k0zA:
undetectable
1sn0D-2k0zA:
undetectable		 1sn0B-2k0zA:
18.84
1sn0D-2k0zA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0z UNCHARACTERIZED
PROTEIN HP1203

(Helicobacter
pylori) 		PF00581
(Rhodanese) 		4 LYS A  74
LEU A  70
ALA A  73
ALA A   6
 None
 0.97A 1sn0B-2k0zA:
undetectable
1sn0D-2k0zA:
undetectable		 1sn0B-2k0zA:
18.84
1sn0D-2k0zA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m89 AHA1 DOMAIN PROTEIN

(Colwellia
psychrerythraea) 		PF08327
(AHSA1) 		4 LYS A  16
ALA A  20
LEU A 125
ALA A 128
 None
 1.12A 1sn0B-2m89A:
undetectable
1sn0D-2m89A:
undetectable		 1sn0B-2m89A:
23.93
1sn0D-2m89A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rno PUTATIVE DNA-BINDING
PROTEIN

(Oryza sativa) 		PF02037
(SAP) 		4 LYS A   9
LEU A  43
LYS A  35
LEU A  20
 None
 1.16A 1sn0B-2rnoA:
undetectable
1sn0D-2rnoA:
undetectable		 1sn0B-2rnoA:
18.94
1sn0D-2rnoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rrk CTP
PYROPHOSPHOHYDROLASE

(Escherichia
coli) 		PF00293
(NUDIX) 		4 LEU A  62
GLU A  57
ALA A  14
ALA A  25
 None
 0.95A 1sn0B-2rrkA:
undetectable
1sn0D-2rrkA:
undetectable		 1sn0B-2rrkA:
22.73
1sn0D-2rrkA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 LEU A 486
GLU A  45
ALA A  85
ALA A  55
 None
 1.15A 1sn0B-2vpwA:
undetectable
1sn0D-2vpwA:
undetectable		 1sn0B-2vpwA:
9.71
1sn0D-2vpwA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 604
ALA A 648
LEU A 681
ALA A 512
 None
 1.02A 1sn0B-2wntA:
undetectable
1sn0D-2wntA:
undetectable		 1sn0B-2wntA:
17.93
1sn0D-2wntA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 681
ALA A 512
LEU A 604
ALA A 648
 None
 1.02A 1sn0B-2wntA:
undetectable
1sn0D-2wntA:
undetectable		 1sn0B-2wntA:
17.93
1sn0D-2wntA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU A 207
GLU A 248
LYS A 183
LEU A 180
 None
 1.07A 1sn0B-2zufA:
undetectable
1sn0D-2zufA:
undetectable		 1sn0B-2zufA:
11.82
1sn0D-2zufA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		4 LEU A 249
ALA A 361
LEU A 266
ALA A 269
 None
 1.02A 1sn0B-3bujA:
undetectable
1sn0D-3bujA:
undetectable		 1sn0B-3bujA:
16.99
1sn0D-3bujA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czc RMPB

(Streptococcus
mutans) 		PF02302
(PTS_IIB) 		4 LEU A  72
ALA A  56
LYS A  45
ALA A  48
 None
 1.08A 1sn0B-3czcA:
undetectable
1sn0D-3czcA:
undetectable		 1sn0B-3czcA:
21.05
1sn0D-3czcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czc RMPB

(Streptococcus
mutans) 		PF02302
(PTS_IIB) 		4 LYS A  45
ALA A  48
LEU A  72
ALA A  56
 None
 1.07A 1sn0B-3czcA:
undetectable
1sn0D-3czcA:
undetectable		 1sn0B-3czcA:
21.05
1sn0D-3czcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dte IRRE PROTEIN

(Deinococcus
deserti) 		PF06114
(Peptidase_M78) 		4 GLU A 113
LYS A  15
LEU A  11
ALA A  14
 None
 1.08A 1sn0B-3dteA:
undetectable
1sn0D-3dteA:
undetectable		 1sn0B-3dteA:
20.87
1sn0D-3dteA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dto BH2835 PROTEIN

(Bacillus
halodurans) 		PF01966
(HD) 		4 LYS A  38
LEU A  35
GLU A  42
ALA A  37
 None
 1.11A 1sn0B-3dtoA:
undetectable
1sn0D-3dtoA:
undetectable		 1sn0B-3dtoA:
20.18
1sn0D-3dtoA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 LEU A 432
GLU A 383
ALA A 456
ALA A 451
 None
 0.78A 1sn0B-3e1sA:
undetectable
1sn0D-3e1sA:
undetectable		 1sn0B-3e1sA:
12.15
1sn0D-3e1sA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		4 LYS A  69
ALA A  67
LEU A 132
ALA A 173
 None
 1.07A 1sn0B-3g5iA:
undetectable
1sn0D-3g5iA:
undetectable		 1sn0B-3g5iA:
23.60
1sn0D-3g5iA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF09334
(tRNA-synt_1g) 		4 LEU A 487
GLU A 443
LEU A 417
ALA A 451
 None
 0.96A 1sn0B-3h9cA:
undetectable
1sn0D-3h9cA:
undetectable		 1sn0B-3h9cA:
15.80
1sn0D-3h9cA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3idu UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF07705
(CARDB) 		4 LYS A 463
LEU A 465
GLU A 496
LYS A 427
 None
 0.98A 1sn0B-3iduA:
undetectable
1sn0D-3iduA:
4.0		 1sn0B-3iduA:
24.65
1sn0D-3iduA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 LEU A 406
GLU A  11
ALA A 423
LEU A 184
 None
 0.84A 1sn0B-3ie1A:
undetectable
1sn0D-3ie1A:
undetectable		 1sn0B-3ie1A:
15.58
1sn0D-3ie1A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 LEU A 333
GLU A 347
ALA A 329
ALA A 323
 None
None
SF4  A 801 ( 4.2A)
FMN  A 802 (-3.8A)
 0.84A 1sn0B-3k30A:
undetectable
1sn0D-3k30A:
undetectable		 1sn0B-3k30A:
10.83
1sn0D-3k30A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		4 LYS A1015
GLU A1019
ALA A1014
ALA A 815
 None
 1.09A 1sn0B-3mp6A:
undetectable
1sn0D-3mp6A:
undetectable		 1sn0B-3mp6A:
16.04
1sn0D-3mp6A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf4 ACYL-COA
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LYS A 160
GLU A 133
ALA A 216
LEU A 197
 None
 1.02A 1sn0B-3nf4A:
undetectable
1sn0D-3nf4A:
undetectable		 1sn0B-3nf4A:
16.20
1sn0D-3nf4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nku DRRA

(Legionella
pneumophila) 		no annotation 4 LYS A  36
GLU A  39
ALA A  33
ALA A  83
 None
 1.00A 1sn0B-3nkuA:
undetectable
1sn0D-3nkuA:
undetectable		 1sn0B-3nkuA:
21.72
1sn0D-3nkuA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obw PROTEIN PELOTA
HOMOLOG

(Sulfolobus
solfataricus) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		4 LEU A 286
GLU A 315
LYS A 254
ALA A 255
 None
 1.10A 1sn0B-3obwA:
undetectable
1sn0D-3obwA:
undetectable		 1sn0B-3obwA:
17.54
1sn0D-3obwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 LEU A 321
GLU A 303
ALA A 285
ALA A 291
 None
 0.85A 1sn0B-3oepA:
undetectable
1sn0D-3oepA:
undetectable		 1sn0B-3oepA:
13.44
1sn0D-3oepA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of3 PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE 1

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		4 LYS A  40
LEU A  37
GLU A  44
ALA A  39
 None
 1.15A 1sn0B-3of3A:
undetectable
1sn0D-3of3A:
undetectable		 1sn0B-3of3A:
21.46
1sn0D-3of3A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2n 3,6-ANHYDRO-ALPHA-L-
GALACTOSIDASE

(Zobellia
galactanivorans) 		PF04616
(Glyco_hydro_43) 		4 GLU A 153
ALA A 156
LEU A 184
ALA A 206
 None
 1.10A 1sn0B-3p2nA:
undetectable
1sn0D-3p2nA:
undetectable		 1sn0B-3p2nA:
14.96
1sn0D-3p2nA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 LEU A 568
LYS A 585
LEU A 582
ALA A 584
 None
 1.07A 1sn0B-3sfzA:
undetectable
1sn0D-3sfzA:
undetectable		 1sn0B-3sfzA:
7.57
1sn0D-3sfzA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 LEU A 706
GLU A 656
ALA A 709
ALA A 648
 None
 1.07A 1sn0B-3w5nA:
undetectable
1sn0D-3w5nA:
undetectable		 1sn0B-3w5nA:
8.78
1sn0D-3w5nA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(Aquifex
aeolicus;
synthetic
construct) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 LYS A 196
LEU A  49
GLU A 195
ALA A 136
 None
 1.03A 1sn0B-3wfpA:
undetectable
1sn0D-3wfpA:
undetectable		 1sn0B-3wfpA:
15.53
1sn0D-3wfpA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 LEU A 106
ALA A  66
LEU A 129
ALA A  78
 None
 1.00A 1sn0B-3wnpA:
2.0
1sn0D-3wnpA:
2.0		 1sn0B-3wnpA:
11.13
1sn0D-3wnpA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 LEU A 129
ALA A  78
LEU A 106
ALA A  66
 None
 0.98A 1sn0B-3wnpA:
2.0
1sn0D-3wnpA:
2.0		 1sn0B-3wnpA:
11.13
1sn0D-3wnpA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Bos taurus) 		PF00118
(Cpn60_TCP1) 		4 GLU A  95
ALA A  19
LEU A  71
ALA A 497
 None
 1.01A 1sn0B-4a0wA:
undetectable
1sn0D-4a0wA:
undetectable		 1sn0B-4a0wA:
15.81
1sn0D-4a0wA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aby DNA REPAIR PROTEIN
RECN

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 LEU A 125
GLU A 137
ALA A 139
ALA A 123
 None
 1.15A 1sn0B-4abyA:
undetectable
1sn0D-4abyA:
undetectable		 1sn0B-4abyA:
15.69
1sn0D-4abyA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5

(Escherichia
coli;
Macaca mulatta) 		PF00622
(SPRY)
PF01547
(SBP_bac_1) 		4 LYS A 277
GLU A 281
ALA A 276
ALA A  77
 None
 1.16A 1sn0B-4b3nA:
undetectable
1sn0D-4b3nA:
undetectable		 1sn0B-4b3nA:
13.26
1sn0D-4b3nA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cta CINA-LIKE PROTEIN

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth)
PF02464
(CinA) 		4 LEU A  50
GLU A  80
ALA A  85
LEU A 147
 None
 1.04A 1sn0B-4ctaA:
undetectable
1sn0D-4ctaA:
undetectable		 1sn0B-4ctaA:
15.21
1sn0D-4ctaA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		4 LEU A 277
ALA A 418
LEU A 375
ALA A 352
 None
 1.03A 1sn0B-4fqdA:
undetectable
1sn0D-4fqdA:
undetectable		 1sn0B-4fqdA:
15.93
1sn0D-4fqdA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		4 LEU A 375
ALA A 352
LEU A 277
ALA A 418
 None
 1.04A 1sn0B-4fqdA:
undetectable
1sn0D-4fqdA:
undetectable		 1sn0B-4fqdA:
15.93
1sn0D-4fqdA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		4 LYS A  42
LEU A  44
GLU A  55
LEU A  91
 None
 1.10A 1sn0B-4ftdA:
3.3
1sn0D-4ftdA:
undetectable		 1sn0B-4ftdA:
13.53
1sn0D-4ftdA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 GLU M 103
ALA M   5
LEU M  67
ALA M 111
 None
 1.14A 1sn0B-4heaM:
undetectable
1sn0D-4heaM:
undetectable		 1sn0B-4heaM:
14.38
1sn0D-4heaM:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 LYS A 278
GLU A 282
ALA A 277
ALA A  78
 None
 1.06A 1sn0B-4ifpA:
undetectable
1sn0D-4ifpA:
undetectable		 1sn0B-4ifpA:
15.25
1sn0D-4ifpA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		4 LYS A 317
GLU A 277
ALA A 332
LEU A 160
 None
 1.08A 1sn0B-4kdsA:
undetectable
1sn0D-4kdsA:
undetectable		 1sn0B-4kdsA:
15.49
1sn0D-4kdsA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber) 		PF01048
(PNP_UDP_1) 		4 LYS A  26
LEU A  23
GLU A  30
ALA A  25
 None
 1.13A 1sn0B-4m3nA:
undetectable
1sn0D-4m3nA:
undetectable		 1sn0B-4m3nA:
18.75
1sn0D-4m3nA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		4 LYS A 142
GLU A 141
LEU A  98
ALA A 101
 None
 1.00A 1sn0B-4mcoA:
undetectable
1sn0D-4mcoA:
undetectable		 1sn0B-4mcoA:
18.15
1sn0D-4mcoA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oz5 BACILLUS SUBTILIS
HMOB

(Bacillus
subtilis) 		PF03992
(ABM) 		4 LEU A  26
GLU A  39
LEU A  69
ALA A  67
 None
 0.93A 1sn0B-4oz5A:
undetectable
1sn0D-4oz5A:
undetectable		 1sn0B-4oz5A:
25.00
1sn0D-4oz5A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 478
ALA A 481
LEU A 569
ALA A 606
 None
 0.90A 1sn0B-4q9zA:
undetectable
1sn0D-4q9zA:
undetectable		 1sn0B-4q9zA:
15.11
1sn0D-4q9zA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 569
ALA A 606
LEU A 478
ALA A 481
 None
 0.88A 1sn0B-4q9zA:
undetectable
1sn0D-4q9zA:
undetectable		 1sn0B-4q9zA:
15.11
1sn0D-4q9zA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLU A 295
ALA A 321
LYS A 288
ALA A 286
 None
 1.16A 1sn0B-4qavA:
undetectable
1sn0D-4qavA:
undetectable		 1sn0B-4qavA:
17.44
1sn0D-4qavA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA

(Escherichia
coli;
Mus musculus) 		PF13416
(SBP_bac_8)
PF13621
(Cupin_8) 		4 LYS A -94
GLU A -90
ALA A -95
ALA A-294
 None
 1.15A 1sn0B-4qszA:
undetectable
1sn0D-4qszA:
undetectable		 1sn0B-4qszA:
12.93
1sn0D-4qszA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 477
ALA A 517
LEU A 489
ALA A 492
 None
 0.87A 1sn0B-4wkyA:
undetectable
1sn0D-4wkyA:
undetectable		 1sn0B-4wkyA:
15.50
1sn0D-4wkyA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwr LARGE PROLINE-RICH
PROTEIN BAG6
UBIQUITIN-LIKE
PROTEIN 4A

(Homo sapiens) 		no annotation 4 LEU A1079
GLU A1084
LEU B 119
ALA A1065
 None
 1.07A 1sn0B-4wwrA:
undetectable
1sn0D-4wwrA:
undetectable		 1sn0B-4wwrA:
18.26
1sn0D-4wwrA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 LEU A 606
GLU A 554
LEU A 592
ALA A 618
 None
 1.16A 1sn0B-4xhjA:
undetectable
1sn0D-4xhjA:
undetectable		 1sn0B-4xhjA:
10.74
1sn0D-4xhjA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LYS A 360
GLU A 329
ALA A 361
ALA A 349
 None
 1.11A 1sn0B-5b25A:
undetectable
1sn0D-5b25A:
undetectable		 1sn0B-5b25A:
19.26
1sn0D-5b25A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		4 LEU A 412
GLU A  15
LEU A 242
ALA A 245
 None
 1.08A 1sn0B-5bq2A:
undetectable
1sn0D-5bq2A:
undetectable		 1sn0B-5bq2A:
16.55
1sn0D-5bq2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LEU A 620
GLU A 664
LEU A 472
ALA A 149
 None
 1.16A 1sn0B-5chcA:
undetectable
1sn0D-5chcA:
undetectable		 1sn0B-5chcA:
9.79
1sn0D-5chcA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7l MAV36 TCR ALPHA
CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 LYS D  37
LEU D  46
GLU D  39
LEU D  21
 None
 1.06A 1sn0B-5d7lD:
undetectable
1sn0D-5d7lD:
undetectable		 1sn0B-5d7lD:
19.29
1sn0D-5d7lD:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd8 TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Deinococcus
radiodurans) 		PF12802
(MarR_2) 		4 LEU A  46
LYS A   8
LEU A  12
ALA A  10
 None
 1.14A 1sn0B-5dd8A:
undetectable
1sn0D-5dd8A:
undetectable		 1sn0B-5dd8A:
22.09
1sn0D-5dd8A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd8 TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Deinococcus
radiodurans) 		PF12802
(MarR_2) 		4 LYS A   8
LEU A  12
ALA A  10
LEU A  46
 None
 1.10A 1sn0B-5dd8A:
undetectable
1sn0D-5dd8A:
undetectable		 1sn0B-5dd8A:
22.09
1sn0D-5dd8A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA,
TFA2

(Saccharomyces
cerevisiae) 		PF02186
(TFIIE_beta) 		4 LEU S 163
GLU S 161
LYS S 127
ALA S 131
 None
 1.04A 1sn0B-5fmfS:
undetectable
1sn0D-5fmfS:
undetectable		 1sn0B-5fmfS:
20.13
1sn0D-5fmfS:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 LYS A 278
GLU A 282
ALA A 277
ALA A  78
 None
 1.14A 1sn0B-5gpqA:
undetectable
1sn0D-5gpqA:
undetectable		 1sn0B-5gpqA:
14.69
1sn0D-5gpqA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il6 POLYKETIDE
SYNTHASE/NONRIBOSOMA
L PEPTIDE SYNTHETASE
HYBRID RZXB

(Pseudomonas
protegens) 		PF14765
(PS-DH) 		4 LEU A4606
ALA A4569
LEU A4637
ALA A4635
 None
 0.74A 1sn0B-5il6A:
undetectable
1sn0D-5il6A:
undetectable		 1sn0B-5il6A:
17.53
1sn0D-5il6A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il6 POLYKETIDE
SYNTHASE/NONRIBOSOMA
L PEPTIDE SYNTHETASE
HYBRID RZXB

(Pseudomonas
protegens) 		PF14765
(PS-DH) 		4 LEU A4637
ALA A4635
LEU A4606
ALA A4569
 None
 0.74A 1sn0B-5il6A:
undetectable
1sn0D-5il6A:
undetectable		 1sn0B-5il6A:
17.53
1sn0D-5il6A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN

(Bordetella
parapertussis) 		PF13407
(Peripla_BP_4) 		4 GLU A 309
ALA A 304
LEU A  57
ALA A  80
 None
 1.16A 1sn0B-5ix8A:
undetectable
1sn0D-5ix8A:
undetectable		 1sn0B-5ix8A:
18.81
1sn0D-5ix8A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		4 LEU A 155
GLU A 165
LEU A  42
ALA A 111
 None
 1.05A 1sn0B-5k52A:
undetectable
1sn0D-5k52A:
undetectable		 1sn0B-5k52A:
17.84
1sn0D-5k52A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 GLU A 303
ALA A 333
LEU A 322
ALA A 320
 None
 1.02A 1sn0B-5l3rA:
undetectable
1sn0D-5l3rA:
undetectable		 1sn0B-5l3rA:
19.93
1sn0D-5l3rA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfd YIIIM''6AII

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A 265
GLU A 303
ALA A 306
LEU A 332
 None
 0.94A 1sn0B-5mfdA:
undetectable
1sn0D-5mfdA:
undetectable		 1sn0B-5mfdA:
18.81
1sn0D-5mfdA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nl1 TALIN-1

(Mus musculus) 		no annotation 4 LYS A 535
LEU A 593
GLU A 538
LEU A 522
 None
 0.99A 1sn0B-5nl1A:
undetectable
1sn0D-5nl1A:
undetectable		 1sn0B-5nl1A:
22.90
1sn0D-5nl1A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm GENERAL
TRANSCRIPTION AND
DNA REPAIR FACTOR
IIH HELICASE SUBUNIT
XPB

(Saccharomyces
cerevisiae) 		no annotation 4 LYS 7 766
LEU 7 579
GLU 7 769
ALA 7 614
 None
 1.01A 1sn0B-5oqm7:
undetectable
1sn0D-5oqm7:
undetectable		 1sn0B-5oqm7:
24.41
1sn0D-5oqm7:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA

(Acinetobacter
baumannii;
Escherichia
coli) 		no annotation 4 LYS A 277
GLU A 281
ALA A 276
ALA A  77
 None
 1.16A 1sn0B-5vawA:
undetectable
1sn0D-5vawA:
undetectable		 1sn0B-5vawA:
23.20
1sn0D-5vawA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xon GENERAL
TRANSCRIPTION
ELONGATION FACTOR
TFIIS

(Komagataella
phaffii) 		PF01096
(TFIIS_C)
PF07500
(TFIIS_M) 		4 LEU U 175
LYS U 161
LEU U 204
ALA U 162
 None
 1.16A 1sn0B-5xonU:
undetectable
1sn0D-5xonU:
undetectable		 1sn0B-5xonU:
21.39
1sn0D-5xonU:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xon GENERAL
TRANSCRIPTION
ELONGATION FACTOR
TFIIS

(Komagataella
phaffii) 		PF01096
(TFIIS_C)
PF07500
(TFIIS_M) 		4 LYS U 161
LEU U 204
ALA U 162
LEU U 175
 None
 1.14A 1sn0B-5xonU:
undetectable
1sn0D-5xonU:
undetectable		 1sn0B-5xonU:
21.39
1sn0D-5xonU:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 4 GLU A 384
LYS A 357
LEU A 394
ALA A 361
 None
 0.94A 1sn0B-5zb8A:
undetectable
1sn0D-5zb8A:
undetectable		 1sn0B-5zb8A:
18.90
1sn0D-5zb8A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 4 LYS A  33
GLU A 336
ALA A  30
ALA A 194
 None
 0.90A 1sn0B-5zb8A:
undetectable
1sn0D-5zb8A:
undetectable		 1sn0B-5zb8A:
18.90
1sn0D-5zb8A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax8 METHIONINE-TRNA
LIGASE

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A 355
ALA A 460
LEU A 478
ALA A 359
 None
 1.11A 1sn0B-6ax8A:
undetectable
1sn0D-6ax8A:
undetectable		 1sn0B-6ax8A:
21.88
1sn0D-6ax8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax8 METHIONINE-TRNA
LIGASE

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A 478
ALA A 359
LEU A 355
ALA A 460
 None
 1.10A 1sn0B-6ax8A:
undetectable
1sn0D-6ax8A:
undetectable		 1sn0B-6ax8A:
21.88
1sn0D-6ax8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 4 LEU A  87
GLU A  85
ALA A 129
LEU A  26
 None
 1.07A 1sn0B-6chjA:
undetectable
1sn0D-6chjA:
undetectable		 1sn0B-6chjA:
20.30
1sn0D-6chjA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 4 ALA A 340
LYS A 314
LEU A 310
ALA A 313
 None
 1.17A 1sn0B-6cjbA:
undetectable
1sn0D-6cjbA:
undetectable		 1sn0B-6cjbA:
19.17
1sn0D-6cjbA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE

(Staphylococcus
hominis) 		no annotation 4 LEU A 299
ALA A 295
LYS A 431
ALA A 428
 None
 1.03A 1sn0B-6exsA:
undetectable
1sn0D-6exsA:
undetectable		 1sn0B-6exsA:
18.80
1sn0D-6exsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE

(Staphylococcus
hominis) 		no annotation 4 LYS A 431
ALA A 428
LEU A 299
ALA A 295
 None
 1.02A 1sn0B-6exsA:
undetectable
1sn0D-6exsA:
undetectable		 1sn0B-6exsA:
18.80
1sn0D-6exsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis) 		no annotation 4 LEU A  78
GLU A 113
ALA A 106
LEU A  74
 None
 1.10A 1sn0B-6f2cA:
undetectable
1sn0D-6f2cA:
undetectable		 1sn0B-6f2cA:
17.29
1sn0D-6f2cA:
17.29