SIMILAR PATTERNS OF AMINO ACIDS FOR 1SKX_A_RFPA1_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cbg | CYANOGENICBETA-GLUCOSIDASE (Trifoliumrepens) |
PF00232(Glyco_hydro_1) | 4 | PHE A 444LEU A 488MET A 82LEU A 125 | None | 1.15A | 1skxA-1cbgA:0.0 | 1skxA-1cbgA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f0i | PHOSPHOLIPASE D (Streptomycessp. PMF) |
PF13091(PLDc_2) | 4 | LYS A 464PHE A 459LEU A 326LEU A 182 | None | 1.38A | 1skxA-1f0iA:0.0 | 1skxA-1f0iA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kbl | PYRUVATE PHOSPHATEDIKINASE ([Clostridium]symbiosum) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 4 | LYS A 678PHE A 626LEU A 591LEU A 707 | NoneNoneNoneNH4 A 901 ( 4.3A) | 1.08A | 1skxA-1kblA:0.0 | 1skxA-1kblA:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ni3 | YCHF GTP-BINDINGPROTEIN (Schizosaccharomycespombe) |
PF01926(MMR_HSR1)PF06071(YchF-GTPase_C) | 4 | LYS A 250PHE A 126LEU A 246MET A 265 | None | 1.32A | 1skxA-1ni3A:0.0 | 1skxA-1ni3A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xqs | HSPBP1 PROTEIN (Homo sapiens) |
PF08609(Fes1) | 4 | PHE A 232LEU A 209MET A 239LEU A 296 | None | 1.36A | 1skxA-1xqsA:0.0 | 1skxA-1xqsA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yy5 | FMS1 PROTEIN (Saccharomycescerevisiae) |
PF01593(Amino_oxidase) | 4 | PHE A 130LEU A 171MET A 122LEU A 150 | None | 1.40A | 1skxA-1yy5A:0.0 | 1skxA-1yy5A:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zof | ALKYLHYDROPEROXIDE-REDUCTASE (Helicobacterpylori) |
PF00578(AhpC-TSA)PF10417(1-cysPrx_C) | 4 | LYS A 5PHE A 10LEU A 6LEU A 116 | None | 1.39A | 1skxA-1zofA:0.0 | 1skxA-1zofA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b25 | HYPOTHETICAL PROTEIN (Homo sapiens) |
PF08704(GCD14) | 4 | LYS A 44PHE A 53LEU A 58LEU A 157 | None | 1.22A | 1skxA-2b25A:0.0 | 1skxA-2b25A:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c47 | CASEIN KINASE 1GAMMA 2 ISOFORM (Homo sapiens) |
PF00069(Pkinase) | 4 | LYS A 159PHE A 171LEU A 96LEU A 308 | None | 1.20A | 1skxA-2c47A:undetectable | 1skxA-2c47A:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eig | LECTIN (Lotustetragonolobus) |
PF00139(Lectin_legB) | 4 | PHE A 66LEU A 14MET A 30LEU A 102 | None | 1.50A | 1skxA-2eigA:undetectable | 1skxA-2eigA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iew | INOSITOLPOLYPHOSPHATEMULTIKINASE (Saccharomycescerevisiae) |
PF03770(IPK) | 4 | LYS A 229PHE A 124LEU A 224LEU A 259 | None | 1.40A | 1skxA-2iewA:undetectable | 1skxA-2iewA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nz9 | BOTULINUM NEUROTOXINTYPE A (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 4 | LYS A 84PHE A 163LEU A 78LEU A 151 | None | 1.47A | 1skxA-2nz9A:undetectable | 1skxA-2nz9A:13.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p6r | AFUHEL308 HELICASE (Archaeoglobusfulgidus) |
PF00270(DEAD)PF00271(Helicase_C) | 4 | LYS A 53PHE A 38LEU A 45LEU A 96 | None | 1.43A | 1skxA-2p6rA:undetectable | 1skxA-2p6rA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d4o | DIPICOLINATESYNTHASE SUBUNIT A (Bacillushalodurans) |
PF01262(AlaDh_PNT_C)PF16924(DpaA_N) | 4 | LYS A 172PHE A 150LEU A 176LEU A 262 | None | 1.43A | 1skxA-3d4oA:undetectable | 1skxA-3d4oA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e02 | UNCHARACTERIZEDPROTEIN DUF849 (Paraburkholderiaxenovorans) |
PF05853(BKACE) | 4 | PHE A 151LEU A 94MET A 158LEU A 196 | NoneEDO A 320 (-4.5A)NoneNone | 1.16A | 1skxA-3e02A:undetectable | 1skxA-3e02A:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f1c | PUTATIVE2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATECYTIDYLYLTRANSFERASE2 (Listeriamonocytogenes) |
PF01128(IspD) | 4 | PHE A 171LEU A 100MET A 88LEU A 183 | None | 1.40A | 1skxA-3f1cA:undetectable | 1skxA-3f1cA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fgq | NEUROSERPIN (Homo sapiens) |
PF00079(Serpin) | 4 | LYS A 82PHE A 89LEU A 81MET A 76 | None | 1.47A | 1skxA-3fgqA:undetectable | 1skxA-3fgqA:25.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gkj | NIEMANN-PICK C1PROTEIN (Homo sapiens) |
PF16414(NPC1_N) | 4 | PHE A 101LEU A 173MET A 156LEU A 111 | None | 1.18A | 1skxA-3gkjA:undetectable | 1skxA-3gkjA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gnr | OS03G0212800 PROTEIN (Oryza sativa) |
PF00232(Glyco_hydro_1) | 4 | PHE A 442LEU A 486MET A 79LEU A 120 | PHE A 442 ( 1.3A)LEU A 486 ( 0.6A)MET A 79 ( 0.0A)LEU A 120 ( 0.6A) | 1.10A | 1skxA-3gnrA:undetectable | 1skxA-3gnrA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jbr | VOLTAGE-DEPENDENTCALCIUM CHANNELSUBUNITALPHA-2/DELTA-1 (Oryctolaguscuniculus) |
PF00092(VWA)PF08399(VWA_N)PF08473(VGCC_alpha2) | 4 | PHE F 363LEU F 320MET F 256LEU F 429 | None | 1.47A | 1skxA-3jbrF:undetectable | 1skxA-3jbrF:12.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jd8 | NIEMANN-PICK C1PROTEIN (Homo sapiens) |
PF02460(Patched)PF12349(Sterol-sensing)PF16414(NPC1_N) | 4 | PHE A 101LEU A 173MET A 156LEU A 111 | None | 1.17A | 1skxA-3jd8A:1.0 | 1skxA-3jd8A:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k8p | DSL1PROTEIN TRANSPORTPROTEIN SEC39 (Kluyveromyceslactis;Saccharomycescerevisiae) |
PF08314(Sec39)PF11989(Dsl1_C) | 4 | PHE C 438LEU D 651MET C 344LEU C 458 | None | 1.45A | 1skxA-3k8pC:undetectable | 1skxA-3k8pC:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m62 | UBIQUITINCONJUGATION FACTORE4 (Saccharomycescerevisiae) |
PF04564(U-box)PF10408(Ufd2P_core) | 4 | PHE A 211LEU A 388MET A 312LEU A 295 | None | 1.38A | 1skxA-3m62A:undetectable | 1skxA-3m62A:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oo9 | ABC TRANSPORTERBINDING PROTEIN ACBH (Actinoplanessp. SE50/110) |
PF01547(SBP_bac_1) | 4 | PHE A 359LEU A 188MET A 200LEU A 375 | GOL A 414 (-3.5A)NoneNoneNone | 1.45A | 1skxA-3oo9A:undetectable | 1skxA-3oo9A:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ptk | BETA-GLUCOSIDASEOS4BGLU12 (Oryza sativa) |
PF00232(Glyco_hydro_1) | 4 | PHE A 440LEU A 484MET A 78LEU A 121 | None | 0.97A | 1skxA-3ptkA:undetectable | 1skxA-3ptkA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qa8 | MGC80376 PROTEIN (Xenopus laevis) |
PF00069(Pkinase) | 4 | PHE A 390LEU A 353MET A 315LEU A 448 | None | 1.49A | 1skxA-3qa8A:undetectable | 1skxA-3qa8A:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sv0 | CASEIN KINASE I-LIKE (Oryza sativa) |
PF00069(Pkinase) | 4 | LYS A 122PHE A 134LEU A 59LEU A 269 | None | 1.39A | 1skxA-3sv0A:undetectable | 1skxA-3sv0A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u1t | DMMA HALOALKANEDEHALOGENASE (unidentified) |
PF00561(Abhydrolase_1) | 4 | PHE A 210LEU A 84MET A 107LEU A 119 | CL A 350 (-4.7A)NoneNoneNone | 1.45A | 1skxA-3u1tA:undetectable | 1skxA-3u1tA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vr1 | PEPTIDE CHAINRELEASE FACTOR 3 (Desulfovibriovulgaris) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF16658(RF3_C) | 4 | PHE A 253LEU A 249MET A 154LEU A 229 | None | 1.39A | 1skxA-3vr1A:undetectable | 1skxA-3vr1A:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wh7 | BETA-GLUCOSIDASE (metagenomes) |
PF00232(Glyco_hydro_1) | 4 | PHE A 243LEU A 187MET A 264LEU A 252 | None | 0.99A | 1skxA-3wh7A:undetectable | 1skxA-3wh7A:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvm | UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D- ALANINE LIGASE (Pseudomonasaeruginosa) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 4 | PHE A 407LEU A 420MET A 400LEU A 348 | None | 1.46A | 1skxA-4cvmA:undetectable | 1skxA-4cvmA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dg5 | PHOSPHOGLYCERATEKINASE (Staphylococcusaureus) |
PF00162(PGK) | 4 | PHE A 250LEU A 264MET A 226LEU A 379 | None | 1.42A | 1skxA-4dg5A:undetectable | 1skxA-4dg5A:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eb0 | LCC (unculturedbacterium) |
PF12695(Abhydrolase_5) | 4 | PHE A 114LEU A 139MET A 91LEU A 203 | None | 1.43A | 1skxA-4eb0A:undetectable | 1skxA-4eb0A:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4esa | HEMOGLOBIN ALPHACHAIN (Eleginopsmaclovinus) |
PF00042(Globin) | 4 | LYS A 73LEU A 81MET A 64LEU A 13 | None | 1.46A | 1skxA-4esaA:undetectable | 1skxA-4esaA:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hpe | PUTATIVE CELL WALLHYDROLASETN916-LIKE,CTN1-ORF17 (Clostridioidesdifficile) |
PF00877(NLPC_P60)PF13702(Lysozyme_like) | 4 | LYS A 60PHE A 116MET A 90LEU A 47 | None | 1.48A | 1skxA-4hpeA:undetectable | 1skxA-4hpeA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m7e | PROTEINBRASSINOSTEROIDINSENSITIVE 1 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF12799(LRR_4)PF13516(LRR_6)PF13855(LRR_8) | 4 | PHE A 658LEU A 707MET A 677LEU A 556 | None | 1.41A | 1skxA-4m7eA:undetectable | 1skxA-4m7eA:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n0t | U4/U6SNRNA-ASSOCIATED-SPLICING FACTOR PRP24 (Saccharomycescerevisiae) |
PF00076(RRM_1)PF16842(RRM_occluded) | 4 | PHE A 234LEU A 286MET A 258LEU A 226 | None | 1.47A | 1skxA-4n0tA:undetectable | 1skxA-4n0tA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4na3 | POLYKETIDE SYNTHASEPKSJ (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 4 | PHE A 78LEU A 114MET A 159LEU A 95 | None | 1.43A | 1skxA-4na3A:undetectable | 1skxA-4na3A:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o7z | PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (Pyrococcushorikoshii) |
PF01259(SAICAR_synt) | 4 | LYS A 82PHE A 27LEU A 23LEU A 176 | None | 1.27A | 1skxA-4o7zA:undetectable | 1skxA-4o7zA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ou4 | ALPHA/BETA HYDROLASEFOLD-3 DOMAINPROTEIN (Pseudomonas sp.ECU1011) |
PF07859(Abhydrolase_3) | 4 | LYS A 173PHE A 84LEU A 170LEU A 315 | None | 1.43A | 1skxA-4ou4A:undetectable | 1skxA-4ou4A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pj3 | INTRON-BINDINGPROTEIN AQUARIUS (Homo sapiens) |
PF13086(AAA_11)PF13087(AAA_12)PF16399(Aquarius_N) | 4 | PHE A1123LEU A1088MET A1061LEU A1068 | None | 1.31A | 1skxA-4pj3A:undetectable | 1skxA-4pj3A:11.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qlj | BETA-GLUCOSIDASE 7 (Oryza sativa) |
PF00232(Glyco_hydro_1) | 4 | PHE A 431LEU A 474MET A 77LEU A 118 | None | 1.09A | 1skxA-4qljA:undetectable | 1skxA-4qljA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rmx | PHI92_GP150 (Enterobacteriaphage phi92) |
no annotation | 4 | LYS A 311PHE A 323MET A 355LEU A 363 | None | 1.20A | 1skxA-4rmxA:undetectable | 1skxA-4rmxA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqk | LECTIN 2 (Agrocybeaegerita) |
PF13517(VCBS) | 4 | LYS A 377PHE A 342LEU A 379LEU A 291 | None | 1.45A | 1skxA-4tqkA:undetectable | 1skxA-4tqkA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uav | HALOACIDDEHALOGENASE-LIKEHYDROLASEDOMAIN-CONTAININGPROTEIN AT3G48420 (Arabidopsisthaliana) |
PF13419(HAD_2) | 4 | LYS A 252PHE A 304LEU A 313LEU A 188 | None | 1.28A | 1skxA-4uavA:undetectable | 1skxA-4uavA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xyd | NITRIC-OXIDEREDUCTASE SUBUNIT B (Roseobacterdenitrificans) |
PF00115(COX1) | 4 | PHE A 339LEU A 348MET A 380LEU A 30 | HEM A 504 ( 3.8A)NoneHEM A 501 (-4.3A)HEM A 501 (-3.7A) | 1.23A | 1skxA-4xydA:1.6 | 1skxA-4xydA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b6a | PYRIDOXAL KINASEPDXY (Pseudomonasaeruginosa) |
PF08543(Phos_pyr_kin) | 4 | PHE A 283LEU A 213MET A 198LEU A 230 | None | 1.45A | 1skxA-5b6aA:undetectable | 1skxA-5b6aA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c6u | AMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF12897(Aminotran_MocR) | 4 | LYS A 291PHE A 301LEU A 75LEU A 51 | None | 1.36A | 1skxA-5c6uA:undetectable | 1skxA-5c6uA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e2g | BETA-LACTAMASE (Burkholderiacenocepacia) |
PF00144(Beta-lactamase) | 4 | PHE A 165LEU A 101MET A 161LEU A 243 | NoneNoneNoneSCN A 402 ( 4.0A) | 1.42A | 1skxA-5e2gA:undetectable | 1skxA-5e2gA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7u | CYCLOALTERNAN-FORMING ENZYME (Listeriamonocytogenes) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF16990(CBM_35) | 4 | PHE A 181LEU A 164MET A 189LEU A 243 | None | 1.44A | 1skxA-5f7uA:undetectable | 1skxA-5f7uA:13.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fqd | CASEIN KINASE IISOFORM ALPHA (Homo sapiens) |
PF00069(Pkinase) | 4 | LYS C 130PHE C 142LEU C 67LEU C 277 | None | 1.48A | 1skxA-5fqdC:undetectable | 1skxA-5fqdC:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5t | ARGONAUTE (Methanocaldococcusjannaschii) |
PF02171(Piwi) | 4 | LYS A 354LEU A 356MET A 481LEU A 343 | None | 1.08A | 1skxA-5g5tA:undetectable | 1skxA-5g5tA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hwq | HYDROXYMETHYLGLUTARYL-COA SYNTHASE (Myxococcusxanthus) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 4 | LYS A 259PHE A 348LEU A 213LEU A 322 | CAA A 501 (-2.7A)NoneNoneNone | 1.21A | 1skxA-5hwqA:undetectable | 1skxA-5hwqA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3e | PUTATIVEDEOXYRIBONUCLEASE-2 (Burkholderiathailandensis) |
PF03265(DNase_II) | 4 | LYS A 102PHE A 200LEU A 118LEU A 160 | NoneNoneEDO A 400 (-4.3A)None | 1.39A | 1skxA-5i3eA:undetectable | 1skxA-5i3eA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mil | DUTPASE FAMILYPROTEIN (Staphylococcusaureus) |
PF08761(dUTPase_2) | 4 | PHE A 41LEU A 120MET A 71LEU A 136 | None | 0.94A | 1skxA-5milA:undetectable | 1skxA-5milA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nth | PUTATIVEAMINOPEPTIDASE (Leishmaniamajor) |
PF00883(Peptidase_M17) | 4 | PHE A 347LEU A 244MET A 342LEU A 207 | None | 1.26A | 1skxA-5nthA:undetectable | 1skxA-5nthA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uin | FORMYLTRANSFERASE (Salmonellaenterica) |
PF00551(Formyl_trans_N)PF13637(Ank_4) | 4 | LYS A 280PHE A 298LEU A 276LEU A 363 | None | 1.45A | 1skxA-5uinA:undetectable | 1skxA-5uinA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vhj | 26S PROTEASOMEREGULATORY SUBUNIT10B (Homo sapiens) |
PF00004(AAA) | 4 | LYS E 298PHE E 231LEU E 295LEU E 182 | None | 1.29A | 1skxA-5vhjE:undetectable | 1skxA-5vhjE:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5voc | ENVELOPEGLYCOPROTEIN HENVELOPEGLYCOPROTEIN L (Humanbetaherpesvirus5) |
PF01801(Cytomega_gL)PF02489(Herpes_glycop_H)PF17488(Herpes_glycoH_C) | 4 | PHE B 232LEU B 246MET A 92LEU B 56 | None | 1.48A | 1skxA-5vocB:undetectable | 1skxA-5vocB:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5whs | CATALASE-PEROXIDASE (Neurosporacrassa) |
no annotation | 4 | PHE A 726LEU A 618MET A 734LEU A 480 | None | 1.48A | 1skxA-5whsA:undetectable | 1skxA-5whsA:15.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wvg | CHITINASE (Ostriniafurnacalis) |
no annotation | 4 | PHE A 658LEU A 568MET A 623LEU A 667 | None | 1.28A | 1skxA-5wvgA:undetectable | 1skxA-5wvgA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6x | MRNA CAPPING ENZYMEP5 (Rice dwarfvirus) |
no annotation | 4 | PHE C 461LEU C 233MET C 465LEU C 406 | None | 1.26A | 1skxA-5x6xC:undetectable | 1skxA-5x6xC:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xag | TUBULIN TYROSINELIGASE (Gallus gallus) |
no annotation | 4 | LYS F 184PHE F 319LEU F 186LEU F 87 | NoneNoneACP F 402 (-4.0A)None | 1.21A | 1skxA-5xagF:undetectable | 1skxA-5xagF:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xon | PROTEIN THAT FORMS ACOMPLEX WITH SPT4PTRANSCRIPTIONELONGATION FACTORSPT4 (Komagataellaphaffii) |
PF00467(KOW)PF03439(Spt5-NGN)PF06093(Spt4) | 4 | LYS V 9PHE V 77LEU V 19LEU W 310 | None | 1.47A | 1skxA-5xonV:undetectable | 1skxA-5xonV:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f1e | INTERFERON GAMMA (Paralichthysolivaceus) |
no annotation | 4 | LYS A 122PHE A 55LEU A 126LEU A 38 | None | 1.31A | 1skxA-6f1eA:undetectable | 1skxA-6f1eA:14.55 |