SIMILAR PATTERNS OF AMINO ACIDS FOR 1SKX_A_RFPA1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cby DELTA-ENDOTOXIN CYTB

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		5 VAL A 193
LEU A 189
GLN A 149
TRP A 157
PHE A 173
 None
 1.46A 1skxA-1cbyA:
0.0		 1skxA-1cbyA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfj 3-DEHYDROQUINATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF01487
(DHquinase_I) 		5 LEU A  34
GLN A  22
ARG A  27
ILE A  31
PHE A  63
 None
 1.46A 1skxA-1sfjA:
undetectable		 1skxA-1sfjA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		5 VAL A   3
LEU A 186
SER A  95
HIS A 218
PHE A 192
 None
 1.44A 1skxA-1x9sA:
0.0		 1skxA-1x9sA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfj DNA ADENINE
METHYLASE

(Escherichia
virus T4) 		PF02086
(MethyltransfD12) 		5 VAL A  70
LEU A 103
PHE A 152
CYH A 147
ILE A 115
 None
 1.46A 1skxA-1yfjA:
0.0		 1skxA-1yfjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6g GUANYLATE KINASE

(Plasmodium
falciparum) 		PF00625
(Guanylate_kin) 		5 VAL A 107
LEU A  99
SER A  37
ILE A  21
PHE A  34
 None
 1.33A 1skxA-1z6gA:
0.0		 1skxA-1z6gA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9q 11S GLOBULIN SUBUNIT
BETA

(Cucurbita
maxima) 		PF00190
(Cupin_1) 		5 VAL A 371
MET A 347
SER A 345
HIS A 338
ILE A 306
 None
None
None
CL  A2001 (-4.4A)
None
 1.44A 1skxA-2e9qA:
0.0		 1skxA-2e9qA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqy JUMONJI, AT RICH
INTERACTIVE DOMAIN
1B

(Mus musculus) 		PF01388
(ARID) 		5 LEU A 130
PHE A 143
CYH A 147
ARG A 177
ILE A 178
 None
 1.31A 1skxA-2eqyA:
0.0		 1skxA-2eqyA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqy JUMONJI, AT RICH
INTERACTIVE DOMAIN
1B

(Mus musculus) 		PF01388
(ARID) 		5 VAL A 123
LEU A 130
PHE A 143
CYH A 147
ARG A 177
 None
 1.47A 1skxA-2eqyA:
0.0		 1skxA-2eqyA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		5 VAL A   3
LEU A  27
SER A  70
PHE A  31
ILE A  19
 None
None
None
EDO  A 357 (-4.8A)
None
 1.47A 1skxA-3alfA:
0.0		 1skxA-3alfA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc6 ECTO-NAD+
GLYCOHYDROLASE (CD38
MOLECULE)

(Bos taurus) 		PF02267
(Rib_hydrolayse) 		5 VAL A 196
LEU A 252
ARG A 259
ILE A 255
PHE A 208
 None
 1.50A 1skxA-3gc6A:
undetectable		 1skxA-3gc6A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		5 VAL A  24
LEU A  41
SER A   9
ARG A  98
PHE A 132
 None
None
FMN  A 504 ( 4.7A)
None
None
 1.40A 1skxA-3gg0A:
undetectable		 1skxA-3gg0A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Comamonas
testosteroni) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 VAL A  95
TRP A 176
HIS A 341
ILE A 211
PHE A 353
 None
 1.48A 1skxA-3gzyA:
undetectable		 1skxA-3gzyA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1v GLUCOKINASE

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 VAL X 154
LEU X  79
SER X 445
ILE X 126
PHE X  84
 None
 1.32A 1skxA-3h1vX:
undetectable		 1skxA-3h1vX:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lx6 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		5 LEU A 172
PHE A 137
HIS A 128
ARG A 101
PHE A  89
 None
 1.30A 1skxA-3lx6A:
undetectable		 1skxA-3lx6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		5 LEU A 172
PHE A 137
HIS A 128
ARG A 101
PHE A  89
 None
 1.37A 1skxA-3me5A:
undetectable		 1skxA-3me5A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 LEU A 206
SER A 564
GLN A 310
ILE A 194
PHE A 196
 None
 1.23A 1skxA-3mi6A:
undetectable		 1skxA-3mi6A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		5 SER A 378
CYH A 398
GLN A 399
ILE A 428
PHE A 370
 None
 1.41A 1skxA-3qkiA:
undetectable		 1skxA-3qkiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6x OUTER CAPSID PROTEIN
SIGMA-1

(Mammalian
orthoreovirus) 		PF01664
(Reo_sigma1) 		5 VAL A 430
LEU A 426
TRP A 333
ILE A 350
PHE A 370
 None
 1.47A 1skxA-3s6xA:
undetectable		 1skxA-3s6xA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9j F-BOX/LRR-REPEAT
PROTEIN 5

(Homo sapiens) 		PF01814
(Hemerythrin) 		5 LEU A 138
MET A 137
SER A  73
ILE A 150
PHE A 142
 None
 1.48A 1skxA-3u9jA:
undetectable		 1skxA-3u9jA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsb FARNESYLTRANSFERASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF00494
(SQS_PSY) 		5 LEU A  67
PHE A 282
GLN A 287
ILE A 138
PHE A  63
 RWZ  A 502 ( 4.4A)
None
None
None
RWZ  A 502 (-3.8A)
 1.24A 1skxA-3wsbA:
2.0		 1skxA-3wsbA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1

(Homo sapiens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 227
LEU A 298
CYH A 357
GLN A 330
ILE A 294
 None
 1.42A 1skxA-4a35A:
undetectable		 1skxA-4a35A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 VAL A 479
LEU A 578
PHE A 229
CYH A 233
GLN A 238
 None
 1.17A 1skxA-4bocA:
undetectable		 1skxA-4bocA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsd CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		5 VAL A 337
LEU A 371
PHE A 417
ILE A 374
PHE A 370
 None
 1.41A 1skxA-4nsdA:
undetectable		 1skxA-4nsdA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2

(Danio rerio) 		PF00067
(p450) 		5 VAL A 439
PHE A 417
CYH A 358
HIS A 400
ILE A  86
 None
 1.22A 1skxA-4r20A:
undetectable		 1skxA-4r20A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 VAL A 111
LEU A 129
GLN A 117
ILE A 124
PHE A 155
 None
 1.48A 1skxA-4v2dA:
undetectable		 1skxA-4v2dA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF13476
(AAA_23) 		5 VAL A1192
LEU A1223
HIS A1141
ILE A 179
PHE A1227
 None
 1.28A 1skxA-5dacA:
undetectable		 1skxA-5dacA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		5 VAL A 254
SER A 189
PHE A 190
ILE A  82
PHE A  64
 None
 1.44A 1skxA-5jp9A:
undetectable		 1skxA-5jp9A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhr VIRAL ATTACHMENT
PROTEIN SIGMA 1

(Reovirus sp.) 		PF01664
(Reo_sigma1) 		5 VAL A 430
LEU A 426
TRP A 333
ILE A 350
PHE A 370
 None
 1.50A 1skxA-5mhrA:
undetectable		 1skxA-5mhrA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 LEU A 308
PHE A 573
ARG A 503
ILE A 298
PHE A 306
 None
 1.48A 1skxA-5t9gA:
undetectable		 1skxA-5t9gA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 5 LEU A 293
PHE A 273
HIS A 489
ILE A 485
PHE A 289
 None
 1.17A 1skxA-6dk2A:
undetectable		 1skxA-6dk2A:
undetectable