SIMILAR PATTERNS OF AMINO ACIDS FOR 1SH9_B_RITB301_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ag9 | FLAVODOXIN (Escherichiacoli) |
PF00258(Flavodoxin_1) | 5 | ALA A 84ILE A 22ILE A 6GLY A 53ILE A 54 | None | 1.25A | 1sh9A-1ag9A:0.0 | 1sh9A-1ag9A:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ak2 | ADENYLATE KINASEISOENZYME-2 (Bos taurus) |
PF00406(ADK)PF05191(ADK_lid) | 5 | ASP A 179ILE A 140ILE A 137ILE A 186PRO A 25 | NoneNoneNoneNoneSO4 A 301 ( 4.8A) | 1.20A | 1sh9A-1ak2A:0.0 | 1sh9A-1ak2A:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhy | P64K (Neisseriameningitidis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 555ILE A 565ILE A 579GLY A 538ILE A 527 | None | 1.28A | 1sh9A-1bhyA:0.0 | 1sh9A-1bhyA:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhy | P64K (Neisseriameningitidis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 582ILE A 565ILE A 535GLY A 538ILE A 549 | None | 1.38A | 1sh9A-1bhyA:0.0 | 1sh9A-1bhyA:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bkh | MUCONATE LACTONIZINGENZYME (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 11ILE A 9ILE A 108GLY A 49ILE A 307 | None | 1.31A | 1sh9A-1bkhA:0.0 | 1sh9A-1bkhA:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bkh | MUCONATE LACTONIZINGENZYME (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ALA A 51ILE A 71ILE A 108ILE A 48 | None | 0.65A | 1sh9A-1bkhA:0.0 | 1sh9A-1bkhA:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bxz | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | ALA A 206ASP A 205ILE A 175ILE A 215 | None | 0.69A | 1sh9A-1bxzA:undetectable | 1sh9A-1bxzA:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cij | PROTEIN (HALOALKANEDEHALOGENASE) (Xanthobacterautotrophicus) |
PF00561(Abhydrolase_1) | 5 | ALA A 149ASP A 124ILE A 146GLY A 257PRO A 281 | None BR A 401 ( 4.8A)NoneNoneNone | 1.44A | 1sh9A-1cijA:undetectable | 1sh9A-1cijA:15.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e0k | DNA HELICASE (Escherichiavirus T7) |
PF03796(DnaB_C) | 5 | ASP A 526ASP A 297ILE A 518ILE A 295GLY A 301 | None | 1.38A | 1sh9A-1e0kA:undetectable | 1sh9A-1e0kA:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e9y | UREASE SUBUNIT BETA (Helicobacterpylori) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 4 | ALA B 346ILE B 287ILE B 536PRO B 284 | None | 0.70A | 1sh9A-1e9yB:0.0 | 1sh9A-1e9yB:10.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eep | INOSINE5'-MONOPHOSPHATEDEHYDROGENASE (Borreliellaburgdorferi) |
PF00478(IMPDH) | 5 | ASP A 172ILE A 198ILE A 260GLY A 222ILE A 223 | None | 1.10A | 1sh9A-1eepA:undetectable | 1sh9A-1eepA:15.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1foh | PHENOL HYDROXYLASE (Cutaneotrichosporoncutaneum) |
PF01494(FAD_binding_3)PF07976(Phe_hydrox_dim) | 5 | ALA A 358ASP A 357GLY A 14ILE A 12PRO A 144 | NoneFAD A 801 (-2.9A)FAD A 801 (-3.1A)NoneFAD A 801 (-4.3A) | 1.38A | 1sh9A-1fohA:undetectable | 1sh9A-1fohA:9.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1geu | GLUTATHIONEREDUCTASE (Escherichiacoli) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | ILE A 261GLY A 154ILE A 155PRO A 143 | NAD A 452 (-3.9A)NoneNoneNone | 0.62A | 1sh9A-1geuA:undetectable | 1sh9A-1geuA:12.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gkp | HYDANTOINASE (Thermus sp.) |
PF01979(Amidohydro_1) | 5 | ALA A 13ASP A 14ILE A 384GLY A 382ILE A 56 | None | 1.30A | 1sh9A-1gkpA:undetectable | 1sh9A-1gkpA:11.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpr | GLUCOSE PERMEASE (Bacillussubtilis) |
PF00358(PTS_EIIA_1) | 5 | ASP A 28ILE A 23ILE A 144GLY A 42PRO A 18 | None | 1.40A | 1sh9A-1gprA:undetectable | 1sh9A-1gprA:22.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 29GLY A 48PRO A 81 | A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 (-4.1A)A79 A 800 ( 3.4A) | 1.08A | 1sh9A-1hvcA:13.3 | 1sh9A-1hvcA:89.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 29ILE A 47GLY A 49ILE A 50 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A) | 0.40A | 1sh9A-1hvcA:13.3 | 1sh9A-1hvcA:89.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25ALA A 28ASP A 29ILE A 47GLY A 49ILE A 50PRO A 81 | A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A) | 0.49A | 1sh9A-1hvcA:13.3 | 1sh9A-1hvcA:89.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 29ILE A 47GLY A 49PRO A 81 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 ( 3.9A) | 0.40A | 1sh9A-1hvcA:13.3 | 1sh9A-1hvcA:89.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 29ILE A 84GLY A 49ILE A 50 | A79 A 800 (-2.8A)A79 A 800 (-3.6A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A) | 0.68A | 1sh9A-1hvcA:13.3 | 1sh9A-1hvcA:89.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7n | SYNAPSIN II (Rattusnorvegicus) |
PF02078(Synapsin)PF02750(Synapsin_C) | 5 | ALA A 375ASP A 383ILE A 248ILE A 309GLY A 334 | None | 1.24A | 1sh9A-1i7nA:undetectable | 1sh9A-1i7nA:14.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i8d | RIBOFLAVIN SYNTHASE (Escherichiacoli) |
PF00677(Lum_binding) | 5 | ALA A 88ASP A 92ILE A 94GLY A 4PRO A 186 | None | 1.14A | 1sh9A-1i8dA:undetectable | 1sh9A-1i8dA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iwa | RIBULOSE-1,5-BISPHOSPHATECARBOXYLASE/OXYGENASE LARGE SUBUNIT (Galdieriapartita) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | ALA A 417ILE A 413ILE A 407GLY A 405PRO A 410 | None | 1.49A | 1sh9A-1iwaA:undetectable | 1sh9A-1iwaA:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2q | PROTEASOME BETASUBUNIT (Archaeoglobusfulgidus) |
PF00227(Proteasome) | 5 | ALA H 80ILE H 59ILE H 37GLY H 102ILE H 110 | None | 1.43A | 1sh9A-1j2qH:undetectable | 1sh9A-1j2qH:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j31 | HYPOTHETICAL PROTEINPH0642 (Pyrococcushorikoshii) |
PF00795(CN_hydrolase) | 5 | ALA A 223ILE A 230GLY A 5ILE A 193PRO A 41 | None | 1.44A | 1sh9A-1j31A:undetectable | 1sh9A-1j31A:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j31 | HYPOTHETICAL PROTEINPH0642 (Pyrococcushorikoshii) |
PF00795(CN_hydrolase) | 5 | ILE A 193ILE A 212GLY A 231ILE A 230PRO A 41 | None | 1.31A | 1sh9A-1j31A:undetectable | 1sh9A-1j31A:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jcf | RODSHAPE-DETERMININGPROTEIN MREB (Thermotogamaritima) |
PF06723(MreB_Mbl) | 4 | ASP A 72ILE A 32ILE A 41GLY A 39 | None | 0.66A | 1sh9A-1jcfA:undetectable | 1sh9A-1jcfA:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jfd | INORGANICPYROPHOSPHATASE (Escherichiacoli) |
PF00719(Pyrophosphatase) | 5 | ALA A 107ILE A 15ILE A 58GLY A 56ILE A 19 | None | 1.16A | 1sh9A-1jfdA:undetectable | 1sh9A-1jfdA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jfl | ASPARTATE RACEMASE (Pyrococcushorikoshii) |
PF01177(Asp_Glu_race) | 5 | ALA A 75ASP A 76ILE A 78ILE A 22PRO A 81 | None | 1.25A | 1sh9A-1jflA:undetectable | 1sh9A-1jflA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jmc | PROTEIN (REPLICATIONPROTEIN A (RPA)) (Homo sapiens) |
PF01336(tRNA_anti-codon)PF16900(REPA_OB_2) | 5 | ALA A 358ILE A 378ILE A 319GLY A 321ILE A 322 | None | 1.37A | 1sh9A-1jmcA:undetectable | 1sh9A-1jmcA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kb0 | QUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Comamonastestosteroni) |
PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 5 | ALA A 37ILE A 316GLY A 33ILE A 32PRO A 314 | None | 1.26A | 1sh9A-1kb0A:undetectable | 1sh9A-1kb0A:10.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kyh | HYPOTHETICAL 29.9KDA PROTEIN INSIGY-CYDD INTERGENICREGION (Bacillussubtilis) |
PF01256(Carb_kinase) | 5 | ALA A 87ILE A 101ILE A 99ILE A 60PRO A 103 | None | 1.40A | 1sh9A-1kyhA:undetectable | 1sh9A-1kyhA:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kyi | ATP-DEPENDENT HSLPROTEASE ATP-BINDINGSUBUNIT HSLU (Haemophilusinfluenzae) |
PF00004(AAA)PF07724(AAA_2)PF10431(ClpB_D2-small) | 5 | ASP A 428ALA A 429ASP A 405ILE A 421ILE A 407 | None | 1.35A | 1sh9A-1kyiA:undetectable | 1sh9A-1kyiA:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l2q | MONOMETHYLAMINEMETHYLTRANSFERASE (Methanosarcinabarkeri) |
PF05369(MtmB) | 5 | ALA A 268ILE A 263ILE A 301ILE A 271PRO A 298 | None | 1.27A | 1sh9A-1l2qA:undetectable | 1sh9A-1l2qA:11.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lnq | POTASSIUM CHANNELRELATED PROTEIN (Methanothermobacterthermautotrophicus) |
PF02080(TrkA_C)PF02254(TrkA_N)PF07885(Ion_trans_2) | 5 | ALA A 178ILE A 198ILE A 207ILE A 120PRO A 164 | None | 1.12A | 1sh9A-1lnqA:undetectable | 1sh9A-1lnqA:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m53 | ISOMALTULOSESYNTHASE (Klebsiella sp.LX3) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | ASP A 122ILE A 92ILE A 75GLY A 70ILE A 69 | None | 1.18A | 1sh9A-1m53A:undetectable | 1sh9A-1m53A:11.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nf5 | ALPHA-LACTALBUMIN (Mus musculus) |
PF00062(Lys) | 5 | ASP A 78ASP A 57ILE A 75ILE A 55GLY A 51 | None | 1.20A | 1sh9A-1nf5A:undetectable | 1sh9A-1nf5A:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o1y | CONSERVEDHYPOTHETICAL PROTEINTM1158 (Thermotogamaritima) |
PF00117(GATase) | 5 | ALA A 167ILE A 77ILE A 74GLY A 90ILE A 87 | NoneNoneNoneOCS A 88 ( 3.9A)OCS A 88 ( 4.0A) | 1.23A | 1sh9A-1o1yA:undetectable | 1sh9A-1o1yA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1orq | POTASSIUM CHANNEL (Aeropyrumpernix) |
PF00520(Ion_trans) | 5 | ILE C 180ILE C 168GLY C 209ILE C 208PRO C 174 | None | 1.36A | 1sh9A-1orqC:undetectable | 1sh9A-1orqC:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ouv | CONSERVEDHYPOTHETICALSECRETED PROTEIN (Helicobacterpylori) |
PF08238(Sel1) | 5 | ALA A 163ASP A 168ILE A 174GLY A 141ILE A 142 | None | 1.20A | 1sh9A-1ouvA:undetectable | 1sh9A-1ouvA:13.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pox | PYRUVATE OXIDASE (Lactobacillusplantarum) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ALA A 67ASP A 96ILE A 414GLY A 428ILE A 430 | None | 1.26A | 1sh9A-1poxA:undetectable | 1sh9A-1poxA:12.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 4 | ASP A 44ALA A 43ILE A 38ILE A 94 | None | 0.00A | 1sh9A-1q5aA:undetectable | 1sh9A-1q5aA:8.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 4 | ILE A 261ILE A 300GLY A 280ILE A 281 | None | 0.08A | 1sh9A-1q5aA:undetectable | 1sh9A-1q5aA:8.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 4 | ASP A 25ALA A 28ASP A 29PRO A 81 | None | 0.64A | 1sh9A-1q9pA:10.4 | 1sh9A-1q9pA:86.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qqj | FUMARYLACETOACETATEHYDROLASE (Mus musculus) |
PF01557(FAA_hydrolase)PF09298(FAA_hydrolase_N) | 5 | ASP A 126ILE A 259ILE A 166GLY A 256ILE A 173 | CA A 420 (-3.1A)NoneNoneNoneNone | 1.27A | 1sh9A-1qqjA:undetectable | 1sh9A-1qqjA:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qyc | PHENYLCOUMARANBENZYLIC ETHERREDUCTASE PT1 (Pinus taeda) |
PF05368(NmrA) | 5 | ALA A 21ILE A 82ILE A 200GLY A 196ILE A 195 | None | 1.36A | 1sh9A-1qycA:undetectable | 1sh9A-1qycA:14.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rjb | FL CYTOKINE RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 792ILE A 918ILE A 921GLY A 875ILE A 876PRO A 911 | None | 1.11A | 1sh9A-1rjbA:undetectable | 1sh9A-1rjbA:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sg3 | ALLANTOICASE (Saccharomycescerevisiae) |
PF03561(Allantoicase) | 5 | ALA A 199ILE A 262ILE A 259GLY A 342ILE A 195 | None | 1.26A | 1sh9A-1sg3A:undetectable | 1sh9A-1sg3A:14.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 7 | ASP A 25ALA A 28ASP A 29ILE A 32GLY A 49ILE A 50PRO A 81 | None | 0.56A | 1sh9A-1sivA:19.0 | 1sh9A-1sivA:49.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ILE A 32GLY A 48PRO A 81 | None | 1.01A | 1sh9A-1sivA:19.0 | 1sh9A-1sivA:49.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sy7 | CATALASE 1 (Neurosporacrassa) |
PF00199(Catalase)PF01965(DJ-1_PfpI)PF06628(Catalase-rel) | 5 | ALA A 619ASP A 618ILE A 578ILE A 588PRO A 623 | None | 1.21A | 1sh9A-1sy7A:undetectable | 1sh9A-1sy7A:9.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1to6 | GLYCERATE KINASE (Neisseriameningitidis) |
PF02595(Gly_kinase) | 4 | ALA A 243ILE A 259GLY A 250ILE A 143 | SO4 A 373 ( 4.2A)NoneNoneNone | 0.67A | 1sh9A-1to6A:undetectable | 1sh9A-1to6A:14.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqz | NECAP1 (Mus musculus) |
PF07933(DUF1681) | 5 | ALA A 72ILE A 96ILE A 49ILE A 55PRO A 78 | None | 1.16A | 1sh9A-1tqzA:undetectable | 1sh9A-1tqzA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u1h | 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINEMETHYLTRANSFERASE (Arabidopsisthaliana) |
PF01717(Meth_synt_2)PF08267(Meth_synt_1) | 5 | ALA A 665ASP A 664ILE A 660GLY A 690ILE A 726 | None | 1.04A | 1sh9A-1u1hA:undetectable | 1sh9A-1u1hA:9.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u7g | PROBABLE AMMONIUMTRANSPORTER (Escherichiacoli) |
PF00909(Ammonium_transp) | 5 | ILE A 28ILE A 110GLY A 211ILE A 210PRO A 26 | NoneNH3 A 402 ( 4.8A)NoneNoneNone | 1.18A | 1sh9A-1u7gA:undetectable | 1sh9A-1u7gA:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1usv | AHA1 (Saccharomycescerevisiae) |
PF09229(Aha1_N) | 4 | ALA B 33ILE B 127ILE B 75GLY B 77 | None | 0.51A | 1sh9A-1usvB:undetectable | 1sh9A-1usvB:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v77 | HYPOTHETICAL PROTEINPH1877 (Pyrococcushorikoshii) |
PF01876(RNase_P_p30) | 5 | ASP A 180ILE A 199ILE A 182GLY A 185ILE A 188 | None | 1.17A | 1sh9A-1v77A:undetectable | 1sh9A-1v77A:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vl8 | GLUCONATE5-DEHYDROGENASE (Thermotogamaritima) |
PF13561(adh_short_C2) | 4 | ALA A 94ILE A 25ILE A 188ILE A 141 | NAP A 274 (-4.5A)NoneNoneNone | 0.50A | 1sh9A-1vl8A:undetectable | 1sh9A-1vl8A:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vmd | METHYLGLYOXALSYNTHASE (Thermotogamaritima) |
PF02142(MGS) | 4 | ALA A 19ILE A 82ILE A 118ILE A 122 | None | 0.69A | 1sh9A-1vmdA:undetectable | 1sh9A-1vmdA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x1o | NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE (Thermusthermophilus) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 4 | ALA A 107ILE A 47GLY A 57PRO A 76 | None | 0.59A | 1sh9A-1x1oA:undetectable | 1sh9A-1x1oA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x7f | OUTER SURFACEPROTEIN (Bacillus cereus) |
PF05913(DUF871) | 5 | ALA A 27ILE A 23ILE A 34GLY A 6ILE A 225 | None | 1.44A | 1sh9A-1x7fA:undetectable | 1sh9A-1x7fA:12.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xje | RIBONUCLEOTIDEREDUCTASE,B12-DEPENDENT (Thermotogamaritima) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC) | 5 | ASP A 339ALA A 498ASP A 499ILE A 88GLY A 492 | NoneNoneNoneNoneGDP A1002 (-3.8A) | 1.48A | 1sh9A-1xjeA:undetectable | 1sh9A-1xjeA:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xmb | IAA-AMINO ACIDHYDROLASE HOMOLOG 2 (Arabidopsisthaliana) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ALA A 115ASP A 114ILE A 118GLY A 138ILE A 403 | None | 1.40A | 1sh9A-1xmbA:undetectable | 1sh9A-1xmbA:13.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xw8 | UPF0271 PROTEIN YBGL (Escherichiacoli) |
PF03746(LamB_YcsF) | 5 | ALA A 244ASP A 4ILE A 135GLY A 55ILE A 54 | None | 1.18A | 1sh9A-1xw8A:undetectable | 1sh9A-1xw8A:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yw1 | PROTEIN YTNJ (Bacillussubtilis) |
PF00296(Bac_luciferase) | 5 | ALA A 383ILE A 374ILE A 7ILE A 387PRO A 273 | None | 1.37A | 1sh9A-1yw1A:undetectable | 1sh9A-1yw1A:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zos | 5'-METHYLTHIOADENOSINE /S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Streptococcuspneumoniae) |
PF01048(PNP_UDP_1) | 5 | ALA A 56ILE A 178ILE A 6GLY A 49ILE A 50 | NoneNoneNoneNoneMTM A 301 (-4.0A) | 1.20A | 1sh9A-1zosA:undetectable | 1sh9A-1zosA:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b1n | SPE31 (Pachyrhizuserosus) |
PF00112(Peptidase_C1) | 5 | ASP A 156ASP A 146ILE A 202ILE A 200GLY A 152 | NoneNAG A 600 (-3.5A)NoneNoneNone | 1.18A | 1sh9A-2b1nA:undetectable | 1sh9A-2b1nA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cfm | THERMOSTABLE DNALIGASE (Pyrococcusfuriosus) |
PF01068(DNA_ligase_A_M)PF04675(DNA_ligase_A_N)PF04679(DNA_ligase_A_C) | 5 | ASP A 429ILE A 503ILE A 432GLY A 452PRO A 525 | None | 1.41A | 1sh9A-2cfmA:undetectable | 1sh9A-2cfmA:11.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2czr | TBP-INTERACTINGPROTEIN (Thermococcuskodakarensis) |
PF15517(TBPIP_N) | 5 | ASP A 45ILE A 26ILE A 31GLY A 33ILE A 34 | None | 1.26A | 1sh9A-2czrA:undetectable | 1sh9A-2czrA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2db3 | ATP-DEPENDENT RNAHELICASE VASA (Drosophilamelanogaster) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | ALA A 374ILE A 388ILE A 365GLY A 350ILE A 349 | None | 1.26A | 1sh9A-2db3A:undetectable | 1sh9A-2db3A:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e5v | L-ASPARTATE OXIDASE (Sulfurisphaeratokodaii) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | ALA A 204ASP A 340ILE A 202GLY A 380ILE A 381 | None | 1.14A | 1sh9A-2e5vA:undetectable | 1sh9A-2e5vA:11.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eb0 | MANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Methanocaldococcusjannaschii) |
PF01368(DHH)PF02833(DHHA2) | 4 | ALA A 22ILE A 63GLY A 127ILE A 122 | None | 0.70A | 1sh9A-2eb0A:undetectable | 1sh9A-2eb0A:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ecf | DIPEPTIDYL PEPTIDASEIV (Stenotrophomonasmaltophilia) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | ALA A 204ASP A 205ILE A 228ILE A 199GLY A 213 | None | 1.16A | 1sh9A-2ecfA:undetectable | 1sh9A-2ecfA:8.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f1n | CYTOLETHALDISTENDING TOXINSUBUNIT B (Escherichiacoli) |
PF03372(Exo_endo_phos) | 4 | ASP A 107ASP A 130ILE A 125ILE A 39 | None | 0.70A | 1sh9A-2f1nA:undetectable | 1sh9A-2f1nA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fj0 | CARBOXYLIC ESTERHYDROLASE (Manduca sexta) |
PF00135(COesterase) | 5 | ASP A 474ILE A 508ILE A 249GLY A 224ILE A 143 | None | 1.42A | 1sh9A-2fj0A:0.3 | 1sh9A-2fj0A:10.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fli | RIBULOSE-PHOSPHATE3-EPIMERASE (Streptococcuspyogenes) |
PF00834(Ribul_P_3_epim) | 5 | ALA A 7ASP A 65ILE A 25ILE A 10GLY A 198 | NoneNoneNoneNoneDX5 A1901 (-3.4A) | 1.26A | 1sh9A-2fliA:undetectable | 1sh9A-2fliA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 29ILE A 53GLY A 55PRO A 86 | LP1 A 201 (-2.3A)LP1 A 201 (-3.5A)LP1 A 201 (-3.6A)LP1 A 201 (-4.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A) | 0.42A | 1sh9A-2fmbA:15.3 | 1sh9A-2fmbA:27.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gbz | OLIGORIBONUCLEASE (Xanthomonascampestris) |
PF00929(RNase_T) | 5 | ASP A 169ILE A 34ILE A 171GLY A 109ILE A 112 | None | 1.16A | 1sh9A-2gbzA:undetectable | 1sh9A-2gbzA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ggs | 273AA LONGHYPOTHETICALDTDP-4-DEHYDRORHAMNOSE REDUCTASE (Sulfurisphaeratokodaii) |
PF04321(RmlD_sub_bind) | 4 | ALA A 64ILE A 193ILE A 149ILE A 102 | NDP A 900 (-4.3A)NoneNoneNone | 0.67A | 1sh9A-2ggsA:undetectable | 1sh9A-2ggsA:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gpr | GLUCOSE-PERMEASE IIACOMPONENT (Mycoplasmacapricolum) |
PF00358(PTS_EIIA_1) | 5 | ASP A 20ASP A 153ILE A 45ILE A 23GLY A 147 | None | 1.42A | 1sh9A-2gprA:undetectable | 1sh9A-2gprA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i5i | UPF0249 PROTEINEF_3048 (Enterococcusfaecalis) |
PF04794(YdjC) | 4 | ILE A 113ILE A 126GLY A 61ILE A 60 | None | 0.72A | 1sh9A-2i5iA:undetectable | 1sh9A-2i5iA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2idv | EUKARYOTICTRANSLATIONINITIATION FACTOR4E-1 (Triticumaestivum) |
PF01652(IF4E) | 5 | ALA A 165ILE A 121ILE A 194GLY A 181ILE A 180 | None | 1.50A | 1sh9A-2idvA:undetectable | 1sh9A-2idvA:24.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ipx | RRNA2'-O-METHYLTRANSFERASE FIBRILLARIN (Homo sapiens) |
PF01269(Fibrillarin) | 5 | ASP A 232ALA A 162ILE A 158ILE A 181GLY A 183 | None | 1.48A | 1sh9A-2ipxA:undetectable | 1sh9A-2ipxA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isq | CYSTEINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 4 | ALA A 189GLY A 183ILE A 180PRO A 296 | NonePLP A 400 (-3.4A)PLP A 400 (-4.9A)PLP A 400 (-4.0A) | 0.59A | 1sh9A-2isqA:undetectable | 1sh9A-2isqA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ivp | O-SIALOGLYCOPROTEINENDOPEPTIDASE (Pyrococcusabyssi) |
PF00814(Peptidase_M22) | 4 | ASP A 281ILE A 114GLY A 16ILE A 17 | None | 0.72A | 1sh9A-2ivpA:undetectable | 1sh9A-2ivpA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jg5 | FRUCTOSE 1-PHOSPHATEKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 5 | ALA A 253ILE A 2ILE A 130GLY A 39ILE A 40 | None | 1.24A | 1sh9A-2jg5A:undetectable | 1sh9A-2jg5A:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nvv | ACETYL-COAHYDROLASE/TRANSFERASE FAMILY PROTEIN (Porphyromonasgingivalis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 5 | ALA A 429ASP A 430ILE A 423ILE A 390ILE A 362 | ALA A 429 ( 0.0A)ASP A 430 ( 0.5A)ILE A 423 ( 0.7A)ILE A 390 ( 0.7A)ILE A 362 ( 0.4A) | 1.18A | 1sh9A-2nvvA:undetectable | 1sh9A-2nvvA:9.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nx8 | TRNA-SPECIFICADENOSINE DEAMINASE (Streptococcuspyogenes) |
PF14437(MafB19-deam) | 5 | ALA A 146ASP A 148ILE A 92ILE A 111PRO A 94 | None | 1.43A | 1sh9A-2nx8A:undetectable | 1sh9A-2nx8A:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o0x | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF00275(EPSP_synthase) | 5 | ALA A 380ASP A 383ILE A 405GLY A 390ILE A 393 | None | 1.41A | 1sh9A-2o0xA:undetectable | 1sh9A-2o0xA:12.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o0x | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF00275(EPSP_synthase) | 5 | ASP A 403ALA A 380ILE A 405GLY A 390PRO A 5 | None | 1.38A | 1sh9A-2o0xA:undetectable | 1sh9A-2o0xA:12.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ILE A 885ILE A 888GLY A 842ILE A 843PRO A 878 | None | 1.07A | 1sh9A-2ogvA:undetectable | 1sh9A-2ogvA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oz8 | MLL7089 PROTEIN (Mesorhizobiumjaponicum) |
PF13378(MR_MLE_C) | 4 | ASP A 217ILE A 193ILE A 211PRO A 224 | None | 0.68A | 1sh9A-2oz8A:undetectable | 1sh9A-2oz8A:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pcr | INOSITOL-1-MONOPHOSPHATASE (Aquifexaeolicus) |
PF00459(Inositol_P) | 5 | ASP A 89ALA A 190ASP A 193ILE A 215ILE A 241 | None | 1.22A | 1sh9A-2pcrA:undetectable | 1sh9A-2pcrA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pgg | RNA-DIRECTED RNAPOLYMERASE (Infectiousbursal diseasevirus) |
PF04197(Birna_RdRp) | 5 | ASP A 76ILE A 78GLY A 272ILE A 271PRO A 229 | None | 1.04A | 1sh9A-2pggA:undetectable | 1sh9A-2pggA:8.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2phc | UNCHARACTERIZEDPROTEIN PH0987 (Pyrococcushorikoshii) |
PF02682(CT_C_D) | 5 | ILE B 88ILE B 185GLY B 183ILE B 182PRO B 210 | None | 1.46A | 1sh9A-2phcB:undetectable | 1sh9A-2phcB:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pt6 | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 4 | ASP A 196ILE A 145ILE A 153ILE A 163 | S4M A 501 (-2.6A)NoneNoneNone | 0.64A | 1sh9A-2pt6A:undetectable | 1sh9A-2pt6A:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyh | POLY(BETA-D-MANNURONATE) C5 EPIMERASE 4 (Azotobactervinelandii) |
PF12708(Pectate_lyase_3) | 5 | ASP A 13ASP A 17ILE A 22GLY A 9PRO A 40 | None | 1.50A | 1sh9A-2pyhA:undetectable | 1sh9A-2pyhA:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqp | LARGE CAPSID PROTEIN (Providencevirus) |
PF03566(Peptidase_A21) | 5 | ASP A 245ALA A 240ILE A 498ILE A 504GLY A 437 | None | 1.18A | 1sh9A-2qqpA:undetectable | 1sh9A-2qqpA:11.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qxl | HEAT SHOCK PROTEINHOMOLOG SSE1 (Saccharomycescerevisiae) |
PF00012(HSP70) | 5 | ASP A 369ILE A 372ILE A 341GLY A 205PRO A 146 | NoneNoneNoneATP A1002 (-3.5A)None | 1.09A | 1sh9A-2qxlA:undetectable | 1sh9A-2qxlA:10.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r48 | PHOSPHOTRANSFERASESYSTEM (PTS)MANNOSE-SPECIFICENZYME IIBCACOMPONENT (Bacillussubtilis) |
PF02302(PTS_IIB) | 5 | ALA A 26ILE A 34ILE A 60GLY A 85ILE A 86 | None | 1.25A | 1sh9A-2r48A:undetectable | 1sh9A-2r48A:23.15 |