SIMILAR PATTERNS OF AMINO ACIDS FOR 1SH9_B_RITB301
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ag9 | FLAVODOXIN (Escherichiacoli) |
PF00258(Flavodoxin_1) | 5 | ALA A 84ILE A 22ILE A 6GLY A 53ILE A 54 | None | 1.25A | 1sh9A-1ag9A:0.0 | 1sh9A-1ag9A:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ak2 | ADENYLATE KINASEISOENZYME-2 (Bos taurus) |
PF00406(ADK)PF05191(ADK_lid) | 5 | ASP A 179ILE A 140ILE A 137ILE A 186PRO A 25 | NoneNoneNoneNoneSO4 A 301 ( 4.8A) | 1.20A | 1sh9A-1ak2A:0.0 | 1sh9A-1ak2A:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhy | P64K (Neisseriameningitidis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 555ILE A 565ILE A 579GLY A 538ILE A 527 | None | 1.28A | 1sh9A-1bhyA:0.0 | 1sh9A-1bhyA:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhy | P64K (Neisseriameningitidis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 582ILE A 565ILE A 535GLY A 538ILE A 549 | None | 1.38A | 1sh9A-1bhyA:0.0 | 1sh9A-1bhyA:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bkh | MUCONATE LACTONIZINGENZYME (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 11ILE A 9ILE A 108GLY A 49ILE A 307 | None | 1.31A | 1sh9A-1bkhA:0.0 | 1sh9A-1bkhA:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bkh | MUCONATE LACTONIZINGENZYME (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ALA A 51ILE A 71ILE A 108ILE A 48 | None | 0.65A | 1sh9A-1bkhA:0.0 | 1sh9A-1bkhA:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bxz | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | ALA A 206ASP A 205ILE A 175ILE A 215 | None | 0.69A | 1sh9A-1bxzA:undetectable | 1sh9A-1bxzA:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cij | PROTEIN (HALOALKANEDEHALOGENASE) (Xanthobacterautotrophicus) |
PF00561(Abhydrolase_1) | 5 | ALA A 149ASP A 124ILE A 146GLY A 257PRO A 281 | None BR A 401 ( 4.8A)NoneNoneNone | 1.44A | 1sh9A-1cijA:undetectable | 1sh9A-1cijA:15.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e0k | DNA HELICASE (Escherichiavirus T7) |
PF03796(DnaB_C) | 5 | ASP A 526ASP A 297ILE A 518ILE A 295GLY A 301 | None | 1.38A | 1sh9A-1e0kA:undetectable | 1sh9A-1e0kA:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e9y | UREASE SUBUNIT BETA (Helicobacterpylori) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 4 | ALA B 346ILE B 287ILE B 536PRO B 284 | None | 0.70A | 1sh9A-1e9yB:0.0 | 1sh9A-1e9yB:10.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eep | INOSINE5'-MONOPHOSPHATEDEHYDROGENASE (Borreliellaburgdorferi) |
PF00478(IMPDH) | 5 | ASP A 172ILE A 198ILE A 260GLY A 222ILE A 223 | None | 1.10A | 1sh9A-1eepA:undetectable | 1sh9A-1eepA:15.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1foh | PHENOL HYDROXYLASE (Cutaneotrichosporoncutaneum) |
PF01494(FAD_binding_3)PF07976(Phe_hydrox_dim) | 5 | ALA A 358ASP A 357GLY A 14ILE A 12PRO A 144 | NoneFAD A 801 (-2.9A)FAD A 801 (-3.1A)NoneFAD A 801 (-4.3A) | 1.38A | 1sh9A-1fohA:undetectable | 1sh9A-1fohA:9.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1geu | GLUTATHIONEREDUCTASE (Escherichiacoli) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | ILE A 261GLY A 154ILE A 155PRO A 143 | NAD A 452 (-3.9A)NoneNoneNone | 0.62A | 1sh9A-1geuA:undetectable | 1sh9A-1geuA:12.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gkp | HYDANTOINASE (Thermus sp.) |
PF01979(Amidohydro_1) | 5 | ALA A 13ASP A 14ILE A 384GLY A 382ILE A 56 | None | 1.30A | 1sh9A-1gkpA:undetectable | 1sh9A-1gkpA:11.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpr | GLUCOSE PERMEASE (Bacillussubtilis) |
PF00358(PTS_EIIA_1) | 5 | ASP A 28ILE A 23ILE A 144GLY A 42PRO A 18 | None | 1.40A | 1sh9A-1gprA:undetectable | 1sh9A-1gprA:22.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 29GLY A 48PRO A 81 | A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 (-4.1A)A79 A 800 ( 3.4A) | 1.08A | 1sh9A-1hvcA:13.3 | 1sh9A-1hvcA:89.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 29ILE A 47GLY A 49ILE A 50 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A) | 0.40A | 1sh9A-1hvcA:13.3 | 1sh9A-1hvcA:89.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25ALA A 28ASP A 29ILE A 47GLY A 49ILE A 50PRO A 81 | A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A) | 0.49A | 1sh9A-1hvcA:13.3 | 1sh9A-1hvcA:89.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 29ILE A 47GLY A 49PRO A 81 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 ( 3.9A) | 0.40A | 1sh9A-1hvcA:13.3 | 1sh9A-1hvcA:89.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 29ILE A 84GLY A 49ILE A 50 | A79 A 800 (-2.8A)A79 A 800 (-3.6A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A) | 0.68A | 1sh9A-1hvcA:13.3 | 1sh9A-1hvcA:89.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7n | SYNAPSIN II (Rattusnorvegicus) |
PF02078(Synapsin)PF02750(Synapsin_C) | 5 | ALA A 375ASP A 383ILE A 248ILE A 309GLY A 334 | None | 1.24A | 1sh9A-1i7nA:undetectable | 1sh9A-1i7nA:14.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i8d | RIBOFLAVIN SYNTHASE (Escherichiacoli) |
PF00677(Lum_binding) | 5 | ALA A 88ASP A 92ILE A 94GLY A 4PRO A 186 | None | 1.14A | 1sh9A-1i8dA:undetectable | 1sh9A-1i8dA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iwa | RIBULOSE-1,5-BISPHOSPHATECARBOXYLASE/OXYGENASE LARGE SUBUNIT (Galdieriapartita) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | ALA A 417ILE A 413ILE A 407GLY A 405PRO A 410 | None | 1.49A | 1sh9A-1iwaA:undetectable | 1sh9A-1iwaA:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2q | PROTEASOME BETASUBUNIT (Archaeoglobusfulgidus) |
PF00227(Proteasome) | 5 | ALA H 80ILE H 59ILE H 37GLY H 102ILE H 110 | None | 1.43A | 1sh9A-1j2qH:undetectable | 1sh9A-1j2qH:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j31 | HYPOTHETICAL PROTEINPH0642 (Pyrococcushorikoshii) |
PF00795(CN_hydrolase) | 5 | ALA A 223ILE A 230GLY A 5ILE A 193PRO A 41 | None | 1.44A | 1sh9A-1j31A:undetectable | 1sh9A-1j31A:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j31 | HYPOTHETICAL PROTEINPH0642 (Pyrococcushorikoshii) |
PF00795(CN_hydrolase) | 5 | ILE A 193ILE A 212GLY A 231ILE A 230PRO A 41 | None | 1.31A | 1sh9A-1j31A:undetectable | 1sh9A-1j31A:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jcf | RODSHAPE-DETERMININGPROTEIN MREB (Thermotogamaritima) |
PF06723(MreB_Mbl) | 4 | ASP A 72ILE A 32ILE A 41GLY A 39 | None | 0.66A | 1sh9A-1jcfA:undetectable | 1sh9A-1jcfA:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jfd | INORGANICPYROPHOSPHATASE (Escherichiacoli) |
PF00719(Pyrophosphatase) | 5 | ALA A 107ILE A 15ILE A 58GLY A 56ILE A 19 | None | 1.16A | 1sh9A-1jfdA:undetectable | 1sh9A-1jfdA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jfl | ASPARTATE RACEMASE (Pyrococcushorikoshii) |
PF01177(Asp_Glu_race) | 5 | ALA A 75ASP A 76ILE A 78ILE A 22PRO A 81 | None | 1.25A | 1sh9A-1jflA:undetectable | 1sh9A-1jflA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jmc | PROTEIN (REPLICATIONPROTEIN A (RPA)) (Homo sapiens) |
PF01336(tRNA_anti-codon)PF16900(REPA_OB_2) | 5 | ALA A 358ILE A 378ILE A 319GLY A 321ILE A 322 | None | 1.37A | 1sh9A-1jmcA:undetectable | 1sh9A-1jmcA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kb0 | QUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Comamonastestosteroni) |
PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 5 | ALA A 37ILE A 316GLY A 33ILE A 32PRO A 314 | None | 1.26A | 1sh9A-1kb0A:undetectable | 1sh9A-1kb0A:10.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kyh | HYPOTHETICAL 29.9KDA PROTEIN INSIGY-CYDD INTERGENICREGION (Bacillussubtilis) |
PF01256(Carb_kinase) | 5 | ALA A 87ILE A 101ILE A 99ILE A 60PRO A 103 | None | 1.40A | 1sh9A-1kyhA:undetectable | 1sh9A-1kyhA:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kyi | ATP-DEPENDENT HSLPROTEASE ATP-BINDINGSUBUNIT HSLU (Haemophilusinfluenzae) |
PF00004(AAA)PF07724(AAA_2)PF10431(ClpB_D2-small) | 5 | ASP A 428ALA A 429ASP A 405ILE A 421ILE A 407 | None | 1.35A | 1sh9A-1kyiA:undetectable | 1sh9A-1kyiA:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l2q | MONOMETHYLAMINEMETHYLTRANSFERASE (Methanosarcinabarkeri) |
PF05369(MtmB) | 5 | ALA A 268ILE A 263ILE A 301ILE A 271PRO A 298 | None | 1.27A | 1sh9A-1l2qA:undetectable | 1sh9A-1l2qA:11.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lnq | POTASSIUM CHANNELRELATED PROTEIN (Methanothermobacterthermautotrophicus) |
PF02080(TrkA_C)PF02254(TrkA_N)PF07885(Ion_trans_2) | 5 | ALA A 178ILE A 198ILE A 207ILE A 120PRO A 164 | None | 1.12A | 1sh9A-1lnqA:undetectable | 1sh9A-1lnqA:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m53 | ISOMALTULOSESYNTHASE (Klebsiella sp.LX3) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | ASP A 122ILE A 92ILE A 75GLY A 70ILE A 69 | None | 1.18A | 1sh9A-1m53A:undetectable | 1sh9A-1m53A:11.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nf5 | ALPHA-LACTALBUMIN (Mus musculus) |
PF00062(Lys) | 5 | ASP A 78ASP A 57ILE A 75ILE A 55GLY A 51 | None | 1.20A | 1sh9A-1nf5A:undetectable | 1sh9A-1nf5A:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o1y | CONSERVEDHYPOTHETICAL PROTEINTM1158 (Thermotogamaritima) |
PF00117(GATase) | 5 | ALA A 167ILE A 77ILE A 74GLY A 90ILE A 87 | NoneNoneNoneOCS A 88 ( 3.9A)OCS A 88 ( 4.0A) | 1.23A | 1sh9A-1o1yA:undetectable | 1sh9A-1o1yA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1orq | POTASSIUM CHANNEL (Aeropyrumpernix) |
PF00520(Ion_trans) | 5 | ILE C 180ILE C 168GLY C 209ILE C 208PRO C 174 | None | 1.36A | 1sh9A-1orqC:undetectable | 1sh9A-1orqC:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ouv | CONSERVEDHYPOTHETICALSECRETED PROTEIN (Helicobacterpylori) |
PF08238(Sel1) | 5 | ALA A 163ASP A 168ILE A 174GLY A 141ILE A 142 | None | 1.20A | 1sh9A-1ouvA:undetectable | 1sh9A-1ouvA:13.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pox | PYRUVATE OXIDASE (Lactobacillusplantarum) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ALA A 67ASP A 96ILE A 414GLY A 428ILE A 430 | None | 1.26A | 1sh9A-1poxA:undetectable | 1sh9A-1poxA:12.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 4 | ASP A 44ALA A 43ILE A 38ILE A 94 | None | 0.00A | 1sh9A-1q5aA:undetectable | 1sh9A-1q5aA:8.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 4 | ILE A 261ILE A 300GLY A 280ILE A 281 | None | 0.08A | 1sh9A-1q5aA:undetectable | 1sh9A-1q5aA:8.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 4 | ASP A 25ALA A 28ASP A 29PRO A 81 | None | 0.64A | 1sh9A-1q9pA:10.4 | 1sh9A-1q9pA:86.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qqj | FUMARYLACETOACETATEHYDROLASE (Mus musculus) |
PF01557(FAA_hydrolase)PF09298(FAA_hydrolase_N) | 5 | ASP A 126ILE A 259ILE A 166GLY A 256ILE A 173 | CA A 420 (-3.1A)NoneNoneNoneNone | 1.27A | 1sh9A-1qqjA:undetectable | 1sh9A-1qqjA:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qyc | PHENYLCOUMARANBENZYLIC ETHERREDUCTASE PT1 (Pinus taeda) |
PF05368(NmrA) | 5 | ALA A 21ILE A 82ILE A 200GLY A 196ILE A 195 | None | 1.36A | 1sh9A-1qycA:undetectable | 1sh9A-1qycA:14.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rjb | FL CYTOKINE RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 792ILE A 918ILE A 921GLY A 875ILE A 876PRO A 911 | None | 1.11A | 1sh9A-1rjbA:undetectable | 1sh9A-1rjbA:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sg3 | ALLANTOICASE (Saccharomycescerevisiae) |
PF03561(Allantoicase) | 5 | ALA A 199ILE A 262ILE A 259GLY A 342ILE A 195 | None | 1.26A | 1sh9A-1sg3A:undetectable | 1sh9A-1sg3A:14.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 7 | ASP A 25ALA A 28ASP A 29ILE A 32GLY A 49ILE A 50PRO A 81 | None | 0.56A | 1sh9A-1sivA:19.0 | 1sh9A-1sivA:49.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ILE A 32GLY A 48PRO A 81 | None | 1.01A | 1sh9A-1sivA:19.0 | 1sh9A-1sivA:49.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sy7 | CATALASE 1 (Neurosporacrassa) |
PF00199(Catalase)PF01965(DJ-1_PfpI)PF06628(Catalase-rel) | 5 | ALA A 619ASP A 618ILE A 578ILE A 588PRO A 623 | None | 1.21A | 1sh9A-1sy7A:undetectable | 1sh9A-1sy7A:9.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1to6 | GLYCERATE KINASE (Neisseriameningitidis) |
PF02595(Gly_kinase) | 4 | ALA A 243ILE A 259GLY A 250ILE A 143 | SO4 A 373 ( 4.2A)NoneNoneNone | 0.67A | 1sh9A-1to6A:undetectable | 1sh9A-1to6A:14.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqz | NECAP1 (Mus musculus) |
PF07933(DUF1681) | 5 | ALA A 72ILE A 96ILE A 49ILE A 55PRO A 78 | None | 1.16A | 1sh9A-1tqzA:undetectable | 1sh9A-1tqzA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u1h | 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINEMETHYLTRANSFERASE (Arabidopsisthaliana) |
PF01717(Meth_synt_2)PF08267(Meth_synt_1) | 5 | ALA A 665ASP A 664ILE A 660GLY A 690ILE A 726 | None | 1.04A | 1sh9A-1u1hA:undetectable | 1sh9A-1u1hA:9.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u7g | PROBABLE AMMONIUMTRANSPORTER (Escherichiacoli) |
PF00909(Ammonium_transp) | 5 | ILE A 28ILE A 110GLY A 211ILE A 210PRO A 26 | NoneNH3 A 402 ( 4.8A)NoneNoneNone | 1.18A | 1sh9A-1u7gA:undetectable | 1sh9A-1u7gA:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1usv | AHA1 (Saccharomycescerevisiae) |
PF09229(Aha1_N) | 4 | ALA B 33ILE B 127ILE B 75GLY B 77 | None | 0.51A | 1sh9A-1usvB:undetectable | 1sh9A-1usvB:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v77 | HYPOTHETICAL PROTEINPH1877 (Pyrococcushorikoshii) |
PF01876(RNase_P_p30) | 5 | ASP A 180ILE A 199ILE A 182GLY A 185ILE A 188 | None | 1.17A | 1sh9A-1v77A:undetectable | 1sh9A-1v77A:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vl8 | GLUCONATE5-DEHYDROGENASE (Thermotogamaritima) |
PF13561(adh_short_C2) | 4 | ALA A 94ILE A 25ILE A 188ILE A 141 | NAP A 274 (-4.5A)NoneNoneNone | 0.50A | 1sh9A-1vl8A:undetectable | 1sh9A-1vl8A:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vmd | METHYLGLYOXALSYNTHASE (Thermotogamaritima) |
PF02142(MGS) | 4 | ALA A 19ILE A 82ILE A 118ILE A 122 | None | 0.69A | 1sh9A-1vmdA:undetectable | 1sh9A-1vmdA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x1o | NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE (Thermusthermophilus) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 4 | ALA A 107ILE A 47GLY A 57PRO A 76 | None | 0.59A | 1sh9A-1x1oA:undetectable | 1sh9A-1x1oA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x7f | OUTER SURFACEPROTEIN (Bacillus cereus) |
PF05913(DUF871) | 5 | ALA A 27ILE A 23ILE A 34GLY A 6ILE A 225 | None | 1.44A | 1sh9A-1x7fA:undetectable | 1sh9A-1x7fA:12.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xje | RIBONUCLEOTIDEREDUCTASE,B12-DEPENDENT (Thermotogamaritima) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC) | 5 | ASP A 339ALA A 498ASP A 499ILE A 88GLY A 492 | NoneNoneNoneNoneGDP A1002 (-3.8A) | 1.48A | 1sh9A-1xjeA:undetectable | 1sh9A-1xjeA:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xmb | IAA-AMINO ACIDHYDROLASE HOMOLOG 2 (Arabidopsisthaliana) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ALA A 115ASP A 114ILE A 118GLY A 138ILE A 403 | None | 1.40A | 1sh9A-1xmbA:undetectable | 1sh9A-1xmbA:13.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xw8 | UPF0271 PROTEIN YBGL (Escherichiacoli) |
PF03746(LamB_YcsF) | 5 | ALA A 244ASP A 4ILE A 135GLY A 55ILE A 54 | None | 1.18A | 1sh9A-1xw8A:undetectable | 1sh9A-1xw8A:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yw1 | PROTEIN YTNJ (Bacillussubtilis) |
PF00296(Bac_luciferase) | 5 | ALA A 383ILE A 374ILE A 7ILE A 387PRO A 273 | None | 1.37A | 1sh9A-1yw1A:undetectable | 1sh9A-1yw1A:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zos | 5'-METHYLTHIOADENOSINE /S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Streptococcuspneumoniae) |
PF01048(PNP_UDP_1) | 5 | ALA A 56ILE A 178ILE A 6GLY A 49ILE A 50 | NoneNoneNoneNoneMTM A 301 (-4.0A) | 1.20A | 1sh9A-1zosA:undetectable | 1sh9A-1zosA:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b1n | SPE31 (Pachyrhizuserosus) |
PF00112(Peptidase_C1) | 5 | ASP A 156ASP A 146ILE A 202ILE A 200GLY A 152 | NoneNAG A 600 (-3.5A)NoneNoneNone | 1.18A | 1sh9A-2b1nA:undetectable | 1sh9A-2b1nA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cfm | THERMOSTABLE DNALIGASE (Pyrococcusfuriosus) |
PF01068(DNA_ligase_A_M)PF04675(DNA_ligase_A_N)PF04679(DNA_ligase_A_C) | 5 | ASP A 429ILE A 503ILE A 432GLY A 452PRO A 525 | None | 1.41A | 1sh9A-2cfmA:undetectable | 1sh9A-2cfmA:11.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2czr | TBP-INTERACTINGPROTEIN (Thermococcuskodakarensis) |
PF15517(TBPIP_N) | 5 | ASP A 45ILE A 26ILE A 31GLY A 33ILE A 34 | None | 1.26A | 1sh9A-2czrA:undetectable | 1sh9A-2czrA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2db3 | ATP-DEPENDENT RNAHELICASE VASA (Drosophilamelanogaster) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | ALA A 374ILE A 388ILE A 365GLY A 350ILE A 349 | None | 1.26A | 1sh9A-2db3A:undetectable | 1sh9A-2db3A:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e5v | L-ASPARTATE OXIDASE (Sulfurisphaeratokodaii) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | ALA A 204ASP A 340ILE A 202GLY A 380ILE A 381 | None | 1.14A | 1sh9A-2e5vA:undetectable | 1sh9A-2e5vA:11.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eb0 | MANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Methanocaldococcusjannaschii) |
PF01368(DHH)PF02833(DHHA2) | 4 | ALA A 22ILE A 63GLY A 127ILE A 122 | None | 0.70A | 1sh9A-2eb0A:undetectable | 1sh9A-2eb0A:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ecf | DIPEPTIDYL PEPTIDASEIV (Stenotrophomonasmaltophilia) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | ALA A 204ASP A 205ILE A 228ILE A 199GLY A 213 | None | 1.16A | 1sh9A-2ecfA:undetectable | 1sh9A-2ecfA:8.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f1n | CYTOLETHALDISTENDING TOXINSUBUNIT B (Escherichiacoli) |
PF03372(Exo_endo_phos) | 4 | ASP A 107ASP A 130ILE A 125ILE A 39 | None | 0.70A | 1sh9A-2f1nA:undetectable | 1sh9A-2f1nA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fj0 | CARBOXYLIC ESTERHYDROLASE (Manduca sexta) |
PF00135(COesterase) | 5 | ASP A 474ILE A 508ILE A 249GLY A 224ILE A 143 | None | 1.42A | 1sh9A-2fj0A:0.3 | 1sh9A-2fj0A:10.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fli | RIBULOSE-PHOSPHATE3-EPIMERASE (Streptococcuspyogenes) |
PF00834(Ribul_P_3_epim) | 5 | ALA A 7ASP A 65ILE A 25ILE A 10GLY A 198 | NoneNoneNoneNoneDX5 A1901 (-3.4A) | 1.26A | 1sh9A-2fliA:undetectable | 1sh9A-2fliA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 29ILE A 53GLY A 55PRO A 86 | LP1 A 201 (-2.3A)LP1 A 201 (-3.5A)LP1 A 201 (-3.6A)LP1 A 201 (-4.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A) | 0.42A | 1sh9A-2fmbA:15.3 | 1sh9A-2fmbA:27.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gbz | OLIGORIBONUCLEASE (Xanthomonascampestris) |
PF00929(RNase_T) | 5 | ASP A 169ILE A 34ILE A 171GLY A 109ILE A 112 | None | 1.16A | 1sh9A-2gbzA:undetectable | 1sh9A-2gbzA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ggs | 273AA LONGHYPOTHETICALDTDP-4-DEHYDRORHAMNOSE REDUCTASE (Sulfurisphaeratokodaii) |
PF04321(RmlD_sub_bind) | 4 | ALA A 64ILE A 193ILE A 149ILE A 102 | NDP A 900 (-4.3A)NoneNoneNone | 0.67A | 1sh9A-2ggsA:undetectable | 1sh9A-2ggsA:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gpr | GLUCOSE-PERMEASE IIACOMPONENT (Mycoplasmacapricolum) |
PF00358(PTS_EIIA_1) | 5 | ASP A 20ASP A 153ILE A 45ILE A 23GLY A 147 | None | 1.42A | 1sh9A-2gprA:undetectable | 1sh9A-2gprA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i5i | UPF0249 PROTEINEF_3048 (Enterococcusfaecalis) |
PF04794(YdjC) | 4 | ILE A 113ILE A 126GLY A 61ILE A 60 | None | 0.72A | 1sh9A-2i5iA:undetectable | 1sh9A-2i5iA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2idv | EUKARYOTICTRANSLATIONINITIATION FACTOR4E-1 (Triticumaestivum) |
PF01652(IF4E) | 5 | ALA A 165ILE A 121ILE A 194GLY A 181ILE A 180 | None | 1.50A | 1sh9A-2idvA:undetectable | 1sh9A-2idvA:24.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ipx | RRNA2'-O-METHYLTRANSFERASE FIBRILLARIN (Homo sapiens) |
PF01269(Fibrillarin) | 5 | ASP A 232ALA A 162ILE A 158ILE A 181GLY A 183 | None | 1.48A | 1sh9A-2ipxA:undetectable | 1sh9A-2ipxA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isq | CYSTEINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 4 | ALA A 189GLY A 183ILE A 180PRO A 296 | NonePLP A 400 (-3.4A)PLP A 400 (-4.9A)PLP A 400 (-4.0A) | 0.59A | 1sh9A-2isqA:undetectable | 1sh9A-2isqA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ivp | O-SIALOGLYCOPROTEINENDOPEPTIDASE (Pyrococcusabyssi) |
PF00814(Peptidase_M22) | 4 | ASP A 281ILE A 114GLY A 16ILE A 17 | None | 0.72A | 1sh9A-2ivpA:undetectable | 1sh9A-2ivpA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jg5 | FRUCTOSE 1-PHOSPHATEKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 5 | ALA A 253ILE A 2ILE A 130GLY A 39ILE A 40 | None | 1.24A | 1sh9A-2jg5A:undetectable | 1sh9A-2jg5A:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nvv | ACETYL-COAHYDROLASE/TRANSFERASE FAMILY PROTEIN (Porphyromonasgingivalis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 5 | ALA A 429ASP A 430ILE A 423ILE A 390ILE A 362 | ALA A 429 ( 0.0A)ASP A 430 ( 0.5A)ILE A 423 ( 0.7A)ILE A 390 ( 0.7A)ILE A 362 ( 0.4A) | 1.18A | 1sh9A-2nvvA:undetectable | 1sh9A-2nvvA:9.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nx8 | TRNA-SPECIFICADENOSINE DEAMINASE (Streptococcuspyogenes) |
PF14437(MafB19-deam) | 5 | ALA A 146ASP A 148ILE A 92ILE A 111PRO A 94 | None | 1.43A | 1sh9A-2nx8A:undetectable | 1sh9A-2nx8A:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o0x | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF00275(EPSP_synthase) | 5 | ALA A 380ASP A 383ILE A 405GLY A 390ILE A 393 | None | 1.41A | 1sh9A-2o0xA:undetectable | 1sh9A-2o0xA:12.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o0x | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF00275(EPSP_synthase) | 5 | ASP A 403ALA A 380ILE A 405GLY A 390PRO A 5 | None | 1.38A | 1sh9A-2o0xA:undetectable | 1sh9A-2o0xA:12.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ILE A 885ILE A 888GLY A 842ILE A 843PRO A 878 | None | 1.07A | 1sh9A-2ogvA:undetectable | 1sh9A-2ogvA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oz8 | MLL7089 PROTEIN (Mesorhizobiumjaponicum) |
PF13378(MR_MLE_C) | 4 | ASP A 217ILE A 193ILE A 211PRO A 224 | None | 0.68A | 1sh9A-2oz8A:undetectable | 1sh9A-2oz8A:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pcr | INOSITOL-1-MONOPHOSPHATASE (Aquifexaeolicus) |
PF00459(Inositol_P) | 5 | ASP A 89ALA A 190ASP A 193ILE A 215ILE A 241 | None | 1.22A | 1sh9A-2pcrA:undetectable | 1sh9A-2pcrA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pgg | RNA-DIRECTED RNAPOLYMERASE (Infectiousbursal diseasevirus) |
PF04197(Birna_RdRp) | 5 | ASP A 76ILE A 78GLY A 272ILE A 271PRO A 229 | None | 1.04A | 1sh9A-2pggA:undetectable | 1sh9A-2pggA:8.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2phc | UNCHARACTERIZEDPROTEIN PH0987 (Pyrococcushorikoshii) |
PF02682(CT_C_D) | 5 | ILE B 88ILE B 185GLY B 183ILE B 182PRO B 210 | None | 1.46A | 1sh9A-2phcB:undetectable | 1sh9A-2phcB:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pt6 | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 4 | ASP A 196ILE A 145ILE A 153ILE A 163 | S4M A 501 (-2.6A)NoneNoneNone | 0.64A | 1sh9A-2pt6A:undetectable | 1sh9A-2pt6A:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyh | POLY(BETA-D-MANNURONATE) C5 EPIMERASE 4 (Azotobactervinelandii) |
PF12708(Pectate_lyase_3) | 5 | ASP A 13ASP A 17ILE A 22GLY A 9PRO A 40 | None | 1.50A | 1sh9A-2pyhA:undetectable | 1sh9A-2pyhA:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqp | LARGE CAPSID PROTEIN (Providencevirus) |
PF03566(Peptidase_A21) | 5 | ASP A 245ALA A 240ILE A 498ILE A 504GLY A 437 | None | 1.18A | 1sh9A-2qqpA:undetectable | 1sh9A-2qqpA:11.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qxl | HEAT SHOCK PROTEINHOMOLOG SSE1 (Saccharomycescerevisiae) |
PF00012(HSP70) | 5 | ASP A 369ILE A 372ILE A 341GLY A 205PRO A 146 | NoneNoneNoneATP A1002 (-3.5A)None | 1.09A | 1sh9A-2qxlA:undetectable | 1sh9A-2qxlA:10.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r48 | PHOSPHOTRANSFERASESYSTEM (PTS)MANNOSE-SPECIFICENZYME IIBCACOMPONENT (Bacillussubtilis) |
PF02302(PTS_IIB) | 5 | ALA A 26ILE A 34ILE A 60GLY A 85ILE A 86 | None | 1.25A | 1sh9A-2r48A:undetectable | 1sh9A-2r48A:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c30 | CARBAMOYL PHOSPHATESYNTHETASE: LARGESUBUNIT (Escherichiacoli) |
PF02142(MGS)PF02786(CPSase_L_D2)PF02787(CPSase_L_D3) | 5 | GLY A 14ILE A 45ILE A 77ILE A 66ALA A 61 | None | 0.92A | 1sh9B-1c30A:undetectable | 1sh9B-1c30A:7.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d5c | RAB6 GTPASE (Plasmodiumfalciparum) |
PF00071(Ras) | 5 | GLY A 18ASP A 108ILE A 109ILE A 81ALA A 120 | None | 1.03A | 1sh9B-1d5cA:undetectable | 1sh9B-1d5cA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d7b | CELLOBIOSEDEHYDROGENASE (Phanerochaetechrysosporium) |
PF16010(CDH-cyt) | 5 | ASP A 68GLY A 62GLY A 58PRO A 93ALA A 87 | NoneNoneHEM A 401 (-3.5A)HEM A 401 (-4.5A)None | 0.99A | 1sh9B-1d7bA:undetectable | 1sh9B-1d7bA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gkr | NON-ATP DEPENDENTL-SELECTIVEHYDANTOINASE (Paenarthrobacteraurescens) |
PF01979(Amidohydro_1) | 5 | GLY A 49ASP A 21ILE A 22ILE A 17PRO A 54 | None | 1.00A | 1sh9B-1gkrA:undetectable | 1sh9B-1gkrA:12.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8ASP A 25GLY A 27ASP A 30ILE A 47PRO A 81 | A79 A 800 (-3.4A)A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 ( 4.9A)A79 A 800 ( 3.2A)A79 A 800 ( 3.9A) | 1.39A | 1sh9B-1hvcA:13.3 | 1sh9B-1hvcA:89.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8ASP A 25GLY A 27ASP A 30ILE A 47PRO A 81 | A79 A 800 (-3.6A)A79 A 800 (-2.8A)A79 A 800 (-3.0A)A79 A 800 ( 4.7A)A79 A 800 ( 3.4A)A79 A 800 ( 3.4A) | 1.14A | 1sh9B-1hvcA:13.3 | 1sh9B-1hvcA:89.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 30ILE A 47GLY A 49ILE A 50PRO A 81 | A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 ( 4.9A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A) | 0.60A | 1sh9B-1hvcA:13.3 | 1sh9B-1hvcA:89.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 30ILE A 47GLY A 49ILE A 50PRO A 81 | A79 A 800 (-2.8A)A79 A 800 (-3.0A)A79 A 800 ( 4.7A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A) | 0.55A | 1sh9B-1hvcA:13.3 | 1sh9B-1hvcA:89.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lxt | PHOSPHOGLUCOMUTASE(DEPHOSPHO FORM) (Oryctolaguscuniculus) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | GLY A 20ILE A 142ILE A 132GLY A 110ILE A 111 | None | 1.01A | 1sh9B-1lxtA:undetectable | 1sh9B-1lxtA:11.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1omx | ALPHA-1,4-N-ACETYLHEXOSAMINYLTRANSFERASEEXTL2 (Mus musculus) |
PF09258(Glyco_transf_64) | 5 | ILE A 316ILE A 314GLY A 262ILE A 175ALA A 164 | NoneEDO A 401 (-4.7A)NoneNoneNone | 0.93A | 1sh9B-1omxA:undetectable | 1sh9B-1omxA:16.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pox | PYRUVATE OXIDASE (Lactobacillusplantarum) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ARG A 515ILE A 397ILE A 392GLY A 425ILE A 426 | None | 1.06A | 1sh9B-1poxA:undetectable | 1sh9B-1poxA:12.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 30ILE A 32GLY A 49ILE A 50PRO A 81 | None | 0.72A | 1sh9B-1sivA:18.9 | 1sh9B-1sivA:49.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vz8 | ORNITHINEACETYL-TRANSFERASE (Streptomycesclavuligerus) |
PF01960(ArgJ) | 5 | ASP A 365GLY A 272ILE A 326ILE A 310PRO A 335 | None | 1.06A | 1sh9B-1vz8A:undetectable | 1sh9B-1vz8A:12.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zcc | GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE (Agrobacteriumfabrum) |
PF03009(GDPD) | 5 | ASP A 226ILE A 4ILE A 220GLY A 202ALA A 25 | None | 1.07A | 1sh9B-1zccA:undetectable | 1sh9B-1zccA:16.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zkd | DUF185 (Rhodopseudomonaspalustris) |
PF02636(Methyltransf_28) | 5 | GLY A 291ILE A 227ILE A 224GLY A 284ALA A 237 | None | 0.87A | 1sh9B-1zkdA:undetectable | 1sh9B-1zkdA:12.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 5 | ASP A 25GLY A 27ILE A 53GLY A 55PRO A 86 | LP1 A 201 (-2.3A)LP1 A 201 (-3.8A)LP1 A 201 (-4.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A) | 0.36A | 1sh9B-2fmbA:15.3 | 1sh9B-2fmbA:27.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fyw | CONSERVEDHYPOTHETICAL PROTEIN (Streptococcuspneumoniae) |
PF01784(NIF3) | 5 | GLY A 57ILE A 250ILE A 252ILE A 61ALA A 3 | None | 1.00A | 1sh9B-2fywA:undetectable | 1sh9B-2fywA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g3n | ALPHA-GLUCOSIDASE (Sulfolobussolfataricus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 5 | GLY A 115ILE A 102GLY A 66ILE A 65PRO A 528 | None | 0.81A | 1sh9B-2g3nA:undetectable | 1sh9B-2g3nA:9.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6t | CANDIDAPEPSIN-3 (Candidaalbicans) |
PF00026(Asp) | 5 | GLY A 122ASP A 32ILE A 31ILE A 126ILE A 99 | None | 1.08A | 1sh9B-2h6tA:5.4 | 1sh9B-2h6tA:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hj0 | PUTATIVE CITRATELYASE, ALFA SUBUNIT (Streptococcusmutans) |
PF04223(CitF) | 5 | ASP A 402GLY A 149ILE A 432ILE A 497PRO A 434 | None | 1.06A | 1sh9B-2hj0A:undetectable | 1sh9B-2hj0A:11.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hoq | PUTATIVEHAD-HYDROLASE PH1655 (Pyrococcushorikoshii) |
PF13419(HAD_2) | 5 | GLY A 174ILE A 5GLY A 114ILE A 115ALA A 99 | None | 1.02A | 1sh9B-2hoqA:undetectable | 1sh9B-2hoqA:18.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8ASP A 25GLY A 27ASP A 30ILE A 32PRO A 81ALA A 82 | AB1 A 501 ( 4.7A)AB1 A 501 (-2.4A)AB1 A 501 (-3.9A)AB1 A 501 (-3.8A)AB1 A 501 (-4.5A)AB1 A 501 (-4.2A)AB1 A 501 (-3.6A) | 1.25A | 1sh9B-2rkfA:20.7 | 1sh9B-2rkfA:85.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ASP A 30ILE A 32GLY A 49ILE A 50PRO A 81ALA A 82 | AB1 A 501 (-2.4A)AB1 A 501 (-3.9A)AB1 A 501 (-3.8A)AB1 A 501 (-4.5A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 (-3.6A) | 0.54A | 1sh9B-2rkfA:20.7 | 1sh9B-2rkfA:85.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vda | TRANSLOCASE SUBUNITSECA (Escherichiacoli) |
PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 5 | GLY A 573ASP A 568ILE A 567GLY A 455ALA A 507 | None | 1.05A | 1sh9B-2vdaA:undetectable | 1sh9B-2vdaA:7.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] LARGE CHAIN (Azospirillumbrasilense) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | GLY A 729ASP A1180GLY A 753ILE A 754ALA A 733 | None | 1.03A | 1sh9B-2vdcA:undetectable | 1sh9B-2vdcA:6.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y89 | PHOSPHORIBOSYLISOMERASE A (Mycobacteriumtuberculosis) |
PF00977(His_biosynth) | 5 | ASP A 171GLY A 176ASP A 184GLY A 136ILE A 134 | None | 0.99A | 1sh9B-2y89A:undetectable | 1sh9B-2y89A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zyz | PUTATIVEUNCHARACTERIZEDPROTEIN PAE0789TRNA-SPLICINGENDONUCLEASE (Pyrobaculumaerophilum) |
PF01974(tRNA_int_endo)PF02778(tRNA_int_endo_N)no annotation | 5 | GLY A 44ASP B 146ILE B 147ILE B 142ALA A 69 | None | 1.07A | 1sh9B-2zyzA:undetectable | 1sh9B-2zyzA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a1i | AMIDASE (Rhodococcus sp.N-771) |
PF01425(Amidase) | 6 | ARG A 235GLY A 173ASP A 97ILE A 95GLY A 190ILE A 196 | None | 1.27A | 1sh9B-3a1iA:undetectable | 1sh9B-3a1iA:13.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c7t | ECDYSTEROID-PHOSPHATE PHOSPHATASE (Bombyx mori) |
PF00300(His_Phos_1) | 6 | ARG A 73GLY A 299ASP A 265ILE A 262GLY A 259ILE A 258 | NoneNoneNone CL A 332 ( 4.3A)NoneNone | 1.19A | 1sh9B-3c7tA:undetectable | 1sh9B-3c7tA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfh | MANDELATE RACEMASE (VibrionalesbacteriumSWAT-3) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 318ASP A 101GLY A 94PRO A 291ALA A 292 | None | 1.04A | 1sh9B-3dfhA:undetectable | 1sh9B-3dfhA:13.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3euh | CHROMOSOME PARTITIONPROTEIN MUKF (Escherichiacoli) |
PF03882(KicB)PF17192(MukF_M)PF17193(MukF_C) | 5 | ASP A 172ILE A 171ILE A 263GLY A 267ILE A 271 | None | 0.93A | 1sh9B-3euhA:undetectable | 1sh9B-3euhA:10.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fkr | L-2-KETO-3-DEOXYARABONATE DEHYDRATASE (Azospirillumbrasilense) |
PF00701(DHDPS) | 5 | GLY A 222ASP A 208ILE A 183GLY A 205ALA A 165 | NoneNoneKPI A 182 ( 3.8A)NoneNone | 0.95A | 1sh9B-3fkrA:undetectable | 1sh9B-3fkrA:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fo8 | TAIL SHEATH PROTEINGP18 (Escherichiavirus T4) |
PF17481(Phage_sheath_1N) | 5 | GLY D 258ILE D 150ILE D 99GLY D 97ALA D 152 | None | 1.04A | 1sh9B-3fo8D:undetectable | 1sh9B-3fo8D:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3foa | TAIL SHEATH PROTEINGP18 (Escherichiavirus T4) |
PF04984(Phage_sheath_1)PF17481(Phage_sheath_1N) | 5 | GLY A 258ILE A 150ILE A 99GLY A 97ALA A 152 | None | 1.01A | 1sh9B-3foaA:undetectable | 1sh9B-3foaA:12.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ASP A 129GLY A 132ILE A 174PRO A 124ALA A 48 | None | 1.07A | 1sh9B-3g1uA:undetectable | 1sh9B-3g1uA:13.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gb0 | PEPTIDASE T (Bacillus cereus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ASP A 18GLY A 86ILE A 27GLY A 105ILE A 103 | GOL A 376 (-4.8A)NoneNoneNoneNone | 1.06A | 1sh9B-3gb0A:undetectable | 1sh9B-3gb0A:15.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hee | RIBOSE-5-PHOSPHATEISOMERASE (Ruminiclostridiumthermocellum) |
PF02502(LacAB_rpiB) | 5 | GLY A 33ILE A 18ILE A 62GLY A 4ILE A 30 | None | 1.05A | 1sh9B-3heeA:undetectable | 1sh9B-3heeA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn6 | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Borreliellaburgdorferi) |
PF01182(Glucosamine_iso) | 5 | GLY A 38ILE A 202GLY A 137ILE A 144ALA A 235 | None | 1.03A | 1sh9B-3hn6A:undetectable | 1sh9B-3hn6A:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j2n | TAIL SHEATH PROTEINGP18 (Escherichiavirus T4) |
PF04984(Phage_sheath_1)PF17481(Phage_sheath_1N)PF17482(Phage_sheath_1C) | 5 | GLY U 258ILE U 150ILE U 99GLY U 97ALA U 152 | None | 1.01A | 1sh9B-3j2nU:undetectable | 1sh9B-3j2nU:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jtf | MAGNESIUM AND COBALTEFFLUX PROTEIN (Bordetellaparapertussis) |
PF00571(CBS) | 5 | GLY A 180ASP A 120ILE A 122GLY A 184ALA A 149 | None | 1.05A | 1sh9B-3jtfA:undetectable | 1sh9B-3jtfA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2i | ACYL-COENZYME ATHIOESTERASE 4 (Homo sapiens) |
PF04775(Bile_Hydr_Trans)PF08840(BAAT_C) | 5 | GLY A 168ILE A 231GLY A 234ILE A 237ALA A 187 | None | 1.07A | 1sh9B-3k2iA:undetectable | 1sh9B-3k2iA:16.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ASP A 30ILE A 47GLY A 49PRO A 81 | None | 0.51A | 1sh9B-3mwsA:19.7 | 1sh9B-3mwsA:74.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ILE A 47GLY A 49ILE A 50PRO A 81 | None | 0.48A | 1sh9B-3mwsA:19.7 | 1sh9B-3mwsA:74.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ngx | BIFUNCTIONAL PROTEINFOLD (Thermoplasmaacidophilum) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 5 | GLY A 251ILE A 219GLY A 222ILE A 223ALA A 138 | None | 1.05A | 1sh9B-3ngxA:undetectable | 1sh9B-3ngxA:14.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nhv | BH2092 PROTEIN (Bacillushalodurans) |
PF00581(Rhodanese) | 5 | ASP A 53ILE A 65ILE A 123GLY A 121ILE A 120 | None | 1.05A | 1sh9B-3nhvA:undetectable | 1sh9B-3nhvA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o3w | BH2092 PROTEIN (Bacillushalodurans) |
PF00581(Rhodanese) | 5 | ASP A 53ILE A 65ILE A 123GLY A 121ILE A 120 | None | 1.06A | 1sh9B-3o3wA:undetectable | 1sh9B-3o3wA:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3os7 | GALACTOSEMUTAROTASE-LIKEPROTEIN (Clostridiumacetobutylicum) |
PF01263(Aldose_epim) | 5 | GLY A 182ILE A 107GLY A 109ILE A 111PRO A 68 | None | 1.00A | 1sh9B-3os7A:undetectable | 1sh9B-3os7A:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p02 | UNCHARACTERIZEDPROTEIN (Bacteroidesovatus) |
PF14274(DUF4361)PF16343(DUF4973) | 5 | ARG A 221GLY A 184ILE A 197GLY A 314ILE A 293 | EDO A 3 (-4.1A)NoneNoneNoneNone | 0.99A | 1sh9B-3p02A:undetectable | 1sh9B-3p02A:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ph3 | RIBOSE-5-PHOSPHATEISOMERASE (Ruminiclostridiumthermocellum) |
PF02502(LacAB_rpiB) | 5 | GLY A 33ILE A 18ILE A 62GLY A 4ILE A 30 | None | 1.06A | 1sh9B-3ph3A:undetectable | 1sh9B-3ph3A:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q9t | CHOLINEDEHYDROGENASE ANDRELATEDFLAVOPROTEINS (Aspergillusoryzae) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | GLY A 310ASP A 459ILE A 460GLY A 466ALA A 503 | None | 0.97A | 1sh9B-3q9tA:undetectable | 1sh9B-3q9tA:14.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ASP A 30ILE A 47GLY A 49ILE A 50PRO A 81ALA A 82 | 017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-4.2A)None017 A 201 (-4.0A)017 A 201 (-3.3A)NoneSO4 A 101 (-3.5A) | 0.83A | 1sh9B-3t3cA:18.9 | 1sh9B-3t3cA:79.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 30ILE A 32GLY A 49ILE A 50PRO A 81 | 017 A 201 (-2.6A)017 A 201 (-3.6A)017 A 201 (-4.6A)None017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.1A) | 0.49A | 1sh9B-3ttpA:20.2 | 1sh9B-3ttpA:82.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ASP A 30ILE A 32ILE A 47GLY A 49ILE A 50PRO A 81 | 017 A 202 ( 2.5A)017 A 201 ( 3.5A)017 A 201 ( 4.0A)None017 A 202 (-3.6A)017 A 202 (-2.9A)017 A 201 ( 3.5A)017 A 202 (-4.0A) | 0.60A | 1sh9B-3u7sA:20.0 | 1sh9B-3u7sA:84.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vsv | XYLOSIDASE (Thermoanaerobacteriumsaccharolyticum) |
PF13229(Beta_helix) | 5 | GLY A 320ILE A 256ILE A 264GLY A 239ALA A 224 | None | 1.00A | 1sh9B-3vsvA:undetectable | 1sh9B-3vsvA:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zq6 | PUTATIVE ARSENICALPUMP-DRIVING ATPASE (Methanothermobacterthermautotrophicus) |
PF02374(ArsA_ATPase) | 5 | ASP A 254GLY A 255ILE A 251GLY A 20ILE A 19 | None | 1.01A | 1sh9B-3zq6A:undetectable | 1sh9B-3zq6A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a3s | 6-PHOSPHOFRUCTOKINASE (Bacillussubtilis) |
PF00365(PFK) | 5 | ARG A 266GLY A 138ASP A 129GLY A 101ILE A 100 | None | 0.96A | 1sh9B-4a3sA:undetectable | 1sh9B-4a3sA:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aec | CYSTEINE SYNTHASE,MITOCHONDRIAL (Arabidopsisthaliana) |
PF00291(PALP) | 5 | GLY A 270ILE A 157GLY A 292ILE A 294PRO A 404 | NoneNonePLP A 500 (-3.6A)NonePLP A 500 (-4.2A) | 1.06A | 1sh9B-4aecA:undetectable | 1sh9B-4aecA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4esw | PYRIMIDINEBIOSYNTHESIS ENZYMETHI13 (Candidaalbicans) |
PF09084(NMT1) | 5 | GLY A 142ILE A 163GLY A 159ILE A 158ALA A 63 | NoneNoneNoneNoneCIT A 900 (-3.1A) | 1.01A | 1sh9B-4eswA:undetectable | 1sh9B-4eswA:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h1g | MALTOSE BINDINGPROTEIN-CAKAR3 MOTORDOMAIN FUSIONPROTEIN (Candidaalbicans;Escherichiacoli) |
PF00225(Kinesin)PF13416(SBP_bac_8) | 5 | ASP A 568ASP A 529ILE A 530ILE A 528ILE A 488 | None | 0.99A | 1sh9B-4h1gA:undetectable | 1sh9B-4h1gA:8.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hdj | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMB (Pseudomonasaeruginosa) |
PF13360(PQQ_2) | 5 | ASP A 207GLY A 160ILE A 159PRO A 187ALA A 196 | None | 0.86A | 1sh9B-4hdjA:undetectable | 1sh9B-4hdjA:13.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4i | 6-PHOSPHOFRUCTOKINASE (Geobacillusstearothermophilus) |
PF00365(PFK) | 5 | ARG A 266GLY A 138ASP A 129GLY A 101ILE A 100 | None | 0.96A | 1sh9B-4i4iA:undetectable | 1sh9B-4i4iA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j0k | TANNASE (Lactobacillusplantarum) |
no annotation | 5 | GLY A 416ASP A 421ILE A 206ILE A 413ALA A 425 | NoneEGR A 501 (-3.5A)EGR A 501 (-4.0A)NoneNone | 1.00A | 1sh9B-4j0kA:undetectable | 1sh9B-4j0kA:13.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lq0 | LAGLIDADG HOMINGENDONUCLEASE (Leptographiumtruncatum) |
PF00961(LAGLIDADG_1) | 5 | ASP A 53GLY A 262ILE A 60ILE A 15GLY A 176 | None | 1.07A | 1sh9B-4lq0A:undetectable | 1sh9B-4lq0A:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lsw | D-2-HYDROXYACIDDEHYDROGENSASEPROTEIN (Ketogulonicigeniumvulgare) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | GLY A 285ILE A 232ILE A 156GLY A 102ALA A 110 | None | 1.03A | 1sh9B-4lswA:undetectable | 1sh9B-4lswA:14.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lxf | TREHALOSE SYNTHASE (Mycobacteriumtuberculosis) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | ASP A 238ILE A 224GLY A 234ILE A 134ALA A 279 | None | 1.07A | 1sh9B-4lxfA:undetectable | 1sh9B-4lxfA:10.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mfv | BETA-CATENIN-LIKEPROTEIN 1 (Homo sapiens) |
PF08216(CTNNBL) | 5 | ILE A 410ILE A 382GLY A 378ILE A 376ALA A 360 | None | 0.97A | 1sh9B-4mfvA:undetectable | 1sh9B-4mfvA:10.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8ASP A 25GLY A 27ASP A 30ILE A 47PRO A 81 | RIT A 500 (-3.2A)RIT A 500 (-2.4A)RIT A 500 (-3.9A)RIT A 500 (-4.8A)RIT A 500 ( 4.5A)RIT A 500 (-3.9A) | 1.16A | 1sh9B-4njvA:20.1 | 1sh9B-4njvA:86.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ASP A 30ILE A 47GLY A 49PRO A 81 | RIT A 500 (-2.4A)RIT A 500 (-3.9A)RIT A 500 (-4.8A)RIT A 500 ( 4.5A)RIT A 500 (-3.4A)RIT A 500 (-3.9A) | 0.52A | 1sh9B-4njvA:20.1 | 1sh9B-4njvA:86.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ILE A 47GLY A 49ILE A 50PRO A 81 | RIT A 500 (-2.4A)RIT A 500 (-3.9A)RIT A 500 ( 4.5A)RIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-3.9A) | 0.54A | 1sh9B-4njvA:20.1 | 1sh9B-4njvA:86.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o27 | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) |
PF00069(Pkinase) | 5 | ASP B 162GLY B 164ILE B 145GLY B 181ALA B 148 | ADP B 500 ( 3.4A)NoneNoneNoneNone | 1.07A | 1sh9B-4o27B:undetectable | 1sh9B-4o27B:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oje | EFF-1A (Caenorhabditiselegans) |
PF14884(EFF-AFF) | 5 | GLY H 415ASP H 412ILE H 410ILE H 498ALA H 458 | None | 0.95A | 1sh9B-4ojeH:undetectable | 1sh9B-4ojeH:11.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ozy | POLY(BETA-D-MANNURONATE) C5 EPIMERASE (Pseudomonassyringae groupgenomosp. 3) |
PF13229(Beta_helix) | 5 | ASP A 368ILE A 343ILE A 342GLY A 364ILE A 381 | None | 1.07A | 1sh9B-4ozyA:undetectable | 1sh9B-4ozyA:14.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pka | PATATIN-17 (Solanumcardiophyllum) |
PF01734(Patatin) | 5 | GLY X 261ILE X 34GLY X 38ILE X 39ALA X 45 | NoneNoneMIS X 77 ( 3.4A)NoneNone | 1.00A | 1sh9B-4pkaX:undetectable | 1sh9B-4pkaX:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qi3 | CELLOBIOSEDEHYDROGENASE (Crassicarponhotsonii) |
PF16010(CDH-cyt) | 5 | GLY A 72ILE A 80GLY A 67PRO A 102ALA A 96 | NoneNoneHEM A 401 (-3.5A)HEM A 401 ( 4.7A)None | 1.07A | 1sh9B-4qi3A:undetectable | 1sh9B-4qi3A:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qiw | DNA-DIRECTED RNAPOLYMERASE (Thermococcuskodakarensis) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | GLY A 511ASP A 506ILE A 504GLY A 754ALA A 502 | None | 1.06A | 1sh9B-4qiwA:undetectable | 1sh9B-4qiwA:7.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rk9 | CARBOHYDRATE ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN MSME (Bacilluslicheniformis) |
PF01547(SBP_bac_1) | 5 | ILE A 303GLY A 143ILE A 144PRO A 300ALA A 293 | None | 1.04A | 1sh9B-4rk9A:undetectable | 1sh9B-4rk9A:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u1r | ATP-DEPENDENT6-PHOSPHOFRUCTOKINASE, PLATELET TYPE (Homo sapiens) |
PF00365(PFK) | 5 | ARG A 324GLY A 186ASP A 177GLY A 126ILE A 125 | NoneNoneATP A 801 ( 4.8A)NoneNone | 1.01A | 1sh9B-4u1rA:undetectable | 1sh9B-4u1rA:9.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u8g | PUTATIVEUNCHARACTERIZEDPROTEIN GBS1891 (Streptococcusagalactiae) |
PF13561(adh_short_C2) | 5 | ASP A 71ILE A 78GLY A 21PRO A 126ALA A 125 | None | 1.05A | 1sh9B-4u8gA:undetectable | 1sh9B-4u8gA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uow | OBSCURINTITIN (Homo sapiens) |
PF07679(I-set) | 5 | GLY 1 89ILE 0 14ILE 0 94ILE 0 65ALA 1 93 | None | 1.07A | 1sh9B-4uow1:undetectable | 1sh9B-4uow1:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y0w | YEAZ (Pseudomonasaeruginosa) |
PF00814(Peptidase_M22) | 5 | ASP A 8GLY A 63GLY A 67ILE A 116ALA A 13 | NA A 302 (-3.6A)NoneNoneNone NA A 302 (-4.1A) | 0.93A | 1sh9B-4y0wA:undetectable | 1sh9B-4y0wA:16.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ym3 | GALECTIN-4 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 5 | ARG A 306GLY A 281ASP A 296ILE A 208ALA A 234 | None | 0.82A | 1sh9B-4ym3A:undetectable | 1sh9B-4ym3A:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yrp | HISTIDYL-TRNASYNTHETASE (Trypanosomacruzi) |
PF03129(HGTP_anticodon)PF13393(tRNA-synt_His) | 5 | GLY A 361ILE A 367GLY A 326ILE A 207ALA A 194 | HIS A 501 (-3.8A)NoneNoneNoneNone | 1.04A | 1sh9B-4yrpA:undetectable | 1sh9B-4yrpA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d6n | ACYL-COA SYNTHASE (Mycolicibacteriumsmegmatis) |
PF00501(AMP-binding) | 5 | GLY A 393ILE A 339ILE A 317GLY A 313ALA A 309 | None | 1.01A | 1sh9B-5d6nA:undetectable | 1sh9B-5d6nA:12.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d9a | POLYMERASE ACIDICPROTEIN (Influenza Cvirus) |
PF00603(Flu_PA) | 5 | GLY A 293ASP A 288ILE A 287ILE A 324ILE A 298 | None | 1.02A | 1sh9B-5d9aA:undetectable | 1sh9B-5d9aA:9.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gkx | UNCHARACTERIZEDPROTEIN (Thermococcusonnurineus) |
PF14336(DUF4392) | 6 | ASP A 235GLY A 236ILE A 225ILE A 228GLY A 232ALA A 242 | None | 1.42A | 1sh9B-5gkxA:undetectable | 1sh9B-5gkxA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h6s | AMIDASE (Microbacteriumsp. HM58-2) |
PF01425(Amidase) | 6 | ARG A 225GLY A 157ASP A 81ILE A 79GLY A 174ILE A 180 | None | 1.11A | 1sh9B-5h6sA:undetectable | 1sh9B-5h6sA:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ibz | UNCHARACTERIZEDPROTEIN (unculturedorganism) |
PF04199(Cyclase) | 5 | ASP A 266GLY A 223GLY A 246ILE A 196ALA A 264 | None | 0.80A | 1sh9B-5ibzA:undetectable | 1sh9B-5ibzA:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5im3 | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (Pseudomonasaeruginosa) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF03477(ATP-cone) | 5 | ARG A 632GLY A 659ILE A 697ILE A 607ALA A 699 | None | 0.98A | 1sh9B-5im3A:undetectable | 1sh9B-5im3A:7.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odr | METHYL-VIOLOGENREDUCINGHYDROGENASE, SUBUNITAMETHYL-VIOLOGENREDUCINGHYDROGENASE, SUBUNITG (Methanothermococcusthermolithotrophicus) |
PF00374(NiFeSe_Hases)PF01058(Oxidored_q6) | 5 | GLY F 14ILE F 60GLY F 62ILE E 17PRO F 374 | NoneNoneNoneNoneNFU F 501 (-3.5A) | 0.93A | 1sh9B-5odrF:undetectable | 1sh9B-5odrF:12.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8ASP A 25GLY A 27ASP A 30ILE A 47PRO A 81 | None | 1.11A | 1sh9B-5t2zA:20.9 | 1sh9B-5t2zA:83.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 30ILE A 47GLY A 49ILE A 50PRO A 81 | None | 0.42A | 1sh9B-5t2zA:20.9 | 1sh9B-5t2zA:83.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTENFORMYLMETHANOFURANDEHYDROGENASESUBUNIT B (Methanothermobactersp. CaT2) |
PF00384(Molybdopterin) | 5 | ARG B 288ASP B 18ILE B 19GLY B 38ILE B 37 | NoneNoneNoneSF4 B 501 ( 4.0A)SF4 B 501 (-4.5A) | 1.05A | 1sh9B-5t5iB:undetectable | 1sh9B-5t5iB:12.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5twb | FERREDOXIN--NADPREDUCTASE (Staphylococcusaureus) |
PF07992(Pyr_redox_2) | 5 | GLY A 9ILE A 111ILE A 286GLY A 116ILE A 117 | FAD A 401 ( 4.7A)NoneNoneFAD A 401 (-4.0A)FAD A 401 (-4.8A) | 0.70A | 1sh9B-5twbA:undetectable | 1sh9B-5twbA:16.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tzq | BCL-2-LIKE PROTEINFPV039 (Fowlpox virus) |
PF00452(Bcl-2) | 5 | ASP A 119ILE A 117ILE A 113GLY A 111ALA A 14 | None | 0.99A | 1sh9B-5tzqA:undetectable | 1sh9B-5tzqA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vbf | NAD-DEPENDENTSUCCINATE-SEMIALDEHYDE DEHYDROGENASE (Burkholderiavietnamiensis) |
PF00171(Aldedh) | 5 | GLY A 212ASP A 50ILE A 16ILE A 190ALA A 152 | None | 1.00A | 1sh9B-5vbfA:undetectable | 1sh9B-5vbfA:11.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vj7 | OXIDOREDUCTASE (Pyrococcusfuriosus) |
PF07992(Pyr_redox_2)PF14691(Fer4_20) | 5 | GLY A 264ILE A 357GLY A 259ILE A 260PRO A 353 | None | 0.93A | 1sh9B-5vj7A:undetectable | 1sh9B-5vj7A:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xoe | ATP-DEPENDENT6-PHOSPHOFRUCTOKINASE (Staphylococcusaureus) |
no annotation | 5 | ARG A 268GLY A 140ASP A 129GLY A 101ILE A 100 | None | 1.05A | 1sh9B-5xoeA:undetectable | 1sh9B-5xoeA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xsx | CHITINASE (Thermococcuschitonophagus) |
no annotation | 5 | ASP A 487ILE A 488GLY A 484ILE A 483ALA A 530 | GOL A1004 (-3.5A)NoneNoneNoneNone | 1.01A | 1sh9B-5xsxA:undetectable | 1sh9B-5xsxA:26.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fea | NITROGENASE PROTEINALPHA CHAIN (Azotobactervinelandii) |
no annotation | 5 | ASP A 384GLY A 385ILE A 34ILE A 12ALA A 38 | None | 1.06A | 1sh9B-6feaA:undetectable | 1sh9B-6feaA:25.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 30ILE A 32GLY A 49ILE A 50PRO A 81 | NIU A 100 (-2.8A)NIU A 100 (-4.5A)NoneNoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)None | 0.82A | 1sh9B-6upjA:18.7 | 1sh9B-6upjA:48.48 |