SIMILAR PATTERNS OF AMINO ACIDS FOR 1SGU_B_MK1B2632_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
154l GOOSE LYSOZYME

(Anser anser)
PF01464
(SLT)
5 ASP A 161
ALA A 170
ILE A  11
ILE A 127
ALA A 158
None
1.30A 1sguA-154lA:
undetectable
1sguA-154lA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)


(Amycolatopsis
mediterranei)
PF01041
(DegT_DnrJ_EryC1)
5 ASP A 159
ALA A 161
GLY A 195
GLY A 196
ALA A  94
PLP  A 389 (-2.8A)
PLP  A 389 (-3.5A)
None
None
None
1.00A 1sguA-1b9hA:
0.0
1sguA-1b9hA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdm MALATE DEHYDROGENASE

(Thermus
thermophilus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ALA A 139
ILE A 107
GLY A 105
PRO A 131
ALA A 132
None
NAX  A 334 ( 4.0A)
None
None
NAX  A 334 ( 4.0A)
1.20A 1sguA-1bdmA:
0.0
1sguA-1bdmA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A 540
GLY A 539
GLY A 538
ILE A 527
ALA A 583
None
1.27A 1sguA-1bhyA:
undetectable
1sguA-1bhyA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)


(Lactobacillus
sp. 30A)
PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C)
5 ALA A 712
ILE A 688
GLY A 687
ILE A 683
PRO A 659
None
1.31A 1sguA-1c4kA:
undetectable
1sguA-1c4kA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7g TYROSINE
PHENOL-LYASE


(Pantoea
agglomerans)
PF01212
(Beta_elim_lyase)
5 ALA A 301
ILE A 263
GLY A 264
GLY A 255
ALA A  55
None
1.06A 1sguA-1c7gA:
0.0
1sguA-1c7gA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)


(Bacillus
subtilis)
PF00135
(COesterase)
5 ALA A 211
GLY A 216
GLY A 192
PRO A 288
ALA A 200
None
1.27A 1sguA-1c7jA:
0.0
1sguA-1c7jA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea)
PF00135
(COesterase)
5 ALA A   4
ILE A 193
GLY A 198
GLY A 197
ALA A  22
None
None
None
None
PO4  A 601 (-2.9A)
1.18A 1sguA-1cleA:
0.0
1sguA-1cleA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2k CHITINASE 1

(Coccidioides
immitis)
PF00704
(Glyco_hydro_18)
5 GLY A 130
GLY A 129
ILE A 128
PRO A 140
ALA A 141
None
1.08A 1sguA-1d2kA:
undetectable
1sguA-1d2kA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)


(Homo sapiens)
PF00156
(Pribosyltran)
5 ALA A  68
ILE A 116
GLY A 117
GLY A 118
ILE A  99
PRP  A 312 (-3.2A)
None
None
None
None
1.22A 1sguA-1d6nA:
undetectable
1sguA-1d6nA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)


(Aspergillus
nidulans)
PF01761
(DHQ_synthase)
5 ILE A 167
GLY A 151
GLY A 150
ILE A 149
ALA A 256
None
0.84A 1sguA-1dqsA:
undetectable
1sguA-1dqsA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 208
ILE A 211
GLY A 184
GLY A 183
ILE A 182
None
1.22A 1sguA-1ebdA:
undetectable
1sguA-1ebdA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A 189
GLY A 184
GLY A 183
ILE A 182
ALA A 169
None
1.21A 1sguA-1ebdA:
undetectable
1sguA-1ebdA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A 211
GLY A 184
GLY A 183
ILE A 182
ALA A 256
None
1.29A 1sguA-1ebdA:
undetectable
1sguA-1ebdA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)


(Paracoccus
denitrificans)
PF01012
(ETF)
5 ALA B 208
ILE B  63
GLY B  64
PRO B 217
ALA B 216
None
AMP  A 400 (-4.2A)
None
None
None
1.05A 1sguA-1efpB:
undetectable
1sguA-1efpB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em2 MLN64 PROTEIN

(Homo sapiens)
PF01852
(START)
5 ALA A 247
ILE A 365
GLY A 364
GLY A 386
ILE A 405
None
1.13A 1sguA-1em2A:
undetectable
1sguA-1em2A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1es6 MATRIX PROTEIN VP40

(Ebola virus sp.)
PF07447
(VP40)
5 ASP A 296
ILE A 258
GLY A 260
ILE A 261
PRO A 317
None
1.29A 1sguA-1es6A:
undetectable
1sguA-1es6A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)


(Sus scrofa)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
5 ILE A 191
GLY A 192
GLY A 193
ILE A 159
ALA A 182
None
CA  A 995 (-4.3A)
CA  A 995 ( 4.9A)
None
None
1.31A 1sguA-1fblA:
undetectable
1sguA-1fblA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkk FK506 BINDING
PROTEIN


(Bos taurus)
PF00254
(FKBP_C)
5 ALA A  72
GLY A  10
GLY A  69
PRO A  16
ALA A  64
None
1.10A 1sguA-1fkkA:
undetectable
1sguA-1fkkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ftf ACYL CARRIER PROTEIN
SYNTHASE


(Streptococcus
pneumoniae)
PF01648
(ACPS)
5 ALA A1061
ILE A1070
GLY A1069
PRO A1094
ALA A1093
None
1.01A 1sguA-1ftfA:
undetectable
1sguA-1ftfA:
24.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
7 ASP A  25
ALA A  28
ILE A  47
GLY A  48
GLY A  49
ILE A  50
PRO A  81
A79  A 800 (-2.7A)
A79  A 800 (-3.1A)
A79  A 800 ( 3.2A)
A79  A 800 (-3.6A)
A79  A 800 ( 3.7A)
A79  A 800 (-3.8A)
A79  A 800 ( 3.9A)
0.55A 1sguA-1hvcA:
13.4
1sguA-1hvcA:
89.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
7 ASP A  25
ALA A  28
ILE A  47
GLY A  48
GLY A  49
ILE A  50
PRO A  81
A79  A 800 (-2.8A)
A79  A 800 (-3.2A)
A79  A 800 ( 3.4A)
A79  A 800 (-4.1A)
A79  A 800 (-3.4A)
A79  A 800 ( 4.0A)
A79  A 800 ( 3.4A)
0.50A 1sguA-1hvcA:
13.4
1sguA-1hvcA:
89.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ILE A  50
GLY A  51
GLY A  51
ILE A  54
ALA A  28
A79  A 800 ( 4.0A)
None
None
None
A79  A 800 (-3.2A)
1.10A 1sguA-1hvcA:
13.4
1sguA-1hvcA:
89.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ILE A  50
GLY A  51
GLY A  51
ILE A  54
ALA A  28
A79  A 800 (-3.8A)
None
None
None
A79  A 800 (-3.1A)
1.16A 1sguA-1hvcA:
13.4
1sguA-1hvcA:
89.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE


(Curvularia
inaequalis)
PF01569
(PAP2)
5 ASP A 432
ALA A 479
GLY A 408
GLY A 409
ILE A 557
None
1.32A 1sguA-1iduA:
undetectable
1sguA-1iduA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT


(Klebsiella
pneumoniae)
PF02286
(Dehydratase_LU)
5 ILE A 474
GLY A 471
GLY A 216
PRO A 181
ALA A 180
None
1.32A 1sguA-1iwpA:
undetectable
1sguA-1iwpA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME BETA
SUBUNIT


(Archaeoglobus
fulgidus)
PF00227
(Proteasome)
5 ALA H  38
ILE H 101
GLY H 102
GLY H 103
ILE H 104
None
0.81A 1sguA-1j2qH:
undetectable
1sguA-1j2qH:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME BETA
SUBUNIT


(Archaeoglobus
fulgidus)
PF00227
(Proteasome)
5 ILE H 104
GLY H 103
GLY H 102
ILE H 101
PRO H  74
None
1.20A 1sguA-1j2qH:
undetectable
1sguA-1j2qH:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF00465
(Fe-ADH)
5 ASP A 100
ILE A 113
GLY A  92
PRO A 125
ALA A 124
None
1.21A 1sguA-1jpuA:
undetectable
1sguA-1jpuA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1


(Homo sapiens)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 ALA A 200
GLY A 210
GLY A 211
ILE A 212
ALA A 170
None
1.13A 1sguA-1l1fA:
undetectable
1sguA-1l1fA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi)
PF00921
(Lipoprotein_2)
5 ALA A 290
GLY A 166
ILE A 171
PRO A 255
ALA A 283
None
1.08A 1sguA-1l8wA:
undetectable
1sguA-1l8wA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE


(Salmonella
enterica)
PF00155
(Aminotran_1_2)
5 ALA A 339
GLY A   9
GLY A  10
PRO A 221
ALA A 219
None
TPO  A 990 (-3.5A)
None
None
None
0.96A 1sguA-1lc7A:
undetectable
1sguA-1lc7A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6d CATHEPSIN F

(Homo sapiens)
PF00112
(Peptidase_C1)
5 ASP A  57
ALA A  74
ILE A 107
GLY A  79
ALA A  27
None
1.30A 1sguA-1m6dA:
undetectable
1sguA-1m6dA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A


(Rattus
norvegicus)
PF01593
(Amino_oxidase)
5 ALA A  29
GLY A  21
GLY A  20
ILE A  19
ALA A 455
None
FAD  A 652 ( 4.3A)
FAD  A 652 (-3.3A)
FAD  A 652 (-4.8A)
None
1.16A 1sguA-1o5wA:
undetectable
1sguA-1o5wA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A


(Rattus
norvegicus)
PF01593
(Amino_oxidase)
5 ALA A  29
GLY A  22
GLY A  20
ILE A  19
ALA A 455
None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.3A)
FAD  A 652 (-4.8A)
None
1.28A 1sguA-1o5wA:
undetectable
1sguA-1o5wA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica)
PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M)
5 ALA A  28
GLY A  19
GLY A  20
ILE A  46
ALA A  53
None
ACT  A 504 (-3.3A)
ACT  A 504 (-4.3A)
None
None
0.94A 1sguA-1pjqA:
undetectable
1sguA-1pjqA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)


(Streptomyces
venezuelae)
PF07931
(CPT)
5 ALA A  70
GLY A  52
GLY A  53
ILE A  54
PRO A  44
None
1.23A 1sguA-1qhxA:
undetectable
1sguA-1qhxA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT


(Wolinella
succinogenes)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 ALA A  20
GLY A  13
GLY A  12
ILE A  11
ALA A 395
None
FAD  A1656 (-3.4A)
FAD  A1656 (-3.3A)
None
None
0.86A 1sguA-1qlbA:
undetectable
1sguA-1qlbA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9h FK506 BINDING
PROTEIN FAMILY


(Caenorhabditis
elegans)
PF00254
(FKBP_C)
5 ALA A  86
GLY A  24
GLY A  83
PRO A  30
ALA A  78
None
1.23A 1sguA-1r9hA:
undetectable
1sguA-1r9hA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 792
ILE A 921
GLY A 875
ILE A 876
PRO A 911
None
1.19A 1sguA-1rjbA:
undetectable
1sguA-1rjbA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rr9 ATP-DEPENDENT
PROTEASE LA


(Escherichia
coli)
PF05362
(Lon_C)
5 ALA A 602
ILE A 716
GLY A 717
GLY A 718
ALA A 726
None
1.19A 1sguA-1rr9A:
undetectable
1sguA-1rr9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6r BETA-LACTAMASE

(Enterobacter
cloacae)
PF00144
(Beta-lactamase)
5 ILE A  78
GLY A  75
GLY A 251
ILE A 252
PRO A 307
None
1.21A 1sguA-1s6rA:
undetectable
1sguA-1s6rA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT


(Thauera
aromatica)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
5 ASP A  19
ILE A 481
GLY A 243
GLY A 242
PRO A 239
None
PCD  A1920 (-4.2A)
PCD  A1920 (-3.4A)
None
None
1.16A 1sguA-1sb3A:
undetectable
1sguA-1sb3A:
9.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus)
PF00077
(RVP)
6 ASP A  25
ALA A  28
GLY A  48
GLY A  49
ILE A  50
PRO A  81
None
0.54A 1sguA-1sivA:
19.0
1sguA-1sivA:
49.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq1 CHORISMATE SYNTHASE

(Campylobacter
jejuni)
PF01264
(Chorismate_synt)
5 ILE A 287
GLY A 246
GLY A 248
ILE A 249
ALA A 206
None
1.15A 1sguA-1sq1A:
undetectable
1sguA-1sq1A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szp DNA REPAIR PROTEIN
RAD51


(Saccharomyces
cerevisiae)
PF08423
(Rad51)
PF14520
(HHH_5)
5 ASP A 168
ILE A 158
GLY A 211
GLY A 210
ILE A 208
None
1.28A 1sguA-1szpA:
undetectable
1sguA-1szpA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE


(Escherichia
coli)
PF00291
(PALP)
PF00585
(Thr_dehydrat_C)
5 ALA A 211
GLY A 191
GLY A 190
ILE A 247
ALA A 214
None
PLP  A 962 (-3.1A)
PLP  A 962 (-3.5A)
None
None
1.05A 1sguA-1tdjA:
undetectable
1sguA-1tdjA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis)
PF02595
(Gly_kinase)
5 ALA A 241
ILE A 224
GLY A 139
GLY A 140
ILE A 143
None
1.03A 1sguA-1to6A:
undetectable
1sguA-1to6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ton TONIN

(Rattus rattus)
PF00089
(Trypsin)
5 ALA A 138
GLY A  43
GLY A 196
ILE A 212
ALA A 226
None
1.28A 1sguA-1tonA:
undetectable
1sguA-1tonA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1


(Streptomyces
coelicolor)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 ALA A 107
ILE A 351
GLY A 352
GLY A 172
ALA A  73
None
1.11A 1sguA-1tqyA:
undetectable
1sguA-1tqyA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Toxoplasma
gondii)
no annotation 5 ALA D 218
ILE D 229
GLY D 232
ILE D  52
PRO D 165
None
URF  D 999 (-4.0A)
None
None
None
1.12A 1sguA-1upfD:
undetectable
1sguA-1upfD:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE


(Saccharomyces
cerevisiae)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A  21
GLY A  13
GLY A  12
ILE A  11
ALA A 343
None
FAD  A 480 ( 4.8A)
FAD  A 480 (-3.1A)
None
None
1.23A 1sguA-1v59A:
undetectable
1sguA-1v59A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Thermus
thermophilus)
PF01070
(FMN_dh)
5 ASP A 210
ALA A 212
GLY A 216
GLY A 264
ALA A  65
None
FMN  A 501 ( 3.8A)
FMN  A 501 ( 4.0A)
FMN  A 501 (-4.3A)
FMN  A 501 (-3.3A)
1.13A 1sguA-1vcgA:
undetectable
1sguA-1vcgA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcj NEURAMINIDASE

(Influenza B
virus)
PF00064
(Neur)
5 ALA A 121
GLY A 412
ILE A 445
PRO A 118
ALA A 131
None
1.09A 1sguA-1vcjA:
undetectable
1sguA-1vcjA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE


(Pyrobaculum
aerophilum)
PF01791
(DeoC)
5 ALA A 142
GLY A 109
ILE A 105
PRO A  88
ALA A  87
None
1.19A 1sguA-1vcvA:
undetectable
1sguA-1vcvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkq GUANINE DEAMINASE

(Bacillus
subtilis)
PF00383
(dCMP_cyt_deam_1)
5 ALA A  52
ILE A  22
GLY A  23
GLY A  24
ALA A  28
None
1.09A 1sguA-1wkqA:
undetectable
1sguA-1wkqA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhk PUTATIVE PROTEASE LA
HOMOLOG


(Methanocaldococcus
jannaschii)
PF05362
(Lon_C)
5 ALA A 466
ILE A 587
GLY A 588
GLY A 589
ALA A 573
None
1.24A 1sguA-1xhkA:
undetectable
1sguA-1xhkA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhk PUTATIVE PROTEASE LA
HOMOLOG


(Methanocaldococcus
jannaschii)
PF05362
(Lon_C)
5 ALA A 466
ILE A 587
GLY A 588
GLY A 589
ALA A 597
None
1.10A 1sguA-1xhkA:
undetectable
1sguA-1xhkA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y89 DEVB PROTEIN

(Vibrio cholerae)
PF01182
(Glucosamine_iso)
5 ASP A  68
ALA A 146
GLY A 143
GLY A 140
PRO A 167
PO4  A 239 ( 4.9A)
None
None
PO4  A 241 (-3.3A)
None
1.26A 1sguA-1y89A:
undetectable
1sguA-1y89A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE


(Streptococcus
pyogenes)
PF00478
(IMPDH)
PF00571
(CBS)
5 ASP A  54
ILE A 309
GLY A 422
GLY A 394
ALA A  52
None
None
IMP  A 500 (-3.1A)
IMP  A 500 (-3.0A)
None
1.03A 1sguA-1zfjA:
undetectable
1sguA-1zfjA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198


(Pseudomonas
aeruginosa)
PF02016
(Peptidase_S66)
5 ALA A 137
GLY A 134
GLY A 113
ILE A 117
ALA A  19
None
1.07A 1sguA-1zl0A:
undetectable
1sguA-1zl0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anl PLASMEPSIN IV

(Plasmodium
malariae)
PF00026
(Asp)
5 ASP A 316
ILE A 173
GLY A 172
GLY A 171
ILE A 149
None
1.16A 1sguA-2anlA:
6.4
1sguA-2anlA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE


(Bacillus
circulans)
PF01041
(DegT_DnrJ_EryC1)
5 ASP A 163
ALA A 165
GLY A 199
GLY A 200
ALA A  98
PMP  A1416 (-2.8A)
PMP  A1416 (-3.5A)
None
None
None
0.97A 1sguA-2c81A:
undetectable
1sguA-2c81A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE


(Bacillus
circulans)
PF01041
(DegT_DnrJ_EryC1)
5 ASP A 163
ALA A 165
GLY A 200
ILE A 202
ALA A  98
PMP  A1416 (-2.8A)
PMP  A1416 (-3.5A)
None
None
None
1.30A 1sguA-2c81A:
undetectable
1sguA-2c81A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE


(Bacillus
circulans)
PF01041
(DegT_DnrJ_EryC1)
5 ASP A 163
GLY A 199
GLY A 200
ILE A 201
ALA A  73
PMP  A1416 (-2.8A)
None
None
None
None
1.18A 1sguA-2c81A:
undetectable
1sguA-2c81A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb4 MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus)
no annotation 5 ASP A 273
ILE A 139
GLY A 202
GLY A 203
ILE A 204
None
1.30A 1sguA-2cb4A:
undetectable
1sguA-2cb4A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE


(Pseudomonas
stutzeri)
PF00202
(Aminotran_3)
5 ASP A 241
GLY A 120
GLY A 278
ILE A 279
ALA A 129
None
1.27A 1sguA-2cy8A:
undetectable
1sguA-2cy8A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE


(Pseudomonas
stutzeri)
PF00202
(Aminotran_3)
5 ASP A 241
GLY A 277
GLY A 278
ILE A 279
ALA A 129
None
1.12A 1sguA-2cy8A:
undetectable
1sguA-2cy8A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE


(Luciola
cruciata)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 ALA A  68
ILE A 100
GLY A  97
ILE A  92
ALA A 180
CSO  A  64 ( 3.4A)
None
None
None
CSO  A  64 ( 3.8A)
1.09A 1sguA-2d1qA:
undetectable
1sguA-2d1qA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT


(Pseudomonas
fragi)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 ALA A  69
ILE A  66
GLY A 118
GLY A 116
ALA A  92
None
1.29A 1sguA-2d3tA:
undetectable
1sguA-2d3tA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195


(Thermus
thermophilus)
PF03746
(LamB_YcsF)
5 ASP A  21
GLY A  39
GLY A  40
ILE A  45
ALA A  31
None
1.13A 1sguA-2dfaA:
undetectable
1sguA-2dfaA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egu CYSTEINE SYNTHASE

(Geobacillus
kaustophilus)
PF00291
(PALP)
5 ALA A 251
GLY A 264
GLY A 263
ILE A 261
ALA A 274
None
1.21A 1sguA-2eguA:
undetectable
1sguA-2eguA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4e ATFKBP42

(Arabidopsis
thaliana)
PF00254
(FKBP_C)
5 ALA A 122
GLY A  59
GLY A 119
PRO A  64
ALA A 114
None
1.25A 1sguA-2f4eA:
undetectable
1sguA-2f4eA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5x BUGD

(Bordetella
pertussis)
PF03401
(TctC)
5 ALA A 138
GLY A  48
GLY A  47
ILE A 135
ALA A 131
ASP  A 901 (-3.5A)
None
None
None
None
1.10A 1sguA-2f5xA:
undetectable
1sguA-2f5xA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B


(Homo sapiens)
PF00378
(ECH_1)
5 ALA A 308
ILE A 392
GLY A 393
GLY A 395
ILE A 398
None
1.27A 1sguA-2fbmA:
undetectable
1sguA-2fbmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B


(Homo sapiens)
PF00378
(ECH_1)
5 ALA A 308
ILE A 392
GLY A 393
ILE A 398
ALA A 336
None
1.25A 1sguA-2fbmA:
undetectable
1sguA-2fbmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A


(Archaeoglobus
fulgidus)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 ALA A  37
GLY A  30
GLY A  29
ILE A  28
ALA A 441
None
FAD  A1000 (-4.3A)
FAD  A1000 (-3.3A)
None
None
0.98A 1sguA-2fjaA:
undetectable
1sguA-2fjaA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A


(Archaeoglobus
fulgidus)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 ALA A  38
GLY A  30
GLY A  29
ILE A  28
ALA A 459
None
FAD  A1000 (-4.3A)
FAD  A1000 (-3.3A)
None
None
1.31A 1sguA-2fjaA:
undetectable
1sguA-2fjaA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE


(Equine
infectious
anemia virus)
PF00077
(RVP)
6 ASP A  25
ALA A  28
ILE A  53
GLY A  54
GLY A  55
PRO A  86
LP1  A 201 (-2.3A)
LP1  A 201 (-3.5A)
LP1  A 201 (-4.6A)
LP1  A 201 (-3.6A)
LP1  A 201 (-3.4A)
LP1  A 201 (-3.9A)
0.38A 1sguA-2fmbA:
15.2
1sguA-2fmbA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2


(Homo sapiens)
PF00378
(ECH_1)
5 ALA A  28
ILE A 112
GLY A 113
GLY A 115
ILE A 118
None
1.22A 1sguA-2fw2A:
undetectable
1sguA-2fw2A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2


(Homo sapiens)
PF00378
(ECH_1)
5 ALA A  28
ILE A 112
GLY A 113
ILE A 118
ALA A  56
None
1.23A 1sguA-2fw2A:
undetectable
1sguA-2fw2A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
5 ILE A 102
GLY A  68
GLY A  66
ILE A  65
PRO A 528
None
1.18A 1sguA-2g3nA:
undetectable
1sguA-2g3nA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Staphylococcus
aureus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 ILE A 106
GLY A 190
GLY A 237
ILE A 349
ALA A 194
None
1.30A 1sguA-2gqdA:
undetectable
1sguA-2gqdA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1t HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa)
PF06475
(Glycolipid_bind)
5 ASP A 151
ALA A 152
ILE A 115
GLY A 175
ILE A 178
None
1.32A 1sguA-2h1tA:
undetectable
1sguA-2h1tA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdw HYPOTHETICAL PROTEIN
PA2218


(Pseudomonas
aeruginosa)
PF02129
(Peptidase_S15)
5 ALA A 188
GLY A 182
GLY A 177
ILE A 176
ALA A 158
None
1.23A 1sguA-2hdwA:
undetectable
1sguA-2hdwA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfs MEVALONATE KINASE,
PUTATIVE


(Leishmania
major)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 ILE A 165
GLY A 163
GLY A  37
ILE A  38
ALA A 113
None
1.30A 1sguA-2hfsA:
undetectable
1sguA-2hfsA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Pyrococcus
furiosus)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 ALA A 295
GLY A 289
GLY A 135
ILE A 136
ALA A 150
None
PCP  A 392 (-3.3A)
None
None
None
1.32A 1sguA-2i14A:
undetectable
1sguA-2i14A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idc ANTI-SILENCING
PROTEIN 1 AND
HISTONE H3 CHIMERA


(Saccharomyces
cerevisiae)
PF04729
(ASF1_hist_chap)
5 ASP A  20
ALA A  16
ILE A 139
ILE A 135
PRO A  79
None
1.20A 1sguA-2idcA:
undetectable
1sguA-2idcA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if4 ATFKBP42

(Arabidopsis
thaliana)
PF00254
(FKBP_C)
PF13181
(TPR_8)
5 ALA A 122
GLY A  59
GLY A 119
PRO A  64
ALA A 114
None
1.22A 1sguA-2if4A:
undetectable
1sguA-2if4A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1


(Anopheles
gambiae)
PF00481
(PP2C)
5 ALA A 169
ILE A 271
GLY A 270
GLY A 269
ILE A 267
None
1.13A 1sguA-2irmA:
undetectable
1sguA-2irmA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4r EXOPOLYPHOSPHATASE

(Aquifex
aeolicus)
PF02541
(Ppx-GppA)
5 ASP A 141
ILE A 165
GLY A 166
GLY A 145
PRO A 116
None
1.27A 1sguA-2j4rA:
undetectable
1sguA-2j4rA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7v TLL2115 PROTEIN

(Synechococcus
elongatus)
PF13354
(Beta-lactamase2)
5 ALA A 244
GLY A  52
GLY A  37
PRO A  58
ALA A  59
None
1.24A 1sguA-2j7vA:
undetectable
1sguA-2j7vA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE


(Desulfovibrio
desulfuricans)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
5 ILE A 123
GLY A 127
GLY A 126
ILE A 389
ALA A 358
None
1.29A 1sguA-2jirA:
undetectable
1sguA-2jirA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A


(Methanocaldococcus
jannaschii)
PF00117
(GATase)
5 ASP A 106
ALA A 140
ILE A 175
GLY A 172
PRO A 116
None
1.25A 1sguA-2lxnA:
undetectable
1sguA-2lxnA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae)
PF01041
(DegT_DnrJ_EryC1)
5 ASP A 164
ALA A 166
GLY A 201
GLY A 202
ALA A  99
PGU  A1020 (-2.6A)
PGU  A1020 (-3.5A)
None
None
None
1.00A 1sguA-2ogaA:
undetectable
1sguA-2ogaA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqc PENICILLIN V ACYLASE

(Bacillus
subtilis)
PF02275
(CBAH)
5 ALA A  53
ILE A  71
GLY A  70
GLY A  56
ILE A  30
None
0.96A 1sguA-2oqcA:
undetectable
1sguA-2oqcA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz4 FAB FRAGMENT, HEAVY
CHAIN
INTERCELLULAR
ADHESION MOLECULE 1


(Homo sapiens;
Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
no annotation
5 ASP A 375
ILE A 414
GLY A 415
GLY H  57
ILE H  51
None
1.25A 1sguA-2oz4A:
undetectable
1sguA-2oz4A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po3 4-DEHYDRASE

(Streptomyces
venezuelae)
PF01041
(DegT_DnrJ_EryC1)
5 ASP A1171
ALA A1173
GLY A1207
GLY A1208
ALA A1106
T4K  A1500 ( 2.7A)
T4K  A1500 ( 3.4A)
None
None
None
0.98A 1sguA-2po3A:
undetectable
1sguA-2po3A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B


(Methanosarcina
mazei)
PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans)
5 ALA B 424
ILE B 320
GLY B 321
PRO B 230
ALA B 231
None
1.19A 1sguA-2q2eB:
undetectable
1sguA-2q2eB:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC


(Escherichia
coli)
PF01032
(FecCD)
5 ALA A 148
ILE A 128
GLY A  92
GLY A 153
ILE A 154
None
1.05A 1sguA-2qi9A:
undetectable
1sguA-2qi9A:
18.64