SIMILAR PATTERNS OF AMINO ACIDS FOR 1SGU_B_MK1B2632_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 154l | GOOSE LYSOZYME (Anser anser) |
PF01464(SLT) | 5 | ASP A 161ALA A 170ILE A 11ILE A 127ALA A 158 | None | 1.30A | 1sguA-154lA:undetectable | 1sguA-154lA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b9h | PROTEIN(3-AMINO-5-HYDROXYBENZOIC ACID SYNTHASE) (Amycolatopsismediterranei) |
PF01041(DegT_DnrJ_EryC1) | 5 | ASP A 159ALA A 161GLY A 195GLY A 196ALA A 94 | PLP A 389 (-2.8A)PLP A 389 (-3.5A)NoneNoneNone | 1.00A | 1sguA-1b9hA:0.0 | 1sguA-1b9hA:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bdm | MALATE DEHYDROGENASE (Thermusthermophilus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ALA A 139ILE A 107GLY A 105PRO A 131ALA A 132 | NoneNAX A 334 ( 4.0A)NoneNoneNAX A 334 ( 4.0A) | 1.20A | 1sguA-1bdmA:0.0 | 1sguA-1bdmA:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhy | P64K (Neisseriameningitidis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 540GLY A 539GLY A 538ILE A 527ALA A 583 | None | 1.27A | 1sguA-1bhyA:undetectable | 1sguA-1bhyA:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c4k | PROTEIN (ORNITHINEDECARBOXYLASE) (Lactobacillussp. 30A) |
PF01276(OKR_DC_1)PF03709(OKR_DC_1_N)PF03711(OKR_DC_1_C) | 5 | ALA A 712ILE A 688GLY A 687ILE A 683PRO A 659 | None | 1.31A | 1sguA-1c4kA:undetectable | 1sguA-1c4kA:10.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c7g | TYROSINEPHENOL-LYASE (Pantoeaagglomerans) |
PF01212(Beta_elim_lyase) | 5 | ALA A 301ILE A 263GLY A 264GLY A 255ALA A 55 | None | 1.06A | 1sguA-1c7gA:0.0 | 1sguA-1c7gA:13.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c7j | PROTEIN(PARA-NITROBENZYLESTERASE) (Bacillussubtilis) |
PF00135(COesterase) | 5 | ALA A 211GLY A 216GLY A 192PRO A 288ALA A 200 | None | 1.27A | 1sguA-1c7jA:0.0 | 1sguA-1c7jA:16.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cle | CHOLESTEROL ESTERASE ([Candida]cylindracea) |
PF00135(COesterase) | 5 | ALA A 4ILE A 193GLY A 198GLY A 197ALA A 22 | NoneNoneNoneNonePO4 A 601 (-2.9A) | 1.18A | 1sguA-1cleA:0.0 | 1sguA-1cleA:10.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d2k | CHITINASE 1 (Coccidioidesimmitis) |
PF00704(Glyco_hydro_18) | 5 | GLY A 130GLY A 129ILE A 128PRO A 140ALA A 141 | None | 1.08A | 1sguA-1d2kA:undetectable | 1sguA-1d2kA:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d6n | PROTEIN(HYPOXANTHINE-GUANINEPHOSPHORIBOSYLTRANSFERASE) (Homo sapiens) |
PF00156(Pribosyltran) | 5 | ALA A 68ILE A 116GLY A 117GLY A 118ILE A 99 | PRP A 312 (-3.2A)NoneNoneNoneNone | 1.22A | 1sguA-1d6nA:undetectable | 1sguA-1d6nA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dqs | PROTEIN(3-DEHYDROQUINATESYNTHASE) (Aspergillusnidulans) |
PF01761(DHQ_synthase) | 5 | ILE A 167GLY A 151GLY A 150ILE A 149ALA A 256 | None | 0.84A | 1sguA-1dqsA:undetectable | 1sguA-1dqsA:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ebd | DIHYDROLIPOAMIDEDEHYDROGENASE (Geobacillusstearothermophilus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 208ILE A 211GLY A 184GLY A 183ILE A 182 | None | 1.22A | 1sguA-1ebdA:undetectable | 1sguA-1ebdA:12.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ebd | DIHYDROLIPOAMIDEDEHYDROGENASE (Geobacillusstearothermophilus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 189GLY A 184GLY A 183ILE A 182ALA A 169 | None | 1.21A | 1sguA-1ebdA:undetectable | 1sguA-1ebdA:12.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ebd | DIHYDROLIPOAMIDEDEHYDROGENASE (Geobacillusstearothermophilus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 211GLY A 184GLY A 183ILE A 182ALA A 256 | None | 1.29A | 1sguA-1ebdA:undetectable | 1sguA-1ebdA:12.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1efp | PROTEIN (ELECTRONTRANSFERFLAVOPROTEIN) (Paracoccusdenitrificans) |
PF01012(ETF) | 5 | ALA B 208ILE B 63GLY B 64PRO B 217ALA B 216 | NoneAMP A 400 (-4.2A)NoneNoneNone | 1.05A | 1sguA-1efpB:undetectable | 1sguA-1efpB:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1em2 | MLN64 PROTEIN (Homo sapiens) |
PF01852(START) | 5 | ALA A 247ILE A 365GLY A 364GLY A 386ILE A 405 | None | 1.13A | 1sguA-1em2A:undetectable | 1sguA-1em2A:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1es6 | MATRIX PROTEIN VP40 (Ebola virus sp.) |
PF07447(VP40) | 5 | ASP A 296ILE A 258GLY A 260ILE A 261PRO A 317 | None | 1.29A | 1sguA-1es6A:undetectable | 1sguA-1es6A:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fbl | FIBROBLAST(INTERSTITIAL)COLLAGENASE (MMP-1) (Sus scrofa) |
PF00045(Hemopexin)PF00413(Peptidase_M10) | 5 | ILE A 191GLY A 192GLY A 193ILE A 159ALA A 182 | None CA A 995 (-4.3A) CA A 995 ( 4.9A)NoneNone | 1.31A | 1sguA-1fblA:undetectable | 1sguA-1fblA:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fkk | FK506 BINDINGPROTEIN (Bos taurus) |
PF00254(FKBP_C) | 5 | ALA A 72GLY A 10GLY A 69PRO A 16ALA A 64 | None | 1.10A | 1sguA-1fkkA:undetectable | 1sguA-1fkkA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ftf | ACYL CARRIER PROTEINSYNTHASE (Streptococcuspneumoniae) |
PF01648(ACPS) | 5 | ALA A1061ILE A1070GLY A1069PRO A1094ALA A1093 | None | 1.01A | 1sguA-1ftfA:undetectable | 1sguA-1ftfA:24.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25ALA A 28ILE A 47GLY A 48GLY A 49ILE A 50PRO A 81 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 ( 3.2A)A79 A 800 (-3.6A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A) | 0.55A | 1sguA-1hvcA:13.4 | 1sguA-1hvcA:89.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25ALA A 28ILE A 47GLY A 48GLY A 49ILE A 50PRO A 81 | A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 ( 3.4A)A79 A 800 (-4.1A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A) | 0.50A | 1sguA-1hvcA:13.4 | 1sguA-1hvcA:89.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ILE A 50GLY A 51GLY A 51ILE A 54ALA A 28 | A79 A 800 ( 4.0A)NoneNoneNoneA79 A 800 (-3.2A) | 1.10A | 1sguA-1hvcA:13.4 | 1sguA-1hvcA:89.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ILE A 50GLY A 51GLY A 51ILE A 54ALA A 28 | A79 A 800 (-3.8A)NoneNoneNoneA79 A 800 (-3.1A) | 1.16A | 1sguA-1hvcA:13.4 | 1sguA-1hvcA:89.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1idu | VANADIUMCHLOROPEROXIDASE (Curvulariainaequalis) |
PF01569(PAP2) | 5 | ASP A 432ALA A 479GLY A 408GLY A 409ILE A 557 | None | 1.32A | 1sguA-1iduA:undetectable | 1sguA-1iduA:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iwp | GLYCEROL DEHYDRATASEALPHA SUBUNIT (Klebsiellapneumoniae) |
PF02286(Dehydratase_LU) | 5 | ILE A 474GLY A 471GLY A 216PRO A 181ALA A 180 | None | 1.32A | 1sguA-1iwpA:undetectable | 1sguA-1iwpA:9.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2q | PROTEASOME BETASUBUNIT (Archaeoglobusfulgidus) |
PF00227(Proteasome) | 5 | ALA H 38ILE H 101GLY H 102GLY H 103ILE H 104 | None | 0.81A | 1sguA-1j2qH:undetectable | 1sguA-1j2qH:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2q | PROTEASOME BETASUBUNIT (Archaeoglobusfulgidus) |
PF00227(Proteasome) | 5 | ILE H 104GLY H 103GLY H 102ILE H 101PRO H 74 | None | 1.20A | 1sguA-1j2qH:undetectable | 1sguA-1j2qH:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jpu | GLYCEROLDEHYDROGENASE (Geobacillusstearothermophilus) |
PF00465(Fe-ADH) | 5 | ASP A 100ILE A 113GLY A 92PRO A 125ALA A 124 | None | 1.21A | 1sguA-1jpuA:undetectable | 1sguA-1jpuA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1f | GLUTAMATEDEHYDROGENASE 1 (Homo sapiens) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | ALA A 200GLY A 210GLY A 211ILE A 212ALA A 170 | None | 1.13A | 1sguA-1l1fA:undetectable | 1sguA-1l1fA:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l8w | VLSE1 (Borreliellaburgdorferi) |
PF00921(Lipoprotein_2) | 5 | ALA A 290GLY A 166ILE A 171PRO A 255ALA A 283 | None | 1.08A | 1sguA-1l8wA:undetectable | 1sguA-1l8wA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lc7 | L-THREONINE-O-3-PHOSPHATE DECARBOXYLASE (Salmonellaenterica) |
PF00155(Aminotran_1_2) | 5 | ALA A 339GLY A 9GLY A 10PRO A 221ALA A 219 | NoneTPO A 990 (-3.5A)NoneNoneNone | 0.96A | 1sguA-1lc7A:undetectable | 1sguA-1lc7A:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m6d | CATHEPSIN F (Homo sapiens) |
PF00112(Peptidase_C1) | 5 | ASP A 57ALA A 74ILE A 107GLY A 79ALA A 27 | None | 1.30A | 1sguA-1m6dA:undetectable | 1sguA-1m6dA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5w | AMINE OXIDASE[FLAVIN-CONTAINING]A (Rattusnorvegicus) |
PF01593(Amino_oxidase) | 5 | ALA A 29GLY A 21GLY A 20ILE A 19ALA A 455 | NoneFAD A 652 ( 4.3A)FAD A 652 (-3.3A)FAD A 652 (-4.8A)None | 1.16A | 1sguA-1o5wA:undetectable | 1sguA-1o5wA:11.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5w | AMINE OXIDASE[FLAVIN-CONTAINING]A (Rattusnorvegicus) |
PF01593(Amino_oxidase) | 5 | ALA A 29GLY A 22GLY A 20ILE A 19ALA A 455 | NoneFAD A 652 (-3.4A)FAD A 652 (-3.3A)FAD A 652 (-4.8A)None | 1.28A | 1sguA-1o5wA:undetectable | 1sguA-1o5wA:11.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pjq | SIROHEME SYNTHASE (Salmonellaenterica) |
PF00590(TP_methylase)PF10414(CysG_dimeriser)PF13241(NAD_binding_7)PF14824(Sirohm_synth_M) | 5 | ALA A 28GLY A 19GLY A 20ILE A 46ALA A 53 | NoneACT A 504 (-3.3A)ACT A 504 (-4.3A)NoneNone | 0.94A | 1sguA-1pjqA:undetectable | 1sguA-1pjqA:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhx | PROTEIN(CHLORAMPHENICOLPHOSPHOTRANSFERASE) (Streptomycesvenezuelae) |
PF07931(CPT) | 5 | ALA A 70GLY A 52GLY A 53ILE A 54PRO A 44 | None | 1.23A | 1sguA-1qhxA:undetectable | 1sguA-1qhxA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qlb | FUMARATE REDUCTASEFLAVOPROTEIN SUBUNIT (Wolinellasuccinogenes) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | ALA A 20GLY A 13GLY A 12ILE A 11ALA A 395 | NoneFAD A1656 (-3.4A)FAD A1656 (-3.3A)NoneNone | 0.86A | 1sguA-1qlbA:undetectable | 1sguA-1qlbA:9.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r9h | FK506 BINDINGPROTEIN FAMILY (Caenorhabditiselegans) |
PF00254(FKBP_C) | 5 | ALA A 86GLY A 24GLY A 83PRO A 30ALA A 78 | None | 1.23A | 1sguA-1r9hA:undetectable | 1sguA-1r9hA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rjb | FL CYTOKINE RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 792ILE A 921GLY A 875ILE A 876PRO A 911 | None | 1.19A | 1sguA-1rjbA:undetectable | 1sguA-1rjbA:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rr9 | ATP-DEPENDENTPROTEASE LA (Escherichiacoli) |
PF05362(Lon_C) | 5 | ALA A 602ILE A 716GLY A 717GLY A 718ALA A 726 | None | 1.19A | 1sguA-1rr9A:undetectable | 1sguA-1rr9A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s6r | BETA-LACTAMASE (Enterobactercloacae) |
PF00144(Beta-lactamase) | 5 | ILE A 78GLY A 75GLY A 251ILE A 252PRO A 307 | None | 1.21A | 1sguA-1s6rA:undetectable | 1sguA-1s6rA:15.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sb3 | 4-HYDROXYBENZOYL-COAREDUCTASE ALPHASUBUNIT (Thaueraaromatica) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | ASP A 19ILE A 481GLY A 243GLY A 242PRO A 239 | NonePCD A1920 (-4.2A)PCD A1920 (-3.4A)NoneNone | 1.16A | 1sguA-1sb3A:undetectable | 1sguA-1sb3A:9.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 6 | ASP A 25ALA A 28GLY A 48GLY A 49ILE A 50PRO A 81 | None | 0.54A | 1sguA-1sivA:19.0 | 1sguA-1sivA:49.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sq1 | CHORISMATE SYNTHASE (Campylobacterjejuni) |
PF01264(Chorismate_synt) | 5 | ILE A 287GLY A 246GLY A 248ILE A 249ALA A 206 | None | 1.15A | 1sguA-1sq1A:undetectable | 1sguA-1sq1A:12.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1szp | DNA REPAIR PROTEINRAD51 (Saccharomycescerevisiae) |
PF08423(Rad51)PF14520(HHH_5) | 5 | ASP A 168ILE A 158GLY A 211GLY A 210ILE A 208 | None | 1.28A | 1sguA-1szpA:undetectable | 1sguA-1szpA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tdj | BIOSYNTHETICTHREONINE DEAMINASE (Escherichiacoli) |
PF00291(PALP)PF00585(Thr_dehydrat_C) | 5 | ALA A 211GLY A 191GLY A 190ILE A 247ALA A 214 | NonePLP A 962 (-3.1A)PLP A 962 (-3.5A)NoneNone | 1.05A | 1sguA-1tdjA:undetectable | 1sguA-1tdjA:11.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1to6 | GLYCERATE KINASE (Neisseriameningitidis) |
PF02595(Gly_kinase) | 5 | ALA A 241ILE A 224GLY A 139GLY A 140ILE A 143 | None | 1.03A | 1sguA-1to6A:undetectable | 1sguA-1to6A:14.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ton | TONIN (Rattus rattus) |
PF00089(Trypsin) | 5 | ALA A 138GLY A 43GLY A 196ILE A 212ALA A 226 | None | 1.28A | 1sguA-1tonA:undetectable | 1sguA-1tonA:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqy | ACTINORHODINPOLYKETIDE PUTATIVEBETA-KETOACYLSYNTHASE 1 (Streptomycescoelicolor) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA A 107ILE A 351GLY A 352GLY A 172ALA A 73 | None | 1.11A | 1sguA-1tqyA:undetectable | 1sguA-1tqyA:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1upf | URACILPHOSPHORIBOSYLTRANSFERASE (Toxoplasmagondii) |
no annotation | 5 | ALA D 218ILE D 229GLY D 232ILE D 52PRO D 165 | NoneURF D 999 (-4.0A)NoneNoneNone | 1.12A | 1sguA-1upfD:undetectable | 1sguA-1upfD:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v59 | DIHYDROLIPOAMIDEDEHYDROGENASE (Saccharomycescerevisiae) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 21GLY A 13GLY A 12ILE A 11ALA A 343 | NoneFAD A 480 ( 4.8A)FAD A 480 (-3.1A)NoneNone | 1.23A | 1sguA-1v59A:undetectable | 1sguA-1v59A:13.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcg | ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE (Thermusthermophilus) |
PF01070(FMN_dh) | 5 | ASP A 210ALA A 212GLY A 216GLY A 264ALA A 65 | NoneFMN A 501 ( 3.8A)FMN A 501 ( 4.0A)FMN A 501 (-4.3A)FMN A 501 (-3.3A) | 1.13A | 1sguA-1vcgA:undetectable | 1sguA-1vcgA:13.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcj | NEURAMINIDASE (Influenza Bvirus) |
PF00064(Neur) | 5 | ALA A 121GLY A 412ILE A 445PRO A 118ALA A 131 | None | 1.09A | 1sguA-1vcjA:undetectable | 1sguA-1vcjA:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcv | PROBABLEDEOXYRIBOSE-PHOSPHATE ALDOLASE (Pyrobaculumaerophilum) |
PF01791(DeoC) | 5 | ALA A 142GLY A 109ILE A 105PRO A 88ALA A 87 | None | 1.19A | 1sguA-1vcvA:undetectable | 1sguA-1vcvA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wkq | GUANINE DEAMINASE (Bacillussubtilis) |
PF00383(dCMP_cyt_deam_1) | 5 | ALA A 52ILE A 22GLY A 23GLY A 24ALA A 28 | None | 1.09A | 1sguA-1wkqA:undetectable | 1sguA-1wkqA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhk | PUTATIVE PROTEASE LAHOMOLOG (Methanocaldococcusjannaschii) |
PF05362(Lon_C) | 5 | ALA A 466ILE A 587GLY A 588GLY A 589ALA A 573 | None | 1.24A | 1sguA-1xhkA:undetectable | 1sguA-1xhkA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhk | PUTATIVE PROTEASE LAHOMOLOG (Methanocaldococcusjannaschii) |
PF05362(Lon_C) | 5 | ALA A 466ILE A 587GLY A 588GLY A 589ALA A 597 | None | 1.10A | 1sguA-1xhkA:undetectable | 1sguA-1xhkA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y89 | DEVB PROTEIN (Vibrio cholerae) |
PF01182(Glucosamine_iso) | 5 | ASP A 68ALA A 146GLY A 143GLY A 140PRO A 167 | PO4 A 239 ( 4.9A)NoneNonePO4 A 241 (-3.3A)None | 1.26A | 1sguA-1y89A:undetectable | 1sguA-1y89A:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 5 | ASP A 54ILE A 309GLY A 422GLY A 394ALA A 52 | NoneNoneIMP A 500 (-3.1A)IMP A 500 (-3.0A)None | 1.03A | 1sguA-1zfjA:undetectable | 1sguA-1zfjA:13.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zl0 | HYPOTHETICAL PROTEINPA5198 (Pseudomonasaeruginosa) |
PF02016(Peptidase_S66) | 5 | ALA A 137GLY A 134GLY A 113ILE A 117ALA A 19 | None | 1.07A | 1sguA-1zl0A:undetectable | 1sguA-1zl0A:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2anl | PLASMEPSIN IV (Plasmodiummalariae) |
PF00026(Asp) | 5 | ASP A 316ILE A 173GLY A 172GLY A 171ILE A 149 | None | 1.16A | 1sguA-2anlA:6.4 | 1sguA-2anlA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c81 | GLUTAMINE-2-DEOXY-SCYLLO-INOSOSEAMINOTRANSFERASE (Bacilluscirculans) |
PF01041(DegT_DnrJ_EryC1) | 5 | ASP A 163ALA A 165GLY A 199GLY A 200ALA A 98 | PMP A1416 (-2.8A)PMP A1416 (-3.5A)NoneNoneNone | 0.97A | 1sguA-2c81A:undetectable | 1sguA-2c81A:12.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c81 | GLUTAMINE-2-DEOXY-SCYLLO-INOSOSEAMINOTRANSFERASE (Bacilluscirculans) |
PF01041(DegT_DnrJ_EryC1) | 5 | ASP A 163ALA A 165GLY A 200ILE A 202ALA A 98 | PMP A1416 (-2.8A)PMP A1416 (-3.5A)NoneNoneNone | 1.30A | 1sguA-2c81A:undetectable | 1sguA-2c81A:12.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c81 | GLUTAMINE-2-DEOXY-SCYLLO-INOSOSEAMINOTRANSFERASE (Bacilluscirculans) |
PF01041(DegT_DnrJ_EryC1) | 5 | ASP A 163GLY A 199GLY A 200ILE A 201ALA A 73 | PMP A1416 (-2.8A)NoneNoneNoneNone | 1.18A | 1sguA-2c81A:undetectable | 1sguA-2c81A:12.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cb4 | MOSQUITOCIDAL TOXIN (Lysinibacillussphaericus) |
no annotation | 5 | ASP A 273ILE A 139GLY A 202GLY A 203ILE A 204 | None | 1.30A | 1sguA-2cb4A:undetectable | 1sguA-2cb4A:15.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cy8 | D-PHENYLGLYCINEAMINOTRANSFERASE (Pseudomonasstutzeri) |
PF00202(Aminotran_3) | 5 | ASP A 241GLY A 120GLY A 278ILE A 279ALA A 129 | None | 1.27A | 1sguA-2cy8A:undetectable | 1sguA-2cy8A:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cy8 | D-PHENYLGLYCINEAMINOTRANSFERASE (Pseudomonasstutzeri) |
PF00202(Aminotran_3) | 5 | ASP A 241GLY A 277GLY A 278ILE A 279ALA A 129 | None | 1.12A | 1sguA-2cy8A:undetectable | 1sguA-2cy8A:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1q | LUCIFERIN4-MONOOXYGENASE (Luciolacruciata) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ALA A 68ILE A 100GLY A 97ILE A 92ALA A 180 | CSO A 64 ( 3.4A)NoneNoneNoneCSO A 64 ( 3.8A) | 1.09A | 1sguA-2d1qA:undetectable | 1sguA-2d1qA:10.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3t | FATTY OXIDATIONCOMPLEX ALPHASUBUNIT (Pseudomonasfragi) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | ALA A 69ILE A 66GLY A 118GLY A 116ALA A 92 | None | 1.29A | 1sguA-2d3tA:undetectable | 1sguA-2d3tA:8.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dfa | HYPOTHETICAL UPF0271PROTEIN TTHB195 (Thermusthermophilus) |
PF03746(LamB_YcsF) | 5 | ASP A 21GLY A 39GLY A 40ILE A 45ALA A 31 | None | 1.13A | 1sguA-2dfaA:undetectable | 1sguA-2dfaA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2egu | CYSTEINE SYNTHASE (Geobacilluskaustophilus) |
PF00291(PALP) | 5 | ALA A 251GLY A 264GLY A 263ILE A 261ALA A 274 | None | 1.21A | 1sguA-2eguA:undetectable | 1sguA-2eguA:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f4e | ATFKBP42 (Arabidopsisthaliana) |
PF00254(FKBP_C) | 5 | ALA A 122GLY A 59GLY A 119PRO A 64ALA A 114 | None | 1.25A | 1sguA-2f4eA:undetectable | 1sguA-2f4eA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f5x | BUGD (Bordetellapertussis) |
PF03401(TctC) | 5 | ALA A 138GLY A 48GLY A 47ILE A 135ALA A 131 | ASP A 901 (-3.5A)NoneNoneNoneNone | 1.10A | 1sguA-2f5xA:undetectable | 1sguA-2f5xA:15.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fbm | Y CHROMOSOMECHROMODOMAIN PROTEIN1, TELOMERIC ISOFORMB (Homo sapiens) |
PF00378(ECH_1) | 5 | ALA A 308ILE A 392GLY A 393GLY A 395ILE A 398 | None | 1.27A | 1sguA-2fbmA:undetectable | 1sguA-2fbmA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fbm | Y CHROMOSOMECHROMODOMAIN PROTEIN1, TELOMERIC ISOFORMB (Homo sapiens) |
PF00378(ECH_1) | 5 | ALA A 308ILE A 392GLY A 393ILE A 398ALA A 336 | None | 1.25A | 1sguA-2fbmA:undetectable | 1sguA-2fbmA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fja | ADENYLYLSULFATEREDUCTASE, SUBUNIT A (Archaeoglobusfulgidus) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | ALA A 37GLY A 30GLY A 29ILE A 28ALA A 441 | NoneFAD A1000 (-4.3A)FAD A1000 (-3.3A)NoneNone | 0.98A | 1sguA-2fjaA:undetectable | 1sguA-2fjaA:9.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fja | ADENYLYLSULFATEREDUCTASE, SUBUNIT A (Archaeoglobusfulgidus) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | ALA A 38GLY A 30GLY A 29ILE A 28ALA A 459 | NoneFAD A1000 (-4.3A)FAD A1000 (-3.3A)NoneNone | 1.31A | 1sguA-2fjaA:undetectable | 1sguA-2fjaA:9.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ILE A 53GLY A 54GLY A 55PRO A 86 | LP1 A 201 (-2.3A)LP1 A 201 (-3.5A)LP1 A 201 (-4.6A)LP1 A 201 (-3.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A) | 0.38A | 1sguA-2fmbA:15.2 | 1sguA-2fmbA:27.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fw2 | TESTIS-SPECIFICCHROMODOMAIN PROTEINY 2 (Homo sapiens) |
PF00378(ECH_1) | 5 | ALA A 28ILE A 112GLY A 113GLY A 115ILE A 118 | None | 1.22A | 1sguA-2fw2A:undetectable | 1sguA-2fw2A:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fw2 | TESTIS-SPECIFICCHROMODOMAIN PROTEINY 2 (Homo sapiens) |
PF00378(ECH_1) | 5 | ALA A 28ILE A 112GLY A 113ILE A 118ALA A 56 | None | 1.23A | 1sguA-2fw2A:undetectable | 1sguA-2fw2A:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g3n | ALPHA-GLUCOSIDASE (Sulfolobussolfataricus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 5 | ILE A 102GLY A 68GLY A 66ILE A 65PRO A 528 | None | 1.18A | 1sguA-2g3nA:undetectable | 1sguA-2g3nA:9.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gqd | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Staphylococcusaureus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ILE A 106GLY A 190GLY A 237ILE A 349ALA A 194 | None | 1.30A | 1sguA-2gqdA:undetectable | 1sguA-2gqdA:14.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h1t | HYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF06475(Glycolipid_bind) | 5 | ASP A 151ALA A 152ILE A 115GLY A 175ILE A 178 | None | 1.32A | 1sguA-2h1tA:undetectable | 1sguA-2h1tA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hdw | HYPOTHETICAL PROTEINPA2218 (Pseudomonasaeruginosa) |
PF02129(Peptidase_S15) | 5 | ALA A 188GLY A 182GLY A 177ILE A 176ALA A 158 | None | 1.23A | 1sguA-2hdwA:undetectable | 1sguA-2hdwA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hfs | MEVALONATE KINASE,PUTATIVE (Leishmaniamajor) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | ILE A 165GLY A 163GLY A 37ILE A 38ALA A 113 | None | 1.30A | 1sguA-2hfsA:undetectable | 1sguA-2hfsA:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i14 | NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE (Pyrococcusfuriosus) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 5 | ALA A 295GLY A 289GLY A 135ILE A 136ALA A 150 | NonePCP A 392 (-3.3A)NoneNoneNone | 1.32A | 1sguA-2i14A:undetectable | 1sguA-2i14A:13.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2idc | ANTI-SILENCINGPROTEIN 1 ANDHISTONE H3 CHIMERA (Saccharomycescerevisiae) |
PF04729(ASF1_hist_chap) | 5 | ASP A 20ALA A 16ILE A 139ILE A 135PRO A 79 | None | 1.20A | 1sguA-2idcA:undetectable | 1sguA-2idcA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2if4 | ATFKBP42 (Arabidopsisthaliana) |
PF00254(FKBP_C)PF13181(TPR_8) | 5 | ALA A 122GLY A 59GLY A 119PRO A 64ALA A 114 | None | 1.22A | 1sguA-2if4A:undetectable | 1sguA-2if4A:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2irm | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 7INTERACTING PROTEIN1 (Anophelesgambiae) |
PF00481(PP2C) | 5 | ALA A 169ILE A 271GLY A 270GLY A 269ILE A 267 | None | 1.13A | 1sguA-2irmA:undetectable | 1sguA-2irmA:12.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4r | EXOPOLYPHOSPHATASE (Aquifexaeolicus) |
PF02541(Ppx-GppA) | 5 | ASP A 141ILE A 165GLY A 166GLY A 145PRO A 116 | None | 1.27A | 1sguA-2j4rA:undetectable | 1sguA-2j4rA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j7v | TLL2115 PROTEIN (Synechococcuselongatus) |
PF13354(Beta-lactamase2) | 5 | ALA A 244GLY A 52GLY A 37PRO A 58ALA A 59 | None | 1.24A | 1sguA-2j7vA:undetectable | 1sguA-2j7vA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jir | PERIPLASMIC NITRATEREDUCTASE (Desulfovibriodesulfuricans) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 5 | ILE A 123GLY A 127GLY A 126ILE A 389ALA A 358 | None | 1.29A | 1sguA-2jirA:undetectable | 1sguA-2jirA:11.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lxn | GMP SYNTHASE[GLUTAMINE-HYDROLYZING] SUBUNIT A (Methanocaldococcusjannaschii) |
PF00117(GATase) | 5 | ASP A 106ALA A 140ILE A 175GLY A 172PRO A 116 | None | 1.25A | 1sguA-2lxnA:undetectable | 1sguA-2lxnA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oga | TRANSAMINASE (Streptomycesvenezuelae) |
PF01041(DegT_DnrJ_EryC1) | 5 | ASP A 164ALA A 166GLY A 201GLY A 202ALA A 99 | PGU A1020 (-2.6A)PGU A1020 (-3.5A)NoneNoneNone | 1.00A | 1sguA-2ogaA:undetectable | 1sguA-2ogaA:11.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oqc | PENICILLIN V ACYLASE (Bacillussubtilis) |
PF02275(CBAH) | 5 | ALA A 53ILE A 71GLY A 70GLY A 56ILE A 30 | None | 0.96A | 1sguA-2oqcA:undetectable | 1sguA-2oqcA:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oz4 | FAB FRAGMENT, HEAVYCHAININTERCELLULARADHESION MOLECULE 1 (Homo sapiens;Mus musculus) |
PF07654(C1-set)PF07686(V-set)no annotation | 5 | ASP A 375ILE A 414GLY A 415GLY H 57ILE H 51 | None | 1.25A | 1sguA-2oz4A:undetectable | 1sguA-2oz4A:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2po3 | 4-DEHYDRASE (Streptomycesvenezuelae) |
PF01041(DegT_DnrJ_EryC1) | 5 | ASP A1171ALA A1173GLY A1207GLY A1208ALA A1106 | T4K A1500 ( 2.7A)T4K A1500 ( 3.4A)NoneNoneNone | 0.98A | 1sguA-2po3A:undetectable | 1sguA-2po3A:12.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q2e | TYPE 2 DNATOPOISOMERASE 6SUBUNIT B (Methanosarcinamazei) |
PF02518(HATPase_c)PF09239(Topo-VIb_trans) | 5 | ALA B 424ILE B 320GLY B 321PRO B 230ALA B 231 | None | 1.19A | 1sguA-2q2eB:undetectable | 1sguA-2q2eB:9.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qi9 | VITAMIN B12 IMPORTSYSTEM PERMEASEPROTEIN BTUC (Escherichiacoli) |
PF01032(FecCD) | 5 | ALA A 148ILE A 128GLY A 92GLY A 153ILE A 154 | None | 1.05A | 1sguA-2qi9A:undetectable | 1sguA-2qi9A:18.64 |