SIMILAR PATTERNS OF AMINO ACIDS FOR 1SG9_C_SAMC303

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		5 PRO A 346
ILE A 310
GLY A 313
VAL A 266
SER A 267
 None
 1.09A 1sg9C-1dabA:
undetectable		 1sg9C-1dabA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A  74
ALA A  72
VAL A 195
GLU A 147
ALA A 168
 None
 1.07A 1sg9C-1fnoA:
undetectable		 1sg9C-1fnoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ILE A 180
GLY A 586
VAL A  22
SER A  21
ASN A 177
 None
None
SF4  A1010 ( 4.3A)
None
None
 1.09A 1sg9C-1h0hA:
undetectable		 1sg9C-1h0hA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0r CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF01613
(Flavin_Reduct) 		5 ILE A  42
GLY A  63
ALA A  61
VAL A  66
SER A  65
 None
 1.07A 1sg9C-1i0rA:
undetectable		 1sg9C-1i0rA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy8 LEVODIONE REDUCTASE

(Leifsonia
aquatica) 		PF13561
(adh_short_C2) 		5 GLY A  22
ALA A  30
VAL A  45
SER A  46
ASN A  99
 NAD  A1268 ( 4.1A)
None
NAD  A1268 (-3.9A)
None
NAD  A1268 (-3.3A)
 1.16A 1sg9C-1iy8A:
7.1		 1sg9C-1iy8A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		5 ILE A  44
GLY A  47
ALA A  50
ASN A 113
PRO A 115
 None
 0.76A 1sg9C-1qyrA:
11.7		 1sg9C-1qyrA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense) 		PF09492
(Pec_lyase) 		5 PRO A 311
ILE A 232
ALA A 313
PHE A 213
ALA A  33
 None
 1.16A 1sg9C-1r76A:
undetectable		 1sg9C-1r76A:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		12 PHE A 100
PRO A 102
ILE A 128
GLY A 131
ALA A 134
VAL A 152
SER A 153
GLU A 179
PHE A 180
ASN A 197
PRO A 199
ALA A 218
 SAM  A 301 ( 3.4A)
SAM  A 301 (-3.6A)
None
SAM  A 301 ( 3.8A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.3A)
None
None
SAM  A 301 (-3.5A)
GLN  A 400 ( 3.1A)
SAM  A 301 ( 4.6A)
SAM  A 301 (-3.3A)
 0.15A 1sg9C-1sg9A:
43.7		 1sg9C-1sg9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)

(Archaeoglobus
fulgidus) 		PF01888
(CbiD) 		5 ILE A  56
ALA A  48
VAL A  63
GLU A  61
ASN A 142
 None
 1.09A 1sg9C-1sr8A:
undetectable		 1sg9C-1sr8A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		5 PRO A  65
ILE A 133
GLY A  72
ALA A  68
ALA A  35
 None
 1.17A 1sg9C-1tf1A:
undetectable		 1sg9C-1tf1A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9w PUTATIVE 42-9-9
PROTEIN

(Mus musculus) 		PF06110
(DUF953) 		5 PRO A 101
ALA A  56
VAL A  14
GLU A  12
ALA A  36
 None
 1.11A 1sg9C-1v9wA:
undetectable		 1sg9C-1v9wA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9w PUTATIVE 42-9-9
PROTEIN

(Mus musculus) 		PF06110
(DUF953) 		5 PRO A 101
ALA A  56
VAL A  14
SER A  15
GLU A  12
 None
 1.11A 1sg9C-1v9wA:
undetectable		 1sg9C-1v9wA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01207
(Dus) 		5 PRO A  70
GLY A  67
VAL A  37
SER A  38
ALA A  76
 SO4  A 320 (-4.1A)
None
None
None
None
 1.13A 1sg9C-1vhnA:
2.0		 1sg9C-1vhnA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x60 SPORULATION-SPECIFIC
N-ACETYLMURAMOYL-L-A
LANINE AMIDASE

(Bacillus
subtilis) 		PF05036
(SPOR) 		5 PHE A  35
ILE A  74
GLY A  51
VAL A  48
ALA A  30
 None
 1.15A 1sg9C-1x60A:
undetectable		 1sg9C-1x60A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		5 PHE A 467
GLY A 521
ALA A 526
VAL A 385
ALA A 396
 None
 1.09A 1sg9C-1yvpA:
2.4		 1sg9C-1yvpA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 PHE A 285
ALA A 253
GLU A  72
ASN A  41
PRO A  35
 None
 1.14A 1sg9C-2abqA:
2.7		 1sg9C-2abqA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		6 PRO A  91
GLY A 119
ALA A 122
ASN A 183
PRO A 185
ALA A 206
 SAH  A 300 (-4.0A)
SAH  A 300 (-3.5A)
SAH  A 300 (-3.4A)
SAH  A 300 (-3.9A)
SAH  A 300 ( 3.9A)
SAH  A 300 (-3.4A)
 0.50A 1sg9C-2b3tA:
28.9		 1sg9C-2b3tA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4w HYPOTHETICAL
PROTEIN, CONSERVED

(Leishmania
major) 		PF08950
(DUF1861) 		5 PHE A 265
ILE A  45
GLY A 282
VAL A  30
PRO A  84
 None
 1.15A 1sg9C-2b4wA:
undetectable		 1sg9C-2b4wA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bm3 SCAFFOLDING DOCKERIN
BINDING PROTEIN A

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		5 GLY A  91
VAL A 132
PHE A 134
ASN A  86
ALA A  52
 None
 1.11A 1sg9C-2bm3A:
undetectable		 1sg9C-2bm3A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ek8 AMINOPEPTIDASE

(Aneurinibacillus
sp. AM-1) 		PF02225
(PA)
PF04389
(Peptidase_M28) 		5 ILE A 207
GLY A 270
VAL A  41
GLU A  45
PRO A  59
 None
 1.17A 1sg9C-2ek8A:
undetectable		 1sg9C-2ek8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fli RIBULOSE-PHOSPHATE
3-EPIMERASE

(Streptococcus
pyogenes) 		PF00834
(Ribul_P_3_epim) 		5 ILE A  25
VAL A 208
SER A 209
GLU A  27
ALA A 204
 None
 1.17A 1sg9C-2fliA:
undetectable		 1sg9C-2fliA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		5 ILE A1681
ALA A1843
VAL A1837
PHE A1750
ALA A1872
 None
 0.92A 1sg9C-2fr1A:
5.8		 1sg9C-2fr1A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN

(Homo sapiens) 		PF05971
(Methyltransf_10) 		6 PRO A  40
ILE A  72
GLY A  75
VAL A  97
ASN A 147
PRO A 149
 SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.6A)
SAH  A 300 (-4.2A)
SAH  A 300 (-3.9A)
SAH  A 300 (-4.0A)
 0.55A 1sg9C-2h00A:
17.5		 1sg9C-2h00A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		5 ILE A 529
GLY A 507
ALA A 524
PRO A 503
ALA A 504
 None
 1.07A 1sg9C-2oajA:
undetectable		 1sg9C-2oajA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A  22
ALA A  99
VAL A 388
SER A 389
ALA A  57
 None
 1.17A 1sg9C-2ox4A:
undetectable		 1sg9C-2ox4A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ILE A 389
GLY A 323
ALA A 326
VAL A 360
SER A 359
 None
 1.13A 1sg9C-2p0uA:
undetectable		 1sg9C-2p0uA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		5 ILE A 103
GLY A 296
ALA A 301
VAL A 112
SER A 113
 None
 1.10A 1sg9C-2pgeA:
undetectable		 1sg9C-2pgeA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		no annotation 5 ILE 1 195
GLY 1 155
ALA 1 153
VAL 1 158
SER 1 157
 None
 1.10A 1sg9C-2ws91:
undetectable		 1sg9C-2ws91:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x30 PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
coelicolor) 		PF00977
(His_biosynth) 		5 ILE A 168
GLY A 197
ALA A 195
GLU A  24
ASN A 178
 None
SO4  A1242 (-3.4A)
None
None
None
 1.16A 1sg9C-2x30A:
undetectable		 1sg9C-2x30A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvn ASPERGILLUS
FUMIGATUS CHITINASE
A1

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		5 PRO A 274
ALA A 279
ASN A 320
PRO A 326
ALA A 328
 None
 1.13A 1sg9C-2xvnA:
undetectable		 1sg9C-2xvnA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		5 PHE A 207
GLY A 243
ALA A 246
ASN A 305
PRO A 307
 SAH  A 376 (-3.4A)
SAH  A 376 (-3.4A)
SAH  A 376 (-3.3A)
SAH  A 376 (-4.4A)
SAH  A 376 ( 4.3A)
 0.60A 1sg9C-2zwvA:
18.0		 1sg9C-2zwvA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Huperzia
serrata) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ILE A 381
GLY A 315
ALA A 318
VAL A 352
SER A 351
 None
GOL  A 500 ( 3.9A)
None
None
None
 1.17A 1sg9C-3awkA:
undetectable		 1sg9C-3awkA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7o ENDO-1,4-BETA-XYLANA
SE

(Bacillus
subtilis) 		PF03422
(CBM_6)
PF04616
(Glyco_hydro_43) 		5 PHE A 283
ILE A  17
SER A 310
ASN A  14
ALA A 306
 None
 1.03A 1sg9C-3c7oA:
undetectable		 1sg9C-3c7oA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		5 ILE A 422
ALA A 294
VAL A 435
PRO A 419
ALA A 372
 None
 1.18A 1sg9C-3clqA:
undetectable		 1sg9C-3clqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		5 ILE A  10
VAL A 234
SER A 232
PRO A 254
ALA A 252
 None
 1.11A 1sg9C-3d43A:
undetectable		 1sg9C-3d43A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 3

(Schizosaccharomyces
pombe) 		PF00022
(Actin) 		5 PHE A 388
GLY A 390
ALA A  22
VAL A 162
ALA A 167
 None
 1.10A 1sg9C-3dwlA:
undetectable		 1sg9C-3dwlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecy CG4584-PA, ISOFORM A
(BCDNA.LD08534)

(Drosophila
melanogaster) 		PF00692
(dUTPase) 		5 ILE A  90
GLY A  93
VAL A  62
PHE A 117
ALA A 126
 None
 1.05A 1sg9C-3ecyA:
undetectable		 1sg9C-3ecyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF00480
(ROK) 		5 PRO A 704
GLY A 708
ALA A 521
VAL A 713
ALA A 411
 UNX  A   2 ( 3.9A)
None
None
None
None
 1.13A 1sg9C-3eo3A:
undetectable		 1sg9C-3eo3A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF07992
(Pyr_redox_2) 		5 ILE A   6
GLY A  10
ALA A  13
VAL A  75
ALA A  33
 None
None
FAD  A 298 (-3.5A)
None
FAD  A 298 (-3.5A)
 1.09A 1sg9C-3fbsA:
3.6		 1sg9C-3fbsA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdo UNCHARACTERIZED
OXIDOREDUCTASE YVAA

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A  74
GLY A  97
VAL A 100
ASN A  70
ALA A  92
 None
 1.12A 1sg9C-3gdoA:
4.0		 1sg9C-3gdoA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Candida
albicans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		6 PHE A  75
PRO A  71
ILE A 365
ALA A 100
VAL A 105
SER A 106
 None
 1.39A 1sg9C-3hskA:
3.6		 1sg9C-3hskA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icl EAL/GGDEF DOMAIN
PROTEIN

(Methylococcus
capsulatus) 		PF00990
(GGDEF) 		5 PHE A  34
GLY A 123
ALA A 125
VAL A 120
SER A 121
 None
 1.16A 1sg9C-3iclA:
undetectable		 1sg9C-3iclA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 PRO A1203
GLY A 871
ALA A 448
PRO A 867
ALA A 865
 None
 1.16A 1sg9C-3ikmA:
undetectable		 1sg9C-3ikmA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1

(Ehrlichia
chaffeensis) 		PF13419
(HAD_2) 		5 PRO A 155
ILE A 180
ALA A 175
PRO A   4
ALA A   6
 None
 1.11A 1sg9C-3kzxA:
2.6		 1sg9C-3kzxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE

(Sus scrofa) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 PHE A 194
GLY A 244
ALA A 248
PRO A 189
ALA A 193
 None
 0.98A 1sg9C-3mdeA:
undetectable		 1sg9C-3mdeA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2) 		5 PRO A 400
ALA A 333
VAL A 259
GLU A 246
PHE A 244
 None
 1.01A 1sg9C-3nvqA:
undetectable		 1sg9C-3nvqA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Rubrobacter
xylanophilus) 		PF00535
(Glycos_transf_2) 		5 PRO A  49
GLY A 116
VAL A 323
GLU A 321
ALA A 112
 GDD  A 340 (-4.8A)
None
None
None
None
 1.03A 1sg9C-3o3pA:
undetectable		 1sg9C-3o3pA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pic CIP2

(Trichoderma
reesei) 		no annotation 5 PRO A 348
ILE A 452
ALA A 109
SER A 380
ASN A 112
 None
 1.13A 1sg9C-3picA:
undetectable		 1sg9C-3picA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		5 ILE A  39
GLY A  42
ALA A  45
ASN A 106
PRO A 108
 None
 0.97A 1sg9C-3tqsA:
11.5		 1sg9C-3tqsA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE

(Leptospirillum
rubarum) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 ILE A  41
GLY A 237
SER A 233
PHE A  59
ASN A  36
 None
 1.16A 1sg9C-3ttgA:
undetectable		 1sg9C-3ttgA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		5 PRO A  69
ILE A 270
GLY A 277
VAL A 280
ALA A 320
 None
 1.13A 1sg9C-3ucqA:
4.4		 1sg9C-3ucqA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		5 ILE A  45
GLY A  48
ALA A  51
ASN A 117
PRO A 119
 None
 0.93A 1sg9C-3uzuA:
10.8		 1sg9C-3uzuA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v76 FLAVOPROTEIN

(Sinorhizobium
meliloti) 		PF03486
(HI0933_like) 		5 ILE A  11
GLY A 162
ALA A 171
VAL A 366
ALA A  15
 None
FDA  A 547 (-3.4A)
None
None
FDA  A 547 (-3.9A)
 1.09A 1sg9C-3v76A:
3.5		 1sg9C-3v76A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn3 ANTIFREEZE PROTEIN

(Typhula
ishikariensis) 		PF11999
(DUF3494) 		5 ILE A 158
GLY A 112
SER A 129
PHE A 185
ALA A 109
 None
None
None
None
EDO  A 304 (-3.5A)
 1.08A 1sg9C-3vn3A:
undetectable		 1sg9C-3vn3A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxi DYP

(Bjerkandera
adusta) 		PF04261
(Dyp_perox) 		5 PRO A 314
ILE A 386
VAL A 402
PRO A 304
ALA A 307
 None
 1.17A 1sg9C-3vxiA:
undetectable		 1sg9C-3vxiA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvk TOXIN OF
TOXIN-ANTITOXIN
SYSTEM

(Rickettsia
felis) 		PF01850
(PIN) 		5 ILE A  34
GLY A   6
SER A  37
GLU A  69
ALA A 106
 None
 1.01A 1sg9C-3zvkA:
undetectable		 1sg9C-3zvkA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 PRO A 219
GLY A  86
ALA A  88
PRO A  64
ALA A 226
 None
 1.04A 1sg9C-3zyvA:
undetectable		 1sg9C-3zyvA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		5 PRO A  65
ILE A 262
GLY A 269
VAL A 272
ALA A 312
 None
 1.06A 1sg9C-4aysA:
undetectable		 1sg9C-4aysA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b1l LEVANASE

(Bacillus
subtilis) 		PF06439
(DUF1080) 		5 PHE A 548
GLY A 660
ALA A 576
GLU A 656
ALA A 585
 None
 1.16A 1sg9C-4b1lA:
undetectable		 1sg9C-4b1lA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvl PHB DEPOLYMERASE
PHAZ7

(Paucimonas
lemoignei) 		PF01674
(Lipase_2) 		5 ILE A 316
GLY A 337
ALA A 276
GLU A 333
ASN A 312
 None
 1.06A 1sg9C-4bvlA:
undetectable		 1sg9C-4bvlA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
PF17243
(POTRA_TamA_1) 		5 PRO A 464
ILE A 484
GLY A 495
VAL A 526
SER A 527
 None
 0.95A 1sg9C-4c00A:
undetectable		 1sg9C-4c00A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		5 ILE A 528
ALA A 333
VAL A 360
PHE A 501
ALA A 523
 None
 1.04A 1sg9C-4c22A:
undetectable		 1sg9C-4c22A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE A 421
GLY A 413
ALA A 379
SER A 124
ALA A 444
 None
 1.17A 1sg9C-4c7vA:
3.0		 1sg9C-4c7vA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		5 PHE A 208
GLY A 238
SER A 261
ASN A 305
PRO A 307
 SAM  A 401 (-3.6A)
SAM  A 401 ( 3.7A)
None
SAM  A 401 (-3.8A)
SAM  A 401 (-4.0A)
 0.37A 1sg9C-4dcmA:
17.2		 1sg9C-4dcmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		5 PRO A 103
GLY A  85
ALA A  81
SER A  55
ALA A  10
 None
 0.86A 1sg9C-4e3aA:
3.3		 1sg9C-4e3aA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		5 ILE A  59
GLY A  12
ALA A  90
VAL A  46
ALA A  41
 None
 1.12A 1sg9C-4e3zA:
6.4		 1sg9C-4e3zA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ILE A 276
GLY A 254
ALA A 288
SER A 252
ALA A 228
 None
None
None
MOA  A 702 (-2.8A)
None
 1.06A 1sg9C-4fxsA:
undetectable		 1sg9C-4fxsA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvl MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
thermoresistibile) 		PF00082
(Peptidase_S8) 		5 PRO A  35
GLY A 219
ALA A 185
VAL A  28
GLU A  25
 None
None
None
None
ZN  A 507 (-2.1A)
 1.03A 1sg9C-4hvlA:
undetectable		 1sg9C-4hvlA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		5 ILE A 276
GLY A 254
ALA A 288
SER A 252
ALA A 228
 None
 1.12A 1sg9C-4ix2A:
undetectable		 1sg9C-4ix2A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Archaeoglobus
fulgidus) 		PF00215
(OMPdecase) 		5 ILE A  80
GLY A 106
SER A 110
GLU A 115
ALA A 153
 None
 1.04A 1sg9C-4muzA:
undetectable		 1sg9C-4muzA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		5 PRO A 464
ILE A 484
GLY A 495
VAL A 526
SER A 527
 None
 0.93A 1sg9C-4n74A:
undetectable		 1sg9C-4n74A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 PHE A 194
GLY A 244
ALA A 248
PRO A 189
ALA A 193
 None
 1.07A 1sg9C-4p13A:
undetectable		 1sg9C-4p13A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		5 ILE A 218
GLY A 210
VAL A 226
GLU A 225
ASN A 213
 None
 1.07A 1sg9C-4p47A:
undetectable		 1sg9C-4p47A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		5 GLY B 194
ALA B 171
SER A 147
PRO B 197
ALA B 142
 None
 1.15A 1sg9C-4pelB:
2.2		 1sg9C-4pelB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv5 LACTOYLGLUTATHIONE
LYASE

(Mus musculus) 		PF00903
(Glyoxalase) 		5 PRO A 177
ILE A 164
ALA A 131
SER A 137
GLU A 143
 None
 1.12A 1sg9C-4pv5A:
undetectable		 1sg9C-4pv5A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN

(Clostridium
perfringens) 		PF12849
(PBP_like_2) 		5 GLY A  56
ALA A  58
VAL A   6
SER A   7
PHE A  25
 None
 1.16A 1sg9C-4q8rA:
undetectable		 1sg9C-4q8rA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF13407
(Peripla_BP_4) 		5 GLY A 217
ALA A 165
VAL A 240
GLU A 142
ASN A 132
 None
 1.17A 1sg9C-4ry0A:
5.0		 1sg9C-4ry0A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 ILE A 110
GLY A 261
ALA A 268
GLU A 334
ALA A 284
 None
 1.14A 1sg9C-4w1wA:
undetectable		 1sg9C-4w1wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wct FRUCTOSYL
AMINE:OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		5 ILE A 380
GLY A 368
PHE A 383
ASN A 372
ALA A 351
 None
 1.15A 1sg9C-4wctA:
2.1		 1sg9C-4wctA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xll DJ-1 FAMILY PROTEIN

(Toxoplasma
gondii) 		PF01965
(DJ-1_PfpI) 		5 ALA A  88
VAL A  33
GLU A  31
ASN A  62
ALA A  59
 None
 1.07A 1sg9C-4xllA:
3.6		 1sg9C-4xllA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9d C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		5 ILE A  60
GLY A  14
ALA A  92
VAL A  47
ALA A  42
 None
None
NAI  A 401 (-3.6A)
None
None
 1.01A 1sg9C-4y9dA:
7.3		 1sg9C-4y9dA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9d C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		5 PHE A  20
ILE A  60
GLY A  14
SER A  89
ALA A  23
 None
 1.14A 1sg9C-4y9dA:
7.3		 1sg9C-4y9dA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 PRO A 173
ILE A  48
ALA A 129
SER A 162
GLU A 154
 None
 1.11A 1sg9C-4zktA:
undetectable		 1sg9C-4zktA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		5 PHE A 544
PRO A 615
ILE A 608
GLY A 545
ALA A 731
 None
 1.05A 1sg9C-5a42A:
undetectable		 1sg9C-5a42A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 PRO A 219
GLY A  83
ALA A  85
PRO A  61
ALA A 226
 None
 0.98A 1sg9C-5epgA:
2.0		 1sg9C-5epgA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewt EXODEOXYRIBONUCLEASE
III XTH

(Sulfolobus
islandicus) 		PF03372
(Exo_endo_phos) 		5 ILE A  31
GLY A 143
ALA A 105
PHE A  28
PRO A 241
 None
 1.15A 1sg9C-5ewtA:
2.4		 1sg9C-5ewtA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ILE A 259
GLY A 252
ALA A 202
VAL A  72
ALA A 158
 None
 1.05A 1sg9C-5fbzA:
undetectable		 1sg9C-5fbzA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 LIGHT CHAIN
(ANTI-TLR3)
HEAVY CHAIN
(ANTI-TLR3)

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		5 ALA D  35
VAL C  97
SER C  89
ASN D  62
PRO C  93
 None
 1.08A 1sg9C-5gs0D:
undetectable		 1sg9C-5gs0D:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER

(Methanocaldococcus
jannaschii) 		PF01699
(Na_Ca_ex) 		5 ILE A  30
ALA A 220
VAL A  36
SER A  37
ALA A  43
 MYS  A 405 ( 4.8A)
None
None
None
None
 1.16A 1sg9C-5hxsA:
undetectable		 1sg9C-5hxsA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PHE A  98
PRO A  56
ILE A 397
GLY A 355
PHE A 163
 FAD  A 702 (-3.8A)
None
None
None
None
 1.17A 1sg9C-5i68A:
undetectable		 1sg9C-5i68A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j98 VP2
VP3

(Slow bee
paralysis
virus;
Slow bee
paralysis virus) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 GLY B 131
PHE B 128
ASN C 137
PRO C 139
ALA B 168
 None
 1.18A 1sg9C-5j98B:
undetectable		 1sg9C-5j98B:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp7 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
subtilis) 		no annotation 5 ILE H 235
GLY H 161
ALA H 165
PRO H 248
ALA H 319
 None
 1.08A 1sg9C-5lp7H:
undetectable		 1sg9C-5lp7H:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		5 ILE A 727
GLY A 717
ALA A 772
VAL A 660
SER A 661
 None
 1.14A 1sg9C-5te1A:
4.6		 1sg9C-5te1A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tet ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE B 727
GLY B 717
ALA B 772
VAL B 660
SER B 661
 None
 1.12A 1sg9C-5tetB:
4.9		 1sg9C-5tetB:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(environmental
samples) 		PF00202
(Aminotran_3) 		5 PHE A 149
GLY A 150
ALA A 170
VAL A 114
SER A 113
 None
None
None
None
LLP  A 274 ( 2.7A)
 1.12A 1sg9C-5uc7A:
2.7		 1sg9C-5uc7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 PRO A 884
GLY A 886
ALA A1058
SER A 892
GLU A 817
 None
None
None
None
NAD  A2002 (-3.2A)
 1.13A 1sg9C-5ux5A:
3.2		 1sg9C-5ux5A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7o NOSK

(Streptomyces
actuosus) 		PF12697
(Abhydrolase_6) 		5 GLY A 237
ALA A 232
PHE A 251
ASN A 203
ALA A 101
 None
 1.17A 1sg9C-5v7oA:
undetectable		 1sg9C-5v7oA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wue UNCHARACTERIZED
PROTEIN

(Sulfolobus
acidocaldarius) 		PF03458
(UPF0126) 		5 PHE A  12
ILE A 186
GLY A 104
ALA A 100
SER A 109
 None
 1.12A 1sg9C-5wueA:
2.7		 1sg9C-5wueA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE

(Homo sapiens) 		no annotation 5 PRO A  77
ILE A 109
GLY A 112
VAL A 134
ASN A 184
 SAH  A 305 ( 4.8A)
None
SAH  A 305 (-3.4A)
SAH  A 305 (-4.1A)
SAH  A 305 (-3.4A)
 0.76A 1sg9C-6b92A:
16.5		 1sg9C-6b92A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj7 SERPIN-12

(Manduca sexta) 		no annotation 5 ILE A  33
ALA A 306
VAL A 159
PRO A  28
ALA A  26
 None
 1.13A 1sg9C-6cj7A:
undetectable		 1sg9C-6cj7A:
undetectable