SIMILAR PATTERNS OF AMINO ACIDS FOR 1SG9_B_SAMB302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpy PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		3 ASP A  94
PHE A  89
ASN A  64
 None
 0.88A 1sg9B-1dpyA:
undetectable		 1sg9B-1dpyA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 ASP C 320
PHE C 191
ASN C 187
 None
 0.80A 1sg9B-1ea9C:
undetectable		 1sg9B-1ea9C:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 3 ASP B1252
PHE B 451
ASN B1237
 None
 0.76A 1sg9B-1ej6B:
2.0		 1sg9B-1ej6B:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		3 ASP A 250
PHE A 117
ASN A 167
 None
 0.65A 1sg9B-1h7wA:
3.8		 1sg9B-1h7wA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH

(Thermus
thermophilus) 		PF00004
(AAA) 		3 ASP A 287
PHE A 241
ASN A 280
 None
 0.68A 1sg9B-1iy1A:
undetectable		 1sg9B-1iy1A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH

(Thermus
thermophilus) 		PF00004
(AAA) 		3 ASP A 287
PHE A 241
ASN A 280
 None
 0.61A 1sg9B-1iy2A:
undetectable		 1sg9B-1iy2A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv7 FTSH

(Escherichia
coli) 		PF00004
(AAA) 		3 ASP A 286
PHE A 240
ASN A 279
 None
 0.73A 1sg9B-1lv7A:
3.1		 1sg9B-1lv7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyq THREONYL-TRNA
SYNTHETASE 1

(Staphylococcus
aureus) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		3 ASP A 452
PHE A 399
ASN A 445
 None
 0.68A 1sg9B-1nyqA:
undetectable		 1sg9B-1nyqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE

(Salmonella
enterica) 		PF00583
(Acetyltransf_1) 		3 ASP A 115
PHE A 132
ASN A 120
 None
None
COA  A 600 ( 3.2A)
 0.88A 1sg9B-1s5kA:
undetectable		 1sg9B-1s5kA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		3 ASP A 151
PHE A 180
ASN A 197
 SAM  A 301 (-2.9A)
SAM  A 301 (-3.5A)
GLN  A 400 ( 3.1A)
 0.10A 1sg9B-1sg9A:
43.8		 1sg9B-1sg9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te7 HYPOTHETICAL UPF0267
PROTEIN YQFB

(Escherichia
coli) 		PF04266
(ASCH) 		3 ASP A  15
PHE A   9
ASN A  75
 None
 0.89A 1sg9B-1te7A:
undetectable		 1sg9B-1te7A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE

(Populus tremula) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		3 ASP A 269
PHE A 141
ASN A 153
 None
 0.84A 1sg9B-1un1A:
undetectable		 1sg9B-1un1A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		3 ASP A  66
PHE A  83
ASN A  62
 None
 0.51A 1sg9B-1w6jA:
undetectable		 1sg9B-1w6jA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5p NEGATIVE ELONGATION
FACTOR E

(Homo sapiens) 		PF00076
(RRM_1) 		3 ASP A  63
PHE A  37
ASN A  82
 None
 0.68A 1sg9B-1x5pA:
undetectable		 1sg9B-1x5pA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtp LMAJ004091AAA

(Leishmania
major) 		PF05891
(Methyltransf_PK) 		3 ASP A  99
PHE A 194
ASN A 110
 None
 0.73A 1sg9B-1xtpA:
9.9		 1sg9B-1xtpA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 ASP A1403
PHE A1490
ASN A1438
 None
 0.85A 1sg9B-2b39A:
undetectable		 1sg9B-2b39A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		3 ASP A 385
PHE A 356
ASN A 378
 None
 0.80A 1sg9B-2b3bA:
undetectable		 1sg9B-2b3bA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhr FTSH

(Thermus
thermophilus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		3 ASP A 287
PHE A 241
ASN A 280
 None
 0.62A 1sg9B-2dhrA:
undetectable		 1sg9B-2dhrA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e30 CALCIUM-BINDING
PROTEIN P22

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 ASP A  39
PHE A  35
ASN A  79
 None
 0.82A 1sg9B-2e30A:
2.3		 1sg9B-2e30A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5a LIPOYLTRANSFERASE 1

(Bos taurus) 		no annotation 3 ASP A 275
PHE A 310
ASN A 302
 None
 0.85A 1sg9B-2e5aA:
2.1		 1sg9B-2e5aA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ASP A 211
PHE A 169
ASN A 165
 None
 0.49A 1sg9B-2e7zA:
undetectable		 1sg9B-2e7zA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is3 RIBONUCLEASE T

(Escherichia
coli) 		PF00929
(RNase_T) 		3 ASP A  23
PHE A 128
ASN A 121
 None
 0.64A 1sg9B-2is3A:
undetectable		 1sg9B-2is3A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jau 5'(3')-DEOXYRIBONUCL
EOTIDASE

(Homo sapiens) 		PF06941
(NT5C) 		3 ASP A 171
PHE A 127
ASN A 123
 None
 0.55A 1sg9B-2jauA:
undetectable		 1sg9B-2jauA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ASP A 218
PHE A 173
ASN A 200
 None
 0.80A 1sg9B-2nyaA:
undetectable		 1sg9B-2nyaA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE

(Agrobacterium
fabrum) 		PF03562
(MltA)
PF06725
(3D) 		3 ASP A  22
PHE A  77
ASN A  68
 None
 0.80A 1sg9B-2pnwA:
undetectable		 1sg9B-2pnwA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz4 PARAPLEGIN

(Homo sapiens) 		PF00004
(AAA) 		3 ASP A 441
PHE A 394
ASN A 434
 None
 0.75A 1sg9B-2qz4A:
3.4		 1sg9B-2qz4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 ASP A 233
PHE A 192
ASN A 188
 None
 0.67A 1sg9B-2r3sA:
13.4		 1sg9B-2r3sA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5k MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
10) 		PF00500
(Late_protein_L1) 		3 ASP A 237
PHE A 244
ASN A 391
 None
 0.71A 1sg9B-2r5kA:
undetectable		 1sg9B-2r5kA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		3 ASP A 295
PHE A 300
ASN A 287
 None
 0.72A 1sg9B-2vg8A:
2.0		 1sg9B-2vg8A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE

(Homo sapiens) 		PF00004
(AAA) 		3 ASP A 710
PHE A 667
ASN A 703
 None
 0.83A 1sg9B-2x8aA:
undetectable		 1sg9B-2x8aA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		3 ASP A 490
PHE A 449
ASN A 483
 None
 0.80A 1sg9B-2xdfA:
undetectable		 1sg9B-2xdfA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		3 ASP A 326
PHE A 321
ASN A 255
 None
 0.88A 1sg9B-3au9A:
2.5		 1sg9B-3au9A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana) 		PF03492
(Methyltransf_7) 		3 ASP A 235
PHE A 365
ASN A 361
 None
 0.75A 1sg9B-3b5iA:
7.4		 1sg9B-3b5iA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ASP A  77
PHE A 120
ASN A  68
 None
 0.66A 1sg9B-3eykA:
undetectable		 1sg9B-3eykA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB

(Escherichia
coli) 		PF04449
(Fimbrial_CS1)
PF07434
(CblD) 		3 ASP A 241
PHE A 167
ASN A 197
 None
 0.76A 1sg9B-3f83A:
undetectable		 1sg9B-3f83A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Clostridium
acetobutylicum) 		PF00155
(Aminotran_1_2) 		3 ASP A 183
PHE A 208
ASN A 114
 None
 0.70A 1sg9B-3ftbA:
4.4		 1sg9B-3ftbA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbk PUTATIVE GLYCOSYL
HYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		3 ASP A 101
PHE A  74
ASN A  98
 None
 0.79A 1sg9B-3hbkA:
undetectable		 1sg9B-3hbkA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwg ACETYLTRANSFERASE,
GNAT FAMILY

(Colwellia
psychrerythraea) 		PF00583
(Acetyltransf_1) 		3 ASP A 112
PHE A 268
ASN A 105
 None
 0.75A 1sg9B-3iwgA:
undetectable		 1sg9B-3iwgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 3 ASP A 321
PHE A 131
ASN A 123
 None
 0.81A 1sg9B-3j4uA:
undetectable		 1sg9B-3j4uA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcx FAB E LIGHT CHAIN

(Rattus
norvegicus) 		PF07686
(V-set) 		3 ASP L  32
PHE L  71
ASN L  51
 None
 0.89A 1sg9B-3jcxL:
undetectable		 1sg9B-3jcxL:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		3 ASP E 292
PHE E 246
ASN E 285
 None
 0.67A 1sg9B-3kdsE:
undetectable		 1sg9B-3kdsE:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc1 PREDICTED
PHOSPHATASE, HAD
FAMILY

(Clostridium
acetobutylicum) 		PF13419
(HAD_2) 		3 ASP A 128
PHE A   7
ASN A   3
 None
 0.64A 1sg9B-3mc1A:
undetectable		 1sg9B-3mc1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN
CAPSID PROTEIN

(Triatoma virus;
Triatoma virus) 		PF08762
(CRPV_capsid)
PF00073
(Rhv) 		3 ASP A  10
PHE C 125
ASN C  64
 None
 0.68A 1sg9B-3napA:
undetectable		 1sg9B-3napA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ofl L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		3 ASP A 240
PHE A 247
ASN A 396
 None
 0.85A 1sg9B-3oflA:
undetectable		 1sg9B-3oflA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvd CAPSID

(Norwalk virus) 		PF08435
(Calici_coat_C) 		3 ASP A 247
PHE A 242
ASN A 443
 None
 0.83A 1sg9B-3pvdA:
undetectable		 1sg9B-3pvdA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgc POSSIBLE PERIPLASMIC
PROTEIN

(Campylobacter
jejuni) 		PF09312
(SurA_N) 		3 ASP A 136
PHE A 143
ASN A 243
 None
 0.73A 1sg9B-3rgcA:
undetectable		 1sg9B-3rgcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy8 ROCR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00563
(EAL) 		3 ASP A 146
PHE A 193
ASN A 153
 None
 0.80A 1sg9B-3sy8A:
undetectable		 1sg9B-3sy8A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacteroides
abscessus) 		PF01182
(Glucosamine_iso) 		3 ASP A 142
PHE A  69
ASN A  65
 None
None
NA  A 248 (-3.4A)
 0.62A 1sg9B-3tx2A:
undetectable		 1sg9B-3tx2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF00180
(Iso_dh) 		3 ASP A  68
PHE A 101
ASN A  40
 None
 0.84A 1sg9B-3uduA:
2.1		 1sg9B-3uduA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		3 ASP A 502
PHE A 499
ASN A 510
 ANP  A2001 (-2.9A)
None
None
 0.79A 1sg9B-3ummA:
undetectable		 1sg9B-3ummA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 ASP A 155
PHE A 128
ASN A 119
 None
 0.88A 1sg9B-3wy2A:
undetectable		 1sg9B-3wy2A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		3 ASP A 258
PHE A 225
ASN A 233
 None
VNL  A 401 ( 4.8A)
None
 0.87A 1sg9B-4eygA:
3.4		 1sg9B-4eygA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr2 1,3-PROPANEDIOL
DEHYDROGENASE

(Oenococcus oeni) 		PF00465
(Fe-ADH) 		3 ASP A 378
PHE A 383
ASN A 296
 None
 0.77A 1sg9B-4fr2A:
3.2		 1sg9B-4fr2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfu FAB 8M2 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASP H  65
PHE H  63
ASN H  82
 None
 0.72A 1sg9B-4hfuH:
undetectable		 1sg9B-4hfuH:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN

(Bacteroides
ovatus) 		PF01833
(TIG) 		3 ASP A 452
PHE A 170
ASN A 154
 None
 0.88A 1sg9B-4hw6A:
undetectable		 1sg9B-4hw6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4j ACP-POLYENE
THIOESTERASE

(Streptomyces
globisporus) 		PF13279
(4HBT_2) 		3 ASP A  77
PHE A  17
ASN A  25
 None
 0.68A 1sg9B-4i4jA:
undetectable		 1sg9B-4i4jA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN

(Streptococcus
gordonii) 		no annotation 3 ASP D 198
PHE D 234
ASN D 238
 None
 0.84A 1sg9B-4igbD:
undetectable		 1sg9B-4igbD:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg2 PHAGE-RELATED
PROTEIN

(Bacillus cereus) 		PF10991
(DUF2815) 		3 ASP A  57
PHE A 135
ASN A  50
 None
 0.76A 1sg9B-4jg2A:
undetectable		 1sg9B-4jg2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		3 ASP A 590
PHE A 595
ASN A 487
 None
 0.85A 1sg9B-4ktpA:
undetectable		 1sg9B-4ktpA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcb CELL DIVISION
PROTEIN CDVC, VPS4

(Acidianus
hospitalis) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 ASP A 227
PHE A 180
ASN A 220
 None
 0.75A 1sg9B-4lcbA:
undetectable		 1sg9B-4lcbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgm VPS4 AAA ATPASE

(Sulfolobus
solfataricus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 ASP A 233
PHE A 186
ASN A 226
 None
 0.73A 1sg9B-4lgmA:
2.6		 1sg9B-4lgmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nyn RIBONUCLEASE HI

(Halobacterium
salinarum) 		PF13456
(RVT_3) 		3 ASP A 117
PHE A  74
ASN A 111
 None
 0.66A 1sg9B-4nynA:
undetectable		 1sg9B-4nynA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3f SPLICEOSOMAL PROTEIN
CWC27

(Chaetomium
thermophilum) 		PF00160
(Pro_isomerase) 		3 ASP A 110
PHE A 156
ASN A 107
 None
 0.87A 1sg9B-4r3fA:
undetectable		 1sg9B-4r3fA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Aliivibrio
fischeri) 		PF00092
(VWA) 		3 ASP A  70
PHE A  68
ASN A  95
 None
 0.79A 1sg9B-4rckA:
undetectable		 1sg9B-4rckA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		3 ASP A 255
PHE A 418
ASN A 345
 None
None
NAG  A 808 (-1.8A)
 0.80A 1sg9B-4tweA:
2.2		 1sg9B-4tweA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8y MEMBRANE-ASSOCIATED
PROGESTERONE
RECEPTOR COMPONENT 1

(Homo sapiens) 		PF00173
(Cyt-b5) 		3 ASP A 140
PHE A 116
ASN A  94
 None
 0.87A 1sg9B-4x8yA:
undetectable		 1sg9B-4x8yA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B

(Anopheles
gambiae) 		PF13855
(LRR_8) 		3 ASP A 300
PHE A 307
ASN A 279
 None
 0.87A 1sg9B-4xgoA:
undetectable		 1sg9B-4xgoA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		3 ASP A 326
PHE A 321
ASN A 255
 None
 0.84A 1sg9B-4y67A:
4.0		 1sg9B-4y67A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH

(Aquifex
aeolicus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		3 ASP A 287
PHE A 240
ASN A 280
 None
 0.86A 1sg9B-4z8xA:
undetectable		 1sg9B-4z8xA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		3 ASP A 252
PHE A 183
ASN A 223
 None
 0.88A 1sg9B-4zxoA:
undetectable		 1sg9B-4zxoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3m CEA1

(Komagataella
pastoris) 		PF10528
(GLEYA) 		3 ASP A 137
PHE A  67
ASN A  57
 NAG  A 501 ( 2.5A)
None
None
 0.88A 1sg9B-5a3mA:
undetectable		 1sg9B-5a3mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8h TYPE III
PANTOTHENATE KINASE

(Burkholderia
cenocepacia) 		PF03309
(Pan_kinase) 		3 ASP A  37
PHE A  32
ASN A  12
 None
None
PAU  A 302 (-4.6A)
 0.76A 1sg9B-5b8hA:
undetectable		 1sg9B-5b8hA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb7 OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		no annotation 3 ASP A 100
PHE A 103
ASN A 172
 None
 0.77A 1sg9B-5cb7A:
undetectable		 1sg9B-5cb7A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 3 ASP B 286
PHE B 508
ASN B 306
 None
 0.86A 1sg9B-5do8B:
undetectable		 1sg9B-5do8B:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb0 NUCLEOPORIN NUP170
NUCLEOPORIN NUP145

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		no annotation
no annotation 		3 ASP B1159
PHE B1176
ASN E 736
 None
 0.81A 1sg9B-5hb0B:
undetectable		 1sg9B-5hb0B:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase)
PF00515
(TPR_1) 		3 ASP A 117
PHE A 161
ASN A 114
 None
 0.86A 1sg9B-5jheA:
undetectable		 1sg9B-5jheA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		3 ASP A 937
PHE A 870
ASN A 930
 None
 0.73A 1sg9B-5mzaA:
undetectable		 1sg9B-5mzaA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 ASP A 353
PHE A 581
ASN A   2
 None
 0.75A 1sg9B-5neuA:
undetectable		 1sg9B-5neuA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 3 ASP A 367
PHE A 418
ASN A 241
 None
 0.68A 1sg9B-5oltA:
undetectable		 1sg9B-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5omc REPLICATION FACTOR A
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A  10
PHE A  15
ASN A  23
 None
 0.88A 1sg9B-5omcA:
undetectable		 1sg9B-5omcA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ore OCTOPINE-BINDING
PERIPLASMIC PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 3 ASP A 197
PHE A 113
ASN A 152
 None
 0.88A 1sg9B-5oreA:
undetectable		 1sg9B-5oreA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syt CAAX PRENYL PROTEASE
1 HOMOLOG

(Homo sapiens) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		3 ASP A 281
PHE A 226
ASN A 265
 DMS  A 521 ( 4.9A)
None
None
 0.73A 1sg9B-5sytA:
undetectable		 1sg9B-5sytA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 3 ASP A 179
PHE A 161
ASN A 172
 None
 0.76A 1sg9B-5tizA:
undetectable		 1sg9B-5tizA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuk TETRACYCLINE
DESTRUCTASE TET(51)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		3 ASP A 289
PHE A 271
ASN A 341
 FAD  A 402 (-3.0A)
None
None
 0.78A 1sg9B-5tukA:
undetectable		 1sg9B-5tukA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubv ATPASE DOMAIN OF
I-AAA PROTEASE

(Thermothelomyces
thermophila) 		no annotation 3 ASP A 134
PHE A  91
ASN A 127
 None
 0.71A 1sg9B-5ubvA:
2.1		 1sg9B-5ubvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 ASP A 208
PHE A 254
ASN A 178
 None
 0.73A 1sg9B-5um6A:
5.8		 1sg9B-5um6A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 ASP A 489
PHE A 484
ASN A 440
 None
LA6  A 704 (-4.6A)
None
 0.86A 1sg9B-5uv2A:
undetectable		 1sg9B-5uv2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 3 ASP A 285
PHE A 233
ASN A 278
 None
 0.81A 1sg9B-5wc2A:
undetectable		 1sg9B-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 3 ASP A 164
PHE A 639
ASN A 215
 None
 0.83A 1sg9B-5x3jA:
undetectable		 1sg9B-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xl6 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ASP A  73
PHE A 116
ASN A  64
 None
 0.71A 1sg9B-5xl6A:
undetectable		 1sg9B-5xl6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A 196
PHE A 224
ASN A 121
 None
 0.82A 1sg9B-5xzwA:
undetectable		 1sg9B-5xzwA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu5 ALGINATE LYASE

(Vibrio
splendidus) 		no annotation 3 ASP A  77
PHE A 106
ASN A 130
 None
 0.84A 1sg9B-5zu5A:
undetectable		 1sg9B-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu6 CBM32 DOMAIN

(Vibrio) 		no annotation 3 ASP A  77
PHE A 106
ASN A 130
 None
 0.85A 1sg9B-5zu6A:
undetectable		 1sg9B-5zu6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A 409
PHE A 366
ASN A 402
 None
 0.68A 1sg9B-6az0A:
2.5		 1sg9B-6az0A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2w PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN

(Campylobacter
jejuni) 		no annotation 3 ASP A 197
PHE A 190
ASN A 310
 None
 0.80A 1sg9B-6b2wA:
undetectable		 1sg9B-6b2wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE

(Escherichia
coli) 		no annotation 3 ASP A 135
PHE A 152
ASN A 140
 MG  A 201 (-2.7A)
None
None
 0.87A 1sg9B-6bffA:
undetectable		 1sg9B-6bffA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c80 CYTOKININ OXIDASE
LUCKX1.1

(Linum
usitatissimum) 		no annotation 3 ASP A 355
PHE A 361
ASN A 301
 None
 0.76A 1sg9B-6c80A:
undetectable		 1sg9B-6c80A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 ASP H 626
PHE H 580
ASN H 619
 None
 0.78A 1sg9B-6chsH:
3.4		 1sg9B-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cqb CHALCONE SYNTHASE

(Piper
methysticum) 		no annotation 3 ASP A  83
PHE A 199
ASN A  80
 None
 0.83A 1sg9B-6cqbA:
undetectable		 1sg9B-6cqbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g96 ACETYLTRANSFERASE

(Salmonella
enterica) 		no annotation 3 ASP B  98
PHE B  61
ASN B  16
 None
 0.82A 1sg9B-6g96B:
undetectable		 1sg9B-6g96B:
undetectable