SIMILAR PATTERNS OF AMINO ACIDS FOR 1SG9_B_SAMB302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 379
GLY A  90
GLY A 354
ILE A 350
ALA A  95
 SCY  A  89 ( 4.6A)
SCY  A  89 ( 2.4A)
SCY  A  89 ( 4.6A)
SCY  A  89 ( 4.5A)
None
 0.98A 1sg9B-1dm3A:
undetectable		 1sg9B-1dm3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dus MJ0882

(Methanocaldococcus
jannaschii) 		PF05175
(MTS) 		6 PHE A  35
THR A  44
GLY A  63
GLY A  65
ILE A  69
PRO A 131
 None
 0.73A 1sg9B-1dusA:
18.7		 1sg9B-1dusA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Escherichia
coli) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 THR A  42
ILE A  71
GLY A  70
GLY A  68
ILE A  63
 None
 0.98A 1sg9B-1f0kA:
2.8		 1sg9B-1f0kA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfd INORGANIC
PYROPHOSPHATASE

(Escherichia
coli) 		PF00719
(Pyrophosphatase) 		5 THR A  75
ILE A  15
GLY A  56
ILE A  85
VAL A  69
 None
 1.04A 1sg9B-1jfdA:
undetectable		 1sg9B-1jfdA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqe HISTAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF13489
(Methyltransf_23) 		6 ILE A  59
GLY A  60
GLY A  62
ILE A 142
SER A  91
GLU A 118
 None
SAH  A 400 (-3.3A)
SAH  A 400 (-3.2A)
SAH  A 400 (-4.1A)
SAH  A 400 (-4.7A)
None
 1.44A 1sg9B-1jqeA:
7.5		 1sg9B-1jqeA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		6 THR A 452
ILE A 109
GLY A 108
GLY A 106
ILE A 448
ALA A 104
 None
 1.37A 1sg9B-1kplA:
undetectable		 1sg9B-1kplA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrk UDP-GLUCOSE
4-EPIMERASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		6 ILE A  12
GLY A  13
GLY A   8
ILE A  78
SER A  36
GLU A 191
 NAD  A 340 (-3.9A)
None
None
None
NAD  A 340 (-2.7A)
None
 1.32A 1sg9B-1lrkA:
5.9		 1sg9B-1lrkA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A 270
ILE A 303
GLY A 304
GLY A 308
ILE A 287
 None
None
FAD  A 459 ( 3.8A)
None
None
 1.00A 1sg9B-1lvlA:
3.6		 1sg9B-1lvlA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		5 ILE A 116
GLY A 567
GLY A 575
ILE A 409
PRO A 120
 None
 0.99A 1sg9B-1ndfA:
undetectable		 1sg9B-1ndfA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		6 ILE A  92
GLY A  93
GLY A  95
ILE A 155
VAL A 117
SER A 118
 None
None
SAM  A1401 (-3.4A)
SAM  A1401 (-4.2A)
None
None
 1.15A 1sg9B-1p91A:
10.3		 1sg9B-1p91A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		5 THR A  99
ILE A 479
GLY A 411
GLU A 483
PRO A  45
 ADP  A1528 (-3.7A)
None
ADP  A1528 (-3.4A)
None
ADP  A1528 (-4.1A)
 1.00A 1sg9B-1q3sA:
undetectable		 1sg9B-1q3sA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr7 PHENYLALANINE-REGULA
TED
3-DEOXY-D-ARABINO-HE
PTULOSONATE-7-PHOSPH
ATE SYNTHASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		5 GLY A 160
GLY A 184
ILE A  43
GLU A  96
ALA A 176
 None
 0.85A 1sg9B-1qr7A:
undetectable		 1sg9B-1qr7A:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		12 PHE A 100
PRO A 102
THR A 106
ILE A 128
GLY A 129
GLY A 131
ILE A 135
VAL A 152
SER A 153
GLU A 179
PRO A 199
ALA A 218
 SAM  A 301 ( 3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.3A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-4.8A)
SAM  A 301 (-4.3A)
None
None
SAM  A 301 ( 4.6A)
SAM  A 301 (-3.3A)
 0.14A 1sg9B-1sg9A:
43.8		 1sg9B-1sg9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		5 THR A 241
ILE A  45
ILE A 238
SER A 214
ALA A  56
 None
 1.04A 1sg9B-1spjA:
undetectable		 1sg9B-1spjA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		5 PHE A1861
ILE A1820
GLY A1886
GLU A1575
ALA A1882
 None
 0.99A 1sg9B-1uyvA:
4.0		 1sg9B-1uyvA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae) 		PF01008
(IF-2B) 		5 THR A 179
GLY A 192
ILE A 198
SER A 189
ALA A 187
 None
 0.89A 1sg9B-1w2wA:
undetectable		 1sg9B-1w2wA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE

(Bacillus
anthracis) 		PF00731
(AIRC) 		5 GLY A  64
GLY A  85
ILE A  61
VAL A  88
ALA A  69
 None
 1.04A 1sg9B-1xmpA:
4.0		 1sg9B-1xmpA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		5 ILE B  11
GLY B  12
GLY B  14
ILE B  20
GLU B 171
 None
FAD  B 800 (-3.3A)
FAD  B 800 (-3.3A)
None
FAD  B 800 (-4.7A)
 0.73A 1sg9B-1y56B:
2.4		 1sg9B-1y56B:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y5e MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Bacillus cereus) 		PF00994
(MoCF_biosynth) 		5 PHE A 109
THR A  82
GLY A 129
GLY A 106
ILE A  91
 None
 1.04A 1sg9B-1y5eA:
undetectable		 1sg9B-1y5eA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zej 3-HYDROXYACYL-COA
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ILE A   6
GLY A   7
ILE A  15
VAL A  30
SER A  31
 None
 0.83A 1sg9B-1zejA:
6.3		 1sg9B-1zejA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 307
GLY A 308
GLY A 312
ILE A 291
GLU A 321
 None
FAD  A 480 (-3.2A)
None
None
None
 0.86A 1sg9B-2a8xA:
2.8		 1sg9B-2a8xA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		7 PRO A  91
THR A  95
GLY A 117
GLY A 119
ILE A 123
PRO A 185
ALA A 206
 SAH  A 300 (-4.0A)
SAH  A 300 ( 4.3A)
SAH  A 300 (-3.4A)
SAH  A 300 (-3.5A)
None
SAH  A 300 ( 3.9A)
SAH  A 300 (-3.4A)
 0.47A 1sg9B-2b3tA:
28.9		 1sg9B-2b3tA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdt BH3686

(Bacillus
halodurans) 		PF13238
(AAA_18) 		6 THR A  18
ILE A 107
GLY A   9
ILE A   7
VAL A 136
GLU A 140
 None
 1.08A 1sg9B-2bdtA:
undetectable		 1sg9B-2bdtA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 PRO A  13
ILE A 261
GLY A 265
GLY A 157
ILE A 274
 None
 0.91A 1sg9B-2ebdA:
undetectable		 1sg9B-2ebdA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN

(Homo sapiens) 		PF05971
(Methyltransf_10) 		6 PRO A  40
ILE A  72
GLY A  73
GLY A  75
VAL A  97
PRO A 149
 SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.2A)
SAH  A 300 (-4.0A)
 0.58A 1sg9B-2h00A:
17.7		 1sg9B-2h00A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 ILE A 400
GLY A 283
GLY A 235
ILE A 216
VAL A  41
ALA A 122
 None
 1.40A 1sg9B-2ix4A:
undetectable		 1sg9B-2ix4A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l52 METHANOSARCINA
ACETIVORANS SAMP1
HOMOLOG

(Methanosarcina
acetivorans) 		PF02597
(ThiS) 		5 THR A  82
ILE A  92
GLY A  91
GLY A  71
ILE A  74
 None
 1.04A 1sg9B-2l52A:
undetectable		 1sg9B-2l52A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus) 		PF04960
(Glutaminase) 		5 ILE A  44
GLY A 275
GLY A 209
VAL A 270
PRO A  47
 None
 1.01A 1sg9B-2pbyA:
undetectable		 1sg9B-2pbyA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw6 UNCHARACTERIZED
PROTEIN YGID

(Escherichia
coli) 		PF02900
(LigB) 		5 GLY A  21
GLY A 173
VAL A 126
SER A 123
ALA A 171
 None
 1.00A 1sg9B-2pw6A:
undetectable		 1sg9B-2pw6A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		5 THR A  17
ILE A  92
GLY A  91
GLY A  74
ALA A  88
 None
 1.04A 1sg9B-2v9iA:
undetectable		 1sg9B-2v9iA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwq GLUCOSE
DEHYDROGENASE

(Haloferax
mediterranei) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		6 PRO A  53
GLY A  62
GLY A 122
ILE A 117
SER A 125
ALA A   5
 None
 1.19A 1sg9B-2vwqA:
4.1		 1sg9B-2vwqA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		5 THR A 254
ILE A 179
GLY A 188
VAL A 231
ALA A 170
 None
 0.91A 1sg9B-2ww2A:
undetectable		 1sg9B-2ww2A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		5 THR A 335
ILE A 263
GLY A 262
ILE A 332
VAL A 198
 None
 0.80A 1sg9B-2yevA:
undetectable		 1sg9B-2yevA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN

(Yersinia pestis) 		no annotation 5 GLY X 176
GLY X 174
VAL X 194
GLU X 195
ALA X 182
 None
 1.01A 1sg9B-2z22X:
undetectable		 1sg9B-2z22X:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 THR O 381
GLY O 303
GLY O 260
ILE O 299
ALA O 403
 None
 1.01A 1sg9B-2zf5O:
undetectable		 1sg9B-2zf5O:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 GLY A 495
GLY A 506
VAL A 501
GLU A 498
ALA A 574
 None
 1.01A 1sg9B-3b9eA:
2.0		 1sg9B-3b9eA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 PHE A  52
ILE A  33
GLY A  30
GLY A  27
ILE A  24
 None
None
None
FAD  A 609 (-3.4A)
FAD  A 609 (-4.6A)
 1.04A 1sg9B-3da1A:
undetectable		 1sg9B-3da1A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb8 CYSTEINE
PROTEASE-LIKE VIRA

(Shigella
flexneri) 		PF06872
(EspG) 		5 ILE A 353
GLY A 357
GLY A 143
PRO A 150
ALA A 151
 None
 1.03A 1sg9B-3eb8A:
undetectable		 1sg9B-3eb8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		5 ILE A  40
GLY A  41
GLY A  43
ILE A 100
SER A  64
 None
EDO  A 261 (-3.2A)
EDO  A 261 ( 3.9A)
None
None
 0.87A 1sg9B-3egeA:
4.1		 1sg9B-3egeA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		5 ILE A  87
GLY A  88
GLY A  90
VAL A 112
PRO A 157
 None
 0.49A 1sg9B-3evzA:
18.2		 1sg9B-3evzA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsc QDTC

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00132
(Hexapep) 		5 PRO A 161
ILE A 173
GLY A 170
ILE A 189
VAL A 125
 None
 1.03A 1sg9B-3fscA:
undetectable		 1sg9B-3fscA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 PRO A 291
GLY A 207
GLY A 205
ILE A  86
ALA A 283
 None
 0.97A 1sg9B-3h09A:
undetectable		 1sg9B-3h09A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2d CHEC-LIKE
SUPERFAMILY PROTEIN

(Shewanella
oneidensis) 		PF13690
(CheX) 		5 ILE A  59
GLY A  44
ILE A  46
VAL A  42
SER A 120
 None
 0.96A 1sg9B-3h2dA:
undetectable		 1sg9B-3h2dA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihj ALANINE
AMINOTRANSFERASE 2

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 PRO A 377
ILE A 387
GLY A 351
ILE A 159
SER A 340
 None
None
None
None
PLP  A   1 ( 4.1A)
 0.90A 1sg9B-3ihjA:
4.1		 1sg9B-3ihjA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER

(Porphyromonas
gingivalis) 		PF12704
(MacB_PCD) 		5 ILE A 153
GLY A 185
GLY A 139
ILE A 137
ALA A 144
 None
 0.99A 1sg9B-3is6A:
undetectable		 1sg9B-3is6A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwj HEN1

(Trichormus
variabilis) 		PF08242
(Methyltransf_12) 		5 GLY A 288
GLY A 290
ILE A 360
VAL A 312
SER A 313
 None
 0.99A 1sg9B-3jwjA:
12.2		 1sg9B-3jwjA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		5 PRO A 124
THR A 133
ILE A 108
GLY A 129
GLY A 126
 5AD  A1500 ( 4.8A)
None
None
None
None
 0.97A 1sg9B-3koyA:
undetectable		 1sg9B-3koyA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 5 ILE A 167
GLY A 166
GLY A 206
GLU A 194
PRO A 138
 None
 0.94A 1sg9B-3n6zA:
undetectable		 1sg9B-3n6zA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 ILE A 351
GLY A 236
GLY A 190
ILE A 171
VAL A  14
ALA A  78
 None
 1.37A 1sg9B-3o04A:
undetectable		 1sg9B-3o04A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 ILE A 351
GLY A 236
GLY A 190
ILE A 171
VAL A  14
ALA A  82
 None
 1.24A 1sg9B-3o04A:
undetectable		 1sg9B-3o04A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Rubrobacter
xylanophilus) 		PF00535
(Glycos_transf_2) 		6 PRO A  49
GLY A 226
GLY A 116
VAL A 323
GLU A 321
ALA A 112
 GDD  A 340 (-4.8A)
None
None
None
None
None
 1.09A 1sg9B-3o3pA:
undetectable		 1sg9B-3o3pA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r68 NA(+)/H(+) EXCHANGE
REGULATORY COFACTOR
NHE-RF3

(Mus musculus) 		PF00595
(PDZ) 		5 THR A 315
ILE A 271
GLY A 254
GLY A 252
ILE A 246
 None
None
EDO  A   3 (-3.5A)
CL  A   9 ( 3.4A)
None
 1.01A 1sg9B-3r68A:
undetectable		 1sg9B-3r68A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 PHE A 407
THR A 170
ILE A  21
GLY A 399
ALA A 208
 None
 0.99A 1sg9B-3t3oA:
undetectable		 1sg9B-3t3oA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		5 PRO A 287
ILE A 338
GLY A 342
VAL A 365
ALA A 348
 None
 0.94A 1sg9B-3vscA:
3.4		 1sg9B-3vscA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Thermococcus
kodakarensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLY A 177
GLY A 174
SER A 259
GLU A 185
PRO A 333
 None
None
PGE  A 417 (-2.8A)
None
None
 0.95A 1sg9B-3wjpA:
undetectable		 1sg9B-3wjpA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmb GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 GLY A 139
GLY A  21
ILE A 149
SER A  54
PRO A  18
 None
 0.81A 1sg9B-4bmbA:
undetectable		 1sg9B-4bmbA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
PF17243
(POTRA_TamA_1) 		5 PRO A 464
ILE A 484
GLY A 495
VAL A 526
SER A 527
 None
 0.96A 1sg9B-4c00A:
undetectable		 1sg9B-4c00A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		6 PHE A 208
GLY A 236
GLY A 238
ILE A 242
SER A 261
PRO A 307
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-4.7A)
None
SAM  A 401 (-4.0A)
 0.49A 1sg9B-4dcmA:
17.1		 1sg9B-4dcmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 THR A 140
ILE A  56
GLY A  17
GLY A  27
SER A  29
 None
 0.97A 1sg9B-4dgjA:
undetectable		 1sg9B-4dgjA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgs PROBABLE
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		5 THR A 184
GLY A 137
ILE A  19
SER A 154
ALA A 140
 None
 0.99A 1sg9B-4fgsA:
7.1		 1sg9B-4fgsA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqz GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 GLY A 139
GLY A  21
ILE A 149
SER A  54
PRO A  18
 None
EDO  A 412 (-3.1A)
None
EDO  A 412 ( 4.8A)
None
 0.76A 1sg9B-4fqzA:
undetectable		 1sg9B-4fqzA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdn PROTEIN FLP

(Staphylococcus
aureus) 		PF00144
(Beta-lactamase) 		6 PRO A  88
THR A 271
ILE A  56
GLY A  58
ILE A  61
ALA A 240
 None
 1.43A 1sg9B-4gdnA:
undetectable		 1sg9B-4gdnA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		6 PHE A 341
GLY A  21
GLY A  18
ILE A 337
GLU A 387
ALA A  13
 None
 1.46A 1sg9B-4j3zA:
undetectable		 1sg9B-4j3zA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 184
GLY A 202
ILE A 200
SER A 120
ALA A 250
 None
 0.91A 1sg9B-4jgaA:
undetectable		 1sg9B-4jgaA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 ILE A 366
GLY A 251
GLY A 203
ILE A 184
VAL A  18
ALA A  94
 None
 1.31A 1sg9B-4jgaA:
undetectable		 1sg9B-4jgaA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
putida) 		PF00899
(ThiF)
PF08501
(Shikimate_dh_N) 		5 ILE A 131
GLY A 132
GLY A 134
ILE A 140
SER A 158
 MN  A 302 (-4.6A)
NAD  A 301 (-3.4A)
NAD  A 301 (-3.2A)
None
None
 0.96A 1sg9B-4k28A:
6.9		 1sg9B-4k28A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
putida) 		PF00899
(ThiF)
PF08501
(Shikimate_dh_N) 		5 ILE A 131
GLY A 132
ILE A 140
SER A 158
PRO A 196
 MN  A 302 (-4.6A)
NAD  A 301 (-3.4A)
None
None
NAD  A 301 (-4.5A)
 0.68A 1sg9B-4k28A:
6.9		 1sg9B-4k28A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmb CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		5 THR A 161
ILE A 177
GLY A 178
ILE A 189
PRO A 296
 None
None
None
None
PLP  A 403 (-4.1A)
 1.03A 1sg9B-4lmbA:
3.1		 1sg9B-4lmbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		5 PRO A  75
ILE A  24
GLY A  22
GLY A 153
ALA A 257
 None
FDA  A 801 (-3.7A)
FDA  A 801 (-3.2A)
None
None
 1.01A 1sg9B-4mifA:
2.8		 1sg9B-4mifA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3

(Brucella
melitensis) 		PF13458
(Peripla_BP_6) 		5 THR A 318
ILE A  55
GLY A  60
GLY A  63
ILE A  25
 None
 1.03A 1sg9B-4n0qA:
2.8		 1sg9B-4n0qA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		5 PRO A 464
ILE A 484
GLY A 495
VAL A 526
SER A 527
 None
 0.94A 1sg9B-4n74A:
undetectable		 1sg9B-4n74A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 381
GLY A  91
GLY A 356
ILE A 352
ALA A  96
 None
 0.88A 1sg9B-4nzsA:
undetectable		 1sg9B-4nzsA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o99 ACETYL-COA
ACETYLTRANSFERASE

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 380
GLY A  89
GLY A 355
ILE A 351
ALA A  94
 None
 0.92A 1sg9B-4o99A:
undetectable		 1sg9B-4o99A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oja SUPEROXIDE DISMUTASE
[CU-ZN]

(Hydra vulgaris) 		PF00080
(Sod_Cu) 		5 PHE A  49
ILE A 112
GLY A 113
GLY A  50
ILE A  46
 None
 1.03A 1sg9B-4ojaA:
undetectable		 1sg9B-4ojaA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtu PUTATIVE
METHYLTRANSFERASE
BUD23

(Saccharomyces
cerevisiae) 		PF08241
(Methyltransf_11) 		5 THR B  36
ILE B  54
GLY B  55
GLY B  57
SER B  79
 None
None
SAM  B 301 (-3.7A)
SAM  B 301 (-3.3A)
EDO  B 310 ( 3.0A)
 0.87A 1sg9B-4qtuB:
11.4		 1sg9B-4qtuB:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 ILE A 170
GLY A 166
GLY A 343
ILE A 159
VAL A 348
ALA A 190
 None
 1.32A 1sg9B-4r8eA:
undetectable		 1sg9B-4r8eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Desulfitobacterium
hafniense) 		PF13472
(Lipase_GDSL_2) 		6 THR A  64
ILE A 126
GLY A 123
GLY A 121
VAL A 129
ALA A  97
 None
 1.48A 1sg9B-4rshA:
undetectable		 1sg9B-4rshA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvw GALECTIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		5 GLY A 138
GLY A  20
ILE A 148
SER A  53
PRO A  17
 None
 0.81A 1sg9B-4wvwA:
undetectable		 1sg9B-4wvwA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		5 THR A 345
ILE A 206
GLY A 333
ILE A  15
SER A 224
 None
None
None
FAD  A 401 (-3.9A)
None
 0.95A 1sg9B-4yshA:
3.3		 1sg9B-4yshA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxz LEVOGLUCOSAN KINASE

(Lipomyces
starkeyi) 		PF03702
(AnmK) 		5 THR A 144
ILE A 149
GLY A 111
ILE A 140
GLU A 372
 None
 0.93A 1sg9B-4zxzA:
undetectable		 1sg9B-4zxzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5agt LEUCINE--TRNA LIGASE

(Mycobacterium
tuberculosis) 		PF13603
(tRNA-synt_1_2) 		5 THR A 341
ILE A 480
GLY A 479
GLY A 477
PRO A 493
 A2H  A1514 (-3.6A)
None
None
None
None
 0.98A 1sg9B-5agtA:
undetectable		 1sg9B-5agtA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE

(Methanospirillum
hungatei) 		PF00485
(PRK) 		5 PHE A 243
THR A 270
GLY A 298
ILE A 296
SER A 197
 None
 0.98A 1sg9B-5b3fA:
2.2		 1sg9B-5b3fA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwa ORNITHINE
DECARBOXYLASE

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 PRO A 113
THR A 132
ILE A 234
GLY A 235
ALA A  67
 PLP  A 600 ( 4.9A)
None
None
None
PLP  A 600 ( 3.8A)
 0.93A 1sg9B-5bwaA:
undetectable		 1sg9B-5bwaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjj PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Campylobacter
jejuni) 		PF00551
(Formyl_trans_N) 		5 THR A  58
GLY A  11
GLY A  13
ILE A  48
ALA A  91
 None
 0.90A 1sg9B-5cjjA:
3.8		 1sg9B-5cjjA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 PHE A1861
ILE A1820
GLY A1886
GLU A1575
ALA A1882
 None
 1.00A 1sg9B-5cslA:
2.9		 1sg9B-5cslA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		5 ILE A 342
GLY A 343
VAL A  93
PRO A 418
ALA A 125
 None
 0.89A 1sg9B-5djsA:
2.9		 1sg9B-5djsA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm2 O-METHYLRANSFERASE

(Streptomyces
blastmyceticus) 		PF08241
(Methyltransf_11) 		6 ILE A  84
GLY A  85
GLY A  87
ILE A 152
VAL A 108
SER A 109
 None
SAH  A 301 (-3.2A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.2A)
None
 1.10A 1sg9B-5gm2A:
11.0		 1sg9B-5gm2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]

(Thermotoga
maritima) 		PF03060
(NMO) 		5 GLY A  44
GLY A  21
ILE A  73
GLU A  59
ALA A  25
 None
FMN  A 402 (-4.2A)
FMN  A 402 (-4.9A)
None
FMN  A 402 ( 4.6A)
 1.02A 1sg9B-5gvhA:
undetectable		 1sg9B-5gvhA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzg GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 GLY A 139
GLY A  21
ILE A 149
SER A  54
PRO A  18
 None
 0.85A 1sg9B-5gzgA:
undetectable		 1sg9B-5gzgA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h35 MEMBRANE PROTEIN
TRIC

(Sulfolobus
solfataricus) 		PF03458
(UPF0126) 		5 PHE C  16
THR C 103
ILE C  11
VAL C  77
SER C  74
 None
 1.00A 1sg9B-5h35C:
2.3		 1sg9B-5h35C:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik8 LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		5 ILE A2986
GLY A2985
GLY A3073
VAL A2976
SER A2977
 None
 0.95A 1sg9B-5ik8A:
undetectable		 1sg9B-5ik8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 ILE L 245
GLY L 246
GLY L 163
ILE L 159
ALA L 455
 None
None
FAD  L 503 (-3.2A)
None
FAD  L 503 (-3.5A)
 0.94A 1sg9B-5jfcL:
2.8		 1sg9B-5jfcL:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l73 NEUROPILIN-1

(Homo sapiens) 		PF00629
(MAM) 		5 ILE A 793
GLY A 792
GLY A 791
ILE A 683
GLU A 784
 None
 1.04A 1sg9B-5l73A:
undetectable		 1sg9B-5l73A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN

(Cupriavidus
necator) 		PF03807
(F420_oxidored)
PF16896
(PGDH_C) 		5 GLY A   9
GLY A  11
VAL A  34
SER A  35
PRO A  68
 NAD  A 301 (-3.4A)
NAD  A 301 (-4.3A)
NAD  A 301 (-4.4A)
NAD  A 301 ( 3.9A)
NAD  A 301 (-4.2A)
 0.91A 1sg9B-5t57A:
5.0		 1sg9B-5t57A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 ILE A 245
GLY A 246
GLY A 163
ILE A 159
ALA A 456
 None
None
FAD  A 503 (-3.4A)
None
FAD  A 503 (-2.7A)
 0.97A 1sg9B-5vj7A:
3.0		 1sg9B-5vj7A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vq5 ADHESIN

(Escherichia
coli) 		no annotation 5 ILE A  95
GLY A  94
ILE A  68
VAL A  90
SER A  91
 None
 0.75A 1sg9B-5vq5A:
undetectable		 1sg9B-5vq5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III

(Komagataella
phaffii) 		no annotation 5 PRO A 319
ILE A 178
GLY A 186
GLY A 184
ALA A 157
 None
 0.83A 1sg9B-5yatA:
6.4		 1sg9B-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apg DISD PROTEIN

(Sorangium
cellulosum) 		no annotation 5 ILE A 166
GLY A 122
GLY A 120
VAL A 186
SER A 187
 None
None
GOL  A 302 (-3.6A)
None
None
 1.04A 1sg9B-6apgA:
undetectable		 1sg9B-6apgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE

(Homo sapiens) 		no annotation 5 PRO A  77
ILE A 109
GLY A 110
GLY A 112
VAL A 134
 SAH  A 305 ( 4.8A)
None
SAH  A 305 (-3.1A)
SAH  A 305 (-3.4A)
SAH  A 305 (-4.1A)
 0.40A 1sg9B-6b92A:
16.7		 1sg9B-6b92A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Legionella
pneumophila) 		no annotation 5 THR A 121
ILE A 164
GLY A 153
ILE A 134
VAL A 196
 None
 1.03A 1sg9B-6cktA:
undetectable		 1sg9B-6cktA:
undetectable