SIMILAR PATTERNS OF AMINO ACIDS FOR 1SG9_B_SAMB302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 379
GLY A  90
GLY A 354
ILE A 350
ALA A  95
 SCY  A  89 ( 4.6A)
SCY  A  89 ( 2.4A)
SCY  A  89 ( 4.6A)
SCY  A  89 ( 4.5A)
None
 0.98A 1sg9B-1dm3A:
undetectable		 1sg9B-1dm3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dus MJ0882

(Methanocaldococcus
jannaschii) 		PF05175
(MTS) 		6 PHE A  35
THR A  44
GLY A  63
GLY A  65
ILE A  69
PRO A 131
 None
 0.73A 1sg9B-1dusA:
18.7		 1sg9B-1dusA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Escherichia
coli) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 THR A  42
ILE A  71
GLY A  70
GLY A  68
ILE A  63
 None
 0.98A 1sg9B-1f0kA:
2.8		 1sg9B-1f0kA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfd INORGANIC
PYROPHOSPHATASE

(Escherichia
coli) 		PF00719
(Pyrophosphatase) 		5 THR A  75
ILE A  15
GLY A  56
ILE A  85
VAL A  69
 None
 1.04A 1sg9B-1jfdA:
undetectable		 1sg9B-1jfdA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqe HISTAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF13489
(Methyltransf_23) 		6 ILE A  59
GLY A  60
GLY A  62
ILE A 142
SER A  91
GLU A 118
 None
SAH  A 400 (-3.3A)
SAH  A 400 (-3.2A)
SAH  A 400 (-4.1A)
SAH  A 400 (-4.7A)
None
 1.44A 1sg9B-1jqeA:
7.5		 1sg9B-1jqeA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		6 THR A 452
ILE A 109
GLY A 108
GLY A 106
ILE A 448
ALA A 104
 None
 1.37A 1sg9B-1kplA:
undetectable		 1sg9B-1kplA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrk UDP-GLUCOSE
4-EPIMERASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		6 ILE A  12
GLY A  13
GLY A   8
ILE A  78
SER A  36
GLU A 191
 NAD  A 340 (-3.9A)
None
None
None
NAD  A 340 (-2.7A)
None
 1.32A 1sg9B-1lrkA:
5.9		 1sg9B-1lrkA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A 270
ILE A 303
GLY A 304
GLY A 308
ILE A 287
 None
None
FAD  A 459 ( 3.8A)
None
None
 1.00A 1sg9B-1lvlA:
3.6		 1sg9B-1lvlA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		5 ILE A 116
GLY A 567
GLY A 575
ILE A 409
PRO A 120
 None
 0.99A 1sg9B-1ndfA:
undetectable		 1sg9B-1ndfA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		6 ILE A  92
GLY A  93
GLY A  95
ILE A 155
VAL A 117
SER A 118
 None
None
SAM  A1401 (-3.4A)
SAM  A1401 (-4.2A)
None
None
 1.15A 1sg9B-1p91A:
10.3		 1sg9B-1p91A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		5 THR A  99
ILE A 479
GLY A 411
GLU A 483
PRO A  45
 ADP  A1528 (-3.7A)
None
ADP  A1528 (-3.4A)
None
ADP  A1528 (-4.1A)
 1.00A 1sg9B-1q3sA:
undetectable		 1sg9B-1q3sA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr7 PHENYLALANINE-REGULA
TED
3-DEOXY-D-ARABINO-HE
PTULOSONATE-7-PHOSPH
ATE SYNTHASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		5 GLY A 160
GLY A 184
ILE A  43
GLU A  96
ALA A 176
 None
 0.85A 1sg9B-1qr7A:
undetectable		 1sg9B-1qr7A:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		12 PHE A 100
PRO A 102
THR A 106
ILE A 128
GLY A 129
GLY A 131
ILE A 135
VAL A 152
SER A 153
GLU A 179
PRO A 199
ALA A 218
 SAM  A 301 ( 3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.3A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-4.8A)
SAM  A 301 (-4.3A)
None
None
SAM  A 301 ( 4.6A)
SAM  A 301 (-3.3A)
 0.14A 1sg9B-1sg9A:
43.8		 1sg9B-1sg9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		5 THR A 241
ILE A  45
ILE A 238
SER A 214
ALA A  56
 None
 1.04A 1sg9B-1spjA:
undetectable		 1sg9B-1spjA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		5 PHE A1861
ILE A1820
GLY A1886
GLU A1575
ALA A1882
 None
 0.99A 1sg9B-1uyvA:
4.0		 1sg9B-1uyvA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae) 		PF01008
(IF-2B) 		5 THR A 179
GLY A 192
ILE A 198
SER A 189
ALA A 187
 None
 0.89A 1sg9B-1w2wA:
undetectable		 1sg9B-1w2wA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE

(Bacillus
anthracis) 		PF00731
(AIRC) 		5 GLY A  64
GLY A  85
ILE A  61
VAL A  88
ALA A  69
 None
 1.04A 1sg9B-1xmpA:
4.0		 1sg9B-1xmpA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		5 ILE B  11
GLY B  12
GLY B  14
ILE B  20
GLU B 171
 None
FAD  B 800 (-3.3A)
FAD  B 800 (-3.3A)
None
FAD  B 800 (-4.7A)
 0.73A 1sg9B-1y56B:
2.4		 1sg9B-1y56B:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y5e MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Bacillus cereus) 		PF00994
(MoCF_biosynth) 		5 PHE A 109
THR A  82
GLY A 129
GLY A 106
ILE A  91
 None
 1.04A 1sg9B-1y5eA:
undetectable		 1sg9B-1y5eA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zej 3-HYDROXYACYL-COA
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ILE A   6
GLY A   7
ILE A  15
VAL A  30
SER A  31
 None
 0.83A 1sg9B-1zejA:
6.3		 1sg9B-1zejA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 307
GLY A 308
GLY A 312
ILE A 291
GLU A 321
 None
FAD  A 480 (-3.2A)
None
None
None
 0.86A 1sg9B-2a8xA:
2.8		 1sg9B-2a8xA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		7 PRO A  91
THR A  95
GLY A 117
GLY A 119
ILE A 123
PRO A 185
ALA A 206
 SAH  A 300 (-4.0A)
SAH  A 300 ( 4.3A)
SAH  A 300 (-3.4A)
SAH  A 300 (-3.5A)
None
SAH  A 300 ( 3.9A)
SAH  A 300 (-3.4A)
 0.47A 1sg9B-2b3tA:
28.9		 1sg9B-2b3tA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdt BH3686

(Bacillus
halodurans) 		PF13238
(AAA_18) 		6 THR A  18
ILE A 107
GLY A   9
ILE A   7
VAL A 136
GLU A 140
 None
 1.08A 1sg9B-2bdtA:
undetectable		 1sg9B-2bdtA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 PRO A  13
ILE A 261
GLY A 265
GLY A 157
ILE A 274
 None
 0.91A 1sg9B-2ebdA:
undetectable		 1sg9B-2ebdA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN

(Homo sapiens) 		PF05971
(Methyltransf_10) 		6 PRO A  40
ILE A  72
GLY A  73
GLY A  75
VAL A  97
PRO A 149
 SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.2A)
SAH  A 300 (-4.0A)
 0.58A 1sg9B-2h00A:
17.7		 1sg9B-2h00A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 ILE A 400
GLY A 283
GLY A 235
ILE A 216
VAL A  41
ALA A 122
 None
 1.40A 1sg9B-2ix4A:
undetectable		 1sg9B-2ix4A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l52 METHANOSARCINA
ACETIVORANS SAMP1
HOMOLOG

(Methanosarcina
acetivorans) 		PF02597
(ThiS) 		5 THR A  82
ILE A  92
GLY A  91
GLY A  71
ILE A  74
 None
 1.04A 1sg9B-2l52A:
undetectable		 1sg9B-2l52A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus) 		PF04960
(Glutaminase) 		5 ILE A  44
GLY A 275
GLY A 209
VAL A 270
PRO A  47
 None
 1.01A 1sg9B-2pbyA:
undetectable		 1sg9B-2pbyA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw6 UNCHARACTERIZED
PROTEIN YGID

(Escherichia
coli) 		PF02900
(LigB) 		5 GLY A  21
GLY A 173
VAL A 126
SER A 123
ALA A 171
 None
 1.00A 1sg9B-2pw6A:
undetectable		 1sg9B-2pw6A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		5 THR A  17
ILE A  92
GLY A  91
GLY A  74
ALA A  88
 None
 1.04A 1sg9B-2v9iA:
undetectable		 1sg9B-2v9iA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwq GLUCOSE
DEHYDROGENASE

(Haloferax
mediterranei) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		6 PRO A  53
GLY A  62
GLY A 122
ILE A 117
SER A 125
ALA A   5
 None
 1.19A 1sg9B-2vwqA:
4.1		 1sg9B-2vwqA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		5 THR A 254
ILE A 179
GLY A 188
VAL A 231
ALA A 170
 None
 0.91A 1sg9B-2ww2A:
undetectable		 1sg9B-2ww2A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		5 THR A 335
ILE A 263
GLY A 262
ILE A 332
VAL A 198
 None
 0.80A 1sg9B-2yevA:
undetectable		 1sg9B-2yevA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN

(Yersinia pestis) 		no annotation 5 GLY X 176
GLY X 174
VAL X 194
GLU X 195
ALA X 182
 None
 1.01A 1sg9B-2z22X:
undetectable		 1sg9B-2z22X:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 THR O 381
GLY O 303
GLY O 260
ILE O 299
ALA O 403
 None
 1.01A 1sg9B-2zf5O:
undetectable		 1sg9B-2zf5O:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 GLY A 495
GLY A 506
VAL A 501
GLU A 498
ALA A 574
 None
 1.01A 1sg9B-3b9eA:
2.0		 1sg9B-3b9eA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 PHE A  52
ILE A  33
GLY A  30
GLY A  27
ILE A  24
 None
None
None
FAD  A 609 (-3.4A)
FAD  A 609 (-4.6A)
 1.04A 1sg9B-3da1A:
undetectable		 1sg9B-3da1A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb8 CYSTEINE
PROTEASE-LIKE VIRA

(Shigella
flexneri) 		PF06872
(EspG) 		5 ILE A 353
GLY A 357
GLY A 143
PRO A 150
ALA A 151
 None
 1.03A 1sg9B-3eb8A:
undetectable		 1sg9B-3eb8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		5 ILE A  40
GLY A  41
GLY A  43
ILE A 100
SER A  64
 None
EDO  A 261 (-3.2A)
EDO  A 261 ( 3.9A)
None
None
 0.87A 1sg9B-3egeA:
4.1		 1sg9B-3egeA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		5 ILE A  87
GLY A  88
GLY A  90
VAL A 112
PRO A 157
 None
 0.49A 1sg9B-3evzA:
18.2		 1sg9B-3evzA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsc QDTC

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00132
(Hexapep) 		5 PRO A 161
ILE A 173
GLY A 170
ILE A 189
VAL A 125
 None
 1.03A 1sg9B-3fscA:
undetectable		 1sg9B-3fscA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 PRO A 291
GLY A 207
GLY A 205
ILE A  86
ALA A 283
 None
 0.97A 1sg9B-3h09A:
undetectable		 1sg9B-3h09A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2d CHEC-LIKE
SUPERFAMILY PROTEIN

(Shewanella
oneidensis) 		PF13690
(CheX) 		5 ILE A  59
GLY A  44
ILE A  46
VAL A  42
SER A 120
 None
 0.96A 1sg9B-3h2dA:
undetectable		 1sg9B-3h2dA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihj ALANINE
AMINOTRANSFERASE 2

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 PRO A 377
ILE A 387
GLY A 351
ILE A 159
SER A 340
 None
None
None
None
PLP  A   1 ( 4.1A)
 0.90A 1sg9B-3ihjA:
4.1		 1sg9B-3ihjA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER

(Porphyromonas
gingivalis) 		PF12704
(MacB_PCD) 		5 ILE A 153
GLY A 185
GLY A 139
ILE A 137
ALA A 144
 None
 0.99A 1sg9B-3is6A:
undetectable		 1sg9B-3is6A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwj HEN1

(Trichormus
variabilis) 		PF08242
(Methyltransf_12) 		5 GLY A 288
GLY A 290
ILE A 360
VAL A 312
SER A 313
 None
 0.99A 1sg9B-3jwjA:
12.2		 1sg9B-3jwjA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		5 PRO A 124
THR A 133
ILE A 108
GLY A 129
GLY A 126
 5AD  A1500 ( 4.8A)
None
None
None
None
 0.97A 1sg9B-3koyA:
undetectable		 1sg9B-3koyA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 5 ILE A 167
GLY A 166
GLY A 206
GLU A 194
PRO A 138
 None
 0.94A 1sg9B-3n6zA:
undetectable		 1sg9B-3n6zA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 ILE A 351
GLY A 236
GLY A 190
ILE A 171
VAL A  14
ALA A  78
 None
 1.37A 1sg9B-3o04A:
undetectable		 1sg9B-3o04A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 ILE A 351
GLY A 236
GLY A 190
ILE A 171
VAL A  14
ALA A  82
 None
 1.24A 1sg9B-3o04A:
undetectable		 1sg9B-3o04A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Rubrobacter
xylanophilus) 		PF00535
(Glycos_transf_2) 		6 PRO A  49
GLY A 226
GLY A 116
VAL A 323
GLU A 321
ALA A 112
 GDD  A 340 (-4.8A)
None
None
None
None
None
 1.09A 1sg9B-3o3pA:
undetectable		 1sg9B-3o3pA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r68 NA(+)/H(+) EXCHANGE
REGULATORY COFACTOR
NHE-RF3

(Mus musculus) 		PF00595
(PDZ) 		5 THR A 315
ILE A 271
GLY A 254
GLY A 252
ILE A 246
 None
None
EDO  A   3 (-3.5A)
CL  A   9 ( 3.4A)
None
 1.01A 1sg9B-3r68A:
undetectable		 1sg9B-3r68A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 PHE A 407
THR A 170
ILE A  21
GLY A 399
ALA A 208
 None
 0.99A 1sg9B-3t3oA:
undetectable		 1sg9B-3t3oA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		5 PRO A 287
ILE A 338
GLY A 342
VAL A 365
ALA A 348
 None
 0.94A 1sg9B-3vscA:
3.4		 1sg9B-3vscA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Thermococcus
kodakarensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLY A 177
GLY A 174
SER A 259
GLU A 185
PRO A 333
 None
None
PGE  A 417 (-2.8A)
None
None
 0.95A 1sg9B-3wjpA:
undetectable		 1sg9B-3wjpA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmb GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 GLY A 139
GLY A  21
ILE A 149
SER A  54
PRO A  18
 None
 0.81A 1sg9B-4bmbA:
undetectable		 1sg9B-4bmbA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
PF17243
(POTRA_TamA_1) 		5 PRO A 464
ILE A 484
GLY A 495
VAL A 526
SER A 527
 None
 0.96A 1sg9B-4c00A:
undetectable		 1sg9B-4c00A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		6 PHE A 208
GLY A 236
GLY A 238
ILE A 242
SER A 261
PRO A 307
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-4.7A)
None
SAM  A 401 (-4.0A)
 0.49A 1sg9B-4dcmA:
17.1		 1sg9B-4dcmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 THR A 140
ILE A  56
GLY A  17
GLY A  27
SER A  29
 None
 0.97A 1sg9B-4dgjA:
undetectable		 1sg9B-4dgjA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgs PROBABLE
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		5 THR A 184
GLY A 137
ILE A  19
SER A 154
ALA A 140
 None
 0.99A 1sg9B-4fgsA:
7.1		 1sg9B-4fgsA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqz GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 GLY A 139
GLY A  21
ILE A 149
SER A  54
PRO A  18
 None
EDO  A 412 (-3.1A)
None
EDO  A 412 ( 4.8A)
None
 0.76A 1sg9B-4fqzA:
undetectable		 1sg9B-4fqzA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdn PROTEIN FLP

(Staphylococcus
aureus) 		PF00144
(Beta-lactamase) 		6 PRO A  88
THR A 271
ILE A  56
GLY A  58
ILE A  61
ALA A 240
 None
 1.43A 1sg9B-4gdnA:
undetectable		 1sg9B-4gdnA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		6 PHE A 341
GLY A  21
GLY A  18
ILE A 337
GLU A 387
ALA A  13
 None
 1.46A 1sg9B-4j3zA:
undetectable		 1sg9B-4j3zA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 184
GLY A 202
ILE A 200
SER A 120
ALA A 250
 None
 0.91A 1sg9B-4jgaA:
undetectable		 1sg9B-4jgaA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 ILE A 366
GLY A 251
GLY A 203
ILE A 184
VAL A  18
ALA A  94
 None
 1.31A 1sg9B-4jgaA:
undetectable		 1sg9B-4jgaA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
putida) 		PF00899
(ThiF)
PF08501
(Shikimate_dh_N) 		5 ILE A 131
GLY A 132
GLY A 134
ILE A 140
SER A 158
 MN  A 302 (-4.6A)
NAD  A 301 (-3.4A)
NAD  A 301 (-3.2A)
None
None
 0.96A 1sg9B-4k28A:
6.9		 1sg9B-4k28A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
putida) 		PF00899
(ThiF)
PF08501
(Shikimate_dh_N) 		5 ILE A 131
GLY A 132
ILE A 140
SER A 158
PRO A 196
 MN  A 302 (-4.6A)
NAD  A 301 (-3.4A)
None
None
NAD  A 301 (-4.5A)
 0.68A 1sg9B-4k28A:
6.9		 1sg9B-4k28A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmb CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		5 THR A 161
ILE A 177
GLY A 178
ILE A 189
PRO A 296
 None
None
None
None
PLP  A 403 (-4.1A)
 1.03A 1sg9B-4lmbA:
3.1		 1sg9B-4lmbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		5 PRO A  75
ILE A  24
GLY A  22
GLY A 153
ALA A 257
 None
FDA  A 801 (-3.7A)
FDA  A 801 (-3.2A)
None
None
 1.01A 1sg9B-4mifA:
2.8		 1sg9B-4mifA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3

(Brucella
melitensis) 		PF13458
(Peripla_BP_6) 		5 THR A 318
ILE A  55
GLY A  60
GLY A  63
ILE A  25
 None
 1.03A 1sg9B-4n0qA:
2.8		 1sg9B-4n0qA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		5 PRO A 464
ILE A 484
GLY A 495
VAL A 526
SER A 527
 None
 0.94A 1sg9B-4n74A:
undetectable		 1sg9B-4n74A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 381
GLY A  91
GLY A 356
ILE A 352
ALA A  96
 None
 0.88A 1sg9B-4nzsA:
undetectable		 1sg9B-4nzsA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o99 ACETYL-COA
ACETYLTRANSFERASE

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 380
GLY A  89
GLY A 355
ILE A 351
ALA A  94
 None
 0.92A 1sg9B-4o99A:
undetectable		 1sg9B-4o99A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oja SUPEROXIDE DISMUTASE
[CU-ZN]

(Hydra vulgaris) 		PF00080
(Sod_Cu) 		5 PHE A  49
ILE A 112
GLY A 113
GLY A  50
ILE A  46
 None
 1.03A 1sg9B-4ojaA:
undetectable		 1sg9B-4ojaA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtu PUTATIVE
METHYLTRANSFERASE
BUD23

(Saccharomyces
cerevisiae) 		PF08241
(Methyltransf_11) 		5 THR B  36
ILE B  54
GLY B  55
GLY B  57
SER B  79
 None
None
SAM  B 301 (-3.7A)
SAM  B 301 (-3.3A)
EDO  B 310 ( 3.0A)
 0.87A 1sg9B-4qtuB:
11.4		 1sg9B-4qtuB:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 ILE A 170
GLY A 166
GLY A 343
ILE A 159
VAL A 348
ALA A 190
 None
 1.32A 1sg9B-4r8eA:
undetectable		 1sg9B-4r8eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Desulfitobacterium
hafniense) 		PF13472
(Lipase_GDSL_2) 		6 THR A  64
ILE A 126
GLY A 123
GLY A 121
VAL A 129
ALA A  97
 None
 1.48A 1sg9B-4rshA:
undetectable		 1sg9B-4rshA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvw GALECTIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		5 GLY A 138
GLY A  20
ILE A 148
SER A  53
PRO A  17
 None
 0.81A 1sg9B-4wvwA:
undetectable		 1sg9B-4wvwA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		5 THR A 345
ILE A 206
GLY A 333
ILE A  15
SER A 224
 None
None
None
FAD  A 401 (-3.9A)
None
 0.95A 1sg9B-4yshA:
3.3		 1sg9B-4yshA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxz LEVOGLUCOSAN KINASE

(Lipomyces
starkeyi) 		PF03702
(AnmK) 		5 THR A 144
ILE A 149
GLY A 111
ILE A 140
GLU A 372
 None
 0.93A 1sg9B-4zxzA:
undetectable		 1sg9B-4zxzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5agt LEUCINE--TRNA LIGASE

(Mycobacterium
tuberculosis) 		PF13603
(tRNA-synt_1_2) 		5 THR A 341
ILE A 480
GLY A 479
GLY A 477
PRO A 493
 A2H  A1514 (-3.6A)
None
None
None
None
 0.98A 1sg9B-5agtA:
undetectable		 1sg9B-5agtA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE

(Methanospirillum
hungatei) 		PF00485
(PRK) 		5 PHE A 243
THR A 270
GLY A 298
ILE A 296
SER A 197
 None
 0.98A 1sg9B-5b3fA:
2.2		 1sg9B-5b3fA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwa ORNITHINE
DECARBOXYLASE

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 PRO A 113
THR A 132
ILE A 234
GLY A 235
ALA A  67
 PLP  A 600 ( 4.9A)
None
None
None
PLP  A 600 ( 3.8A)
 0.93A 1sg9B-5bwaA:
undetectable		 1sg9B-5bwaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjj PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Campylobacter
jejuni) 		PF00551
(Formyl_trans_N) 		5 THR A  58
GLY A  11
GLY A  13
ILE A  48
ALA A  91
 None
 0.90A 1sg9B-5cjjA:
3.8		 1sg9B-5cjjA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 PHE A1861
ILE A1820
GLY A1886
GLU A1575
ALA A1882
 None
 1.00A 1sg9B-5cslA:
2.9		 1sg9B-5cslA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		5 ILE A 342
GLY A 343
VAL A  93
PRO A 418
ALA A 125
 None
 0.89A 1sg9B-5djsA:
2.9		 1sg9B-5djsA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm2 O-METHYLRANSFERASE

(Streptomyces
blastmyceticus) 		PF08241
(Methyltransf_11) 		6 ILE A  84
GLY A  85
GLY A  87
ILE A 152
VAL A 108
SER A 109
 None
SAH  A 301 (-3.2A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.2A)
None
 1.10A 1sg9B-5gm2A:
11.0		 1sg9B-5gm2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]

(Thermotoga
maritima) 		PF03060
(NMO) 		5 GLY A  44
GLY A  21
ILE A  73
GLU A  59
ALA A  25
 None
FMN  A 402 (-4.2A)
FMN  A 402 (-4.9A)
None
FMN  A 402 ( 4.6A)
 1.02A 1sg9B-5gvhA:
undetectable		 1sg9B-5gvhA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzg GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 GLY A 139
GLY A  21
ILE A 149
SER A  54
PRO A  18
 None
 0.85A 1sg9B-5gzgA:
undetectable		 1sg9B-5gzgA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h35 MEMBRANE PROTEIN
TRIC

(Sulfolobus
solfataricus) 		PF03458
(UPF0126) 		5 PHE C  16
THR C 103
ILE C  11
VAL C  77
SER C  74
 None
 1.00A 1sg9B-5h35C:
2.3		 1sg9B-5h35C:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik8 LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		5 ILE A2986
GLY A2985
GLY A3073
VAL A2976
SER A2977
 None
 0.95A 1sg9B-5ik8A:
undetectable		 1sg9B-5ik8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 ILE L 245
GLY L 246
GLY L 163
ILE L 159
ALA L 455
 None
None
FAD  L 503 (-3.2A)
None
FAD  L 503 (-3.5A)
 0.94A 1sg9B-5jfcL:
2.8		 1sg9B-5jfcL:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l73 NEUROPILIN-1

(Homo sapiens) 		PF00629
(MAM) 		5 ILE A 793
GLY A 792
GLY A 791
ILE A 683
GLU A 784
 None
 1.04A 1sg9B-5l73A:
undetectable		 1sg9B-5l73A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN

(Cupriavidus
necator) 		PF03807
(F420_oxidored)
PF16896
(PGDH_C) 		5 GLY A   9
GLY A  11
VAL A  34
SER A  35
PRO A  68
 NAD  A 301 (-3.4A)
NAD  A 301 (-4.3A)
NAD  A 301 (-4.4A)
NAD  A 301 ( 3.9A)
NAD  A 301 (-4.2A)
 0.91A 1sg9B-5t57A:
5.0		 1sg9B-5t57A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 ILE A 245
GLY A 246
GLY A 163
ILE A 159
ALA A 456
 None
None
FAD  A 503 (-3.4A)
None
FAD  A 503 (-2.7A)
 0.97A 1sg9B-5vj7A:
3.0		 1sg9B-5vj7A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vq5 ADHESIN

(Escherichia
coli) 		no annotation 5 ILE A  95
GLY A  94
ILE A  68
VAL A  90
SER A  91
 None
 0.75A 1sg9B-5vq5A:
undetectable		 1sg9B-5vq5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III

(Komagataella
phaffii) 		no annotation 5 PRO A 319
ILE A 178
GLY A 186
GLY A 184
ALA A 157
 None
 0.83A 1sg9B-5yatA:
6.4		 1sg9B-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apg DISD PROTEIN

(Sorangium
cellulosum) 		no annotation 5 ILE A 166
GLY A 122
GLY A 120
VAL A 186
SER A 187
 None
None
GOL  A 302 (-3.6A)
None
None
 1.04A 1sg9B-6apgA:
undetectable		 1sg9B-6apgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE

(Homo sapiens) 		no annotation 5 PRO A  77
ILE A 109
GLY A 110
GLY A 112
VAL A 134
 SAH  A 305 ( 4.8A)
None
SAH  A 305 (-3.1A)
SAH  A 305 (-3.4A)
SAH  A 305 (-4.1A)
 0.40A 1sg9B-6b92A:
16.7		 1sg9B-6b92A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Legionella
pneumophila) 		no annotation 5 THR A 121
ILE A 164
GLY A 153
ILE A 134
VAL A 196
 None
 1.03A 1sg9B-6cktA:
undetectable		 1sg9B-6cktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpy PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		3 ASP A  94
PHE A  89
ASN A  64
 None
 0.88A 1sg9B-1dpyA:
undetectable		 1sg9B-1dpyA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 ASP C 320
PHE C 191
ASN C 187
 None
 0.80A 1sg9B-1ea9C:
undetectable		 1sg9B-1ea9C:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 3 ASP B1252
PHE B 451
ASN B1237
 None
 0.76A 1sg9B-1ej6B:
2.0		 1sg9B-1ej6B:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		3 ASP A 250
PHE A 117
ASN A 167
 None
 0.65A 1sg9B-1h7wA:
3.8		 1sg9B-1h7wA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH

(Thermus
thermophilus) 		PF00004
(AAA) 		3 ASP A 287
PHE A 241
ASN A 280
 None
 0.68A 1sg9B-1iy1A:
undetectable		 1sg9B-1iy1A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH

(Thermus
thermophilus) 		PF00004
(AAA) 		3 ASP A 287
PHE A 241
ASN A 280
 None
 0.61A 1sg9B-1iy2A:
undetectable		 1sg9B-1iy2A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv7 FTSH

(Escherichia
coli) 		PF00004
(AAA) 		3 ASP A 286
PHE A 240
ASN A 279
 None
 0.73A 1sg9B-1lv7A:
3.1		 1sg9B-1lv7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyq THREONYL-TRNA
SYNTHETASE 1

(Staphylococcus
aureus) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		3 ASP A 452
PHE A 399
ASN A 445
 None
 0.68A 1sg9B-1nyqA:
undetectable		 1sg9B-1nyqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE

(Salmonella
enterica) 		PF00583
(Acetyltransf_1) 		3 ASP A 115
PHE A 132
ASN A 120
 None
None
COA  A 600 ( 3.2A)
 0.88A 1sg9B-1s5kA:
undetectable		 1sg9B-1s5kA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		3 ASP A 151
PHE A 180
ASN A 197
 SAM  A 301 (-2.9A)
SAM  A 301 (-3.5A)
GLN  A 400 ( 3.1A)
 0.10A 1sg9B-1sg9A:
43.8		 1sg9B-1sg9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te7 HYPOTHETICAL UPF0267
PROTEIN YQFB

(Escherichia
coli) 		PF04266
(ASCH) 		3 ASP A  15
PHE A   9
ASN A  75
 None
 0.89A 1sg9B-1te7A:
undetectable		 1sg9B-1te7A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE

(Populus tremula) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		3 ASP A 269
PHE A 141
ASN A 153
 None
 0.84A 1sg9B-1un1A:
undetectable		 1sg9B-1un1A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		3 ASP A  66
PHE A  83
ASN A  62
 None
 0.51A 1sg9B-1w6jA:
undetectable		 1sg9B-1w6jA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5p NEGATIVE ELONGATION
FACTOR E

(Homo sapiens) 		PF00076
(RRM_1) 		3 ASP A  63
PHE A  37
ASN A  82
 None
 0.68A 1sg9B-1x5pA:
undetectable		 1sg9B-1x5pA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtp LMAJ004091AAA

(Leishmania
major) 		PF05891
(Methyltransf_PK) 		3 ASP A  99
PHE A 194
ASN A 110
 None
 0.73A 1sg9B-1xtpA:
9.9		 1sg9B-1xtpA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 ASP A1403
PHE A1490
ASN A1438
 None
 0.85A 1sg9B-2b39A:
undetectable		 1sg9B-2b39A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		3 ASP A 385
PHE A 356
ASN A 378
 None
 0.80A 1sg9B-2b3bA:
undetectable		 1sg9B-2b3bA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhr FTSH

(Thermus
thermophilus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		3 ASP A 287
PHE A 241
ASN A 280
 None
 0.62A 1sg9B-2dhrA:
undetectable		 1sg9B-2dhrA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e30 CALCIUM-BINDING
PROTEIN P22

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 ASP A  39
PHE A  35
ASN A  79
 None
 0.82A 1sg9B-2e30A:
2.3		 1sg9B-2e30A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5a LIPOYLTRANSFERASE 1

(Bos taurus) 		no annotation 3 ASP A 275
PHE A 310
ASN A 302
 None
 0.85A 1sg9B-2e5aA:
2.1		 1sg9B-2e5aA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ASP A 211
PHE A 169
ASN A 165
 None
 0.49A 1sg9B-2e7zA:
undetectable		 1sg9B-2e7zA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is3 RIBONUCLEASE T

(Escherichia
coli) 		PF00929
(RNase_T) 		3 ASP A  23
PHE A 128
ASN A 121
 None
 0.64A 1sg9B-2is3A:
undetectable		 1sg9B-2is3A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jau 5'(3')-DEOXYRIBONUCL
EOTIDASE

(Homo sapiens) 		PF06941
(NT5C) 		3 ASP A 171
PHE A 127
ASN A 123
 None
 0.55A 1sg9B-2jauA:
undetectable		 1sg9B-2jauA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ASP A 218
PHE A 173
ASN A 200
 None
 0.80A 1sg9B-2nyaA:
undetectable		 1sg9B-2nyaA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE

(Agrobacterium
fabrum) 		PF03562
(MltA)
PF06725
(3D) 		3 ASP A  22
PHE A  77
ASN A  68
 None
 0.80A 1sg9B-2pnwA:
undetectable		 1sg9B-2pnwA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz4 PARAPLEGIN

(Homo sapiens) 		PF00004
(AAA) 		3 ASP A 441
PHE A 394
ASN A 434
 None
 0.75A 1sg9B-2qz4A:
3.4		 1sg9B-2qz4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 ASP A 233
PHE A 192
ASN A 188
 None
 0.67A 1sg9B-2r3sA:
13.4		 1sg9B-2r3sA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5k MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
10) 		PF00500
(Late_protein_L1) 		3 ASP A 237
PHE A 244
ASN A 391
 None
 0.71A 1sg9B-2r5kA:
undetectable		 1sg9B-2r5kA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		3 ASP A 295
PHE A 300
ASN A 287
 None
 0.72A 1sg9B-2vg8A:
2.0		 1sg9B-2vg8A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE

(Homo sapiens) 		PF00004
(AAA) 		3 ASP A 710
PHE A 667
ASN A 703
 None
 0.83A 1sg9B-2x8aA:
undetectable		 1sg9B-2x8aA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		3 ASP A 490
PHE A 449
ASN A 483
 None
 0.80A 1sg9B-2xdfA:
undetectable		 1sg9B-2xdfA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		3 ASP A 326
PHE A 321
ASN A 255
 None
 0.88A 1sg9B-3au9A:
2.5		 1sg9B-3au9A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana) 		PF03492
(Methyltransf_7) 		3 ASP A 235
PHE A 365
ASN A 361
 None
 0.75A 1sg9B-3b5iA:
7.4		 1sg9B-3b5iA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ASP A  77
PHE A 120
ASN A  68
 None
 0.66A 1sg9B-3eykA:
undetectable		 1sg9B-3eykA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB

(Escherichia
coli) 		PF04449
(Fimbrial_CS1)
PF07434
(CblD) 		3 ASP A 241
PHE A 167
ASN A 197
 None
 0.76A 1sg9B-3f83A:
undetectable		 1sg9B-3f83A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Clostridium
acetobutylicum) 		PF00155
(Aminotran_1_2) 		3 ASP A 183
PHE A 208
ASN A 114
 None
 0.70A 1sg9B-3ftbA:
4.4		 1sg9B-3ftbA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbk PUTATIVE GLYCOSYL
HYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		3 ASP A 101
PHE A  74
ASN A  98
 None
 0.79A 1sg9B-3hbkA:
undetectable		 1sg9B-3hbkA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwg ACETYLTRANSFERASE,
GNAT FAMILY

(Colwellia
psychrerythraea) 		PF00583
(Acetyltransf_1) 		3 ASP A 112
PHE A 268
ASN A 105
 None
 0.75A 1sg9B-3iwgA:
undetectable		 1sg9B-3iwgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 3 ASP A 321
PHE A 131
ASN A 123
 None
 0.81A 1sg9B-3j4uA:
undetectable		 1sg9B-3j4uA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcx FAB E LIGHT CHAIN

(Rattus
norvegicus) 		PF07686
(V-set) 		3 ASP L  32
PHE L  71
ASN L  51
 None
 0.89A 1sg9B-3jcxL:
undetectable		 1sg9B-3jcxL:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		3 ASP E 292
PHE E 246
ASN E 285
 None
 0.67A 1sg9B-3kdsE:
undetectable		 1sg9B-3kdsE:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc1 PREDICTED
PHOSPHATASE, HAD
FAMILY

(Clostridium
acetobutylicum) 		PF13419
(HAD_2) 		3 ASP A 128
PHE A   7
ASN A   3
 None
 0.64A 1sg9B-3mc1A:
undetectable		 1sg9B-3mc1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN
CAPSID PROTEIN

(Triatoma virus;
Triatoma virus) 		PF08762
(CRPV_capsid)
PF00073
(Rhv) 		3 ASP A  10
PHE C 125
ASN C  64
 None
 0.68A 1sg9B-3napA:
undetectable		 1sg9B-3napA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ofl L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		3 ASP A 240
PHE A 247
ASN A 396
 None
 0.85A 1sg9B-3oflA:
undetectable		 1sg9B-3oflA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvd CAPSID

(Norwalk virus) 		PF08435
(Calici_coat_C) 		3 ASP A 247
PHE A 242
ASN A 443
 None
 0.83A 1sg9B-3pvdA:
undetectable		 1sg9B-3pvdA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgc POSSIBLE PERIPLASMIC
PROTEIN

(Campylobacter
jejuni) 		PF09312
(SurA_N) 		3 ASP A 136
PHE A 143
ASN A 243
 None
 0.73A 1sg9B-3rgcA:
undetectable		 1sg9B-3rgcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy8 ROCR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00563
(EAL) 		3 ASP A 146
PHE A 193
ASN A 153
 None
 0.80A 1sg9B-3sy8A:
undetectable		 1sg9B-3sy8A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacteroides
abscessus) 		PF01182
(Glucosamine_iso) 		3 ASP A 142
PHE A  69
ASN A  65
 None
None
NA  A 248 (-3.4A)
 0.62A 1sg9B-3tx2A:
undetectable		 1sg9B-3tx2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF00180
(Iso_dh) 		3 ASP A  68
PHE A 101
ASN A  40
 None
 0.84A 1sg9B-3uduA:
2.1		 1sg9B-3uduA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		3 ASP A 502
PHE A 499
ASN A 510
 ANP  A2001 (-2.9A)
None
None
 0.79A 1sg9B-3ummA:
undetectable		 1sg9B-3ummA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 ASP A 155
PHE A 128
ASN A 119
 None
 0.88A 1sg9B-3wy2A:
undetectable		 1sg9B-3wy2A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		3 ASP A 258
PHE A 225
ASN A 233
 None
VNL  A 401 ( 4.8A)
None
 0.87A 1sg9B-4eygA:
3.4		 1sg9B-4eygA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr2 1,3-PROPANEDIOL
DEHYDROGENASE

(Oenococcus oeni) 		PF00465
(Fe-ADH) 		3 ASP A 378
PHE A 383
ASN A 296
 None
 0.77A 1sg9B-4fr2A:
3.2		 1sg9B-4fr2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfu FAB 8M2 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASP H  65
PHE H  63
ASN H  82
 None
 0.72A 1sg9B-4hfuH:
undetectable		 1sg9B-4hfuH:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN

(Bacteroides
ovatus) 		PF01833
(TIG) 		3 ASP A 452
PHE A 170
ASN A 154
 None
 0.88A 1sg9B-4hw6A:
undetectable		 1sg9B-4hw6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4j ACP-POLYENE
THIOESTERASE

(Streptomyces
globisporus) 		PF13279
(4HBT_2) 		3 ASP A  77
PHE A  17
ASN A  25
 None
 0.68A 1sg9B-4i4jA:
undetectable		 1sg9B-4i4jA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN

(Streptococcus
gordonii) 		no annotation 3 ASP D 198
PHE D 234
ASN D 238
 None
 0.84A 1sg9B-4igbD:
undetectable		 1sg9B-4igbD:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg2 PHAGE-RELATED
PROTEIN

(Bacillus cereus) 		PF10991
(DUF2815) 		3 ASP A  57
PHE A 135
ASN A  50
 None
 0.76A 1sg9B-4jg2A:
undetectable		 1sg9B-4jg2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		3 ASP A 590
PHE A 595
ASN A 487
 None
 0.85A 1sg9B-4ktpA:
undetectable		 1sg9B-4ktpA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcb CELL DIVISION
PROTEIN CDVC, VPS4

(Acidianus
hospitalis) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 ASP A 227
PHE A 180
ASN A 220
 None
 0.75A 1sg9B-4lcbA:
undetectable		 1sg9B-4lcbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgm VPS4 AAA ATPASE

(Sulfolobus
solfataricus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 ASP A 233
PHE A 186
ASN A 226
 None
 0.73A 1sg9B-4lgmA:
2.6		 1sg9B-4lgmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nyn RIBONUCLEASE HI

(Halobacterium
salinarum) 		PF13456
(RVT_3) 		3 ASP A 117
PHE A  74
ASN A 111
 None
 0.66A 1sg9B-4nynA:
undetectable		 1sg9B-4nynA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3f SPLICEOSOMAL PROTEIN
CWC27

(Chaetomium
thermophilum) 		PF00160
(Pro_isomerase) 		3 ASP A 110
PHE A 156
ASN A 107
 None
 0.87A 1sg9B-4r3fA:
undetectable		 1sg9B-4r3fA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Aliivibrio
fischeri) 		PF00092
(VWA) 		3 ASP A  70
PHE A  68
ASN A  95
 None
 0.79A 1sg9B-4rckA:
undetectable		 1sg9B-4rckA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		3 ASP A 255
PHE A 418
ASN A 345
 None
None
NAG  A 808 (-1.8A)
 0.80A 1sg9B-4tweA:
2.2		 1sg9B-4tweA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8y MEMBRANE-ASSOCIATED
PROGESTERONE
RECEPTOR COMPONENT 1

(Homo sapiens) 		PF00173
(Cyt-b5) 		3 ASP A 140
PHE A 116
ASN A  94
 None
 0.87A 1sg9B-4x8yA:
undetectable		 1sg9B-4x8yA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B

(Anopheles
gambiae) 		PF13855
(LRR_8) 		3 ASP A 300
PHE A 307
ASN A 279
 None
 0.87A 1sg9B-4xgoA:
undetectable		 1sg9B-4xgoA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		3 ASP A 326
PHE A 321
ASN A 255
 None
 0.84A 1sg9B-4y67A:
4.0		 1sg9B-4y67A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH

(Aquifex
aeolicus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		3 ASP A 287
PHE A 240
ASN A 280
 None
 0.86A 1sg9B-4z8xA:
undetectable		 1sg9B-4z8xA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		3 ASP A 252
PHE A 183
ASN A 223
 None
 0.88A 1sg9B-4zxoA:
undetectable		 1sg9B-4zxoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3m CEA1

(Komagataella
pastoris) 		PF10528
(GLEYA) 		3 ASP A 137
PHE A  67
ASN A  57
 NAG  A 501 ( 2.5A)
None
None
 0.88A 1sg9B-5a3mA:
undetectable		 1sg9B-5a3mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8h TYPE III
PANTOTHENATE KINASE

(Burkholderia
cenocepacia) 		PF03309
(Pan_kinase) 		3 ASP A  37
PHE A  32
ASN A  12
 None
None
PAU  A 302 (-4.6A)
 0.76A 1sg9B-5b8hA:
undetectable		 1sg9B-5b8hA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb7 OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		no annotation 3 ASP A 100
PHE A 103
ASN A 172
 None
 0.77A 1sg9B-5cb7A:
undetectable		 1sg9B-5cb7A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 3 ASP B 286
PHE B 508
ASN B 306
 None
 0.86A 1sg9B-5do8B:
undetectable		 1sg9B-5do8B:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb0 NUCLEOPORIN NUP170
NUCLEOPORIN NUP145

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		no annotation
no annotation 		3 ASP B1159
PHE B1176
ASN E 736
 None
 0.81A 1sg9B-5hb0B:
undetectable		 1sg9B-5hb0B:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase)
PF00515
(TPR_1) 		3 ASP A 117
PHE A 161
ASN A 114
 None
 0.86A 1sg9B-5jheA:
undetectable		 1sg9B-5jheA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		3 ASP A 937
PHE A 870
ASN A 930
 None
 0.73A 1sg9B-5mzaA:
undetectable		 1sg9B-5mzaA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 ASP A 353
PHE A 581
ASN A   2
 None
 0.75A 1sg9B-5neuA:
undetectable		 1sg9B-5neuA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 3 ASP A 367
PHE A 418
ASN A 241
 None
 0.68A 1sg9B-5oltA:
undetectable		 1sg9B-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5omc REPLICATION FACTOR A
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A  10
PHE A  15
ASN A  23
 None
 0.88A 1sg9B-5omcA:
undetectable		 1sg9B-5omcA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ore OCTOPINE-BINDING
PERIPLASMIC PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 3 ASP A 197
PHE A 113
ASN A 152
 None
 0.88A 1sg9B-5oreA:
undetectable		 1sg9B-5oreA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syt CAAX PRENYL PROTEASE
1 HOMOLOG

(Homo sapiens) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		3 ASP A 281
PHE A 226
ASN A 265
 DMS  A 521 ( 4.9A)
None
None
 0.73A 1sg9B-5sytA:
undetectable		 1sg9B-5sytA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 3 ASP A 179
PHE A 161
ASN A 172
 None
 0.76A 1sg9B-5tizA:
undetectable		 1sg9B-5tizA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuk TETRACYCLINE
DESTRUCTASE TET(51)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		3 ASP A 289
PHE A 271
ASN A 341
 FAD  A 402 (-3.0A)
None
None
 0.78A 1sg9B-5tukA:
undetectable		 1sg9B-5tukA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubv ATPASE DOMAIN OF
I-AAA PROTEASE

(Thermothelomyces
thermophila) 		no annotation 3 ASP A 134
PHE A  91
ASN A 127
 None
 0.71A 1sg9B-5ubvA:
2.1		 1sg9B-5ubvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 ASP A 208
PHE A 254
ASN A 178
 None
 0.73A 1sg9B-5um6A:
5.8		 1sg9B-5um6A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 ASP A 489
PHE A 484
ASN A 440
 None
LA6  A 704 (-4.6A)
None
 0.86A 1sg9B-5uv2A:
undetectable		 1sg9B-5uv2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 3 ASP A 285
PHE A 233
ASN A 278
 None
 0.81A 1sg9B-5wc2A:
undetectable		 1sg9B-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 3 ASP A 164
PHE A 639
ASN A 215
 None
 0.83A 1sg9B-5x3jA:
undetectable		 1sg9B-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xl6 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ASP A  73
PHE A 116
ASN A  64
 None
 0.71A 1sg9B-5xl6A:
undetectable		 1sg9B-5xl6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A 196
PHE A 224
ASN A 121
 None
 0.82A 1sg9B-5xzwA:
undetectable		 1sg9B-5xzwA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu5 ALGINATE LYASE

(Vibrio
splendidus) 		no annotation 3 ASP A  77
PHE A 106
ASN A 130
 None
 0.84A 1sg9B-5zu5A:
undetectable		 1sg9B-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu6 CBM32 DOMAIN

(Vibrio) 		no annotation 3 ASP A  77
PHE A 106
ASN A 130
 None
 0.85A 1sg9B-5zu6A:
undetectable		 1sg9B-5zu6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A 409
PHE A 366
ASN A 402
 None
 0.68A 1sg9B-6az0A:
2.5		 1sg9B-6az0A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2w PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN

(Campylobacter
jejuni) 		no annotation 3 ASP A 197
PHE A 190
ASN A 310
 None
 0.80A 1sg9B-6b2wA:
undetectable		 1sg9B-6b2wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE

(Escherichia
coli) 		no annotation 3 ASP A 135
PHE A 152
ASN A 140
 MG  A 201 (-2.7A)
None
None
 0.87A 1sg9B-6bffA:
undetectable		 1sg9B-6bffA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c80 CYTOKININ OXIDASE
LUCKX1.1

(Linum
usitatissimum) 		no annotation 3 ASP A 355
PHE A 361
ASN A 301
 None
 0.76A 1sg9B-6c80A:
undetectable		 1sg9B-6c80A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 ASP H 626
PHE H 580
ASN H 619
 None
 0.78A 1sg9B-6chsH:
3.4		 1sg9B-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cqb CHALCONE SYNTHASE

(Piper
methysticum) 		no annotation 3 ASP A  83
PHE A 199
ASN A  80
 None
 0.83A 1sg9B-6cqbA:
undetectable		 1sg9B-6cqbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g96 ACETYLTRANSFERASE

(Salmonella
enterica) 		no annotation 3 ASP B  98
PHE B  61
ASN B  16
 None
 0.82A 1sg9B-6g96B:
undetectable		 1sg9B-6g96B:
undetectable