SIMILAR PATTERNS OF AMINO ACIDS FOR 1SG9_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dus MJ0882

(Methanocaldococcus
jannaschii) 		PF05175
(MTS) 		5 PHE A  35
GLY A  65
ILE A  69
ASN A 129
PRO A 131
 None
 0.46A 1sg9A-1dusA:
18.9		 1sg9A-1dusA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1
ECHOVIRUS 1

(Enterovirus B;
Enterovirus B) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 PRO 1  44
GLY 3 113
ILE 3 169
VAL 3 223
SER 3 222
 None
 1.17A 1sg9A-1ev11:
undetectable		 1sg9A-1ev11:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ILE A 180
GLY A 586
VAL A  22
SER A  21
ASN A 177
 None
None
SF4  A1010 ( 4.3A)
None
None
 1.10A 1sg9A-1h0hA:
undetectable		 1sg9A-1h0hA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1irx LYSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01921
(tRNA-synt_1f) 		5 PHE A  39
ILE A 273
GLY A  37
ILE A 315
VAL A 287
 None
 1.16A 1sg9A-1irxA:
undetectable		 1sg9A-1irxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrk UDP-GLUCOSE
4-EPIMERASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A  12
GLY A   8
ILE A  78
SER A  36
GLU A 191
 NAD  A 340 (-3.9A)
None
None
NAD  A 340 (-2.7A)
None
 1.23A 1sg9A-1lrkA:
5.8		 1sg9A-1lrkA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN
POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B;
Enterovirus B) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 PRO A  44
GLY C 112
ILE C 168
VAL C 222
SER C 221
 None
 1.25A 1sg9A-1mqtA:
undetectable		 1sg9A-1mqtA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		5 PHE A 659
ILE A 643
GLY A 661
THR A 773
GLU A 771
 None
 1.17A 1sg9A-1nd7A:
undetectable		 1sg9A-1nd7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 ILE A  92
GLY A  95
ILE A 155
VAL A 117
SER A 118
 None
SAM  A1401 (-3.4A)
SAM  A1401 (-4.2A)
None
None
 1.19A 1sg9A-1p91A:
10.4		 1sg9A-1p91A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		5 ILE A  57
GLY A  27
ILE A  35
VAL A 116
ASN A  34
 None
 1.20A 1sg9A-1pe9A:
undetectable		 1sg9A-1pe9A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		5 PRO A  59
GLY A 137
ILE A 130
VAL A 218
PHE A 215
 None
 1.20A 1sg9A-1ru3A:
3.7		 1sg9A-1ru3A:
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		6 PHE A 100
PRO A 102
GLY A 131
THR A 150
PHE A 180
PRO A 198
 SAM  A 301 ( 3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 ( 3.8A)
None
SAM  A 301 (-3.5A)
GLN  A 400 (-4.9A)
 1.45A 1sg9A-1sg9A:
46.2		 1sg9A-1sg9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		12 PHE A 100
PRO A 102
ILE A 128
GLY A 131
ILE A 135
THR A 150
VAL A 152
SER A 153
GLU A 179
PHE A 180
ASN A 197
PRO A 199
 SAM  A 301 ( 3.4A)
SAM  A 301 (-3.6A)
None
SAM  A 301 ( 3.8A)
SAM  A 301 (-4.8A)
None
SAM  A 301 (-4.3A)
None
None
SAM  A 301 (-3.5A)
GLN  A 400 ( 3.1A)
SAM  A 301 ( 4.6A)
 0.05A 1sg9A-1sg9A:
46.2		 1sg9A-1sg9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfurisphaera
tokodaii) 		PF01048
(PNP_UDP_1) 		5 ILE A  77
VAL A  91
SER A  92
ASN A  76
PRO A  58
 None
 1.25A 1sg9A-1v4nA:
undetectable		 1sg9A-1v4nA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 425
ILE A 411
VAL A 362
SER A 361
GLU A 368
 None
 1.17A 1sg9A-1v59A:
3.3		 1sg9A-1v59A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x57 ENDOTHELIAL
DIFFERENTIATION-RELA
TED FACTOR 1

(Homo sapiens) 		PF01381
(HTH_3) 		5 ILE A  18
GLY A  59
ILE A  36
GLU A  13
PRO A  53
 None
 1.09A 1sg9A-1x57A:
undetectable		 1sg9A-1x57A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5t SPLICING FACTOR 3B
SUBUNIT 4

(Homo sapiens) 		PF00076
(RRM_1) 		5 ILE A  53
GLY A  11
ILE A  38
VAL A  80
PHE A  55
 None
 1.19A 1sg9A-1x5tA:
undetectable		 1sg9A-1x5tA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdq BACTERIAL SULFITE
OXIDASE

(Escherichia
coli) 		PF00174
(Oxidored_molyb) 		5 ILE A 196
GLY A 190
ILE A 206
THR A 177
VAL A 180
 None
 1.15A 1sg9A-1xdqA:
undetectable		 1sg9A-1xdqA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 PHE A 195
PRO A 197
ILE A 159
GLY A 162
ILE A  45
 None
 1.18A 1sg9A-1zb7A:
undetectable		 1sg9A-1zb7A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuw GLUTAMATE RACEMASE 1

(Bacillus
subtilis) 		PF01177
(Asp_Glu_race) 		5 GLY A 117
THR A 186
VAL A 149
GLU A 153
PRO A  44
 None
DGL  A1301 (-3.1A)
None
None
None
 1.25A 1sg9A-1zuwA:
2.3		 1sg9A-1zuwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 PRO A  91
GLY A 119
ILE A 123
ASN A 183
PRO A 185
 SAH  A 300 (-4.0A)
SAH  A 300 (-3.5A)
None
SAH  A 300 (-3.9A)
SAH  A 300 ( 3.9A)
 0.61A 1sg9A-2b3tA:
29.0		 1sg9A-2b3tA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4w HYPOTHETICAL
PROTEIN, CONSERVED

(Leishmania
major) 		PF08950
(DUF1861) 		5 PHE A 265
ILE A  45
GLY A 282
VAL A  30
PRO A  84
 None
 1.17A 1sg9A-2b4wA:
undetectable		 1sg9A-2b4wA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehr INAD-LIKE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  75
GLY A  36
VAL A  92
SER A  89
PHE A 104
 None
 1.26A 1sg9A-2ehrA:
undetectable		 1sg9A-2ehrA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6t UNCHARACTERIZED
PROTEIN, HOMOLOG
HI1244 FROM
HAEMOPHILUS
INFLUENZAE

(Clostridium
acetobutylicum) 		PF08942
(DUF1919) 		5 ILE A 112
GLY A 129
ILE A 108
VAL A 124
PHE A 216
 None
 1.16A 1sg9A-2g6tA:
2.5		 1sg9A-2g6tA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn1 THREONINE
DEHYDRATASE
CATABOLIC

(Salmonella
enterica) 		PF00291
(PALP) 		5 PHE A  57
GLY A  61
ILE A 159
VAL A  90
PHE A 149
 LLP  A  58 ( 3.8A)
LLP  A  58 ( 4.2A)
None
None
None
 1.24A 1sg9A-2gn1A:
3.4		 1sg9A-2gn1A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzm GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		5 GLY A 117
THR A 186
VAL A 149
GLU A 153
PRO A  45
 None
DGL  A 501 (-3.0A)
None
None
None
 1.22A 1sg9A-2gzmA:
4.0		 1sg9A-2gzmA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN

(Homo sapiens) 		PF05971
(Methyltransf_10) 		7 PRO A  40
ILE A  72
GLY A  75
THR A  95
VAL A  97
ASN A 147
PRO A 149
 SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.6A)
SAH  A 300 (-4.3A)
SAH  A 300 (-4.2A)
SAH  A 300 (-3.9A)
SAH  A 300 (-4.0A)
 0.53A 1sg9A-2h00A:
17.7		 1sg9A-2h00A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		5 PHE A  62
ILE A 119
ILE A 112
SER A 345
PHE A 123
 None
 1.20A 1sg9A-2i3oA:
undetectable		 1sg9A-2i3oA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		5 GLY A 115
THR A 185
VAL A 147
GLU A 151
PRO A  43
 None
DGL  A1267 (-2.8A)
None
None
None
 1.20A 1sg9A-2jfqA:
3.6		 1sg9A-2jfqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A 208
GLY A 205
ILE A 434
SER A 166
GLU A 163
 None
 1.20A 1sg9A-2nlxA:
undetectable		 1sg9A-2nlxA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnm PROTEASE VP4

(Infectious
pancreatic
necrosis virus) 		PF01768
(Birna_VP4) 		5 PRO A 544
ILE A 706
GLY A 637
ILE A 686
GLU A 646
 None
 1.13A 1sg9A-2pnmA:
undetectable		 1sg9A-2pnmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7v THIOREDOXIN
REDUCTASE

(Deinococcus
radiodurans) 		PF07992
(Pyr_redox_2) 		5 PHE A 244
ILE A 206
GLY A 159
THR A 209
VAL A 211
 None
 1.14A 1sg9A-2q7vA:
3.9		 1sg9A-2q7vA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r79 PERIPLASMIC BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF01497
(Peripla_BP_2) 		5 GLY A  35
THR A  55
VAL A  53
SER A  32
PRO A  60
 None
None
None
None
GOL  A 880 (-4.3A)
 1.19A 1sg9A-2r79A:
undetectable		 1sg9A-2r79A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray Valley
encephalitis
virus) 		PF00271
(Helicase_C)
PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B)
PF07652
(Flavi_DEAD) 		5 ILE A 424
GLY A 476
VAL A 336
SER A 337
GLU A 472
 None
 1.26A 1sg9A-2wv9A:
2.3		 1sg9A-2wv9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xb3 PSBP PROTEIN

(Thermosynechococcus
elongatus) 		PF01789
(PsbP) 		5 GLY A  90
ILE A  97
SER A  85
GLU A  82
ASN A  96
 None
 1.08A 1sg9A-2xb3A:
undetectable		 1sg9A-2xb3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A

(Sulfolobus
shibatae) 		PF04406
(TP6A_N) 		5 PRO A 379
ILE A 258
THR A 260
SER A 298
PHE A 270
 None
 1.04A 1sg9A-2zbkA:
undetectable		 1sg9A-2zbkA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg1 PROTEIN SEC13
HOMOLOG

(Homo sapiens) 		PF00400
(WD40) 		5 ILE A 129
GLY A 152
VAL A 106
SER A 105
ASN A 147
 None
 1.16A 1sg9A-3bg1A:
undetectable		 1sg9A-3bg1A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		5 ILE A  83
GLY A  42
ILE A  92
VAL A  47
ASN A  91
 None
R1P  A 401 (-3.2A)
None
None
None
 1.23A 1sg9A-3bjeA:
undetectable		 1sg9A-3bjeA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5i CHOLINE KINASE

(Plasmodium
knowlesi) 		PF01633
(Choline_kinase) 		5 ILE A 123
VAL A 261
SER A 262
GLU A 268
ASN A 222
 None
None
None
None
MG  A 370 ( 4.4A)
 1.23A 1sg9A-3c5iA:
undetectable		 1sg9A-3c5iA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clh 3-DEHYDROQUINATE
SYNTHASE

(Helicobacter
pylori) 		PF01761
(DHQ_synthase) 		5 ILE A 254
GLY A 230
GLU A 250
PHE A 288
ASN A 260
 None
 1.13A 1sg9A-3clhA:
undetectable		 1sg9A-3clhA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n DIHYDROOROTASE

(Aquifex
aeolicus) 		PF01979
(Amidohydro_1) 		5 PHE A  87
ILE A 354
GLY A  56
ILE A 349
THR A 366
 None
 0.98A 1sg9A-3d6nA:
undetectable		 1sg9A-3d6nA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ea0 ATPASE, PARA FAMILY

(Chlorobaculum
tepidum) 		PF13614
(AAA_31) 		5 ILE A 120
GLY A  15
GLU A 140
PHE A   4
ASN A  21
 None
ATP  A 243 (-3.8A)
None
None
None
 1.21A 1sg9A-3ea0A:
3.1		 1sg9A-3ea0A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		5 ILE A  87
GLY A  90
THR A 110
VAL A 112
PRO A 157
 None
 0.49A 1sg9A-3evzA:
18.3		 1sg9A-3evzA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsc QDTC

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00132
(Hexapep) 		5 PRO A 161
ILE A 173
GLY A 170
ILE A 189
VAL A 125
 None
 1.07A 1sg9A-3fscA:
undetectable		 1sg9A-3fscA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3e UNCHARACTERIZED
PROTEIN TM1679

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		5 PRO A 222
ILE A 180
ILE A 173
GLU A 186
PHE A 184
 None
 1.14A 1sg9A-3h3eA:
undetectable		 1sg9A-3h3eA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		5 PRO A 297
ILE A 242
GLY A 247
ILE A 245
ASN A 244
 None
LLP  A 243 ( 4.3A)
None
None
LLP  A 243 ( 4.7A)
 1.10A 1sg9A-3hvyA:
4.6		 1sg9A-3hvyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i16 ALUMINUM RESISTANCE
PROTEIN

(Clostridium
novyi) 		PF06838
(Met_gamma_lyase) 		5 PRO A 297
ILE A 242
GLY A 247
ILE A 245
ASN A 244
 None
 1.09A 1sg9A-3i16A:
4.1		 1sg9A-3i16A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ics COENZYME A-DISULFIDE
REDUCTASE

(Bacillus
anthracis) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 382
THR A 395
VAL A 340
ASN A 346
PRO A 191
 None
 1.21A 1sg9A-3icsA:
3.6		 1sg9A-3icsA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihj ALANINE
AMINOTRANSFERASE 2

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 PRO A 377
ILE A 387
GLY A 351
ILE A 159
SER A 340
 None
None
None
None
PLP  A   1 ( 4.1A)
 0.91A 1sg9A-3ihjA:
3.7		 1sg9A-3ihjA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ILE A  99
GLY A 115
GLU A  92
PHE A  18
ASN A  73
 None
 1.22A 1sg9A-3k92A:
2.7		 1sg9A-3k92A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd9 COENZYME A DISULFIDE
REDUCTASE

(Pyrococcus
horikoshii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 279
THR A 284
VAL A 295
ASN A 302
PRO A 299
 None
 1.18A 1sg9A-3kd9A:
3.0		 1sg9A-3kd9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8d METHYLTRANSFERASE

(Bacillus
thuringiensis) 		PF08241
(Methyltransf_11) 		5 GLY A  67
ILE A 123
SER A  72
GLU A  56
PHE A 117
 None
 1.18A 1sg9A-3l8dA:
10.9		 1sg9A-3l8dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		5 ILE A 371
GLY A 500
ILE A 350
VAL A 464
PHE A 380
 None
 1.14A 1sg9A-3lfvA:
undetectable		 1sg9A-3lfvA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC

(Escherichia
coli) 		no annotation 5 ILE A 201
ILE A 221
SER A 449
ASN A 244
PRO A 481
 None
 1.22A 1sg9A-3ly9A:
undetectable		 1sg9A-3ly9A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 185
GLY A   8
ILE A  85
VAL A   5
GLU A 243
 None
 1.09A 1sg9A-3oytA:
undetectable		 1sg9A-3oytA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6d PROLINE DIPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ILE A 228
GLY A 188
ILE A 203
VAL A 327
PRO A 233
 None
 1.13A 1sg9A-3q6dA:
undetectable		 1sg9A-3q6dA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q87 N6 ADENINE SPECIFIC
DNA METHYLASE

(Encephalitozoon
cuniculi) 		PF05175
(MTS) 		5 PRO B   6
ILE B  37
THR B  50
ASN B  85
PRO B  87
 SAM  B 300 ( 4.5A)
None
None
SAM  B 300 (-3.9A)
SAM  B 300 (-4.1A)
 0.50A 1sg9A-3q87B:
18.2		 1sg9A-3q87B:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		5 PRO A 671
ILE A 588
ILE A 667
THR A 589
PHE A 587
 None
 1.24A 1sg9A-3wfzA:
undetectable		 1sg9A-3wfzA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		5 PRO A 326
ILE A 277
GLY A 305
THR A 299
PHE A 435
 None
 1.23A 1sg9A-3x3yA:
undetectable		 1sg9A-3x3yA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdr ALCOHOL
DEHYDROGENASE DOMAIN
OF THE BIFUNCTIONAL
ACETALDEHYDE
DEHYDROGENASE

(Parageobacillus
thermoglucosidasius) 		PF00465
(Fe-ADH) 		5 PHE A 721
ILE A 687
ILE A 716
VAL A 671
SER A 672
 GOL  A1872 (-4.2A)
None
None
None
None
 1.11A 1sg9A-3zdrA:
undetectable		 1sg9A-3zdrA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 PHE A 443
PRO A 543
ILE A 509
THR A 508
VAL A 503
 None
 1.18A 1sg9A-4bedA:
undetectable		 1sg9A-4bedA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bk1 PROBABLE SALICYLATE
MONOOXYGENASE

(Rhodococcus
jostii) 		PF01494
(FAD_binding_3) 		5 ILE A 158
GLY A 161
ILE A  11
VAL A 285
ASN A  21
 None
 1.04A 1sg9A-4bk1A:
undetectable		 1sg9A-4bk1A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
PF17243
(POTRA_TamA_1) 		5 PRO A 464
ILE A 484
GLY A 495
VAL A 526
SER A 527
 None
 0.97A 1sg9A-4c00A:
undetectable		 1sg9A-4c00A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		6 PHE A 208
GLY A 238
ILE A 242
SER A 261
ASN A 305
PRO A 307
 SAM  A 401 (-3.6A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-4.7A)
None
SAM  A 401 (-3.8A)
SAM  A 401 (-4.0A)
 0.55A 1sg9A-4dcmA:
17.3		 1sg9A-4dcmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyv SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF00106
(adh_short) 		5 ILE A  32
GLY A  59
VAL A  89
GLU A 144
ASN A 109
 None
 1.18A 1sg9A-4dyvA:
7.1		 1sg9A-4dyvA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esj TYPE-2 RESTRICTION
ENZYME DPNI

(Streptococcus
pneumoniae) 		PF06044
(DpnI) 		5 ILE A 143
GLY A 140
ILE A 124
GLU A  64
PHE A  96
 None
 1.25A 1sg9A-4esjA:
undetectable		 1sg9A-4esjA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fle ESTERASE

(Yersinia
enterocolitica) 		PF05728
(UPF0227) 		5 ILE A   8
ILE A  38
SER A  54
PHE A  75
PRO A  42
 None
 0.92A 1sg9A-4fleA:
undetectable		 1sg9A-4fleA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ija XYLR PROTEIN

(Staphylococcus
aureus) 		PF00480
(ROK)
PF01047
(MarR) 		5 ILE A 166
GLY A 134
ILE A 122
VAL A 175
ASN A 171
 None
 1.23A 1sg9A-4ijaA:
undetectable		 1sg9A-4ijaA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A  63
GLY A  37
ILE A 147
VAL A 311
PRO A  59
 None
 1.20A 1sg9A-4jbhA:
6.5		 1sg9A-4jbhA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m64 MELIBIOSE CARRIER
PROTEIN

(Salmonella
enterica) 		PF13347
(MFS_2) 		5 PHE A  16
ILE A 191
GLY A  14
THR A 194
VAL A 196
 None
 1.06A 1sg9A-4m64A:
undetectable		 1sg9A-4m64A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		5 PRO A 464
ILE A 484
GLY A 495
VAL A 526
SER A 527
 None
 0.95A 1sg9A-4n74A:
undetectable		 1sg9A-4n74A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
alaskensis) 		PF03480
(DctP) 		5 PRO A 221
GLY A 157
ILE A 160
VAL A 154
ASN A 219
 CL  A 401 (-3.8A)
CL  A 401 ( 3.8A)
DAL  A 402 (-4.9A)
None
DAL  A 403 (-2.9A)
 1.14A 1sg9A-4nguA:
undetectable		 1sg9A-4nguA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 186
GLY A  10
ILE A  86
VAL A   7
GLU A 244
 None
 1.11A 1sg9A-4qavA:
undetectable		 1sg9A-4qavA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 ILE A 130
GLY A 142
ILE A 139
VAL A  91
ASN A 177
 None
 1.25A 1sg9A-4qfuA:
undetectable		 1sg9A-4qfuA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpw GLYCOSYL HYDROLASE
FAMILY 10

(Bacteroides
intestinalis) 		no annotation 5 ILE A 212
GLY A 288
ILE A 290
THR A 187
GLU A 182
 None
 1.15A 1sg9A-4qpwA:
undetectable		 1sg9A-4qpwA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlg SEC14-LIKE PROTEIN 4

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		5 PRO A 199
ILE A 192
ILE A 219
GLU A 240
PHE A 241
 EDO  A 512 ( 4.7A)
None
None
None
None
 1.15A 1sg9A-4tlgA:
3.2		 1sg9A-4tlgA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toi 30S RIBOSOMAL
PROTEIN S2,RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00318
(Ribosomal_S2)
PF00575
(S1) 		5 ILE A 200
ILE A  41
VAL A   4
SER A   5
ASN A 203
 None
 1.04A 1sg9A-4toiA:
undetectable		 1sg9A-4toiA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 PRO A 350
ILE A  48
GLY A 328
ILE A  44
THR A 340
 None
 1.25A 1sg9A-4uplA:
undetectable		 1sg9A-4uplA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1

(Mus musculus) 		PF01501
(Glyco_transf_8) 		5 PRO A 215
ILE A 169
VAL A  96
GLU A 134
PHE A 130
 None
 1.12A 1sg9A-4wm0A:
undetectable		 1sg9A-4wm0A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 182
GLY A   8
ILE A  83
VAL A   5
GLU A 240
 None
 1.08A 1sg9A-4xoxA:
undetectable		 1sg9A-4xoxA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00632
(HECT) 		5 PHE A 607
ILE A 591
GLY A 609
THR A 721
GLU A 719
 None
 1.20A 1sg9A-4y07A:
undetectable		 1sg9A-4y07A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 PHE A 155
ILE A 149
ILE A 516
VAL A 160
PHE A 126
 None
 1.23A 1sg9A-4zajA:
2.3		 1sg9A-4zajA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zet C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER C

(Homo sapiens) 		PF00059
(Lectin_C) 		5 ILE A 182
GLY A 143
ILE A 205
SER A 145
GLU A 178
 None
None
None
None
MAN  A 303 (-2.4A)
 1.26A 1sg9A-4zetA:
undetectable		 1sg9A-4zetA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi5 P91

(metagenome) 		PF01738
(DLH) 		5 PHE A 119
ILE A 115
GLY A 142
SER A 200
PRO A  36
 None
 1.22A 1sg9A-4zi5A:
undetectable		 1sg9A-4zi5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3g M50

(Murid
betaherpesvirus
1) 		PF04541
(Herpes_U34) 		6 PHE A  75
ILE A  54
ILE A  21
THR A  51
VAL A  84
SER A  85
 None
 1.48A 1sg9A-5a3gA:
undetectable		 1sg9A-5a3gA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		5 ILE A1650
GLY A1554
THR A1623
SER A1037
PRO A1653
 None
 1.09A 1sg9A-5a42A:
undetectable		 1sg9A-5a42A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG

(Homo sapiens) 		PF00632
(HECT) 		5 PHE A 640
ILE A 624
GLY A 642
THR A 754
GLU A 752
 None
 1.21A 1sg9A-5c7mA:
undetectable		 1sg9A-5c7mA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		5 PHE A 260
ILE A 242
GLY A 258
THR A 246
ASN A 240
 NA  A 406 (-4.6A)
None
None
None
None
 1.06A 1sg9A-5ce9A:
undetectable		 1sg9A-5ce9A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm2 O-METHYLRANSFERASE

(Streptomyces
blastmyceticus) 		PF08241
(Methyltransf_11) 		5 ILE A  84
GLY A  87
ILE A 152
VAL A 108
SER A 109
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.2A)
None
 1.16A 1sg9A-5gm2A:
11.3		 1sg9A-5gm2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PHE A  98
PRO A  56
ILE A 397
GLY A 355
PHE A 163
 FAD  A 702 (-3.8A)
None
None
None
None
 1.16A 1sg9A-5i68A:
undetectable		 1sg9A-5i68A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 ILE A1419
ILE A1352
SER A1391
ASN A1351
PRO A1376
 None
 1.15A 1sg9A-5i6iA:
4.3		 1sg9A-5i6iA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 PHE A  83
GLY A  80
ILE A   7
VAL A 294
GLU A 335
 None
 1.22A 1sg9A-5ks8A:
3.8		 1sg9A-5ks8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1

(Leeuwenhoekiella
blandensis) 		no annotation 5 PHE A 176
GLY A 178
ILE A 189
THR A 195
GLU A 297
 None
 1.25A 1sg9A-5olkA:
3.3		 1sg9A-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 ILE A 255
GLY A 292
GLU A 253
ASN A 262
PRO A 258
 None
 1.17A 1sg9A-5ur2A:
5.2		 1sg9A-5ur2A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 5 GLY A 136
ILE A  89
THR A 144
GLU A  94
PRO A  66
 None
 1.19A 1sg9A-5vqdA:
undetectable		 1sg9A-5vqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE A1033
GLY A 991
ILE A 989
VAL A1047
PHE A1037
 None
 1.25A 1sg9A-5xogA:
undetectable		 1sg9A-5xogA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE

(Homo sapiens) 		no annotation 6 PRO A  77
ILE A 109
GLY A 112
THR A 132
VAL A 134
ASN A 184
 SAH  A 305 ( 4.8A)
None
SAH  A 305 (-3.4A)
SAH  A 305 (-4.4A)
SAH  A 305 (-4.1A)
SAH  A 305 (-3.4A)
 0.74A 1sg9A-6b92A:
16.7		 1sg9A-6b92A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 5 ILE A 836
GLY A 839
THR A 863
SER A 866
ASN A 910
 None
SAH  A1102 (-3.4A)
None
None
SAH  A1102 (-4.0A)
 1.25A 1sg9A-6d6yA:
12.1		 1sg9A-6d6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dcl HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1

(Homo sapiens) 		no annotation 5 ILE A 112
GLY A 172
THR A 116
GLU A 114
ASN A 174
 None
None
None
U  D   7 ( 3.5A)
None
 1.20A 1sg9A-6dclA:
undetectable		 1sg9A-6dclA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 5 PRO A  16
ILE A 295
GLY A 325
THR A 319
VAL A 368
 FAD  A 601 (-3.5A)
None
FAD  A 601 (-3.6A)
None
None
 1.11A 1sg9A-6em0A:
3.3		 1sg9A-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 5 ILE D 275
GLY D 307
ILE D 313
THR D 342
SER D 303
 None
 1.26A 1sg9A-6fkhD:
undetectable		 1sg9A-6fkhD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7a PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE

(Escherichia
coli) 		PF00731
(AIRC) 		4 THR A  22
GLY A 100
ASP A 102
ALA A  96
 None
 0.79A 1sg9A-1d7aA:
4.2		 1sg9A-1d7aA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy2 COLLAGEN ALPHA1(XV)
CHAIN

(Mus musculus) 		PF06482
(Endostatin) 		4 THR A 182
GLY A 177
ASP A 176
ALA A  90
 None
 1.25A 1sg9A-1dy2A:
undetectable		 1sg9A-1dy2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
PF02240
(MCR_gamma) 		4 THR B 404
GLY C  79
ASP C 133
ALA B 321
 None
 1.11A 1sg9A-1e6vB:
undetectable		 1sg9A-1e6vB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7u ARGINYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 THR A 349
GLY A 343
ASP A 342
ALA A 321
 None
None
None
C  B 974 ( 3.8A)
 1.23A 1sg9A-1f7uA:
2.8		 1sg9A-1f7uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geg ACETOIN REDUCTASE

(Klebsiella
pneumoniae) 		PF00106
(adh_short) 		4 THR A 187
GLY A  11
ASP A  33
ALA A  87
 NAD  A2001 (-2.7A)
NAD  A2001 ( 4.1A)
NAD  A2001 (-2.8A)
NAD  A2001 (-3.6A)
 1.18A 1sg9A-1gegA:
6.7		 1sg9A-1gegA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy8 LEVODIONE REDUCTASE

(Leifsonia
aquatica) 		PF13561
(adh_short_C2) 		4 THR A 200
GLY A  22
ASP A  44
ALA A 100
 NAD  A1268 (-2.8A)
NAD  A1268 ( 4.1A)
NAD  A1268 (-2.7A)
NAD  A1268 ( 3.7A)
 1.22A 1sg9A-1iy8A:
7.1		 1sg9A-1iy8A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE

(Homo sapiens) 		PF02574
(S-methyl_trans) 		4 THR A 184
GLY A  25
ASP A  26
ALA A 119
 None
 1.19A 1sg9A-1lt8A:
undetectable		 1sg9A-1lt8A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE

(Drosophila
melanogaster) 		PF00106
(adh_short) 		4 THR A 187
GLY A  14
ASP A  38
ALA A  93
 NAI  A 850 (-2.7A)
None
NAI  A 850 (-2.8A)
NAI  A 850 (-3.5A)
 1.25A 1sg9A-1mg5A:
6.1		 1sg9A-1mg5A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 THR A 387
GLY A 463
ASP A 459
ALA A 486
 None
 1.19A 1sg9A-1qhoA:
undetectable		 1sg9A-1qhoA:
17.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		4 THR A 106
GLY A 129
ASP A 151
ALA A 218
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
 0.00A 1sg9A-1sg9A:
46.2		 1sg9A-1sg9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 37 KDA
SUBUNIT

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1)
PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 THR B 120
GLY A 432
ASP A 433
ALA A 379
 None
 1.09A 1sg9A-1sxjB:
3.3		 1sg9A-1sxjB:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		4 THR A 145
GLY A  37
ASP A  36
ALA A  40
 None
 1.26A 1sg9A-1v4gA:
undetectable		 1sg9A-1v4gA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7e BETA-IG-H3/FASCICLIN

(Rhodobacter
sphaeroides) 		PF02469
(Fasciclin) 		4 THR A  37
GLY A 151
ASP A 150
ALA A  69
 None
 1.06A 1sg9A-1w7eA:
undetectable		 1sg9A-1w7eA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		4 THR A 373
GLY A 123
ASP A 122
ALA A 115
 None
 1.15A 1sg9A-1yniA:
undetectable		 1sg9A-1yniA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypf GMP REDUCTASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		4 THR A 177
GLY A 187
ASP A   6
ALA A 192
 None
 1.19A 1sg9A-1ypfA:
undetectable		 1sg9A-1ypfA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 THR A 738
GLY A 707
ASP A 710
ALA A 693
 None
 1.17A 1sg9A-1z8lA:
undetectable		 1sg9A-1z8lA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 THR A  95
GLY A 117
ASP A 140
ALA A 206
 SAH  A 300 ( 4.3A)
SAH  A 300 (-3.4A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.4A)
 0.26A 1sg9A-2b3tA:
29.0		 1sg9A-2b3tA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		4 THR A 239
GLY A 334
ASP A 291
ALA A 330
 None
 0.91A 1sg9A-2bs9A:
undetectable		 1sg9A-2bs9A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii) 		PF00294
(PfkB) 		4 THR A 111
GLY A 162
ASP A 160
ALA A  44
 ADN  A1301 (-3.1A)
MG  A1302 ( 4.4A)
MG  A1302 ( 4.1A)
ADN  A1301 ( 4.1A)
 1.14A 1sg9A-2c49A:
3.0		 1sg9A-2c49A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF10672
(Methyltrans_SAM) 		4 THR A 251
GLY A 141
ASP A 161
ALA A 191
 None
None
SAM  A1001 (-2.9A)
SAM  A1001 (-3.6A)
 1.27A 1sg9A-2igtA:
13.2		 1sg9A-2igtA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Escherichia
coli) 		PF00254
(FKBP_C) 		4 THR A  17
GLY A 121
ASP A 120
ALA A 126
 None
 1.20A 1sg9A-2k8iA:
undetectable		 1sg9A-2k8iA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa1 PDZ AND LIM DOMAIN
PROTEIN 2

(Homo sapiens) 		PF00595
(PDZ) 		4 THR A  30
GLY A  20
ASP A  22
ALA A  65
 None
 1.26A 1sg9A-2pa1A:
undetectable		 1sg9A-2pa1A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		4 THR A 449
GLY A  82
ASP A  80
ALA A 363
 None
 1.24A 1sg9A-2qa1A:
2.8		 1sg9A-2qa1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL) 		4 THR A 756
GLY A 600
ASP A 620
ALA A 680
 None
SAH  A1846 (-3.2A)
SAH  A1846 (-2.6A)
SAH  A1846 (-3.6A)
 1.10A 1sg9A-2vdwA:
11.3		 1sg9A-2vdwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz5 TAX1-BINDING PROTEIN
3

(Homo sapiens) 		PF00595
(PDZ) 		4 THR A  58
GLY A  36
ASP A  38
ALA A  93
 None
 1.13A 1sg9A-2vz5A:
undetectable		 1sg9A-2vz5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl7 DISKS LARGE HOMOLOG
2

(Mus musculus) 		PF00595
(PDZ) 		4 THR A 132
GLY A 117
ASP A 119
ALA A 168
 None
 1.21A 1sg9A-2wl7A:
undetectable		 1sg9A-2wl7A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsb GALACTITOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		4 THR A 194
GLY A  20
ASP A  42
ALA A  93
 NAD  A 500 (-2.7A)
NAD  A 500 ( 3.8A)
NAD  A 500 (-2.8A)
NAD  A 500 (-3.6A)
 1.24A 1sg9A-2wsbA:
6.8		 1sg9A-2wsbA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 THR A 424
GLY A 546
ASP A 548
ALA A 449
 None
 1.01A 1sg9A-2x2iA:
undetectable		 1sg9A-2x2iA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		4 THR A  79
GLY A 101
ASP A 105
ALA A 144
 J60  A1294 ( 4.2A)
J60  A1294 ( 3.8A)
J60  A1294 (-3.2A)
None
 1.24A 1sg9A-2xikA:
undetectable		 1sg9A-2xikA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 THR A 553
GLY A 541
ASP A 467
ALA A 399
 None
None
MG  A2487 (-2.9A)
None
 1.03A 1sg9A-2xkkA:
2.4		 1sg9A-2xkkA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y93 CIS-2,3-DIHYDROBIPHE
NYL-2,3-DIOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF00106
(adh_short) 		4 THR A 189
GLY A  13
ASP A  36
ALA A  87
 None
 1.24A 1sg9A-2y93A:
6.0		 1sg9A-2y93A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 THR A 387
GLY A 382
ASP A 381
ALA A 200
 None
 1.20A 1sg9A-2z0fA:
undetectable		 1sg9A-2z0fA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum) 		no annotation 4 THR C 189
GLY C  10
ASP C  33
ALA C  89
 NAD  C4300 (-2.6A)
None
NAD  C4300 (-3.0A)
NAD  C4300 ( 3.8A)
 1.24A 1sg9A-3a28C:
6.3		 1sg9A-3a28C:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 THR A 353
GLY A 181
ASP A 147
ALA A 359
 None
 0.99A 1sg9A-3afgA:
2.0		 1sg9A-3afgA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak4 NADH-DEPENDENT
QUINUCLIDINONE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		4 THR A 191
GLY A  17
ASP A  40
ALA A  91
 NAD  A 901 (-2.8A)
None
NAD  A 901 (-2.8A)
NAD  A 901 ( 3.7A)
 1.27A 1sg9A-3ak4A:
6.2		 1sg9A-3ak4A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7f GLYCOSYL HYDROLASE,
BNR REPEAT

(Cupriavidus
pinatubonensis) 		no annotation 4 THR A 291
GLY A 354
ASP A 348
ALA A 351
 EDO  A 400 (-3.1A)
None
None
None
 1.02A 1sg9A-3b7fA:
undetectable		 1sg9A-3b7fA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c41 AMINO ACID ABC
TRANSPORTER (ARTP)

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 THR J 193
GLY J 203
ASP J 204
ALA J 183
 None
 1.16A 1sg9A-3c41J:
2.4		 1sg9A-3c41J:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7o ENDO-1,4-BETA-XYLANA
SE

(Bacillus
subtilis) 		PF03422
(CBM_6)
PF04616
(Glyco_hydro_43) 		4 THR A 149
GLY A 144
ASP A 141
ALA A  97
 GOL  A1734 ( 4.3A)
None
None
None
 1.05A 1sg9A-3c7oA:
undetectable		 1sg9A-3c7oA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A  43
GLY A 118
ASP A 117
ALA A   5
 None
 1.19A 1sg9A-3fsrA:
5.9		 1sg9A-3fsrA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 THR A 181
GLY A 240
ASP A 241
ALA A 159
 None
None
GOL  A 513 (-2.7A)
None
 1.27A 1sg9A-3hz6A:
undetectable		 1sg9A-3hz6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j08 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 THR A 428
GLY A 646
ASP A 647
ALA A 629
 None
 1.13A 1sg9A-3j08A:
2.9		 1sg9A-3j08A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd9 COENZYME A DISULFIDE
REDUCTASE

(Pyrococcus
horikoshii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 THR A  37
GLY A 111
ASP A 280
ALA A  13
 None
 0.88A 1sg9A-3kd9A:
3.0		 1sg9A-3kd9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE

(Yersinia pestis) 		PF00731
(AIRC) 		4 THR A  27
GLY A 105
ASP A 107
ALA A 101
 SO4  A 175 ( 4.2A)
None
None
SO4  A 176 (-3.5A)
 0.79A 1sg9A-3kuuA:
4.1		 1sg9A-3kuuA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lr1 TUNGSTATE ABC
TRANSPORTER,
PERIPLASMIC
TUNGSTATE-BINDING
PROTEIN

(Geobacter
sulfurreducens) 		PF12849
(PBP_like_2) 		4 THR A 110
GLY A  94
ASP A  91
ALA A  98
 None
 1.20A 1sg9A-3lr1A:
undetectable		 1sg9A-3lr1A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv3 COATOMER SUBUNIT
EPSILON

(Saccharomyces
cerevisiae) 		PF04733
(Coatomer_E) 		4 THR B  29
GLY B  57
ASP B  61
ALA B  38
 None
 1.25A 1sg9A-3mv3B:
2.3		 1sg9A-3mv3B:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 305
GLY A 401
ASP A 265
ALA A 279
 None
 1.16A 1sg9A-3o04A:
undetectable		 1sg9A-3o04A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz4 ENDO-1,4-BETA-XYLANA
SE D

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		4 THR A 152
GLY A 147
ASP A 145
ALA A  95
 None
 1.19A 1sg9A-3qz4A:
undetectable		 1sg9A-3qz4A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl7 DISKS LARGE HOMOLOG
1

(Homo sapiens) 		no annotation 4 THR B 256
GLY B 241
ASP B 243
ALA B 292
 None
 1.24A 1sg9A-3rl7B:
undetectable		 1sg9A-3rl7B:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 THR A 165
GLY A 379
ASP A 270
ALA A 376
 None
 1.21A 1sg9A-3rv2A:
undetectable		 1sg9A-3rv2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wye DIACETYL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING]

(Klebsiella
pneumoniae;
Corynebacterium
glutamicum) 		PF13561
(adh_short_C2) 		4 THR A 187
GLY A  11
ASP A  33
ALA A  87
 NAD  A 301 (-2.7A)
NAD  A 301 ( 4.2A)
NAD  A 301 (-2.8A)
NAD  A 301 ( 3.7A)
 1.19A 1sg9A-3wyeA:
6.5		 1sg9A-3wyeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgt CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 THR A 386
GLY A 462
ASP A 458
ALA A 485
 None
 1.22A 1sg9A-4cgtA:
undetectable		 1sg9A-4cgtA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 THR A 369
GLY A 426
ASP A 216
ALA A 429
 None
 0.73A 1sg9A-4f7kA:
undetectable		 1sg9A-4f7kA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		4 THR B  83
GLY B 105
ASP B 109
ALA B 148
 None
GOL  B1000 ( 3.9A)
None
None
 1.20A 1sg9A-4fzdB:
undetectable		 1sg9A-4fzdB:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		4 THR A 137
GLY A 115
ASP A 112
ALA A  62
 None
None
None
CL  A 403 ( 4.1A)
 1.22A 1sg9A-4h59A:
3.3		 1sg9A-4h59A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 161
GLY A 111
ASP A  72
ALA A 194
 None
 1.19A 1sg9A-4jb6A:
undetectable		 1sg9A-4jb6A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 306
GLY A 402
ASP A 266
ALA A 280
 None
 1.15A 1sg9A-4jb6A:
undetectable		 1sg9A-4jb6A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11

(synthetic
construct) 		PF01353
(GFP) 		4 THR C 106
GLY C 102
ASP C 101
ALA C 215
 None
 1.26A 1sg9A-4kf5C:
undetectable		 1sg9A-4kf5C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		4 THR A 210
GLY A 142
ASP A  25
ALA A 183
 None
CA  A 400 ( 4.4A)
CA  A 400 (-2.9A)
None
 1.23A 1sg9A-4kpnA:
4.0		 1sg9A-4kpnA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		4 THR A 261
GLY A 142
ASP A  25
ALA A 183
 None
CA  A 400 ( 4.4A)
CA  A 400 (-2.9A)
None
 1.27A 1sg9A-4kpnA:
4.0		 1sg9A-4kpnA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		4 THR A 192
GLY A 124
ASP A   8
ALA A 165
 None
CA  A 401 ( 4.3A)
CA  A 401 (-3.1A)
None
 1.13A 1sg9A-4kpoA:
3.9		 1sg9A-4kpoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Acholeplasma
laidlawii) 		PF13561
(adh_short_C2) 		4 THR A 183
GLY A  14
ASP A  37
ALA A  82
 NAD  A 301 (-2.7A)
None
NAD  A 301 (-2.5A)
NAD  A 301 (-3.6A)
 1.24A 1sg9A-4nbtA:
6.0		 1sg9A-4nbtA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnm TAX1-BINDING PROTEIN
3

(Homo sapiens) 		PF00595
(PDZ) 		4 THR A  59
GLY A  37
ASP A  39
ALA A  94
 None
 1.23A 1sg9A-4nnmA:
undetectable		 1sg9A-4nnmA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		4 THR B  83
GLY B 105
ASP B 109
ALA B 148
 ADP  B 500 ( 4.9A)
None
None
None
 1.22A 1sg9A-4o27B:
undetectable		 1sg9A-4o27B:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 4 THR A  14
GLY A 194
ASP A 191
ALA A  21
 CA  A 512 (-3.1A)
None
CA  A 515 (-3.5A)
None
 1.04A 1sg9A-4p99A:
undetectable		 1sg9A-4p99A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 4 THR A 118
GLY A 298
ASP A 295
ALA A 125
 CA  A 517 (-3.0A)
None
CA  A 519 (-3.3A)
None
 1.05A 1sg9A-4p99A:
undetectable		 1sg9A-4p99A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 4 THR A 222
GLY A 402
ASP A 399
ALA A 229
 CA  A 503 (-3.0A)
None
CA  A 501 (-3.4A)
None
 0.99A 1sg9A-4p99A:
undetectable		 1sg9A-4p99A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 305
GLY A 402
ASP A 265
ALA A 279
 None
 1.19A 1sg9A-4r8eA:
undetectable		 1sg9A-4r8eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzm EPOXIDE HYDROLASE
LASB

(Streptomyces
lasaliensis) 		PF12680
(SnoaL_2) 		4 THR A  42
GLY A 208
ASP A 135
ALA A 204
 None
 1.20A 1sg9A-4rzmA:
undetectable		 1sg9A-4rzmA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tma DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 THR B 753
GLY B 741
ASP B 498
ALA B 428
 None
 0.89A 1sg9A-4tmaB:
undetectable		 1sg9A-4tmaB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcz ENOYL-COA
HYDRATASE/ISOMERASE

(Novosphingobium
aromaticivorans) 		PF00378
(ECH_1) 		4 THR A  99
GLY A 113
ASP A 144
ALA A  88
 None
 1.27A 1sg9A-4wczA:
undetectable		 1sg9A-4wczA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
ALPHA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		4 THR A 105
GLY A 208
ASP A 209
ALA A  89
 None
 0.91A 1sg9A-4wvmA:
2.4		 1sg9A-4wvmA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
BETA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		4 THR B 106
GLY B 209
ASP B 210
ALA B  90
 None
 0.97A 1sg9A-4wvmB:
undetectable		 1sg9A-4wvmB:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF13458
(Peripla_BP_6) 		4 THR A 315
GLY A 322
ASP A 440
ALA A 327
 None
 1.17A 1sg9A-4xfkA:
5.0		 1sg9A-4xfkA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		no annotation 4 THR J 193
GLY J 203
ASP J 204
ALA J 183
 None
 1.14A 1sg9A-4ymwJ:
2.7		 1sg9A-4ymwJ:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		4 THR A 280
GLY A 229
ASP A 182
ALA A 233
 None
 1.17A 1sg9A-4yyfA:
undetectable		 1sg9A-4yyfA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5y COENZYME PQQ
SYNTHESIS PROTEIN B

(Pseudomonas
putida) 		PF12706
(Lactamase_B_2) 		4 THR A 273
GLY A 221
ASP A 220
ALA A 246
 None
 1.16A 1sg9A-4z5yA:
undetectable		 1sg9A-4z5yA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		4 THR A1158
GLY A1034
ASP A1035
ALA A1126
 None
 1.20A 1sg9A-4ziuA:
undetectable		 1sg9A-4ziuA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 THR A1158
GLY A1034
ASP A1035
ALA A1126
 None
 1.26A 1sg9A-5a42A:
undetectable		 1sg9A-5a42A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 THR A  61
GLY A  81
ASP A  82
ALA A 267
 None
 1.20A 1sg9A-5a4jA:
undetectable		 1sg9A-5a4jA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
PF02240
(MCR_gamma) 		4 THR B 403
GLY C  78
ASP C 132
ALA B 320
 None
 1.14A 1sg9A-5a8rB:
undetectable		 1sg9A-5a8rB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		4 THR A 414
GLY A 524
ASP A 519
ALA A 527
 None
 1.26A 1sg9A-5az4A:
undetectable		 1sg9A-5az4A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 THR A 272
GLY A 333
ASP A 338
ALA A 299
 THR  A 272 ( 0.8A)
GLY  A 333 ( 0.0A)
ASP  A 338 (-0.5A)
ALA  A 299 ( 0.0A)
 1.25A 1sg9A-5d7wA:
undetectable		 1sg9A-5d7wA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 THR A 272
GLY A 334
ASP A 338
ALA A 299
 THR  A 272 ( 0.8A)
GLY  A 334 (-0.0A)
ASP  A 338 (-0.5A)
ALA  A 299 ( 0.0A)
 0.90A 1sg9A-5d7wA:
undetectable		 1sg9A-5d7wA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 THR A 189
GLY A  18
ASP A  40
ALA A  90
 NAD  A 301 (-2.8A)
NAD  A 301 ( 4.2A)
NAD  A 301 (-2.8A)
NAD  A 301 ( 3.8A)
 1.20A 1sg9A-5en4A:
6.5		 1sg9A-5en4A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 THR A 117
GLY A  97
ASP A  96
ALA A  26
 None
 1.16A 1sg9A-5fp1A:
undetectable		 1sg9A-5fp1A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 4 THR A  22
GLY A 323
ASP A 322
ALA A 320
 None
None
CA  A1351 (-2.3A)
None
 1.08A 1sg9A-5fzpA:
undetectable		 1sg9A-5fzpA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irb RTX-ADHESIN

(Marinomonas
primoryensis) 		no annotation 4 THR A 197
GLY A 376
ASP A 373
ALA A 204
 CA  A 601 (-3.2A)
None
None
None
 1.10A 1sg9A-5irbA:
undetectable		 1sg9A-5irbA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irb RTX-ADHESIN

(Marinomonas
primoryensis) 		no annotation 4 THR A 301
GLY A 480
ASP A 477
ALA A 308
 CA  A 604 (-3.0A)
None
CA  A 602 (-3.2A)
None
 1.11A 1sg9A-5irbA:
undetectable		 1sg9A-5irbA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itw DIHYDROANTICAPSIN
7-DEHYDROGENASE

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		4 THR A 189
GLY A  15
ASP A  38
ALA A  90
 SO4  A 302 ( 3.9A)
None
None
None
 1.22A 1sg9A-5itwA:
6.9		 1sg9A-5itwA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		4 THR A 188
GLY A  18
ASP A  40
ALA A  89
 NAD  A 401 (-2.5A)
NAD  A 401 ( 4.0A)
NAD  A 401 (-2.9A)
NAD  A 401 (-3.6A)
 1.25A 1sg9A-5jlaA:
6.3		 1sg9A-5jlaA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2x DNA-DIRECTED
PRIMASE/POLYMERASE
PROTEIN

(Homo sapiens) 		no annotation 4 THR A 307
GLY A 127
ASP A 126
ALA A 132
 None
 0.84A 1sg9A-5l2xA:
undetectable		 1sg9A-5l2xA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 4 THR A 196
GLY A 441
ASP A 442
ALA A 274
 None
PO4  A 504 (-3.3A)
GLC  A 501 ( 2.6A)
GLC  A 501 ( 4.3A)
 1.04A 1sg9A-5od2A:
3.9		 1sg9A-5od2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 THR C 962
GLY C 702
ASP C 695
ALA C 705
 None
 1.24A 1sg9A-5tw1C:
undetectable		 1sg9A-5tw1C:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 THR A 179
GLY A  10
ASP A  69
ALA A  99
 GTP  A 501 (-3.6A)
GTP  A 501 (-2.2A)
GTP  A 501 ( 2.1A)
GTP  A 501 (-2.9A)
 1.11A 1sg9A-5ucyA:
undetectable		 1sg9A-5ucyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4s TRANSPORTER, CATION
CHANNEL FAMILY /
CYCLIC
NUCLEOTIDE-BINDING
DOMAIN MULTI-DOMAIN
PROTEIN

(Leptospira
licerasiae) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans) 		4 THR A 213
GLY A 200
ASP A 201
ALA A 192
 None
 1.19A 1sg9A-5v4sA:
2.0		 1sg9A-5v4sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 4 THR A  43
GLY A 337
ASP A 378
ALA A 333
 None
 1.22A 1sg9A-5x7nA:
undetectable		 1sg9A-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbj FLAGELLAR
HOOK-ASSOCIATED
PROTEIN FLGK

(Campylobacter
jejuni) 		no annotation 4 THR A 366
GLY A 470
ASP A 475
ALA A 327
 None
 1.02A 1sg9A-5xbjA:
undetectable		 1sg9A-5xbjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9y SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		no annotation 4 THR A 192
GLY A  16
ASP A  39
ALA A  92
 None
 1.23A 1sg9A-6d9yA:
7.1		 1sg9A-6d9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekv TOXIN COMPLEX
COMPONENT ORF-X2

(Clostridium
botulinum) 		no annotation 4 THR A 177
GLY A 713
ASP A 274
ALA A 348
 None
 1.07A 1sg9A-6ekvA:
undetectable		 1sg9A-6ekvA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 4 THR A  91
GLY A  72
ASP A  60
ALA A 167
 None
None
None
EDO  A 802 ( 4.2A)
 1.10A 1sg9A-6f8zA:
undetectable		 1sg9A-6f8zA:
undetectable