SIMILAR PATTERNS OF AMINO ACIDS FOR 1SBR_B_VIBB504_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6q HNRNP ARGININE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF06325
(PrmA) 		4 PRO 1 292
HIS 1 203
PHE 1 137
ILE 1 323
 None
 1.22A 1sbrA-1g6q1:
0.6
1sbrB-1g6q1:
undetectable		 1sbrA-1g6q1:
20.78
1sbrB-1g6q1:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		4 HIS A 221
LEU A 276
ILE A  12
SER A 140
 UDP  A1383 (-4.2A)
None
NAD  A1382 (-3.8A)
NAD  A1382 (-3.9A)
 1.19A 1sbrA-1gy8A:
undetectable
1sbrB-1gy8A:
0.0		 1sbrA-1gy8A:
19.80
1sbrB-1gy8A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm7 PENTALENENE SYNTHASE

(Streptomyces
exfoliatus) 		no annotation 4 PRO A 181
LEU A 216
ILE A 177
SER A 305
 None
 1.23A 1sbrA-1hm7A:
undetectable
1sbrB-1hm7A:
0.5		 1sbrA-1hm7A:
19.88
1sbrB-1hm7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy2 FIBRINOGEN ALPHA
CHAIN
FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA-B
CHAIN

(Bos taurus) 		PF08702
(Fib_alpha) 		4 PRO O  84
PHE P  28
LEU P  29
ILE N  58
 None
 1.19A 1sbrA-1jy2O:
undetectable
1sbrB-1jy2O:
undetectable		 1sbrA-1jy2O:
20.51
1sbrB-1jy2O:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 HIS A 130
PHE A 177
LEU A 174
ILE A 175
 None
 1.15A 1sbrA-1o5tA:
0.0
1sbrB-1o5tA:
undetectable		 1sbrA-1o5tA:
19.16
1sbrB-1o5tA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 PRO A 784
HIS A 785
LEU A 112
ILE A 117
 None
 1.09A 1sbrA-1obhA:
0.0
1sbrB-1obhA:
0.0		 1sbrA-1obhA:
12.30
1sbrB-1obhA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pww LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		4 PRO A 127
PHE A 217
LEU A 155
ILE A 159
 None
 1.20A 1sbrA-1pwwA:
undetectable
1sbrB-1pwwA:
0.0		 1sbrA-1pwwA:
13.55
1sbrB-1pwwA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz3 HYPOTHETICAL PROTEIN
RBSTP0775

(Geobacillus
stearothermophilus) 		PF00485
(PRK) 		4 HIS A  57
LEU A  38
ILE A  27
SER A  33
 None
 1.17A 1sbrA-1rz3A:
0.0
1sbrB-1rz3A:
0.0		 1sbrA-1rz3A:
24.43
1sbrB-1rz3A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s21 ORF2

(Pseudomonas
savastanoi) 		PF09143
(AvrPphF-ORF-2) 		4 PRO A  58
HIS A  97
ILE A  94
SER A 133
 None
 1.07A 1sbrA-1s21A:
undetectable
1sbrB-1s21A:
0.0		 1sbrA-1s21A:
24.17
1sbrB-1s21A:
24.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s7h YKOF

(Bacillus
subtilis) 		PF07615
(Ykof) 		4 PHE A 119
LEU A 121
ILE A 133
SER A 154
 None
 0.38A 1sbrA-1s7hA:
33.9
1sbrB-1s7hA:
33.9		 1sbrA-1s7hA:
99.00
1sbrB-1s7hA:
99.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		4 PRO A 113
PHE A 200
LEU A 205
ILE A 208
 None
 1.20A 1sbrA-1sezA:
undetectable
1sbrB-1sezA:
undetectable		 1sbrA-1sezA:
16.87
1sbrB-1sezA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr1 BETA-GLUCOSIDASE A

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		4 HIS A 102
PHE A 208
ILE A 158
SER A 214
 None
 1.17A 1sbrA-1tr1A:
undetectable
1sbrB-1tr1A:
undetectable		 1sbrA-1tr1A:
17.04
1sbrB-1tr1A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus
coagulans) 		PF00180
(Iso_dh) 		4 PRO A 107
PHE A 308
LEU A 304
SER A 307
 None
 1.00A 1sbrA-1v5bA:
undetectable
1sbrB-1v5bA:
undetectable		 1sbrA-1v5bA:
19.58
1sbrB-1v5bA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00180
(Iso_dh) 		4 PRO A 106
PHE A 303
LEU A 299
SER A 302
 None
 1.04A 1sbrA-1vlcA:
undetectable
1sbrB-1vlcA:
undetectable		 1sbrA-1vlcA:
18.40
1sbrB-1vlcA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxi DNA POLYMERASE III
SUBUNIT GAMMA

(Escherichia
coli) 		PF12169
(DNA_pol3_gamma3)
PF13177
(DNA_pol3_delta2) 		4 PRO B 361
HIS B 360
LEU B 316
ILE B 320
 None
 1.06A 1sbrA-1xxiB:
undetectable
1sbrB-1xxiB:
undetectable		 1sbrA-1xxiB:
20.97
1sbrB-1xxiB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ECDYSONE RECEPTOR
LIGAND BINDING
DOMAIN
ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		4 PRO E 338
PHE U 348
ILE U 463
SER U 349
 PO4  U   1 ( 4.7A)
None
None
None
 1.01A 1sbrA-1z5xE:
undetectable
1sbrB-1z5xE:
undetectable		 1sbrA-1z5xE:
20.79
1sbrB-1z5xE:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrm L-2-HALOACID
DEHALOGENASE

(Pseudomonas sp.
YL) 		PF13419
(HAD_2) 		4 PRO A 190
PHE A 138
LEU A 114
ILE A   7
 None
 1.17A 1sbrA-1zrmA:
undetectable
1sbrB-1zrmA:
undetectable		 1sbrA-1zrmA:
24.91
1sbrB-1zrmA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acm MUCIN-1

(Homo sapiens) 		PF01390
(SEA) 		4 PRO A1061
PHE A1077
LEU A1089
ILE A1092
 None
 1.22A 1sbrA-2acmA:
undetectable
1sbrB-2acmA:
undetectable		 1sbrA-2acmA:
17.44
1sbrB-2acmA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cja SERYL-TRNA
SYNTHETASE

(Methanosarcina
barkeri) 		no annotation 4 PRO A 422
HIS A 179
PHE A 380
LEU A 384
 None
 1.14A 1sbrA-2cjaA:
undetectable
1sbrB-2cjaA:
4.1		 1sbrA-2cjaA:
18.78
1sbrB-2cjaA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9h EXTRACELLULAR
ENTEROTOXIN TYPE I

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 HIS D 105
PHE D 206
LEU D 208
ILE D  97
 None
 1.08A 1sbrA-2g9hD:
undetectable
1sbrB-2g9hD:
undetectable		 1sbrA-2g9hD:
19.91
1sbrB-2g9hD:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Sulfurisphaera
tokodaii) 		PF04321
(RmlD_sub_bind) 		4 PRO A  58
LEU A  16
ILE A   5
SER A  21
 None
 1.15A 1sbrA-2ggsA:
undetectable
1sbrB-2ggsA:
undetectable		 1sbrA-2ggsA:
23.02
1sbrB-2ggsA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00698
(Acyl_transf_1)
PF16197
(KAsynt_C_assoc) 		4 PHE A 516
LEU A 563
ILE A 564
SER A 519
 None
 1.14A 1sbrA-2jfdA:
2.2
1sbrB-2jfdA:
2.1		 1sbrA-2jfdA:
19.17
1sbrB-2jfdA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jmz HYPOTHETICAL PROTEIN
MJ0781

(Methanocaldococcus
jannaschii) 		PF14890
(Intein_splicing) 		4 PRO A 104
HIS A 103
LEU A 155
SER A  61
 None
 1.20A 1sbrA-2jmzA:
undetectable
1sbrB-2jmzA:
undetectable		 1sbrA-2jmzA:
18.40
1sbrB-2jmzA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jwp MALECTIN

(Xenopus laevis) 		PF11721
(Malectin) 		4 PRO A  33
PHE A 149
LEU A 153
ILE A  75
 None
 1.16A 1sbrA-2jwpA:
undetectable
1sbrB-2jwpA:
undetectable		 1sbrA-2jwpA:
21.95
1sbrB-2jwpA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C) 		4 HIS A 105
PHE A 207
LEU A 209
ILE A  97
 None
 1.16A 1sbrA-2nttA:
undetectable
1sbrB-2nttA:
undetectable		 1sbrA-2nttA:
19.83
1sbrB-2nttA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		4 PRO E 469
PHE A 259
ILE A 374
SER A 260
 None
 1.22A 1sbrA-2nxxE:
undetectable
1sbrB-2nxxE:
undetectable		 1sbrA-2nxxE:
20.31
1sbrB-2nxxE:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE

(Plasmodium
falciparum) 		PF00175
(NAD_binding_1) 		4 PHE A 193
LEU A 192
ILE A 167
SER A 205
 None
 1.11A 1sbrA-2ok8A:
undetectable
1sbrB-2ok8A:
undetectable		 1sbrA-2ok8A:
18.60
1sbrB-2ok8A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb7 E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF02182
(SAD_SRA) 		4 PRO A 444
HIS A 442
LEU A 508
SER A 481
 None
 1.22A 1sbrA-2pb7A:
undetectable
1sbrB-2pb7A:
undetectable		 1sbrA-2pb7A:
23.37
1sbrB-2pb7A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)

(Candida
albicans) 		PF01380
(SIS) 		4 PRO A 669
PHE A 375
LEU A 539
ILE A 542
 None
 1.07A 1sbrA-2putA:
undetectable
1sbrB-2putA:
undetectable		 1sbrA-2putA:
19.68
1sbrB-2putA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q66 POLY(A) POLYMERASE

(Saccharomyces
cerevisiae) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		4 PRO A 404
HIS A 403
PHE A 328
LEU A 325
 None
 1.16A 1sbrA-2q66A:
2.0
1sbrB-2q66A:
undetectable		 1sbrA-2q66A:
16.19
1sbrB-2q66A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 HIS A  27
LEU A 119
ILE A  96
SER A 123
 CL  A 601 ( 4.2A)
None
None
None
 1.18A 1sbrA-2r7mA:
undetectable
1sbrB-2r7mA:
undetectable		 1sbrA-2r7mA:
20.88
1sbrB-2r7mA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		4 PRO A  27
HIS A  53
LEU A 279
ILE A 103
 None
 1.09A 1sbrA-2vg2A:
undetectable
1sbrB-2vg2A:
undetectable		 1sbrA-2vg2A:
21.40
1sbrB-2vg2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 PRO A 527
HIS A 526
PHE A  19
SER A  42
 None
 1.23A 1sbrA-2vobA:
undetectable
1sbrB-2vobA:
undetectable		 1sbrA-2vobA:
14.57
1sbrB-2vobA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vza CELL FILAMENTATION
PROTEIN

(Bartonella
henselae) 		PF02661
(Fic) 		4 PRO A 244
PHE A 266
LEU A 268
ILE A 275
 None
 1.09A 1sbrA-2vzaA:
undetectable
1sbrB-2vzaA:
undetectable		 1sbrA-2vzaA:
22.82
1sbrB-2vzaA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		4 PRO A  84
PHE A  16
LEU A  35
ILE A  78
 None
 1.22A 1sbrA-2wzgA:
undetectable
1sbrB-2wzgA:
undetectable		 1sbrA-2wzgA:
16.38
1sbrB-2wzgA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 PRO B 201
PHE B 217
LEU B 219
ILE B 168
 None
 1.24A 1sbrA-2xdqB:
undetectable
1sbrB-2xdqB:
undetectable		 1sbrA-2xdqB:
19.68
1sbrB-2xdqB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		4 HIS A 599
LEU A 225
ILE A 224
SER A 187
 None
 1.19A 1sbrA-2xheA:
undetectable
1sbrB-2xheA:
undetectable		 1sbrA-2xheA:
15.82
1sbrB-2xheA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xri ERI1 EXORIBONUCLEASE
3

(Homo sapiens) 		PF00929
(RNase_T) 		4 PRO A 169
PHE A 330
LEU A 275
ILE A 316
 None
 0.95A 1sbrA-2xriA:
undetectable
1sbrB-2xriA:
undetectable		 1sbrA-2xriA:
18.70
1sbrB-2xriA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygt DELTA TOXIN

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		4 PRO A  88
LEU A 246
ILE A  69
SER A  40
 None
 1.20A 1sbrA-2ygtA:
undetectable
1sbrB-2ygtA:
1.7		 1sbrA-2ygtA:
20.74
1sbrB-2ygtA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Plasmodium
vivax) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 PRO A  68
LEU A 137
ILE A 138
SER A 134
 None
 1.03A 1sbrA-2yneA:
undetectable
1sbrB-2yneA:
undetectable		 1sbrA-2yneA:
18.44
1sbrB-2yneA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		4 PRO A 304
HIS A 329
LEU A 309
SER A  73
 None
 1.12A 1sbrA-2z2zA:
undetectable
1sbrB-2z2zA:
undetectable		 1sbrA-2z2zA:
19.90
1sbrB-2z2zA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba0 MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		4 PRO A 146
HIS A 112
LEU A 281
SER A 277
 None
 1.03A 1sbrA-3ba0A:
undetectable
1sbrB-3ba0A:
undetectable		 1sbrA-3ba0A:
19.51
1sbrB-3ba0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF02182
(SAD_SRA) 		4 PRO A 444
HIS A 442
LEU A 508
SER A 481
 None
 1.23A 1sbrA-3dwhA:
undetectable
1sbrB-3dwhA:
undetectable		 1sbrA-3dwhA:
21.70
1sbrB-3dwhA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 PRO A  54
HIS A 161
LEU A 183
SER A 265
 None
None
None
PLP  A 401 (-2.6A)
 1.16A 1sbrA-3dwiA:
undetectable
1sbrB-3dwiA:
undetectable		 1sbrA-3dwiA:
20.74
1sbrB-3dwiA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2v 3'-5'-EXONUCLEASE

(Saccharomyces
cerevisiae) 		PF01026
(TatD_DNase) 		4 PRO A 318
PHE A 234
LEU A 292
ILE A 296
 None
 1.11A 1sbrA-3e2vA:
undetectable
1sbrB-3e2vA:
undetectable		 1sbrA-3e2vA:
18.59
1sbrB-3e2vA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eod PROTEIN HNR

(Escherichia
coli) 		PF00072
(Response_reg) 		4 PRO A  52
LEU A  23
ILE A  12
SER A  28
 None
 1.12A 1sbrA-3eodA:
undetectable
1sbrB-3eodA:
undetectable		 1sbrA-3eodA:
21.21
1sbrB-3eodA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3o VACUOLAR TRANSPORTER
CHAPERONE 2

(Saccharomyces
cerevisiae) 		PF09359
(VTC) 		4 HIS A 446
PHE A 359
LEU A 343
ILE A 318
 None
 1.19A 1sbrA-3g3oA:
undetectable
1sbrB-3g3oA:
undetectable		 1sbrA-3g3oA:
18.04
1sbrB-3g3oA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 HIS A 321
LEU A 307
ILE A 328
SER A 362
 None
 1.09A 1sbrA-3h2zA:
undetectable
1sbrB-3h2zA:
undetectable		 1sbrA-3h2zA:
20.77
1sbrB-3h2zA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 PRO B 120
LEU B 349
ILE B 161
SER B  30
 None
 1.04A 1sbrA-3hkzB:
undetectable
1sbrB-3hkzB:
undetectable		 1sbrA-3hkzB:
10.51
1sbrB-3hkzB:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF00579
(tRNA-synt_1b) 		4 HIS A  47
PHE A  94
LEU A  91
ILE A  92
 None
 1.17A 1sbrA-3i05A:
undetectable
1sbrB-3i05A:
undetectable		 1sbrA-3i05A:
20.82
1sbrB-3i05A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3A

(Saccharomyces
cerevisiae) 		PF00411
(Ribosomal_S11) 		4 PHE o 290
LEU o 286
ILE o 260
SER o 293
 None
 1.21A 1sbrA-3japo:
undetectable
1sbrB-3japo:
undetectable		 1sbrA-3japo:
16.58
1sbrB-3japo:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfv TIGHT JUNCTION
PROTEIN ZO-3

(Homo sapiens) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 PRO A 634
PHE A 753
LEU A 752
ILE A 697
 None
 1.20A 1sbrA-3kfvA:
undetectable
1sbrB-3kfvA:
undetectable		 1sbrA-3kfvA:
20.36
1sbrB-3kfvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5h HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 PHE A  82
LEU A  61
ILE A  88
SER A  84
 None
 1.18A 1sbrA-3m5hA:
undetectable
1sbrB-3m5hA:
undetectable		 1sbrA-3m5hA:
19.69
1sbrB-3m5hA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgx PUTATIVE P450
MONOOXYGENASE

(Amycolatopsis
balhimycina) 		PF00067
(p450) 		4 PRO A  12
LEU A 286
ILE A  72
SER A  47
 None
 1.18A 1sbrA-3mgxA:
undetectable
1sbrB-3mgxA:
undetectable		 1sbrA-3mgxA:
20.19
1sbrB-3mgxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhm RESPONSE REGULATOR

(Myxococcus
xanthus) 		PF00072
(Response_reg) 		4 PRO A  62
LEU A  34
ILE A  23
SER A  39
 None
 1.20A 1sbrA-3nhmA:
undetectable
1sbrB-3nhmA:
undetectable		 1sbrA-3nhmA:
19.00
1sbrB-3nhmA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 HIS A 458
LEU A 463
ILE A 270
SER A 276
 None
None
FAD  A 690 (-4.6A)
None
 1.14A 1sbrA-3pvcA:
undetectable
1sbrB-3pvcA:
undetectable		 1sbrA-3pvcA:
14.71
1sbrB-3pvcA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 PHE A 279
LEU A 247
ILE A 236
SER A 249
 None
 1.21A 1sbrA-3slkA:
1.2
1sbrB-3slkA:
1.3		 1sbrA-3slkA:
13.39
1sbrB-3slkA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1h 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus sp.
(in: Bacteria)) 		PF00180
(Iso_dh) 		4 PRO A 107
PHE A 308
LEU A 304
SER A 307
 None
 1.00A 1sbrA-3u1hA:
undetectable
1sbrB-3u1hA:
undetectable		 1sbrA-3u1hA:
17.86
1sbrB-3u1hA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF00180
(Iso_dh) 		4 PRO A 109
PHE A 307
LEU A 303
SER A 306
 None
 1.17A 1sbrA-3uduA:
undetectable
1sbrB-3uduA:
undetectable		 1sbrA-3uduA:
18.46
1sbrB-3uduA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF02569
(Pantoate_ligase) 		4 PRO A 106
PHE A 117
LEU A 113
ILE A 112
 None
 1.17A 1sbrA-3uk2A:
undetectable
1sbrB-3uk2A:
undetectable		 1sbrA-3uk2A:
21.66
1sbrB-3uk2A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137

(Staphylococcus
aureus) 		PF13379
(NMT1_2) 		4 PRO A 143
HIS A 149
ILE A  44
SER A  91
 ZN  A 326 ( 4.7A)
ZN  A 326 ( 4.6A)
ZN  A 326 ( 4.5A)
None
 1.18A 1sbrA-3un6A:
undetectable
1sbrB-3un6A:
undetectable		 1sbrA-3un6A:
21.31
1sbrB-3un6A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 PRO A 579
LEU A 153
ILE A 150
SER A 141
 None
 1.11A 1sbrA-4a2qA:
undetectable
1sbrB-4a2qA:
undetectable		 1sbrA-4a2qA:
14.38
1sbrB-4a2qA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 PRO A 579
LEU A 153
ILE A 150
SER A 141
 None
 1.10A 1sbrA-4a2wA:
undetectable
1sbrB-4a2wA:
undetectable		 1sbrA-4a2wA:
11.83
1sbrB-4a2wA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		4 HIS A 548
PHE A 468
LEU A 529
ILE A 525
 None
 1.23A 1sbrA-4anjA:
undetectable
1sbrB-4anjA:
undetectable		 1sbrA-4anjA:
11.14
1sbrB-4anjA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 4 HIS A 306
LEU A 404
ILE A 457
SER A 432
 None
 1.21A 1sbrA-4aw7A:
undetectable
1sbrB-4aw7A:
undetectable		 1sbrA-4aw7A:
15.70
1sbrB-4aw7A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		4 PRO A 464
PHE A  71
LEU A  67
ILE A  66
 None
 1.14A 1sbrA-4ccdA:
undetectable
1sbrB-4ccdA:
undetectable		 1sbrA-4ccdA:
13.68
1sbrB-4ccdA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2s UREIDOGLYCINE
AMINOHYDROLASE

(Arabidopsis
thaliana) 		PF07883
(Cupin_2) 		4 HIS A 159
PHE A 172
LEU A 125
ILE A 126
 None
 1.09A 1sbrA-4e2sA:
undetectable
1sbrB-4e2sA:
undetectable		 1sbrA-4e2sA:
22.43
1sbrB-4e2sA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 PHE A 263
LEU A 317
ILE A 321
SER A 259
 None
 1.22A 1sbrA-4f4cA:
undetectable
1sbrB-4f4cA:
undetectable		 1sbrA-4f4cA:
9.19
1sbrB-4f4cA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6w N-TERMINAL
CYANOBACTIN PROTEASE

(Planktothrix
agardhii) 		PF00082
(Peptidase_S8) 		4 PRO A 201
LEU A 280
ILE A 279
SER A 257
 None
 1.12A 1sbrA-4h6wA:
undetectable
1sbrB-4h6wA:
undetectable		 1sbrA-4h6wA:
23.45
1sbrB-4h6wA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PRO A 360
HIS A 323
LEU A  38
ILE A 367
 None
 1.13A 1sbrA-4j3zA:
undetectable
1sbrB-4j3zA:
undetectable		 1sbrA-4j3zA:
18.44
1sbrB-4j3zA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		4 PHE A 151
LEU A 107
ILE A 110
SER A 147
 None
 0.89A 1sbrA-4lz6A:
undetectable
1sbrB-4lz6A:
undetectable		 1sbrA-4lz6A:
17.71
1sbrB-4lz6A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		4 PRO A 147
LEU A 180
ILE A 181
SER A 176
 None
 1.11A 1sbrA-4mhcA:
undetectable
1sbrB-4mhcA:
undetectable		 1sbrA-4mhcA:
13.72
1sbrB-4mhcA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o94 TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		4 PRO A  90
PHE A 120
LEU A 129
ILE A 102
 None
 1.16A 1sbrA-4o94A:
undetectable
1sbrB-4o94A:
undetectable		 1sbrA-4o94A:
20.83
1sbrB-4o94A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		4 PRO E 442
PHE U 246
ILE U 361
SER U 247
 None
 1.19A 1sbrA-4oztE:
undetectable
1sbrB-4oztE:
undetectable		 1sbrA-4oztE:
21.90
1sbrB-4oztE:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST

(Escherichia
coli) 		PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N) 		4 PRO A 175
HIS A 138
ILE A 212
SER A 254
 None
 1.10A 1sbrA-4p05A:
undetectable
1sbrB-4p05A:
undetectable		 1sbrA-4p05A:
16.40
1sbrB-4p05A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1i AMINOBENZOYL-GLUTAMA
TE TRANSPORTER

(Neisseria
gonorrhoeae) 		PF03806
(ABG_transport) 		4 PRO A  95
LEU A 356
ILE A 360
SER A 415
 None
 1.18A 1sbrA-4r1iA:
undetectable
1sbrB-4r1iA:
undetectable		 1sbrA-4r1iA:
17.67
1sbrB-4r1iA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS

(Mycoplasma
pneumoniae) 		PF02917
(Pertussis_S1) 		4 PRO A 210
PHE A 228
ILE A  37
SER A 227
 None
 1.15A 1sbrA-4tlvA:
undetectable
1sbrB-4tlvA:
undetectable		 1sbrA-4tlvA:
15.36
1sbrB-4tlvA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens) 		PF03283
(PAE) 		4 PRO A 384
PHE A 123
ILE A 391
SER A 231
 None
 1.18A 1sbrA-4uz1A:
undetectable
1sbrB-4uz1A:
undetectable		 1sbrA-4uz1A:
19.73
1sbrB-4uz1A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		4 PHE A   6
LEU A 125
ILE A 133
SER A 167
 None
 0.94A 1sbrA-4w8xA:
2.3
1sbrB-4w8xA:
undetectable		 1sbrA-4w8xA:
18.50
1sbrB-4w8xA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbh PROTEIN NOTUM
HOMOLOG

(Homo sapiens) 		PF03283
(PAE) 		4 PRO A 384
PHE A 123
ILE A 391
SER A 231
 None
 1.17A 1sbrA-4wbhA:
undetectable
1sbrB-4wbhA:
undetectable		 1sbrA-4wbhA:
17.41
1sbrB-4wbhA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B

(Roseobacter
denitrificans) 		PF00115
(COX1) 		4 HIS A 194
PHE A 237
LEU A 236
ILE A 240
 FE  A 505 (-2.9A)
None
None
None
 1.22A 1sbrA-4xydA:
undetectable
1sbrB-4xydA:
undetectable		 1sbrA-4xydA:
16.48
1sbrB-4xydA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans) 		no annotation 4 PRO A 341
HIS A 178
LEU A 125
ILE A 171
 None
 1.14A 1sbrA-5ah0A:
undetectable
1sbrB-5ah0A:
undetectable		 1sbrA-5ah0A:
17.69
1sbrB-5ah0A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 4 PHE A  99
LEU A  98
ILE A 319
SER A 361
 None
 1.00A 1sbrA-5b2oA:
undetectable
1sbrB-5b2oA:
undetectable		 1sbrA-5b2oA:
8.08
1sbrB-5b2oA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqq TWO PORE CALCIUM
CHANNEL PROTEIN 1

(Arabidopsis
thaliana) 		PF00520
(Ion_trans) 		4 PHE A 137
LEU A  70
ILE A  66
SER A 140
 None
 1.23A 1sbrA-5dqqA:
undetectable
1sbrB-5dqqA:
undetectable		 1sbrA-5dqqA:
14.47
1sbrB-5dqqA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PRO A  79
HIS A  64
PHE A 439
LEU A 399
 None
CU  A 509 (-3.2A)
None
None
 1.04A 1sbrA-5ehfA:
undetectable
1sbrB-5ehfA:
undetectable		 1sbrA-5ehfA:
16.97
1sbrB-5ehfA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh9 PVDN

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		4 PRO A 358
PHE A 169
ILE A 183
SER A 144
 None
 1.17A 1sbrA-5hh9A:
undetectable
1sbrB-5hh9A:
undetectable		 1sbrA-5hh9A:
17.86
1sbrB-5hh9A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE

(Streptomyces
sp. MJ635-86F5) 		PF00501
(AMP-binding) 		4 PHE A 310
LEU A 200
ILE A 201
SER A 284
 None
 1.10A 1sbrA-5jjpA:
undetectable
1sbrB-5jjpA:
undetectable		 1sbrA-5jjpA:
17.16
1sbrB-5jjpA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		4 PRO A 554
PHE A 561
LEU A 458
ILE A 475
 None
 1.20A 1sbrA-5jseA:
undetectable
1sbrB-5jseA:
undetectable		 1sbrA-5jseA:
14.67
1sbrB-5jseA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE

(Shewanella
oneidensis) 		PF00465
(Fe-ADH) 		4 HIS A  45
LEU A  22
ILE A 138
SER A  18
 NAD  A 401 (-4.6A)
None
None
None
 1.18A 1sbrA-5k8cA:
undetectable
1sbrB-5k8cA:
undetectable		 1sbrA-5k8cA:
20.00
1sbrB-5k8cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 PRO A 595
LEU A 654
ILE A 658
SER A 569
 None
 1.20A 1sbrA-5kf7A:
undetectable
1sbrB-5kf7A:
undetectable		 1sbrA-5kf7A:
9.64
1sbrB-5kf7A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 PRO A 842
HIS A 767
LEU A 775
ILE A 844
 None
 1.20A 1sbrA-5lcwA:
undetectable
1sbrB-5lcwA:
undetectable		 1sbrA-5lcwA:
6.13
1sbrB-5lcwA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN

(Mus musculus) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		4 PRO A 162
PHE A  61
LEU A 111
ILE A 137
 None
 1.15A 1sbrA-5lfrA:
undetectable
1sbrB-5lfrA:
undetectable		 1sbrA-5lfrA:
19.75
1sbrB-5lfrA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ted LMO0488 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 PRO B 217
LEU B 205
ILE B 206
SER B 200
 None
None
None
SKM  B 401 (-2.8A)
 1.11A 1sbrA-5tedB:
undetectable
1sbrB-5tedB:
undetectable		 1sbrA-5tedB:
18.53
1sbrB-5tedB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 4 HIS A  90
PHE A 199
LEU A 100
ILE A  66
 None
 1.23A 1sbrA-5utiA:
undetectable
1sbrB-5utiA:
undetectable		 1sbrA-5utiA:
22.16
1sbrB-5utiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 4 PRO C 556
PHE C 545
LEU C 544
ILE C 591
 None
 1.02A 1sbrA-5x6oC:
undetectable
1sbrB-5x6oC:
undetectable		 1sbrA-5x6oC:
17.10
1sbrB-5x6oC:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcb PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 4 PRO A 178
PHE A 249
ILE A 210
SER A 244
 None
 1.19A 1sbrA-5xcbA:
2.7
1sbrB-5xcbA:
2.8		 1sbrA-5xcbA:
17.09
1sbrB-5xcbA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y96 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR1

(Arabidopsis
thaliana) 		no annotation 4 PRO B 352
PHE B 190
LEU B 189
ILE B 269
 None
 1.08A 1sbrA-5y96B:
undetectable
1sbrB-5y96B:
undetectable		 1sbrA-5y96B:
17.44
1sbrB-5y96B:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yje PROTEIN HIRA

(Homo sapiens) 		no annotation 4 PRO A 686
PHE A 760
ILE A 738
SER A 758
 None
 1.14A 1sbrA-5yjeA:
undetectable
1sbrB-5yjeA:
undetectable		 1sbrA-5yjeA:
16.58
1sbrB-5yjeA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 4 PRO 4 409
PHE 4 342
LEU 4 350
ILE 4 543
 None
 1.21A 1sbrA-5zvs4:
undetectable
1sbrB-5zvs4:
undetectable		 1sbrA-5zvs4:
19.50
1sbrB-5zvs4:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 PRO A1878
LEU A2175
ILE A2167
SER A1951
 None
 1.19A 1sbrA-6emkA:
undetectable
1sbrB-6emkA:
undetectable		 1sbrA-6emkA:
21.02
1sbrB-6emkA:
21.02