SIMILAR PATTERNS OF AMINO ACIDS FOR 1SBR_A_VIBA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE


(Homo sapiens)
PF00494
(SQS_PSY)
5 PHE A 210
ALA A 266
LEU A 267
ILE A 263
CYH A 258
None
1.38A 1sbrA-1ezfA:
0.2
1sbrB-1ezfA:
0.5
1sbrA-1ezfA:
22.38
1sbrB-1ezfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747


(Methanothermobacter
thermautotrophicus)
PF03807
(F420_oxidored)
PF09130
(DUF1932)
4 ALA A  16
LEU A  15
ILE A  61
CYH A  57
None
1.05A 1sbrA-1i36A:
0.0
1sbrB-1i36A:
0.0
1sbrA-1i36A:
22.01
1sbrB-1i36A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1


(Solanum
lycopersicum)
PF00724
(Oxidored_FMN)
4 PHE A 219
ALA A 220
ILE A 186
CYH A 273
None
0.97A 1sbrA-1icpA:
0.0
1sbrB-1icpA:
0.0
1sbrA-1icpA:
20.70
1sbrB-1icpA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipg BEM1 PROTEIN

(Saccharomyces
cerevisiae)
PF00564
(PB1)
4 PHE A  24
ALA A  25
LEU A  26
ILE A  15
None
0.89A 1sbrA-1ipgA:
0.0
1sbrB-1ipgA:
0.0
1sbrA-1ipgA:
15.62
1sbrB-1ipgA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE


(Methanocaldococcus
jannaschii)
PF00579
(tRNA-synt_1b)
4 ALA A 292
LEU A 295
ILE A 244
CYH A 231
None
None
None
U  B 536 ( 4.3A)
1.08A 1sbrA-1j1uA:
0.0
1sbrB-1j1uA:
0.0
1sbrA-1j1uA:
21.77
1sbrB-1j1uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA


(Mycobacterium
tuberculosis)
PF01625
(PMSR)
4 ALA A  10
LEU A   9
ILE A  96
SER A  94
None
1.03A 1sbrA-1nwaA:
0.3
1sbrB-1nwaA:
0.7
1sbrA-1nwaA:
20.17
1sbrB-1nwaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7x CITRATE SYNTHASE

(Sulfolobus
solfataricus)
PF00285
(Citrate_synt)
4 ALA A 176
LEU A 179
ILE A 178
SER A 337
None
1.05A 1sbrA-1o7xA:
1.3
1sbrB-1o7xA:
1.1
1sbrA-1o7xA:
19.13
1sbrB-1o7xA:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s7h YKOF

(Bacillus
subtilis)
PF07615
(Ykof)
5 PHE A 119
ALA A 120
LEU A 121
ILE A 133
SER A 154
None
0.38A 1sbrA-1s7hA:
33.9
1sbrB-1s7hA:
33.9
1sbrA-1s7hA:
99.00
1sbrB-1s7hA:
99.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE


(Pyrococcus
furiosus)
PF04587
(ADP_PFK_GK)
4 PHE A 364
ALA A 365
LEU A 367
SER A 445
None
1.05A 1sbrA-1ua4A:
0.0
1sbrB-1ua4A:
0.0
1sbrA-1ua4A:
20.29
1sbrB-1ua4A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7l 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT


(Pyrococcus
horikoshii)
PF00694
(Aconitase_C)
4 ALA A  71
LEU A  74
ILE A  19
SER A  69
None
1.05A 1sbrA-1v7lA:
undetectable
1sbrB-1v7lA:
undetectable
1sbrA-1v7lA:
20.64
1sbrB-1v7lA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcm CALPAIN 1, LARGE
[CATALYTIC] SUBUNIT


(Homo sapiens)
PF00648
(Peptidase_C2)
4 ALA A 120
LEU A 118
ILE A 107
SER A 275
None
1.02A 1sbrA-1zcmA:
undetectable
1sbrB-1zcmA:
undetectable
1sbrA-1zcmA:
22.92
1sbrB-1zcmA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN


(Thermus
aquaticus)
no annotation 4 PHE D 251
ALA D 305
LEU D 304
ILE D 270
None
1.00A 1sbrA-2aujD:
undetectable
1sbrB-2aujD:
undetectable
1sbrA-2aujD:
20.97
1sbrB-2aujD:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bht CYSTEINE SYNTHASE B

(Escherichia
coli)
PF00291
(PALP)
4 PHE A 169
ALA A 277
SER A 171
CYH A 252
None
1.03A 1sbrA-2bhtA:
undetectable
1sbrB-2bhtA:
undetectable
1sbrA-2bhtA:
20.58
1sbrB-2bhtA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE


(Archaeoglobus
fulgidus)
PF00579
(tRNA-synt_1b)
4 ALA A 305
LEU A 308
ILE A 254
CYH A 241
None
1.01A 1sbrA-2cybA:
undetectable
1sbrB-2cybA:
undetectable
1sbrA-2cybA:
20.61
1sbrB-2cybA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fus FUMARASE C

(Escherichia
coli)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
4 PHE A 258
ALA A 251
LEU A 250
ILE A 253
None
1.06A 1sbrA-2fusA:
undetectable
1sbrB-2fusA:
undetectable
1sbrA-2fusA:
18.59
1sbrB-2fusA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT


(Streptococcus
mutans)
PF04223
(CitF)
4 PHE A 304
ALA A 305
LEU A 306
SER A 275
None
0.86A 1sbrA-2hj0A:
undetectable
1sbrB-2hj0A:
undetectable
1sbrA-2hj0A:
17.94
1sbrB-2hj0A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3


(Brevibacillus
brevis)
PF00550
(PP-binding)
PF00668
(Condensation)
4 ALA A  15
LEU A  17
ILE A  72
SER A  11
None
1.07A 1sbrA-2jgpA:
undetectable
1sbrB-2jgpA:
1.5
1sbrA-2jgpA:
18.64
1sbrB-2jgpA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqa CALPAIN 8

(Homo sapiens)
PF00648
(Peptidase_C2)
4 ALA A 110
LEU A 108
ILE A  97
SER A 265
None
None
CSO  A  98 ( 4.0A)
None
1.06A 1sbrA-2nqaA:
undetectable
1sbrB-2nqaA:
undetectable
1sbrA-2nqaA:
20.80
1sbrB-2nqaA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE


(Shewanella
oneidensis)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
4 PHE A 264
ALA A 265
LEU A 266
ILE A 211
None
1.05A 1sbrA-2oasA:
undetectable
1sbrB-2oasA:
undetectable
1sbrA-2oasA:
19.63
1sbrB-2oasA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p97 HYPOTHETICAL PROTEIN

(Trichormus
variabilis)
PF14597
(Lactamase_B_5)
4 ALA A 175
LEU A 132
ILE A 133
SER A 183
None
0.98A 1sbrA-2p97A:
undetectable
1sbrB-2p97A:
undetectable
1sbrA-2p97A:
22.07
1sbrB-2p97A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum)
PF01979
(Amidohydro_1)
4 PHE A  14
ALA A  15
LEU A  16
ILE A  36
None
0.86A 1sbrA-2p9bA:
undetectable
1sbrB-2p9bA:
undetectable
1sbrA-2p9bA:
19.26
1sbrB-2p9bA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qya UNCHARACTERIZED
CONSERVED PROTEIN


(Methanopyrus
kandleri)
PF04242
(DUF424)
4 ALA A  18
LEU A  17
ILE A  72
CYH A  80
None
0.87A 1sbrA-2qyaA:
undetectable
1sbrB-2qyaA:
undetectable
1sbrA-2qyaA:
20.00
1sbrB-2qyaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum)
PF00285
(Citrate_synt)
4 ALA A 180
LEU A 183
ILE A 182
SER A 343
None
1.03A 1sbrA-2r26A:
undetectable
1sbrB-2r26A:
undetectable
1sbrA-2r26A:
17.97
1sbrB-2r26A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli)
PF00586
(AIRS)
PF02769
(AIRS_C)
4 ALA A 117
ILE A  77
SER A 115
CYH A  96
None
1.00A 1sbrA-2rb9A:
undetectable
1sbrB-2rb9A:
1.8
1sbrA-2rb9A:
21.84
1sbrB-2rb9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpv PROTEIN MIF2

(Saccharomyces
cerevisiae)
PF11699
(CENP-C_C)
4 PHE A 439
ALA A 440
LEU A 441
SER A 469
None
1.06A 1sbrA-2vpvA:
undetectable
1sbrB-2vpvA:
undetectable
1sbrA-2vpvA:
17.50
1sbrB-2vpvA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvh TRANSCRIPTIONAL
REGULATOR


(Corynebacterium
glutamicum)
PF00440
(TetR_N)
4 PHE A 109
ALA A 103
LEU A  99
SER A 105
None
0.99A 1sbrA-2yvhA:
undetectable
1sbrB-2yvhA:
undetectable
1sbrA-2yvhA:
23.87
1sbrB-2yvhA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy6 PHOSPHOGLYCOLATE
PHOSPHATASE


(Aquifex
aeolicus)
PF13419
(HAD_2)
4 PHE A 124
ALA A 101
LEU A 100
ILE A   4
None
0.99A 1sbrA-2yy6A:
undetectable
1sbrB-2yy6A:
undetectable
1sbrA-2yy6A:
21.93
1sbrB-2yy6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X


(Streptococcus
pneumoniae)
PF00905
(Transpeptidase)
4 ALA B 508
LEU B 510
ILE B 348
SER B 504
None
1.06A 1sbrA-2z2mB:
undetectable
1sbrB-2z2mB:
undetectable
1sbrA-2z2mB:
21.71
1sbrB-2z2mB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE


(Escherichia
coli)
PF02798
(GST_N)
PF13410
(GST_C_2)
4 ALA A 103
LEU A 104
ILE A 121
SER A  49
None
0.92A 1sbrA-3c8eA:
undetectable
1sbrB-3c8eA:
undetectable
1sbrA-3c8eA:
21.92
1sbrB-3c8eA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT


(Candida
albicans)
PF00432
(Prenyltrans)
4 ALA B  33
LEU B  32
ILE B  35
CYH B  16
None
1.01A 1sbrA-3draB:
undetectable
1sbrB-3draB:
undetectable
1sbrA-3draB:
16.93
1sbrB-3draB:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egl DEGV FAMILY PROTEIN

(Corynebacterium
glutamicum)
PF02645
(DegV)
4 ALA A  11
LEU A  99
ILE A  68
SER A   9
None
PLM  A 275 ( 4.6A)
None
None
1.07A 1sbrA-3eglA:
undetectable
1sbrB-3eglA:
undetectable
1sbrA-3eglA:
22.46
1sbrB-3eglA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis)
PF02645
(DegV)
4 ALA A 122
LEU A 121
ILE A 232
SER A 119
None
None
PLM  A 501 (-4.0A)
PLM  A 501 ( 4.7A)
0.94A 1sbrA-3fysA:
undetectable
1sbrB-3fysA:
undetectable
1sbrA-3fysA:
20.39
1sbrB-3fysA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE


(Methanosarcina
mazei)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
4 PHE A 174
ALA A 175
LEU A 176
ILE A 202
None
0.94A 1sbrA-3g79A:
undetectable
1sbrB-3g79A:
undetectable
1sbrA-3g79A:
17.34
1sbrB-3g79A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7k 3-METHYLITACONATE
ISOMERASE


(Eubacterium
barkeri)
PF04303
(PrpF)
4 PHE A  42
ALA A  54
LEU A  53
ILE A  11
None
1.07A 1sbrA-3g7kA:
undetectable
1sbrB-3g7kA:
undetectable
1sbrA-3g7kA:
21.43
1sbrB-3g7kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN


(Staphylococcus
haemolyticus)
PF13377
(Peripla_BP_3)
4 ALA A 130
LEU A 133
ILE A 205
CYH A 177
None
1.07A 1sbrA-3huuA:
undetectable
1sbrB-3huuA:
undetectable
1sbrA-3huuA:
19.68
1sbrB-3huuA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ila RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus)
PF08709
(Ins145_P3_rec)
4 PHE A 133
ALA A 132
LEU A 131
SER A 124
None
0.94A 1sbrA-3ilaA:
undetectable
1sbrB-3ilaA:
undetectable
1sbrA-3ilaA:
19.64
1sbrB-3ilaA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kty PROBABLE
METHYLTRANSFERASE


(Bordetella
pertussis)
PF00588
(SpoU_methylase)
4 ALA A 161
LEU A 160
ILE A 143
CYH A  97
None
1.02A 1sbrA-3ktyA:
undetectable
1sbrB-3ktyA:
undetectable
1sbrA-3ktyA:
24.37
1sbrB-3ktyA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lu2 LMO2462 PROTEIN

(Listeria
monocytogenes)
PF01244
(Peptidase_M19)
4 ALA A 195
LEU A 205
ILE A 220
CYH A 248
None
0.89A 1sbrA-3lu2A:
undetectable
1sbrB-3lu2A:
undetectable
1sbrA-3lu2A:
20.06
1sbrB-3lu2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis)
PF00120
(Gln-synt_C)
PF12437
(GSIII_N)
4 ALA A 548
LEU A 552
ILE A 408
CYH A 556
None
0.99A 1sbrA-3o6xA:
2.9
1sbrB-3o6xA:
0.9
1sbrA-3o6xA:
13.36
1sbrB-3o6xA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oib ACYL-COA
DEHYDROGENASE


(Mycolicibacterium
smegmatis)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
4 ALA A 108
LEU A 110
ILE A  58
SER A 181
None
1.07A 1sbrA-3oibA:
undetectable
1sbrB-3oibA:
undetectable
1sbrA-3oibA:
20.20
1sbrB-3oibA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7h ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT


(Coxiella
burnetii)
PF00574
(CLP_protease)
4 ALA A 102
LEU A 104
ILE A  65
CYH A 115
None
0.98A 1sbrA-3q7hA:
undetectable
1sbrB-3q7hA:
undetectable
1sbrA-3q7hA:
22.07
1sbrB-3q7hA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3j GLUTAMATE
DEHYDROGENASE


(Plasmodium
falciparum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 PHE A 279
ALA A 280
ILE A 427
CYH A 402
None
0.93A 1sbrA-3r3jA:
undetectable
1sbrB-3r3jA:
undetectable
1sbrA-3r3jA:
17.03
1sbrB-3r3jA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg9 PENICILLIN-BINDING
PROTEIN


(Bacillus
halodurans)
PF00144
(Beta-lactamase)
4 ALA A  18
LEU A  19
SER A  31
CYH A 295
None
1.05A 1sbrA-3tg9A:
undetectable
1sbrB-3tg9A:
undetectable
1sbrA-3tg9A:
21.80
1sbrB-3tg9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqy SINGLE-STRANDED
DNA-BINDING PROTEIN


(Coxiella
burnetii)
PF00436
(SSB)
4 PHE A  62
ALA A  67
LEU A  66
ILE A  69
None
1.07A 1sbrA-3tqyA:
undetectable
1sbrB-3tqyA:
undetectable
1sbrA-3tqyA:
19.23
1sbrB-3tqyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans)
PF00221
(Lyase_aromatic)
4 ALA A 217
LEU A 216
ILE A 219
CYH A 181
None
1.07A 1sbrA-3unvA:
undetectable
1sbrB-3unvA:
undetectable
1sbrA-3unvA:
16.76
1sbrB-3unvA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arp PESTICIN

(Yersinia pestis)
PF16754
(Pesticin)
4 ALA A 256
LEU A 258
ILE A 225
SER A 252
None
0.99A 1sbrA-4arpA:
undetectable
1sbrB-4arpA:
undetectable
1sbrA-4arpA:
20.06
1sbrB-4arpA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 ALA A 173
LEU A 176
SER A 171
CYH A 416
None
0.97A 1sbrA-4c7vA:
undetectable
1sbrB-4c7vA:
undetectable
1sbrA-4c7vA:
15.84
1sbrB-4c7vA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG


(Homo sapiens)
PF02854
(MIF4G)
4 PHE B 296
ALA B 293
LEU B 297
ILE B 315
None
0.93A 1sbrA-4c9bB:
undetectable
1sbrB-4c9bB:
undetectable
1sbrA-4c9bB:
21.48
1sbrB-4c9bB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL20

(Sus scrofa)
PF00453
(Ribosomal_L20)
4 PHE U 113
ALA U 117
LEU U 116
SER U  76
None
1.04A 1sbrA-4ce4U:
undetectable
1sbrB-4ce4U:
undetectable
1sbrA-4ce4U:
17.07
1sbrB-4ce4U:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 ALA A 312
LEU A 311
ILE A 351
SER A 287
None
0.90A 1sbrA-4dzaA:
undetectable
1sbrB-4dzaA:
undetectable
1sbrA-4dzaA:
20.84
1sbrB-4dzaA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA


(Rhodococcus
rhodochrous)
PF00067
(p450)
4 ALA A 349
LEU A 352
ILE A 382
SER A 345
None
1.04A 1sbrA-4ep6A:
undetectable
1sbrB-4ep6A:
undetectable
1sbrA-4ep6A:
19.74
1sbrB-4ep6A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f53 SUSD HOMOLOG

(Bacteroides
ovatus)
PF12741
(SusD-like)
4 PHE A 216
ALA A 217
LEU A 220
ILE A 141
None
0.98A 1sbrA-4f53A:
undetectable
1sbrB-4f53A:
undetectable
1sbrA-4f53A:
17.07
1sbrB-4f53A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE


(Saccharomyces
cerevisiae)
PF07992
(Pyr_redox_2)
4 PHE A  68
ALA A  65
LEU A  69
ILE A  81
PHE  A  68 ( 1.3A)
ALA  A  65 ( 0.0A)
LEU  A  69 ( 0.6A)
ILE  A  81 ( 0.4A)
1.08A 1sbrA-4g9kA:
undetectable
1sbrB-4g9kA:
undetectable
1sbrA-4g9kA:
17.93
1sbrB-4g9kA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwb PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA 3


(Sinorhizobium
meliloti)
PF01625
(PMSR)
4 ALA A   8
LEU A   7
ILE A  94
SER A  92
None
1.06A 1sbrA-4gwbA:
undetectable
1sbrB-4gwbA:
undetectable
1sbrA-4gwbA:
21.96
1sbrB-4gwbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE


(Mycobacterium
tuberculosis)
PF00682
(HMGL-like)
PF07836
(DmpG_comm)
4 PHE A 124
ALA A 159
ILE A 155
SER A 120
None
1.08A 1sbrA-4jn6A:
undetectable
1sbrB-4jn6A:
undetectable
1sbrA-4jn6A:
21.37
1sbrB-4jn6A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Vibrio cholerae)
no annotation 4 ALA D 163
LEU D 344
ILE D 109
SER D 161
None
1.08A 1sbrA-4jrmD:
undetectable
1sbrB-4jrmD:
undetectable
1sbrA-4jrmD:
19.62
1sbrB-4jrmD:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0d PERIPLASMIC SENSOR
HYBRID HISTIDINE
KINASE


(Anaeromyxobacter
dehalogenans)
no annotation 4 PHE A  98
ALA A  99
LEU A 101
SER A 111
None
1.04A 1sbrA-4k0dA:
undetectable
1sbrB-4k0dA:
undetectable
1sbrA-4k0dA:
23.58
1sbrB-4k0dA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4i RYANODINE RECEPTOR 2

(Mus musculus)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec)
4 PHE A 145
ALA A 144
LEU A 143
SER A 136
None
0.98A 1sbrA-4l4iA:
undetectable
1sbrB-4l4iA:
undetectable
1sbrA-4l4iA:
16.27
1sbrB-4l4iA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]


(Synechocystis
sp. PCC 6803)
PF02347
(GDC-P)
4 ALA A 302
LEU A 359
ILE A 293
SER A 287
None
1.00A 1sbrA-4lglA:
undetectable
1sbrB-4lglA:
undetectable
1sbrA-4lglA:
12.50
1sbrB-4lglA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans)
PF01554
(MatE)
4 PHE A 151
LEU A 107
ILE A 110
SER A 147
None
0.91A 1sbrA-4lz6A:
undetectable
1sbrB-4lz6A:
undetectable
1sbrA-4lz6A:
17.71
1sbrB-4lz6A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE


(Escherichia
coli)
PF12697
(Abhydrolase_6)
4 LEU A  43
ILE A  77
SER A  41
CYH A 104
None
0.95A 1sbrA-4mydA:
undetectable
1sbrB-4mydA:
undetectable
1sbrA-4mydA:
19.71
1sbrB-4mydA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzw GLUTATHIONE
S-TRANSFERASE


(Streptococcus
sanguinis)
PF02798
(GST_N)
PF13410
(GST_C_2)
4 ALA A 100
LEU A 101
ILE A 118
SER A  46
None
0.95A 1sbrA-4mzwA:
undetectable
1sbrB-4mzwA:
undetectable
1sbrA-4mzwA:
21.58
1sbrB-4mzwA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF01425
(Amidase)
4 PHE A 145
ALA A 146
LEU A 147
ILE A  51
None
0.86A 1sbrA-4n0iA:
undetectable
1sbrB-4n0iA:
undetectable
1sbrA-4n0iA:
18.75
1sbrB-4n0iA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pua GLUTATHIONE
S-TRANSFERASE


(Streptococcus
pneumoniae)
PF02798
(GST_N)
PF13410
(GST_C_2)
4 ALA A 101
LEU A 102
ILE A 119
SER A  47
None
0.89A 1sbrA-4puaA:
undetectable
1sbrB-4puaA:
undetectable
1sbrA-4puaA:
22.76
1sbrB-4puaA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtb HYDG PROTEIN

(Carboxydothermus
hydrogenoformans)
PF04055
(Radical_SAM)
PF06968
(BATS)
4 PHE A  79
ALA A  80
LEU A 130
SER A 325
None
None
None
CL  A 507 (-4.7A)
1.05A 1sbrA-4rtbA:
undetectable
1sbrB-4rtbA:
undetectable
1sbrA-4rtbA:
17.11
1sbrB-4rtbA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Neisseria
meningitidis)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 ALA A 136
LEU A 137
ILE A  74
SER A 169
None
1.05A 1sbrA-4rybA:
undetectable
1sbrB-4rybA:
undetectable
1sbrA-4rybA:
24.53
1sbrB-4rybA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1


(Saccharomyces
cerevisiae)
PF01977
(UbiD)
4 PHE A 212
ALA A 213
LEU A 214
CYH A 124
None
0.88A 1sbrA-4s13A:
undetectable
1sbrB-4s13A:
undetectable
1sbrA-4s13A:
17.36
1sbrB-4s13A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpg PROTON:OLIGOPEPTIDE
SYMPORTER POT FAMILY


(Shewanella
oneidensis)
PF00854
(PTR2)
4 ALA A 109
LEU A 110
ILE A 113
CYH A 186
None
0.94A 1sbrA-4tpgA:
undetectable
1sbrB-4tpgA:
undetectable
1sbrA-4tpgA:
16.57
1sbrB-4tpgA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tq5 PRENYLTRANSFERASE

(Archaeoglobus
fulgidus)
PF01040
(UbiA)
4 ALA A  50
LEU A  52
ILE A 121
SER A  46
None
0.96A 1sbrA-4tq5A:
undetectable
1sbrB-4tq5A:
undetectable
1sbrA-4tq5A:
22.74
1sbrB-4tq5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uar PROTEIN CBBY

(Rhodobacter
sphaeroides)
PF13419
(HAD_2)
4 PHE A 138
ALA A 112
LEU A 111
ILE A   5
None
1.06A 1sbrA-4uarA:
undetectable
1sbrB-4uarA:
undetectable
1sbrA-4uarA:
20.43
1sbrB-4uarA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2


(Homo sapiens)
PF01661
(Macro)
4 ALA A 156
LEU A 155
ILE A 126
CYH A  68
None
1.06A 1sbrA-4umlA:
undetectable
1sbrB-4umlA:
undetectable
1sbrA-4umlA:
20.17
1sbrB-4umlA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus)
PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec)
4 PHE A 133
ALA A 132
LEU A 131
SER A 124
None
1.02A 1sbrA-4uwaA:
undetectable
1sbrB-4uwaA:
undetectable
1sbrA-4uwaA:
4.38
1sbrB-4uwaA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1


(Pyrococcus
furiosus)
PF03787
(RAMPs)
4 PHE A   6
LEU A 125
ILE A 133
SER A 167
None
1.00A 1sbrA-4w8xA:
2.3
1sbrB-4w8xA:
undetectable
1sbrA-4w8xA:
18.50
1sbrB-4w8xA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB


(Lactococcus
lactis)
PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C)
4 PHE A1011
ILE A 179
SER A 210
CYH A 184
None
0.99A 1sbrA-4wd9A:
undetectable
1sbrB-4wd9A:
undetectable
1sbrA-4wd9A:
10.29
1sbrB-4wd9A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztc AMINOTRANSFERASE
HOMOLOG


(Campylobacter
jejuni)
PF01041
(DegT_DnrJ_EryC1)
4 ALA A  77
LEU A  76
SER A  79
CYH A  90
None
0.98A 1sbrA-4ztcA:
undetectable
1sbrB-4ztcA:
undetectable
1sbrA-4ztcA:
20.97
1sbrB-4ztcA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9


(Francisella
tularensis)
no annotation 4 PHE A  99
LEU A  98
ILE A 319
SER A 361
None
0.99A 1sbrA-5b2oA:
undetectable
1sbrB-5b2oA:
undetectable
1sbrA-5b2oA:
8.08
1sbrB-5b2oA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE


(Plasmodium
falciparum)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
4 PHE D  40
ALA D  41
ILE D  35
SER D  37
None
0.94A 1sbrA-5fmgD:
undetectable
1sbrB-5fmgD:
undetectable
1sbrA-5fmgD:
21.66
1sbrB-5fmgD:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxf ACRYLYL-COA
REDUCTASE ACUI


(Ruegeria
pomeroyi)
PF00107
(ADH_zinc_N)
4 ALA A 134
LEU A 136
ILE A 270
CYH A 220
None
1.04A 1sbrA-5gxfA:
undetectable
1sbrB-5gxfA:
undetectable
1sbrA-5gxfA:
18.98
1sbrB-5gxfA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri)
PF13412
(HTH_24)
PF14520
(HHH_5)
4 PHE A 576
ALA A 581
LEU A 584
ILE A 594
None
1.04A 1sbrA-5hm5A:
undetectable
1sbrB-5hm5A:
undetectable
1sbrA-5hm5A:
12.88
1sbrB-5hm5A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqw PUTATIVE POLYKETIDE
SYNTHASE


(Brevibacillus
brevis)
PF14765
(PS-DH)
4 ALA A2425
LEU A2423
ILE A2478
CYH A2481
None
0.99A 1sbrA-5hqwA:
undetectable
1sbrB-5hqwA:
undetectable
1sbrA-5hqwA:
20.47
1sbrB-5hqwA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF08326
(ACC_central)
4 ALA A1361
LEU A1364
ILE A1342
SER A1359
None
1.08A 1sbrA-5i6eA:
undetectable
1sbrB-5i6eA:
undetectable
1sbrA-5i6eA:
14.14
1sbrB-5i6eA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I


(Geobacillus
stearothermophilus)
PF01654
(Cyt_bd_oxida_I)
4 PHE A 197
ALA A 366
LEU A 365
ILE A 328
None
1.05A 1sbrA-5ir6A:
undetectable
1sbrB-5ir6A:
undetectable
1sbrA-5ir6A:
19.65
1sbrB-5ir6A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD


(Pseudomonas
aeruginosa)
PF04453
(OstA_C)
4 PHE A 572
ALA A 557
LEU A 556
ILE A 546
None
C8E  A 701 ( 4.1A)
None
None
1.06A 1sbrA-5ivaA:
undetectable
1sbrB-5ivaA:
undetectable
1sbrA-5ivaA:
14.26
1sbrB-5ivaA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j32 3-ISOPROPYLMALATE
DEHYDROGENASE 2,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00180
(Iso_dh)
4 ALA A 337
LEU A 340
ILE A 339
CYH A 386
None
0.95A 1sbrA-5j32A:
undetectable
1sbrB-5j32A:
undetectable
1sbrA-5j32A:
19.85
1sbrB-5j32A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE


(Paraburkholderia
xenovorans)
PF00155
(Aminotran_1_2)
4 ALA A 115
LEU A 117
ILE A 269
SER A 110
None
1.00A 1sbrA-5jayA:
undetectable
1sbrB-5jayA:
undetectable
1sbrA-5jayA:
19.80
1sbrB-5jayA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
4 PHE A 602
ALA A 555
LEU A 554
ILE A 563
None
1.02A 1sbrA-5k6oA:
undetectable
1sbrB-5k6oA:
undetectable
1sbrA-5k6oA:
12.13
1sbrB-5k6oA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l20 CLOSTRIPAIN-RELATED
PROTEIN


(Bacteroides
thetaiotaomicron)
PF03415
(Peptidase_C11)
no annotation
4 ALA B 380
LEU B 379
ILE A 146
SER B 372
None
1.08A 1sbrA-5l20B:
undetectable
1sbrB-5l20B:
undetectable
1sbrA-5l20B:
24.78
1sbrB-5l20B:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE


(Pseudomonas
protegens)
no annotation 4 ALA A  77
LEU A  78
ILE A  75
SER A 136
None
1.08A 1sbrA-5mg5A:
undetectable
1sbrB-5mg5A:
undetectable
1sbrA-5mg5A:
20.11
1sbrB-5mg5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyk THIOREDOXIN-LIKE
PROTEIN 2.1


(Populus tremula
x Populus
tremuloides)
no annotation 4 ALA A  56
LEU A  55
SER A   7
CYH A  67
None
0.87A 1sbrA-5nykA:
undetectable
1sbrB-5nykA:
undetectable
1sbrA-5nykA:
18.02
1sbrB-5nykA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6b ATP-DEPENDENT DNA
HELICASE PIF1


(Saccharomyces
cerevisiae)
no annotation 4 ALA A 248
LEU A 247
ILE A 244
CYH A 376
None
1.06A 1sbrA-5o6bA:
undetectable
1sbrB-5o6bA:
undetectable
1sbrA-5o6bA:
21.94
1sbrB-5o6bA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okz EXOSOME COMPLEX
COMPONENT MTR3


(Saccharomyces
cerevisiae)
PF01138
(RNase_PH)
4 ALA F  60
LEU F  61
ILE F  74
SER F 175
None
1.03A 1sbrA-5okzF:
undetectable
1sbrB-5okzF:
undetectable
1sbrA-5okzF:
23.02
1sbrB-5okzF:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1q N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
DOMAIN-CONTAINING
PROTEIN
SAOUHSC_02979


(Staphylococcus
aureus)
PF01832
(Glucosaminidase)
PF05257
(CHAP)
4 ALA A 349
LEU A 351
ILE A 462
SER A 355
None
0.99A 1sbrA-5t1qA:
undetectable
1sbrB-5t1qA:
undetectable
1sbrA-5t1qA:
20.56
1sbrB-5t1qA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE


(Mycolicibacterium
smegmatis)
no annotation 4 ALA A 847
LEU A 849
ILE A 679
SER A 843
None
1.02A 1sbrA-5v9xA:
undetectable
1sbrB-5v9xA:
undetectable
1sbrA-5v9xA:
15.50
1sbrB-5v9xA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 CAPSID VERTEX
PROTEIN GP24


(Escherichia
virus T4)
PF07068
(Gp23)
4 PHE a 197
ALA a 194
LEU a 198
ILE a 179
None
1.03A 1sbrA-5vf3a:
undetectable
1sbrB-5vf3a:
undetectable
1sbrA-5vf3a:
18.07
1sbrB-5vf3a:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vg9 PROTEIN-S-ISOPRENYLC
YSTEINE
O-METHYLTRANSFERASE


(Tribolium
castaneum)
no annotation 4 PHE A  13
ALA A  69
LEU A  71
SER A  17
None
1.05A 1sbrA-5vg9A:
undetectable
1sbrB-5vg9A:
undetectable
1sbrA-5vg9A:
17.02
1sbrB-5vg9A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9v RYANODINE RECEPTOR 1

(Plutella
xylostella)
no annotation 4 PHE A 129
ALA A 128
LEU A 127
SER A 121
None
0.79A 1sbrA-5y9vA:
undetectable
1sbrB-5y9vA:
undetectable
1sbrA-5y9vA:
17.10
1sbrB-5y9vA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdt CALPAIN-3

(Homo sapiens)
no annotation 4 ALA A 134
LEU A 132
ILE A 121
SER A 337
None
1.05A 1sbrA-6bdtA:
undetectable
1sbrB-6bdtA:
undetectable
1sbrA-6bdtA:
15.00
1sbrB-6bdtA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM


(Saccharomyces
cerevisiae)
no annotation 4 ALA A 641
LEU A 642
ILE A 645
CYH A 726
None
0.95A 1sbrA-6c6lA:
undetectable
1sbrB-6c6lA:
undetectable
1sbrA-6c6lA:
17.00
1sbrB-6c6lA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2


(Saccharomyces
cerevisiae)
no annotation 4 ALA A1841
LEU A1842
ILE A2356
SER A1837
None
0.94A 1sbrA-6emkA:
undetectable
1sbrB-6emkA:
undetectable
1sbrA-6emkA:
21.02
1sbrB-6emkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2


(Cyanidioschyzon
merolae)
no annotation 4 ALA B 232
LEU B 253
ILE B 252
SER B 234
None
0.90A 1sbrA-6fosB:
undetectable
1sbrB-6fosB:
undetectable
1sbrA-6fosB:
17.74
1sbrB-6fosB:
17.74