SIMILAR PATTERNS OF AMINO ACIDS FOR 1SBR_A_VIBA502_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ezf | FARNESYL-DIPHOSPHATEFARNESYLTRANSFERASE (Homo sapiens) |
PF00494(SQS_PSY) | 5 | PHE A 210ALA A 266LEU A 267ILE A 263CYH A 258 | None | 1.38A | 1sbrA-1ezfA:0.21sbrB-1ezfA:0.5 | 1sbrA-1ezfA:22.381sbrB-1ezfA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i36 | CONSERVEDHYPOTHETICAL PROTEINMTH1747 (Methanothermobacterthermautotrophicus) |
PF03807(F420_oxidored)PF09130(DUF1932) | 4 | ALA A 16LEU A 15ILE A 61CYH A 57 | None | 1.05A | 1sbrA-1i36A:0.01sbrB-1i36A:0.0 | 1sbrA-1i36A:22.011sbrB-1i36A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1icp | 12-OXOPHYTODIENOATEREDUCTASE 1 (Solanumlycopersicum) |
PF00724(Oxidored_FMN) | 4 | PHE A 219ALA A 220ILE A 186CYH A 273 | None | 0.97A | 1sbrA-1icpA:0.01sbrB-1icpA:0.0 | 1sbrA-1icpA:20.701sbrB-1icpA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ipg | BEM1 PROTEIN (Saccharomycescerevisiae) |
PF00564(PB1) | 4 | PHE A 24ALA A 25LEU A 26ILE A 15 | None | 0.89A | 1sbrA-1ipgA:0.01sbrB-1ipgA:0.0 | 1sbrA-1ipgA:15.621sbrB-1ipgA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j1u | TYROSYL-TRNASYNTHETASE (Methanocaldococcusjannaschii) |
PF00579(tRNA-synt_1b) | 4 | ALA A 292LEU A 295ILE A 244CYH A 231 | NoneNoneNone U B 536 ( 4.3A) | 1.08A | 1sbrA-1j1uA:0.01sbrB-1j1uA:0.0 | 1sbrA-1j1uA:21.771sbrB-1j1uA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nwa | PEPTIDE METHIONINESULFOXIDE REDUCTASEMSRA (Mycobacteriumtuberculosis) |
PF01625(PMSR) | 4 | ALA A 10LEU A 9ILE A 96SER A 94 | None | 1.03A | 1sbrA-1nwaA:0.31sbrB-1nwaA:0.7 | 1sbrA-1nwaA:20.171sbrB-1nwaA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o7x | CITRATE SYNTHASE (Sulfolobussolfataricus) |
PF00285(Citrate_synt) | 4 | ALA A 176LEU A 179ILE A 178SER A 337 | None | 1.05A | 1sbrA-1o7xA:1.31sbrB-1o7xA:1.1 | 1sbrA-1o7xA:19.131sbrB-1o7xA:19.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1s7h | YKOF (Bacillussubtilis) |
PF07615(Ykof) | 5 | PHE A 119ALA A 120LEU A 121ILE A 133SER A 154 | None | 0.38A | 1sbrA-1s7hA:33.91sbrB-1s7hA:33.9 | 1sbrA-1s7hA:99.001sbrB-1s7hA:99.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ua4 | ADP-DEPENDENTGLUCOKINASE (Pyrococcusfuriosus) |
PF04587(ADP_PFK_GK) | 4 | PHE A 364ALA A 365LEU A 367SER A 445 | None | 1.05A | 1sbrA-1ua4A:0.01sbrB-1ua4A:0.0 | 1sbrA-1ua4A:20.291sbrB-1ua4A:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v7l | 3-ISOPROPYLMALATEDEHYDRATASE SMALLSUBUNIT (Pyrococcushorikoshii) |
PF00694(Aconitase_C) | 4 | ALA A 71LEU A 74ILE A 19SER A 69 | None | 1.05A | 1sbrA-1v7lA:undetectable1sbrB-1v7lA:undetectable | 1sbrA-1v7lA:20.641sbrB-1v7lA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zcm | CALPAIN 1, LARGE[CATALYTIC] SUBUNIT (Homo sapiens) |
PF00648(Peptidase_C2) | 4 | ALA A 120LEU A 118ILE A 107SER A 275 | None | 1.02A | 1sbrA-1zcmA:undetectable1sbrB-1zcmA:undetectable | 1sbrA-1zcmA:22.921sbrB-1zcmA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2auj | DNA-DIRECTED RNAPOLYMERASE BETA'CHAIN (Thermusaquaticus) |
no annotation | 4 | PHE D 251ALA D 305LEU D 304ILE D 270 | None | 1.00A | 1sbrA-2aujD:undetectable1sbrB-2aujD:undetectable | 1sbrA-2aujD:20.971sbrB-2aujD:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bht | CYSTEINE SYNTHASE B (Escherichiacoli) |
PF00291(PALP) | 4 | PHE A 169ALA A 277SER A 171CYH A 252 | None | 1.03A | 1sbrA-2bhtA:undetectable1sbrB-2bhtA:undetectable | 1sbrA-2bhtA:20.581sbrB-2bhtA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cyb | TYROSYL-TRNASYNTHETASE (Archaeoglobusfulgidus) |
PF00579(tRNA-synt_1b) | 4 | ALA A 305LEU A 308ILE A 254CYH A 241 | None | 1.01A | 1sbrA-2cybA:undetectable1sbrB-2cybA:undetectable | 1sbrA-2cybA:20.611sbrB-2cybA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fus | FUMARASE C (Escherichiacoli) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 4 | PHE A 258ALA A 251LEU A 250ILE A 253 | None | 1.06A | 1sbrA-2fusA:undetectable1sbrB-2fusA:undetectable | 1sbrA-2fusA:18.591sbrB-2fusA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hj0 | PUTATIVE CITRATELYASE, ALFA SUBUNIT (Streptococcusmutans) |
PF04223(CitF) | 4 | PHE A 304ALA A 305LEU A 306SER A 275 | None | 0.86A | 1sbrA-2hj0A:undetectable1sbrB-2hj0A:undetectable | 1sbrA-2hj0A:17.941sbrB-2hj0A:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgp | TYROCIDINESYNTHETASE 3 (Brevibacillusbrevis) |
PF00550(PP-binding)PF00668(Condensation) | 4 | ALA A 15LEU A 17ILE A 72SER A 11 | None | 1.07A | 1sbrA-2jgpA:undetectable1sbrB-2jgpA:1.5 | 1sbrA-2jgpA:18.641sbrB-2jgpA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nqa | CALPAIN 8 (Homo sapiens) |
PF00648(Peptidase_C2) | 4 | ALA A 110LEU A 108ILE A 97SER A 265 | NoneNoneCSO A 98 ( 4.0A)None | 1.06A | 1sbrA-2nqaA:undetectable1sbrB-2nqaA:undetectable | 1sbrA-2nqaA:20.801sbrB-2nqaA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oas | 4-HYDROXYBUTYRATECOENZYME ATRANSFERASE (Shewanellaoneidensis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 4 | PHE A 264ALA A 265LEU A 266ILE A 211 | None | 1.05A | 1sbrA-2oasA:undetectable1sbrB-2oasA:undetectable | 1sbrA-2oasA:19.631sbrB-2oasA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p97 | HYPOTHETICAL PROTEIN (Trichormusvariabilis) |
PF14597(Lactamase_B_5) | 4 | ALA A 175LEU A 132ILE A 133SER A 183 | None | 0.98A | 1sbrA-2p97A:undetectable1sbrB-2p97A:undetectable | 1sbrA-2p97A:22.071sbrB-2p97A:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p9b | POSSIBLE PROLIDASE (Bifidobacteriumlongum) |
PF01979(Amidohydro_1) | 4 | PHE A 14ALA A 15LEU A 16ILE A 36 | None | 0.86A | 1sbrA-2p9bA:undetectable1sbrB-2p9bA:undetectable | 1sbrA-2p9bA:19.261sbrB-2p9bA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qya | UNCHARACTERIZEDCONSERVED PROTEIN (Methanopyruskandleri) |
PF04242(DUF424) | 4 | ALA A 18LEU A 17ILE A 72CYH A 80 | None | 0.87A | 1sbrA-2qyaA:undetectable1sbrB-2qyaA:undetectable | 1sbrA-2qyaA:20.001sbrB-2qyaA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r26 | CITRATE SYNTHASE (Thermoplasmaacidophilum) |
PF00285(Citrate_synt) | 4 | ALA A 180LEU A 183ILE A 182SER A 343 | None | 1.03A | 1sbrA-2r26A:undetectable1sbrB-2r26A:undetectable | 1sbrA-2r26A:17.971sbrB-2r26A:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rb9 | HYPE PROTEIN (Escherichiacoli) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | ALA A 117ILE A 77SER A 115CYH A 96 | None | 1.00A | 1sbrA-2rb9A:undetectable1sbrB-2rb9A:1.8 | 1sbrA-2rb9A:21.841sbrB-2rb9A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vpv | PROTEIN MIF2 (Saccharomycescerevisiae) |
PF11699(CENP-C_C) | 4 | PHE A 439ALA A 440LEU A 441SER A 469 | None | 1.06A | 1sbrA-2vpvA:undetectable1sbrB-2vpvA:undetectable | 1sbrA-2vpvA:17.501sbrB-2vpvA:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yvh | TRANSCRIPTIONALREGULATOR (Corynebacteriumglutamicum) |
PF00440(TetR_N) | 4 | PHE A 109ALA A 103LEU A 99SER A 105 | None | 0.99A | 1sbrA-2yvhA:undetectable1sbrB-2yvhA:undetectable | 1sbrA-2yvhA:23.871sbrB-2yvhA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yy6 | PHOSPHOGLYCOLATEPHOSPHATASE (Aquifexaeolicus) |
PF13419(HAD_2) | 4 | PHE A 124ALA A 101LEU A 100ILE A 4 | None | 0.99A | 1sbrA-2yy6A:undetectable1sbrB-2yy6A:undetectable | 1sbrA-2yy6A:21.931sbrB-2yy6A:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2m | PENICILLIN-BINDINGPROTEIN 2X (Streptococcuspneumoniae) |
PF00905(Transpeptidase) | 4 | ALA B 508LEU B 510ILE B 348SER B 504 | None | 1.06A | 1sbrA-2z2mB:undetectable1sbrB-2z2mB:undetectable | 1sbrA-2z2mB:21.711sbrB-2z2mB:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c8e | YGHU, GLUTATHIONES-TRANSFERASEHOMOLOGUE (Escherichiacoli) |
PF02798(GST_N)PF13410(GST_C_2) | 4 | ALA A 103LEU A 104ILE A 121SER A 49 | None | 0.92A | 1sbrA-3c8eA:undetectable1sbrB-3c8eA:undetectable | 1sbrA-3c8eA:21.921sbrB-3c8eA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dra | GERANYLGERANYLTRANSFERASE TYPE I BETASUBUNIT (Candidaalbicans) |
PF00432(Prenyltrans) | 4 | ALA B 33LEU B 32ILE B 35CYH B 16 | None | 1.01A | 1sbrA-3draB:undetectable1sbrB-3draB:undetectable | 1sbrA-3draB:16.931sbrB-3draB:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egl | DEGV FAMILY PROTEIN (Corynebacteriumglutamicum) |
PF02645(DegV) | 4 | ALA A 11LEU A 99ILE A 68SER A 9 | NonePLM A 275 ( 4.6A)NoneNone | 1.07A | 1sbrA-3eglA:undetectable1sbrB-3eglA:undetectable | 1sbrA-3eglA:22.461sbrB-3eglA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fys | PROTEIN DEGV (Bacillussubtilis) |
PF02645(DegV) | 4 | ALA A 122LEU A 121ILE A 232SER A 119 | NoneNonePLM A 501 (-4.0A)PLM A 501 ( 4.7A) | 0.94A | 1sbrA-3fysA:undetectable1sbrB-3fysA:undetectable | 1sbrA-3fysA:20.391sbrB-3fysA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g79 | NDP-N-ACETYL-D-GALACTOSAMINURONIC ACIDDEHYDROGENASE (Methanosarcinamazei) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 4 | PHE A 174ALA A 175LEU A 176ILE A 202 | None | 0.94A | 1sbrA-3g79A:undetectable1sbrB-3g79A:undetectable | 1sbrA-3g79A:17.341sbrB-3g79A:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7k | 3-METHYLITACONATEISOMERASE (Eubacteriumbarkeri) |
PF04303(PrpF) | 4 | PHE A 42ALA A 54LEU A 53ILE A 11 | None | 1.07A | 1sbrA-3g7kA:undetectable1sbrB-3g7kA:undetectable | 1sbrA-3g7kA:21.431sbrB-3g7kA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3huu | TRANSCRIPTIONREGULATOR LIKEPROTEIN (Staphylococcushaemolyticus) |
PF13377(Peripla_BP_3) | 4 | ALA A 130LEU A 133ILE A 205CYH A 177 | None | 1.07A | 1sbrA-3huuA:undetectable1sbrB-3huuA:undetectable | 1sbrA-3huuA:19.681sbrB-3huuA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ila | RYANODINE RECEPTOR 1 (Oryctolaguscuniculus) |
PF08709(Ins145_P3_rec) | 4 | PHE A 133ALA A 132LEU A 131SER A 124 | None | 0.94A | 1sbrA-3ilaA:undetectable1sbrB-3ilaA:undetectable | 1sbrA-3ilaA:19.641sbrB-3ilaA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kty | PROBABLEMETHYLTRANSFERASE (Bordetellapertussis) |
PF00588(SpoU_methylase) | 4 | ALA A 161LEU A 160ILE A 143CYH A 97 | None | 1.02A | 1sbrA-3ktyA:undetectable1sbrB-3ktyA:undetectable | 1sbrA-3ktyA:24.371sbrB-3ktyA:24.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lu2 | LMO2462 PROTEIN (Listeriamonocytogenes) |
PF01244(Peptidase_M19) | 4 | ALA A 195LEU A 205ILE A 220CYH A 248 | None | 0.89A | 1sbrA-3lu2A:undetectable1sbrB-3lu2A:undetectable | 1sbrA-3lu2A:20.061sbrB-3lu2A:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o6x | GLUTAMINE SYNTHETASE (Bacteroidesfragilis) |
PF00120(Gln-synt_C)PF12437(GSIII_N) | 4 | ALA A 548LEU A 552ILE A 408CYH A 556 | None | 0.99A | 1sbrA-3o6xA:2.91sbrB-3o6xA:0.9 | 1sbrA-3o6xA:13.361sbrB-3o6xA:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oib | ACYL-COADEHYDROGENASE (Mycolicibacteriumsmegmatis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | ALA A 108LEU A 110ILE A 58SER A 181 | None | 1.07A | 1sbrA-3oibA:undetectable1sbrB-3oibA:undetectable | 1sbrA-3oibA:20.201sbrB-3oibA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q7h | ATP-DEPENDENT CLPPROTEASE PROTEOLYTICSUBUNIT (Coxiellaburnetii) |
PF00574(CLP_protease) | 4 | ALA A 102LEU A 104ILE A 65CYH A 115 | None | 0.98A | 1sbrA-3q7hA:undetectable1sbrB-3q7hA:undetectable | 1sbrA-3q7hA:22.071sbrB-3q7hA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r3j | GLUTAMATEDEHYDROGENASE (Plasmodiumfalciparum) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | PHE A 279ALA A 280ILE A 427CYH A 402 | None | 0.93A | 1sbrA-3r3jA:undetectable1sbrB-3r3jA:undetectable | 1sbrA-3r3jA:17.031sbrB-3r3jA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tg9 | PENICILLIN-BINDINGPROTEIN (Bacillushalodurans) |
PF00144(Beta-lactamase) | 4 | ALA A 18LEU A 19SER A 31CYH A 295 | None | 1.05A | 1sbrA-3tg9A:undetectable1sbrB-3tg9A:undetectable | 1sbrA-3tg9A:21.801sbrB-3tg9A:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqy | SINGLE-STRANDEDDNA-BINDING PROTEIN (Coxiellaburnetii) |
PF00436(SSB) | 4 | PHE A 62ALA A 67LEU A 66ILE A 69 | None | 1.07A | 1sbrA-3tqyA:undetectable1sbrB-3tqyA:undetectable | 1sbrA-3tqyA:19.231sbrB-3tqyA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3unv | ADMH (Pantoeaagglomerans) |
PF00221(Lyase_aromatic) | 4 | ALA A 217LEU A 216ILE A 219CYH A 181 | None | 1.07A | 1sbrA-3unvA:undetectable1sbrB-3unvA:undetectable | 1sbrA-3unvA:16.761sbrB-3unvA:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4arp | PESTICIN (Yersinia pestis) |
PF16754(Pesticin) | 4 | ALA A 256LEU A 258ILE A 225SER A 252 | None | 0.99A | 1sbrA-4arpA:undetectable1sbrB-4arpA:undetectable | 1sbrA-4arpA:20.061sbrB-4arpA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c7v | TRANSKETOLASE (Lactobacillussalivarius) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | ALA A 173LEU A 176SER A 171CYH A 416 | None | 0.97A | 1sbrA-4c7vA:undetectable1sbrB-4c7vA:undetectable | 1sbrA-4c7vA:15.841sbrB-4c7vA:15.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c9b | PRE-MRNA-SPLICINGFACTOR CWC22 HOMOLOG (Homo sapiens) |
PF02854(MIF4G) | 4 | PHE B 296ALA B 293LEU B 297ILE B 315 | None | 0.93A | 1sbrA-4c9bB:undetectable1sbrB-4c9bB:undetectable | 1sbrA-4c9bB:21.481sbrB-4c9bB:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ce4 | MRPL20 (Sus scrofa) |
PF00453(Ribosomal_L20) | 4 | PHE U 113ALA U 117LEU U 116SER U 76 | None | 1.04A | 1sbrA-4ce4U:undetectable1sbrB-4ce4U:undetectable | 1sbrA-4ce4U:17.071sbrB-4ce4U:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dza | LYSINE RACEMASE (Proteusmirabilis) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 4 | ALA A 312LEU A 311ILE A 351SER A 287 | None | 0.90A | 1sbrA-4dzaA:undetectable1sbrB-4dzaA:undetectable | 1sbrA-4dzaA:20.841sbrB-4dzaA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ep6 | CYTOCHROME P450-LIKEPROTEIN XPLA (Rhodococcusrhodochrous) |
PF00067(p450) | 4 | ALA A 349LEU A 352ILE A 382SER A 345 | None | 1.04A | 1sbrA-4ep6A:undetectable1sbrB-4ep6A:undetectable | 1sbrA-4ep6A:19.741sbrB-4ep6A:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f53 | SUSD HOMOLOG (Bacteroidesovatus) |
PF12741(SusD-like) | 4 | PHE A 216ALA A 217LEU A 220ILE A 141 | None | 0.98A | 1sbrA-4f53A:undetectable1sbrB-4f53A:undetectable | 1sbrA-4f53A:17.071sbrB-4f53A:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g9k | ROTENONE-INSENSITIVENADH-UBIQUINONEOXIDOREDUCTASE (Saccharomycescerevisiae) |
PF07992(Pyr_redox_2) | 4 | PHE A 68ALA A 65LEU A 69ILE A 81 | PHE A 68 ( 1.3A)ALA A 65 ( 0.0A)LEU A 69 ( 0.6A)ILE A 81 ( 0.4A) | 1.08A | 1sbrA-4g9kA:undetectable1sbrB-4g9kA:undetectable | 1sbrA-4g9kA:17.931sbrB-4g9kA:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gwb | PEPTIDE METHIONINESULFOXIDE REDUCTASEMSRA 3 (Sinorhizobiummeliloti) |
PF01625(PMSR) | 4 | ALA A 8LEU A 7ILE A 94SER A 92 | None | 1.06A | 1sbrA-4gwbA:undetectable1sbrB-4gwbA:undetectable | 1sbrA-4gwbA:21.961sbrB-4gwbA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jn6 | 4-HYDROXY-2-OXOVALERATE ALDOLASE (Mycobacteriumtuberculosis) |
PF00682(HMGL-like)PF07836(DmpG_comm) | 4 | PHE A 124ALA A 159ILE A 155SER A 120 | None | 1.08A | 1sbrA-4jn6A:undetectable1sbrB-4jn6A:undetectable | 1sbrA-4jn6A:21.371sbrB-4jn6A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrm | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Vibrio cholerae) |
no annotation | 4 | ALA D 163LEU D 344ILE D 109SER D 161 | None | 1.08A | 1sbrA-4jrmD:undetectable1sbrB-4jrmD:undetectable | 1sbrA-4jrmD:19.621sbrB-4jrmD:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k0d | PERIPLASMIC SENSORHYBRID HISTIDINEKINASE (Anaeromyxobacterdehalogenans) |
no annotation | 4 | PHE A 98ALA A 99LEU A 101SER A 111 | None | 1.04A | 1sbrA-4k0dA:undetectable1sbrB-4k0dA:undetectable | 1sbrA-4k0dA:23.581sbrB-4k0dA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l4i | RYANODINE RECEPTOR 2 (Mus musculus) |
PF01365(RYDR_ITPR)PF02815(MIR)PF08709(Ins145_P3_rec) | 4 | PHE A 145ALA A 144LEU A 143SER A 136 | None | 0.98A | 1sbrA-4l4iA:undetectable1sbrB-4l4iA:undetectable | 1sbrA-4l4iA:16.271sbrB-4l4iA:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgl | GLYCINEDEHYDROGENASE[DECARBOXYLATING] (Synechocystissp. PCC 6803) |
PF02347(GDC-P) | 4 | ALA A 302LEU A 359ILE A 293SER A 287 | None | 1.00A | 1sbrA-4lglA:undetectable1sbrB-4lglA:undetectable | 1sbrA-4lglA:12.501sbrB-4lglA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lz6 | BH2163 PROTEIN (Bacillushalodurans) |
PF01554(MatE) | 4 | PHE A 151LEU A 107ILE A 110SER A 147 | None | 0.91A | 1sbrA-4lz6A:undetectable1sbrB-4lz6A:undetectable | 1sbrA-4lz6A:17.711sbrB-4lz6A:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4myd | 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATESYNTHASE (Escherichiacoli) |
PF12697(Abhydrolase_6) | 4 | LEU A 43ILE A 77SER A 41CYH A 104 | None | 0.95A | 1sbrA-4mydA:undetectable1sbrB-4mydA:undetectable | 1sbrA-4mydA:19.711sbrB-4mydA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mzw | GLUTATHIONES-TRANSFERASE (Streptococcussanguinis) |
PF02798(GST_N)PF13410(GST_C_2) | 4 | ALA A 100LEU A 101ILE A 118SER A 46 | None | 0.95A | 1sbrA-4mzwA:undetectable1sbrB-4mzwA:undetectable | 1sbrA-4mzwA:21.581sbrB-4mzwA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n0i | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF01425(Amidase) | 4 | PHE A 145ALA A 146LEU A 147ILE A 51 | None | 0.86A | 1sbrA-4n0iA:undetectable1sbrB-4n0iA:undetectable | 1sbrA-4n0iA:18.751sbrB-4n0iA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pua | GLUTATHIONES-TRANSFERASE (Streptococcuspneumoniae) |
PF02798(GST_N)PF13410(GST_C_2) | 4 | ALA A 101LEU A 102ILE A 119SER A 47 | None | 0.89A | 1sbrA-4puaA:undetectable1sbrB-4puaA:undetectable | 1sbrA-4puaA:22.761sbrB-4puaA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rtb | HYDG PROTEIN (Carboxydothermushydrogenoformans) |
PF04055(Radical_SAM)PF06968(BATS) | 4 | PHE A 79ALA A 80LEU A 130SER A 325 | NoneNoneNone CL A 507 (-4.7A) | 1.05A | 1sbrA-4rtbA:undetectable1sbrB-4rtbA:undetectable | 1sbrA-4rtbA:17.111sbrB-4rtbA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ryb | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Neisseriameningitidis) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | ALA A 136LEU A 137ILE A 74SER A 169 | None | 1.05A | 1sbrA-4rybA:undetectable1sbrB-4rybA:undetectable | 1sbrA-4rybA:24.531sbrB-4rybA:24.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s13 | FERULIC ACIDDECARBOXYLASE 1 (Saccharomycescerevisiae) |
PF01977(UbiD) | 4 | PHE A 212ALA A 213LEU A 214CYH A 124 | None | 0.88A | 1sbrA-4s13A:undetectable1sbrB-4s13A:undetectable | 1sbrA-4s13A:17.361sbrB-4s13A:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tpg | PROTON:OLIGOPEPTIDESYMPORTER POT FAMILY (Shewanellaoneidensis) |
PF00854(PTR2) | 4 | ALA A 109LEU A 110ILE A 113CYH A 186 | None | 0.94A | 1sbrA-4tpgA:undetectable1sbrB-4tpgA:undetectable | 1sbrA-4tpgA:16.571sbrB-4tpgA:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tq5 | PRENYLTRANSFERASE (Archaeoglobusfulgidus) |
PF01040(UbiA) | 4 | ALA A 50LEU A 52ILE A 121SER A 46 | None | 0.96A | 1sbrA-4tq5A:undetectable1sbrB-4tq5A:undetectable | 1sbrA-4tq5A:22.741sbrB-4tq5A:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uar | PROTEIN CBBY (Rhodobactersphaeroides) |
PF13419(HAD_2) | 4 | PHE A 138ALA A 112LEU A 111ILE A 5 | None | 1.06A | 1sbrA-4uarA:undetectable1sbrB-4uarA:undetectable | 1sbrA-4uarA:20.431sbrB-4uarA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uml | GANGLIOSIDE-INDUCEDDIFFERENTIATION-ASSOCIATED PROTEIN 2 (Homo sapiens) |
PF01661(Macro) | 4 | ALA A 156LEU A 155ILE A 126CYH A 68 | None | 1.06A | 1sbrA-4umlA:undetectable1sbrB-4umlA:undetectable | 1sbrA-4umlA:20.171sbrB-4umlA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uwa | RYANODINE RECEPTOR 1 (Oryctolaguscuniculus) |
PF00622(SPRY)PF01365(RYDR_ITPR)PF02026(RyR)PF02815(MIR)PF08709(Ins145_P3_rec) | 4 | PHE A 133ALA A 132LEU A 131SER A 124 | None | 1.02A | 1sbrA-4uwaA:undetectable1sbrB-4uwaA:undetectable | 1sbrA-4uwaA:4.381sbrB-4uwaA:4.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8x | CRISPR SYSTEM CMRSUBUNIT CMR1-1 (Pyrococcusfuriosus) |
PF03787(RAMPs) | 4 | PHE A 6LEU A 125ILE A 133SER A 167 | None | 1.00A | 1sbrA-4w8xA:2.31sbrB-4w8xA:undetectable | 1sbrA-4w8xA:18.501sbrB-4w8xA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wd9 | NISIN BIOSYNTHESISPROTEIN NISB (Lactococcuslactis) |
PF04738(Lant_dehydr_N)PF14028(Lant_dehydr_C) | 4 | PHE A1011ILE A 179SER A 210CYH A 184 | None | 0.99A | 1sbrA-4wd9A:undetectable1sbrB-4wd9A:undetectable | 1sbrA-4wd9A:10.291sbrB-4wd9A:10.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ztc | AMINOTRANSFERASEHOMOLOG (Campylobacterjejuni) |
PF01041(DegT_DnrJ_EryC1) | 4 | ALA A 77LEU A 76SER A 79CYH A 90 | None | 0.98A | 1sbrA-4ztcA:undetectable1sbrB-4ztcA:undetectable | 1sbrA-4ztcA:20.971sbrB-4ztcA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b2o | CRISPR-ASSOCIATEDENDONUCLEASE CAS9 (Francisellatularensis) |
no annotation | 4 | PHE A 99LEU A 98ILE A 319SER A 361 | None | 0.99A | 1sbrA-5b2oA:undetectable1sbrB-5b2oA:undetectable | 1sbrA-5b2oA:8.081sbrB-5b2oA:8.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME SUBUNITALPHA TYPE (Plasmodiumfalciparum) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 4 | PHE D 40ALA D 41ILE D 35SER D 37 | None | 0.94A | 1sbrA-5fmgD:undetectable1sbrB-5fmgD:undetectable | 1sbrA-5fmgD:21.661sbrB-5fmgD:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gxf | ACRYLYL-COAREDUCTASE ACUI (Ruegeriapomeroyi) |
PF00107(ADH_zinc_N) | 4 | ALA A 134LEU A 136ILE A 270CYH A 220 | None | 1.04A | 1sbrA-5gxfA:undetectable1sbrB-5gxfA:undetectable | 1sbrA-5gxfA:18.981sbrB-5gxfA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hm5 | TOPOISOMERASE V (Methanopyruskandleri) |
PF13412(HTH_24)PF14520(HHH_5) | 4 | PHE A 576ALA A 581LEU A 584ILE A 594 | None | 1.04A | 1sbrA-5hm5A:undetectable1sbrB-5hm5A:undetectable | 1sbrA-5hm5A:12.881sbrB-5hm5A:12.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hqw | PUTATIVE POLYKETIDESYNTHASE (Brevibacillusbrevis) |
PF14765(PS-DH) | 4 | ALA A2425LEU A2423ILE A2478CYH A2481 | None | 0.99A | 1sbrA-5hqwA:undetectable1sbrB-5hqwA:undetectable | 1sbrA-5hqwA:20.471sbrB-5hqwA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6e | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF08326(ACC_central) | 4 | ALA A1361LEU A1364ILE A1342SER A1359 | None | 1.08A | 1sbrA-5i6eA:undetectable1sbrB-5i6eA:undetectable | 1sbrA-5i6eA:14.141sbrB-5i6eA:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ir6 | BD-TYPE QUINOLOXIDASE SUBUNIT I (Geobacillusstearothermophilus) |
PF01654(Cyt_bd_oxida_I) | 4 | PHE A 197ALA A 366LEU A 365ILE A 328 | None | 1.05A | 1sbrA-5ir6A:undetectable1sbrB-5ir6A:undetectable | 1sbrA-5ir6A:19.651sbrB-5ir6A:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iva | LPS-ASSEMBLY PROTEINLPTD (Pseudomonasaeruginosa) |
PF04453(OstA_C) | 4 | PHE A 572ALA A 557LEU A 556ILE A 546 | NoneC8E A 701 ( 4.1A)NoneNone | 1.06A | 1sbrA-5ivaA:undetectable1sbrB-5ivaA:undetectable | 1sbrA-5ivaA:14.261sbrB-5ivaA:14.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j32 | 3-ISOPROPYLMALATEDEHYDROGENASE 2,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00180(Iso_dh) | 4 | ALA A 337LEU A 340ILE A 339CYH A 386 | None | 0.95A | 1sbrA-5j32A:undetectable1sbrB-5j32A:undetectable | 1sbrA-5j32A:19.851sbrB-5j32A:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jay | 8-AMINO-7-OXONONANOATE SYNTHASE (Paraburkholderiaxenovorans) |
PF00155(Aminotran_1_2) | 4 | ALA A 115LEU A 117ILE A 269SER A 110 | None | 1.00A | 1sbrA-5jayA:undetectable1sbrB-5jayA:undetectable | 1sbrA-5jayA:19.801sbrB-5jayA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k6o | B-GLUCOSIDASE (metagenome) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | PHE A 602ALA A 555LEU A 554ILE A 563 | None | 1.02A | 1sbrA-5k6oA:undetectable1sbrB-5k6oA:undetectable | 1sbrA-5k6oA:12.131sbrB-5k6oA:12.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l20 | CLOSTRIPAIN-RELATEDPROTEIN (Bacteroidesthetaiotaomicron) |
PF03415(Peptidase_C11)no annotation | 4 | ALA B 380LEU B 379ILE A 146SER B 372 | None | 1.08A | 1sbrA-5l20B:undetectable1sbrB-5l20B:undetectable | 1sbrA-5l20B:24.781sbrB-5l20B:24.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mg5 | HYDROXYMETHYLGLUTARYL-COA SYNTHASE (Pseudomonasprotegens) |
no annotation | 4 | ALA A 77LEU A 78ILE A 75SER A 136 | None | 1.08A | 1sbrA-5mg5A:undetectable1sbrB-5mg5A:undetectable | 1sbrA-5mg5A:20.111sbrB-5mg5A:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nyk | THIOREDOXIN-LIKEPROTEIN 2.1 (Populus tremulax Populustremuloides) |
no annotation | 4 | ALA A 56LEU A 55SER A 7CYH A 67 | None | 0.87A | 1sbrA-5nykA:undetectable1sbrB-5nykA:undetectable | 1sbrA-5nykA:18.021sbrB-5nykA:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o6b | ATP-DEPENDENT DNAHELICASE PIF1 (Saccharomycescerevisiae) |
no annotation | 4 | ALA A 248LEU A 247ILE A 244CYH A 376 | None | 1.06A | 1sbrA-5o6bA:undetectable1sbrB-5o6bA:undetectable | 1sbrA-5o6bA:21.941sbrB-5o6bA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5okz | EXOSOME COMPLEXCOMPONENT MTR3 (Saccharomycescerevisiae) |
PF01138(RNase_PH) | 4 | ALA F 60LEU F 61ILE F 74SER F 175 | None | 1.03A | 1sbrA-5okzF:undetectable1sbrB-5okzF:undetectable | 1sbrA-5okzF:23.021sbrB-5okzF:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t1q | N-ACETYLMURAMOYL-L-ALANINE AMIDASEDOMAIN-CONTAININGPROTEINSAOUHSC_02979 (Staphylococcusaureus) |
PF01832(Glucosaminidase)PF05257(CHAP) | 4 | ALA A 349LEU A 351ILE A 462SER A 355 | None | 0.99A | 1sbrA-5t1qA:undetectable1sbrB-5t1qA:undetectable | 1sbrA-5t1qA:20.561sbrB-5t1qA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v9x | ATP-DEPENDENT DNAHELICASE (Mycolicibacteriumsmegmatis) |
no annotation | 4 | ALA A 847LEU A 849ILE A 679SER A 843 | None | 1.02A | 1sbrA-5v9xA:undetectable1sbrB-5v9xA:undetectable | 1sbrA-5v9xA:15.501sbrB-5v9xA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vf3 | CAPSID VERTEXPROTEIN GP24 (Escherichiavirus T4) |
PF07068(Gp23) | 4 | PHE a 197ALA a 194LEU a 198ILE a 179 | None | 1.03A | 1sbrA-5vf3a:undetectable1sbrB-5vf3a:undetectable | 1sbrA-5vf3a:18.071sbrB-5vf3a:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vg9 | PROTEIN-S-ISOPRENYLCYSTEINEO-METHYLTRANSFERASE (Triboliumcastaneum) |
no annotation | 4 | PHE A 13ALA A 69LEU A 71SER A 17 | None | 1.05A | 1sbrA-5vg9A:undetectable1sbrB-5vg9A:undetectable | 1sbrA-5vg9A:17.021sbrB-5vg9A:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y9v | RYANODINE RECEPTOR 1 (Plutellaxylostella) |
no annotation | 4 | PHE A 129ALA A 128LEU A 127SER A 121 | None | 0.79A | 1sbrA-5y9vA:undetectable1sbrB-5y9vA:undetectable | 1sbrA-5y9vA:17.101sbrB-5y9vA:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bdt | CALPAIN-3 (Homo sapiens) |
no annotation | 4 | ALA A 134LEU A 132ILE A 121SER A 337 | None | 1.05A | 1sbrA-6bdtA:undetectable1sbrB-6bdtA:undetectable | 1sbrA-6bdtA:15.001sbrB-6bdtA:15.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c6l | V-TYPE PROTON ATPASESUBUNIT A, VACUOLARISOFORM (Saccharomycescerevisiae) |
no annotation | 4 | ALA A 641LEU A 642ILE A 645CYH A 726 | None | 0.95A | 1sbrA-6c6lA:undetectable1sbrB-6c6lA:undetectable | 1sbrA-6c6lA:17.001sbrB-6c6lA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6emk | SERINE/THREONINE-PROTEIN KINASE TOR2 (Saccharomycescerevisiae) |
no annotation | 4 | ALA A1841LEU A1842ILE A2356SER A1837 | None | 0.94A | 1sbrA-6emkA:undetectable1sbrB-6emkA:undetectable | 1sbrA-6emkA:21.021sbrB-6emkA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fos | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2 (Cyanidioschyzonmerolae) |
no annotation | 4 | ALA B 232LEU B 253ILE B 252SER B 234 | None | 0.90A | 1sbrA-6fosB:undetectable1sbrB-6fosB:undetectable | 1sbrA-6fosB:17.741sbrB-6fosB:17.74 |