SIMILAR PATTERNS OF AMINO ACIDS FOR 1SA1_D_PODD701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awb MYO-INOSITOL
MONOPHOSPHATASE

(Homo sapiens) 		PF00459
(Inositol_P) 		5 VAL A 193
LEU A 235
ALA A 252
ASN A 199
VAL A 148
 None
 1.07A 1sa1C-1awbA:
undetectable
1sa1D-1awbA:
undetectable		 1sa1C-1awbA:
21.51
1sa1D-1awbA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dof ADENYLOSUCCINATE
LYASE

(Pyrobaculum
aerophilum) 		PF00206
(Lyase_1) 		5 VAL A 290
LEU A 170
ALA A 229
LEU A 226
ALA A 316
 None
 1.04A 1sa1C-1dofA:
undetectable
1sa1D-1dofA:
undetectable		 1sa1C-1dofA:
20.00
1sa1D-1dofA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		5 VAL A  27
ALA A  35
LEU A 103
ALA A  56
ALA A  60
 None
 1.17A 1sa1C-1g38A:
2.1
1sa1D-1g38A:
undetectable		 1sa1C-1g38A:
20.39
1sa1D-1g38A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		5 VAL A 197
LEU A 213
ALA A 190
LEU A 201
VAL A 221
 None
 1.16A 1sa1C-1gm5A:
1.2
1sa1D-1gm5A:
undetectable		 1sa1C-1gm5A:
20.81
1sa1D-1gm5A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ode CHORISMATE MUTASE

(Thermus
thermophilus) 		PF07736
(CM_1) 		5 LEU A  28
LEU A  31
ASN A  34
ALA A  92
VAL A  90
 None
 1.11A 1sa1C-1odeA:
undetectable
1sa1D-1odeA:
undetectable		 1sa1C-1odeA:
14.74
1sa1D-1odeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ode CHORISMATE MUTASE

(Thermus
thermophilus) 		PF07736
(CM_1) 		5 VAL A 103
LEU A  28
LEU A  31
ASN A  34
ALA A  92
 None
 1.00A 1sa1C-1odeA:
undetectable
1sa1D-1odeA:
undetectable		 1sa1C-1odeA:
14.74
1sa1D-1odeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU D 131
ALA D 134
ALA D 107
VAL D 110
ALA D 101
 None
 1.16A 1sa1C-1oy3D:
0.6
1sa1D-1oy3D:
undetectable		 1sa1C-1oy3D:
22.67
1sa1D-1oy3D:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qp8 FORMATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A  91
ALA A  90
LEU A  94
ALA A 178
VAL A 129
 None
 1.18A 1sa1C-1qp8A:
0.9
1sa1D-1qp8A:
1.3		 1sa1C-1qp8A:
19.09
1sa1D-1qp8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ral 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 VAL A 234
LEU A 257
ALA A 256
LEU A 219
ALA A 245
 None
 1.07A 1sa1C-1ralA:
1.9
1sa1D-1ralA:
2.0		 1sa1C-1ralA:
22.77
1sa1D-1ralA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B

(Pyrococcus
horikoshii) 		PF01008
(IF-2B) 		5 LEU A  33
ALA A  85
LEU A  89
MET A  92
ALA A  25
 None
 1.09A 1sa1C-1vb5A:
3.5
1sa1D-1vb5A:
3.8		 1sa1C-1vb5A:
19.60
1sa1D-1vb5A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 LEU A 198
ALA A 172
LEU A 294
ALA A 286
ALA A 175
 None
 1.06A 1sa1C-1ve5A:
undetectable
1sa1D-1ve5A:
undetectable		 1sa1C-1ve5A:
20.30
1sa1D-1ve5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Sulfurisphaera
tokodaii) 		PF00908
(dTDP_sugar_isom) 		5 VAL A  75
LEU A  14
ALA A 100
VAL A  98
ALA A  84
 None
 0.97A 1sa1C-1wltA:
undetectable
1sa1D-1wltA:
undetectable		 1sa1C-1wltA:
16.89
1sa1D-1wltA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A 337
LEU A  43
ALA A  92
VAL A  46
ALA A  96
 VAL  A 337 ( 0.6A)
LEU  A  43 ( 0.6A)
ALA  A  92 ( 0.0A)
VAL  A  46 ( 0.6A)
ALA  A  96 ( 0.0A)
 1.09A 1sa1C-1wqaA:
undetectable
1sa1D-1wqaA:
undetectable		 1sa1C-1wqaA:
23.84
1sa1D-1wqaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HSPBP1 PROTEIN

(Homo sapiens) 		PF08609
(Fes1) 		5 VAL A 248
LEU A 195
ALA A 208
ALA A 238
VAL A 234
 None
 1.08A 1sa1C-1xqsA:
undetectable
1sa1D-1xqsA:
undetectable		 1sa1C-1xqsA:
20.54
1sa1D-1xqsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		5 VAL A 606
ALA A 437
ALA A 579
VAL A 573
ALA A 571
 None
 1.19A 1sa1C-2c3oA:
3.4
1sa1D-2c3oA:
3.3		 1sa1C-2c3oA:
16.90
1sa1D-2c3oA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chr CHLOROMUCONATE
CYCLOISOMERASE

(Cupriavidus
necator) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  75
ALA A  72
LEU A  71
VAL A  34
ALA A   8
 None
 1.14A 1sa1C-2chrA:
undetectable
1sa1D-2chrA:
3.3		 1sa1C-2chrA:
23.01
1sa1D-2chrA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		5 VAL A 345
LEU A 423
ALA A 408
ALA A 360
VAL A 397
 None
 1.14A 1sa1C-2csuA:
undetectable
1sa1D-2csuA:
2.8		 1sa1C-2csuA:
23.09
1sa1D-2csuA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum) 		PF02233
(PNTB) 		5 VAL C  78
ALA C 157
MET C  43
VAL C  52
ALA C  83
 None
 0.95A 1sa1C-2fsvC:
3.5
1sa1D-2fsvC:
3.2		 1sa1C-2fsvC:
17.79
1sa1D-2fsvC:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irw CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Homo sapiens) 		PF00106
(adh_short) 		5 CYH A  78
LEU A  79
ALA A  83
MET A 110
ALA A  51
 None
 0.99A 1sa1C-2irwA:
7.0
1sa1D-2irwA:
7.1		 1sa1C-2irwA:
19.18
1sa1D-2irwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 VAL A 427
LEU A 331
ALA A 280
ASN A 175
MET A 176
 None
HEM  A 501 (-4.2A)
None
None
None
 1.11A 1sa1C-2j2mA:
undetectable
1sa1D-2j2mA:
undetectable		 1sa1C-2j2mA:
20.31
1sa1D-2j2mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2job ANTILIPOPOLYSACCHARI
DE FACTOR

(Penaeus monodon) 		PF11630
(DUF3254) 		5 ALA A  85
MET A  53
ALA A  78
VAL A  14
ALA A  11
 None
 1.20A 1sa1C-2jobA:
undetectable
1sa1D-2jobA:
undetectable		 1sa1C-2jobA:
13.40
1sa1D-2jobA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6f FOCAL ADHESION
KINASE 1, LINKER1,
PAXILLIN, LINKER2,
PAXILLIN

(Gallus gallus;
unidentified) 		PF03535
(Paxillin)
PF03623
(Focal_AT) 		5 LEU A  51
LEU A  54
ASN A  17
VAL A  25
ALA A  24
 None
 1.14A 1sa1C-2l6fA:
undetectable
1sa1D-2l6fA:
undetectable		 1sa1C-2l6fA:
17.16
1sa1D-2l6fA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7n TALIN-1

(Mus musculus) 		no annotation 5 CYH A1087
LEU A1091
ALA A1134
ALA A1140
LYS A1077
 None
 1.09A 1sa1C-2l7nA:
undetectable
1sa1D-2l7nA:
undetectable		 1sa1C-2l7nA:
18.75
1sa1D-2l7nA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER PERMEASE
PROTEIN HI1471

(Haemophilus
influenzae) 		PF01032
(FecCD) 		5 VAL A 300
ALA A  21
ASN A 299
ALA A  69
ALA A 291
 None
 1.20A 1sa1C-2nq2A:
undetectable
1sa1D-2nq2A:
undetectable		 1sa1C-2nq2A:
20.53
1sa1D-2nq2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg1 DYNEIN LIGHT CHAIN
TCTEX-TYPE

(Drosophila
melanogaster) 		PF03645
(Tctex-1) 		5 VAL E  37
CYH E  48
ALA E  22
ALA E  65
VAL E  63
 None
 1.11A 1sa1C-2pg1E:
undetectable
1sa1D-2pg1E:
undetectable		 1sa1C-2pg1E:
12.50
1sa1D-2pg1E:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE

(Corynebacterium
glutamicum) 		PF00478
(IMPDH) 		5 LEU A 162
ALA A 140
ASN A  53
VAL A 143
ALA A  79
 None
 1.11A 1sa1C-2qr6A:
undetectable
1sa1D-2qr6A:
undetectable		 1sa1C-2qr6A:
22.06
1sa1D-2qr6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qya UNCHARACTERIZED
CONSERVED PROTEIN

(Methanopyrus
kandleri) 		PF04242
(DUF424) 		5 VAL A  70
ALA A  74
LEU A  19
VAL A  84
ALA A  89
 None
 1.07A 1sa1C-2qyaA:
undetectable
1sa1D-2qyaA:
undetectable		 1sa1C-2qyaA:
12.64
1sa1D-2qyaA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfa HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE,
HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens;
Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		5 ALA A  58
MET A 103
ALA A  72
VAL A 141
ALA A 169
 None
 1.20A 1sa1C-2vfaA:
undetectable
1sa1D-2vfaA:
undetectable		 1sa1C-2vfaA:
19.08
1sa1D-2vfaA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE

(Rhodospirillum
rubrum) 		PF03747
(ADP_ribosyl_GH) 		5 VAL A 150
LEU A 293
ALA A 291
LEU A 140
VAL A 284
 None
 1.01A 1sa1C-2wocA:
undetectable
1sa1D-2wocA:
undetectable		 1sa1C-2wocA:
22.81
1sa1D-2wocA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze3 DFA0005

(Deinococcus
ficus) 		PF13714
(PEP_mutase) 		5 VAL A 146
ALA A 150
LEU A 111
ALA A 135
ALA A 180
 None
 1.19A 1sa1C-2ze3A:
undetectable
1sa1D-2ze3A:
2.1		 1sa1C-2ze3A:
21.49
1sa1D-2ze3A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)

(Rattus
norvegicus) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		5 VAL A  44
LEU A 117
ALA A 125
LEU A  40
ALA A 109
 None
 1.18A 1sa1C-3bifA:
undetectable
1sa1D-3bifA:
undetectable		 1sa1C-3bifA:
22.33
1sa1D-3bifA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 LEU A 128
ALA A 165
LEU A 161
ALA A 132
ALA A 169
 None
 1.05A 1sa1C-3c4qA:
5.7
1sa1D-3c4qA:
6.1		 1sa1C-3c4qA:
23.09
1sa1D-3c4qA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 VAL A1143
LEU A1166
ALA A1167
ALA A1174
ALA A1214
 None
 1.15A 1sa1C-3cmtA:
undetectable
1sa1D-3cmtA:
undetectable		 1sa1C-3cmtA:
14.81
1sa1D-3cmtA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 VAL A2143
LEU A2166
ALA A2167
ALA A2174
ALA A2214
 None
 1.16A 1sa1C-3cmtA:
undetectable
1sa1D-3cmtA:
undetectable		 1sa1C-3cmtA:
14.81
1sa1D-3cmtA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 VAL A3143
LEU A3166
ALA A3167
ALA A3174
ALA A3214
 None
 1.15A 1sa1C-3cmtA:
undetectable
1sa1D-3cmtA:
undetectable		 1sa1C-3cmtA:
14.81
1sa1D-3cmtA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 VAL A 143
LEU A 166
ALA A 167
ALA A 174
ALA A 214
 None
 1.09A 1sa1C-3cmuA:
undetectable
1sa1D-3cmuA:
undetectable		 1sa1C-3cmuA:
12.85
1sa1D-3cmuA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 VAL A1143
LEU A1166
ALA A1167
ALA A1174
ALA A1214
 None
 1.09A 1sa1C-3cmuA:
undetectable
1sa1D-3cmuA:
undetectable		 1sa1C-3cmuA:
12.85
1sa1D-3cmuA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 VAL A2143
LEU A2166
ALA A2167
ALA A2174
ALA A2214
 None
 1.10A 1sa1C-3cmuA:
undetectable
1sa1D-3cmuA:
undetectable		 1sa1C-3cmuA:
12.85
1sa1D-3cmuA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 VAL A3143
LEU A3166
ALA A3167
ALA A3174
ALA A3214
 None
 1.10A 1sa1C-3cmuA:
undetectable
1sa1D-3cmuA:
undetectable		 1sa1C-3cmuA:
12.85
1sa1D-3cmuA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 VAL A4143
LEU A4166
ALA A4167
ALA A4174
ALA A4214
 None
 1.10A 1sa1C-3cmuA:
undetectable
1sa1D-3cmuA:
undetectable		 1sa1C-3cmuA:
12.85
1sa1D-3cmuA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 VAL A5143
LEU A5166
ALA A5167
ALA A5174
ALA A5214
 None
 1.09A 1sa1C-3cmuA:
undetectable
1sa1D-3cmuA:
undetectable		 1sa1C-3cmuA:
12.85
1sa1D-3cmuA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		6 VAL A 475
ALA A 458
LEU A 467
ALA A 497
VAL A 499
ALA A 451
 None
 1.36A 1sa1C-3czeA:
undetectable
1sa1D-3czeA:
undetectable		 1sa1C-3czeA:
20.83
1sa1D-3czeA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1

(Cavia porcellus) 		PF00106
(adh_short) 		5 CYH A  78
LEU A  79
ALA A  83
MET A 110
ALA A  51
 None
 1.02A 1sa1C-3dwfA:
7.2
1sa1D-3dwfA:
7.4		 1sa1C-3dwfA:
20.82
1sa1D-3dwfA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoo METHYLISOCITRATE
LYASE

(Burkholderia
pseudomallei) 		PF13714
(PEP_mutase) 		5 LEU A 236
LEU A  86
VAL A  17
LYS A  12
ALA A  16
 None
 1.11A 1sa1C-3eooA:
undetectable
1sa1D-3eooA:
undetectable		 1sa1C-3eooA:
21.06
1sa1D-3eooA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 VAL A 782
LEU A 549
LEU A 562
ALA A 566
ALA A 482
 None
 1.09A 1sa1C-3fawA:
undetectable
1sa1D-3fawA:
undetectable		 1sa1C-3fawA:
19.67
1sa1D-3fawA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijf CYTIDINE DEAMINASE

(Mycobacterium
tuberculosis) 		PF00383
(dCMP_cyt_deam_1) 		5 LEU X   9
ALA X  77
LEU X  76
ALA X  57
ALA X  17
 None
 1.13A 1sa1C-3ijfX:
undetectable
1sa1D-3ijfX:
undetectable		 1sa1C-3ijfX:
14.93
1sa1D-3ijfX:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		6 LEU A 362
ALA A 366
LEU A 370
MET A 373
VAL A 237
ALA A 238
 None
 1.07A 1sa1C-3is5A:
undetectable
1sa1D-3is5A:
undetectable		 1sa1C-3is5A:
20.87
1sa1D-3is5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbb ALLOPHYCOCYANIN BETA
CHAIN

(Halomicronema
hongdechloris) 		PF00502
(Phycobilisome) 		5 LEU B 153
ALA B  92
LEU B  89
VAL B 141
ALA B  40
 None
 1.09A 1sa1C-3jbbB:
undetectable
1sa1D-3jbbB:
undetectable		 1sa1C-3jbbB:
18.14
1sa1D-3jbbB:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kje CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE
COMPLEX, ACCESSORY
PROTEIN COOC

(Carboxydothermus
hydrogenoformans) 		PF01656
(CbiA) 		5 VAL A 186
LEU A 129
ALA A 153
ALA A   4
VAL A 135
 None
 1.03A 1sa1C-3kjeA:
4.7
1sa1D-3kjeA:
4.8		 1sa1C-3kjeA:
20.27
1sa1D-3kjeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwk PUTATIVE NADH
DEHYDROGENASE/NAD(P)
H NITROREDUCTASE

(Bacteroides
thetaiotaomicron) 		PF00881
(Nitroreductase) 		5 VAL A  81
ALA A 105
LEU A 102
VAL A 144
ALA A 143
 None
 1.17A 1sa1C-3kwkA:
undetectable
1sa1D-3kwkA:
undetectable		 1sa1C-3kwkA:
18.36
1sa1D-3kwkA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		5 LEU A 360
ALA A 358
ALA A 284
VAL A 286
ALA A 324
 None
 1.12A 1sa1C-3lrkA:
undetectable
1sa1D-3lrkA:
undetectable		 1sa1C-3lrkA:
20.97
1sa1D-3lrkA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mk3 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Salmonella
enterica) 		no annotation 5 LEU A  60
ALA A  78
ALA A  68
VAL A 104
ALA A 105
 None
 1.19A 1sa1C-3mk3A:
undetectable
1sa1D-3mk3A:
undetectable		 1sa1C-3mk3A:
15.18
1sa1D-3mk3A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi) 		PF04264
(YceI) 		5 VAL A 182
LEU A 188
ALA A 186
LEU A  32
ALA A 133
 None
None
UQ8  A   1 ( 4.4A)
UQ8  A   1 (-4.3A)
UQ8  A   1 ( 3.9A)
 1.01A 1sa1C-3q34A:
undetectable
1sa1D-3q34A:
undetectable		 1sa1C-3q34A:
16.89
1sa1D-3q34A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)

(Leishmania
infantum) 		PF00215
(OMPdecase) 		5 VAL A  73
CYH A 245
LEU A 244
ALA A 241
ALA A  46
 None
 1.13A 1sa1C-3qw3A:
undetectable
1sa1D-3qw3A:
undetectable		 1sa1C-3qw3A:
18.79
1sa1D-3qw3A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT A
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J

(Escherichia
coli) 		PF00507
(Oxidored_q4)
no annotation 		5 LEU A  62
ALA A  66
LEU A  70
MET A  73
ALA J 155
 None
 1.05A 1sa1C-3rkoA:
undetectable
1sa1D-3rkoA:
undetectable		 1sa1C-3rkoA:
15.08
1sa1D-3rkoA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stt METHYLKETONE
SYNTHASE I

(Solanum
habrochaites) 		PF12697
(Abhydrolase_6) 		5 ALA A  87
LEU A  88
VAL A 132
LYS A 127
ALA A 131
 DKA  A 266 (-3.4A)
DKA  A 266 (-4.2A)
None
None
None
 1.16A 1sa1C-3sttA:
3.5
1sa1D-3sttA:
3.3		 1sa1C-3sttA:
21.75
1sa1D-3sttA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum) 		PF13378
(MR_MLE_C) 		5 VAL A 117
ALA A  64
LEU A  61
VAL A 107
ALA A 108
 None
 1.03A 1sa1C-3va8A:
3.4
1sa1D-3va8A:
3.4		 1sa1C-3va8A:
21.14
1sa1D-3va8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 LEU A  22
ALA A 447
LEU A 451
MET A 454
VAL A  30
 None
 1.00A 1sa1C-3zyxA:
undetectable
1sa1D-3zyxA:
undetectable		 1sa1C-3zyxA:
20.70
1sa1D-3zyxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8

(Homo sapiens) 		PF00400
(WD40) 		5 LEU B 261
ASN B 289
VAL B 211
LYS B 247
ALA B 205
 None
 1.20A 1sa1C-4a11B:
undetectable
1sa1D-4a11B:
undetectable		 1sa1C-4a11B:
21.88
1sa1D-4a11B:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A 213
ALA A 260
ALA A 296
VAL A 293
ALA A 300
 None
 1.08A 1sa1C-4ak9A:
3.6
1sa1D-4ak9A:
3.5		 1sa1C-4ak9A:
22.06
1sa1D-4ak9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II

(Mycobacterium
tuberculosis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 VAL A 250
LEU A  54
ALA A  53
LEU A  57
ALA A 151
 None
 1.20A 1sa1C-4apbA:
undetectable
1sa1D-4apbA:
undetectable		 1sa1C-4apbA:
23.58
1sa1D-4apbA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as5 INOSITOL
MONOPHOSPHATASE 1

(Mus musculus) 		PF00459
(Inositol_P) 		5 VAL A 193
LEU A 235
ALA A 252
ASN A 199
VAL A 148
 None
 1.12A 1sa1C-4as5A:
undetectable
1sa1D-4as5A:
undetectable		 1sa1C-4as5A:
22.03
1sa1D-4as5A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE,
IRON-SULFUR PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD) 		5 VAL B 243
CYH B  83
ALA B  88
ALA B  92
VAL B  53
 None
 1.00A 1sa1C-4c1nB:
undetectable
1sa1D-4c1nB:
undetectable		 1sa1C-4c1nB:
22.32
1sa1D-4c1nB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 LEU A 346
ALA A 349
LEU A  68
ASN A  70
ALA A 326
 None
 1.17A 1sa1C-4dykA:
undetectable
1sa1D-4dykA:
undetectable		 1sa1C-4dykA:
22.82
1sa1D-4dykA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		5 LEU A 352
ALA A 355
LEU A  74
ASN A  76
ALA A 332
 None
 1.17A 1sa1C-4dzhA:
undetectable
1sa1D-4dzhA:
undetectable		 1sa1C-4dzhA:
22.05
1sa1D-4dzhA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Burkholderia
vietnamiensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 412
ALA A 327
ASN A 413
VAL A 310
ALA A 312
 None
 1.15A 1sa1C-4f32A:
undetectable
1sa1D-4f32A:
undetectable		 1sa1C-4f32A:
23.01
1sa1D-4f32A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		5 LEU A  68
ALA A 164
LEU A 163
ASN A 167
ALA A 463
 None
 1.19A 1sa1C-4go4A:
undetectable
1sa1D-4go4A:
undetectable		 1sa1C-4go4A:
22.98
1sa1D-4go4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 VAL A 231
CYH A 212
LEU A 213
ALA A 239
ALA A 225
 None
 1.01A 1sa1C-4gvlA:
4.7
1sa1D-4gvlA:
4.8		 1sa1C-4gvlA:
21.51
1sa1D-4gvlA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx0 TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N)
PF07885
(Ion_trans_2) 		5 VAL A 231
CYH A 212
LEU A 213
ALA A 239
ALA A 225
 None
 1.00A 1sa1C-4gx0A:
5.5
1sa1D-4gx0A:
undetectable		 1sa1C-4gx0A:
23.78
1sa1D-4gx0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		5 LEU A 180
ALA A 177
LEU A 176
ASN A 172
VAL A 143
 None
 1.16A 1sa1C-4mydA:
undetectable
1sa1D-4mydA:
3.5		 1sa1C-4mydA:
20.26
1sa1D-4mydA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo2 CHLOROPHENOL-4-MONOO
XYGENASE

(Streptomyces
globisporus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		5 ALA A 402
LEU A 405
MET A 443
ALA A 327
ALA A 333
 None
 1.17A 1sa1C-4oo2A:
undetectable
1sa1D-4oo2A:
undetectable		 1sa1C-4oo2A:
21.60
1sa1D-4oo2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhr ALANINE RACEMASE

(Acinetobacter
baumannii) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ALA A  48
LEU A  17
ASN A  16
VAL A  33
ALA A  37
 None
None
None
LLP  A  34 ( 3.3A)
None
 0.98A 1sa1C-4qhrA:
undetectable
1sa1D-4qhrA:
undetectable		 1sa1C-4qhrA:
21.24
1sa1D-4qhrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A 537
ALA A 536
LEU A 535
ASN A 534
LYS A 476
 None
 1.18A 1sa1C-4rvwA:
undetectable
1sa1D-4rvwA:
undetectable		 1sa1C-4rvwA:
19.57
1sa1D-4rvwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ure CYCLOHEXANOL
DEHYDROGENASE

(Aromatoleum
aromaticum) 		PF13561
(adh_short_C2) 		5 ALA A 224
MET A   1
VAL A  32
LYS A   6
ALA A   8
 None
 1.03A 1sa1C-4ureA:
6.7
1sa1D-4ureA:
6.8		 1sa1C-4ureA:
21.54
1sa1D-4ureA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2i ESTERASE/LIPASE

(Thalassospira
sp. GB04J01) 		PF07859
(Abhydrolase_3) 		5 VAL A 112
ALA A 107
LEU A 103
ALA A 155
ALA A 181
 None
 1.18A 1sa1C-4v2iA:
2.9
1sa1D-4v2iA:
4.0		 1sa1C-4v2iA:
20.72
1sa1D-4v2iA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN

(Enterococcus
faecalis) 		PF00781
(DAGK_cat) 		6 VAL A 135
LEU A 103
ALA A  98
LEU A  97
ASN A 134
MET A 133
 None
 1.47A 1sa1C-4werA:
undetectable
1sa1D-4werA:
undetectable		 1sa1C-4werA:
21.79
1sa1D-4werA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		5 LEU A 127
ALA A 130
LEU A 112
ASN A 111
ALA A  90
 None
 1.13A 1sa1C-4yeiA:
undetectable
1sa1D-4yeiA:
undetectable		 1sa1C-4yeiA:
17.90
1sa1D-4yeiA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxx DTOR_6X35L

(synthetic
construct) 		no annotation 5 LEU A 133
ALA A 132
LEU A 143
LYS A 116
ALA A 118
 None
 1.10A 1sa1C-4yxxA:
undetectable
1sa1D-4yxxA:
undetectable		 1sa1C-4yxxA:
19.96
1sa1D-4yxxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2e T-CELL
DIFFERENTIATION
ANTIGEN CD6

(Homo sapiens) 		PF00530
(SRCR) 		5 ALA A  78
LEU A 127
ALA A 151
VAL A 153
ALA A  94
 None
 0.96A 1sa1C-5a2eA:
undetectable
1sa1D-5a2eA:
undetectable		 1sa1C-5a2eA:
19.14
1sa1D-5a2eA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 VAL A 269
ALA A 277
LEU A 282
ALA A 251
VAL A 195
 None
 1.05A 1sa1C-5ehkA:
undetectable
1sa1D-5ehkA:
undetectable		 1sa1C-5ehkA:
17.29
1sa1D-5ehkA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE

(Symbiobacterium
thermophilum) 		PF00282
(Pyridoxal_deC) 		5 ALA A 207
LEU A 172
ALA A 243
VAL A 241
ALA A 194
 None
 1.10A 1sa1C-5eueA:
undetectable
1sa1D-5eueA:
undetectable		 1sa1C-5eueA:
21.85
1sa1D-5eueA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6o PORPHOBILINOGEN
DEAMINASE

(Vibrio cholerae) 		no annotation 6 VAL A 202
LEU A 244
ASN A 241
MET A 240
ALA A 267
VAL A 278
 None
 1.29A 1sa1C-5h6oA:
undetectable
1sa1D-5h6oA:
undetectable		 1sa1C-5h6oA:
20.52
1sa1D-5h6oA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 393
ALA A 377
LEU A 374
ALA A 329
VAL A 333
 None
 1.16A 1sa1C-5imuA:
undetectable
1sa1D-5imuA:
undetectable		 1sa1C-5imuA:
18.40
1sa1D-5imuA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 ALA B1213
LEU B1200
ALA B1143
VAL B1139
ALA B1192
 None
 1.06A 1sa1C-5jpnB:
undetectable
1sa1D-5jpnB:
undetectable		 1sa1C-5jpnB:
20.00
1sa1D-5jpnB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 VAL A 466
ALA A 506
LEU A 505
ALA A 475
ALA A 539
 None
 1.17A 1sa1C-5mkkA:
undetectable
1sa1D-5mkkA:
undetectable		 1sa1C-5mkkA:
20.26
1sa1D-5mkkA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 ALA B 250
LEU B 255
ASN B 258
MET B 259
ALA B 316
 None
 1.12A 1sa1C-5n5nB:
50.5
1sa1D-5n5nB:
52.9		 1sa1C-5n5nB:
40.88
1sa1D-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 CYH B 241
LEU B 242
LEU B 252
VAL B 318
ALA B 354
 None
 1.01A 1sa1C-5n5nB:
50.5
1sa1D-5n5nB:
52.9		 1sa1C-5n5nB:
40.88
1sa1D-5n5nB:
97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tch TRYPTOPHAN SYNTHASE
BETA CHAIN

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		6 VAL B 215
LEU B 139
ALA B 136
LEU B 106
ASN B 104
ALA B 112
 None
 1.42A 1sa1C-5tchB:
undetectable
1sa1D-5tchB:
undetectable		 1sa1C-5tchB:
23.20
1sa1D-5tchB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2i GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		5 LEU A 164
ALA A 199
LEU A 260
VAL A  35
ALA A 167
 None
 1.02A 1sa1C-5v2iA:
undetectable
1sa1D-5v2iA:
undetectable		 1sa1C-5v2iA:
20.39
1sa1D-5v2iA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Burkholderia
vietnamiensis) 		PF00171
(Aldedh) 		5 VAL A 238
LEU A 249
ALA A 246
LEU A 245
ALA A 152
 None
 1.13A 1sa1C-5vbfA:
undetectable
1sa1D-5vbfA:
undetectable		 1sa1C-5vbfA:
23.12
1sa1D-5vbfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 VAL B 892
LEU B 400
ALA B 403
LEU B 405
ALA B 838
 None
 1.19A 1sa1C-5vniB:
4.0
1sa1D-5vniB:
4.3		 1sa1C-5vniB:
20.53
1sa1D-5vniB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF

(Shewanella
oneidensis) 		no annotation 5 LEU B 118
ALA B  32
LEU B  31
VAL B 125
ALA B 126
 None
 1.18A 1sa1C-5vrfB:
undetectable
1sa1D-5vrfB:
undetectable		 1sa1C-5vrfB:
10.93
1sa1D-5vrfB:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 5 CYH A 622
ALA A 625
LEU A 627
VAL A 535
ALA A 534
 None
 1.13A 1sa1C-5wdxA:
undetectable
1sa1D-5wdxA:
undetectable		 1sa1C-5wdxA:
21.00
1sa1D-5wdxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Homo sapiens) 		no annotation 5 LEU A 138
ALA A 169
ASN A 228
ALA A 185
ALA A 146
 None
 1.15A 1sa1C-5wp6A:
3.0
1sa1D-5wp6A:
undetectable		 1sa1C-5wp6A:
11.65
1sa1D-5wp6A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wte VP3

(Hepatovirus A) 		PF00073
(Rhv) 		5 VAL C 224
LEU C 231
ALA C 228
LEU C 115
ALA C 100
 None
 1.17A 1sa1C-5wteC:
undetectable
1sa1D-5wteC:
undetectable		 1sa1C-5wteC:
18.78
1sa1D-5wteC:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 5 VAL C 609
LEU C 500
ALA C 567
LEU C 564
ALA C 506
 None
 1.05A 1sa1C-5x6xC:
undetectable
1sa1D-5x6xC:
undetectable		 1sa1C-5x6xC:
14.07
1sa1D-5x6xC:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bc5 AAC 3-VI PROTEIN

(Enterobacter
cloacae) 		no annotation 5 VAL A 185
ALA A 166
LEU A 169
VAL A 194
ALA A 193
 None
 1.11A 1sa1C-6bc5A:
undetectable
1sa1D-6bc5A:
undetectable		 1sa1C-6bc5A:
11.92
1sa1D-6bc5A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cyz HOMOSERINE KINASE

(Mycobacteroides
abscessus) 		no annotation 5 VAL A 251
LEU A  22
LEU A 272
ALA A 270
ALA A 267
 None
 1.17A 1sa1C-6cyzA:
undetectable
1sa1D-6cyzA:
undetectable		 1sa1C-6cyzA:
11.42
1sa1D-6cyzA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Sus scrofa) 		no annotation 5 LEU B 318
ALA B 339
LEU B 343
MET B 347
VAL B 267
 None
 1.14A 1sa1C-6exvB:
undetectable
1sa1D-6exvB:
undetectable		 1sa1C-6exvB:
11.40
1sa1D-6exvB:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD

(Acetobacterium
woodii) 		no annotation 5 VAL B 112
CYH B  74
LEU B  75
ALA B  79
ALA B   7
 None
 1.02A 1sa1C-6fahB:
undetectable
1sa1D-6fahB:
undetectable		 1sa1C-6fahB:
10.73
1sa1D-6fahB:
12.06