SIMILAR PATTERNS OF AMINO ACIDS FOR 1S9Q_B_CHDB500_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0n PROTEIN (CSDB
PROTEIN)

(Escherichia
coli) 		PF00266
(Aminotran_5) 		4 LEU A 198
VAL A 199
ILE A 170
TRP A 130
 None
 1.40A 1s9qB-1c0nA:
0.0		 1s9qB-1c0nA:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 354
VAL A 355
ILE A 358
TRP A 383
 None
 0.47A 1s9qB-1pcgA:
26.8		 1s9qB-1pcgA:
35.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE ALPHA
SUBUNIT

(Thermus
thermophilus) 		PF00676
(E1_dh) 		4 LEU A 262
VAL A 263
ILE A 200
TRP A 183
 None
 1.26A 1s9qB-1umbA:
undetectable		 1s9qB-1umbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxt HYPOTHETICAL PROTEIN
FLJ21522

(Homo sapiens) 		PF00018
(SH3_1) 		4 LEU A  59
VAL A  12
ILE A  58
TRP A  42
 None
 1.38A 1s9qB-1wxtA:
undetectable		 1s9qB-1wxtA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		4 LEU A 604
VAL A 601
ILE A 623
TRP A 619
 None
 1.49A 1s9qB-1x9dA:
0.0		 1s9qB-1x9dA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xuq SUPEROXIDE DISMUTASE

(Bacillus
anthracis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 LEU A  90
VAL A 190
ILE A  89
TRP A  87
 None
 1.32A 1s9qB-1xuqA:
0.2		 1s9qB-1xuqA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 LEU A 405
VAL A 342
ILE A 406
TRP A 474
 None
 1.47A 1s9qB-2bihA:
undetectable		 1s9qB-2bihA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ce9 TRANSDUCIN-LIKE
ENHANCER PROTEIN 1

(Homo sapiens) 		PF00400
(WD40) 		4 LEU A 554
VAL A 547
ILE A 546
TRP A 601
 None
 1.28A 1s9qB-2ce9A:
undetectable		 1s9qB-2ce9A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csg PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07350
(DUF1479) 		4 LEU A 266
VAL A 359
ILE A 188
TRP A 102
 None
 1.49A 1s9qB-2csgA:
undetectable		 1s9qB-2csgA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		4 LEU A 668
VAL A 664
ILE A 665
TRP A 464
 None
 1.43A 1s9qB-2d3iA:
0.2		 1s9qB-2d3iA:
16.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 276
VAL A 277
ILE A 280
TRP A 305
 OHT  A 500 (-4.9A)
None
None
None
 0.37A 1s9qB-2gpvA:
34.4		 1s9qB-2gpvA:
99.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 LEU A 282
VAL A 280
ILE A 381
TRP A 369
 None
 1.38A 1s9qB-2jisA:
undetectable		 1s9qB-2jisA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqa CALPAIN 8

(Homo sapiens) 		PF00648
(Peptidase_C2) 		4 LEU A 281
VAL A 269
ILE A 282
TRP A 297
 None
 1.27A 1s9qB-2nqaA:
undetectable		 1s9qB-2nqaA:
23.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 354
VAL A 355
ILE A 358
TRP A 383
 None
 0.46A 1s9qB-2ocfA:
27.0		 1s9qB-2ocfA:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 LEU A 417
VAL A 418
ILE A 416
TRP A 401
 None
 1.38A 1s9qB-2okjA:
undetectable		 1s9qB-2okjA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p67 LAO/AO TRANSPORT
SYSTEM KINASE

(Escherichia
coli) 		PF03308
(ArgK) 		4 LEU A 196
VAL A 198
ILE A 197
TRP A 231
 None
 1.19A 1s9qB-2p67A:
undetectable		 1s9qB-2p67A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xs6 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA

(Homo sapiens) 		PF00620
(RhoGAP) 		4 LEU A 131
VAL A 132
ILE A 135
TRP A 165
 None
 1.47A 1s9qB-2xs6A:
undetectable		 1s9qB-2xs6A:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 LEU A 324
VAL A 325
ILE A 326
TRP A 373
 None
 1.45A 1s9qB-2xtsA:
undetectable		 1s9qB-2xtsA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		4 LEU A 206
VAL A 169
ILE A 167
TRP A 190
 None
 1.08A 1s9qB-2xyqA:
undetectable		 1s9qB-2xyqA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		4 LEU A 230
VAL A  96
ILE A  94
TRP A 228
 None
 1.01A 1s9qB-2zq5A:
undetectable		 1s9qB-2zq5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Bos taurus) 		PF06052
(3-HAO) 		4 LEU A 102
VAL A 103
ILE A 104
TRP A 231
 None
 1.30A 1s9qB-3fe5A:
undetectable		 1s9qB-3fe5A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3s GCN5-RELATED
N-ACETYLTRANSFERASE

(Streptococcus
suis) 		PF12746
(GNAT_acetyltran) 		4 LEU A  74
VAL A  75
ILE A  73
TRP A 247
 None
 1.32A 1s9qB-3g3sA:
undetectable		 1s9qB-3g3sA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 LEU A 449
VAL A 448
ILE A 433
TRP A 431
 None
 1.16A 1s9qB-3mi6A:
undetectable		 1s9qB-3mi6A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 LEU A 412
VAL A 413
ILE A 331
TRP A 410
 None
 1.31A 1s9qB-3penA:
undetectable		 1s9qB-3penA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE

(Yersinia pestis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 311
VAL A 304
ILE A 312
TRP A 403
 None
 1.36A 1s9qB-3pyzA:
undetectable		 1s9qB-3pyzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r24 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		4 LEU A 206
VAL A 169
ILE A 167
TRP A 190
 None
 1.12A 1s9qB-3r24A:
undetectable		 1s9qB-3r24A:
28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbn DNA MISMATCH REPAIR
PROTEIN MLH1

(Homo sapiens) 		PF16413
(Mlh1_C) 		4 LEU A 148
VAL A 145
ILE A 144
TRP A 199
 None
 1.36A 1s9qB-3rbnA:
undetectable		 1s9qB-3rbnA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3w ENOYL-COA HYDRATASE

(Mycolicibacterium
thermoresistibile) 		PF00378
(ECH_1) 		4 LEU A  67
VAL A  66
ILE A  65
TRP A 110
 None
 1.35A 1s9qB-3t3wA:
undetectable		 1s9qB-3t3wA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		4 LEU A 213
VAL A 240
ILE A 211
TRP A 114
 None
 1.22A 1s9qB-3vssA:
undetectable		 1s9qB-3vssA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		4 LEU A 303
VAL A 302
ILE A 317
TRP A 350
 None
 1.28A 1s9qB-4bhdA:
undetectable		 1s9qB-4bhdA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffb PROTEIN STU2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU C  79
VAL C  77
ILE C  76
TRP C 103
 None
 1.18A 1s9qB-4ffbC:
undetectable		 1s9qB-4ffbC:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gsl AUTOPHAGY-RELATED
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF03986
(Autophagy_N)
PF03987
(Autophagy_act_C)
PF10381
(Autophagy_C) 		4 LEU C 291
VAL C 289
ILE C 288
TRP C  47
 None
 1.11A 1s9qB-4gslC:
undetectable		 1s9qB-4gslC:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb7 ENDONUCLEASE 8-LIKE
L720

(Acanthamoeba
polyphaga
mimivirus) 		PF06831
(H2TH) 		4 LEU A 100
VAL A  99
ILE A  98
TRP A  45
 None
 1.26A 1s9qB-4mb7A:
undetectable		 1s9qB-4mb7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		4 LEU A 291
VAL A 292
ILE A 295
TRP A 320
 None
 0.80A 1s9qB-4n1yA:
27.9		 1s9qB-4n1yA:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis) 		PF05690
(ThiG) 		4 LEU A  27
VAL A  28
ILE A  26
TRP A  14
 None
 1.39A 1s9qB-4n6fA:
undetectable		 1s9qB-4n6fA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 4 LEU B 361
VAL B 362
ILE B 378
TRP B 384
 None
 1.45A 1s9qB-4tqoB:
undetectable		 1s9qB-4tqoB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uc3 TRANSLOCATOR PROTEIN
TSPO

(Rhodobacter
sphaeroides) 		PF03073
(TspO_MBR) 		4 LEU A 133
VAL A 130
ILE A 134
TRP A 108
 None
None
YZY  A 203 ( 4.9A)
OLC  A 202 (-3.7A)
 1.09A 1s9qB-4uc3A:
undetectable		 1s9qB-4uc3A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU A 246
VAL A 245
ILE A 244
TRP A 269
 None
 1.21A 1s9qB-4zk3A:
undetectable		 1s9qB-4zk3A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 LEU A 733
VAL A 711
ILE A 709
TRP A 727
 None
 1.29A 1s9qB-4zxiA:
undetectable		 1s9qB-4zxiA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans) 		no annotation 4 LEU A 125
VAL A 126
ILE A  21
TRP A 111
 None
 1.36A 1s9qB-5ah0A:
undetectable		 1s9qB-5ah0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwy PHOSPHATIDYLGLYCEROP
HOSPHATASE B

(Escherichia
coli) 		PF01569
(PAP2) 		4 LEU A 217
VAL A 214
ILE A 218
TRP A 220
 None
 1.48A 1s9qB-5jwyA:
3.7		 1s9qB-5jwyA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Legionella
pneumophila) 		PF00290
(Trp_syntA) 		4 LEU A 128
VAL A 129
ILE A 127
TRP A 143
 None
 0.99A 1s9qB-5k9xA:
undetectable		 1s9qB-5k9xA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		4 LEU A 604
VAL A 601
ILE A 623
TRP A 619
 None
 1.48A 1s9qB-5kijA:
undetectable		 1s9qB-5kijA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n57 SUPEROXIDE DISMUTASE

(Staphylococcus
aureus) 		no annotation 4 LEU A  88
VAL A 186
ILE A  87
TRP A  85
 None
 1.40A 1s9qB-5n57A:
undetectable		 1s9qB-5n57A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocy ACPA E4 FAB FRAGMENT
- HEAVY CHAIN
ACPA E4 FAB FRAGMENT
- LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 LEU L  47
VAL L  48
ILE L  49
TRP H 106
 None
 1.04A 1s9qB-5ocyL:
undetectable		 1s9qB-5ocyL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t11 UNCHARACTERIZED
PROTEIN

(Paraburkholderia
phytofirmans) 		PF13036
(LpoB) 		4 LEU A 117
VAL A  91
ILE A 118
TRP A 127
 None
 1.47A 1s9qB-5t11A:
undetectable		 1s9qB-5t11A:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 306
VAL A 307
ILE A 310
TRP A 335
 None
 0.56A 1s9qB-5toaA:
27.8		 1s9qB-5toaA:
34.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 LEU B 151
VAL B 149
ILE B 153
TRP B 190
 None
 1.48A 1s9qB-5up2B:
undetectable		 1s9qB-5up2B:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn3 ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 LEU G  86
VAL G  85
ILE G  84
TRP G  45
 None
 1.44A 1s9qB-5vn3G:
undetectable		 1s9qB-5vn3G:
16.96