SIMILAR PATTERNS OF AMINO ACIDS FOR 1S9Q_A_CHDA459_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1amo | NADPH-CYTOCHROMEP450 REDUCTASE (Rattusnorvegicus) |
PF00175(NAD_binding_1)PF00258(Flavodoxin_1)PF00667(FAD_binding_1) | 4 | LEU A 330VAL A 331ILE A 334TYR A 478 | NoneNoneNoneFAD A 750 (-3.4A) | 0.69A | 1s9qA-1amoA:undetectable | 1s9qA-1amoA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ati | GLYCYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 4 | LEU A 390VAL A 389ILE A 388TYR A 296 | None | 1.03A | 1s9qA-1atiA:0.1 | 1s9qA-1atiA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cs1 | PROTEIN(CYSTATHIONINEGAMMA-SYNTHASE) (Escherichiacoli) |
PF01053(Cys_Met_Meta_PP) | 4 | ASP A 173LEU A 193VAL A 192ILE A 212 | LLP A 198 ( 3.0A)NoneNoneNone | 1.03A | 1s9qA-1cs1A:undetectable | 1s9qA-1cs1A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g6q | HNRNP ARGININEN-METHYLTRANSFERASE (Saccharomycescerevisiae) |
PF06325(PrmA) | 4 | ASP 1 64LEU 1 63VAL 1 62ILE 1 61 | None | 0.97A | 1s9qA-1g6q1:undetectable | 1s9qA-1g6q1:22.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | ASP A 351LEU A 354VAL A 355ILE A 358TRP A 383 | None | 0.72A | 1s9qA-1pcgA:27.0 | 1s9qA-1pcgA:35.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8i | DNA POLYMERASE II (Escherichiacoli) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | ASP A 335LEU A 338VAL A 339ILE A 342 | None | 0.26A | 1s9qA-1q8iA:0.0 | 1s9qA-1q8iA:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qr7 | PHENYLALANINE-REGULATED3-DEOXY-D-ARABINO-HEPTULOSONATE-7-PHOSPHATE SYNTHASE (Escherichiacoli) |
PF00793(DAHP_synth_1) | 4 | VAL A 262ILE A 297TRP A 159TYR A 94 | NoneNoneNonePEP A1352 (-4.3A) | 0.96A | 1s9qA-1qr7A:undetectable | 1s9qA-1qr7A:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qv9 | F420-DEPENDENTMETHYLENETETRAHYDROMETHANOPTERINDEHYDROGENASE (Methanopyruskandleri) |
PF01993(MTD) | 4 | ASP A 99LEU A 118VAL A 119ILE A 117 | None | 1.03A | 1s9qA-1qv9A:0.0 | 1s9qA-1qv9A:25.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sus | CAFFEOYL-COAO-METHYLTRANSFERASE (Medicago sativa) |
PF01596(Methyltransf_3) | 4 | ASP A 178LEU A 179VAL A 180ILE A 160 | None | 0.99A | 1s9qA-1susA:undetectable | 1s9qA-1susA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t8q | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE,PERIPLASMIC (Escherichiacoli) |
PF03009(GDPD) | 4 | ASP A 65LEU A 66VAL A 67ILE A 185 | MG A1601 ( 2.7A)NoneNoneNone | 0.89A | 1s9qA-1t8qA:undetectable | 1s9qA-1t8qA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tuj | ODORANT BINDINGPROTEIN ASP2 (Apis mellifera) |
PF01395(PBP_GOBP) | 4 | ASP A 85LEU A 88VAL A 89ILE A 92 | None | 0.74A | 1s9qA-1tujA:undetectable | 1s9qA-1tujA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uwv | 23S RRNA(URACIL-5-)-METHYLTRANSFERASE RUMA (Escherichiacoli) |
PF01938(TRAM)PF05958(tRNA_U5-meth_tr) | 4 | ASP A 292LEU A 361VAL A 360ILE A 384 | None | 0.90A | 1s9qA-1uwvA:undetectable | 1s9qA-1uwvA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdv | HYPOTHETICAL PROTEINAPE2540 (Aeropyrumpernix) |
PF04073(tRNA_edit) | 4 | ASP A 50LEU A 49VAL A 48ILE A 47 | None | 0.90A | 1s9qA-1wdvA:undetectable | 1s9qA-1wdvA:21.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xb7 | STEROID HORMONERECEPTOR ERR1 (Homo sapiens) |
PF00104(Hormone_recep) | 4 | ASP A 329VAL A 333ILE A 336TRP A 361 | None | 0.93A | 1s9qA-1xb7A:28.7 | 1s9qA-1xb7A:60.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3i | SIMILAR TORAD54-LIKE (Danio rerio) |
PF00176(SNF2_N)PF00271(Helicase_C) | 4 | ASP X 246LEU X 249VAL X 250ILE X 253 | None | 0.46A | 1s9qA-1z3iX:undetectable | 1s9qA-1z3iX:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zit | TRANSCRIPTIONALREGULATOR (NTRCFAMILY) (Aquifexaeolicus) |
PF00072(Response_reg) | 4 | ASP A 52LEU A 51VAL A 50ILE A 49 | None | 0.96A | 1s9qA-1zitA:undetectable | 1s9qA-1zitA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zv9 | CELLULOSOMALSCAFFOLDIN ADAPTORPROTEIN B (Acetivibriocellulolyticus) |
PF00963(Cohesin) | 4 | ASP A 12LEU A 11VAL A 10ILE A 9 | None | 0.98A | 1s9qA-1zv9A:undetectable | 1s9qA-1zv9A:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a14 | INDOLETHYLAMINEN-METHYLTRANSFERASE (Homo sapiens) |
PF01234(NNMT_PNMT_TEMT) | 4 | ASP A 61LEU A 161VAL A 160TYR A 25 | NoneNoneNoneSAH A4001 (-4.4A) | 1.02A | 1s9qA-2a14A:undetectable | 1s9qA-2a14A:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a9f | PUTATIVE MALICENZYME((S)-MALATE:NAD+OXIDOREDUCTASE(DECARBOXYLATING)) (Streptococcuspyogenes) |
PF00390(malic)PF03949(Malic_M) | 4 | ASP A 113LEU A 112VAL A 111ILE A 110 | None | 0.91A | 1s9qA-2a9fA:undetectable | 1s9qA-2a9fA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aky | ADENYLATE KINASE (Saccharomycescerevisiae) |
PF00406(ADK)PF05191(ADK_lid) | 4 | ASP A 122LEU A 125VAL A 126ILE A 129 | None | 0.69A | 1s9qA-2akyA:undetectable | 1s9qA-2akyA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d39 | FICOLIN-1 (Homo sapiens) |
PF00147(Fibrinogen_C) | 4 | ASP A 207LEU A 208VAL A 209TRP A 306 | None | 0.86A | 1s9qA-2d39A:undetectable | 1s9qA-2d39A:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d39 | FICOLIN-1 (Homo sapiens) |
PF00147(Fibrinogen_C) | 4 | LEU A 208VAL A 209TRP A 306TYR A 220 | None | 1.00A | 1s9qA-2d39A:undetectable | 1s9qA-2d39A:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dmh | MYOFERLIN (Homo sapiens) |
PF00168(C2) | 4 | ASP A 126LEU A 127VAL A 128ILE A 129 | None | 0.91A | 1s9qA-2dmhA:undetectable | 1s9qA-2dmhA:21.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gpv | ESTROGEN-RELATEDRECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | ASP A 273LEU A 276VAL A 277ILE A 280TRP A 305TYR A 436 | OHT A 500 (-3.1A)OHT A 500 (-4.9A)NoneNoneNoneNone | 0.56A | 1s9qA-2gpvA:35.2 | 1s9qA-2gpvA:99.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gvk | HEME PEROXIDASE (Bacteroidesthetaiotaomicron) |
PF04261(Dyp_perox) | 4 | ASP A 107LEU A 108VAL A 28ILE A 27 | NoneNoneEDO A 322 ( 4.5A)None | 1.03A | 1s9qA-2gvkA:undetectable | 1s9qA-2gvkA:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2icu | HYPOTHETICAL PROTEINYEDK (Escherichiacoli) |
PF02586(SRAP) | 4 | ASP A 160LEU A 163VAL A 164TRP A 110 | None | 0.76A | 1s9qA-2icuA:undetectable | 1s9qA-2icuA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ido | DNA POLYMERASE IIIEPSILON SUBUNIT (Escherichiacoli) |
PF00929(RNase_T) | 4 | ASP A 12LEU A 11VAL A 10ILE A 9 | MN A1001 (-2.6A)NoneNoneNone | 0.99A | 1s9qA-2idoA:undetectable | 1s9qA-2idoA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iip | NICOTINAMIDEN-METHYLTRANSFERASE (Homo sapiens) |
PF01234(NNMT_PNMT_TEMT) | 4 | ASP A 61LEU A 161VAL A 160TYR A 25 | NoneNoneNoneSAH A4001 (-4.4A) | 0.91A | 1s9qA-2iipA:undetectable | 1s9qA-2iipA:26.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jk9 | SPRYDOMAIN-CONTAININGSOCS BOX PROTEIN 1 (Homo sapiens) |
PF00622(SPRY) | 4 | ASP A 143LEU A 144ILE A 172TRP A 104 | None | 0.95A | 1s9qA-2jk9A:undetectable | 1s9qA-2jk9A:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oap | TYPE II SECRETIONSYSTEM PROTEIN (Archaeoglobusfulgidus) |
PF00437(T2SSE) | 4 | ASP 1 173LEU 1 172VAL 1 171ILE 1 170 | None | 0.96A | 1s9qA-2oap1:undetectable | 1s9qA-2oap1:20.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocf | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 4 | ASP A 351LEU A 354ILE A 358TRP A 383 | None | 0.86A | 1s9qA-2ocfA:27.2 | 1s9qA-2ocfA:32.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocf | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 4 | LEU A 354VAL A 355ILE A 358TRP A 383 | None | 0.41A | 1s9qA-2ocfA:27.2 | 1s9qA-2ocfA:32.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2plj | LYSINE/ORNITHINEDECARBOXYLASE (Vibriovulnificus) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 4 | ASP A 358LEU A 359VAL A 360ILE A 361 | None | 0.84A | 1s9qA-2pljA:undetectable | 1s9qA-2pljA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q7b | ACETYLTRANSFERASE,GNAT FAMILY (Streptococcusagalactiae) |
PF00583(Acetyltransf_1) | 4 | ASP A 118LEU A 117VAL A 116ILE A 115 | FLC A 164 (-3.2A)NoneNoneNone | 0.80A | 1s9qA-2q7bA:undetectable | 1s9qA-2q7bA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qe8 | UNCHARACTERIZEDPROTEIN (Trichormusvariabilis) |
PF03022(MRJP) | 4 | ASP A 202LEU A 201VAL A 200ILE A 199 | None | 0.89A | 1s9qA-2qe8A:undetectable | 1s9qA-2qe8A:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rch | CYTOCHROME P450 74A (Arabidopsisthaliana) |
PF00067(p450) | 4 | ASP A 398LEU A 399VAL A 400ILE A 401 | None | 0.99A | 1s9qA-2rchA:undetectable | 1s9qA-2rchA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wnp | FICOLIN-1 (Homo sapiens) |
PF00147(Fibrinogen_C) | 4 | LEU F 179VAL F 180TRP F 277TYR F 191 | None | 0.89A | 1s9qA-2wnpF:undetectable | 1s9qA-2wnpF:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wp8 | EXOSOME COMPLEXEXONUCLEASE DIS3 (Saccharomycescerevisiae) |
PF00773(RNB)PF13638(PIN_4)PF17215(Rrp44_S1)PF17216(Rrp44_CSD1) | 4 | ASP J 335VAL J 333ILE J 332TYR J 462 | None | 0.94A | 1s9qA-2wp8J:undetectable | 1s9qA-2wp8J:13.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b83 | TEN-D3 (Homo sapiens) |
PF00041(fn3) | 4 | ASP A 48LEU A 32VAL A 33ILE A 71 | None | 0.97A | 1s9qA-3b83A:undetectable | 1s9qA-3b83A:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cah | AGGLUTININ II (Sambucus nigra) |
PF00652(Ricin_B_lectin) | 4 | ASP A 114LEU A 97VAL A 98ILE A 91 | NAG A 258 ( 3.7A)NoneNoneNone | 0.98A | 1s9qA-3cahA:undetectable | 1s9qA-3cahA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cia | COLD-ACTIVEAMINOPEPTIDASE (Colwelliapsychrerythraea) |
PF01433(Peptidase_M1)PF09127(Leuk-A4-hydro_C) | 4 | ASP A 92LEU A 93VAL A 94ILE A 95 | None | 0.92A | 1s9qA-3ciaA:undetectable | 1s9qA-3ciaA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6n | ASPARTATECARBAMOYLTRANSFERASE (Aquifexaeolicus) |
PF00185(OTCace)PF02729(OTCace_N) | 4 | LEU B 150VAL B 149ILE B 175TYR B 230 | None | 0.75A | 1s9qA-3d6nB:undetectable | 1s9qA-3d6nB:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dkz | THIOESTERASESUPERFAMILY PROTEIN (Bordetellaparapertussis) |
PF03061(4HBT) | 4 | ASP A 123LEU A 124VAL A 125ILE A 126 | None | 0.88A | 1s9qA-3dkzA:undetectable | 1s9qA-3dkzA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g12 | PUTATIVELACTOYLGLUTATHIONELYASE (Bdellovibriobacteriovorus) |
no annotation | 4 | ASP A 107LEU A 106VAL A 105ILE A 104 | None | 0.93A | 1s9qA-3g12A:undetectable | 1s9qA-3g12A:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4c | TRANSCRIPTION FACTORTFIIB-LIKE (Trypanosomabrucei) |
no annotation | 4 | ASP A 202LEU A 205VAL A 206ILE A 209 | None | 0.55A | 1s9qA-3h4cA:undetectable | 1s9qA-3h4cA:25.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn7 | UDP-N-ACETYLMURAMATE-L-ALANINE LIGASE (Psychrobacterarcticus) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 4 | ASP A 364LEU A 369VAL A 370ILE A 479 | None | 0.86A | 1s9qA-3hn7A:undetectable | 1s9qA-3hn7A:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpd | HYDROXYETHYLTHIAZOLEKINASE (Pyrococcushorikoshii) |
PF02110(HK) | 4 | ASP A 92LEU A 91VAL A 90ILE A 89 | None | 1.01A | 1s9qA-3hpdA:undetectable | 1s9qA-3hpdA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib7 | ICC PROTEIN (Mycobacteriumtuberculosis) |
PF00149(Metallophos) | 4 | ASP A 133LEU A 132VAL A 131ILE A 130 | None | 1.02A | 1s9qA-3ib7A:undetectable | 1s9qA-3ib7A:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3in6 | FMN-BINDING PROTEIN (Syntrophomonaswolfei) |
no annotation | 4 | ASP A 104LEU A 132VAL A 133ILE A 60 | None | 0.81A | 1s9qA-3in6A:undetectable | 1s9qA-3in6A:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j1c | CHAPERONIN ALPHASUBUNIT (Acidianustengchongensis) |
PF00118(Cpn60_TCP1) | 4 | ASP A 229LEU A 228VAL A 227ILE A 226 | None | 1.02A | 1s9qA-3j1cA:undetectable | 1s9qA-3j1cA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kw0 | CYSTEINE PEPTIDASE (Bacillus cereus) |
PF05708(Peptidase_C92) | 4 | ASP A 68VAL A 136ILE A 139TYR A 79 | LYS A 201 (-2.8A)NoneNoneNone | 0.89A | 1s9qA-3kw0A:undetectable | 1s9qA-3kw0A:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8q | CELLULOSOMALSCAFFOLDIN ADAPTORPROTEIN B (Acetivibriocellulolyticus) |
PF00963(Cohesin) | 4 | ASP A 12LEU A 11VAL A 10ILE A 9 | None | 0.95A | 1s9qA-3l8qA:undetectable | 1s9qA-3l8qA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ndn | O-SUCCINYLHOMOSERINESULFHYDRYLASE (Mycobacteriumtuberculosis) |
PF01053(Cys_Met_Meta_PP) | 4 | ASP A 347LEU A 358VAL A 359ILE A 387 | None | 0.90A | 1s9qA-3ndnA:undetectable | 1s9qA-3ndnA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q80 | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATECYTIDYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF01128(IspD) | 4 | ASP A 193LEU A 196VAL A 197ILE A 200 | None | 0.86A | 1s9qA-3q80A:undetectable | 1s9qA-3q80A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0z | D-SERINE DEHYDRATASE (Salmonellaenterica) |
PF00291(PALP) | 4 | ASP A 16LEU A 17VAL A 18ILE A 327 | None | 0.88A | 1s9qA-3r0zA:undetectable | 1s9qA-3r0zA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r9p | ACKA (Mycobacteriumavium) |
PF00871(Acetate_kinase) | 4 | ASP A 343LEU A 342VAL A 341ILE A 340 | None | 1.02A | 1s9qA-3r9pA:undetectable | 1s9qA-3r9pA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ss7 | D-SERINE DEHYDRATASE (Escherichiacoli) |
PF00291(PALP) | 4 | ASP X 18LEU X 19VAL X 20ILE X 329 | None | 1.01A | 1s9qA-3ss7X:undetectable | 1s9qA-3ss7X:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tlx | ADENYLATE KINASE 2 (Plasmodiumfalciparum) |
PF00406(ADK)PF05191(ADK_lid) | 4 | ASP A 145LEU A 148VAL A 149ILE A 152 | None | 0.52A | 1s9qA-3tlxA:undetectable | 1s9qA-3tlxA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wry | TM-1 PROTEIN (Solanumlycopersicum) |
PF06792(UPF0261) | 4 | ASP A 255LEU A 256VAL A 257ILE A 262 | None | 1.02A | 1s9qA-3wryA:undetectable | 1s9qA-3wryA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ci6 | PROTEIN KINASE YOPO (Yersiniaenterocolitica) |
PF00069(Pkinase)PF09632(Rac1) | 4 | ASP B 212LEU B 157VAL B 158ILE B 147 | None | 0.93A | 1s9qA-4ci6B:undetectable | 1s9qA-4ci6B:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvq | GLUTAMATE-PYRUVATEAMINOTRANSFERASEALAA (Escherichiacoli) |
PF00155(Aminotran_1_2) | 4 | ASP A 52LEU A 55VAL A 56ILE A 59 | None | 0.69A | 1s9qA-4cvqA:undetectable | 1s9qA-4cvqA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eku | PROTEIN-TYROSINEKINASE 2-BETA (Homo sapiens) |
PF00373(FERM_M) | 4 | ASP A 278LEU A 279VAL A 280ILE A 281 | None | 0.83A | 1s9qA-4ekuA:undetectable | 1s9qA-4ekuA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4em6 | GLUCOSE-6-PHOSPHATEISOMERASE (Brucellamelitensis) |
no annotation | 4 | ASP D 337VAL D 403ILE D 472TYR D 171 | None | 0.99A | 1s9qA-4em6D:undetectable | 1s9qA-4em6D:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h6q | PROLINEDEHYDROGENASE (Deinococcusradiodurans) |
PF01619(Pro_dh) | 4 | ASP A 60VAL A 95ILE A 132TYR A 193 | NoneNoneNoneFAD A2001 (-4.1A) | 0.75A | 1s9qA-4h6qA:undetectable | 1s9qA-4h6qA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hd1 | SQUALENE SYNTHASEHPNC (Alicyclobacillusacidocaldarius) |
PF00494(SQS_PSY) | 4 | LEU A 139VAL A 140ILE A 143TYR A 69 | None | 0.48A | 1s9qA-4hd1A:undetectable | 1s9qA-4hd1A:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hpm | BCL-6COREPRESSOR-LIKEPROTEIN 1 (Homo sapiens) |
PF16553(PUFD) | 4 | LEU A1689VAL A1690ILE A1648TYR A1657 | None | 1.02A | 1s9qA-4hpmA:undetectable | 1s9qA-4hpmA:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jqp | 4-HYDROXYTHREONINE-4-PHOSPHATEDEHYDROGENASE (Paraburkholderiaphymatum) |
PF04166(PdxA) | 4 | ASP A 87LEU A 49VAL A 50ILE A 20 | None | 0.99A | 1s9qA-4jqpA:undetectable | 1s9qA-4jqpA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jqp | 4-HYDROXYTHREONINE-4-PHOSPHATEDEHYDROGENASE (Paraburkholderiaphymatum) |
PF04166(PdxA) | 4 | LEU A 49VAL A 50ILE A 51TYR A 14 | None | 1.03A | 1s9qA-4jqpA:undetectable | 1s9qA-4jqpA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 4 | LEU A 291VAL A 292ILE A 295TRP A 320 | None | 0.83A | 1s9qA-4n1yA:28.3 | 1s9qA-4n1yA:27.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9d | RIK1-ASSOCIATEDFACTOR 1 (Schizosaccharomycespombe) |
no annotation | 4 | ASP B 516LEU B 502VAL B 503ILE B 496 | None | 0.93A | 1s9qA-4o9dB:undetectable | 1s9qA-4o9dB:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pj6 | LEUCYL-CYSTINYLAMINOPEPTIDASE (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 4 | ASP A 454LEU A 457VAL A 458ILE A 461 | None | 0.83A | 1s9qA-4pj6A:undetectable | 1s9qA-4pj6A:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q7l | UNCHARACTERIZED ABCTRANSPORTERATP-BINDING PROTEINTM_0288 (Thermotogamaritima) |
PF00005(ABC_tran) | 4 | ASP A 418LEU A 413VAL A 414ILE A 355 | None | 0.99A | 1s9qA-4q7lA:undetectable | 1s9qA-4q7lA:24.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qjy | GH127BETA-L-ARABINOFURANOSIDASE (Geobacillusstearothermophilus) |
PF07944(Glyco_hydro_127) | 4 | ASP A 183LEU A 129TRP A 126TYR A 164 | None | 0.90A | 1s9qA-4qjyA:undetectable | 1s9qA-4qjyA:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ql6 | CARBOXY-TERMINALPROCESSING PROTEASE (Chlamydiatrachomatis) |
PF00595(PDZ)PF03572(Peptidase_S41) | 4 | ASP A 394LEU A 448VAL A 447ILE A 472 | None | 0.91A | 1s9qA-4ql6A:undetectable | 1s9qA-4ql6A:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r5q | CRISPR-ASSOCIATEDEXONUCLEASE, CAS4FAMILY (Pyrobaculumcalidifontis) |
PF01930(Cas_Cas4) | 4 | ASP A 123LEU A 124VAL A 125ILE A 126 | MG A 301 (-2.6A)NoneNoneNone | 1.03A | 1s9qA-4r5qA:undetectable | 1s9qA-4r5qA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9j | FICOLIN-2 (Homo sapiens) |
no annotation | 4 | LEU G 170VAL G 171TRP G 268TYR G 182 | None | 0.88A | 1s9qA-4r9jG:undetectable | 1s9qA-4r9jG:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wji | PUTATIVECYCLOHEXADIENYLDEHYDROGENASE ANDADH PREPHENATEDEHYDROGENASE (Sinorhizobiummeliloti) |
PF02153(PDH) | 4 | ASP A 97VAL A 95ILE A 94TRP A 166 | None | 0.97A | 1s9qA-4wjiA:undetectable | 1s9qA-4wjiA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwj | SENSORY TRANSDUCTIONHISTIDINE KINASE,PUTATIVE (Borreliellaburgdorferi) |
PF00497(SBP_bac_3) | 4 | ASP A 195LEU A 196VAL A 197ILE A 198 | None | 0.99A | 1s9qA-5bwjA:undetectable | 1s9qA-5bwjA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cjj | PHOSPHORIBOSYLGLYCINAMIDEFORMYLTRANSFERASE (Campylobacterjejuni) |
PF00551(Formyl_trans_N) | 4 | ASP A 73LEU A 76VAL A 77ILE A 80 | NoneNoneNoneGOL A 201 (-4.6A) | 0.37A | 1s9qA-5cjjA:undetectable | 1s9qA-5cjjA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fq6 | PUTATIVE LIPOPROTEIN (Bacteroidesthetaiotaomicron) |
PF12771(SusD-like_2) | 4 | LEU A 254VAL A 255ILE A 266TYR A 39 | None | 0.98A | 1s9qA-5fq6A:undetectable | 1s9qA-5fq6A:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzs | GGDEF FAMILY PROTEIN (Vibrio cholerae) |
PF00497(SBP_bac_3) | 4 | ASP A 447LEU A 360VAL A 361ILE A 424 | None | 0.95A | 1s9qA-5gzsA:undetectable | 1s9qA-5gzsA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h42 | UNCHARACTERIZEDPROTEIN (Lachnoclostridiumphytofermentans) |
PF17167(Glyco_hydro_36) | 4 | LEU A 449VAL A 448ILE A 447TYR A 427 | None | 0.87A | 1s9qA-5h42A:undetectable | 1s9qA-5h42A:12.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hg0 | PANTOTHENATESYNTHETASE (Francisellatularensis) |
PF02569(Pantoate_ligase) | 4 | ASP A 150VAL A 154ILE A 157TYR A 70 | SAM A 301 (-4.2A)NoneNoneNone | 1.01A | 1s9qA-5hg0A:undetectable | 1s9qA-5hg0A:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jgy | ALDOSE REDUCTASE,AKR4C13 (Zea mays) |
PF00248(Aldo_ket_red) | 4 | ASP A 156LEU A 153VAL A 154ILE A 162 | None | 1.02A | 1s9qA-5jgyA:undetectable | 1s9qA-5jgyA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k9x | TRYPTOPHAN SYNTHASEALPHA CHAIN (Legionellapneumophila) |
PF00290(Trp_syntA) | 4 | LEU A 128VAL A 129ILE A 127TRP A 143 | None | 1.01A | 1s9qA-5k9xA:undetectable | 1s9qA-5k9xA:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kba | DESIGNED PROTEINANK1C2 (syntheticconstruct) |
PF12796(Ank_2) | 4 | ASP A 82LEU A 86VAL A 84ILE A 87 | None | 0.98A | 1s9qA-5kbaA:undetectable | 1s9qA-5kbaA:25.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kgn | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Caenorhabditiselegans) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 4 | LEU A 156VAL A 157ILE A 160TYR A 321 | None | 0.69A | 1s9qA-5kgnA:undetectable | 1s9qA-5kgnA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5med | ARACHIDONATE15-LIPOXYGENASE (Cyanothece sp.PCC 8801) |
PF00305(Lipoxygenase) | 4 | ASP A 58LEU A 61VAL A 62ILE A 65 | None | 0.58A | 1s9qA-5medA:undetectable | 1s9qA-5medA:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mzn | HELICASESEN1,HELICASE SEN1 (Saccharomycescerevisiae) |
PF13086(AAA_11)PF13087(AAA_12) | 4 | ASP A1305LEU A1306VAL A1307ILE A1310 | NoneGOL A2045 (-3.9A)EDO A2022 (-4.1A)None | 0.75A | 1s9qA-5mznA:undetectable | 1s9qA-5mznA:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n5z | RNA POLYMERASEI-SPECIFICTRANSCRIPTIONINITIATION FACTORRRN3 (Saccharomycescerevisiae) |
PF05327(RRN3) | 4 | ASP O 397LEU O 400VAL O 401ILE O 404 | None | 0.34A | 1s9qA-5n5zO:undetectable | 1s9qA-5n5zO:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o19 | GENOME POLYPROTEIN (Japaneseencephalitisvirus) |
no annotation | 4 | ASP A 276LEU A 275VAL A 274ILE A 273 | None | 1.01A | 1s9qA-5o19A:undetectable | 1s9qA-5o19A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t4m | PROTOCADHERIN-15 (Homo sapiens) |
PF00028(Cadherin) | 4 | ASP A 341LEU A 342VAL A 343ILE A 344 | None | 0.93A | 1s9qA-5t4mA:undetectable | 1s9qA-5t4mA:19.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 4 | ASP A 303LEU A 306ILE A 310TRP A 335 | None | 0.90A | 1s9qA-5toaA:27.9 | 1s9qA-5toaA:34.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 4 | LEU A 306VAL A 307ILE A 310TRP A 335 | None | 0.52A | 1s9qA-5toaA:27.9 | 1s9qA-5toaA:34.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uly | - (-) |
no annotation | 4 | ASP A 341LEU A 342VAL A 343ILE A 344 | None | 0.89A | 1s9qA-5ulyA:undetectable | 1s9qA-5ulyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6a2f | - (-) |
no annotation | 4 | ASP A 97LEU A 98VAL A 99ILE A 100 | None | 0.85A | 1s9qA-6a2fA:undetectable | 1s9qA-6a2fA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cv7 | - (-) |
no annotation | 4 | ASP A 341LEU A 342VAL A 343ILE A 344 | None | 0.93A | 1s9qA-6cv7A:undetectable | 1s9qA-6cv7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eic | MYCOBACTERIUMTUBERCULOSISMONOGLYCERIDE LIPASE (Mycobacteriumtuberculosis) |
no annotation | 4 | LEU C 107VAL C 106ILE C 105TYR C 251 | None | 0.92A | 1s9qA-6eicC:undetectable | 1s9qA-6eicC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eks | SIALIDASE (Vibrio cholerae) |
no annotation | 4 | ASP A 602LEU A 601VAL A 600ILE A 599 | GOL A 905 ( 4.8A)NoneNoneNone | 0.63A | 1s9qA-6eksA:undetectable | 1s9qA-6eksA:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eo2 | TRANSCRIPTIONALREGULATORY PROTEINRCSB (Salmonellaenterica) |
no annotation | 4 | ASP A 56LEU A 86VAL A 85ILE A 106 | None | 0.83A | 1s9qA-6eo2A:undetectable | 1s9qA-6eo2A:23.46 |