SIMILAR PATTERNS OF AMINO ACIDS FOR 1S9Q_A_CHDA459

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 LEU A 330
VAL A 331
ILE A 334
TYR A 478
 None
None
None
FAD  A 750 (-3.4A)
 0.69A 1s9qA-1amoA:
undetectable		 1s9qA-1amoA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ati GLYCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A 390
VAL A 389
ILE A 388
TYR A 296
 None
 1.03A 1s9qA-1atiA:
0.1		 1s9qA-1atiA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		4 ASP A 173
LEU A 193
VAL A 192
ILE A 212
 LLP  A 198 ( 3.0A)
None
None
None
 1.03A 1s9qA-1cs1A:
undetectable		 1s9qA-1cs1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6q HNRNP ARGININE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF06325
(PrmA) 		4 ASP 1  64
LEU 1  63
VAL 1  62
ILE 1  61
 None
 0.97A 1s9qA-1g6q1:
undetectable		 1s9qA-1g6q1:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASP A 351
LEU A 354
VAL A 355
ILE A 358
TRP A 383
 None
 0.72A 1s9qA-1pcgA:
27.0		 1s9qA-1pcgA:
35.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ASP A 335
LEU A 338
VAL A 339
ILE A 342
 None
 0.26A 1s9qA-1q8iA:
0.0		 1s9qA-1q8iA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr7 PHENYLALANINE-REGULA
TED
3-DEOXY-D-ARABINO-HE
PTULOSONATE-7-PHOSPH
ATE SYNTHASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		4 VAL A 262
ILE A 297
TRP A 159
TYR A  94
 None
None
None
PEP  A1352 (-4.3A)
 0.96A 1s9qA-1qr7A:
undetectable		 1s9qA-1qr7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qv9 F420-DEPENDENT
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE

(Methanopyrus
kandleri) 		PF01993
(MTD) 		4 ASP A  99
LEU A 118
VAL A 119
ILE A 117
 None
 1.03A 1s9qA-1qv9A:
0.0		 1s9qA-1qv9A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		4 ASP A 178
LEU A 179
VAL A 180
ILE A 160
 None
 0.99A 1s9qA-1susA:
undetectable		 1s9qA-1susA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		4 ASP A  65
LEU A  66
VAL A  67
ILE A 185
 MG  A1601 ( 2.7A)
None
None
None
 0.89A 1s9qA-1t8qA:
undetectable		 1s9qA-1t8qA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuj ODORANT BINDING
PROTEIN ASP2

(Apis mellifera) 		PF01395
(PBP_GOBP) 		4 ASP A  85
LEU A  88
VAL A  89
ILE A  92
 None
 0.74A 1s9qA-1tujA:
undetectable		 1s9qA-1tujA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA

(Escherichia
coli) 		PF01938
(TRAM)
PF05958
(tRNA_U5-meth_tr) 		4 ASP A 292
LEU A 361
VAL A 360
ILE A 384
 None
 0.90A 1s9qA-1uwvA:
undetectable		 1s9qA-1uwvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdv HYPOTHETICAL PROTEIN
APE2540

(Aeropyrum
pernix) 		PF04073
(tRNA_edit) 		4 ASP A  50
LEU A  49
VAL A  48
ILE A  47
 None
 0.90A 1s9qA-1wdvA:
undetectable		 1s9qA-1wdvA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ASP A 329
VAL A 333
ILE A 336
TRP A 361
 None
 0.93A 1s9qA-1xb7A:
28.7		 1s9qA-1xb7A:
60.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 ASP X 246
LEU X 249
VAL X 250
ILE X 253
 None
 0.46A 1s9qA-1z3iX:
undetectable		 1s9qA-1z3iX:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zit TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg) 		4 ASP A  52
LEU A  51
VAL A  50
ILE A  49
 None
 0.96A 1s9qA-1zitA:
undetectable		 1s9qA-1zitA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv9 CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 ASP A  12
LEU A  11
VAL A  10
ILE A   9
 None
 0.98A 1s9qA-1zv9A:
undetectable		 1s9qA-1zv9A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		4 ASP A  61
LEU A 161
VAL A 160
TYR A  25
 None
None
None
SAH  A4001 (-4.4A)
 1.02A 1s9qA-2a14A:
undetectable		 1s9qA-2a14A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))

(Streptococcus
pyogenes) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ASP A 113
LEU A 112
VAL A 111
ILE A 110
 None
 0.91A 1s9qA-2a9fA:
undetectable		 1s9qA-2a9fA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aky ADENYLATE KINASE

(Saccharomyces
cerevisiae) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 ASP A 122
LEU A 125
VAL A 126
ILE A 129
 None
 0.69A 1s9qA-2akyA:
undetectable		 1s9qA-2akyA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d39 FICOLIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		4 ASP A 207
LEU A 208
VAL A 209
TRP A 306
 None
 0.86A 1s9qA-2d39A:
undetectable		 1s9qA-2d39A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d39 FICOLIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		4 LEU A 208
VAL A 209
TRP A 306
TYR A 220
 None
 1.00A 1s9qA-2d39A:
undetectable		 1s9qA-2d39A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmh MYOFERLIN

(Homo sapiens) 		PF00168
(C2) 		4 ASP A 126
LEU A 127
VAL A 128
ILE A 129
 None
 0.91A 1s9qA-2dmhA:
undetectable		 1s9qA-2dmhA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASP A 273
LEU A 276
VAL A 277
ILE A 280
TRP A 305
TYR A 436
 OHT  A 500 (-3.1A)
OHT  A 500 (-4.9A)
None
None
None
None
 0.56A 1s9qA-2gpvA:
35.2		 1s9qA-2gpvA:
99.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvk HEME PEROXIDASE

(Bacteroides
thetaiotaomicron) 		PF04261
(Dyp_perox) 		4 ASP A 107
LEU A 108
VAL A  28
ILE A  27
 None
None
EDO  A 322 ( 4.5A)
None
 1.03A 1s9qA-2gvkA:
undetectable		 1s9qA-2gvkA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icu HYPOTHETICAL PROTEIN
YEDK

(Escherichia
coli) 		PF02586
(SRAP) 		4 ASP A 160
LEU A 163
VAL A 164
TRP A 110
 None
 0.76A 1s9qA-2icuA:
undetectable		 1s9qA-2icuA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ido DNA POLYMERASE III
EPSILON SUBUNIT

(Escherichia
coli) 		PF00929
(RNase_T) 		4 ASP A  12
LEU A  11
VAL A  10
ILE A   9
 MN  A1001 (-2.6A)
None
None
None
 0.99A 1s9qA-2idoA:
undetectable		 1s9qA-2idoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		4 ASP A  61
LEU A 161
VAL A 160
TYR A  25
 None
None
None
SAH  A4001 (-4.4A)
 0.91A 1s9qA-2iipA:
undetectable		 1s9qA-2iipA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk9 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 1

(Homo sapiens) 		PF00622
(SPRY) 		4 ASP A 143
LEU A 144
ILE A 172
TRP A 104
 None
 0.95A 1s9qA-2jk9A:
undetectable		 1s9qA-2jk9A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oap TYPE II SECRETION
SYSTEM PROTEIN

(Archaeoglobus
fulgidus) 		PF00437
(T2SSE) 		4 ASP 1 173
LEU 1 172
VAL 1 171
ILE 1 170
 None
 0.96A 1s9qA-2oap1:
undetectable		 1s9qA-2oap1:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ASP A 351
LEU A 354
ILE A 358
TRP A 383
 None
 0.86A 1s9qA-2ocfA:
27.2		 1s9qA-2ocfA:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 354
VAL A 355
ILE A 358
TRP A 383
 None
 0.41A 1s9qA-2ocfA:
27.2		 1s9qA-2ocfA:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ASP A 358
LEU A 359
VAL A 360
ILE A 361
 None
 0.84A 1s9qA-2pljA:
undetectable		 1s9qA-2pljA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7b ACETYLTRANSFERASE,
GNAT FAMILY

(Streptococcus
agalactiae) 		PF00583
(Acetyltransf_1) 		4 ASP A 118
LEU A 117
VAL A 116
ILE A 115
 FLC  A 164 (-3.2A)
None
None
None
 0.80A 1s9qA-2q7bA:
undetectable		 1s9qA-2q7bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe8 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF03022
(MRJP) 		4 ASP A 202
LEU A 201
VAL A 200
ILE A 199
 None
 0.89A 1s9qA-2qe8A:
undetectable		 1s9qA-2qe8A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		4 ASP A 398
LEU A 399
VAL A 400
ILE A 401
 None
 0.99A 1s9qA-2rchA:
undetectable		 1s9qA-2rchA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnp FICOLIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		4 LEU F 179
VAL F 180
TRP F 277
TYR F 191
 None
 0.89A 1s9qA-2wnpF:
undetectable		 1s9qA-2wnpF:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		4 ASP J 335
VAL J 333
ILE J 332
TYR J 462
 None
 0.94A 1s9qA-2wp8J:
undetectable		 1s9qA-2wp8J:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b83 TEN-D3

(Homo sapiens) 		PF00041
(fn3) 		4 ASP A  48
LEU A  32
VAL A  33
ILE A  71
 None
 0.97A 1s9qA-3b83A:
undetectable		 1s9qA-3b83A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cah AGGLUTININ II

(Sambucus nigra) 		PF00652
(Ricin_B_lectin) 		4 ASP A 114
LEU A  97
VAL A  98
ILE A  91
 NAG  A 258 ( 3.7A)
None
None
None
 0.98A 1s9qA-3cahA:
undetectable		 1s9qA-3cahA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 ASP A  92
LEU A  93
VAL A  94
ILE A  95
 None
 0.92A 1s9qA-3ciaA:
undetectable		 1s9qA-3ciaA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n ASPARTATE
CARBAMOYLTRANSFERASE

(Aquifex
aeolicus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU B 150
VAL B 149
ILE B 175
TYR B 230
 None
 0.75A 1s9qA-3d6nB:
undetectable		 1s9qA-3d6nB:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkz THIOESTERASE
SUPERFAMILY PROTEIN

(Bordetella
parapertussis) 		PF03061
(4HBT) 		4 ASP A 123
LEU A 124
VAL A 125
ILE A 126
 None
 0.88A 1s9qA-3dkzA:
undetectable		 1s9qA-3dkzA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g12 PUTATIVE
LACTOYLGLUTATHIONE
LYASE

(Bdellovibrio
bacteriovorus) 		no annotation 4 ASP A 107
LEU A 106
VAL A 105
ILE A 104
 None
 0.93A 1s9qA-3g12A:
undetectable		 1s9qA-3g12A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4c TRANSCRIPTION FACTOR
TFIIB-LIKE

(Trypanosoma
brucei) 		no annotation 4 ASP A 202
LEU A 205
VAL A 206
ILE A 209
 None
 0.55A 1s9qA-3h4cA:
undetectable		 1s9qA-3h4cA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASP A 364
LEU A 369
VAL A 370
ILE A 479
 None
 0.86A 1s9qA-3hn7A:
undetectable		 1s9qA-3hn7A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpd HYDROXYETHYLTHIAZOLE
KINASE

(Pyrococcus
horikoshii) 		PF02110
(HK) 		4 ASP A  92
LEU A  91
VAL A  90
ILE A  89
 None
 1.01A 1s9qA-3hpdA:
undetectable		 1s9qA-3hpdA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib7 ICC PROTEIN

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		4 ASP A 133
LEU A 132
VAL A 131
ILE A 130
 None
 1.02A 1s9qA-3ib7A:
undetectable		 1s9qA-3ib7A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in6 FMN-BINDING PROTEIN

(Syntrophomonas
wolfei) 		no annotation 4 ASP A 104
LEU A 132
VAL A 133
ILE A  60
 None
 0.81A 1s9qA-3in6A:
undetectable		 1s9qA-3in6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		4 ASP A 229
LEU A 228
VAL A 227
ILE A 226
 None
 1.02A 1s9qA-3j1cA:
undetectable		 1s9qA-3j1cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw0 CYSTEINE PEPTIDASE

(Bacillus cereus) 		PF05708
(Peptidase_C92) 		4 ASP A  68
VAL A 136
ILE A 139
TYR A  79
 LYS  A 201 (-2.8A)
None
None
None
 0.89A 1s9qA-3kw0A:
undetectable		 1s9qA-3kw0A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 ASP A  12
LEU A  11
VAL A  10
ILE A   9
 None
 0.95A 1s9qA-3l8qA:
undetectable		 1s9qA-3l8qA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF01053
(Cys_Met_Meta_PP) 		4 ASP A 347
LEU A 358
VAL A 359
ILE A 387
 None
 0.90A 1s9qA-3ndnA:
undetectable		 1s9qA-3ndnA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q80 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01128
(IspD) 		4 ASP A 193
LEU A 196
VAL A 197
ILE A 200
 None
 0.86A 1s9qA-3q80A:
undetectable		 1s9qA-3q80A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica) 		PF00291
(PALP) 		4 ASP A  16
LEU A  17
VAL A  18
ILE A 327
 None
 0.88A 1s9qA-3r0zA:
undetectable		 1s9qA-3r0zA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9p ACKA

(Mycobacterium
avium) 		PF00871
(Acetate_kinase) 		4 ASP A 343
LEU A 342
VAL A 341
ILE A 340
 None
 1.02A 1s9qA-3r9pA:
undetectable		 1s9qA-3r9pA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		4 ASP X  18
LEU X  19
VAL X  20
ILE X 329
 None
 1.01A 1s9qA-3ss7X:
undetectable		 1s9qA-3ss7X:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlx ADENYLATE KINASE 2

(Plasmodium
falciparum) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 ASP A 145
LEU A 148
VAL A 149
ILE A 152
 None
 0.52A 1s9qA-3tlxA:
undetectable		 1s9qA-3tlxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wry TM-1 PROTEIN

(Solanum
lycopersicum) 		PF06792
(UPF0261) 		4 ASP A 255
LEU A 256
VAL A 257
ILE A 262
 None
 1.02A 1s9qA-3wryA:
undetectable		 1s9qA-3wryA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica) 		PF00069
(Pkinase)
PF09632
(Rac1) 		4 ASP B 212
LEU B 157
VAL B 158
ILE B 147
 None
 0.93A 1s9qA-4ci6B:
undetectable		 1s9qA-4ci6B:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ASP A  52
LEU A  55
VAL A  56
ILE A  59
 None
 0.69A 1s9qA-4cvqA:
undetectable		 1s9qA-4cvqA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eku PROTEIN-TYROSINE
KINASE 2-BETA

(Homo sapiens) 		PF00373
(FERM_M) 		4 ASP A 278
LEU A 279
VAL A 280
ILE A 281
 None
 0.83A 1s9qA-4ekuA:
undetectable		 1s9qA-4ekuA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 4 ASP D 337
VAL D 403
ILE D 472
TYR D 171
 None
 0.99A 1s9qA-4em6D:
undetectable		 1s9qA-4em6D:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6q PROLINE
DEHYDROGENASE

(Deinococcus
radiodurans) 		PF01619
(Pro_dh) 		4 ASP A  60
VAL A  95
ILE A 132
TYR A 193
 None
None
None
FAD  A2001 (-4.1A)
 0.75A 1s9qA-4h6qA:
undetectable		 1s9qA-4h6qA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hd1 SQUALENE SYNTHASE
HPNC

(Alicyclobacillus
acidocaldarius) 		PF00494
(SQS_PSY) 		4 LEU A 139
VAL A 140
ILE A 143
TYR A  69
 None
 0.48A 1s9qA-4hd1A:
undetectable		 1s9qA-4hd1A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpm BCL-6
COREPRESSOR-LIKE
PROTEIN 1

(Homo sapiens) 		PF16553
(PUFD) 		4 LEU A1689
VAL A1690
ILE A1648
TYR A1657
 None
 1.02A 1s9qA-4hpmA:
undetectable		 1s9qA-4hpmA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Paraburkholderia
phymatum) 		PF04166
(PdxA) 		4 ASP A  87
LEU A  49
VAL A  50
ILE A  20
 None
 0.99A 1s9qA-4jqpA:
undetectable		 1s9qA-4jqpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Paraburkholderia
phymatum) 		PF04166
(PdxA) 		4 LEU A  49
VAL A  50
ILE A  51
TYR A  14
 None
 1.03A 1s9qA-4jqpA:
undetectable		 1s9qA-4jqpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		4 LEU A 291
VAL A 292
ILE A 295
TRP A 320
 None
 0.83A 1s9qA-4n1yA:
28.3		 1s9qA-4n1yA:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9d RIK1-ASSOCIATED
FACTOR 1

(Schizosaccharomyces
pombe) 		no annotation 4 ASP B 516
LEU B 502
VAL B 503
ILE B 496
 None
 0.93A 1s9qA-4o9dB:
undetectable		 1s9qA-4o9dB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASP A 454
LEU A 457
VAL A 458
ILE A 461
 None
 0.83A 1s9qA-4pj6A:
undetectable		 1s9qA-4pj6A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7l UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 ASP A 418
LEU A 413
VAL A 414
ILE A 355
 None
 0.99A 1s9qA-4q7lA:
undetectable		 1s9qA-4q7lA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		4 ASP A 183
LEU A 129
TRP A 126
TYR A 164
 None
 0.90A 1s9qA-4qjyA:
undetectable		 1s9qA-4qjyA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE

(Chlamydia
trachomatis) 		PF00595
(PDZ)
PF03572
(Peptidase_S41) 		4 ASP A 394
LEU A 448
VAL A 447
ILE A 472
 None
 0.91A 1s9qA-4ql6A:
undetectable		 1s9qA-4ql6A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5q CRISPR-ASSOCIATED
EXONUCLEASE, CAS4
FAMILY

(Pyrobaculum
calidifontis) 		PF01930
(Cas_Cas4) 		4 ASP A 123
LEU A 124
VAL A 125
ILE A 126
 MG  A 301 (-2.6A)
None
None
None
 1.03A 1s9qA-4r5qA:
undetectable		 1s9qA-4r5qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9j FICOLIN-2

(Homo sapiens) 		no annotation 4 LEU G 170
VAL G 171
TRP G 268
TYR G 182
 None
 0.88A 1s9qA-4r9jG:
undetectable		 1s9qA-4r9jG:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wji PUTATIVE
CYCLOHEXADIENYL
DEHYDROGENASE AND
ADH PREPHENATE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02153
(PDH) 		4 ASP A  97
VAL A  95
ILE A  94
TRP A 166
 None
 0.97A 1s9qA-4wjiA:
undetectable		 1s9qA-4wjiA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwj SENSORY TRANSDUCTION
HISTIDINE KINASE,
PUTATIVE

(Borreliella
burgdorferi) 		PF00497
(SBP_bac_3) 		4 ASP A 195
LEU A 196
VAL A 197
ILE A 198
 None
 0.99A 1s9qA-5bwjA:
undetectable		 1s9qA-5bwjA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjj PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Campylobacter
jejuni) 		PF00551
(Formyl_trans_N) 		4 ASP A  73
LEU A  76
VAL A  77
ILE A  80
 None
None
None
GOL  A 201 (-4.6A)
 0.37A 1s9qA-5cjjA:
undetectable		 1s9qA-5cjjA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 LEU A 254
VAL A 255
ILE A 266
TYR A  39
 None
 0.98A 1s9qA-5fq6A:
undetectable		 1s9qA-5fq6A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzs GGDEF FAMILY PROTEIN

(Vibrio cholerae) 		PF00497
(SBP_bac_3) 		4 ASP A 447
LEU A 360
VAL A 361
ILE A 424
 None
 0.95A 1s9qA-5gzsA:
undetectable		 1s9qA-5gzsA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 LEU A 449
VAL A 448
ILE A 447
TYR A 427
 None
 0.87A 1s9qA-5h42A:
undetectable		 1s9qA-5h42A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hg0 PANTOTHENATE
SYNTHETASE

(Francisella
tularensis) 		PF02569
(Pantoate_ligase) 		4 ASP A 150
VAL A 154
ILE A 157
TYR A  70
 SAM  A 301 (-4.2A)
None
None
None
 1.01A 1s9qA-5hg0A:
undetectable		 1s9qA-5hg0A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgy ALDOSE REDUCTASE,
AKR4C13

(Zea mays) 		PF00248
(Aldo_ket_red) 		4 ASP A 156
LEU A 153
VAL A 154
ILE A 162
 None
 1.02A 1s9qA-5jgyA:
undetectable		 1s9qA-5jgyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Legionella
pneumophila) 		PF00290
(Trp_syntA) 		4 LEU A 128
VAL A 129
ILE A 127
TRP A 143
 None
 1.01A 1s9qA-5k9xA:
undetectable		 1s9qA-5k9xA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kba DESIGNED PROTEIN
ANK1C2

(synthetic
construct) 		PF12796
(Ank_2) 		4 ASP A  82
LEU A  86
VAL A  84
ILE A  87
 None
 0.98A 1s9qA-5kbaA:
undetectable		 1s9qA-5kbaA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 LEU A 156
VAL A 157
ILE A 160
TYR A 321
 None
 0.69A 1s9qA-5kgnA:
undetectable		 1s9qA-5kgnA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5med ARACHIDONATE
15-LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		4 ASP A  58
LEU A  61
VAL A  62
ILE A  65
 None
 0.58A 1s9qA-5medA:
undetectable		 1s9qA-5medA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		4 ASP A1305
LEU A1306
VAL A1307
ILE A1310
 None
GOL  A2045 (-3.9A)
EDO  A2022 (-4.1A)
None
 0.75A 1s9qA-5mznA:
undetectable		 1s9qA-5mznA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3

(Saccharomyces
cerevisiae) 		PF05327
(RRN3) 		4 ASP O 397
LEU O 400
VAL O 401
ILE O 404
 None
 0.34A 1s9qA-5n5zO:
undetectable		 1s9qA-5n5zO:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o19 GENOME POLYPROTEIN

(Japanese
encephalitis
virus) 		no annotation 4 ASP A 276
LEU A 275
VAL A 274
ILE A 273
 None
 1.01A 1s9qA-5o19A:
undetectable		 1s9qA-5o19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4m PROTOCADHERIN-15

(Homo sapiens) 		PF00028
(Cadherin) 		4 ASP A 341
LEU A 342
VAL A 343
ILE A 344
 None
 0.93A 1s9qA-5t4mA:
undetectable		 1s9qA-5t4mA:
19.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ASP A 303
LEU A 306
ILE A 310
TRP A 335
 None
 0.90A 1s9qA-5toaA:
27.9		 1s9qA-5toaA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 306
VAL A 307
ILE A 310
TRP A 335
 None
 0.52A 1s9qA-5toaA:
27.9		 1s9qA-5toaA:
34.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uly -

(-) 		no annotation 4 ASP A 341
LEU A 342
VAL A 343
ILE A 344
 None
 0.89A 1s9qA-5ulyA:
undetectable		 1s9qA-5ulyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a2f -

(-) 		no annotation 4 ASP A  97
LEU A  98
VAL A  99
ILE A 100
 None
 0.85A 1s9qA-6a2fA:
undetectable		 1s9qA-6a2fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv7 -

(-) 		no annotation 4 ASP A 341
LEU A 342
VAL A 343
ILE A 344
 None
 0.93A 1s9qA-6cv7A:
undetectable		 1s9qA-6cv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE

(Mycobacterium
tuberculosis) 		no annotation 4 LEU C 107
VAL C 106
ILE C 105
TYR C 251
 None
 0.92A 1s9qA-6eicC:
undetectable		 1s9qA-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 ASP A 602
LEU A 601
VAL A 600
ILE A 599
 GOL  A 905 ( 4.8A)
None
None
None
 0.63A 1s9qA-6eksA:
undetectable		 1s9qA-6eksA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo2 TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB

(Salmonella
enterica) 		no annotation 4 ASP A  56
LEU A  86
VAL A  85
ILE A 106
 None
 0.83A 1s9qA-6eo2A:
undetectable		 1s9qA-6eo2A:
23.46