SIMILAR PATTERNS OF AMINO ACIDS FOR 1S9P_D_DESD600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE


(Streptomyces
antibioticus)
PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase)
5 LEU A 268
LEU A 271
ALA A 274
VAL A 298
LEU A 328
None
1.07A 1s9pD-1e3hA:
undetectable
1s9pD-1e3hA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE


(Thermotoga
maritima)
PF00128
(Alpha-amylase)
PF09083
(DUF1923)
5 LEU A 175
LEU A 174
TYR A  20
LEU A 124
ILE A   6
None
1.10A 1s9pD-1gjuA:
undetectable
1s9pD-1gjuA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpm GMP SYNTHETASE

(Escherichia
coli)
PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase)
5 LEU A 379
LEU A 376
LEU A 247
LEU A 391
ILE A 213
None
1.15A 1s9pD-1gpmA:
undetectable
1s9pD-1gpmA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA


(Bacillus
thuringiensis)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid)
5 LEU A 173
LEU A 176
ALA A 180
LEU A 120
ILE A 166
None
1.02A 1s9pD-1i5pA:
2.2
1s9pD-1i5pA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im3 CYTOMEGALOVIRUS
PROTEIN US2


(Human
betaherpesvirus
5)
PF05963
(Cytomega_US3)
5 LEU D 131
LEU D 120
VAL D  89
LEU D 102
ILE D 129
None
1.15A 1s9pD-1im3D:
undetectable
1s9pD-1im3D:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iz1 LYSR-TYPE REGULATORY
PROTEIN


(Cupriavidus
necator)
PF00126
(HTH_1)
PF03466
(LysR_substrate)
5 LEU A   6
ALA A  13
LEU A  57
LEU A  43
ILE A  71
None
1.13A 1s9pD-1iz1A:
undetectable
1s9pD-1iz1A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k38 BETA-LACTAMASE OXA-2

(Salmonella
enterica)
PF00905
(Transpeptidase)
5 LEU A  75
ALA A  82
VAL A 119
TYR A 120
LEU A 191
None
None
None
KCX  A  70 ( 3.7A)
None
1.04A 1s9pD-1k38A:
0.0
1s9pD-1k38A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks9 2-DEHYDROPANTOATE
2-REDUCTASE


(Escherichia
coli)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 LEU A  68
MET A   1
VAL A 159
LEU A 152
ILE A  93
None
1.08A 1s9pD-1ks9A:
undetectable
1s9pD-1ks9A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1


(Streptomyces
coelicolor)
PF00067
(p450)
5 LEU A  24
LEU A   8
ALA A   7
LEU A 393
HIS A 291
None
1.11A 1s9pD-1odoA:
2.4
1s9pD-1odoA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 346
ALA A 350
GLU A 353
LEU A 387
ARG A 394
HIS A 524
EST  A   1 (-4.4A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
EST  A   1 (-3.7A)
EST  A   1 (-3.8A)
0.39A 1s9pD-1pcgA:
29.4
1s9pD-1pcgA:
36.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5j DNA POLYMERASE I

(Sulfolobus
solfataricus)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
5 LEU A 387
LEU A 386
LEU A 431
VAL A 365
LEU A 356
None
1.10A 1s9pD-1s5jA:
0.1
1s9pD-1s5jA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE


(Medicago sativa)
PF01596
(Methyltransf_3)
5 LEU A 179
LEU A 176
LEU A 170
LEU A 141
ILE A 148
None
1.13A 1s9pD-1susA:
undetectable
1s9pD-1susA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT


(Salmonella
enterica)
PF01791
(DeoC)
5 ALA A 244
GLU A 243
LEU A 208
LEU A 198
ILE A 177
None
1.09A 1s9pD-1to3A:
undetectable
1s9pD-1to3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udd TRANSCRIPTIONAL
REGULATOR


(Pyrococcus
horikoshii)
PF03070
(TENA_THI-4)
5 LEU A 130
LEU A 133
GLU A 204
LEU A  75
ILE A 181
None
0.88A 1s9pD-1uddA:
2.2
1s9pD-1uddA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmi PUTATIVE PHOSPHATE
ACETYLTRANSFERASE


(Escherichia
coli)
PF01515
(PTA_PTB)
5 ALA A  31
MET A  62
LEU A  65
VAL A  67
HIS A  58
None
1.12A 1s9pD-1vmiA:
undetectable
1s9pD-1vmiA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE


(Komagataeibacter
xylinus)
PF01270
(Glyco_hydro_8)
5 LEU A 328
LEU A 331
ALA A 335
GLU A 338
ILE A 247
None
1.04A 1s9pD-1wzzA:
undetectable
1s9pD-1wzzA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1


(Homo sapiens)
PF00104
(Hormone_recep)
8 LEU A 324
GLU A 331
MET A 362
LEU A 365
VAL A 369
ARG A 372
LEU A 401
HIS A 494
None
0.46A 1s9pD-1xb7A:
30.3
1s9pD-1xb7A:
58.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN


(Homo sapiens)
PF00102
(Y_phosphatase)
5 LEU A1157
LEU A1160
ALA A1164
LEU A 897
VAL A 895
None
0.80A 1s9pD-1yguA:
undetectable
1s9pD-1yguA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1


(Saccharomyces
cerevisiae)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
5 LEU A 470
ALA A 474
MET A 603
LEU A 507
VAL A 509
None
1.08A 1s9pD-2cvtA:
undetectable
1s9pD-2cvtA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fek LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE WZB


(Escherichia
coli)
PF01451
(LMWPc)
5 LEU A 131
ALA A 135
LEU A  23
VAL A   7
LEU A  60
None
0.99A 1s9pD-2fekA:
undetectable
1s9pD-2fekA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis)
PF01264
(Chorismate_synt)
5 LEU A 159
LEU A 155
ALA A 153
LEU A 367
ILE A 382
None
0.99A 1s9pD-2g85A:
undetectable
1s9pD-2g85A:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
11 LEU A 265
LEU A 268
ALA A 272
GLU A 275
MET A 306
LEU A 309
VAL A 313
ARG A 316
TYR A 326
LEU A 345
HIS A 434
None
OHT  A 500 (-4.1A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
None
OHT  A 500 (-3.8A)
OHT  A 500 (-4.5A)
OHT  A 500 (-4.3A)
OHT  A 500 ( 4.7A)
0.48A 1s9pD-2gpvA:
33.7
1s9pD-2gpvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
11 LEU A 265
LEU A 268
ALA A 272
MET A 306
LEU A 309
VAL A 313
ARG A 316
TYR A 326
LEU A 345
HIS A 434
ILE A 438
None
OHT  A 500 (-4.1A)
OHT  A 500 (-3.5A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
None
OHT  A 500 (-3.8A)
OHT  A 500 (-4.5A)
OHT  A 500 (-4.3A)
OHT  A 500 ( 4.7A)
None
0.60A 1s9pD-2gpvA:
33.7
1s9pD-2gpvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3j HYPOTHETICAL PROTEIN
PA4359


(Pseudomonas
aeruginosa)
PF04023
(FeoA)
5 LEU A  27
LEU A  32
ALA A  36
VAL A  52
LEU A  66
None
1.08A 1s9pD-2h3jA:
undetectable
1s9pD-2h3jA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum)
PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind)
5 LEU A 222
LEU A 225
VAL A 157
LEU A 175
ILE A 168
None
1.08A 1s9pD-2i0kA:
undetectable
1s9pD-2i0kA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT


(Pseudomonas
stutzeri)
PF02332
(Phenol_Hydrox)
6 LEU B 113
LEU B 121
GLU B 189
TYR B 125
LEU B 249
HIS B 109
None
1.41A 1s9pD-2incB:
undetectable
1s9pD-2incB:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k9x UNCHARACTERIZED
PROTEIN


(Trypanosoma
brucei)
PF09138
(Urm1)
5 LEU A  87
ALA A  77
GLU A  78
LEU A  44
ILE A   7
None
1.12A 1s9pD-2k9xA:
undetectable
1s9pD-2k9xA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD


(Escherichia
coli)
PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C)
5 LEU A  72
ALA A 131
GLU A 132
ARG A 143
LEU A 112
None
1.14A 1s9pD-2o7pA:
undetectable
1s9pD-2o7pA:
20.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 346
ALA A 350
GLU A 353
LEU A 387
ARG A 394
HIS A 524
EST  A 596 (-4.4A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
EST  A 596 (-4.2A)
0.58A 1s9pD-2ocfA:
30.1
1s9pD-2ocfA:
31.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR


(unidentified)
PF00104
(Hormone_recep)
5 LEU A  29
LEU A  32
ALA A  36
MET A  70
ARG A  80
1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
0.39A 1s9pD-2q3yA:
28.0
1s9pD-2q3yA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1v NITRILASE HOMOLOG 2

(Mus musculus)
PF00795
(CN_hydrolase)
5 ALA A 242
LEU A 210
VAL A 239
HIS A 148
ILE A 190
None
1.14A 1s9pD-2w1vA:
undetectable
1s9pD-2w1vA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE


(Nonomuraea
gerenzanensis)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 LEU A 179
ALA A 416
LEU A 502
VAL A 505
ILE A 160
None
0.85A 1s9pD-2wdwA:
undetectable
1s9pD-2wdwA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 LEU A 150
ALA A 390
LEU A 476
VAL A 479
ILE A 131
None
0.85A 1s9pD-2y3sA:
undetectable
1s9pD-2y3sA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE


(Thermus
thermophilus)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
5 LEU A  80
ALA A   7
LEU A  18
VAL A  16
ILE A  28
None
1.12A 1s9pD-2yzmA:
undetectable
1s9pD-2yzmA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128)
no annotation 5 LEU A 641
ALA A 587
VAL A 606
LEU A 621
ILE A 650
None
1.13A 1s9pD-3a0fA:
undetectable
1s9pD-3a0fA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbl REGULATORY PROTEIN
OF LACI FAMILY


(Chloroflexus
aggregans)
PF13377
(Peripla_BP_3)
5 LEU A 179
GLU A 218
ARG A 246
LEU A 277
ILE A 280
None
1.00A 1s9pD-3bblA:
undetectable
1s9pD-3bblA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpv TRANSCRIPTIONAL
REGULATOR


(Methanothermobacter
thermautotrophicus)
PF01047
(MarR)
5 LEU A  71
LEU A 103
VAL A 107
LEU A  40
ILE A  77
None
1.00A 1s9pD-3bpvA:
undetectable
1s9pD-3bpvA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c87 ENTEROCHELIN
ESTERASE


(Shigella
flexneri)
PF00756
(Esterase)
PF11806
(DUF3327)
5 LEU A 218
LEU A 224
ALA A 227
VAL A 276
LEU A 384
None
1.10A 1s9pD-3c87A:
undetectable
1s9pD-3c87A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 LEU A  99
ALA A  98
GLU A  96
LEU A 107
ILE A 102
None
None
ALF  A 501 ( 3.2A)
None
None
0.95A 1s9pD-3cmtA:
undetectable
1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 LEU A1099
ALA A1098
GLU A1096
LEU A1107
ILE A1102
None
None
ALF  A1501 ( 3.1A)
None
None
0.95A 1s9pD-3cmtA:
undetectable
1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 LEU A2099
ALA A2098
GLU A2096
LEU A2107
ILE A2102
None
None
ALF  A2501 ( 3.3A)
None
None
0.95A 1s9pD-3cmtA:
undetectable
1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 LEU A3099
ALA A3098
GLU A3096
LEU A3107
ILE A3102
None
None
ALF  A3501 ( 3.2A)
None
None
0.95A 1s9pD-3cmtA:
undetectable
1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 LEU A4099
ALA A4098
GLU A4096
LEU A4107
ILE A4102
None
None
ALF  A4501 ( 3.3A)
None
None
0.94A 1s9pD-3cmtA:
undetectable
1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 LEU A  99
ALA A  98
GLU A  96
LEU A 107
ILE A 102
None
None
ALF  A 501 ( 2.4A)
None
None
1.01A 1s9pD-3cmuA:
undetectable
1s9pD-3cmuA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 LEU A2099
ALA A2098
GLU A2096
LEU A2107
ILE A2102
None
None
ALF  A2501 ( 2.5A)
None
None
1.01A 1s9pD-3cmuA:
undetectable
1s9pD-3cmuA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 LEU A3099
ALA A3098
GLU A3096
LEU A3107
ILE A3102
None
None
ALF  A3501 ( 2.7A)
None
None
1.01A 1s9pD-3cmuA:
undetectable
1s9pD-3cmuA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE


(Bartonella
henselae)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
5 LEU A 149
LEU A  65
ALA A 123
LEU A 109
ILE A 147
None
0.97A 1s9pD-3girA:
undetectable
1s9pD-3girA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht4 ALUMINUM RESISTANCE
PROTEIN


(Bacillus cereus)
PF06838
(Met_gamma_lyase)
5 LEU A 307
LEU A 304
ALA A 301
VAL A 394
ILE A  14
None
1.05A 1s9pD-3ht4A:
undetectable
1s9pD-3ht4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128


(Homo sapiens)
PF02225
(PA)
5 LEU A  84
LEU A 117
ALA A 143
LEU A  47
ILE A 179
None
1.09A 1s9pD-3icuA:
undetectable
1s9pD-3icuA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4u BINDING COMPONENT OF
ABC TRANSPORTER


(Wolinella
succinogenes)
PF00497
(SBP_bac_3)
5 LEU A 204
ALA A  33
LEU A  44
LEU A   1
ILE A 193
None
0.89A 1s9pD-3k4uA:
undetectable
1s9pD-3k4uA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT


(Saccharomyces
cerevisiae)
PF00400
(WD40)
PF04053
(Coatomer_WDAD)
5 LEU A 726
LEU A 729
ALA A 733
LEU A 715
ILE A 748
None
1.04A 1s9pD-3mkqA:
undetectable
1s9pD-3mkqA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncc PROLACTIN

(Homo sapiens)
PF00103
(Hormone_1)
5 LEU A  15
LEU A  18
ALA A  22
LEU A 126
ILE A 193
None
1.12A 1s9pD-3nccA:
undetectable
1s9pD-3nccA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR


(Pseudomonas
putida)
PF00532
(Peripla_BP_1)
5 ALA A 120
LEU A 142
TYR A 313
LEU A 151
ILE A 147
None
1.11A 1s9pD-3o75A:
undetectable
1s9pD-3o75A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rht (GATASE1)-LIKE
PROTEIN


(Planctopirus
limnophila)
PF07090
(GATase1_like)
5 LEU A 190
LEU A 191
VAL A 251
LEU A  82
ILE A 148
None
1.12A 1s9pD-3rhtA:
undetectable
1s9pD-3rhtA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1


(synthetic
construct)
PF00104
(Hormone_recep)
5 LEU A  29
LEU A  32
MET A  70
ARG A  80
LEU A 111
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
0.81A 1s9pD-3ry9A:
28.5
1s9pD-3ry9A:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli)
PF02395
(Peptidase_S6)
5 LEU A 762
LEU A 794
ALA A 812
VAL A 850
ILE A 738
None
1.14A 1s9pD-3szeA:
undetectable
1s9pD-3szeA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufg GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT


(Campylobacter
jejuni)
PF02091
(tRNA-synt_2e)
5 LEU A  43
LEU A  40
ALA A  37
TYR A 237
LEU A 120
None
1.10A 1s9pD-3ufgA:
undetectable
1s9pD-3ufgA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes)
PF00232
(Glyco_hydro_1)
5 LEU A  71
LEU A  68
TYR A  76
LEU A 402
ILE A 429
None
0.81A 1s9pD-3wh7A:
undetectable
1s9pD-3wh7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiw GLYCOSYL HYDROLASE
FAMILY 88


(Pedobacter
heparinus)
PF07470
(Glyco_hydro_88)
5 LEU A 138
LEU A 141
ALA A 145
LEU A 182
TYR A 122
None
0.88A 1s9pD-3wiwA:
undetectable
1s9pD-3wiwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkh CELLOBIOSE
2-EPIMERASE


(Rhodothermus
marinus)
PF07221
(GlcNAc_2-epim)
5 LEU A 240
LEU A 268
ARG A 401
LEU A 202
ILE A 232
None
1.12A 1s9pD-3wkhA:
undetectable
1s9pD-3wkhA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avc LYSINE
ACETYLTRANSFERASE


(Mycobacterium
tuberculosis)
PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3)
5 ALA A 135
LEU A 139
VAL A 328
TYR A 204
LEU A 162
PEG  A1335 (-3.9A)
None
None
None
None
1.11A 1s9pD-4avcA:
undetectable
1s9pD-4avcA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
5 LEU A  68
LEU A  67
VAL A 344
HIS A  84
ILE A  83
None
1.13A 1s9pD-4c41A:
undetectable
1s9pD-4c41A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE


(Thermotoga
maritima)
PF13597
(NRDD)
5 LEU A 130
VAL A 134
LEU A 152
HIS A 208
ILE A 211
None
1.09A 1s9pD-4conA:
undetectable
1s9pD-4conA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima)
PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
5 LEU A 455
LEU A 393
ALA A 398
LEU A 403
VAL A 406
None
1.15A 1s9pD-4ddwA:
undetectable
1s9pD-4ddwA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gul PIRIN

(Homo sapiens)
PF02678
(Pirin)
PF05726
(Pirin_C)
5 LEU A 116
LEU A 246
VAL A 250
LEU A  36
ILE A 241
None
1.09A 1s9pD-4gulA:
undetectable
1s9pD-4gulA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA


(Thermotoga
maritima)
no annotation 5 LEU D1051
LEU D1052
ALA D1054
VAL D1017
TYR D1012
None
None
None
ADP  D1301 (-4.6A)
ADP  D1301 (-3.6A)
1.14A 1s9pD-4hluD:
undetectable
1s9pD-4hluD:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 446
LEU A 449
ALA A 452
VAL A 498
ILE A 417
None
None
None
GOL  A 606 ( 4.1A)
None
1.10A 1s9pD-4jgvA:
22.1
1s9pD-4jgvA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
7 LEU A 280
LEU A 283
ALA A 287
GLU A 290
MET A 321
LEU A 324
ARG A 331
None
0.46A 1s9pD-4n1yA:
30.0
1s9pD-4n1yA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE


(Geobacter
sulfurreducens)
PF00171
(Aldedh)
PF01619
(Pro_dh)
5 LEU A 275
LEU A 304
ALA A 356
VAL A 366
ILE A 273
None
None
P5F  A1101 ( 3.7A)
None
None
1.01A 1s9pD-4nmeA:
undetectable
1s9pD-4nmeA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt RETINOID X RECEPTOR

(Pediculus
humanus)
PF00104
(Hormone_recep)
5 LEU U 355
LEU U 358
LEU U 242
LEU U 300
ILE U 306
None
1.09A 1s9pD-4oztU:
19.4
1s9pD-4oztU:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4poo PUTATIVE RNA
METHYLASE


(Bacillus
subtilis)
PF06962
(rRNA_methylase)
5 LEU A  13
LEU A 135
ALA A  98
LEU A 126
ILE A 183
None
1.09A 1s9pD-4pooA:
undetectable
1s9pD-4pooA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18


(Serratia
proteamaculans)
PF00704
(Glyco_hydro_18)
5 LEU A 219
LEU A 271
TYR A 383
LEU A 260
ILE A 217
None
1.13A 1s9pD-4q22A:
undetectable
1s9pD-4q22A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uav HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN AT3G48420


(Arabidopsis
thaliana)
PF13419
(HAD_2)
5 LEU A 212
LEU A 213
ALA A 218
VAL A 194
ILE A 169
None
1.12A 1s9pD-4uavA:
undetectable
1s9pD-4uavA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 766
LEU A 769
ALA A 773
MET A 807
LEU A 810
ARG A 817
CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.5A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.7A)
0.58A 1s9pD-4udbA:
27.5
1s9pD-4udbA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uip REPEBODY (RAC1)

(Eptatretus
burgeri;
Listeria
monocytogenes;
synthetic
construct)
PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8)
5 LEU B 115
LEU B  91
ALA B  70
VAL B  57
LEU B  98
None
1.14A 1s9pD-4uipB:
undetectable
1s9pD-4uipB:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B


(Pseudomonas
aeruginosa)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
5 LEU B  61
ALA B  65
LEU B 176
LEU B  15
ILE B  99
None
1.06A 1s9pD-4wj3B:
undetectable
1s9pD-4wj3B:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE


(Mycolicibacterium
smegmatis)
PF00933
(Glyco_hydro_3)
6 ALA A 208
LEU A 261
VAL A 267
ARG A 216
HIS A 226
ILE A 192
None
None
None
None
ACT  A 401 (-3.5A)
None
1.19A 1s9pD-4yyfA:
undetectable
1s9pD-4yyfA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apg TSR3

(Vulcanisaeta
distributa)
PF04034
(Ribo_biogen_C)
5 ALA A 118
LEU A  93
TYR A 153
LEU A 164
ILE A 145
None
EEM  A1185 (-3.9A)
None
None
None
1.10A 1s9pD-5apgA:
undetectable
1s9pD-5apgA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dud YBGK

(Escherichia
coli)
PF02626
(CT_A_B)
5 LEU A 150
MET A  94
VAL A  44
LEU A 113
ILE A   4
None
1.11A 1s9pD-5dudA:
undetectable
1s9pD-5dudA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4v NUCLEOPROTEIN,PHOSPH
OPROTEIN


(Measles
morbillivirus)
PF00973
(Paramyxo_ncap)
PF13825
(Paramyxo_PNT)
5 LEU A  33
LEU A  36
LEU A  50
LEU A  58
ILE A 151
None
1.07A 1s9pD-5e4vA:
undetectable
1s9pD-5e4vA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE


(Bacillus
megaterium)
PF00067
(p450)
5 LEU A 418
ALA A 294
GLU A 293
LEU A 311
LEU A 273
None
0.98A 1s9pD-5e78A:
2.7
1s9pD-5e78A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE


(Pseudomonas
putida)
PF01494
(FAD_binding_3)
5 LEU X 329
ALA X 336
LEU X  24
VAL X  10
ILE X  58
None
0.99A 1s9pD-5evyX:
undetectable
1s9pD-5evyX:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE


(Micromonospora
griseorubida)
PF00067
(p450)
5 LEU A 147
LEU A 198
ALA A 202
GLU A 205
LEU A 338
None
None
None
None
HEM  A 413 ( 4.1A)
1.15A 1s9pD-5foiA:
undetectable
1s9pD-5foiA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN


(Candida
albicans)
PF09797
(NatB_MDM20)
6 LEU A 210
LEU A 213
ALA A 217
GLU A 220
LEU A 188
ILE A 183
None
1.39A 1s9pD-5k04A:
undetectable
1s9pD-5k04A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kum ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 12


(Gallus gallus)
PF01007
(IRK)
5 LEU A 280
GLU A 320
ARG A  44
HIS A 272
ILE A 274
None
1.13A 1s9pD-5kumA:
undetectable
1s9pD-5kumA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
5 ALA A1427
LEU A1415
TYR A1429
LEU A1542
ILE A1556
None
1.14A 1s9pD-5m59A:
undetectable
1s9pD-5m59A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
no annotation 5 LEU A 766
LEU A 769
ALA A 773
MET A 807
ARG A 817
ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.8A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
0.50A 1s9pD-5mwpA:
28.7
1s9pD-5mwpA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nm8 PIPY

(Synechococcus
elongatus)
PF01168
(Ala_racemase_N)
5 LEU A 115
LEU A 113
VAL A  82
ARG A 109
LEU A  96
None
1.13A 1s9pD-5nm8A:
undetectable
1s9pD-5nm8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF00583
(Acetyltransf_1)
5 LEU B 131
ALA B 127
VAL B 121
TYR B 132
ILE B  96
None
None
None
None
GOL  B 201 (-4.8A)
1.13A 1s9pD-5nnpB:
undetectable
1s9pD-5nnpB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE


(Papaver
somniferum)
no annotation 5 LEU A  75
LEU A  78
ALA A  81
VAL A 278
LEU A 197
EDO  A 403 (-3.7A)
None
None
None
None
1.06A 1s9pD-5o9wA:
undetectable
1s9pD-5o9wA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK


(Mycoplasma
genitalium)
no annotation 5 LEU A 103
LEU A 106
ALA A 110
LEU A  31
ILE A 123
None
1.04A 1s9pD-5obuA:
undetectable
1s9pD-5obuA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obw CHAPERONE PROTEIN
DNAK


(Mycoplasma
genitalium)
no annotation 5 LEU A 103
LEU A 106
ALA A 110
LEU A  31
ILE A 123
None
1.06A 1s9pD-5obwA:
undetectable
1s9pD-5obwA:
17.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
7 LEU A 298
ALA A 302
GLU A 305
MET A 336
LEU A 339
ARG A 346
HIS A 475
EST  A 601 (-4.1A)
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
EST  A 601 (-4.1A)
EST  A 601 (-4.4A)
0.40A 1s9pD-5toaA:
28.8
1s9pD-5toaA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uai METHIONYL-TRNA
FORMYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C)
6 LEU A 172
LEU A 175
ALA A 179
GLU A 182
LEU A 153
LEU A 114
None
1.35A 1s9pD-5uaiA:
undetectable
1s9pD-5uaiA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm9 RV0078

(Mycobacterium
tuberculosis)
no annotation 5 LEU A 159
ALA A 166
LEU A 191
LEU A 199
ILE A 142
LEU  A 159 ( 0.6A)
ALA  A 166 ( 0.0A)
LEU  A 191 ( 0.5A)
LEU  A 199 ( 0.6A)
ILE  A 142 ( 0.7A)
1.13A 1s9pD-5wm9A:
undetectable
1s9pD-5wm9A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq0 STAGE 0 SPORULATION
PROTEIN


(Paenisporosarcina
sp. TG-14)
no annotation 5 LEU B  15
ALA B   9
LEU B  53
VAL B   6
LEU B 115
None
1.00A 1s9pD-5wq0B:
undetectable
1s9pD-5wq0B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-)
no annotation 5 LEU A 755
LEU A 752
ALA A 749
VAL A 562
ILE A 464
None
1.15A 1s9pD-6d95A:
undetectable
1s9pD-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB)
no annotation 5 LEU A1006
LEU A 842
VAL A 829
TYR A 831
ILE A 937
None
1.09A 1s9pD-6etzA:
undetectable
1s9pD-6etzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezn DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT WBP1


(Saccharomyces
cerevisiae)
no annotation 5 LEU G 364
GLU G 252
ARG G 167
HIS G 307
ILE G 264
None
1.06A 1s9pD-6eznG:
undetectable
1s9pD-6eznG:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-)
no annotation 5 ALA A 233
LEU A 253
VAL A 251
LEU A 186
ILE A 138
None
1.07A 1s9pD-6gu8A:
undetectable
1s9pD-6gu8A:
undetectable