SIMILAR PATTERNS OF AMINO ACIDS FOR 1S9P_C_DESC500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e32 P97

(Mus musculus)
PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
5 LEU A 411
LEU A 414
CYH A 415
ALA A 418
MET A 449
None
0.70A 1s9pC-1e32A:
undetectable
1s9pC-1e32A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)


(Paracoccus
denitrificans)
PF01012
(ETF)
5 LEU B  99
LEU B 105
ALA B 106
LEU B 139
VAL B 177
None
1.07A 1s9pC-1efpB:
undetectable
1s9pC-1efpB:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Thermotoga
maritima)
PF01380
(SIS)
5 LEU A 156
LEU A 159
LEU A 162
ALA A 163
LEU A  66
None
1.02A 1s9pC-1j5xA:
undetectable
1s9pC-1j5xA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khy CLPB PROTEIN

(Escherichia
coli)
PF02861
(Clp_N)
5 LEU A 110
LEU A 113
ALA A 114
GLU A 117
LEU A  93
None
0.94A 1s9pC-1khyA:
undetectable
1s9pC-1khyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lb3 FERRITIN LIGHT CHAIN
1


(Mus musculus)
PF00210
(Ferritin)
5 LEU A 120
LEU A 117
LEU A 114
ALA A 113
LEU A  26
None
0.68A 1s9pC-1lb3A:
undetectable
1s9pC-1lb3A:
25.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 346
LEU A 349
ALA A 350
GLU A 353
LEU A 387
ARG A 394
EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
EST  A   1 (-3.7A)
0.33A 1s9pC-1pcgA:
27.4
1s9pC-1pcgA:
36.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G


(Homo sapiens)
PF02020
(W2)
PF02847
(MA3)
5 LEU A1532
LEU A1529
LEU A1526
ALA A1525
LEU A1516
None
0.93A 1s9pC-1ug3A:
undetectable
1s9pC-1ug3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G


(Homo sapiens)
PF02020
(W2)
PF02847
(MA3)
5 LEU A1532
LEU A1529
LEU A1526
ALA A1525
VAL A1555
None
1.01A 1s9pC-1ug3A:
undetectable
1s9pC-1ug3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE


(Thermus
thermophilus)
PF02570
(CbiC)
5 LEU A 197
LEU A 200
LEU A 203
ALA A 204
ILE A  69
None
0.77A 1s9pC-1v9cA:
undetectable
1s9pC-1v9cA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvt HYPOTHETICAL PROTEIN
ST2180


(Sulfurisphaera
tokodaii)
PF01923
(Cob_adeno_trans)
5 LEU A  36
LEU A  33
LEU A  30
ALA A  29
LEU A 129
None
0.92A 1s9pC-1wvtA:
undetectable
1s9pC-1wvtA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wym TRANSGELIN-2

(Homo sapiens)
PF00307
(CH)
5 LEU A 121
LEU A 124
LEU A 127
ALA A 128
ILE A  26
None
1.02A 1s9pC-1wymA:
undetectable
1s9pC-1wymA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1


(Homo sapiens)
PF00104
(Hormone_recep)
8 LEU A 324
CYH A 325
LEU A 327
GLU A 331
MET A 362
LEU A 365
VAL A 369
ARG A 372
None
0.41A 1s9pC-1xb7A:
28.9
1s9pC-1xb7A:
58.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN


(Homo sapiens)
PF00102
(Y_phosphatase)
5 LEU A1157
LEU A1160
ALA A1164
LEU A 897
VAL A 895
None
0.86A 1s9pC-1yguA:
undetectable
1s9pC-1yguA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh8 OXIDOREDUCTASE

(Thermotoga
maritima)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 LEU A 305
LEU A 308
ALA A 309
GLU A 312
LEU A 327
None
1.08A 1s9pC-1zh8A:
undetectable
1s9pC-1zh8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN


(Neisseria
meningitidis)
PF00359
(PTS_EIIA_2)
5 LEU A 114
LEU A 117
LEU A 120
ALA A 121
LEU A  59
None
0.90A 1s9pC-2a0jA:
undetectable
1s9pC-2a0jA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aja ANKYRIN REPEAT
FAMILY PROTEIN


(Legionella
pneumophila)
no annotation 6 LEU A 144
LEU A 147
CYH A 148
LEU A 150
ALA A 151
GLU A 119
None
1.29A 1s9pC-2ajaA:
undetectable
1s9pC-2ajaA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aja ANKYRIN REPEAT
FAMILY PROTEIN


(Legionella
pneumophila)
no annotation 5 LEU A 179
LEU A 182
CYH A 183
LEU A 185
ALA A 186
None
0.88A 1s9pC-2ajaA:
undetectable
1s9pC-2ajaA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 701
LEU A 704
LEU A 707
MET A 742
ARG A 752
None
BHM  A   1 (-4.0A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
0.59A 1s9pC-2ax9A:
26.4
1s9pC-2ax9A:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)


(Bluetongue
virus)
no annotation 5 LEU P 310
LEU P 313
LEU P 316
ALA P 317
ILE P 267
None
0.56A 1s9pC-2btvP:
undetectable
1s9pC-2btvP:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2g THREONINE SYNTHASE

(Arabidopsis
thaliana)
PF00291
(PALP)
5 LEU A 415
LEU A 412
LEU A 409
ALA A 408
ILE A 378
None
1.02A 1s9pC-2c2gA:
undetectable
1s9pC-2c2gA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE


(Thermus
thermophilus)
PF01053
(Cys_Met_Meta_PP)
5 LEU A 159
LEU A 162
LEU A 165
ALA A 166
VAL A  99
None
0.98A 1s9pC-2cb1A:
undetectable
1s9pC-2cb1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486


(Thermus
thermophilus)
PF01894
(UPF0047)
5 LEU A  60
LEU A  63
LEU A  66
ALA A  67
LEU A  85
None
0.95A 1s9pC-2cu5A:
undetectable
1s9pC-2cu5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2c UBIQUITIN
CONJUGATING ENZYME


(Spisula
solidissima)
PF00179
(UQ_con)
5 LEU A 132
LEU A 135
LEU A 138
VAL A 107
ILE A  50
None
1.07A 1s9pC-2e2cA:
undetectable
1s9pC-2e2cA:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
10 LEU A 265
LEU A 268
LEU A 271
ALA A 272
GLU A 275
MET A 306
LEU A 309
VAL A 313
ARG A 316
TYR A 326
None
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
None
OHT  A 500 (-3.8A)
OHT  A 500 (-4.5A)
0.38A 1s9pC-2gpvA:
34.3
1s9pC-2gpvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
8 LEU A 265
LEU A 268
MET A 306
LEU A 309
VAL A 313
ARG A 316
TYR A 326
ILE A 438
None
OHT  A 500 (-4.1A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
None
OHT  A 500 (-3.8A)
OHT  A 500 (-4.5A)
None
0.71A 1s9pC-2gpvA:
34.3
1s9pC-2gpvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
8 LEU A 268
CYH A 269
LEU A 271
ALA A 272
GLU A 275
MET A 306
LEU A 309
ARG A 316
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.7A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
0.62A 1s9pC-2gpvA:
34.3
1s9pC-2gpvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7n TALIN-1

(Mus musculus)
no annotation 5 LEU A1105
LEU A1106
ALA A1103
VAL A1192
ILE A1119
None
1.07A 1s9pC-2l7nA:
undetectable
1s9pC-2l7nA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7t TRANSCRIPTIONAL
REGULATOR


(Corynebacterium
glutamicum)
PF00440
(TetR_N)
5 LEU A 130
LEU A 133
ALA A 134
VAL A  84
ILE A 150
None
None
None
None
UNL  A 200 ( 4.3A)
1.03A 1s9pC-2o7tA:
undetectable
1s9pC-2o7tA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 346
LEU A 349
ALA A 350
GLU A 353
LEU A 387
ARG A 394
EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
0.49A 1s9pC-2ocfA:
28.3
1s9pC-2ocfA:
31.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
5 CYH A 197
LEU A 199
ALA A 200
LEU A 258
ILE A 221
None
1.07A 1s9pC-2pmiA:
undetectable
1s9pC-2pmiA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Caldanaerobacter
subterraneus)
PF03009
(GDPD)
5 LEU A 214
LEU A 192
LEU A 171
ARG A 186
ILE A 199
None
1.07A 1s9pC-2pz0A:
undetectable
1s9pC-2pz0A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR


(unidentified)
PF00104
(Hormone_recep)
6 LEU A  29
LEU A  32
LEU A  35
ALA A  36
MET A  70
ARG A  80
1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
0.46A 1s9pC-2q3yA:
26.6
1s9pC-2q3yA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa)
PF00753
(Lactamase_B)
6 LEU A 208
LEU A 205
LEU A 202
VAL A 194
TYR A 201
ILE A 154
None
1.38A 1s9pC-2vw8A:
undetectable
1s9pC-2vw8A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE


(Nonomuraea
gerenzanensis)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 LEU A 179
ALA A 416
LEU A 502
VAL A 505
ILE A 160
None
0.90A 1s9pC-2wdwA:
undetectable
1s9pC-2wdwA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA


(Escherichia
coli)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
5 LEU A 478
LEU A 481
LEU A 484
ALA A 485
ILE A 547
None
1.05A 1s9pC-2xaxA:
undetectable
1s9pC-2xaxA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT


(Desulfomicrobium
norvegicum)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 LEU A 115
LEU A 118
CYH A 119
LEU A 121
VAL A 100
None
1.05A 1s9pC-2xsjA:
undetectable
1s9pC-2xsjA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0m PROBABLE HISTONE
ACETYLTRANSFERASE
MYST1


(Homo sapiens)
PF01853
(MOZ_SAS)
5 LEU A 263
CYH A 264
LEU A 266
ALA A 267
LEU A 318
None
ALY  A 274 ( 3.4A)
None
ALY  A 274 ( 4.0A)
ACO  A1450 (-4.2A)
0.81A 1s9pC-2y0mA:
undetectable
1s9pC-2y0mA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 LEU A 150
ALA A 390
LEU A 476
VAL A 479
ILE A 131
None
0.87A 1s9pC-2y3sA:
undetectable
1s9pC-2y3sA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za8 FERRITIN LIGHT CHAIN

(Equus caballus)
PF00210
(Ferritin)
5 LEU A 117
LEU A 114
LEU A 111
ALA A 110
LEU A  23
None
0.86A 1s9pC-2za8A:
undetectable
1s9pC-2za8A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ


(Bacteroides
thetaiotaomicron)
PF00884
(Sulfatase)
PF16347
(DUF4976)
5 LEU A 335
LEU A 338
CYH A 339
LEU A 341
ALA A 342
None
1.07A 1s9pC-3b5qA:
undetectable
1s9pC-3b5qA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571


(Deinococcus
radiodurans)
PF01266
(DAO)
5 LEU A 384
LEU A 390
ALA A 391
LEU A  55
VAL A  41
None
0.75A 1s9pC-3c4nA:
undetectable
1s9pC-3c4nA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE


(Corynebacterium
diphtheriae)
PF00155
(Aminotran_1_2)
5 LEU A 171
LEU A 174
CYH A 175
LEU A 177
ALA A 178
None
0.69A 1s9pC-3fdbA:
undetectable
1s9pC-3fdbA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE


(Bartonella
henselae)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
5 LEU A 149
LEU A  65
ALA A 123
LEU A 109
ILE A 147
None
0.98A 1s9pC-3girA:
undetectable
1s9pC-3girA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl5 PUTATIVE DSBA
OXIDOREDUCTASE
SCO1869


(Streptomyces
coelicolor)
PF01323
(DSBA)
5 LEU A 101
LEU A 104
LEU A 107
ALA A 108
ILE A   9
None
0.83A 1s9pC-3gl5A:
undetectable
1s9pC-3gl5A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 LEU A 439
LEU A 442
LEU A 445
ALA A 446
LEU A 236
None
0.91A 1s9pC-3hz6A:
undetectable
1s9pC-3hz6A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kba PROGESTERONE
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 715
LEU A 718
LEU A 721
MET A 756
ARG A 766
WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
0.49A 1s9pC-3kbaA:
25.4
1s9pC-3kbaA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myf SENSOR PROTEIN

(Shewanella sp.
W3-18-1)
PF01627
(Hpt)
5 LEU A 833
LEU A 830
LEU A 827
ALA A 826
LEU A 816
None
1.08A 1s9pC-3myfA:
undetectable
1s9pC-3myfA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncc PROLACTIN

(Homo sapiens)
PF00103
(Hormone_1)
5 LEU A  15
LEU A  18
ALA A  22
LEU A 126
ILE A 193
None
1.05A 1s9pC-3nccA:
undetectable
1s9pC-3nccA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P


(Drosophila
melanogaster)
PF11701
(UNC45-central)
5 LEU A 637
CYH A 638
LEU A 640
ALA A 641
MET A 681
None
1.00A 1s9pC-3nowA:
undetectable
1s9pC-3nowA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm9 PUTATIVE
OXIDOREDUCTASE


(Rhodopseudomonas
palustris)
PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C)
5 LEU A 247
LEU A 244
ALA A 243
LEU A 263
ILE A 308
None
1.05A 1s9pC-3pm9A:
undetectable
1s9pC-3pm9A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N


(Escherichia
coli)
no annotation 5 LEU N  79
LEU N  82
LEU N  85
ALA N  86
ILE N 248
LFA  N 488 ( 4.8A)
None
None
None
None
0.99A 1s9pC-3rkoN:
undetectable
1s9pC-3rkoN:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1


(synthetic
construct)
PF00104
(Hormone_recep)
5 LEU A  29
LEU A  32
LEU A  35
MET A  70
ARG A  80
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
0.45A 1s9pC-3ry9A:
26.8
1s9pC-3ry9A:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli)
PF02395
(Peptidase_S6)
5 LEU A 762
LEU A 794
ALA A 812
VAL A 850
ILE A 738
None
1.01A 1s9pC-3szeA:
undetectable
1s9pC-3szeA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE


(Oryza sativa)
PF00875
(DNA_photolyase)
5 LEU A  94
LEU A  97
LEU A 100
ALA A 101
VAL A  72
None
1.01A 1s9pC-3umvA:
undetectable
1s9pC-3umvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axv MPAA

(Vibrio
campbellii)
PF04952
(AstE_AspA)
5 LEU A 146
LEU A 143
LEU A 140
ALA A 139
LEU A  28
None
0.96A 1s9pC-4axvA:
undetectable
1s9pC-4axvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2g GH3-1 AUXIN
CONJUGATING ENZYME


(Vitis vinifera)
PF03321
(GH3)
5 LEU A 505
CYH A 509
LEU A 511
ALA A 512
GLU A 515
None
1.05A 1s9pC-4b2gA:
undetectable
1s9pC-4b2gA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0n A-KINASE ANCHOR
PROTEIN 13


(Homo sapiens)
PF00169
(PH)
PF00621
(RhoGEF)
5 LEU B2141
LEU B2149
CYH B2146
LEU B2148
ILE B2019
None
1.04A 1s9pC-4d0nB:
undetectable
1s9pC-4d0nB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
5 LEU A 645
LEU A 648
LEU A 651
ALA A 652
TYR A 609
None
0.59A 1s9pC-4fddA:
undetectable
1s9pC-4fddA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL


(Homo sapiens)
PF00067
(p450)
5 LEU A 324
LEU A 327
LEU A 330
ALA A 331
ARG A 341
None
0.78A 1s9pC-4fdhA:
undetectable
1s9pC-4fdhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI


(Escherichia
coli)
PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C)
5 LEU A 300
LEU A 303
LEU A 306
ALA A 307
GLU A 412
None
1.02A 1s9pC-4im7A:
undetectable
1s9pC-4im7A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1


(Homo sapiens)
PF00169
(PH)
6 LEU A 639
ALA A 643
GLU A 612
MET A 651
VAL A 666
ARG A 669
None
1.46A 1s9pC-4k2pA:
undetectable
1s9pC-4k2pA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3


(Homo sapiens)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV)
5 LEU C 342
LEU C 378
LEU C 411
LEU C 427
ILE C 338
None
1.06A 1s9pC-4leoC:
undetectable
1s9pC-4leoC:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
8 LEU A 280
LEU A 283
LEU A 286
ALA A 287
GLU A 290
MET A 321
LEU A 324
ARG A 331
None
0.48A 1s9pC-4n1yA:
28.5
1s9pC-4n1yA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE


(Geobacter
sulfurreducens)
PF00171
(Aldedh)
PF01619
(Pro_dh)
5 LEU A 275
LEU A 304
ALA A 356
VAL A 366
ILE A 273
None
None
P5F  A1101 ( 3.7A)
None
None
0.91A 1s9pC-4nmeA:
undetectable
1s9pC-4nmeA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4poo PUTATIVE RNA
METHYLASE


(Bacillus
subtilis)
PF06962
(rRNA_methylase)
5 LEU A  13
LEU A 135
ALA A  98
LEU A 126
ILE A 183
None
1.05A 1s9pC-4pooA:
undetectable
1s9pC-4pooA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3


(Thermobaculum
terrenum)
PF00271
(Helicase_C)
5 LEU A 203
CYH A 204
LEU A 206
ALA A 207
LEU A 212
None
1.06A 1s9pC-4q2cA:
undetectable
1s9pC-4q2cA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rn3 HAD SUPERFAMILY
HYDROLASE


(Geobacter
sulfurreducens)
PF13419
(HAD_2)
5 LEU A 154
LEU A 179
GLU A 175
LEU A 195
ILE A  14
None
1.06A 1s9pC-4rn3A:
undetectable
1s9pC-4rn3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
7 LEU A 766
LEU A 769
LEU A 772
ALA A 773
MET A 807
LEU A 810
ARG A 817
CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.5A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.7A)
0.58A 1s9pC-4udbA:
25.9
1s9pC-4udbA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN


(Tetrahymena
thermophila)
PF12317
(IFT46_B_C)
no annotation
5 LEU A 296
CYH A 300
LEU A 302
ALA A 303
LEU B 592
None
0.89A 1s9pC-4uzzA:
undetectable
1s9pC-4uzzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w9r UNCHARACTERIZED
PROTEIN


(Capnocytophaga
ochracea)
PF00756
(Esterase)
5 LEU A 313
LEU A 316
ALA A 317
TYR A 301
ILE A 342
None
0.89A 1s9pC-4w9rA:
undetectable
1s9pC-4w9rA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE


(Mycolicibacterium
smegmatis)
PF00933
(Glyco_hydro_3)
5 ALA A 208
LEU A 261
VAL A 267
ARG A 216
ILE A 192
None
1.06A 1s9pC-4yyfA:
undetectable
1s9pC-4yyfA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF


(Serratia sp.
FS14)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
5 LEU A 200
LEU A 203
LEU A 206
ALA A 207
LEU A 192
None
0.98A 1s9pC-5cioA:
undetectable
1s9pC-5cioA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czl GLUCANASE

(Raoultella
ornithinolytica)
PF01270
(Glyco_hydro_8)
5 LEU A 306
LEU A 309
LEU A 312
ALA A 313
ARG A 106
None
0.91A 1s9pC-5czlA:
undetectable
1s9pC-5czlA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d91 AF2299
PROTEIN,PHOSPHATIDYL
INOSITOL SYNTHASE


(Archaeoglobus
fulgidus;
Renibacterium
salmoninarum)
PF01066
(CDP-OH_P_transf)
5 LEU A 174
LEU A 177
LEU A 180
ALA A 181
LEU A 125
8K6  A 337 ( 4.9A)
None
None
None
None
0.99A 1s9pC-5d91A:
undetectable
1s9pC-5d91A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG


(Homo sapiens)
PF02724
(CDC45)
5 LEU A 564
LEU A 561
LEU A 558
MET A 537
LEU A 549
SO4  A 607 ( 4.9A)
None
None
None
None
0.61A 1s9pC-5dgoA:
undetectable
1s9pC-5dgoA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG


(Homo sapiens)
PF02724
(CDC45)
5 LEU A 564
LEU A 561
LEU A 558
MET A 537
VAL A 506
SO4  A 607 ( 4.9A)
None
None
None
None
0.88A 1s9pC-5dgoA:
undetectable
1s9pC-5dgoA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus)
no annotation 5 LEU B 296
LEU B 299
LEU B 302
ALA B 303
ILE B 344
None
1.00A 1s9pC-5dlqB:
undetectable
1s9pC-5dlqB:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 LEU A 462
LEU A 459
LEU A 456
ALA A 455
LEU A 429
None
1.04A 1s9pC-5dqfA:
undetectable
1s9pC-5dqfA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5euf PROTEASE

(Helicobacter
pylori)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
5 LEU A 300
LEU A 297
ALA A 296
LEU A 419
VAL A 421
None
1.04A 1s9pC-5eufA:
undetectable
1s9pC-5eufA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
PAXT-1


(Caenorhabditis
elegans)
PF03159
(XRN_N)
PF11952
(XTBD)
6 LEU B  45
LEU B  42
CYH B  41
LEU B  39
TYR B  34
ILE A 652
None
1.34A 1s9pC-5firB:
undetectable
1s9pC-5firB:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwm HEAT SHOCK PROTEIN
HSP 90 BETA


(Homo sapiens)
PF00183
(HSP90)
PF02518
(HATPase_c)
5 LEU A 563
CYH A 564
LEU A 566
VAL A 651
ILE A 580
None
1.06A 1s9pC-5fwmA:
undetectable
1s9pC-5fwmA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum)
PF08801
(Nucleoporin_N)
5 LEU A 763
LEU A 760
LEU A 757
ALA A 756
LEU A 669
None
0.92A 1s9pC-5haxA:
undetectable
1s9pC-5haxA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum)
PF08801
(Nucleoporin_N)
5 LEU A 763
LEU A 760
LEU A 757
GLU A 753
LEU A 669
None
0.79A 1s9pC-5haxA:
undetectable
1s9pC-5haxA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb1 NUCLEOPORIN NUP170

(Chaetomium
thermophilum)
PF03177
(Nucleoporin_C)
5 LEU A 763
LEU A 760
LEU A 757
ALA A 756
LEU A 669
None
1.04A 1s9pC-5hb1A:
undetectable
1s9pC-5hb1A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb1 NUCLEOPORIN NUP170

(Chaetomium
thermophilum)
PF03177
(Nucleoporin_C)
5 LEU A 763
LEU A 760
LEU A 757
GLU A 753
LEU A 669
None
0.83A 1s9pC-5hb1A:
undetectable
1s9pC-5hb1A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxk ZINC-DEPENDENT
PEPTIDASE


(Thermus
thermophilus)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
5 LEU A 129
LEU A 126
LEU A 123
ALA A 122
LEU A  46
LEU  A 129 ( 0.5A)
LEU  A 126 ( 0.6A)
LEU  A 123 ( 0.6A)
ALA  A 122 ( 0.0A)
LEU  A  46 ( 0.6A)
1.00A 1s9pC-5hxkA:
undetectable
1s9pC-5hxkA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0l DESIGNED PROTEIN
3L6HC2_2


(synthetic
construct)
no annotation 5 LEU A  48
LEU A  51
ALA A  55
GLU A  58
ILE A  39
None
1.06A 1s9pC-5j0lA:
undetectable
1s9pC-5j0lA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lg8 FERRITIN LIGHT CHAIN

(Homo sapiens)
PF00210
(Ferritin)
5 LEU A 120
LEU A 117
LEU A 114
ALA A 113
LEU A  26
None
0.74A 1s9pC-5lg8A:
undetectable
1s9pC-5lg8A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2


(Eremothecium
gossypii)
PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C)
5 LEU A1049
LEU A1052
ALA A1053
LEU A1023
ILE A1098
None
1.07A 1s9pC-5me3A:
undetectable
1s9pC-5me3A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
no annotation 6 LEU A 766
LEU A 769
LEU A 772
ALA A 773
MET A 807
ARG A 817
ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.8A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
0.56A 1s9pC-5mwpA:
27.0
1s9pC-5mwpA:
16.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
7 LEU A 298
LEU A 301
ALA A 302
GLU A 305
MET A 336
LEU A 339
ARG A 346
EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
EST  A 601 (-4.1A)
0.32A 1s9pC-5toaA:
28.2
1s9pC-5toaA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)


(uncultured
bacterium)
PF01494
(FAD_binding_3)
5 LEU A 306
LEU A 312
ALA A 313
LEU A  23
VAL A   9
None
0.96A 1s9pC-5tulA:
undetectable
1s9pC-5tulA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN K


(Pseudomonas
aeruginosa)
no annotation 5 LEU X 196
LEU X 194
ALA X 166
GLU X 167
ILE X 142
None
None
None
CA  X 403 ( 2.2A)
None
0.98A 1s9pC-5vtmX:
undetectable
1s9pC-5vtmX:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhm FERRITIN, MIDDLE
SUBUNIT


(Rana
catesbeiana)
PF00210
(Ferritin)
5 LEU A 116
LEU A 113
LEU A 110
ALA A 109
LEU A  22
None
0.69A 1s9pC-5xhmA:
undetectable
1s9pC-5xhmA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194)
5 LEU C1915
LEU C1918
CYH C1919
ALA C1922
GLU C1925
None
0.42A 1s9pC-5y3rC:
undetectable
1s9pC-5y3rC:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C)
no annotation 5 LEU 2 235
LEU 2 238
LEU 2 241
ALA 2 242
GLU 2 255
None
1.06A 1s9pC-5zvs2:
undetectable
1s9pC-5zvs2:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bar ROD SHAPE
DETERMINING PROTEIN
RODA


(Thermus
thermophilus)
no annotation 5 LEU A 112
LEU A 115
LEU A 118
ALA A 119
LEU A 298
None
1.05A 1s9pC-6barA:
undetectable
1s9pC-6barA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brs PUTATIVE ZINC
PROTEASE


(Pectobacterium
atrosepticum)
no annotation 5 LEU A 826
LEU A 829
ALA A 833
GLU A 836
ILE A 794
None
0.88A 1s9pC-6brsA:
undetectable
1s9pC-6brsA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9


(Danio rerio)
no annotation 5 LEU C 500
CYH C 501
LEU C 503
ALA C 504
ILE C 198
None
0.86A 1s9pC-6c08C:
2.3
1s9pC-6c08C:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN


(Escherichia
coli;
Homo sapiens)
no annotation 5 LEU R 125
LEU R 128
LEU R 131
ALA R 132
TYR R 306
None
0.88A 1s9pC-6cmoR:
undetectable
1s9pC-6cmoR:
16.82