SIMILAR PATTERNS OF AMINO ACIDS FOR 1S9P_B_DESB459_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b89 PROTEIN (CLATHRIN
HEAVY CHAIN)

(Bos taurus) 		PF00637
(Clathrin) 		5 LEU A1430
LEU A1445
VAL A1442
TYR A1438
LEU A1419
 None
 1.29A 1s9pB-1b89A:
undetectable		 1s9pB-1b89A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		5 LEU A 139
CYH A 143
LEU A 145
ALA A 146
PHE A 160
 None
 1.28A 1s9pB-1dubA:
undetectable		 1s9pB-1dubA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF01012
(ETF) 		5 LEU B  99
LEU B 105
ALA B 106
LEU B 139
VAL B 177
 None
 1.05A 1s9pB-1efpB:
undetectable		 1s9pB-1efpB:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 LEU A  74
GLU A  71
VAL A  10
LEU A 189
PHE A  63
 None
 1.17A 1s9pB-1f4hA:
undetectable		 1s9pB-1f4hA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcb GAL6 HG (EMTS)
DERIVATIVE

(Saccharomyces
cerevisiae) 		PF03051
(Peptidase_C1_2) 		5 LEU A 102
ALA A  77
VAL A 419
TYR A 145
LEU A 263
 None
None
None
None
GOL  A 851 ( 4.9A)
 1.20A 1s9pB-1gcbA:
undetectable		 1s9pB-1gcbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k38 BETA-LACTAMASE OXA-2

(Salmonella
enterica) 		PF00905
(Transpeptidase) 		5 LEU A  75
ALA A  82
VAL A 119
TYR A 120
LEU A 191
 None
None
None
KCX  A  70 ( 3.7A)
None
 1.03A 1s9pB-1k38A:
undetectable		 1s9pB-1k38A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khy CLPB PROTEIN

(Escherichia
coli) 		PF02861
(Clp_N) 		5 LEU A  38
LEU A 113
ALA A 114
LEU A  93
LEU A   6
 None
 1.19A 1s9pB-1khyA:
undetectable		 1s9pB-1khyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		5 ALA A 176
VAL A 144
TYR A 137
LEU A 132
PHE A 153
 None
 1.18A 1s9pB-1kyhA:
undetectable		 1s9pB-1kyhA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1d GLUTAMATE RECEPTOR
INTERACTING PROTEIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 LEU A 138
ALA A 165
LEU A 130
VAL A 204
LEU A 177
 None
 1.15A 1s9pB-1p1dA:
undetectable		 1s9pB-1p1dA:
21.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 349
ALA A 350
GLU A 353
LEU A 387
ARG A 394
 EST  A   1 ( 4.8A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
EST  A   1 (-3.7A)
 0.32A 1s9pB-1pcgA:
27.6		 1s9pB-1pcgA:
36.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Pseudomonas
putida) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 388
CYH A 392
ALA A 395
GLU A 398
LEU A 421
 None
 1.12A 1s9pB-1re5A:
undetectable		 1s9pB-1re5A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		5 LEU A 479
CYH A 483
ALA A 486
LEU A  32
VAL A  18
 None
 1.07A 1s9pB-1sezA:
undetectable		 1s9pB-1sezA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU B  18
ALA B  12
LEU B 333
VAL B 187
LEU B 234
 None
 1.21A 1s9pB-1tqyB:
undetectable		 1s9pB-1tqyB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		5 LEU A  93
MET A 171
LEU A  68
VAL A 107
LEU A  55
 None
 1.23A 1s9pB-1v8dA:
undetectable		 1s9pB-1v8dA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 LEU A 116
LEU A 133
VAL A 154
LEU A 126
PHE A  59
 None
 1.30A 1s9pB-1vm7A:
undetectable		 1s9pB-1vm7A:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 CYH A 325
LEU A 327
GLU A 331
MET A 362
LEU A 365
VAL A 369
ARG A 372
LEU A 401
 None
 0.55A 1s9pB-1xb7A:
29.5		 1s9pB-1xb7A:
58.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLU A 331
LEU A 365
VAL A 369
ARG A 372
LEU A 398
 None
 1.25A 1s9pB-1xb7A:
29.5		 1s9pB-1xb7A:
58.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt3 RIBONUCLEASE D

(Escherichia
coli) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		5 LEU A 328
ALA A 329
LEU A 353
LEU A 369
PHE A 307
 None
 1.13A 1s9pB-1yt3A:
undetectable		 1s9pB-1yt3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1u ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT

(Homo sapiens) 		PF01012
(ETF) 		5 LEU B 102
LEU B 108
ALA B 109
LEU B 142
VAL B 180
 None
 1.11A 1s9pB-2a1uB:
undetectable		 1s9pB-2a1uB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aja ANKYRIN REPEAT
FAMILY PROTEIN

(Legionella
pneumophila) 		no annotation 5 LEU A 144
CYH A 148
LEU A 150
ALA A 151
GLU A 119
 None
 1.29A 1s9pB-2ajaA:
undetectable		 1s9pB-2ajaA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayi AMINOPEPTIDASE T

(Thermus
thermophilus) 		PF02073
(Peptidase_M29) 		5 LEU A  20
CYH A 242
LEU A 241
ALA A 233
LEU A  14
 None
 1.26A 1s9pB-2ayiA:
undetectable		 1s9pB-2ayiA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c27 MYCOTHIOL SYNTHASE

(Mycobacterium
tuberculosis) 		PF00583
(Acetyltransf_1) 		5 ALA A 244
LEU A 218
VAL A 169
ARG A 168
LEU A 238
 None
None
None
None
COA  A1314 (-4.5A)
 1.17A 1s9pB-2c27A:
undetectable		 1s9pB-2c27A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A 268
LEU A 274
ALA A 275
LEU A  98
LEU A 259
 None
 0.94A 1s9pB-2dsjA:
undetectable		 1s9pB-2dsjA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR

(Molluscum
contagiosum
virus) 		PF01335
(DED) 		5 LEU A 117
CYH A 120
LEU A 122
LEU A 143
LEU A 112
 None
 1.30A 1s9pB-2f1sA:
undetectable		 1s9pB-2f1sA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 LEU A 326
GLU A 373
LEU A 380
ARG A 387
PHE A 406
 None
 1.24A 1s9pB-2ffhA:
undetectable		 1s9pB-2ffhA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvz INOSITOL
MONOPHOSPHATASE 2

(Homo sapiens) 		PF00459
(Inositol_P) 		5 LEU A 209
CYH A 212
LEU A 214
VAL A 261
TYR A 222
 None
 1.05A 1s9pB-2fvzA:
undetectable		 1s9pB-2fvzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		5 LEU A 292
CYH A 219
ALA A 222
LEU A 346
PHE A 408
 None
 1.15A 1s9pB-2g02A:
undetectable		 1s9pB-2g02A:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 CYH A 269
LEU A 271
ALA A 272
GLU A 275
LEU A 309
ARG A 316
LEU A 342
PHE A 435
 OHT  A 500 ( 4.7A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
OHT  A 500 (-3.7A)
 1.12A 1s9pB-2gpvA:
34.6		 1s9pB-2gpvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 CYH A 269
LEU A 271
ALA A 272
GLU A 275
MET A 306
LEU A 309
ARG A 316
PHE A 435
 OHT  A 500 ( 4.7A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 (-3.7A)
 0.83A 1s9pB-2gpvA:
34.6		 1s9pB-2gpvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 265
LEU A 271
ALA A 272
GLU A 275
MET A 306
LEU A 309
VAL A 313
ARG A 316
TYR A 326
LEU A 345
PHE A 435
 None
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
None
OHT  A 500 (-3.8A)
OHT  A 500 (-4.5A)
OHT  A 500 (-4.3A)
OHT  A 500 (-3.7A)
 0.58A 1s9pB-2gpvA:
34.6		 1s9pB-2gpvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 271
ALA A 272
GLU A 275
LEU A 309
VAL A 313
ARG A 316
TYR A 326
LEU A 342
PHE A 435
 OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
None
OHT  A 500 (-3.8A)
OHT  A 500 (-4.5A)
OHT  A 500 ( 4.7A)
OHT  A 500 (-3.7A)
 1.21A 1s9pB-2gpvA:
34.6		 1s9pB-2gpvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2q COFILIN

(Schizosaccharomyces
pombe) 		PF00241
(Cofilin_ADF) 		5 CYH A  12
ALA A  15
GLU A  18
LEU A  25
PHE A  30
 None
 1.30A 1s9pB-2i2qA:
undetectable		 1s9pB-2i2qA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		5 LEU A 458
ALA A 459
LEU A  28
VAL A  14
LEU A 237
 None
 1.03A 1s9pB-2ivdA:
undetectable		 1s9pB-2ivdA:
18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 349
ALA A 350
GLU A 353
LEU A 387
ARG A 394
 EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
 0.52A 1s9pB-2ocfA:
28.7		 1s9pB-2ocfA:
31.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		5 LEU A  60
LEU A  81
ALA A  97
LEU A 131
PHE A 140
 None
 0.97A 1s9pB-2q01A:
undetectable		 1s9pB-2q01A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  29
LEU A  35
ALA A  36
MET A  70
ARG A  80
 1CA  A 247 ( 3.6A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
 0.50A 1s9pB-2q3yA:
26.8		 1s9pB-2q3yA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rt5 MSX2-INTERACTING
PROTEIN

(Homo sapiens) 		PF07744
(SPOC) 		5 LEU A3533
ALA A3534
LEU A3576
VAL A3660
TYR A3573
 None
 1.26A 1s9pB-2rt5A:
undetectable		 1s9pB-2rt5A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rt5 MSX2-INTERACTING
PROTEIN

(Homo sapiens) 		PF07744
(SPOC) 		5 LEU A3533
LEU A3576
VAL A3660
TYR A3573
LEU A3642
 None
 1.26A 1s9pB-2rt5A:
undetectable		 1s9pB-2rt5A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 175
GLU A 172
LEU A 272
LEU A 317
PHE A 267
 None
 1.12A 1s9pB-2v55A:
undetectable		 1s9pB-2v55A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1j PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		5 LEU A 203
ALA A 130
LEU A  94
VAL A  85
LEU A 146
 None
 1.26A 1s9pB-2w1jA:
undetectable		 1s9pB-2w1jA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE

(Trypanosoma
brucei) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A  48
ALA A 159
LEU A 157
VAL A   8
LEU A 120
 None
FAD  A1491 (-4.7A)
None
None
None
 1.30A 1s9pB-2wbaA:
undetectable		 1s9pB-2wbaA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 LEU A 110
LEU A 115
ALA A 116
GLU A 119
TYR A 130
 None
 1.28A 1s9pB-2x3kA:
undetectable		 1s9pB-2x3kA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zg6 PUTATIVE
UNCHARACTERIZED
PROTEIN ST2620

(Sulfurisphaera
tokodaii) 		PF13419
(HAD_2) 		5 LEU A 128
LEU A 114
ALA A 115
LEU A   7
VAL A 170
 None
 1.30A 1s9pB-2zg6A:
undetectable		 1s9pB-2zg6A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 LEU A 185
ALA A 184
TYR A 191
LEU A 172
PHE A 148
 None
 1.21A 1s9pB-2zsuA:
undetectable		 1s9pB-2zsuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqw PUTATIVE CAPSID
PROTEIN OF PROPHAGE

(Escherichia
coli) 		PF03864
(Phage_cap_E) 		5 ALA A 197
MET A 207
LEU A 284
VAL A 348
LEU A 217
 None
 1.28A 1s9pB-3bqwA:
undetectable		 1s9pB-3bqwA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		5 LEU A 384
LEU A 390
ALA A 391
LEU A  55
VAL A  41
 None
 0.76A 1s9pB-3c4nA:
undetectable		 1s9pB-3c4nA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 LEU A 492
ALA A 380
VAL A 438
ARG A 375
LEU A 474
 None
 1.14A 1s9pB-3djlA:
undetectable		 1s9pB-3djlA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 LEU A 308
LEU A 389
LEU A 381
TYR A 393
LEU A 260
 None
 1.28A 1s9pB-3dwbA:
undetectable		 1s9pB-3dwbA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		5 CYH A 368
LEU A 370
ALA A 366
MET A 228
LEU A 465
 None
 1.27A 1s9pB-3fdhA:
undetectable		 1s9pB-3fdhA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6z POLYCOMB PROTEIN
SFMBT

(Drosophila
melanogaster) 		PF02820
(MBT) 		5 LEU A 609
ALA A 629
VAL A 966
LEU A 539
PHE A 622
 None
 1.17A 1s9pB-3h6zA:
undetectable		 1s9pB-3h6zA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 130
LEU A 160
ALA A 111
LEU A  18
LEU A 100
 None
 1.29A 1s9pB-3h8fA:
undetectable		 1s9pB-3h8fA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if6 OXA-46 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		5 LEU C  80
ALA C  87
VAL C 124
TYR C 125
LEU C 196
 None
None
None
KCX  C  75 ( 3.6A)
None
 1.09A 1s9pB-3if6C:
undetectable		 1s9pB-3if6C:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsz GLUTATHIONE
S-TRANSFERASE

(Rhodobacter
sphaeroides) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A 174
ALA A 175
LEU A 198
VAL A 194
PHE A 167
 None
 1.30A 1s9pB-3lszA:
undetectable		 1s9pB-3lszA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		5 LEU X1193
LEU X1199
ALA X1200
LEU X1141
VAL X1134
 None
 1.28A 1s9pB-3lxuX:
undetectable		 1s9pB-3lxuX:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 LEU A 233
LEU A 227
ALA A 226
LEU A 277
LEU A 434
 None
 1.19A 1s9pB-3mcxA:
undetectable		 1s9pB-3mcxA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE

(Clostridioides
difficile) 		PF06050
(HGD-D) 		5 LEU B 260
LEU B 233
VAL B 255
ARG B 193
PHE B 319
 None
 1.25A 1s9pB-3o3mB:
undetectable		 1s9pB-3o3mB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 LEU A 172
ALA A 169
LEU A 245
LEU A 288
PHE A 275
 None
 1.22A 1s9pB-3oqnA:
undetectable		 1s9pB-3oqnA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 LEU X 217
ALA X 261
MET X 247
VAL X 336
LEU X 220
 None
 1.30A 1s9pB-3pb9X:
undetectable		 1s9pB-3pb9X:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 LEU A 430
LEU A 450
LEU A 474
ARG A 504
LEU A 438
 None
 1.29A 1s9pB-3pocA:
undetectable		 1s9pB-3pocA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0g ENOYL-COA HYDRATASE
ECHA8

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 LEU A 106
CYH A 110
LEU A 112
ALA A 113
PHE A 127
 None
 1.30A 1s9pB-3q0gA:
undetectable		 1s9pB-3q0gA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Salmonella
enterica) 		PF04131
(NanE) 		5 LEU A  88
LEU A  94
ALA A  95
LEU A 127
LEU A 119
 None
 1.00A 1s9pB-3q58A:
undetectable		 1s9pB-3q58A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans) 		PF00221
(Lyase_aromatic) 		5 LEU A 391
LEU A 385
ALA A 384
LEU A 336
LEU A 244
 None
 1.09A 1s9pB-3unvA:
undetectable		 1s9pB-3unvA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 LEU A  25
CYH A  29
LEU A  31
VAL A  49
LEU A  73
 None
 1.26A 1s9pB-4a6eA:
undetectable		 1s9pB-4a6eA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avc LYSINE
ACETYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		5 ALA A 135
LEU A 139
VAL A 328
TYR A 204
LEU A 162
 PEG  A1335 (-3.9A)
None
None
None
None
 1.09A 1s9pB-4avcA:
undetectable		 1s9pB-4avcA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL

(Homo sapiens) 		PF00481
(PP2C) 		5 LEU A 116
ALA A 193
LEU A 293
VAL A 342
LEU A  92
 None
 1.26A 1s9pB-4da1A:
undetectable		 1s9pB-4da1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4g (3R)-HYDROXYMYRISTOY
L-[ACYL-CARRIER-PROT
EIN] DEHYDRATASE

(Burkholderia
thailandensis) 		PF07977
(FabA) 		5 LEU A  81
LEU A  75
ALA A  74
LEU A 117
LEU A  35
 None
 1.27A 1s9pB-4h4gA:
undetectable		 1s9pB-4h4gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hva CASPASE-6

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 CYH A 113
ALA A 111
VAL A 106
LEU A  48
PHE A  83
 None
 1.27A 1s9pB-4hvaA:
undetectable		 1s9pB-4hvaA:
26.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4is8 NUCLEAR RECEPTOR
SUBFAMILY 5 GROUP A
MEMBER 2

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 CYH A 346
ALA A 349
LEU A 386
ARG A 393
LEU A 427
 None
 0.88A 1s9pB-4is8A:
23.3		 1s9pB-4is8A:
32.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf6 GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF08718
(GLTP) 		5 LEU A 210
LEU A  91
MET A  64
LEU A  67
LEU A  79
 None
 1.17A 1s9pB-4kf6A:
undetectable		 1s9pB-4kf6A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Mycobacterium
avium) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		5 LEU A  21
LEU A 113
ALA A 139
LEU A 110
LEU A  30
 None
 1.22A 1s9pB-4lgvA:
undetectable		 1s9pB-4lgvA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Mycobacterium
avium) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		5 LEU A 113
ALA A 139
LEU A 110
VAL A  13
LEU A  30
 None
 1.28A 1s9pB-4lgvA:
undetectable		 1s9pB-4lgvA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		7 LEU A 280
LEU A 286
ALA A 287
GLU A 290
MET A 321
LEU A 324
ARG A 331
 None
 0.52A 1s9pB-4n1yA:
28.8		 1s9pB-4n1yA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 LEU A 757
ALA A 708
VAL A 711
LEU A 721
PHE A 738
 None
 1.25A 1s9pB-4p72A:
undetectable		 1s9pB-4p72A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		5 LEU A 366
LEU A  42
ALA A 400
LEU A 327
LEU A 334
 None
 1.24A 1s9pB-4q76A:
undetectable		 1s9pB-4q76A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 766
LEU A 772
ALA A 773
MET A 807
LEU A 810
ARG A 817
 CV7  A1987 (-3.6A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.5A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.7A)
 0.66A 1s9pB-4udbA:
26.1		 1s9pB-4udbA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN

(Tetrahymena
thermophila) 		PF12317
(IFT46_B_C)
no annotation 		5 LEU A 296
CYH A 300
LEU A 302
ALA A 303
LEU B 592
 None
 0.88A 1s9pB-4uzzA:
undetectable		 1s9pB-4uzzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnx NETRIN-4

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		5 LEU A 130
LEU A  43
VAL A 289
ARG A  37
LEU A 119
 None
 1.15A 1s9pB-4wnxA:
undetectable		 1s9pB-4wnxA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9n L-ALPHA-GLYCEROPHOSP
HATE OXIDASE

(Mycoplasma
pneumoniae) 		PF01266
(DAO) 		5 LEU A 343
LEU A   7
VAL A  29
LEU A 365
PHE A 340
 None
 1.22A 1s9pB-4x9nA:
undetectable		 1s9pB-4x9nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 LEU A 177
ALA A 178
LEU A 208
VAL A 115
LEU A 224
 None
 1.31A 1s9pB-4xg0A:
undetectable		 1s9pB-4xg0A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo0 PROTEIN REP68

(Adeno-associated
dependoparvovirus
A) 		PF08724
(Rep_N) 		5 CYH A 179
ALA A 178
GLU A 184
LEU A 188
PHE A  79
 None
 1.28A 1s9pB-4zo0A:
undetectable		 1s9pB-4zo0A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoh CARF

(Serratia sp.
ATCC 39006) 		PF03781
(FGE-sulfatase) 		5 LEU A 242
ALA A 147
LEU A  34
ARG A 142
LEU A 202
 None
 1.20A 1s9pB-5aohA:
undetectable		 1s9pB-5aohA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyw INTERFERON
ANTAGONIST C7

(Vaccinia virus) 		PF03287
(Pox_C7_F8A) 		5 LEU B  61
LEU B  98
GLU B  96
LEU B  20
PHE B  44
 None
 1.29A 1s9pB-5cywB:
undetectable		 1s9pB-5cywB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dj4 SESTRIN-2

(Homo sapiens) 		PF04636
(PA26) 		5 LEU A 295
ALA A 429
LEU A 459
VAL A 455
LEU A 417
 None
None
None
LEU  A 501 ( 4.9A)
None
 1.29A 1s9pB-5dj4A:
undetectable		 1s9pB-5dj4A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h65 ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG
PROTECTION OF
TELOMERES PROTEIN 1

(Homo sapiens) 		no annotation 5 LEU A 445
LEU B 274
ALA B 275
LEU A 466
LEU A 452
 None
 1.23A 1s9pB-5h65A:
undetectable		 1s9pB-5h65A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A 208
LEU A 213
ALA A 214
GLU A 217
ARG A  95
 None
 1.21A 1s9pB-5iq0A:
undetectable		 1s9pB-5iq0A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 CYH A 953
LEU A 955
ALA A 956
VAL A 996
LEU A1011
 None
 1.15A 1s9pB-5irmA:
undetectable		 1s9pB-5irmA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 LEU A 432
ALA A 313
LEU A 335
LEU A 424
PHE A 339
 None
 1.20A 1s9pB-5l56A:
undetectable		 1s9pB-5l56A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 766
LEU A 772
ALA A 773
MET A 807
ARG A 817
 ECV  A1101 ( 3.9A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.8A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
 0.62A 1s9pB-5mwpA:
27.2		 1s9pB-5mwpA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 LEU A 451
GLU A 777
VAL A 735
TYR A 456
LEU A 607
 None
9FQ  A 911 (-3.6A)
None
None
None
 1.22A 1s9pB-5o0sA:
undetectable		 1s9pB-5o0sA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0g PROTEASOME SUBUNIT
BETA TYPE-5

(Homo sapiens) 		PF00227
(Proteasome) 		5 LEU R 155
ALA R 156
LEU R   4
TYR R 143
LEU R 111
 None
 1.22A 1s9pB-5t0gR:
undetectable		 1s9pB-5t0gR:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tic ACYL-COA
THIOESTERASE I

(Escherichia
coli) 		PF13472
(Lipase_GDSL_2) 		5 LEU A  70
LEU A 128
LEU A 136
VAL A 134
LEU A  67
 None
 1.16A 1s9pB-5ticA:
undetectable		 1s9pB-5ticA:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 301
ALA A 302
GLU A 305
MET A 336
LEU A 339
ARG A 346
 EST  A 601 ( 4.3A)
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
EST  A 601 (-4.1A)
 0.42A 1s9pB-5toaA:
28.4		 1s9pB-5toaA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 301
ALA A 302
MET A 336
LEU A 339
LEU A 380
 EST  A 601 ( 4.3A)
EST  A 601 ( 3.9A)
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
None
 1.24A 1s9pB-5toaA:
28.4		 1s9pB-5toaA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 LEU A 306
LEU A 312
ALA A 313
LEU A  23
VAL A   9
 None
 0.97A 1s9pB-5tulA:
undetectable		 1s9pB-5tulA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis) 		no annotation 5 ALA A  73
LEU A  71
VAL A  91
LEU A  64
PHE A 163
 None
 0.91A 1s9pB-5ufmA:
undetectable		 1s9pB-5ufmA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN

(Human
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		5 LEU A  94
LEU A 157
ALA A 107
GLU A 108
ARG A 543
 None
 1.19A 1s9pB-5vylA:
undetectable		 1s9pB-5vylA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq0 STAGE 0 SPORULATION
PROTEIN

(Paenisporosarcina
sp. TG-14) 		no annotation 5 LEU B  15
ALA B   9
LEU B  53
VAL B   6
LEU B 115
 None
 1.05A 1s9pB-5wq0B:
undetectable		 1s9pB-5wq0B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwm RRNA BIOGENESIS
PROTEIN RRP5

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A1502
ALA A1498
GLU A1499
VAL A1536
ARG A1539
 None
 1.30A 1s9pB-5wwmA:
undetectable		 1s9pB-5wwmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzd ENOYL-COA HYDRATASE

(Roseovarius
nubinhibens) 		no annotation 5 LEU A 107
CYH A 111
LEU A 113
ALA A 114
PHE A 128
 None
 1.30A 1s9pB-5xzdA:
undetectable		 1s9pB-5xzdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm9 UDP-N-ACETYLGLUCOSAM
INE--DOLICHYL-PHOSPH
ATE
N-ACETYLGLUCOSAMINEP
HOSPHOTRANSFERASE

(Homo sapiens) 		no annotation 5 LEU A  70
LEU A 103
ALA A 104
LEU A 136
VAL A 139
 None
 1.11A 1s9pB-6fm9A:
undetectable		 1s9pB-6fm9A:
undetectable